"Proteins Unique Sequence ID" "Checked" "Protein FDR Confidence: Combined" "Master" "Accession" "Description" "Exp. q-value: Combined" "Contaminant" "Sum PEP Score" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "Reactome Pathways" "WikiPathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundance Ratio: (127N, 50C) / (126, 50C)" "Abundance Ratio: (127C, 50C) / (126, 50C)" "Abundance Ratio: (128N, 50C) / (126, 50C)" "Abundance Ratio: (128C, 50C) / (126, 50C)" "Abundance Ratio: (129N, 50C) / (126, 50C)" "Abundance Ratio: (129C, 50C) / (126, 50C)" "Abundance Ratio: (130N, 50C) / (126, 50C)" "Abundance Ratio: (130C, 50C) / (126, 50C)" "Abundance Ratio: (131, 50C) / (126, 50C)" "Abundances (Grouped): 126, 50C" "Abundances (Grouped): 127N, 50C" "Abundances (Grouped): 127C, 50C" "Abundances (Grouped): 128N, 50C" "Abundances (Grouped): 128C, 50C" "Abundances (Grouped): 129N, 50C" "Abundances (Grouped): 129C, 50C" "Abundances (Grouped): 130N, 50C" "Abundances (Grouped): 130C, 50C" "Abundances (Grouped): 131, 50C" "Abundances (Grouped) CV [%]: 126, 50C" "Abundances (Grouped) CV [%]: 127N, 50C" "Abundances (Grouped) CV [%]: 127C, 50C" "Abundances (Grouped) CV [%]: 128N, 50C" "Abundances (Grouped) CV [%]: 128C, 50C" "Abundances (Grouped) CV [%]: 129N, 50C" "Abundances (Grouped) CV [%]: 129C, 50C" "Abundances (Grouped) CV [%]: 130N, 50C" "Abundances (Grouped) CV [%]: 130C, 50C" "Abundances (Grouped) CV [%]: 131, 50C" "Abundance: F12: 126, Sample, 50C" "Abundance: F12: 127N, Sample, 50C" "Abundance: F12: 127C, Sample, 50C" "Abundance: F12: 128N, Sample, 50C" "Abundance: F12: 128C, Sample, 50C" "Abundance: F12: 129N, Sample, 50C" "Abundance: F12: 129C, Sample, 50C" "Abundance: F12: 130N, Sample, 50C" "Abundance: F12: 130C, Sample, 50C" "Abundance: F12: 131, Sample, 50C" "Abundances Count: F12: 126, Sample, 50C" "Abundances Count: F12: 127N, Sample, 50C" "Abundances Count: F12: 127C, Sample, 50C" "Abundances Count: F12: 128N, Sample, 50C" "Abundances Count: F12: 128C, Sample, 50C" "Abundances Count: F12: 129N, Sample, 50C" "Abundances Count: F12: 129C, Sample, 50C" "Abundances Count: F12: 130N, Sample, 50C" "Abundances Count: F12: 130C, Sample, 50C" "Abundances Count: F12: 131, Sample, 50C" "Found in Sample: [S111] F12: 126, Sample, 50C" "Found in Sample: [S112] F12: 127N, Sample, 50C" "Found in Sample: [S113] F12: 127C, Sample, 50C" "Found in Sample: [S114] F12: 128N, Sample, 50C" "Found in Sample: [S115] F12: 128C, Sample, 50C" "Found in Sample: [S116] F12: 129N, Sample, 50C" "Found in Sample: [S117] F12: 129C, Sample, 50C" "Found in Sample: [S118] F12: 130N, Sample, 50C" "Found in Sample: [S119] F12: 130C, Sample, 50C" "Found in Sample: [S120] F12: 131, Sample, 50C" "# Protein Groups" "Modifications" "-880435081762619547" "False" "High" "IsMasterProtein" "Q09666" "Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens OX=9606 GN=AHNAK PE=1 SV=2" "0.000" "False" "813.592" "37" "121" "256" "121" "5890" "628.7" "6.15" "767.18" "121" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "79026" "ENSG00000124942" "AHNAK" "A1A586; hsa:79026; Q09666" "" "" "0" "0" "0.990" "0.986" "1.018" "1.009" "1.019" "0.986" "0.979" "0.961" "0.898" "15197.1" "15039.4" "14979.3" "15476.6" "15333.2" "15481.3" "14982.9" "14882.1" "14602.1" "13645.6" "" "" "" "" "" "" "" "" "" "" "13718.0" "11600.6" "11585.5" "10421.9" "12790.4" "13213.5" "12709.7" "10770.1" "9848.9" "13645.6" "100" "100" "100" "100" "100" "100" "100" "100" "100" "100" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2962281166201317424" "False" "High" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "0.000" "False" "748.426" "43" "82" "308" "69" "1960" "226.4" "5.60" "1071.96" "82" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome; HDAC6 interactions in the central nervous system" "17" "12" "1.071" "0.960" "0.960" "1.016" "0.821" "1.057" "1.058" "0.973" "0.919" "15977.9" "17106.7" "15336.5" "15343.6" "16237.3" "13119.9" "16889.1" "16897.0" "15539.7" "14685.6" "" "" "" "" "" "" "" "" "" "" "14422.8" "13195.1" "11861.8" "10332.4" "13544.5" "11198.0" "14326.7" "12228.2" "10481.3" "14685.6" "80" "80" "80" "80" "80" "80" "80" "80" "80" "80" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5927523368410573672" "False" "High" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "0.000" "False" "454.906" "22" "85" "153" "85" "4128" "468.8" "7.12" "483.54" "85" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "13" "0" "1.026" "0.709" "1.017" "1.035" "0.754" "1.002" "0.977" "0.755" "0.790" "7145.8" "7333.9" "5067.5" "7268.5" "7395.1" "5387.2" "7157.9" "6979.1" "5394.8" "5646.2" "" "" "" "" "" "" "" "" "" "" "6450.3" "5657.0" "3919.4" "4894.6" "6168.7" "4598.0" "6072.0" "5050.7" "3638.7" "5646.2" "62" "62" "62" "62" "62" "62" "62" "62" "62" "62" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305783293341844831" "False" "High" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "0.000" "False" "423.787" "19" "90" "142" "89" "4646" "532.1" "6.40" "441.89" "90" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Neutrophil degranulation; HCMV Early Events; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; PAFAH1B1 copy number variation" "24" "0" "0.999" "0.769" "0.978" "1.000" "0.762" "0.990" "0.976" "0.784" "0.951" "8420.5" "8414.7" "6477.3" "8238.2" "8422.7" "6416.8" "8334.6" "8219.5" "6602.1" "8008.3" "" "" "" "" "" "" "" "" "" "" "7601.0" "6490.6" "5009.8" "5547.6" "7025.9" "5476.8" "7070.1" "5948.4" "4453.0" "8008.3" "66" "66" "66" "66" "66" "66" "66" "66" "66" "66" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6252367434931231115" "False" "High" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "0.000" "False" "416.782" "27" "55" "156" "55" "2511" "273.3" "6.44" "508.92" "55" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf16197, Pf21089, Pf21149" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "18" "0" "0.973" "0.858" "0.968" "0.983" "0.836" "0.995" "0.982" "0.820" "0.959" "8118.2" "7899.7" "6962.2" "7854.7" "7982.9" "6788.7" "8075.7" "7969.4" "6655.8" "7785.2" "" "" "" "" "" "" "" "" "" "" "7328.1" "6093.4" "5384.8" "5289.3" "6659.0" "5794.3" "6850.4" "5767.4" "4489.3" "7785.2" "53" "53" "53" "53" "53" "53" "53" "53" "53" "53" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4615289327887409645" "False" "High" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "0.000" "False" "374.275" "28" "61" "103" "54" "2541" "269.6" "6.07" "347.25" "61" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511, Pf21692" "7094" "ENSG00000137076" "TLN1" "A0A1S5UZ07; A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Platelet degranulation ; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "18" "5" "0.960" "0.921" "1.016" "1.009" "0.922" "1.049" "0.980" "0.939" "1.577" "5516.3" "5294.8" "5080.3" "5606.9" "5563.5" "5088.6" "5785.5" "5407.2" "5180.3" "8698.2" "" "" "" "" "" "" "" "" "" "" "4979.4" "4084.1" "3929.3" "3775.7" "4640.9" "4343.2" "4907.8" "3913.1" "3494.1" "8698.2" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4567547795878987385" "False" "High" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "0.000" "False" "360.689" "26" "57" "88" "51" "2647" "280.6" "6.06" "322.68" "57" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome" "14" "6" "0.956" "0.839" "0.991" "0.925" "0.832" "0.924" "0.879" "0.845" "1.416" "4894.8" "4677.9" "4108.9" "4853.0" "4528.8" "4072.7" "4522.3" "4303.0" "4136.3" "6929.0" "" "" "" "" "" "" "" "" "" "" "4418.4" "3608.3" "3178.0" "3268.0" "3777.8" "3476.1" "3836.2" "3114.1" "2789.9" "6929.0" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2220837361715177214" "False" "High" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "0.000" "False" "360.321" "47" "32" "306" "18" "724" "83.2" "5.03" "975.49" "32" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "Potential therapeutics for SARS; Regulation of actin dynamics for phagocytic cup formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Neutrophil degranulation; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "25" "15" "0.951" "0.733" "0.964" "0.965" "0.756" "0.994" "0.967" "0.731" "0.897" "18250.1" "17354.9" "13379.1" "17587.9" "17612.6" "13805.7" "18133.5" "17651.2" "13338.5" "16367.5" "" "" "" "" "" "" "" "" "" "" "16473.9" "13386.6" "10347.9" "11843.7" "14691.8" "11783.3" "15382.3" "12774.1" "8996.7" "16367.5" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6488855965708197639" "False" "High" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "0.000" "False" "356.935" "54" "26" "362" "25" "531" "57.9" "7.84" "1150.91" "26" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Neutrophil degranulation" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "10" "1" "0.999" "1.066" "1.000" "0.997" "1.123" "0.992" "1.003" "1.080" "0.703" "13258.1" "13243.3" "14138.3" "13264.3" "13218.3" "14891.9" "13154.7" "13293.7" "14324.9" "9317.8" "" "" "" "" "" "" "" "" "" "" "11967.7" "10215.1" "10935.1" "8932.2" "11026.2" "12710.4" "11158.9" "9620.6" "9662.0" "9317.8" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5005343800474254733" "False" "High" "IsMasterProtein" "P13796" "Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6" "0.000" "False" "356.740" "50" "26" "350" "21" "627" "70.2" "5.43" "1065.19" "26" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00036, Pf00307" "3936" "ENSG00000136167" "LCP1" "B2R613; B4DUA0; hsa:3936; P13796; Q5TBN4" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "6" "1.005" "1.082" "1.076" "1.034" "1.113" "1.016" "1.021" "1.138" "0.712" "15806.6" "15892.3" "17106.7" "17009.3" "16340.6" "17587.5" "16062.6" "16133.2" "17995.6" "11261.3" "" "" "" "" "" "" "" "" "" "" "14268.2" "12258.4" "13230.9" "11454.0" "13630.7" "15011.2" "13625.6" "11675.5" "12137.8" "11261.3" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705476780399299386" "False" "High" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "0.000" "False" "335.204" "31" "42" "94" "41" "1657" "189.1" "6.48" "315.06" "42" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "25" "1" "0.981" "0.766" "0.939" "0.949" "0.752" "0.939" "0.923" "0.749" "1.062" "5259.9" "5162.4" "4027.8" "4939.2" "4993.0" "3957.9" "4937.3" "4854.1" "3937.4" "5586.5" "" "" "" "" "" "" "" "" "" "" "4747.9" "3982.0" "3115.3" "3326.1" "4165.0" "3378.1" "4188.2" "3512.9" "2655.7" "5586.5" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-613397371873318473" "False" "High" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "0.000" "False" "331.968" "45" "32" "127" "32" "840" "94.3" "5.19" "426.59" "32" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Regulation of HSF1-mediated heat shock response" "Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "3" "0" "1.011" "1.138" "1.008" "0.995" "1.113" "1.018" "1.006" "1.131" "0.824" "8245.7" "8335.7" "9381.8" "8310.4" "8208.4" "9178.0" "8392.3" "8291.1" "9323.1" "6796.8" "" "" "" "" "" "" "" "" "" "" "7443.2" "6429.7" "7256.2" "5596.2" "6847.2" "7833.5" "7119.0" "6000.2" "6288.3" "6796.8" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-66753491464337277" "False" "High" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "0.000" "False" "329.832" "27" "65" "88" "65" "2472" "284.4" "5.35" "296.16" "65" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "Neutrophil degranulation; RHOV GTPase cycle; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Caspase-mediated cleavage of cytoskeletal proteins" "Fas ligand pathway and stress induction of heat shock proteins" "12" "0" "1.014" "1.102" "0.984" "0.976" "1.107" "1.002" "1.009" "1.099" "0.801" "5417.4" "5493.0" "5968.5" "5328.7" "5285.4" "5996.4" "5429.4" "5466.1" "5955.7" "4339.1" "" "" "" "" "" "" "" "" "" "" "4890.2" "4237.0" "4616.3" "3588.3" "4408.9" "5118.0" "4605.7" "3955.7" "4017.1" "4339.1" "51" "51" "51" "51" "51" "51" "51" "51" "51" "51" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7065009906831580898" "False" "High" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "0.000" "False" "297.540" "42" "30" "239" "16" "732" "84.6" "5.02" "744.44" "30" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced AP-1 survival signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway; HDAC6 interactions in the central nervous system" "71" "1" "0.973" "0.741" "0.904" "0.938" "0.739" "0.944" "0.960" "0.738" "0.854" "5848.8" "5688.3" "4334.8" "5288.2" "5484.4" "4321.7" "5521.1" "5615.2" "4318.1" "4996.2" "" "" "" "" "" "" "" "" "" "" "5279.5" "4387.6" "3352.7" "3561.1" "4574.9" "3688.6" "4683.4" "4063.7" "2912.5" "4996.2" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5864065326781896084" "False" "High" "IsMasterProtein" "P27708" "Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "0.000" "False" "291.585" "24" "44" "88" "43" "2225" "242.8" "6.46" "284.66" "44" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Pyrimidine biosynthesis" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "4" "1" "1.059" "0.798" "1.012" "1.107" "0.824" "1.059" "1.052" "0.846" "0.977" "3587.5" "3800.9" "2864.6" "3630.2" "3972.0" "2956.1" "3799.9" "3774.0" "3035.8" "3503.5" "" "" "" "" "" "" "" "" "" "" "3238.4" "2931.8" "2215.6" "2444.6" "3313.3" "2523.1" "3223.4" "2731.2" "2047.6" "3503.5" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6896953880380314494" "False" "High" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "0.000" "False" "290.914" "43" "31" "130" "31" "806" "89.3" "5.26" "415.66" "31" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5; V9HW80" "ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; E3 ubiquitin ligases ubiquitinate target proteins; Aggrephagy; Neutrophil degranulation; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; RHOH GTPase cycle; HSF1 activation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism; HDAC6 interactions in the central nervous system" "21" "0" "0.980" "1.045" "1.027" "0.979" "1.080" "0.994" "1.007" "1.083" "0.719" "5890.6" "5775.0" "6154.3" "6047.2" "5764.0" "6363.1" "5852.6" "5930.3" "6380.3" "4237.1" "" "" "" "" "" "" "" "" "" "" "5317.3" "4454.5" "4759.9" "4072.2" "4808.1" "5431.0" "4964.6" "4291.7" "4303.4" "4237.1" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4769002131436570839" "False" "High" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "0.000" "False" "290.760" "28" "39" "96" "39" "1675" "191.5" "5.69" "317.61" "39" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "25" "0" "0.955" "1.098" "0.964" "0.988" "1.126" "0.986" "0.978" "1.109" "0.842" "4017.5" "3836.9" "4411.4" "3871.7" "3967.6" "4522.2" "3962.3" "3928.4" "4457.4" "3381.2" "" "" "" "" "" "" "" "" "" "" "3626.5" "2959.6" "3411.9" "2607.2" "3309.6" "3859.8" "3361.1" "2843.0" "3006.4" "3381.2" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5619484675981056092" "False" "High" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "0.000" "False" "276.670" "59" "26" "188" "26" "573" "61.0" "5.87" "593.32" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Mitochondrial protein degradation; Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "6" "0" "0.986" "1.038" "0.977" "0.964" "1.028" "0.992" "0.975" "1.031" "0.605" "10497.1" "10350.2" "10898.4" "10252.3" "10118.1" "10794.1" "10411.8" "10232.6" "10824.9" "6353.0" "" "" "" "" "" "" "" "" "" "" "9475.4" "7983.6" "8429.2" "6903.9" "8440.2" "9212.9" "8832.2" "7405.3" "7301.3" "6353.0" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015185769260426388" "False" "High" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "0.000" "False" "274.781" "38" "40" "127" "40" "1101" "120.8" "7.33" "399.68" "40" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "10" "0" "0.972" "0.781" "0.959" "0.970" "0.785" "0.972" "1.003" "0.789" "0.723" "8790.5" "8540.7" "6867.7" "8427.0" "8526.6" "6896.8" "8542.1" "8817.6" "6939.1" "6356.6" "" "" "" "" "" "" "" "" "" "" "7934.9" "6587.8" "5311.7" "5674.7" "7112.5" "5886.6" "7246.1" "6381.2" "4680.3" "6356.6" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-174490317750568225" "False" "High" "IsMasterProtein" "Cont_P60712" "Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1" "0.000" "True" "266.749" "51" "16" "305" "5" "375" "41.7" "5.48" "1019.88" "16" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100011313; 100011351; 100033878; 100078865; 100135470; 100173832; 100303677; 100654618; 100689477; 100919051; 101026869; 101098507; 101375328; 101813373; 101844587; 101941176; 101958638; 102030392; 102041442; 102067189; 102179831; 102286048; 102386754; 102744309; 102772396; 102884469; 103050159; 103077223; 103115297; 103197222; 105077471; 105294565; 105497365; 105551087; 105719490; 105868294; 105990935; 106497948; 107155983; 107515934; 108496585; 108538237; 109314696; 109380220; 109700700; 11461; 280979; 396526; 403580; 414396; 443052; 450133; 574285; 60; 81822" "ENSABRG00000002004; ENSACOG00000001373; ENSACUG00000014525; ENSAMEG00000019137; ENSAMEG00000025519; ENSAMEG00000030859; ENSANAG00000024575; ENSAPLG00020013590; ENSBIXG00000014387; ENSBIXG00005017151; ENSBJAG00000012824; ENSBOBG00000008860; ENSBTAG00000026199; ENSCABG00000005869; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCAFG00805000771; ENSCCEG00000022540; ENSCCNG00000030119; ENSCGRG00001015781; ENSCHIG00000013316; ENSCJAG00000074750; ENSCJAG00000083114; ENSCLAG00000013196; ENSCMUG00000004054; ENSCPBG00000020809; ENSCPGG00000001752; ENSCPOG00000013467; ENSCPRG00005016203; ENSCPVG00000014059; ENSCSRG00000014125; ENSCUSG00005013766; ENSDLEG00000020930; ENSFALG00000013828; ENSFCAG00000006788; ENSFTIG00000005623; ENSG00000075624; ENSGAGG00000004381; ENSGEVG00005007981; ENSGGOG00000001133; ENSJHYG00000006128; ENSJJAG00000018929; ENSLCNG00005020599; ENSMCSG00000014736; ENSMICG00000002791; ENSMLEG00000038914; ENSMMMG00000007553; ENSMMNG00015004465; ENSMMSG00000018023; ENSMMUG00000011153; ENSMNEG00000033949; ENSMODG00000002647; ENSMPUG00000016612; ENSMUGG00000013478; ENSMUNG00000007311; ENSMUSG00000029580; ENSNVIG00000005620; ENSOANG00000007716; ENSOARG00020008714; ENSOSUG00000006211; ENSPANG00000015700; ENSPCEG00000013440; ENSPCLG00000014414; ENSPCTG00005017252; ENSPEMG00000012952; ENSPLOG00000015512; ENSPPYG00000017336; ENSPSTG00000003558; ENSPTEG00000021167; ENSPTRG00000018890; ENSPTXG00000006649; ENSRBIG00000014104; ENSRFEG00010011816; ENSRNOG00000034254; ENSRNOG00055011660; ENSRNOG00060020294; ENSRNOG00065000139; ENSSBOG00000033859; ENSSHAG00000029431; ENSSHBG00005009495; ENSSOCG00000011957; ENSSSCG00000007585; ENSSSCG00005020690; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSUG00005004355; ENSSTOG00000014797; ENSSVLG00005024720; ENSTGEG00000001941; ENSTMTG00000013939; ENSVKKG00000006783; ENSVURG00010018277; ENSZALG00000007655; ENSZLMG00000002642" "Actb; ACTB; Actb_0; ACTL8; LOC101872991; LOC106497948; LOC111145734; LOC112063645; LOC117800408; LOC118142876; PS1TP5BP1" "A0A096NAA6; A0A098M1X5; A0A0B6VJU7; A0A0B8RRU9; A0A0B8RTY2; A0A1D9CFN7; A0A1S2ZVA4; A0A1S3FRD3; A0A1U7Q273; A0A1W7RJQ3; A0A218UWT5; A0A226NJ42; A0A250YGN4; A0A2D4GG12; A0A2J8KJN5; A0A2J8RAH6; A0A2K5CXD5; A0A2K5ZNV7; A0A2K6C9L8; A0A2K6JVX9; A0A2K6UUH3; A0A2P4SFV3; A0A2U3VHD6; A0A2U3XSJ3; A0A2Y9GE45; A0A2Y9JFQ8; A0A2Y9MFS3; A0A2Y9S868; A0A340WEU6; A0A341CY14; A0A384AHN3; A0A3Q7NCZ0; A0A452EGB1; A0A452GTY2; A0A4D9ENE9; A0A4W2DYQ2; A0A4X2LSI7; A0A5E4C6E9; A0A5J5MXV1; A0A5N3VUL9; A0A5N4CXK3; A0A663NBJ0; A0A667IZV1; A0A669QC85; A0A670YBF6; A0A671EW41; A0A672U7D6; A0A673TCM5; A0A674JEF6; A0A6B0SBF2; A0A6B2F1I3; A0A6B2FBI6; A0A6I9HGD1; A0A6J0H3K7; A0A6J0VYA4; A0A6J1Y0U5; A0A6J2ER79; A0A6J2G0V3; A0A6J2MYQ0; A0A6J3AFQ7; A0A6J3DTG2; A0A6J3GBY8; A0A6J3PXY9; A0A6P3QDF4; A0A6P5M7F0; A0A6P5PSI5; A0A6P9D9Q3; A0A7J7X8Z4; A0A7J8FJ79; A0A7J8I7K0; A0A7K4LHI1; A0A7K4PGF5; A0A7K4QS53; A0A7K4T128; A0A7K4TT29; A0A7K4VIP3; A0A7K4WM66; A0A7K4XNG5; A0A7K4Z9S9; A0A7K5AA34; A0A7K5AS89; A0A7K5BQ55; A0A7K5FSS5; A0A7K5H4P8; A0A7K5I2U8; A0A7K5K1W1; A0A7K5L347; A0A7K5MV66; A0A7K5NYG3; A0A7K5PUR4; A0A7K5QKD4; A0A7K5SEW2; A0A7K5SN56; A0A7K5UCA8; A0A7K5V0T3; A0A7K5W0A4; A0A7K5XZZ2; A0A7K5YRX7; A0A7K5ZQ33; A0A7K6AXY2; A0A7K6BYL2; A0A7K6FAZ8; A0A7K6H213; A0A7K6K8T2; A0A7K6M1I6; A0A7K6NUL4; A0A7K6QDF5; A0A7K6RH22; A0A7K6TM80; A0A7K6VD36; A0A7K6W7N1; A0A7K6X5J8; A0A7K6YU38; A0A7K7C2G9; A0A7K7EJS7; A0A7K7FS46; A0A7K7GD18; A0A7K7IBW8; A0A7K7K4W1; A0A7K7KKG3; A0A7K7MQH8; A0A7K7MV68; A0A7K7PD37; A0A7K7QM76; A0A7K7SE36; A0A7K7SKG2; A0A7K7VCN0; A0A7K7W887; A0A7K7XYY4; A0A7K7YKB8; A0A7K8CFW2; A0A7K8EJC7; A0A7K8FS78; A0A7K8G222; A0A7K8IUQ2; A0A7K8JZV4; A0A7K8LPI3; A0A7K8NBM6; A0A7K8PNA5; A0A7K8Q6L8; A0A7K8RIG2; A0A7K8SZY6; A0A7K8UAQ8; A0A7K8VV48; A0A7K8WC57; A0A7K8XP00; A0A7K8YCU6; A0A7K9A6Q1; A0A7K9CAW4; A0A7K9CTY4; A0A7K9E1U2; A0A7K9FBL7; A0A7K9GU20; A0A7K9HIF7; A0A7K9J0P9; A0A7K9JQ87; A0A7K9LVG6; A0A7K9R4T1; A0A7K9RUC2; A0A7K9T1K6; A0A7K9TJU9; A0A7K9VM54; A0A7K9W8F9; A0A7K9XJP5; A0A7K9YTX8; A0A7L0B981; A0A7L0CFC2; A0A7L0DK08; A0A7L0EE55; A0A7L0FB96; A0A7L0GQU8; A0A7L0IUJ7; A0A7L0K254; A0A7L0L680; A0A7L0MVK5; A0A7L0NBG6; A0A7L0Q6H1; A0A7L0RLK8; A0A7L0TBQ4; A0A7L0UF87; A0A7L0WJD4; A0A7L0ZXX6; A0A7L1D3E3; A0A7L1EEL1; A0A7L1EWI9; A0A7L1GDD0; A0A7L1I1H5; A0A7L1IUB6; A0A7L1K0S4; A0A7L1L6I1; A0A7L1MJS1; A0A7L1N7E9; A0A7L1QY43; A0A7L1R9N1; A0A7L1TFJ1; A0A7L1USL1; A0A7L1X2N1; A0A7L1YHH8; A0A7L1ZA36; A0A7L2AFK2; A0A7L2CBA6; A0A7L2DI04; A0A7L2E5K5; A0A7L2ETQ7; A0A7L2GZ90; A0A7L2HLP4; A0A7L2JI84; A0A7L2K9F9; A0A7L2LSR8; A0A7L2MKA1; A0A7L2NWG1; A0A7L2Q5Z6; A0A7L2TKF5; A0A7L2UQP2; A0A7L2WPM1; A0A7L3AB48; A0A7L3AEQ2; A0A7L3CBV1; A0A7L3GBT6; A0A7L3H4H6; A0A7L3I6Y5; A0A7L3KV16; A0A7L3L3C1; A0A7L3M5B9; A0A7L3NFE1; A0A7L3PPT4; A0A7L3QID2; A0A7L3RPI2; A0A7L3ST79; A0A7L3U378; A0A7L3VAR1; A0A7L3W396; A0A7L3X8C9; A0A7L3Z0M0; A0A7L4AJ46; A0A7L4BIP7; A0A7L4CC84; A0A7L4DQB0; A0A7L4EP40; A0A7L4HN55; A0A7L4J9W9; A0A7M4FIE6; A0A7N4PW14; A0A7T6ZK12; A0A811Z8F1; A0A850TFQ9; A0A850V5R2; A0A850W4N7; A0A850XKN3; A0A850YK23; A0A851A5U4; A0A851B4R4; A0A851CTC7; A0A851D320; A0A851E8C6; A0A851F1A8; A0A851JVZ7; A0A851K2P6; A0A851LU60; A0A851P5P0; A0A851R2P6; A0A851S6S6; A0A851T4V4; A0A851U0I3; A0A851VRP0; A0A851WCV5; A0A851Y321; A0A851Z9B4; A0A852A4Z3; A0A852AR86; A0A852BQ86; A0A852DLV7; A0A852E4W4; A0A852G2S2; A0A852L7H9; A0A852LWU6; A0A852MIU4; A0A852P924; A0A8B6ZZ93; A0A8B7FY80; A0A8B7JWS2; A0A8B7QXR8; A0A8B8VBY0; A0A8B9BC47; A0A8B9EY57; A0A8B9TCS0; A0A8C0BMH3; A0A8C0GIN8; A0A8C0IEG6; A0A8C0VMY6; A0A8C2VXZ2; A0A8C3I6V8; A0A8C3J5G4; A0A8C3QCS8; A0A8C3SWN5; A0A8C3V1H9; A0A8C4U9L8; A0A8C4W3F9; A0A8C5IQ83; A0A8C5L3Y8; A0A8C5UI70; A0A8C5Z473; A0A8C6AVT7; A0A8C6E309; A0A8C6J2B6; A0A8C7ELL8; A0A8C8AQ23; A0A8C8SAX1; A0A8C8TJI2; A0A8C9D802; A0A8C9EU06; A0A8C9HDT2; A0A8D0FEG6; A0A8D2DXS1; A0A8D2E312; A0A8D2J5F6; A0A8D2QDJ6; A0A8D2QMT1; A0A8I3W1I0; A0A8J4I2Z8; A0A8J4N6K5; A0A8J4NKS0; A0A8J4P196; A0A8J4U9Z8; A0A8K0BW04; A0A8K1GFZ5; A0A8M1G7Q7; A0A8S9EM85; A0A8V5H9G0; A0A973YLC1; A0A9F2R4N2; A0A9W2UUK2; A0A9W3F4H2; A0AA35L9Q0; A0AA40H6S4; A0AA40LS06; A5D961; A5PKA1; A6K1N6; aam:106497948; aful:116495117; aju:106984514; asn:102386754; B2RRX1; bacu:103015338; bom:102286048; bta:280979; ccan:109700700; cfa:403580; cfr:102514032; cpic:101941176; cpoc:100135470; cpoo:109314696; D5MU85; D7RIF5; dle:111170344; dord:105990935; ecb:100033878; elk:111145734; F6TIK4; F6UDX9; F7DIB7; fab:101813373; fca:101098507; G1MLH3; G3GVD0; G3QFP0; G8HY07; gfr:102041442; gga:396526; hai:109380220; hsa:60; I3MNL1; J3S3X5; J7H0T4; L5L2F8; L5LSF7; lav:100654618; lve:103077223; lww:102744309; M3WRZ7; M3YYU9; M7B7E7; maua:101844587; mcal:110295381; mcc:574285; mdo:100011313; mdo:100011351; mleu:105551087; mmu:11461; mmur:105868294; mni:105497365; mpuf:101686268; myd:102772396; nasi:112412020; nsu:110572001; O18840; oaa:100078865; oro:101375328; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pale:102884469; panu:101026869; pbi:103050159; pcad:112063645; pcw:110223114; pdic:114509151; pgut:117676791; pon:100173832; ptr:450133; pvp:105294565; Q11209; Q11211; Q1KLZ0; Q25PW9; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q58J72; Q5R1X3; Q5R582; Q5R6G0; Q5W9H6; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; R0LHA7; ray:107515934; rbb:108538237; rno:81822; S9YTS3; sbq:101037287; shr:100919051; ssc:414396; T1DP26; U3FXK3; U3KHC4; umr:103670086; V9P8F4; vpc:102534524; zab:102067189; zca:113932833" "EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; RHO GTPases activate IQGAPs; Cell-extracellular matrix interactions; MAP2K and MAPK activation; UCH proteinases; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; UCH proteinases; RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHOF GTPase cycle; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Adherens junctions interactions; DNA Damage Recognition in GG-NER; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; RHO GTPases Activate Formins; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Adherens junctions interactions; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; MAP2K and MAPK activation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; RHO GTPases activate IQGAPs; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; UCH proteinases; Adherens junctions interactions; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of annular gap junctions" "FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion" "157" "13" "1.012" "1.036" "0.925" "1.024" "1.031" "1.001" "1.038" "1.022" "0.769" "14162.0" "14333.9" "14673.6" "13097.7" "14496.5" "14604.2" "14169.1" "14701.3" "14471.7" "10884.7" "" "" "" "" "" "" "" "" "" "" "12783.6" "11056.4" "11349.1" "8820.0" "12092.4" "12464.9" "12019.4" "10639.2" "9761.0" "10884.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453697574232543386" "False" "High" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "0.000" "False" "260.977" "41" "33" "103" "23" "911" "104.8" "5.44" "325.76" "33" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Platelet degranulation ; Nephrin family interactions" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "9" "8" "1.003" "1.122" "1.031" "1.004" "1.149" "1.018" "1.023" "1.148" "0.767" "4675.5" "4689.0" "5245.2" "4818.7" "4693.7" "5373.0" "4760.3" "4783.7" "5366.1" "3585.0" "" "" "" "" "" "" "" "" "" "" "4220.5" "3616.8" "4056.8" "3244.9" "3915.3" "4586.0" "4038.1" "3461.9" "3619.4" "3585.0" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-772083225745130744" "False" "High" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "0.000" "False" "259.208" "49" "28" "152" "19" "646" "70.9" "5.52" "495.66" "28" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; mRNA Splicing - Major Pathway; Golgi Associated Vesicle Biogenesis; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; Clathrin-mediated endocytosis; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase; Respiratory syncytial virus genome transcription" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system" "27" "9" "0.968" "1.031" "0.997" "0.947" "1.070" "0.943" "0.939" "1.021" "1.054" "9450.8" "9147.6" "9746.4" "9424.7" "8948.5" "10115.7" "8910.1" "8873.9" "9644.6" "9963.2" "" "" "" "" "" "" "" "" "" "" "8531.0" "7056.0" "7538.2" "6346.6" "7464.5" "8633.9" "7558.3" "6422.0" "6505.2" "9963.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293079878251606526" "False" "High" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "0.000" "False" "259.005" "38" "27" "152" "26" "803" "92.4" "4.84" "516.25" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "1.011" "0.882" "0.986" "1.056" "0.913" "1.061" "1.039" "0.902" "0.729" "8975.8" "9072.2" "7917.8" "8849.8" "9482.3" "8193.7" "9527.2" "9326.1" "8097.6" "6540.1" "" "" "" "" "" "" "" "" "" "" "8102.2" "6997.8" "6123.9" "5959.5" "7909.8" "6993.4" "8081.8" "6749.2" "5461.7" "6540.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6514754949609892250" "False" "High" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "0.000" "False" "252.621" "36" "43" "67" "43" "1217" "141.5" "7.18" "236.89" "43" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "Meiotic synapsis; Estrogen-dependent gene expression; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "15" "0" "1.008" "0.831" "0.956" "1.009" "0.801" "0.983" "0.995" "0.828" "0.733" "4952.9" "4992.5" "4117.9" "4734.4" "4998.5" "3967.6" "4869.7" "4925.8" "4098.9" "3630.6" "" "" "" "" "" "" "" "" "" "" "4470.9" "3850.9" "3184.9" "3188.1" "4169.6" "3386.4" "4130.9" "3564.8" "2764.6" "3630.6" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1034815253104013464" "False" "High" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "0.000" "False" "248.562" "56" "27" "123" "27" "548" "59.6" "5.60" "398.75" "27" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261; ENSG00000291533" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "Association of TriC/CCT with target proteins during biosynthesis; Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "8" "0" "1.019" "0.965" "0.974" "1.001" "0.974" "0.984" "0.966" "0.977" "0.719" "8183.3" "8341.4" "7898.9" "7967.4" "8191.5" "7972.8" "8051.1" "7906.8" "7997.1" "5883.0" "" "" "" "" "" "" "" "" "" "" "7386.8" "6434.1" "6109.3" "5365.2" "6833.0" "6804.9" "6829.6" "5722.1" "5394.0" "5883.0" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1119286615561917853" "False" "High" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "0.000" "False" "244.659" "60" "23" "132" "18" "417" "44.6" "8.10" "429.87" "23" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "13" "6" "0.977" "1.014" "0.983" "0.905" "1.034" "0.940" "0.967" "0.918" "0.672" "6599.3" "6445.4" "6692.0" "6485.7" "5974.1" "6823.0" "6205.9" "6382.5" "6056.0" "4437.2" "" "" "" "" "" "" "" "" "" "" "5957.0" "4971.6" "5175.8" "4367.5" "4983.4" "5823.5" "5264.3" "4619.0" "4084.7" "4437.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5561612098835552022" "False" "High" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "0.000" "False" "234.003" "41" "27" "96" "26" "679" "73.6" "6.16" "334.06" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein degradation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "7" "0" "1.020" "0.980" "0.983" "1.008" "0.999" "0.989" "0.991" "0.956" "0.826" "7211.9" "7354.9" "7065.9" "7092.4" "7271.3" "7203.8" "7132.7" "7150.2" "6893.9" "5955.5" "" "" "" "" "" "" "" "" "" "" "6510.0" "5673.2" "5465.0" "4776.0" "6065.4" "6148.6" "6050.6" "5174.5" "4649.9" "5955.5" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3002712347046388220" "False" "High" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "0.000" "False" "233.138" "51" "22" "84" "22" "535" "57.5" "6.46" "285.12" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "10" "0" "0.971" "0.990" "0.964" "0.967" "0.979" "0.977" "0.992" "0.918" "0.726" "5076.1" "4929.6" "5024.5" "4892.9" "4910.4" "4968.6" "4960.1" "5034.2" "4660.7" "3686.3" "" "" "" "" "" "" "" "" "" "" "4582.1" "3802.5" "3886.1" "3294.8" "4096.1" "4240.8" "4207.5" "3643.2" "3143.6" "3686.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576515921520274560" "False" "High" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "0.000" "False" "230.304" "55" "30" "93" "30" "645" "72.9" "5.07" "266.10" "30" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "0" "1.018" "0.982" "0.951" "1.038" "1.030" "1.007" "0.989" "0.992" "1.160" "4728.2" "4813.3" "4641.5" "4497.1" "4906.6" "4869.8" "4759.1" "4676.9" "4690.2" "5482.5" "" "" "" "" "" "" "" "" "" "" "4268.0" "3712.7" "3589.9" "3028.3" "4092.9" "4156.5" "4037.1" "3384.7" "3163.5" "5482.5" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851021478040607723" "False" "High" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "0.000" "False" "224.873" "51" "22" "85" "22" "592" "64.6" "6.71" "261.73" "22" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "One-carbon metabolism" "3" "0" "1.005" "0.800" "0.986" "1.031" "0.891" "1.013" "1.025" "0.828" "0.760" "4106.0" "4126.3" "3284.6" "4049.8" "4232.8" "3660.4" "4160.1" "4209.3" "3400.4" "3121.9" "" "" "" "" "" "" "" "" "" "" "3706.4" "3182.8" "2540.4" "2727.1" "3530.9" "3124.2" "3528.9" "3046.2" "2293.5" "3121.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3490068427957957642" "False" "High" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "0.000" "False" "219.603" "33" "27" "85" "27" "968" "106.7" "5.53" "256.68" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "Cytosolic tRNA aminoacylation" "IL-18 signaling pathway" "2" "0" "1.009" "0.750" "0.982" "1.018" "0.765" "0.987" "0.994" "0.767" "0.882" "4912.9" "4954.8" "3685.8" "4826.3" "4999.0" "3756.7" "4851.4" "4885.0" "3768.9" "4332.8" "" "" "" "" "" "" "" "" "" "" "4434.8" "3821.8" "2850.7" "3250.1" "4170.0" "3206.4" "4115.4" "3535.2" "2542.1" "4332.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5449770128653317074" "False" "High" "IsMasterProtein" "Cont_P15636" "Protease 1 OS=Achromobacter lyticus OX=224 PE=1 SV=1" "0.000" "True" "218.311" "19" "11" "261" "11" "653" "68.1" "7.24" "1031.97" "11" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf01483, Pf18911" "" "" "" "" "" "" "0" "0" "1.182" "1.754" "1.195" "1.461" "1.387" "1.358" "1.317" "1.484" "0.935" "9266.0" "10952.1" "16256.6" "11075.0" "13541.2" "12854.6" "12579.7" "12202.5" "13747.3" "8666.5" "" "" "" "" "" "" "" "" "" "" "8364.2" "8447.8" "12573.5" "7457.9" "11295.6" "10971.5" "10671.2" "8830.9" "9272.4" "8666.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "682895518506643546" "False" "High" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "0.000" "False" "212.186" "41" "23" "89" "20" "654" "72.3" "5.16" "294.98" "23" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "14" "0" "1.000" "1.020" "1.036" "1.011" "1.043" "0.972" "0.960" "1.010" "0.916" "4852.4" "4851.8" "4948.4" "5027.6" "4905.2" "5061.4" "4716.3" "4656.9" "4900.3" "4443.1" "" "" "" "" "" "" "" "" "" "" "4380.1" "3742.4" "3827.2" "3385.6" "4091.8" "4320.0" "4000.7" "3370.1" "3305.2" "4443.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927890985374291245" "False" "High" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4" "0.000" "False" "210.390" "37" "32" "73" "31" "935" "101.5" "7.30" "235.98" "32" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "4522" "ENSG00000100714" "MTHFD1" "A0A024R652; A0A384N5Y3; B2R5Y2; G3V2B8; hsa:4522; P11586; Q86VC9; Q9BVP5" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Male infertility; Spina bifida" "6" "0" "0.964" "0.691" "0.790" "0.810" "0.658" "0.846" "0.936" "0.584" "0.731" "5075.1" "4893.2" "3507.2" "4009.6" "4109.6" "3340.2" "4292.3" "4750.0" "2965.6" "3711.3" "" "" "" "" "" "" "" "" "" "" "4581.1" "3774.3" "2712.6" "2700.0" "3428.0" "2850.9" "3641.0" "3437.6" "2000.2" "3711.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7449371538365957033" "False" "High" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "0.000" "False" "210.049" "17" "40" "49" "40" "2363" "267.1" "5.02" "172.32" "40" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "" "29" "0" "0.974" "1.152" "1.051" "0.973" "1.155" "0.990" "0.888" "1.163" "2.304" "2642.0" "2573.8" "3043.2" "2777.9" "2571.6" "3051.0" "2616.5" "2345.1" "3072.8" "6087.8" "" "" "" "" "" "" "" "" "" "" "2384.9" "1985.3" "2353.7" "1870.6" "2145.2" "2604.0" "2219.5" "1697.1" "2072.6" "6087.8" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357852675593899782" "False" "High" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "0.000" "False" "206.301" "38" "29" "61" "29" "808" "90.9" "5.77" "200.39" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "11" "0" "1.032" "0.945" "0.948" "1.000" "0.947" "0.991" "1.041" "0.900" "1.080" "3578.9" "3693.3" "3380.9" "3392.0" "3577.7" "3389.5" "3546.6" "3725.5" "3220.2" "3866.1" "" "" "" "" "" "" "" "" "" "" "3230.6" "2848.8" "2614.9" "2284.1" "2984.4" "2893.0" "3008.5" "2696.1" "2172.0" "3866.1" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7834140751544997544" "False" "High" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "0.000" "False" "203.513" "9" "36" "48" "36" "4374" "481.6" "5.22" "164.91" "36" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "" "2" "0" "1.003" "0.776" "0.971" "0.983" "0.774" "0.977" "0.970" "0.785" "0.956" "2151.5" "2157.1" "1669.1" "2089.0" "2115.1" "1664.4" "2101.7" "2086.1" "1689.8" "2056.3" "" "" "" "" "" "" "" "" "" "" "1942.1" "1663.8" "1290.9" "1406.7" "1764.4" "1420.6" "1782.8" "1509.7" "1139.7" "2056.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7224600777690592247" "False" "High" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "0.000" "False" "201.647" "55" "26" "80" "25" "539" "57.9" "7.83" "255.04" "26" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "1" "0.980" "0.939" "0.997" "1.018" "0.984" "1.004" "0.992" "0.977" "0.749" "4045.6" "3966.4" "3797.1" "4032.3" "4116.6" "3980.9" "4063.4" "4013.8" "3953.5" "3028.3" "" "" "" "" "" "" "" "" "" "" "3651.9" "3059.5" "2936.8" "2715.3" "3433.9" "3397.7" "3446.9" "2904.8" "2666.6" "3028.3" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6942352143814958774" "False" "High" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "0.000" "False" "198.649" "43" "23" "93" "23" "545" "60.5" "6.49" "280.00" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "1.001" "0.985" "0.986" "1.010" "0.978" "1.002" "0.984" "0.993" "0.730" "4328.1" "4333.0" "4262.6" "4267.4" "4371.8" "4234.6" "4338.2" "4257.6" "4297.8" "3157.4" "" "" "" "" "" "" "" "" "" "" "3906.9" "3342.2" "3296.8" "2873.7" "3646.8" "3614.3" "3680.0" "3081.2" "2898.8" "3157.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819136565778515185" "False" "High" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "0.000" "False" "197.106" "35" "28" "124" "27" "858" "95.3" "6.83" "341.52" "28" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "9" "1" "0.989" "0.935" "0.999" "0.992" "0.972" "1.019" "1.005" "0.980" "0.718" "7555.1" "7471.7" "7066.6" "7546.5" "7491.3" "7346.0" "7701.2" "7590.9" "7404.7" "5426.9" "" "" "" "" "" "" "" "" "" "" "6819.7" "5763.2" "5465.5" "5081.8" "6249.0" "6269.9" "6532.8" "5493.5" "4994.4" "5426.9" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8201100139023696608" "False" "High" "IsMasterProtein" "Q02952" "A-kinase anchor protein 12 OS=Homo sapiens OX=9606 GN=AKAP12 PE=1 SV=4" "0.000" "False" "196.832" "20" "28" "41" "28" "1782" "191.4" "4.41" "154.42" "28" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03832, Pf10522" "9590" "ENSG00000131016" "AKAP12" "hsa:9590; O00310; O00498; Q02952; Q4LE68; Q5SZ80; Q5TGN1; Q68D82; Q99970" "RHOD GTPase cycle; RHOF GTPase cycle" "G protein signaling pathways" "3" "0" "1.018" "1.034" "1.004" "0.975" "1.031" "1.051" "1.070" "1.039" "0.756" "2455.6" "2499.9" "2538.9" "2465.1" "2394.9" "2530.5" "2580.7" "2627.0" "2552.1" "1856.8" "" "" "" "" "" "" "" "" "" "" "2216.6" "1928.3" "1963.6" "1660.0" "1997.8" "2159.8" "2189.2" "1901.1" "1721.4" "1856.8" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7017874985935534894" "False" "High" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "0.000" "False" "195.532" "31" "36" "52" "36" "1134" "123.7" "5.66" "170.39" "36" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Neutrophil degranulation; Platelet degranulation ; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "18" "0" "1.047" "1.078" "1.100" "1.025" "1.062" "1.049" "1.054" "1.141" "0.758" "3101.9" "3246.3" "3342.8" "3410.7" "3180.8" "3293.7" "3254.6" "3270.6" "3538.3" "2350.5" "" "" "" "" "" "" "" "" "" "" "2800.0" "2504.0" "2585.4" "2296.8" "2653.3" "2811.2" "2760.8" "2366.9" "2386.6" "2350.5" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6674387397432112473" "False" "High" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "0.000" "False" "194.604" "44" "15" "149" "1" "445" "49.8" "4.89" "420.04" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; MHC class II antigen presentation; HCMV Early Events; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intraflagellar transport; Recycling pathway of L1; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "42" "18" "0.996" "0.940" "0.993" "1.017" "0.934" "0.998" "1.003" "0.933" "0.733" "6552.6" "6528.7" "6161.8" "6506.8" "6665.9" "6119.1" "6538.5" "6571.3" "6113.4" "4805.1" "" "" "" "" "" "" "" "" "" "" "5914.8" "5035.9" "4765.7" "4381.6" "5560.4" "5222.7" "5546.5" "4755.6" "4123.4" "4805.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619416957405686977" "False" "High" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "0.000" "False" "193.463" "40" "26" "68" "26" "788" "85.2" "4.30" "227.42" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "0.974" "1.022" "0.967" "0.957" "0.980" "0.978" "1.002" "0.992" "0.962" "5374.1" "5236.7" "5494.2" "5194.5" "5140.9" "5265.8" "5254.3" "5385.1" "5332.5" "5170.4" "" "" "" "" "" "" "" "" "" "" "4851.1" "4039.3" "4249.4" "3498.0" "4288.3" "4494.4" "4457.1" "3897.2" "3596.7" "5170.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8215909947984891721" "False" "High" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "0.000" "False" "193.257" "28" "29" "63" "29" "1152" "120.9" "5.43" "195.33" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "2" "0" "1.022" "0.980" "0.911" "0.973" "1.010" "0.978" "1.004" "0.955" "0.688" "2565.9" "2622.5" "2514.3" "2336.9" "2497.6" "2591.1" "2508.6" "2577.3" "2449.4" "1765.9" "" "" "" "" "" "" "" "" "" "" "2316.2" "2022.8" "1944.7" "1573.7" "2083.4" "2211.5" "2128.0" "1865.2" "1652.1" "1765.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5579729439990208910" "False" "High" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "0.000" "False" "191.493" "51" "17" "144" "14" "434" "47.1" "7.39" "444.16" "17" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "9" "2" "0.994" "1.067" "0.943" "0.969" "1.089" "0.960" "0.959" "1.092" "0.700" "6651.0" "6612.4" "7094.8" "6269.7" "6444.2" "7241.6" "6383.0" "6380.3" "7263.9" "4657.5" "" "" "" "" "" "" "" "" "" "" "6003.7" "5100.4" "5487.4" "4222.0" "5375.5" "6180.8" "5414.6" "4617.4" "4899.4" "4657.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6866488294459179487" "False" "High" "IsMasterProtein" "Q8NFC6" "Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2" "0.000" "False" "191.270" "12" "33" "45" "33" "3051" "330.3" "5.08" "162.31" "33" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf05205" "259282" "ENSG00000038219" "BOD1L1" "hsa:259282; Q6P0M8; Q8NFC6; Q96AL1; Q9H6G0; Q9NTD6; Q9P2L9" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "1.026" "1.003" "1.051" "1.018" "0.991" "0.995" "1.014" "1.044" "0.792" "2245.2" "2302.9" "2251.0" "2359.4" "2285.3" "2224.5" "2234.2" "2276.9" "2343.7" "1778.6" "" "" "" "" "" "" "" "" "" "" "2026.7" "1776.3" "1741.0" "1588.8" "1906.3" "1898.7" "1895.2" "1647.8" "1580.8" "1778.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646758734319931850" "False" "High" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "0.000" "False" "189.642" "47" "19" "54" "19" "572" "62.3" "6.38" "190.25" "19" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Recycling pathway of L1; CRMPs in Sema3A signaling" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "4" "0" "1.027" "1.096" "1.029" "1.031" "1.118" "1.040" "1.052" "1.099" "0.743" "2209.6" "2269.2" "2421.6" "2274.8" "2277.9" "2471.1" "2297.6" "2324.7" "2428.4" "1642.2" "" "" "" "" "" "" "" "" "" "" "1994.6" "1750.3" "1873.0" "1531.8" "1900.2" "2109.1" "1949.0" "1682.4" "1637.9" "1642.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8277375164580502172" "False" "High" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "0.000" "False" "189.397" "31" "36" "48" "36" "1233" "143.1" "7.64" "164.21" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "Estrogen-dependent gene expression; Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response" "22" "0" "1.001" "0.799" "0.946" "0.999" "0.803" "0.961" "0.964" "0.785" "0.668" "2816.2" "2820.4" "2249.3" "2664.8" "2812.9" "2261.3" "2705.2" "2713.6" "2210.1" "1882.4" "" "" "" "" "" "" "" "" "" "" "2542.1" "2175.5" "1739.7" "1794.5" "2346.4" "1930.0" "2294.8" "1963.8" "1490.7" "1882.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5530158233237029042" "False" "High" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "0.000" "False" "187.953" "26" "37" "47" "37" "1411" "162.4" "5.68" "163.65" "37" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "Toll Like Receptor 9 (TLR9) Cascade" "VEGFA-VEGFR2 signaling" "2" "0" "0.986" "0.996" "0.973" "1.029" "0.977" "1.011" "1.036" "0.982" "0.754" "2952.9" "2910.5" "2941.8" "2874.1" "3039.3" "2885.4" "2984.0" "3060.4" "2901.1" "2226.3" "" "" "" "" "" "" "" "" "" "" "2665.5" "2245.0" "2275.3" "1935.4" "2535.3" "2462.7" "2531.3" "2214.8" "1956.7" "2226.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-516006275001987462" "False" "High" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "0.000" "False" "187.856" "33" "29" "62" "29" "821" "92.8" "5.41" "212.49" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "11" "0" "1.025" "0.785" "0.969" "1.015" "0.802" "1.014" "1.021" "0.798" "0.840" "4307.2" "4414.6" "3382.0" "4175.7" "4373.0" "3453.4" "4366.9" "4396.4" "3435.4" "3618.2" "" "" "" "" "" "" "" "" "" "" "3888.0" "3405.2" "2615.7" "2811.9" "3647.8" "2947.6" "3704.4" "3181.6" "2317.1" "3618.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8288854614025876019" "False" "High" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "0.000" "False" "187.097" "72" "16" "118" "13" "255" "29.2" "4.74" "346.08" "16" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; TP53 Regulates Metabolic Genes; Regulation of HSF1-mediated heat shock response; HSF1 activation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; NADE modulates death signalling; Activation of BAD and translocation to mitochondria" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "26" "4" "1.001" "1.040" "0.988" "1.017" "1.086" "0.989" "1.004" "1.039" "0.710" "6212.2" "6216.2" "6459.7" "6136.2" "6318.6" "6749.0" "6141.1" "6236.5" "6453.7" "4411.6" "" "" "" "" "" "" "" "" "" "" "5607.6" "4794.9" "4996.2" "4132.1" "5270.7" "5760.4" "5209.4" "4513.3" "4353.0" "4411.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6480137070562712140" "False" "High" "IsMasterProtein" "Cont_Q2KJD0" "Tubulin beta-5 chain OS=Bos taurus OX=9913 GN=TUBB5 PE=2 SV=1" "0.000" "True" "186.113" "44" "15" "151" "3" "444" "49.6" "4.89" "406.49" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100022562; 100172938; 100303606; 100598146; 100689091; 100718713; 100918219; 100998701; 101034943; 101095657; 101129890; 101318992; 101341456; 101365832; 101593768; 101827904; 101925816; 101965993; 102168953; 102382532; 102506772; 102536943; 102568349; 102831964; 102882060; 102926495; 102963307; 103014346; 103053177; 103080542; 103205965; 103221819; 103261319; 103665004; 104666199; 105074100; 105087494; 105308138; 105498618; 105513957; 105553127; 105600022; 105704569; 105817283; 105855398; 105996956; 106553108; 106825507; 106966617; 107160457; 107498082; 108520633; 108522550; 109249509; 109693530; 203068; 22154; 29214; 396254; 471960; 474830; 574113; 615087; 733686" "ENSACCG00020016918; ENSAMEG00000014418; ENSANAG00000034194; ENSANIG00000003763; ENSAOWG00000004252; ENSBGRG00000008599; ENSBIXG00000008022; ENSBIXG00005015569; ENSBMSG00010013877; ENSBTAG00000006969; ENSCABG00000008181; ENSCAFG00000000443; ENSCAFG00040015599; ENSCAFG00845007927; ENSCANG00000012112; ENSCATG00000014335; ENSCCNG00000028823; ENSCGRG00000007995; ENSCGRG00001023930; ENSCGRG00015028239; ENSCHIG00000025610; ENSCJAG00000048479; ENSCMUG00000016892; ENSCPOG00000035463; ENSCRFG00000007002; ENSCSAG00000008279; ENSCWAG00000006690; ENSEASG00005019680; ENSFCAG00000027444; ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067; ENSGAGG00000007027; ENSGGOG00000022655; ENSJJAG00000024145; ENSLCNG00005007041; ENSMFAG00000044340; ENSMICG00000010647; ENSMLEG00000037482; ENSMMMG00000020216; ENSMMNG00015000200; ENSMMNG00015000533; ENSMMNG00015004763; ENSMMSG00000005300; ENSMMUG00000030028; ENSMNEG00000044824; ENSMODG00000023805; ENSMSIG00000015128; ENSMUSG00000001525; ENSNLEG00000005348; ENSOANG00000004061; ENSOARG00000011626; ENSPANG00000015954; ENSPCLG00000013695; ENSPCOG00000022809; ENSPCTG00005009625; ENSPEMG00000025556; ENSPLOG00000016488; ENSPPYG00000016419; ENSPSNG00000012487; ENSPTEG00000030284; ENSPTIG00000006316; ENSPTRG00000017675; ENSRBIG00000034281; ENSRFEG00010000368; ENSRNOG00000061216; ENSRNOG00055006845; ENSRNOG00060003580; ENSRNOG00065029671; ENSRROG00000035442; ENSSBOG00000020987; ENSSDAG00000016166; ENSSHAG00000028751; ENSSHBG00005000940; ENSSOCG00000016453; ENSSSCG00000001379; ENSSSCG00015022877; ENSSSCG00025077784; ENSSSCG00030060370; ENSSSCG00035060189; ENSSSCG00040067819; ENSSSCG00050020383; ENSSSCG00055030461; ENSSSCG00060047808; ENSSSCG00065051381; ENSSSCG00070024618; ENSSSUG00005002289; ENSSTOG00000023492; ENSSVLG00005006345; ENSTGEG00000009306; ENSTGEG00000012139; ENSTGUG00000029087; ENSTSYG00000035292; ENSUAMG00000026276; ENSUMAG00000019678; ENSUPAG00010003937; ENSVURG00010001582; ENSVVUG00000009892; ENSZLMG00000006871" "LOC101341456; LOC106553108; LOC111152509; LOC112622444; LOC114901775; LOC115493080; LOC116436919; TBB7; Tubb; TUBB; Tubb5; TUBB5" "A0A0B8RPP1; A0A0D9R7E7; A0A151MZH9; A0A1S3GEI3; A0A1U7R7I2; A0A1U7SI21; A0A1U7TVN8; A0A1V4L0F2; A0A1W7RC49; A0A218U794; A0A286XDY8; A0A2D4LT52; A0A2D4PSK3; A0A2I3MS98; A0A2J8NXA1; A0A2J8SJF9; A0A2K5EIS8; A0A2K5HGL3; A0A2K5KT86; A0A2K5WBU4; A0A2K5ZFW6; A0A2K6E8N3; A0A2K6G5S3; A0A2K6LAT7; A0A2K6Q336; A0A2K6SLG3; A0A2U3V2D1; A0A2U3WJT7; A0A2Y9EAZ4; A0A2Y9EP82; A0A2Y9HLQ0; A0A2Y9K0M9; A0A2Y9MS78; A0A340WI11; A0A341AY80; A0A384BFD0; A0A384C9R0; A0A387L8L1; A0A3Q7RLV2; A0A3Q7S184; A0A452G3S8; A0A452H2Z1; A0A452SPC5; A0A480TK33; A0A485NK51; A0A4D9DG40; A0A4W2C297; A0A4X2JR93; A0A5E4AVV9; A0A5N3VZ42; A0A5N3WG73; A0A5N4CSN6; A0A663FK44; A0A667GBL5; A0A669QEL9; A0A671DQJ6; A0A672TGM1; A0A673T1T3; A0A674HV74; A0A6B2F8Z8; A0A6B2F9Q6; A0A6I9ILN3; A0A6I9MI92; A0A6I9YS87; A0A6I9ZH14; A0A6J0V952; A0A6J0X5U3; A0A6J1VI28; A0A6J2LA47; A0A6J3H9X1; A0A6P3EF00; A0A6P3RZ49; A0A6P5RBI7; A0A6P6HAZ1; A0A6P7XJA2; A0A6P8P8N4; A0A6P9CC67; A0A6P9FE20; A0A7J7R527; A0A7J7RLA9; A0A7J8GU45; A0A7J8KJ46; A0A7N4PPV2; A0A811YN81; A0A8B7ATI1; A0A8B7EBT6; A0A8B7VFP4; A0A8B9M868; A0A8B9P6J0; A0A8B9X0N8; A0A8C0I1Y2; A0A8C0IPC0; A0A8C0SSP9; A0A8C3VZK5; A0A8C3XAR0; A0A8C4PT60; A0A8C5LKQ9; A0A8C6AUQ3; A0A8C6EXU6; A0A8C6FHM7; A0A8C6MWA3; A0A8C8XQA1; A0A8C9BZ32; A0A8C9I594; A0A8C9J767; A0A8C9USK8; A0A8D0FX24; A0A8D2B3E9; A0A8D2EVN1; A0A8D2GXX0; A0A8D2P6S2; A0A8I3N9K0; A0A8K1G105; A0A8U0NH48; A0A8U7NRV1; A0A9B0X0S4; A0A9F2WGG8; A0A9V1E7C8; A0A9W3GX28; A0A9X9LVU0; A0AA35K0A2; A5D9A3; A6KT85; aju:106966617; amj:102568349; asn:102382532; B1B178; bacu:103014346; bta:615087; caty:105600022; ccan:109693530; cdk:105087494; cfa:474830; cfr:102506772; cge:100689091; chx:102168953; cpoc:100718713; csab:103221819; csyr:103261319; dle:111170669; dord:105996956; F6TYN8; F7F082; fca:101095657; G1LKN6; G1R063; G3HQP8; G3SB76; gga:396254; ggo:101129890; gsh:117346094; hsa:203068; I3ND93; J3S5D8; L5KK71; M3X7Z9; maua:101827904; mcal:110312171; mcc:574113; mdo:100022562; mmu:22154; mmur:105855398; mni:105498618; mpuf:101674529; muo:115466267; nasi:112395403; nle:100598146; nss:113423183; nsu:110586671; oas:100303606; oro:101365832; P05218; P07437; P09244; P69893; P69895; P69897; P99024; pale:102882060; panu:100998701; pbi:103053177; pcad:102979859; pcoq:105817283; pdic:114493854; pgut:117667950; pon:100172938; ptg:102963307; ptr:471960; pvp:105308138; pvt:110090161; Q1XHT6; Q2KJD0; Q3TFB6; Q3THH9; Q3TIL1; Q3UAV4; Q3UF52; Q5R943; Q5SU16; Q5TM69; Q6P9X8; Q767L7; Q7JJU6; Q8WUC1; Q9CY33; ray:107498082; rbb:108520633; rbb:108522550; rno:29214; rro:104666199; S9WJD1; sbq:101034943; shr:100918219; ssc:733686; T1DHR5; tmu:101341456; tsr:106553108; U3FAQ9; U3FM57; umr:103665004; vpc:102536943; vvp:112913571; W5PPT6; zca:113927996" "Potential therapeutics for SARS; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease; HDAC6 interactions in the central nervous system" "57" "2" "0.922" "0.913" "0.895" "0.996" "0.938" "0.882" "1.016" "0.906" "0.712" "1276.4" "1176.7" "1165.2" "1142.2" "1270.9" "1196.7" "1126.1" "1296.4" "1156.3" "908.9" "" "" "" "" "" "" "" "" "" "" "1152.1" "907.6" "901.2" "769.2" "1060.1" "1021.4" "955.2" "938.2" "779.9" "908.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7479442399663165637" "False" "High" "IsMasterProtein" "Cont_P02769" "Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4" "0.000" "True" "183.878" "47" "29" "73" "28" "607" "69.2" "6.18" "236.10" "29" "stress response;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "280717" "" "ALB" "A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2" "" "" "0" "1" "1.180" "1.104" "1.112" "0.973" "1.487" "0.997" "1.012" "1.598" "0.853" "3067.7" "3618.9" "3388.0" "3412.4" "2985.7" "4562.8" "3057.7" "3104.1" "4903.6" "2615.4" "" "" "" "" "" "" "" "" "" "" "2769.1" "2791.4" "2620.4" "2297.9" "2490.6" "3894.4" "2593.8" "2246.4" "3307.4" "2615.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3650651295291502810" "False" "High" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "0.000" "False" "183.427" "15" "37" "54" "31" "2602" "278.0" "5.73" "172.54" "37" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "ISG15 antiviral mechanism" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome" "6" "0" "0.984" "0.897" "1.047" "0.941" "0.911" "1.028" "0.979" "0.894" "0.993" "1717.7" "1691.0" "1541.2" "1798.5" "1616.9" "1565.6" "1765.5" "1681.2" "1535.6" "1705.7" "" "" "" "" "" "" "" "" "" "" "1550.5" "1304.4" "1192.0" "1211.1" "1348.8" "1336.3" "1497.7" "1216.7" "1035.7" "1705.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9133260577685858014" "False" "High" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "0.000" "False" "181.922" "25" "21" "64" "21" "1097" "123.6" "4.94" "208.01" "21" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "vRNP Assembly" "" "1" "0" "0.971" "0.971" "0.967" "0.936" "0.989" "1.005" "0.954" "0.955" "0.771" "2830.2" "2748.3" "2749.0" "2736.0" "2648.8" "2798.9" "2843.1" "2699.0" "2704.2" "2182.9" "" "" "" "" "" "" "" "" "" "" "2554.7" "2119.9" "2126.2" "1842.4" "2209.5" "2388.9" "2411.7" "1953.3" "1823.9" "2182.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8012908085941337264" "False" "High" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "0.000" "False" "181.770" "41" "19" "79" "19" "543" "59.3" "7.65" "229.48" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "Formation of tubulin folding intermediates by CCT/TriC; RHOBTB1 GTPase cycle; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "9" "0" "0.972" "0.977" "0.972" "0.980" "0.978" "0.949" "0.988" "0.973" "0.735" "5083.9" "4939.6" "4965.3" "4942.3" "4984.6" "4970.9" "4825.5" "5021.7" "4946.4" "3736.2" "" "" "" "" "" "" "" "" "" "" "4589.1" "3810.2" "3840.3" "3328.1" "4157.9" "4242.7" "4093.4" "3634.1" "3336.3" "3736.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5950667386624240413" "False" "High" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "0.000" "False" "179.713" "18" "39" "50" "36" "2364" "274.4" "5.57" "155.08" "39" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; COPI-mediated anterograde transport; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Signaling by FLT3 fusion proteins" "TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "2" "1.045" "1.037" "1.068" "1.060" "1.049" "1.022" "1.034" "1.084" "0.843" "1855.0" "1938.6" "1923.2" "1980.5" "1966.3" "1945.4" "1896.3" "1917.1" "2009.9" "1562.9" "" "" "" "" "" "" "" "" "" "" "1674.5" "1495.3" "1487.5" "1333.7" "1640.3" "1660.4" "1608.6" "1387.4" "1355.7" "1562.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6718063858029524947" "False" "High" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "0.000" "False" "179.705" "48" "18" "76" "14" "445" "50.6" "6.47" "233.92" "18" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs" "" "2" "5" "0.969" "1.063" "1.008" "1.005" "1.145" "0.976" "1.008" "1.131" "0.779" "4209.8" "4077.4" "4475.3" "4243.4" "4229.9" "4818.5" "4107.2" "4242.8" "4763.2" "3280.5" "" "" "" "" "" "" "" "" "" "" "3800.1" "3145.1" "3461.4" "2857.5" "3528.4" "4112.7" "3484.0" "3070.5" "3212.7" "3280.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9169618704545618170" "False" "High" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "0.000" "False" "176.011" "55" "19" "114" "16" "364" "39.4" "8.09" "382.78" "19" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; Platelet degranulation" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "3" "1.006" "1.101" "1.048" "1.085" "1.141" "1.106" "1.070" "1.160" "0.740" "7034.2" "7073.7" "7747.0" "7375.2" "7633.1" "8025.9" "7783.1" "7526.2" "8158.0" "5203.3" "" "" "" "" "" "" "" "" "" "" "6349.5" "5456.2" "5991.8" "4966.4" "6367.2" "6850.2" "6602.3" "5446.6" "5502.5" "5203.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2426861074950700078" "False" "High" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "0.000" "False" "175.361" "24" "22" "60" "22" "1058" "117.8" "5.76" "197.16" "22" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "5" "0" "0.887" "1.314" "0.926" "0.853" "1.287" "0.830" "0.680" "1.304" "2.080" "2535.3" "2247.7" "3330.5" "2348.9" "2161.6" "3262.7" "2104.6" "1723.6" "3306.6" "5272.7" "" "" "" "" "" "" "" "" "" "" "2288.5" "1733.7" "2575.9" "1581.8" "1803.2" "2784.8" "1785.3" "1247.3" "2230.2" "5272.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8321804652329171157" "False" "High" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "0.000" "False" "172.599" "35" "33" "85" "33" "866" "101.2" "7.42" "244.62" "33" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "0" "1.008" "0.979" "1.026" "0.970" "1.020" "1.002" "0.999" "0.992" "0.730" "4943.6" "4984.4" "4841.9" "5070.4" "4797.1" "5042.9" "4953.9" "4940.8" "4904.3" "3610.1" "" "" "" "" "" "" "" "" "" "" "4462.5" "3844.7" "3744.9" "3414.4" "4001.5" "4304.2" "4202.3" "3575.6" "3307.9" "3610.1" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2402053168044673171" "False" "High" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "0.000" "False" "172.262" "37" "14" "61" "14" "529" "56.5" "5.40" "191.78" "14" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "8" "0" "1.041" "1.169" "1.051" "1.036" "1.219" "0.979" "1.020" "1.283" "0.639" "1709.6" "1779.0" "1998.8" "1796.1" "1771.8" "2084.5" "1674.2" "1743.9" "2193.3" "1091.6" "" "" "" "" "" "" "" "" "" "" "1543.2" "1372.2" "1546.0" "1209.5" "1478.0" "1779.1" "1420.2" "1262.0" "1479.3" "1091.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5279545747934132258" "False" "High" "IsMasterProtein" "P04350" "Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2" "0.000" "False" "171.880" "45" "15" "130" "4" "444" "49.6" "4.88" "359.81" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10382" "ENSG00000104833" "TUBB4A" "B3KQP4; hsa:10382; P04350; Q969E5" "RHO GTPases Activate Formins; HCMV Early Events; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "41" "0" "1.040" "0.982" "0.985" "1.058" "1.029" "1.039" "1.032" "1.036" "0.847" "814.0" "846.3" "799.2" "802.0" "861.4" "837.8" "845.6" "839.7" "843.2" "689.6" "" "" "" "" "" "" "" "" "" "" "734.7" "652.8" "618.1" "540.0" "718.5" "715.1" "717.3" "607.7" "568.8" "689.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625337675714682058" "False" "High" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "0.000" "False" "171.038" "29" "27" "44" "27" "963" "109.6" "6.51" "144.93" "27" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; Insulin processing; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "11" "0" "0.961" "0.753" "0.945" "0.977" "0.773" "0.996" "0.991" "0.766" "0.795" "2512.1" "2414.9" "1890.5" "2374.9" "2454.0" "1940.9" "2501.6" "2490.6" "1925.0" "1997.3" "" "" "" "" "" "" "" "" "" "" "2267.6" "1862.8" "1462.2" "1599.3" "2047.0" "1656.6" "2122.1" "1802.4" "1298.4" "1997.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528371413836643526" "False" "High" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "0.000" "False" "170.420" "43" "27" "67" "24" "711" "73.1" "7.30" "223.74" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "Pre-implantation embryo" "3" "3" "0.994" "0.907" "0.970" "0.979" "0.925" "0.982" "1.015" "0.891" "0.685" "4452.8" "4428.2" "4039.3" "4320.2" "4361.0" "4118.9" "4372.9" "4517.4" "3966.0" "3049.2" "" "" "" "" "" "" "" "" "" "" "4019.5" "3415.7" "3124.1" "2909.2" "3637.8" "3515.6" "3709.5" "3269.2" "2675.0" "3049.2" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4377208032786879179" "False" "High" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "0.000" "False" "169.718" "73" "15" "69" "14" "240" "26.8" "4.73" "244.50" "15" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "XBP1(S) activates chaperone genes" "IL-18 signaling pathway" "2" "1" "1.025" "1.164" "0.964" "0.995" "1.161" "1.020" "1.117" "1.138" "0.774" "5915.4" "6061.4" "6887.4" "5703.3" "5886.6" "6866.5" "6034.5" "6610.4" "6733.9" "4577.3" "" "" "" "" "" "" "" "" "" "" "5339.6" "4675.4" "5327.0" "3840.6" "4910.4" "5860.6" "5119.0" "4783.9" "4541.9" "4577.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256091368978195991" "False" "High" "IsMasterProtein" "Q32MZ4" "Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2" "0.000" "False" "168.464" "33" "22" "34" "21" "808" "89.2" "4.65" "128.53" "22" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09738" "9208" "ENSG00000124831" "LRRFIP1" "E9PGZ2; hsa:9208; O75766; O75799; Q32MZ4; Q32MZ5; Q53T49; Q6PKG2; Q9Y607" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "IL-18 signaling pathway; 2q37 copy number variation syndrome" "5" "0" "0.966" "0.960" "0.978" "0.920" "0.922" "0.980" "1.052" "0.954" "0.869" "2409.3" "2326.9" "2313.1" "2356.1" "2217.3" "2221.6" "2360.2" "2535.6" "2298.8" "2093.5" "" "" "" "" "" "" "" "" "" "" "2174.8" "1794.8" "1789.1" "1586.6" "1849.6" "1896.1" "2002.1" "1835.0" "1550.5" "2093.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8533826193911874289" "False" "High" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "0.000" "False" "167.681" "23" "28" "62" "28" "1230" "136.3" "5.78" "190.76" "28" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623, Pf13513" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "Endoderm differentiation" "4" "0" "1.016" "1.038" "1.045" "0.982" "1.043" "1.008" "1.004" "1.031" "0.692" "5370.1" "5454.1" "5573.0" "5613.9" "5272.6" "5603.4" "5413.0" "5389.4" "5535.0" "3718.7" "" "" "" "" "" "" "" "" "" "" "4847.5" "4207.0" "4310.4" "3780.4" "4398.2" "4782.6" "4591.7" "3900.2" "3733.3" "3718.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5926930809007955556" "False" "High" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "0.000" "False" "167.598" "29" "22" "54" "21" "858" "96.8" "5.39" "170.83" "22" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "" "2" "1" "0.926" "1.040" "0.939" "0.910" "0.988" "0.947" "0.906" "0.965" "1.489" "3533.9" "3272.7" "3673.8" "3318.4" "3217.4" "3490.8" "3348.1" "3201.7" "3411.8" "5263.7" "" "" "" "" "" "" "" "" "" "" "3189.9" "2524.4" "2841.5" "2234.6" "2683.8" "2979.5" "2840.1" "2317.0" "2301.2" "5263.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8891268094734712955" "False" "High" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "0.000" "False" "164.851" "25" "35" "53" "35" "1488" "152.0" "9.04" "175.16" "35" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "0.944" "1.272" "0.950" "1.019" "1.247" "1.000" "0.982" "1.199" "0.911" "3649.7" "3446.0" "4643.8" "3468.6" "3717.5" "4550.9" "3651.3" "3583.8" "4377.6" "3325.9" "" "" "" "" "" "" "" "" "" "" "3294.5" "2658.1" "3591.7" "2335.7" "3101.0" "3884.3" "3097.3" "2593.6" "2952.7" "3325.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5211801014996619812" "False" "High" "IsMasterProtein" "O43143" "ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "0.000" "False" "164.676" "29" "23" "60" "22" "795" "90.9" "7.46" "179.51" "23" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.025" "0.965" "0.972" "1.012" "0.943" "1.014" "1.040" "0.954" "0.557" "4177.7" "4280.1" "4029.6" "4059.3" "4228.3" "3940.1" "4236.3" "4346.0" "3986.6" "2325.2" "" "" "" "" "" "" "" "" "" "" "3771.1" "3301.5" "3116.7" "2733.5" "3527.1" "3362.9" "3593.6" "3145.2" "2688.9" "2325.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1011353078992681906" "False" "High" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "0.000" "False" "162.842" "32" "25" "52" "25" "904" "101.8" "5.52" "167.16" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome" "11" "0" "1.018" "0.760" "0.991" "1.020" "0.810" "1.018" "0.989" "0.768" "0.895" "2998.5" "3052.6" "2280.2" "2970.8" "3058.5" "2430.2" "3051.9" "2965.7" "2304.3" "2682.2" "" "" "" "" "" "" "" "" "" "" "2706.7" "2354.6" "1763.6" "2000.5" "2551.3" "2074.2" "2588.9" "2146.3" "1554.2" "2682.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6996937188134376608" "False" "High" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "0.000" "False" "157.945" "25" "29" "79" "29" "1140" "126.9" "5.26" "217.59" "29" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "14" "0" "0.984" "1.018" "0.991" "0.983" "1.021" "0.985" "0.971" "1.035" "0.730" "4751.1" "4676.1" "4834.3" "4707.6" "4672.0" "4851.9" "4677.6" "4614.7" "4919.4" "3466.8" "" "" "" "" "" "" "" "" "" "" "4288.7" "3606.9" "3739.0" "3170.1" "3897.2" "4141.2" "3967.9" "3339.6" "3318.1" "3466.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6605193621902288169" "False" "High" "IsMasterProtein" "Cont_P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "0.000" "True" "157.003" "33" "17" "32" "13" "639" "65.4" "8.00" "118.78" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "Formation of the cornified envelope" "" "2" "2" "1.050" "1.964" "1.256" "0.666" "1.234" "0.931" "1.232" "0.678" "0.550" "1562.4" "1640.0" "3068.8" "1963.0" "1040.3" "1928.0" "1453.9" "1924.6" "1059.6" "860.1" "" "" "" "" "" "" "" "" "" "" "1410.3" "1265.0" "2373.5" "1321.9" "867.8" "1645.6" "1233.4" "1392.8" "714.7" "860.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964707792463719030" "False" "High" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "0.000" "False" "155.452" "37" "18" "57" "18" "548" "62.9" "6.25" "188.06" "18" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf20917" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Cytosolic tRNA aminoacylation" "Photodynamic therapy-induced unfolded protein response" "2" "0" "1.030" "0.864" "1.081" "1.039" "0.934" "1.036" "1.049" "0.903" "0.717" "2841.0" "2926.5" "2455.5" "3071.5" "2952.4" "2652.6" "2942.3" "2980.1" "2564.6" "2036.9" "" "" "" "" "" "" "" "" "" "" "2564.5" "2257.4" "1899.2" "2068.3" "2462.8" "2264.0" "2495.9" "2156.6" "1729.8" "2036.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3959572878681588940" "False" "High" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "0.000" "False" "154.956" "37" "19" "69" "19" "556" "60.3" "6.11" "205.84" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "8" "0" "0.988" "1.030" "0.938" "0.949" "0.977" "0.942" "0.988" "0.931" "0.712" "3237.9" "3197.8" "3335.1" "3037.9" "3072.9" "3162.6" "3051.6" "3200.2" "3015.9" "2304.7" "" "" "" "" "" "" "" "" "" "" "2922.7" "2466.6" "2579.5" "2045.7" "2563.3" "2699.4" "2588.6" "2316.0" "2034.2" "2304.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7970699774180839953" "False" "High" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "0.000" "False" "154.443" "46" "18" "52" "18" "463" "51.1" "5.64" "157.18" "18" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "HATs acetylate histones; Telomere Extension By Telomerase" "" "2" "0" "1.035" "1.000" "1.020" "1.045" "1.050" "1.018" "0.993" "1.028" "1.016" "2338.0" "2418.9" "2338.2" "2384.3" "2444.2" "2454.4" "2380.6" "2321.5" "2403.1" "2375.8" "" "" "" "" "" "" "" "" "" "" "2110.5" "1865.8" "1808.4" "1605.6" "2038.8" "2094.8" "2019.4" "1680.0" "1620.8" "2375.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7048585715635486560" "False" "High" "IsMasterProtein" "Q13885" "Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1" "0.000" "False" "154.251" "32" "12" "139" "1" "445" "49.9" "4.89" "366.55" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7280" "ENSG00000137267" "TUBB2A" "hsa:7280; Q13885; Q6FGZ8; Q8IWR2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; MHC class II antigen presentation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; HCMV Early Events; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "35" "0" "0.983" "1.001" "0.740" "1.175" "1.099" "1.008" "1.161" "1.041" "0.887" "94.5" "92.9" "94.6" "69.9" "111.0" "103.9" "95.2" "109.7" "98.4" "83.8" "" "" "" "" "" "" "" "" "" "" "85.3" "71.7" "73.2" "47.1" "92.6" "88.7" "80.8" "79.4" "66.4" "83.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5988193438521902409" "False" "High" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "0.000" "False" "154.157" "22" "25" "45" "25" "1264" "140.4" "7.59" "156.89" "25" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Cytosolic tRNA aminoacylation" "Amino acid metabolism" "2" "0" "0.970" "0.748" "0.953" "0.951" "0.763" "0.994" "0.962" "0.767" "1.221" "2901.4" "2814.7" "2169.9" "2764.2" "2758.1" "2214.6" "2883.8" "2791.6" "2226.0" "3543.3" "" "" "" "" "" "" "" "" "" "" "2619.0" "2171.1" "1678.2" "1861.4" "2300.7" "1890.2" "2446.2" "2020.3" "1501.4" "3543.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547781430018805415" "False" "High" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "0.000" "False" "153.912" "41" "18" "55" "18" "505" "56.7" "6.35" "187.20" "18" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "Prion disease pathway" "4" "0" "0.984" "1.151" "0.961" "1.010" "1.245" "0.966" "0.902" "1.145" "2.561" "2695.5" "2652.1" "3101.9" "2590.6" "2721.9" "3356.1" "2605.2" "2432.0" "3085.6" "6904.3" "" "" "" "" "" "" "" "" "" "" "2433.1" "2045.7" "2399.1" "1744.5" "2270.5" "2864.5" "2209.9" "1760.0" "2081.2" "6904.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250102899765152791" "False" "High" "IsMasterProtein" "Q9BVA1" "Tubulin beta-2B chain OS=Homo sapiens OX=9606 GN=TUBB2B PE=1 SV=1" "0.000" "False" "153.883" "32" "12" "139" "1" "445" "49.9" "4.89" "363.41" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "347733" "ENSG00000137285" "TUBB2B" "A8K068; hsa:347733; Q9BVA1" "Prefoldin mediated transfer of substrate to CCT/TriC; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recycling pathway of L1; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Assembly and cell surface presentation of NMDA receptors; Intraflagellar transport; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "35" "0" "0.584" "0.984" "0.628" "0.813" "0.865" "0.881" "1.013" "0.955" "0.580" "59.2" "34.6" "58.3" "37.2" "48.1" "51.2" "52.2" "59.9" "56.5" "34.3" "" "" "" "" "" "" "" "" "" "" "53.4" "26.7" "45.1" "25.0" "40.1" "43.7" "44.3" "43.4" "38.1" "34.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5868182849043771837" "False" "High" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "0.000" "False" "152.058" "35" "12" "71" "12" "440" "48.1" "5.08" "243.91" "12" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "XBP1(S) activates chaperone genes; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "5" "0" "0.993" "0.874" "0.968" "0.998" "1.017" "0.940" "0.974" "0.922" "0.759" "2862.9" "2842.6" "2502.3" "2772.3" "2858.3" "2911.7" "2691.9" "2789.4" "2640.7" "2173.6" "" "" "" "" "" "" "" "" "" "" "2584.2" "2192.6" "1935.4" "1866.9" "2384.3" "2485.2" "2283.5" "2018.7" "1781.1" "2173.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2868702294912813046" "False" "High" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4" "0.000" "False" "151.304" "61" "13" "81" "13" "249" "26.7" "6.90" "294.36" "13" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "7167" "ENSG00000111669" "TPI1" "B7Z5D8; D3DUS9; hsa:7167; P00938; P60174; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5" "Glycolysis; Gluconeogenesis" "Fatty acid beta-oxidation; Cori cycle; HIF1A and PPARG regulation of glycolysis; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "10" "0" "0.990" "1.083" "0.980" "1.037" "1.072" "1.064" "1.030" "1.044" "0.806" "5202.0" "5150.4" "5632.9" "5099.6" "5392.4" "5574.0" "5535.2" "5360.1" "5433.3" "4194.9" "" "" "" "" "" "" "" "" "" "" "4695.7" "3972.7" "4356.7" "3434.1" "4498.2" "4757.5" "4695.4" "3879.0" "3664.7" "4194.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2399497510241032173" "False" "High" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "0.000" "False" "149.817" "34" "18" "60" "18" "553" "59.7" "9.13" "197.17" "18" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "7" "0" "1.123" "1.225" "1.074" "1.068" "1.206" "1.110" "1.078" "1.279" "0.696" "3235.2" "3633.7" "3962.1" "3474.3" "3455.3" "3901.3" "3590.3" "3488.8" "4137.3" "2252.9" "" "" "" "" "" "" "" "" "" "" "2920.3" "2802.8" "3064.4" "2339.6" "2882.3" "3329.8" "3045.6" "2524.8" "2790.6" "2252.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3283541064302857350" "False" "High" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "0.000" "False" "148.930" "23" "24" "40" "24" "1304" "145.7" "7.09" "134.83" "24" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; 10q11.21q11.23 copy number variation syndrome" "5" "0" "0.947" "1.162" "0.969" "0.956" "1.154" "0.909" "0.939" "1.102" "0.951" "1675.8" "1586.4" "1946.7" "1623.6" "1601.9" "1933.3" "1524.1" "1574.3" "1846.7" "1594.3" "" "" "" "" "" "" "" "" "" "" "1512.7" "1223.7" "1505.6" "1093.3" "1336.2" "1650.1" "1292.9" "1139.3" "1245.6" "1594.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1213395878895108528" "False" "High" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "0.000" "False" "146.914" "36" "24" "81" "19" "577" "67.8" "6.40" "256.29" "24" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by ALK fusions and activated point mutants" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "10" "5" "1.010" "1.166" "1.033" "1.006" "1.191" "1.019" "0.990" "1.187" "0.725" "4832.2" "4878.9" "5634.1" "4990.1" "4861.8" "5756.2" "4924.8" "4784.5" "5736.8" "3502.3" "" "" "" "" "" "" "" "" "" "" "4361.9" "3763.3" "4357.7" "3360.3" "4055.5" "4913.0" "4177.6" "3462.5" "3869.4" "3502.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1156142612126302656" "False" "High" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "0.000" "False" "145.223" "18" "26" "44" "25" "1512" "170.5" "7.33" "137.27" "26" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180, Pf20974" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "6" "1" "0.975" "0.960" "1.002" "0.966" "0.939" "0.939" "0.771" "0.962" "3.435" "2289.2" "2231.1" "2197.8" "2294.6" "2212.5" "2149.8" "2148.9" "1764.1" "2201.2" "7864.4" "" "" "" "" "" "" "" "" "" "" "2066.4" "1720.9" "1699.9" "1545.2" "1845.5" "1834.9" "1822.9" "1276.7" "1484.7" "7864.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2586862151232699530" "False" "High" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "0.000" "False" "145.097" "38" "22" "79" "22" "508" "57.1" "4.87" "256.34" "22" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling; Chylomicron assembly; VLDL assembly; LDL remodeling" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "13" "0" "1.008" "1.006" "0.955" "1.001" "1.020" "0.985" "1.027" "0.998" "0.748" "6005.5" "6055.7" "6043.8" "5737.1" "6012.0" "6123.7" "5914.8" "6167.4" "5992.3" "4494.4" "" "" "" "" "" "" "" "" "" "" "5421.0" "4671.0" "4674.5" "3863.4" "5015.0" "5226.6" "5017.4" "4463.3" "4041.8" "4494.4" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256395688163039861" "False" "High" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "0.000" "False" "144.951" "17" "34" "46" "34" "2136" "244.4" "6.06" "133.31" "34" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149, Pf21188" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2q11.2 copy number variation syndrome" "3" "0" "1.030" "0.871" "1.029" "0.980" "0.844" "0.983" "1.009" "0.881" "0.920" "1367.4" "1409.1" "1190.9" "1407.2" "1339.9" "1154.8" "1344.1" "1380.0" "1204.4" "1258.0" "" "" "" "" "" "" "" "" "" "" "1234.3" "1086.9" "921.1" "947.6" "1117.7" "985.6" "1140.2" "998.7" "812.4" "1258.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7326537803977903766" "False" "High" "IsMasterProtein" "P02786" "Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2" "0.000" "False" "144.451" "30" "22" "50" "22" "760" "84.8" "6.61" "166.45" "22" "stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf02225, Pf04253, Pf04389" "7037" "ENSG00000072274" "TFRC" "D3DXB0; hsa:7037; P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; RND1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; RHOH GTPase cycle" "Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome; Iron metabolism disorders" "21" "0" "0.955" "0.814" "1.015" "0.999" "0.866" "1.012" "1.040" "0.848" "0.828" "3557.5" "3398.3" "2896.5" "3612.4" "3554.2" "3079.9" "3598.4" "3698.2" "3018.0" "2944.4" "" "" "" "" "" "" "" "" "" "" "3211.3" "2621.3" "2240.3" "2432.6" "2964.8" "2628.8" "3052.5" "2676.4" "2035.6" "2944.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6681537936157474887" "False" "High" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "0.000" "False" "143.915" "42" "25" "54" "24" "585" "69.0" "5.87" "172.36" "25" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle" "" "3" "1" "1.008" "1.036" "1.004" "0.952" "1.033" "0.960" "0.902" "1.019" "0.886" "3958.1" "3987.9" "4099.9" "3974.3" "3769.0" "4088.3" "3798.3" "3570.6" "4035.2" "3506.8" "" "" "" "" "" "" "" "" "" "" "3572.8" "3076.0" "3171.0" "2676.3" "3143.9" "3489.4" "3222.0" "2584.0" "2721.7" "3506.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6880355764133463335" "False" "High" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "0.000" "False" "143.641" "16" "25" "41" "25" "1616" "183.1" "7.75" "129.45" "25" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; Nuclear events stimulated by ALK signaling in cancer" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Spina bifida" "13" "0" "1.013" "0.807" "1.008" "0.979" "0.837" "0.985" "1.038" "0.857" "0.787" "2088.9" "2116.5" "1686.2" "2106.1" "2044.6" "1748.2" "2057.9" "2167.9" "1791.1" "1643.9" "" "" "" "" "" "" "" "" "" "" "1885.6" "1632.6" "1304.2" "1418.2" "1705.5" "1492.1" "1745.7" "1568.9" "1208.1" "1643.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-806880739347862445" "False" "High" "IsMasterProtein" "Q71U36" "Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1" "0.000" "False" "143.548" "49" "17" "144" "1" "451" "50.1" "5.06" "431.57" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7846" "ENSG00000167552" "TUBA1A" "A8K0B8; G3V1U9; hsa:7846; P04687; P05209; Q71U36" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; The role of GTSE1 in G2/M progression after G2 checkpoint; HCMV Early Events; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Recycling pathway of L1; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Sealing of the nuclear envelope (NE) by ESCRT-III; RHO GTPases activate IQGAPs; Intraflagellar transport; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; PAFAH1B1 copy number variation" "42" "1" "1.056" "0.953" "0.969" "1.054" "0.989" "0.966" "0.970" "1.033" "0.877" "154.2" "162.9" "147.0" "149.5" "162.6" "152.6" "149.1" "149.6" "159.3" "135.3" "" "" "" "" "" "" "" "" "" "" "139.2" "125.7" "113.7" "100.7" "135.7" "130.2" "126.5" "108.3" "107.5" "135.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3930283768056647308" "False" "High" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "0.000" "False" "143.431" "43" "25" "74" "25" "543" "62.6" "6.80" "216.92" "25" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "VEGFA-VEGFR2 signaling" "3" "0" "0.985" "0.914" "0.958" "0.982" "0.936" "0.991" "1.010" "0.894" "0.849" "4599.2" "4531.6" "4201.8" "4405.0" "4518.5" "4302.7" "4558.6" "4644.1" "4111.5" "3906.3" "" "" "" "" "" "" "" "" "" "" "4151.5" "3495.4" "3249.8" "2966.4" "3769.2" "3672.4" "3867.0" "3360.9" "2773.2" "3906.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9142633453092605073" "False" "High" "IsMasterProtein" "Cont_P63103" "14-3-3 protein zeta/delta OS=Bos taurus OX=9913 GN=YWHAZ PE=1 SV=1" "0.000" "True" "143.031" "57" "11" "103" "7" "245" "27.7" "4.79" "325.95" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "100030704; 100056060; 100127113; 100173609; 100411134; 100484483; 100596460; 100672224; 100727182; 100913480; 100977477; 101012101; 101021050; 101151099; 101331119; 101351914; 101384625; 101687663; 101721954; 101968271; 102019696; 102115184; 102175223; 102283808; 102742022; 102765675; 103004481; 103085559; 103121925; 103191924; 103261347; 103732836; 105005492; 105302907; 105476048; 105504209; 105542098; 105586543; 105719669; 105869900; 106847839; 107142838; 107512228; 109277999; 109382800; 109568481; 109697135; 287022; 472830; 475864; 709723; 7534; 780440" "ENSAMEG00000000328; ENSANAG00000027160; ENSBGRG00000009704; ENSBIXG00000019500; ENSBIXG00005001276; ENSBMSG00010017904; ENSBTAG00000000236; ENSCAFG00000000580; ENSCAFG00845028920; ENSCANG00000043345; ENSCATG00000024186; ENSCCAG00000037757; ENSCCNG00000015730; ENSCHIG00000020223; ENSCJAG00000015844; ENSCLAG00000004303; ENSCPOG00000040522; ENSCWAG00000015721; ENSDLEG00000002530; ENSEASG00005002806; ENSECAG00000021882; ENSFCAG00000037073; ENSG00000164924; ENSGGOG00000022133; ENSHGLG00100048437; ENSLAFG00000004944; ENSMFAG00000001740; ENSMICG00000034946; ENSMLEG00000033187; ENSMMMG00000016188; ENSMMNG00015011551; ENSMMSG00000002669; ENSMMUG00000006489; ENSMNEG00000041365; ENSMODG00000006158; ENSMPUG00000015158; ENSNGAG00000006289; ENSNLEG00000030006; ENSPANG00000010317; ENSPANG00000042694; ENSPEMG00000021714; ENSPPAG00000038734; ENSPPYG00000018791; ENSPSMG00000012736; ENSPSNG00000018640; ENSPTEG00000005862; ENSPTIG00000021410; ENSPTRG00000048115; ENSRFEG00010019368; ENSSBOG00000021820; ENSSDAG00000019504; ENSSHAG00000012671; ENSSSCG00000006062; ENSSSCG00015031811; ENSSSCG00025071491; ENSSSCG00035013965; ENSSSCG00045030109; ENSSSCG00050034502; ENSSSCG00055001784; ENSSSCG00060049326; ENSSSCG00070011887; ENSSSUG00005013206; ENSSTOG00000023864; ENSSVLG00005003330; ENSTSYG00000026493; ENSTTRG00000015906; ENSUAMG00000024432; ENSUMAG00000017568; ENSVURG00010007014; ENSVVUG00000013173" "LOC101351914; LOC111146608; Ywhaz; YWHAZ" "A0A096NQ71; A0A097C2Z1; A0A1D5QAJ7; A0A1S3ABR1; A0A1U7TL92; A0A250XWX3; A0A286XIL7; A0A2I2UD77; A0A2I3GBB0; A0A2J8PMJ1; A0A2J8UFH0; A0A2K5DCH7; A0A2K5KE38; A0A2K5L5H7; A0A2K5SHP3; A0A2K5TVK5; A0A2K5YR93; A0A2K6DL02; A0A2K6SRG4; A0A2R9BQD0; A0A2U3W322; A0A2U3YQG6; A0A2U4AHZ7; A0A2Y9GYG0; A0A2Y9JAB1; A0A2Y9PAR8; A0A2Y9QK13; A0A340XXA5; A0A344MNR9; A0A383ZE89; A0A384BYY2; A0A3Q7NYD6; A0A3Q7S418; A0A452SHE3; A0A480PLY3; A0A4W2CSD8; A0A4X1TV95; A0A4X2KB08; A0A518J2H6; A0A5E4AK25; A0A671FTZ7; A0A673UG86; A0A6B0SHT8; A0A6D2XVW1; A0A6J0W154; A0A6J1ZUX6; A0A6J2B9D9; A0A6J2NBP1; A0A6J3FPA9; A0A6P3J5F7; A0A6P3R2S0; A0A6P5CUI6; A0A6P5ISH5; A0A6P6HS74; A0A7J7TL19; A0A7J7VNU9; A0A7J8C4Y7; A0A7J8DUV8; A0A7N4P7P6; A0A7N5KS25; A0A8B6ZD59; A0A8B7G6A9; A0A8B7RAL2; A0A8B8VLP3; A0A8B9X1D7; A0A8C2UZS6; A0A8C3WSB1; A0A8C4KZ72; A0A8C5ZR25; A0A8C6BH51; A0A8C6CXQ8; A0A8C6QKN2; A0A8C8U9V5; A0A8C8ZIR5; A0A8C9E7Q2; A0A8C9GP54; A0A8C9KQT4; A0A8C9Q7D7; A0A8D2CLR5; A0A8I3Q1P7; A0A8J8XBY4; A0A8J8Y9Q2; A0A8P0S6K0; A0A9V1GJ83; A0A9X9LZ30; A8K1N0; aju:106980045; aml:100484483; B7Z465; bacu:103004481; bbis:105005492; biu:109568481; bom:102283808; bta:287022; cang:105504209; caty:105586543; ccan:109697135; cfa:475864; chx:102175223; cjc:100411134; cpoc:100727182; csyr:103261347; D0PNI1; dle:111180376; elk:111146608; F6XEB4; F7BS95; F7EFF6; F7G9D2; F7HBD4; fca:100127113; G3RS45; G3SV87; G5AP01; G7MZV8; G7PCF6; ggo:101151099; hai:109382800; hgl:101721954; hsa:7534; I3N206; K7DDM2; L5M3G8; lav:100672224; lve:103085559; lww:102742022; M3WVC7; M3YUN9; mcc:709723; mcf:102115184; mdo:100030704; mleu:105542098; mmur:105869900; mni:105476048; mpuf:101687663; myd:102765675; ngi:103732836; nle:100596460; nsu:110579154; oro:101384625; P29213; P29312; P63103; P63104; panu:101012101; panu:101021050; pcoo:112859599; pcw:110196285; pdic:114514896; pon:100173609; pps:100977477; ptg:102966103; ptr:472830; pvp:105302907; Q32P43; Q3ZCF9; Q5R651; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; ray:107512228; sbq:101047958; shr:100913480; tmu:101351914; U3E3R3; umr:103661509; vvp:112916971; zca:113910054" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Activation of BAD and translocation to mitochondria ; Negative regulation of NOTCH4 signaling; TP53 Regulates Metabolic Genes; Interleukin-3, Interleukin-5 and GM-CSF signaling; Activation of BAD and translocation to mitochondria ; Rap1 signalling; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Interleukin-3, Interleukin-5 and GM-CSF signaling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling" "Calcium regulation in cardiac cell; Cell cycle; Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; SIDS susceptibility pathways; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Calcium regulation in cardiac cells" "40" "0" "0.978" "0.972" "0.980" "1.019" "1.110" "0.988" "1.015" "1.084" "0.730" "2297.2" "2247.7" "2233.4" "2250.4" "2339.7" "2550.0" "2268.6" "2330.6" "2491.2" "1677.5" "" "" "" "" "" "" "" "" "" "" "2073.6" "1733.7" "1727.4" "1515.4" "1951.7" "2176.5" "1924.4" "1686.6" "1680.3" "1677.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7448021442665095265" "False" "High" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "0.000" "False" "142.792" "24" "30" "38" "30" "1197" "135.6" "8.43" "123.38" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "Retinoblastoma gene in cancer" "3" "0" "0.992" "0.781" "0.926" "1.022" "0.806" "1.014" "0.917" "0.792" "1.806" "2397.3" "2379.1" "1872.8" "2221.1" "2449.0" "1933.4" "2430.5" "2197.8" "1899.1" "4329.0" "" "" "" "" "" "" "" "" "" "" "2163.9" "1835.1" "1448.5" "1495.7" "2042.9" "1650.2" "2061.7" "1590.5" "1280.9" "4329.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985965989456980911" "False" "High" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0.000" "False" "141.818" "19" "27" "43" "27" "1508" "168.5" "6.62" "138.24" "27" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894, Pf21720" "25929" "ENSG00000082516" "GEMIN5" "Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "0.987" "0.938" "0.976" "1.022" "0.987" "0.973" "0.963" "0.965" "1.006" "1392.9" "1375.3" "1306.9" "1360.1" "1422.8" "1374.6" "1354.7" "1341.3" "1343.5" "1401.2" "" "" "" "" "" "" "" "" "" "" "1257.3" "1060.9" "1010.8" "915.9" "1186.9" "1173.2" "1149.2" "970.7" "906.2" "1401.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602445909866352508" "False" "High" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "0.000" "False" "141.507" "32" "26" "102" "26" "710" "76.6" "4.70" "288.48" "26" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Major pathway of rRNA processing in the nucleolus and cytosol; Respiratory syncytial virus (RSV) attachment and entry" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "4" "0" "1.012" "1.191" "0.974" "1.009" "1.147" "1.020" "0.998" "1.138" "1.142" "6099.2" "6171.1" "7263.6" "5941.7" "6155.0" "6995.4" "6224.1" "6084.0" "6942.9" "6967.8" "" "" "" "" "" "" "" "" "" "" "5505.6" "4760.0" "5617.9" "4001.1" "5134.3" "5970.7" "5279.8" "4402.9" "4682.9" "6967.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317219429199659424" "False" "High" "IsMasterProtein" "Q9H6Z4" "Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1" "0.000" "False" "140.572" "32" "15" "42" "15" "567" "60.2" "4.78" "146.45" "15" "transport" "nucleus;other cell component" "other molecular function" "Pf00638" "8498" "ENSG00000031823" "RANBP3" "B2RAT8; hsa:8498; O60405; O75759; O75760; Q9BT47; Q9H6Z4; Q9UG74" "" "" "0" "0" "1.017" "0.975" "0.975" "1.013" "0.986" "1.011" "1.010" "0.987" "0.713" "2252.7" "2291.0" "2196.4" "2195.5" "2282.7" "2220.8" "2278.3" "2275.0" "2222.7" "1606.0" "" "" "" "" "" "" "" "" "" "" "2033.5" "1767.1" "1698.8" "1478.4" "1904.1" "1895.4" "1932.6" "1646.4" "1499.2" "1606.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6534557055474382647" "False" "High" "IsMasterProtein" "P63267" "Actin, gamma-enteric smooth muscle OS=Homo sapiens OX=9606 GN=ACTG2 PE=1 SV=1" "0.000" "False" "139.248" "35" "12" "203" "3" "376" "41.9" "5.48" "603.61" "12" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "72" "ENSG00000163017" "ACTG2" "B2R7E7; B4E315; D6W5H8; E9PG30; hsa:72; P12718; P63267; Q504R1; Q6FI22" "Smooth Muscle Contraction" "Common pathways underlying drug addiction; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Pleural mesothelioma" "4" "0" "1.075" "1.027" "1.032" "1.064" "1.024" "1.053" "1.032" "1.055" "0.736" "1302.6" "1400.1" "1337.5" "1343.6" "1385.6" "1333.3" "1371.7" "1344.5" "1373.7" "959.2" "" "" "" "" "" "" "" "" "" "" "1175.8" "1080.0" "1034.5" "904.8" "1155.8" "1138.0" "1163.6" "973.0" "926.5" "959.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1511702505276588775" "False" "High" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "0.000" "False" "138.902" "33" "20" "66" "19" "704" "80.1" "8.21" "197.51" "20" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "Respiratory electron transport" "TNF-alpha signaling pathway; TGF-beta signaling pathway; Clock-controlled autophagy in bone metabolism" "4" "0" "1.015" "0.879" "0.981" "1.020" "0.876" "1.050" "1.011" "0.865" "0.685" "2729.5" "2769.9" "2399.5" "2678.2" "2783.7" "2391.2" "2865.3" "2760.2" "2361.8" "1869.3" "" "" "" "" "" "" "" "" "" "" "2463.8" "2136.5" "1855.8" "1803.5" "2322.1" "2041.0" "2430.6" "1997.6" "1593.0" "1869.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562319574892213792" "False" "High" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "0.000" "False" "138.713" "44" "12" "111" "12" "335" "36.0" "8.46" "346.54" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Glycolysis; Gluconeogenesis" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "16" "0" "1.031" "1.079" "1.047" "1.016" "1.105" "1.035" "1.032" "1.093" "0.727" "5613.2" "5788.0" "6054.8" "5874.9" "5703.1" "6201.6" "5808.1" "5792.8" "6134.1" "4081.4" "" "" "" "" "" "" "" "" "" "" "5066.9" "4464.5" "4683.0" "3956.1" "4757.3" "5293.1" "4926.9" "4192.2" "4137.4" "4081.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6496925005546959600" "False" "High" "IsMasterProtein" "Q13509" "Tubulin beta-3 chain OS=Homo sapiens OX=9606 GN=TUBB3 PE=1 SV=2" "0.000" "False" "138.674" "33" "12" "94" "2" "450" "50.4" "4.93" "230.80" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10381" "ENSG00000258947" "TUBB3" "A8K854; hsa:10381; Q13509; Q9BTZ0; Q9BW10" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Hedgehog 'off' state; Post-chaperonin tubulin folding pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Exercise-induced circadian regulation; Alzheimer's disease; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "38" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "361994698644895597" "False" "High" "IsMasterProtein" "P07355" "Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2" "0.000" "False" "138.108" "51" "16" "59" "16" "339" "38.6" "7.75" "190.66" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00191" "302" "ENSG00000182718" "ANXA2" "hsa:302; P07355; Q567R4; Q6N0B3; Q8TBV2; Q96DD5; Q9UDH8" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Smooth Muscle Contraction; Dissolution of Fibrin Clot" "Gastrin signaling pathway; CCL18 signaling pathway; Prostaglandin synthesis and regulation" "7" "0" "1.047" "1.106" "0.980" "1.042" "1.187" "1.019" "1.065" "1.120" "0.796" "2967.7" "3108.4" "3282.5" "2909.1" "3091.4" "3522.9" "3025.0" "3160.4" "3324.5" "2363.8" "" "" "" "" "" "" "" "" "" "" "2678.9" "2397.6" "2538.8" "1959.0" "2578.7" "3006.9" "2566.1" "2287.2" "2242.3" "2363.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262993958771163174" "False" "High" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "0.000" "False" "137.744" "50" "15" "65" "15" "338" "35.5" "8.68" "206.19" "15" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; O43682; P40926" "Gluconeogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; 7q11.23 distal copy number variation; TCA cycle (aka Krebs or citric acid cycle)" "10" "0" "1.004" "1.152" "0.995" "1.034" "1.144" "1.057" "1.025" "1.146" "0.659" "4327.7" "4347.1" "4984.3" "4307.0" "4474.6" "4951.2" "4574.9" "4437.3" "4958.0" "2853.7" "" "" "" "" "" "" "" "" "" "" "3906.5" "3353.1" "3855.1" "2900.4" "3732.6" "4225.9" "3880.8" "3211.2" "3344.1" "2853.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6576828257658518084" "False" "High" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "0.000" "False" "137.072" "49" "17" "130" "2" "449" "49.9" "5.10" "400.24" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "Recruitment of NuMA to mitotic centrosomes; MHC class II antigen presentation; HCMV Early Events; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intraflagellar transport; Recycling pathway of L1; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease; HDAC6 interactions in the central nervous system" "37" "15" "0.991" "0.916" "0.913" "1.034" "0.951" "0.950" "0.988" "0.954" "0.773" "6160.1" "6104.7" "5640.3" "5625.4" "6370.4" "5856.5" "5851.5" "6085.8" "5878.0" "4764.4" "" "" "" "" "" "" "" "" "" "" "5560.6" "4708.8" "4362.4" "3788.1" "5313.9" "4998.6" "4963.7" "4404.2" "3964.6" "4764.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5003304044033613110" "False" "High" "IsMasterProtein" "O43175" "D-3-phosphoglycerate dehydrogenase OS=Homo sapiens OX=9606 GN=PHGDH PE=1 SV=4" "0.000" "False" "136.964" "32" "14" "55" "14" "533" "56.6" "6.71" "188.57" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00389, Pf02826, Pf19304" "26227" "ENSG00000092621" "PHGDH" "B2RD08; hsa:26227; O43175; Q5SZU3; Q9BQ01" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "5" "0" "1.011" "0.652" "1.084" "0.986" "0.703" "1.030" "0.961" "0.699" "0.717" "3228.3" "3264.4" "2103.8" "3500.8" "3184.3" "2269.8" "3325.1" "3102.3" "2257.4" "2316.1" "" "" "" "" "" "" "" "" "" "" "2914.1" "2517.9" "1627.2" "2357.5" "2656.2" "1937.3" "2820.7" "2245.1" "1522.6" "2316.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "657128700828351651" "False" "High" "IsMasterProtein" "Q16643" "Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4" "0.000" "False" "136.528" "30" "14" "36" "14" "649" "71.4" "4.45" "135.95" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "1627" "ENSG00000113758" "DBN1" "A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOD GTPase cycle; RHOH GTPase cycle" "5q35 copy number variation" "5" "0" "1.007" "1.047" "0.921" "0.946" "0.951" "0.947" "0.965" "1.012" "0.855" "2295.7" "2311.2" "2403.2" "2114.8" "2172.1" "2182.5" "2174.4" "2216.1" "2323.7" "1962.7" "" "" "" "" "" "" "" "" "" "" "2072.3" "1782.7" "1858.7" "1424.1" "1811.9" "1862.8" "1844.5" "1603.8" "1567.3" "1962.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4595887854081889880" "False" "High" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "0.000" "False" "136.421" "26" "21" "54" "21" "953" "105.8" "5.39" "147.83" "21" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004, Pf21505" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Downstream TCR signaling; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Separation of Sister Chromatids; Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Somitogenesis; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC)" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.035" "0.808" "1.025" "1.042" "0.806" "0.981" "0.949" "0.833" "0.784" "2253.3" "2333.1" "1820.8" "2310.4" "2347.9" "1815.2" "2209.7" "2137.9" "1877.4" "1765.6" "" "" "" "" "" "" "" "" "" "" "2034.0" "1799.6" "1408.3" "1555.9" "1958.5" "1549.3" "1874.4" "1547.2" "1266.3" "1765.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5095696648215945885" "False" "High" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "0.000" "False" "136.311" "42" "13" "64" "10" "364" "39.4" "6.87" "248.07" "13" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "0" "1.060" "1.136" "0.922" "1.014" "1.173" "1.023" "1.024" "1.088" "0.731" "1590.7" "1685.6" "1807.3" "1466.9" "1613.1" "1865.6" "1627.9" "1629.2" "1730.9" "1162.1" "" "" "" "" "" "" "" "" "" "" "1435.9" "1300.2" "1397.9" "987.8" "1345.6" "1592.3" "1380.9" "1179.0" "1167.5" "1162.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2890284807861643792" "False" "High" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "0.000" "False" "135.569" "25" "23" "48" "23" "1010" "107.7" "6.70" "151.30" "23" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Purine ribonucleoside monophosphate biosynthesis" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "4" "0" "1.000" "0.711" "0.982" "0.947" "0.748" "1.007" "0.955" "0.673" "0.950" "2855.0" "2854.1" "2029.2" "2803.0" "2702.5" "2135.4" "2875.7" "2725.8" "1921.9" "2712.3" "" "" "" "" "" "" "" "" "" "" "2577.1" "2201.5" "1569.5" "1887.5" "2254.4" "1822.6" "2439.4" "1972.6" "1296.3" "2712.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4137218576109141814" "False" "High" "IsMasterProtein" "Q06210" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3" "0.000" "False" "135.433" "34" "20" "45" "20" "699" "78.8" "7.11" "142.92" "20" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "2673" "ENSG00000198380" "GFPT1" "hsa:2673; Q06210; Q53QE6; Q9BXF8" "XBP1(S) activates chaperone genes; Synthesis of UDP-N-acetyl-glucosamine; Defective GFPT1 causes CMSTA1" "UDP-derived sugars synthesis in fibroblasts" "4" "0" "1.000" "0.759" "1.030" "0.998" "0.772" "1.027" "1.028" "0.757" "0.777" "1930.2" "1930.9" "1465.4" "1987.3" "1926.3" "1489.3" "1983.2" "1984.8" "1461.2" "1500.2" "" "" "" "" "" "" "" "" "" "" "1742.3" "1489.4" "1133.4" "1338.3" "1606.8" "1271.2" "1682.3" "1436.4" "985.6" "1500.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973589334991488607" "False" "High" "IsMasterProtein" "Cont_P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "0.000" "True" "135.113" "30" "19" "42" "16" "644" "66.0" "8.12" "131.67" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Formation of the cornified envelope; Neutrophil degranulation" "Corticotropin-releasing hormone signaling pathway" "4" "3" "1.117" "1.853" "1.514" "0.657" "0.828" "0.699" "1.273" "0.818" "0.647" "2486.6" "2777.1" "4607.1" "3763.7" "1632.7" "2058.7" "1737.7" "3165.5" "2034.9" "1608.7" "" "" "" "" "" "" "" "" "" "" "2244.6" "2142.1" "3563.3" "2534.5" "1361.9" "1757.1" "1474.0" "2290.9" "1372.5" "1608.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4347150339173577721" "False" "High" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "0.000" "False" "134.844" "23" "32" "45" "32" "1312" "153.8" "6.89" "139.19" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "29" "0" "1.062" "0.914" "0.984" "1.104" "0.885" "1.121" "1.082" "0.923" "1.830" "2656.0" "2819.5" "2427.9" "2614.2" "2931.3" "2349.6" "2978.5" "2874.0" "2451.6" "4860.9" "" "" "" "" "" "" "" "" "" "" "2397.5" "2174.8" "1877.8" "1760.4" "2445.2" "2005.4" "2526.6" "2079.9" "1653.6" "4860.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737848688669361571" "False" "High" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "0.000" "False" "134.227" "48" "15" "35" "15" "370" "40.5" "5.10" "122.98" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "RHOH GTPase cycle" "Alstrom syndrome" "2" "0" "0.982" "0.986" "0.986" "0.987" "0.986" "0.998" "0.995" "0.973" "0.952" "1636.9" "1607.8" "1614.2" "1614.6" "1616.2" "1614.4" "1632.9" "1628.7" "1593.0" "1558.0" "" "" "" "" "" "" "" "" "" "" "1477.6" "1240.2" "1248.5" "1087.3" "1348.2" "1377.9" "1385.1" "1178.7" "1074.4" "1558.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4532618803689773049" "False" "High" "IsMasterProtein" "P00491" "Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2" "0.000" "False" "134.104" "49" "11" "50" "11" "289" "32.1" "6.95" "171.69" "11" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf01048" "4860" "ENSG00000198805; ENSG00000291814" "PNP" "B2R8S5; D3DS00; hsa:4860; P00491; Q15160; Q5PZ03" "Neutrophil degranulation; Purine catabolism; Ribavirin ADME; Purine salvage; Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine" "VEGFA-VEGFR2 signaling" "6" "0" "0.931" "1.152" "0.856" "0.903" "1.170" "0.883" "0.969" "0.954" "0.623" "1548.1" "1441.9" "1783.5" "1325.0" "1397.2" "1810.8" "1367.5" "1500.8" "1477.3" "964.7" "" "" "" "" "" "" "" "" "" "" "1397.4" "1112.2" "1379.4" "892.3" "1165.5" "1545.6" "1160.0" "1086.1" "996.4" "964.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6560846777174153588" "False" "High" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "0.000" "False" "134.102" "21" "24" "42" "24" "1224" "138.3" "7.66" "131.74" "24" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "0.977" "0.972" "1.025" "1.010" "1.019" "1.018" "0.995" "0.983" "0.981" "2226.1" "2175.2" "2163.0" "2281.9" "2249.0" "2267.5" "2266.9" "2215.6" "2188.7" "2184.0" "" "" "" "" "" "" "" "" "" "" "2009.4" "1677.8" "1672.9" "1536.6" "1876.0" "1935.3" "1923.0" "1603.4" "1476.2" "2184.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "623640857413414358" "False" "High" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "0.000" "False" "133.885" "58" "14" "106" "10" "247" "28.3" "4.89" "288.69" "14" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "22" "1" "0.973" "1.023" "0.951" "1.003" "1.045" "1.003" "1.022" "1.052" "0.762" "3981.7" "3874.4" "4072.7" "3786.1" "3995.0" "4160.5" "3991.7" "4069.1" "4187.7" "3035.8" "" "" "" "" "" "" "" "" "" "" "3594.1" "2988.5" "3150.0" "2549.6" "3332.5" "3551.0" "3386.1" "2944.7" "2824.6" "3035.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2527179580342077355" "False" "High" "IsMasterProtein" "Q9NUQ9" "CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1" "0.000" "False" "133.700" "45" "12" "62" "12" "324" "36.7" "6.06" "211.49" "12" "cell organization and biogenesis;other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07159" "51571" "ENSG00000153310" "CYRIB" "hsa:51571; Q96AZ5; Q9NUQ9; Q9NW21; Q9NZE7" "Platelet degranulation" "" "1" "0" "1.012" "1.057" "1.011" "1.054" "1.110" "1.005" "1.008" "1.130" "0.758" "2415.6" "2443.6" "2553.9" "2443.0" "2545.7" "2682.0" "2427.3" "2434.5" "2729.8" "1831.2" "" "" "" "" "" "" "" "" "" "" "2180.5" "1884.9" "1975.2" "1645.1" "2123.5" "2289.1" "2059.0" "1761.8" "1841.2" "1831.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6979633451004201219" "False" "High" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "0.000" "False" "133.679" "57" "11" "100" "6" "246" "28.1" "4.83" "278.73" "11" "signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "33" "2" "1.033" "1.009" "0.994" "0.991" "1.080" "0.993" "1.009" "1.034" "0.775" "1523.8" "1574.4" "1538.2" "1514.5" "1509.6" "1645.9" "1513.0" "1536.9" "1576.3" "1180.5" "" "" "" "" "" "" "" "" "" "" "1375.4" "1214.4" "1189.7" "1019.8" "1259.2" "1404.8" "1283.4" "1112.2" "1063.2" "1180.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752798674986433827" "False" "High" "IsMasterProtein" "Q5T4S7" "E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1" "0.000" "False" "133.418" "6" "29" "39" "29" "5183" "573.5" "6.04" "123.54" "29" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02207, Pf13764, Pf19423" "23352" "ENSG00000127481" "UBR4" "A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S7; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "" "2" "0" "1.015" "0.809" "0.994" "0.983" "0.762" "1.007" "0.985" "0.800" "1.191" "1756.1" "1783.0" "1419.9" "1744.8" "1726.8" "1338.4" "1768.9" "1730.4" "1405.0" "2091.8" "" "" "" "" "" "" "" "" "" "" "1585.2" "1375.3" "1098.2" "1174.9" "1440.4" "1142.3" "1500.5" "1252.3" "947.6" "2091.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630001761870027344" "False" "High" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "0.000" "False" "132.648" "40" "18" "53" "17" "504" "56.0" "8.53" "152.62" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "RHOG GTPase cycle; Mitochondrial protein degradation; Metabolism of folate and pterines" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders" "13" "1" "1.008" "1.095" "1.017" "1.067" "1.141" "1.027" "1.056" "1.154" "0.659" "1927.9" "1943.7" "2110.6" "1959.9" "2057.2" "2199.4" "1980.5" "2035.4" "2224.4" "1270.4" "" "" "" "" "" "" "" "" "" "" "1740.3" "1499.3" "1632.5" "1319.8" "1716.0" "1877.2" "1680.0" "1473.0" "1500.3" "1270.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1936662048644361405" "False" "High" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "0.000" "False" "132.563" "24" "23" "47" "23" "971" "110.3" "5.77" "142.57" "23" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "0.975" "0.798" "1.023" "0.996" "0.843" "1.002" "0.938" "0.864" "1.523" "2377.3" "2318.5" "1896.5" "2431.2" "2367.9" "2004.3" "2381.3" "2229.2" "2054.3" "3620.1" "" "" "" "" "" "" "" "" "" "" "2145.9" "1788.4" "1466.8" "1637.2" "1975.2" "1710.7" "2020.0" "1613.3" "1385.6" "3620.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929162783006905550" "False" "High" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "0.000" "False" "132.016" "51" "17" "47" "17" "333" "38.4" "5.80" "165.10" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "16" "0" "1.070" "0.925" "1.001" "0.985" "0.962" "0.981" "0.966" "0.900" "0.732" "3021.7" "3233.3" "2795.6" "3026.2" "2977.2" "2907.0" "2963.9" "2919.0" "2719.7" "2212.5" "" "" "" "" "" "" "" "" "" "" "2727.6" "2494.0" "2162.2" "2037.9" "2483.5" "2481.1" "2514.2" "2112.4" "1834.4" "2212.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3988620745573507049" "False" "High" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "0.000" "False" "131.013" "27" "24" "50" "24" "919" "103.2" "5.72" "154.08" "24" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.020" "1.041" "1.004" "1.000" "1.098" "0.968" "0.973" "1.093" "0.800" "3405.6" "3473.4" "3545.2" "3418.0" "3405.8" "3740.3" "3295.7" "3312.1" "3722.7" "2724.3" "" "" "" "" "" "" "" "" "" "" "3074.1" "2679.2" "2742.0" "2301.7" "2841.0" "3192.4" "2795.7" "2397.0" "2510.9" "2724.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "627927697280554035" "False" "High" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "0.000" "False" "130.112" "24" "28" "42" "27" "1220" "138.7" "5.49" "121.37" "28" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf11987, Pf14578" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; Ciliary landscape" "3" "1" "1.024" "1.181" "1.017" "0.949" "1.138" "0.977" "0.879" "1.161" "0.945" "2468.1" "2528.0" "2915.3" "2510.0" "2341.1" "2808.8" "2410.9" "2170.5" "2865.9" "2331.8" "" "" "" "" "" "" "" "" "" "" "2227.9" "1949.9" "2254.8" "1690.2" "1952.8" "2397.3" "2045.1" "1570.8" "1933.0" "2331.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418914028943411131" "False" "High" "IsMasterProtein" "P29144" "Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4" "0.000" "False" "129.841" "22" "26" "42" "26" "1249" "138.3" "6.32" "122.90" "26" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00082, Pf12580, Pf12583, Pf21223, Pf21316" "7174" "ENSG00000134900" "TPP2" "hsa:7174; P29144; Q5VZU8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.017" "1.016" "1.000" "0.997" "1.051" "1.015" "1.021" "1.014" "0.743" "2562.7" "2606.8" "2603.6" "2563.4" "2554.3" "2693.7" "2600.6" "2615.9" "2599.5" "1905.2" "" "" "" "" "" "" "" "" "" "" "2313.3" "2010.7" "2013.7" "1726.2" "2130.7" "2299.1" "2206.0" "1893.1" "1753.4" "1905.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546682892855641805" "False" "High" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "0.000" "False" "129.674" "33" "15" "35" "13" "514" "55.8" "6.90" "127.39" "15" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Potential therapeutics for SARS; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "Rett syndrome" "5" "1" "1.028" "0.686" "1.016" "1.021" "0.739" "1.042" "1.018" "0.757" "0.518" "2025.5" "2082.4" "1389.4" "2057.1" "2068.1" "1496.2" "2110.9" "2062.9" "1532.6" "1049.8" "" "" "" "" "" "" "" "" "" "" "1828.4" "1606.3" "1074.6" "1385.2" "1725.2" "1277.0" "1790.7" "1492.9" "1033.7" "1049.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8375301801822560127" "False" "High" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "0.000" "False" "129.484" "21" "18" "39" "18" "959" "106.4" "6.39" "126.03" "18" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "Mitochondrial protein degradation" "" "1" "0" "1.007" "0.921" "0.983" "1.042" "0.915" "1.001" "0.955" "0.899" "0.701" "2371.0" "2388.6" "2182.9" "2330.3" "2471.2" "2169.7" "2373.2" "2263.2" "2132.2" "1661.3" "" "" "" "" "" "" "" "" "" "" "2140.3" "1842.4" "1688.4" "1569.2" "2061.4" "1851.9" "2013.2" "1637.8" "1438.2" "1661.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707926075363841764" "False" "High" "IsMasterProtein" "Q99798" "Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2" "0.000" "False" "129.258" "26" "18" "34" "18" "780" "85.4" "7.61" "110.17" "18" "other metabolic processes;stress response;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00330, Pf00694" "50" "ENSG00000100412" "ACO2" "hsa:50; O75809; Q5JZ41; Q6FHX0; Q8TAQ6; Q99798" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.963" "0.795" "0.994" "1.006" "0.801" "1.011" "0.925" "0.861" "0.962" "1455.2" "1401.4" "1156.6" "1446.7" "1464.1" "1165.6" "1471.1" "1345.5" "1253.2" "1400.6" "" "" "" "" "" "" "" "" "" "" "1313.6" "1081.0" "894.6" "974.2" "1221.3" "994.9" "1247.9" "973.7" "845.3" "1400.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2064522308959827201" "False" "High" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "0.000" "False" "128.907" "31" "20" "37" "14" "729" "80.2" "8.27" "117.56" "20" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "SUMOylation of transcription cofactors" "Novel intracellular components of RIG-I-like receptor pathway" "2" "5" "1.044" "0.893" "0.951" "1.028" "0.969" "0.947" "0.914" "0.942" "1.228" "1556.4" "1625.1" "1389.7" "1480.0" "1600.3" "1508.9" "1474.5" "1422.4" "1466.5" "1911.1" "" "" "" "" "" "" "" "" "" "" "1404.9" "1253.5" "1074.9" "996.6" "1334.9" "1287.8" "1250.8" "1029.4" "989.1" "1911.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828229649447777005" "False" "High" "IsMasterProtein" "P31153" "S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1" "0.000" "False" "128.895" "44" "15" "56" "15" "395" "43.6" "6.48" "184.09" "15" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00438, Pf02772, Pf02773" "4144" "ENSG00000168906" "MAT2A" "A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5" "Methylation" "Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways" "5" "0" "0.952" "0.954" "0.923" "0.982" "0.901" "0.990" "1.028" "0.928" "0.736" "3533.5" "3363.3" "3370.8" "3261.9" "3469.4" "3182.8" "3498.1" "3630.7" "3279.2" "2601.2" "" "" "" "" "" "" "" "" "" "" "3189.6" "2594.2" "2607.1" "2196.6" "2894.0" "2716.6" "2967.4" "2627.5" "2211.8" "2601.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4155367153969888648" "False" "High" "IsMasterProtein" "Cont_P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "0.000" "True" "128.819" "41" "21" "37" "18" "584" "58.8" "5.21" "118.67" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "Formation of the cornified envelope" "" "2" "3" "1.360" "2.529" "1.505" "0.718" "1.426" "0.908" "1.724" "0.822" "0.678" "2327.0" "3164.8" "5884.8" "3502.2" "1669.7" "3318.3" "2113.9" "4011.9" "1912.7" "1578.1" "" "" "" "" "" "" "" "" "" "" "2100.5" "2441.2" "4551.5" "2358.4" "1392.8" "2832.2" "1793.2" "2903.4" "1290.1" "1578.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379954125319751521" "False" "High" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "0.000" "False" "127.940" "33" "19" "61" "18" "541" "59.6" "5.66" "188.43" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "0.967" "1.005" "0.978" "0.964" "1.006" "0.986" "0.976" "0.985" "0.712" "3850.6" "3723.3" "3871.2" "3765.7" "3712.2" "3873.8" "3795.7" "3759.6" "3791.4" "2742.7" "" "" "" "" "" "" "" "" "" "" "3475.8" "2872.0" "2994.2" "2535.8" "3096.6" "3306.3" "3219.8" "2720.8" "2557.3" "2742.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8282495750123490209" "False" "High" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "0.000" "False" "127.013" "32" "19" "56" "15" "644" "67.5" "7.61" "186.75" "19" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "1" "1.001" "1.048" "1.010" "1.017" "1.085" "1.013" "1.047" "1.032" "0.679" "3119.1" "3123.0" "3267.9" "3151.1" "3172.4" "3383.8" "3161.0" "3264.8" "3219.9" "2117.3" "" "" "" "" "" "" "" "" "" "" "2815.6" "2408.9" "2527.5" "2122.0" "2646.3" "2888.1" "2681.4" "2362.7" "2171.8" "2117.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649453304125061400" "False" "High" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "0.000" "False" "126.938" "21" "15" "38" "13" "894" "95.3" "8.76" "124.29" "15" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528, Pf20965" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "PKR-mediated signaling; Regulation of CDH11 gene transcription" "" "2" "2" "1.055" "1.234" "1.007" "1.061" "1.304" "0.995" "0.973" "1.234" "0.906" "1353.6" "1428.6" "1670.9" "1363.4" "1435.9" "1765.3" "1346.7" "1316.9" "1670.3" "1226.5" "" "" "" "" "" "" "" "" "" "" "1221.9" "1101.9" "1292.3" "918.1" "1197.8" "1506.7" "1142.4" "953.0" "1126.6" "1226.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-160533791377362281" "False" "High" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "0.000" "False" "126.932" "35" "11" "86" "10" "334" "36.6" "6.05" "272.50" "11" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Pyruvate metabolism" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "0" "1.001" "1.036" "1.014" "1.027" "1.131" "1.032" "1.044" "1.089" "0.771" "4820.1" "4825.8" "4991.9" "4885.7" "4949.8" "5453.8" "4974.2" "5032.1" "5250.5" "3715.1" "" "" "" "" "" "" "" "" "" "" "4351.0" "3722.4" "3860.9" "3290.0" "4128.9" "4654.9" "4219.5" "3641.7" "3541.4" "3715.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2050551167936510610" "False" "High" "IsMasterProtein" "Q01813" "ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2" "0.000" "False" "126.797" "34" "22" "38" "18" "784" "85.5" "7.55" "125.57" "22" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5214" "ENSG00000067057" "PFKP" "B3KS15; hsa:5214; Q01813; Q5VSR7; Q5VSR8" "Glycolysis" "Cori cycle; Clear cell renal cell carcinoma pathways; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "4" "1.072" "1.027" "1.060" "1.038" "1.041" "1.026" "0.976" "1.034" "0.714" "1457.3" "1561.8" "1496.0" "1545.2" "1513.2" "1517.5" "1494.5" "1422.3" "1507.5" "1040.6" "" "" "" "" "" "" "" "" "" "" "1315.5" "1204.7" "1157.1" "1040.6" "1262.3" "1295.2" "1267.7" "1029.3" "1016.8" "1040.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773459124454051332" "False" "High" "IsMasterProtein" "P49915" "GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1" "0.000" "False" "126.622" "28" "19" "35" "19" "693" "76.7" "6.87" "125.12" "19" "other metabolic processes" "cytosol" "other molecular function" "Pf00117, Pf00958, Pf02540" "8833" "ENSG00000163655" "GMPS" "A8K639; B4DXV7; F8W720; hsa:8833; P49915" "Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "" "2" "0" "0.974" "0.894" "0.957" "0.971" "0.892" "0.949" "0.979" "0.885" "0.964" "3127.5" "3047.6" "2797.2" "2993.8" "3037.9" "2790.4" "2967.4" "3061.7" "2767.7" "3013.9" "" "" "" "" "" "" "" "" "" "" "2823.1" "2350.7" "2163.5" "2016.1" "2534.1" "2381.7" "2517.1" "2215.8" "1866.8" "3013.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459324364456559330" "False" "High" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "0.000" "False" "125.319" "16" "26" "44" "25" "1599" "175.4" "5.33" "119.95" "26" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "20" "0" "0.927" "1.090" "0.965" "0.905" "0.995" "0.960" "0.803" "0.983" "3.054" "2440.4" "2262.0" "2660.1" "2354.8" "2207.9" "2427.8" "2342.1" "1960.2" "2397.9" "7454.1" "" "" "" "" "" "" "" "" "" "" "2202.9" "1744.8" "2057.4" "1585.7" "1841.8" "2072.1" "1986.7" "1418.6" "1617.3" "7454.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770447616449315305" "False" "High" "IsMasterProtein" "Q9Y678" "Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1" "0.000" "False" "124.729" "22" "17" "34" "16" "874" "97.7" "5.47" "118.56" "17" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01602, Pf08752, Pf16381" "22820" "ENSG00000181789" "COPG1" "A8K6M8; B3KMF6; hsa:22820; Q54AC4; Q9Y678" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "VEGFA-VEGFR2 signaling" "3" "1" "0.999" "0.875" "0.952" "1.002" "0.885" "0.995" "0.925" "0.853" "0.869" "1903.8" "1901.1" "1666.4" "1813.3" "1907.0" "1685.7" "1895.1" "1761.6" "1623.4" "1654.9" "" "" "" "" "" "" "" "" "" "" "1718.5" "1466.4" "1288.9" "1221.1" "1590.8" "1438.7" "1607.6" "1274.8" "1094.9" "1654.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1518063030880020019" "False" "High" "IsMasterProtein" "P12814" "Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2" "0.000" "False" "124.573" "25" "20" "47" "10" "892" "103.0" "5.41" "144.64" "20" "cell adhesion;cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "87" "ENSG00000072110" "ACTN1" "B3V8S3; B4DHH3; B7TY16; hsa:87; P12814; Q1HE25; Q9BTN1" "RHOD GTPase cycle; RHOF GTPase cycle; Platelet degranulation ; Nephrin family interactions; Syndecan interactions; RHOBTB2 GTPase cycle; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Ebola virus infection in host; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Regulation of actin cytoskeleton" "12" "0" "0.999" "1.034" "1.120" "0.994" "1.022" "0.995" "1.009" "1.129" "0.763" "517.7" "517.2" "535.3" "579.8" "514.4" "528.9" "515.2" "522.2" "584.5" "394.9" "" "" "" "" "" "" "" "" "" "" "467.4" "399.0" "414.0" "390.5" "429.1" "451.4" "437.0" "377.9" "394.2" "394.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5372925708799750934" "False" "High" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "0.000" "False" "124.049" "29" "17" "51" "17" "597" "68.0" "6.35" "165.51" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "" "3" "0" "0.998" "0.867" "1.003" "1.009" "0.910" "1.035" "1.020" "0.881" "1.227" "2038.1" "2035.0" "1767.8" "2045.2" "2057.4" "1854.3" "2108.4" "2077.8" "1795.0" "2500.8" "" "" "" "" "" "" "" "" "" "" "1839.7" "1569.7" "1367.3" "1377.2" "1716.2" "1582.6" "1788.5" "1503.7" "1210.7" "2500.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5232006824815591416" "False" "High" "IsMasterProtein" "P14317" "Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3" "0.000" "False" "122.606" "31" "13" "50" "13" "486" "54.0" "4.81" "178.11" "13" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02218" "3059" "ENSG00000180353" "HCLS1" "B4DQ69; hsa:3059; P14317; Q53Y93; Q6IBK9; Q9UDK0" "" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; TYROBP causal network in microglia" "3" "0" "0.985" "0.946" "0.981" "0.997" "0.935" "1.006" "1.067" "0.942" "0.700" "3392.3" "3340.6" "3209.4" "3329.4" "3380.4" "3172.1" "3412.3" "3620.5" "3194.0" "2376.3" "" "" "" "" "" "" "" "" "" "" "3062.1" "2576.8" "2482.2" "2242.0" "2819.8" "2707.4" "2894.6" "2620.1" "2154.3" "2376.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8957423501143175457" "False" "High" "IsMasterProtein" "Cont_P81948" "Tubulin alpha-4A chain OS=Bos taurus OX=9913 GN=TUBA4A PE=1 SV=2" "0.000" "True" "122.502" "45" "16" "77" "5" "448" "49.9" "5.06" "232.85" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100151951; 100302357; 100354352; 100400294; 100449357; 100734500; 100767686; 100995882; 101006121; 101095277; 101148853; 101379814; 101569770; 101606396; 101677236; 101838478; 101926805; 101969889; 102012828; 102177846; 102532857; 102746509; 102841369; 102928867; 102962068; 103007004; 103072784; 103110543; 103217904; 103261248; 103662744; 103727749; 104660054; 105064041; 105481257; 105504700; 105528059; 105587029; 105808789; 105857673; 105996598; 107138719; 107516732; 109265033; 109571050; 22145; 316531; 470654; 478918; 702583; 7277; 777775" "ENSANAG00000028048; ENSBIXG00005021445; ENSBMSG00010001061; ENSBTAG00000030974; ENSCAFG00000015209; ENSCAFG00020027000; ENSCAFG00030011006; ENSCAFG00845029842; ENSCANG00000024607; ENSCATG00000033332; ENSCGRG00001024425; ENSCHIG00000002435; ENSCJAG00000070762; ENSCLAG00000011603; ENSCPOG00000037151; ENSCSAG00000008100; ENSFCAG00000038881; ENSG00000127824; ENSGGOG00000023578; ENSJJAG00000011005; ENSLCNG00005009789; ENSMFAG00000007541; ENSMICG00000035827; ENSMLEG00000029671; ENSMMMG00000020450; ENSMMSG00000019327; ENSMMUG00000019628; ENSMNEG00000039170; ENSMSIG00000018170; ENSMUSG00000026202; ENSNGAG00000020443; ENSNLEG00000027445; ENSOARG00000020020; ENSOCUG00000026994; ENSPANG00000041659; ENSPCOG00000023925; ENSPEMG00000029240; ENSPLOG00000016209; ENSPPAG00000011142; ENSPPYG00000013203; ENSPSMG00000025346; ENSPSNG00000018656; ENSPTEG00000039375; ENSPTIG00000021758; ENSPTRG00000012949; ENSRNOG00000003597; ENSRNOG00055010434; ENSRNOG00060007884; ENSRNOG00065008885; ENSRROG00000044949; ENSSSCG00000016216; ENSSSCG00025016272; ENSSSCG00035020742; ENSSSCG00040017674; ENSSSCG00050039745; ENSSSCG00070016481; ENSSTOG00000019497; ENSSVLG00005016017; ENSTGEG00000012532; ENSTSYG00000011750; ENSUMAG00000018763; ENSUPAG00010012836; ENSVVUG00000025771" "LOC101334183; LOC102532857; LOC102746509; LOC103662744; LOC106970047; LOC109265033; LOC111143142; LOC111171848; LOC112411846; LOC112838391; LOC112872268; LOC112922524; LOC113920876; LOC114495658; LOC118898366; Tuba4a; TUBA4A" "A0A0D9R6X5; A0A1S2ZI83; A0A1S3GBQ2; A0A1U7Q653; A0A1U7TVH0; A0A286ZNY1; A0A2I2UZ20; A0A2I2YM80; A0A2J8NG28; A0A2J8TUH3; A0A2K5DHU1; A0A2K5HTH7; A0A2K5M1H8; A0A2K5Y6I3; A0A2K6D749; A0A2K6GBF8; A0A2K6RS93; A0A2R8ZC21; A0A2U3W3Z0; A0A2U3YH71; A0A2Y9IV09; A0A2Y9N2F1; A0A340WE79; A0A341CW34; A0A384AKZ1; A0A384C1E6; A0A3Q7QMN7; A0A3Q7SCG6; A0A452DNE3; A0A484GTP9; A0A485MVS4; A0A4W2GGR2; A0A4X1UG19; A0A5N3WUA1; A0A663D8Z2; A0A667GI79; A0A6D2XJT6; A0A6I9I9T5; A0A6I9L693; A0A6J1YN80; A0A6J2LL95; A0A6J3RLQ7; A0A6P3CX09; A0A6P3FIC2; A0A6P5D399; A0A6P6ISG9; A0A6P9F8Q5; A0A7J8JNJ1; A0A811ZBS6; A0A8B7EMV4; A0A8B7KBC2; A0A8B8XXA4; A0A8C0LT90; A0A8C0MZ87; A0A8C2N284; A0A8C2VS48; A0A8C5KB95; A0A8C6E681; A0A8C6EXI3; A0A8C6HJF8; A0A8C6RPC4; A0A8C8XN00; A0A8C9ASB4; A0A8C9CIF4; A0A8C9IX37; A0A8C9KT44; A0A8D2D621; A0A8D2K0Z6; A0A8D2KIE8; A0A8I3Q1H9; A0A8I5NZD6; A0A8U0N0J8; A0A9B0TPY2; A0A9V1FEX0; A0A9W3GNM5; A6JVZ9; A8MUB1; aju:106970047; B3KNQ6; biu:109571050; bta:777775; C5ISA2; caty:105587029; cfr:102522237; chx:102177846; cjc:100400294; cpoc:100734500; csyr:103261248; dle:111171848; dord:105996598; elk:111143142; F6QRE8; F7HZP3; fca:101095277; G1RDQ0; G1TR82; H0V3I8; H2P8P0; H2QJG6; hsa:7277; I3NHW3; K9IKB3; lww:102746509; maua:101838478; mcf:101926805; mmu:22145; mmur:105857673; mpuf:101677236; nasi:112411846; ngi:103727749; oas:100302357; ocu:100354352; oro:101379814; P05215; P68366; P68367; P68368; P81948; panu:101006121; pcoo:112872268; pdic:114495658; pon:100449357; pps:100995882; ptg:102962068; Q17QT1; Q3TY31; Q5E986; Q5XIF6; ray:107516732; rno:316531; rro:104660054; ssc:100151951; umr:103662744; vpc:102532857; vvp:112922524" "Platelet degranulation ; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Intraflagellar transport; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; PKR-mediated signaling; Recycling pathway of L1; MHC class II antigen presentation; RHO GTPases activate IQGAPs; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Platelet degranulation ; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state; Platelet degranulation ; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Platelet degranulation ; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; RHO GTPases Activate Formins; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Kinesins; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Kinesins; PKR-mediated signaling; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Hedgehog 'off' state; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sealing of the nuclear envelope (NE) by ESCRT-III; Aggrephagy; Recycling pathway of L1; RHO GTPases activate IQGAPs; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; HDAC6 interactions in the central nervous system" "160" "0" "1.062" "0.940" "1.024" "1.018" "0.892" "1.016" "1.004" "0.928" "0.774" "490.7" "521.1" "461.1" "502.7" "499.8" "437.7" "498.6" "492.5" "455.5" "379.6" "" "" "" "" "" "" "" "" "" "" "442.9" "402.0" "356.6" "338.5" "416.9" "373.6" "422.9" "356.4" "307.2" "379.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418505594273786343" "False" "High" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "0.000" "False" "122.257" "29" "12" "45" "11" "452" "50.9" "8.69" "161.60" "12" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "7" "1" "1.030" "0.782" "0.968" "0.971" "0.816" "0.992" "0.999" "0.814" "0.744" "2636.3" "2715.1" "2060.7" "2551.1" "2560.5" "2149.9" "2614.4" "2632.4" "2146.3" "1962.2" "" "" "" "" "" "" "" "" "" "" "2379.7" "2094.3" "1593.8" "1717.9" "2135.8" "1835.0" "2217.7" "1905.1" "1447.6" "1962.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726683976815450871" "False" "High" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "0.000" "False" "121.319" "42" "14" "88" "13" "332" "36.7" "8.27" "297.83" "14" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Pyruvate metabolism" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders" "20" "1" "1.016" "1.132" "1.014" "0.994" "1.192" "1.032" "1.060" "1.114" "0.760" "5427.4" "5516.5" "6143.3" "5501.7" "5393.7" "6469.1" "5602.4" "5751.8" "6047.3" "4126.8" "" "" "" "" "" "" "" "" "" "" "4899.2" "4255.2" "4751.4" "3704.8" "4499.2" "5521.4" "4752.4" "4162.5" "4078.8" "4126.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543503445909431130" "False" "High" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "0.000" "False" "121.319" "25" "15" "44" "15" "732" "81.2" "5.48" "157.16" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "Neutrophil degranulation; Eukaryotic Translation Termination" "" "2" "0" "1.029" "1.046" "1.043" "1.015" "1.062" "1.016" "0.996" "1.105" "0.711" "2098.9" "2160.8" "2194.5" "2189.4" "2130.4" "2229.5" "2133.3" "2090.4" "2318.3" "1492.9" "" "" "" "" "" "" "" "" "" "" "1894.7" "1666.7" "1697.3" "1474.3" "1777.1" "1902.9" "1809.6" "1512.8" "1563.7" "1492.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3353104297975983136" "False" "High" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "0.000" "False" "121.023" "35" "18" "37" "18" "534" "60.9" "8.44" "122.25" "18" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "0.987" "0.772" "0.989" "1.037" "0.825" "0.990" "0.991" "0.807" "0.917" "2683.1" "2649.6" "2072.5" "2654.2" "2783.4" "2214.7" "2657.2" "2659.0" "2164.1" "2459.1" "" "" "" "" "" "" "" "" "" "" "2422.0" "2043.7" "1603.0" "1787.3" "2321.8" "1890.2" "2254.1" "1924.3" "1459.6" "2459.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1343514979661683430" "False" "High" "IsMasterProtein" "P22234" "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "0.000" "False" "120.924" "35" "14" "53" "14" "425" "47.0" "7.23" "172.50" "14" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Purine ribonucleoside monophosphate biosynthesis" "Metabolic reprogramming in colon cancer" "2" "0" "0.961" "0.941" "1.009" "1.053" "0.971" "1.008" "0.997" "0.925" "0.743" "2918.2" "2803.5" "2746.8" "2943.4" "3072.1" "2832.6" "2942.8" "2910.8" "2700.7" "2168.1" "" "" "" "" "" "" "" "" "" "" "2634.2" "2162.5" "2124.5" "1982.1" "2562.6" "2417.7" "2496.3" "2106.5" "1821.6" "2168.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535556334998408323" "False" "High" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=3" "0.000" "False" "120.923" "38" "16" "48" "16" "455" "49.8" "7.61" "164.08" "16" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "7284" "ENSG00000178952" "TUFM" "hsa:7284; O15276; P49411" "Mitochondrial translation elongation; SARS-CoV-2 modulates autophagy" "16p11.2 distal deletion syndrome" "3" "0" "1.011" "0.850" "0.979" "0.991" "0.859" "0.992" "0.987" "0.912" "0.881" "3055.9" "3088.8" "2596.8" "2990.9" "3027.0" "2624.3" "3032.1" "3015.0" "2787.9" "2693.1" "" "" "" "" "" "" "" "" "" "" "2758.4" "2382.5" "2008.4" "2014.1" "2525.0" "2239.9" "2572.1" "2181.9" "1880.4" "2693.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4943408873611006946" "False" "High" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "0.000" "False" "120.801" "46" "20" "56" "20" "459" "51.8" "5.43" "166.52" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Estrogen-dependent gene expression; Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Attenuation phase" "Androgen receptor signaling pathway" "6" "0" "0.989" "0.879" "0.942" "0.961" "0.815" "0.998" "0.890" "0.817" "1.414" "3006.9" "2972.7" "2641.8" "2832.6" "2889.7" "2450.4" "2999.5" "2675.4" "2456.8" "4250.7" "" "" "" "" "" "" "" "" "" "" "2714.2" "2293.0" "2043.2" "1907.5" "2410.5" "2091.4" "2544.4" "1936.2" "1657.1" "4250.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5903683586191117105" "False" "High" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "0.000" "False" "120.429" "20" "17" "45" "17" "908" "100.1" "5.20" "140.44" "17" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "65" "0" "0.978" "0.735" "1.000" "1.023" "0.791" "0.959" "0.988" "0.790" "0.877" "2635.4" "2576.3" "1936.8" "2634.1" "2695.4" "2085.4" "2527.7" "2602.9" "2081.5" "2310.6" "" "" "" "" "" "" "" "" "" "" "2378.9" "1987.2" "1498.0" "1773.8" "2248.4" "1779.9" "2144.2" "1883.7" "1403.9" "2310.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382790352375516909" "False" "High" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "0.000" "False" "119.497" "17" "19" "42" "19" "1217" "135.5" "5.26" "130.87" "19" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "0.990" "0.948" "1.059" "1.037" "0.938" "0.999" "0.968" "0.983" "0.849" "2100.8" "2079.7" "1991.3" "2224.6" "2178.5" "1970.6" "2098.3" "2033.4" "2065.3" "1782.6" "" "" "" "" "" "" "" "" "" "" "1896.3" "1604.2" "1540.1" "1498.0" "1817.2" "1681.9" "1780.0" "1471.6" "1393.0" "1782.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630142415015692295" "False" "High" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "0.000" "False" "119.165" "25" "11" "47" "11" "528" "59.4" "4.41" "153.36" "11" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "" "7" "0" "1.094" "1.107" "1.031" "1.060" "1.128" "1.016" "1.046" "1.104" "0.791" "2229.2" "2439.5" "2466.6" "2298.7" "2364.0" "2514.2" "2265.7" "2332.5" "2461.3" "1762.9" "" "" "" "" "" "" "" "" "" "" "2012.2" "1881.7" "1907.8" "1547.9" "1972.0" "2145.9" "1922.0" "1688.0" "1660.1" "1762.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129667850847229200" "False" "High" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "0.000" "False" "118.425" "33" "14" "48" "14" "483" "53.1" "7.23" "157.60" "14" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "7" "0" "0.997" "0.815" "1.019" "0.951" "0.803" "1.012" "1.005" "0.810" "0.762" "3125.5" "3115.9" "2548.0" "3183.5" "2971.4" "2508.5" "3163.6" "3141.2" "2532.3" "2383.0" "" "" "" "" "" "" "" "" "" "" "2821.3" "2403.4" "1970.7" "2143.7" "2478.6" "2141.0" "2683.7" "2273.3" "1708.0" "2383.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6210925912035566058" "False" "High" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "0.000" "False" "117.532" "11" "21" "30" "21" "2115" "238.1" "5.78" "104.40" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21670" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "5" "0" "1.045" "1.447" "1.079" "1.033" "1.500" "1.014" "0.845" "1.453" "2.558" "928.1" "969.9" "1342.8" "1001.2" "958.6" "1392.5" "940.7" "784.5" "1348.6" "2374.2" "" "" "" "" "" "" "" "" "" "" "837.7" "748.2" "1038.6" "674.2" "799.6" "1188.6" "798.0" "567.7" "909.6" "2374.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5794386193398091018" "False" "High" "IsMasterProtein" "Q9NY33" "Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2" "0.000" "False" "117.279" "29" "18" "38" "18" "737" "82.5" "5.10" "124.19" "18" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03571" "10072" "ENSG00000254986" "DPP3" "B2RDB5; B4DLX4; F5H8L6; hsa:10072; O95748; Q969H2; Q9BV67; Q9HAL6; Q9NY33" "Neddylation; KEAP1-NFE2L2 pathway" "" "2" "0" "0.984" "1.032" "1.022" "0.995" "1.007" "0.958" "1.007" "1.029" "0.800" "1451.4" "1428.0" "1498.2" "1482.6" "1444.8" "1462.0" "1390.1" "1461.3" "1494.0" "1161.1" "" "" "" "" "" "" "" "" "" "" "1310.1" "1101.4" "1158.8" "998.4" "1205.2" "1247.9" "1179.2" "1057.5" "1007.7" "1161.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8579706144891720478" "False" "High" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "0.000" "False" "117.125" "24" "18" "31" "18" "1087" "120.9" "5.06" "108.23" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "20" "0" "1.062" "1.003" "1.046" "1.068" "0.975" "1.100" "1.078" "1.084" "1.345" "619.2" "657.5" "621.2" "647.4" "661.2" "603.9" "680.9" "667.4" "671.0" "833.1" "" "" "" "" "" "" "" "" "" "" "558.9" "507.1" "480.4" "436.0" "551.5" "515.5" "577.6" "483.0" "452.6" "833.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2158743068394578481" "False" "High" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "0.000" "False" "116.944" "25" "13" "39" "13" "623" "67.8" "7.66" "141.28" "13" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "7" "0" "1.050" "1.111" "1.014" "1.075" "1.170" "1.040" "1.018" "1.152" "0.757" "1868.9" "1962.8" "2075.6" "1894.8" "2008.4" "2186.7" "1944.1" "1903.1" "2152.9" "1415.4" "" "" "" "" "" "" "" "" "" "" "1687.0" "1514.0" "1605.4" "1276.0" "1675.3" "1866.3" "1649.1" "1377.3" "1452.1" "1415.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8610404900026586522" "False" "High" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "0.000" "False" "116.703" "34" "15" "72" "15" "417" "48.1" "4.44" "208.65" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "13" "0" "1.016" "1.133" "1.013" "1.120" "1.156" "1.073" "1.056" "1.146" "1.598" "3693.1" "3751.5" "4182.6" "3742.1" "4136.0" "4268.4" "3961.4" "3899.7" "4232.6" "5900.4" "" "" "" "" "" "" "" "" "" "" "3333.7" "2893.7" "3235.0" "2519.9" "3450.1" "3643.1" "3360.4" "2822.2" "2854.9" "5900.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-824304309308168891" "False" "High" "IsMasterProtein" "Q14005" "Pro-interleukin-16 OS=Homo sapiens OX=9606 GN=IL16 PE=1 SV=4" "0.000" "False" "116.387" "19" "19" "38" "19" "1332" "141.7" "8.06" "124.67" "19" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00595" "3603" "ENSG00000172349" "IL16" "A6NM20; A8MU65; B5TY35; B9EGR6; H3BVH5; hsa:3603; Q14005; Q16435; Q6VVE6; Q6ZMQ7; Q9UP18" "Other interleukin signaling" "" "1" "0" "0.998" "1.209" "0.968" "0.986" "1.240" "1.025" "1.056" "1.138" "1.843" "1458.9" "1456.4" "1763.2" "1411.8" "1438.7" "1808.7" "1496.1" "1540.5" "1660.5" "2688.4" "" "" "" "" "" "" "" "" "" "" "1316.9" "1123.4" "1363.7" "950.7" "1200.1" "1543.7" "1269.1" "1114.9" "1120.0" "2688.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5359713146649655482" "False" "High" "IsMasterProtein" "P31150" "Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2" "0.000" "False" "116.379" "42" "15" "55" "11" "447" "50.6" "5.14" "171.68" "15" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2664" "ENSG00000203879" "GDI1" "hsa:2664; P31150; P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6" "RAB GEFs exchange GTP for GDP on RABs" "Ciliary landscape; Airway smooth muscle cell contraction" "3" "0" "0.994" "1.079" "1.017" "0.990" "1.130" "1.006" "0.972" "1.118" "0.891" "929.2" "923.2" "1002.3" "945.4" "919.7" "1050.2" "934.8" "903.2" "1038.5" "828.4" "" "" "" "" "" "" "" "" "" "" "838.8" "712.1" "775.2" "636.6" "767.2" "896.3" "793.0" "653.6" "700.4" "828.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2214005141303334461" "False" "High" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "0.000" "False" "116.257" "31" "17" "51" "17" "609" "69.8" "6.64" "166.81" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; HDAC6 interactions in the central nervous system" "9" "0" "0.997" "2.374" "1.093" "1.023" "2.339" "1.051" "0.962" "2.394" "3.509" "1549.6" "1544.4" "3678.0" "1693.6" "1586.0" "3624.2" "1629.3" "1491.1" "3709.3" "5436.8" "" "" "" "" "" "" "" "" "" "" "1398.8" "1191.3" "2844.7" "1140.5" "1323.0" "3093.3" "1382.1" "1079.1" "2501.8" "5436.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6011940264998513028" "False" "High" "IsMasterProtein" "O00429" "Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2" "0.000" "False" "116.038" "30" "22" "47" "22" "736" "81.8" "6.81" "149.20" "22" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "10059" "ENSG00000087470" "DNM1L" "A8K4X9; B4DGC9; B4DSU8; G8JLD5; hsa:10059; J3KPI2; O00429; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2" "Apoptotic execution phase" "Synaptic vesicle pathway; CAMKK2 pathway" "3" "0" "0.995" "0.760" "0.966" "0.968" "0.787" "0.977" "0.979" "0.799" "0.772" "2693.1" "2679.5" "2046.9" "2601.6" "2606.7" "2120.7" "2632.0" "2635.3" "2152.6" "2078.2" "" "" "" "" "" "" "" "" "" "" "2431.0" "2066.8" "1583.1" "1751.9" "2174.4" "1810.0" "2232.7" "1907.1" "1451.9" "2078.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4866414538171077072" "False" "High" "IsMasterProtein" "P31146" "Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4" "0.000" "False" "115.987" "36" "17" "65" "16" "461" "51.0" "6.68" "210.33" "17" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf08954, Pf16300" "11151" "ENSG00000102879" "CORO1A" "B2RBL1; hsa:11151; P31146; Q2YD73" "Prevention of phagosomal-lysosomal fusion" "16p11.2 proximal deletion syndrome" "2" "1" "0.932" "0.818" "0.935" "0.929" "0.783" "0.991" "0.934" "0.839" "1.803" "2928.8" "2730.7" "2395.7" "2739.3" "2720.7" "2294.2" "2902.5" "2735.6" "2456.7" "5279.8" "" "" "" "" "" "" "" "" "" "" "2643.7" "2106.3" "1852.9" "1844.7" "2269.5" "1958.1" "2462.1" "1979.8" "1657.0" "5279.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978266596079071295" "False" "High" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "0.000" "False" "115.891" "43" "19" "44" "19" "475" "51.9" "8.06" "141.65" "19" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "7" "0" "0.987" "1.113" "0.991" "0.953" "1.059" "0.977" "1.028" "1.031" "0.761" "2776.2" "2741.5" "3090.4" "2751.3" "2646.2" "2941.3" "2712.7" "2853.2" "2863.6" "2114.1" "" "" "" "" "" "" "" "" "" "" "2506.0" "2114.6" "2390.2" "1852.7" "2207.4" "2510.5" "2301.2" "2064.8" "1931.5" "2114.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-795610127174802190" "False" "High" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "0.000" "False" "115.798" "31" "21" "65" "15" "586" "69.4" "6.27" "202.37" "21" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Sensory processing of sound by outer hair cells of the cochlea; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Netrin-1 signaling" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "11" "1" "0.954" "1.106" "1.042" "0.970" "1.130" "0.987" "0.982" "1.193" "0.726" "2409.3" "2298.8" "2663.8" "2510.0" "2335.9" "2723.2" "2379.0" "2366.4" "2873.6" "1749.3" "" "" "" "" "" "" "" "" "" "" "2174.8" "1773.2" "2060.3" "1690.2" "1948.5" "2324.3" "2018.1" "1712.6" "1938.2" "1749.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337219862284108106" "False" "High" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "0.000" "False" "115.600" "35" "19" "38" "19" "564" "66.7" "6.34" "127.56" "19" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "" "6" "0" "1.022" "0.987" "1.015" "1.028" "0.995" "1.025" "1.017" "0.976" "0.851" "1877.8" "1919.5" "1852.8" "1906.1" "1930.5" "1868.6" "1925.0" "1910.4" "1833.4" "1597.9" "" "" "" "" "" "" "" "" "" "" "1695.0" "1480.6" "1433.0" "1283.6" "1610.4" "1594.8" "1632.9" "1382.6" "1236.6" "1597.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3614500297026839647" "False" "High" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "0.000" "False" "115.447" "44" "14" "45" "14" "331" "38.2" "5.38" "141.56" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; RND2 GTPase cycle; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; PAFAH1B1 copy number variation" "9" "0" "0.949" "0.954" "1.027" "0.972" "0.959" "0.974" "0.946" "0.965" "0.838" "3216.8" "3054.0" "3067.7" "3302.4" "3125.7" "3086.4" "3133.5" "3043.4" "3104.8" "2694.5" "" "" "" "" "" "" "" "" "" "" "2903.7" "2355.7" "2372.6" "2223.8" "2607.3" "2634.3" "2658.1" "2202.5" "2094.1" "2694.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2411801021050745689" "False" "High" "IsMasterProtein" "Q9NSE4" "Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2" "0.000" "False" "115.436" "17" "15" "37" "15" "1012" "113.7" "7.20" "125.34" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00133, Pf06827, Pf08264" "55699" "ENSG00000067704" "IARS2" "B2RPG8; hsa:55699; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NSE4; Q9NW42" "Mitochondrial protein degradation; Mitochondrial tRNA aminoacylation" "" "2" "0" "1.060" "0.966" "1.033" "1.040" "1.011" "1.021" "1.017" "1.003" "0.721" "1874.7" "1987.7" "1811.5" "1936.4" "1948.9" "1895.5" "1913.2" "1906.2" "1880.1" "1352.1" "" "" "" "" "" "" "" "" "" "" "1692.3" "1533.2" "1401.1" "1304.0" "1625.7" "1617.8" "1623.0" "1379.5" "1268.1" "1352.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241887692250600056" "False" "High" "IsMasterProtein" "Q15149" "Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3" "0.000" "False" "115.383" "7" "34" "39" "33" "4684" "531.5" "5.96" "109.84" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00681, Pf03501, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "5339" "ENSG00000178209" "PLEC" "hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383" "Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly" "Envelope proteins and their potential roles in EDMD physiopathology" "4" "0" "0.963" "1.572" "1.102" "0.977" "1.474" "0.976" "0.825" "1.587" "2.608" "1009.6" "972.2" "1587.1" "1112.2" "986.1" "1488.5" "985.0" "833.3" "1602.2" "2633.0" "" "" "" "" "" "" "" "" "" "" "911.3" "749.9" "1227.5" "749.0" "822.5" "1270.4" "835.5" "603.1" "1080.7" "2633.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4471349255838518587" "False" "High" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "0.000" "False" "115.329" "31" "13" "63" "12" "432" "47.7" "6.34" "184.12" "13" "other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications; Spina bifida" "11" "1" "0.978" "0.953" "0.935" "0.992" "0.978" "0.983" "0.946" "0.960" "0.717" "3627.3" "3546.0" "3455.6" "3391.3" "3598.8" "3548.1" "3564.9" "3432.5" "3481.5" "2602.2" "" "" "" "" "" "" "" "" "" "" "3274.3" "2735.2" "2672.6" "2283.7" "3002.0" "3028.4" "3024.1" "2484.1" "2348.3" "2602.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523949865199722082" "False" "High" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "0.000" "False" "115.140" "26" "11" "26" "11" "478" "52.9" "5.82" "92.34" "11" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "Inactivation, recovery and regulation of the phototransduction cascade" "" "1" "0" "0.959" "1.070" "1.018" "0.969" "1.044" "0.929" "0.966" "1.131" "0.791" "1948.4" "1868.1" "2085.6" "1983.2" "1888.3" "2033.2" "1810.9" "1882.9" "2203.2" "1540.4" "" "" "" "" "" "" "" "" "" "" "1758.8" "1440.9" "1613.1" "1335.5" "1575.2" "1735.3" "1536.1" "1362.6" "1486.1" "1540.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5974744531153524067" "False" "High" "IsMasterProtein" "Q01581" "Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCS1 PE=1 SV=2" "0.000" "False" "115.072" "26" "13" "49" "13" "520" "57.3" "5.41" "153.64" "13" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01154, Pf08540" "3157" "ENSG00000112972" "HMGCS1" "B2RDL8; hsa:3157; Q01581" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "13" "0" "0.982" "0.907" "0.931" "0.991" "0.940" "0.995" "0.973" "0.903" "0.708" "3433.5" "3370.1" "3114.3" "3197.6" "3403.5" "3226.1" "3417.8" "3341.6" "3101.5" "2431.4" "" "" "" "" "" "" "" "" "" "" "3099.3" "2599.5" "2408.7" "2153.2" "2839.1" "2753.5" "2899.2" "2418.3" "2092.0" "2431.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338610440228744590" "False" "High" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "0.000" "False" "114.490" "30" "27" "40" "20" "913" "103.9" "7.37" "135.90" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "5" "0.997" "1.003" "1.049" "1.013" "0.994" "0.987" "1.007" "1.009" "0.764" "2728.5" "2721.0" "2735.9" "2862.3" "2763.7" "2712.3" "2692.2" "2746.7" "2751.8" "2085.3" "" "" "" "" "" "" "" "" "" "" "2462.9" "2098.8" "2116.0" "1927.5" "2305.3" "2314.9" "2283.8" "1987.7" "1856.0" "2085.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047119725647514999" "False" "High" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "0.000" "False" "113.934" "22" "13" "44" "13" "611" "69.1" "5.73" "153.40" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "16" "0" "0.964" "1.093" "1.019" "0.980" "1.008" "0.998" "1.093" "1.055" "0.662" "3049.2" "2940.7" "3333.9" "3106.5" "2987.8" "3074.3" "3043.4" "3332.3" "3215.8" "2019.2" "" "" "" "" "" "" "" "" "" "" "2752.5" "2268.3" "2578.5" "2091.9" "2492.3" "2624.0" "2581.7" "2411.5" "2169.0" "2019.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500586164942944818" "False" "High" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "0.000" "False" "113.466" "34" "7" "48" "5" "324" "35.9" "9.88" "178.42" "7" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; mRNA Splicing - Minor Pathway; Noncanonical activation of NOTCH3" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "10" "0" "0.953" "1.129" "0.921" "0.953" "1.119" "0.889" "1.012" "1.060" "0.921" "823.7" "785.1" "929.9" "758.8" "785.2" "921.4" "732.2" "833.8" "873.1" "758.5" "" "" "" "" "" "" "" "" "" "" "743.5" "605.6" "719.2" "510.9" "655.0" "786.4" "621.1" "603.4" "588.9" "758.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117017983706301691" "False" "High" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "0.000" "False" "112.377" "57" "11" "106" "6" "245" "27.7" "4.78" "300.05" "11" "signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "19" "0" "1.008" "0.862" "1.000" "0.997" "0.979" "1.001" "0.985" "0.928" "0.810" "2631.3" "2652.2" "2268.5" "2631.3" "2622.7" "2577.2" "2633.6" "2591.5" "2440.6" "2131.8" "" "" "" "" "" "" "" "" "" "" "2375.2" "2045.7" "1754.6" "1771.9" "2187.7" "2199.7" "2234.1" "1875.5" "1646.2" "2131.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612190288293860915" "False" "High" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "0.000" "False" "112.334" "31" "13" "59" "6" "406" "46.1" "5.48" "165.04" "13" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ISG15 antiviral mechanism; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "13" "9" "0.997" "0.800" "0.997" "1.002" "0.813" "0.981" "0.954" "0.841" "1.230" "3791.6" "3780.8" "3033.9" "3780.7" "3798.2" "3081.4" "3718.5" "3615.3" "3186.9" "4665.2" "" "" "" "" "" "" "" "" "" "" "3422.6" "2916.3" "2346.5" "2545.9" "3168.3" "2630.0" "3154.4" "2616.4" "2149.5" "4665.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3509050462547548554" "False" "High" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "0.000" "False" "112.193" "58" "13" "80" "9" "246" "28.2" "4.84" "230.81" "13" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "11" "0" "0.961" "0.896" "1.024" "0.978" "0.959" "0.963" "0.929" "0.943" "0.868" "1465.0" "1408.0" "1313.3" "1500.8" "1432.6" "1404.3" "1411.5" "1360.9" "1381.3" "1271.6" "" "" "" "" "" "" "" "" "" "" "1322.4" "1086.1" "1015.7" "1010.7" "1195.0" "1198.6" "1197.3" "984.9" "931.7" "1271.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171365705039643338" "False" "High" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "0.000" "False" "111.769" "24" "18" "30" "18" "858" "95.7" "5.03" "106.05" "18" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "IL-18 signaling pathway" "3" "0" "0.998" "0.779" "1.047" "0.991" "0.844" "1.042" "1.003" "0.857" "0.865" "2471.8" "2466.7" "1925.3" "2587.4" "2448.8" "2085.7" "2576.3" "2479.4" "2117.8" "2138.9" "" "" "" "" "" "" "" "" "" "" "2231.3" "1902.7" "1489.1" "1742.3" "2042.7" "1780.2" "2185.5" "1794.3" "1428.4" "2138.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4754969911618934256" "False" "High" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "0.000" "False" "111.758" "23" "16" "31" "16" "873" "97.6" "4.60" "103.90" "16" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "1.035" "0.903" "1.017" "1.000" "0.904" "1.062" "1.041" "0.846" "0.768" "2000.7" "2069.8" "1807.1" "2035.1" "2000.3" "1808.2" "2124.9" "2083.5" "1691.7" "1535.7" "" "" "" "" "" "" "" "" "" "" "1806.0" "1596.5" "1397.7" "1370.4" "1668.5" "1543.4" "1802.5" "1507.8" "1141.0" "1535.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2859585786570282431" "False" "High" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "0.000" "False" "111.668" "28" "18" "37" "15" "780" "85.1" "7.99" "112.59" "18" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Glycolysis" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "1" "1.086" "1.090" "1.112" "1.106" "1.138" "1.116" "1.073" "1.117" "0.815" "760.0" "825.7" "828.2" "845.4" "840.6" "864.7" "848.2" "815.4" "849.2" "619.6" "" "" "" "" "" "" "" "" "" "" "686.0" "636.9" "640.5" "569.3" "701.2" "738.1" "719.5" "590.1" "572.8" "619.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4804495115062908755" "False" "High" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "0.000" "False" "111.603" "21" "23" "37" "23" "1262" "144.4" "6.15" "98.56" "23" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305; ENSG00000291356" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Amino acid metabolism" "3" "0" "1.023" "0.927" "0.972" "1.075" "0.941" "1.003" "0.785" "0.943" "3.075" "577.3" "590.6" "535.5" "561.3" "620.4" "543.4" "579.2" "453.4" "544.4" "1775.0" "" "" "" "" "" "" "" "" "" "" "521.1" "455.5" "414.1" "378.0" "517.5" "463.8" "491.3" "328.1" "367.2" "1775.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7460100142715479081" "False" "High" "IsMasterProtein" "P09960" "Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2" "0.000" "False" "111.568" "25" "14" "33" "14" "611" "69.2" "6.18" "108.06" "14" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf09127, Pf17900" "4048" "ENSG00000111144" "LTA4H" "B4DNQ9; F8VV40; hsa:4048; P09960; Q6IAT6; Q9UCT7" "Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins" "Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "12" "0" "0.985" "0.970" "1.025" "1.006" "1.062" "0.992" "0.978" "1.047" "0.786" "2058.0" "2026.7" "1996.0" "2109.3" "2071.1" "2184.9" "2042.4" "2011.7" "2154.8" "1617.4" "" "" "" "" "" "" "" "" "" "" "1857.7" "1563.3" "1543.8" "1420.4" "1727.7" "1864.8" "1732.6" "1455.8" "1453.4" "1617.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7845595134204648988" "False" "High" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "0.000" "False" "111.506" "22" "16" "30" "16" "845" "95.9" "6.80" "98.43" "16" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "ABC-family proteins mediated transport" "IL-18 signaling pathway" "2" "0" "1.029" "0.899" "0.987" "0.979" "0.886" "0.959" "0.929" "0.909" "0.840" "1850.0" "1903.9" "1663.2" "1825.3" "1811.6" "1638.4" "1773.6" "1718.4" "1681.2" "1554.6" "" "" "" "" "" "" "" "" "" "" "1670.0" "1468.5" "1286.4" "1229.1" "1511.2" "1398.4" "1504.5" "1243.6" "1134.0" "1554.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3092870897652950663" "False" "High" "IsMasterProtein" "O14841" "5-oxoprolinase OS=Homo sapiens OX=9606 GN=OPLAH PE=1 SV=3" "0.000" "False" "111.225" "16" "18" "26" "18" "1288" "137.4" "6.58" "82.51" "18" "other metabolic processes" "cytosol" "other molecular function" "Pf01968, Pf02538, Pf05378, Pf19278" "26873" "ENSG00000178814" "OPLAH" "A5PKY8; hsa:26873; O14841; Q75W65; Q9Y4Q0" "Glutathione synthesis and recycling; Defective OPLAH causes OPLAHD" "Glutathione metabolism" "3" "0" "1.037" "0.851" "1.069" "1.060" "0.891" "1.082" "1.054" "0.902" "0.775" "1062.7" "1102.3" "904.0" "1135.8" "1126.5" "947.1" "1149.6" "1119.8" "958.1" "823.3" "" "" "" "" "" "" "" "" "" "" "959.2" "850.3" "699.2" "764.8" "939.7" "808.3" "975.2" "810.4" "646.2" "823.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205545228874989707" "False" "High" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "0.000" "False" "109.989" "22" "21" "28" "21" "1129" "124.3" "6.61" "100.18" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Pathophysiological roles of DUX4 in FSHD1" "3" "0" "0.990" "0.978" "1.004" "0.985" "0.904" "0.973" "1.032" "0.983" "1.054" "1033.0" "1022.6" "1009.8" "1037.0" "1017.0" "933.5" "1005.3" "1065.7" "1015.1" "1088.9" "" "" "" "" "" "" "" "" "" "" "932.5" "788.8" "781.0" "698.3" "848.4" "796.8" "852.8" "771.2" "684.7" "1088.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1534536598926653536" "False" "High" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "0.000" "False" "109.802" "53" "15" "37" "15" "315" "36.1" "5.08" "126.68" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "21" "0" "1.043" "1.032" "0.906" "1.028" "1.010" "1.003" "1.057" "0.974" "0.758" "1637.4" "1707.6" "1690.3" "1483.2" "1682.5" "1653.0" "1642.4" "1730.6" "1595.3" "1241.1" "" "" "" "" "" "" "" "" "" "" "1478.0" "1317.1" "1307.3" "998.8" "1403.5" "1410.8" "1393.2" "1252.4" "1076.0" "1241.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964393919908826502" "False" "High" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "0.000" "False" "109.361" "38" "14" "28" "14" "432" "46.5" "6.39" "91.42" "14" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "Mitochondrial protein degradation; Citric acid cycle (TCA cycle)" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "5" "0" "1.022" "0.765" "0.961" "1.030" "0.787" "1.040" "1.031" "0.785" "0.759" "1760.0" "1799.2" "1345.5" "1690.5" "1813.1" "1385.6" "1830.8" "1815.1" "1380.9" "1335.4" "" "" "" "" "" "" "" "" "" "" "1588.7" "1387.8" "1040.7" "1138.4" "1512.4" "1182.6" "1553.1" "1313.6" "931.4" "1335.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7405227159340641842" "False" "High" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "0.000" "False" "108.783" "43" "15" "42" "14" "406" "45.6" "7.55" "136.86" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "65" "0" "0.965" "0.738" "0.994" "0.972" "0.786" "0.941" "0.972" "0.807" "0.760" "1634.0" "1576.2" "1206.6" "1624.8" "1587.9" "1284.4" "1538.1" "1587.7" "1319.2" "1242.1" "" "" "" "" "" "" "" "" "" "" "1474.9" "1215.8" "933.3" "1094.2" "1324.6" "1096.3" "1304.7" "1149.0" "889.8" "1242.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365252663665012706" "False" "High" "IsMasterProtein" "P49589" "Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS1 PE=1 SV=3" "0.000" "False" "108.579" "22" "15" "32" "15" "748" "85.4" "6.76" "103.30" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01406" "833" "ENSG00000110619; ENSG00000278191" "CARS1" "hsa:833; P49589; Q53XI8; Q5HYE4; Q9HD24; Q9HD25" "Cytosolic tRNA aminoacylation; Signaling by ALK fusions and activated point mutants" "" "2" "0" "1.021" "0.941" "1.032" "0.965" "0.980" "0.966" "1.002" "0.974" "0.795" "1064.0" "1086.3" "1000.9" "1098.4" "1026.8" "1042.9" "1027.3" "1066.0" "1036.2" "845.4" "" "" "" "" "" "" "" "" "" "" "960.4" "837.9" "774.1" "739.7" "856.5" "890.2" "871.5" "771.5" "698.9" "845.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001879318500673012" "False" "High" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "0.000" "False" "108.517" "27" "16" "41" "12" "636" "70.6" "9.50" "117.95" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "13" "4" "0.970" "0.912" "0.942" "1.025" "0.966" "0.985" "0.966" "0.915" "0.966" "2412.1" "2340.7" "2199.8" "2272.2" "2471.3" "2331.2" "2376.9" "2330.9" "2208.2" "2331.2" "" "" "" "" "" "" "" "" "" "" "2177.4" "1805.4" "1701.4" "1530.1" "2061.5" "1989.7" "2016.3" "1686.8" "1489.4" "2331.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3985188646102169391" "False" "High" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "0.000" "False" "108.059" "26" "13" "32" "13" "499" "56.8" "6.28" "108.82" "13" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "MAPK signaling pathway; ATM signaling in development and disease" "5" "0" "0.988" "1.050" "0.978" "1.005" "1.093" "0.962" "0.966" "1.079" "0.912" "1997.2" "1974.2" "2097.0" "1953.3" "2006.7" "2182.1" "1920.7" "1930.0" "2154.3" "1821.1" "" "" "" "" "" "" "" "" "" "" "1802.8" "1522.8" "1621.9" "1315.3" "1673.9" "1862.4" "1629.3" "1396.7" "1453.0" "1821.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516954531369469772" "False" "High" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "0.000" "False" "107.958" "53" "12" "37" "12" "246" "27.4" "6.76" "119.07" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.981" "1.041" "0.939" "0.998" "1.081" "0.982" "0.964" "1.079" "0.713" "1737.3" "1704.7" "1808.0" "1631.7" "1733.2" "1877.5" "1706.6" "1675.4" "1874.3" "1238.3" "" "" "" "" "" "" "" "" "" "" "1568.2" "1314.9" "1398.4" "1098.8" "1445.8" "1602.4" "1447.7" "1212.5" "1264.2" "1238.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115328096255325213" "False" "High" "IsMasterProtein" "P29966" "Myristoylated alanine-rich C-kinase substrate OS=Homo sapiens OX=9606 GN=MARCKS PE=1 SV=4" "0.000" "False" "107.693" "30" "7" "18" "7" "332" "31.5" "4.45" "84.37" "7" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "4082" "ENSG00000277443" "MARCKS" "E1P560; hsa:4082; P29966; Q2LA83; Q5TDB7" "Acetylcholine regulates insulin secretion" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "2" "0" "1.023" "1.209" "0.996" "0.999" "1.133" "1.055" "1.213" "1.140" "0.729" "1399.6" "1432.5" "1692.6" "1394.0" "1397.6" "1585.3" "1475.9" "1698.0" "1595.1" "1019.8" "" "" "" "" "" "" "" "" "" "" "1263.4" "1104.9" "1309.1" "938.7" "1165.9" "1353.1" "1252.0" "1228.8" "1075.9" "1019.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348431233397446306" "False" "High" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "0.000" "False" "107.257" "32" "12" "35" "12" "437" "49.0" "5.71" "113.08" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "Translation factors" "6" "0" "1.006" "0.932" "0.994" "0.911" "0.974" "0.981" "0.960" "0.920" "0.781" "2504.9" "2521.0" "2335.4" "2488.7" "2281.2" "2440.1" "2456.6" "2405.1" "2303.6" "1957.2" "" "" "" "" "" "" "" "" "" "" "2261.1" "1944.6" "1806.3" "1675.9" "1902.9" "2082.7" "2083.9" "1740.6" "1553.7" "1957.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93919318191628628" "False" "High" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "0.000" "False" "107.053" "30" "19" "34" "19" "740" "82.4" "7.23" "104.28" "19" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "tRNA processing in the nucleus" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "3" "0" "1.005" "0.795" "1.040" "1.032" "0.877" "0.996" "1.000" "0.842" "1.100" "1160.2" "1166.3" "922.0" "1207.2" "1197.1" "1017.8" "1155.2" "1160.2" "976.3" "1276.0" "" "" "" "" "" "" "" "" "" "" "1047.3" "899.6" "713.1" "812.9" "998.5" "868.7" "979.9" "839.6" "658.5" "1276.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054273267636823051" "False" "High" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "0.000" "False" "106.188" "19" "20" "29" "20" "1270" "140.9" "6.84" "94.64" "20" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "mRNA Splicing - Major Pathway; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "MECP2 and associated Rett syndrome; mRNA processing" "6" "0" "1.031" "1.247" "0.959" "1.041" "1.293" "0.977" "0.957" "1.315" "1.204" "711.4" "733.3" "887.1" "681.9" "740.4" "919.8" "695.1" "680.7" "935.6" "856.5" "" "" "" "" "" "" "" "" "" "" "642.2" "565.6" "686.1" "459.2" "617.6" "785.0" "589.6" "492.6" "631.1" "856.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8785242188080332383" "False" "High" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "0.000" "False" "105.891" "32" "15" "35" "15" "519" "56.1" "7.93" "115.63" "15" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "0.989" "1.056" "0.973" "1.032" "1.035" "1.037" "0.968" "1.050" "0.973" "2199.6" "2176.5" "2321.9" "2139.2" "2269.8" "2276.6" "2280.1" "2130.3" "2309.1" "2140.1" "" "" "" "" "" "" "" "" "" "" "1985.5" "1678.8" "1795.8" "1440.5" "1893.4" "1943.1" "1934.2" "1541.7" "1557.5" "2140.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6019619507196981202" "False" "High" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "0.000" "False" "105.310" "35" "14" "51" "14" "418" "47.3" "5.88" "149.67" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Physico-chemical features and toxicity-associated pathways" "6" "0" "1.053" "1.084" "0.953" "0.997" "1.110" "0.978" "1.039" "1.108" "0.767" "2003.3" "2108.8" "2171.6" "1908.9" "1998.0" "2223.5" "1958.6" "2080.5" "2218.9" "1536.0" "" "" "" "" "" "" "" "" "" "" "1808.3" "1626.6" "1679.6" "1285.5" "1666.6" "1897.8" "1661.4" "1505.6" "1496.7" "1536.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2006906941817689569" "False" "High" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "0.000" "False" "105.048" "8" "22" "27" "21" "2896" "316.7" "9.13" "100.68" "22" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "" "VEGFA-VEGFR2 signaling" "1" "1" "1.005" "1.097" "0.996" "1.047" "1.089" "1.036" "1.076" "1.053" "0.739" "2552.7" "2566.3" "2800.5" "2542.8" "2673.5" "2780.4" "2643.3" "2746.5" "2686.7" "1886.7" "" "" "" "" "" "" "" "" "" "" "2304.2" "1979.5" "2166.0" "1712.3" "2230.1" "2373.1" "2242.3" "1987.6" "1812.2" "1886.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5486623488286150829" "False" "High" "IsMasterProtein" "Q9UBT2" "SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2" "0.000" "False" "104.557" "22" "13" "39" "13" "640" "71.2" "5.29" "123.07" "13" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00899, Pf14732, Pf16195" "10054" "ENSG00000126261" "UBA2" "B3KWB9; hsa:10054; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UBT2; Q9UED2" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "" "2" "0" "0.971" "0.952" "0.928" "0.905" "0.946" "0.970" "0.920" "0.941" "0.802" "2449.6" "2379.3" "2333.0" "2273.9" "2217.6" "2318.5" "2377.0" "2252.7" "2305.2" "1963.5" "" "" "" "" "" "" "" "" "" "" "2211.2" "1835.3" "1804.4" "1531.3" "1849.9" "1978.8" "2016.4" "1630.2" "1554.8" "1963.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100878916131084887" "False" "High" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "0.000" "False" "104.530" "30" "15" "33" "15" "562" "61.4" "6.76" "108.88" "15" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Galactose catabolism; Defective PGM1 causes PGM1-CDG" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "13" "0" "1.038" "1.055" "1.070" "1.018" "1.092" "1.065" "1.007" "1.100" "0.773" "1778.7" "1846.9" "1876.3" "1903.9" "1810.1" "1942.9" "1894.0" "1790.4" "1957.1" "1375.3" "" "" "" "" "" "" "" "" "" "" "1605.6" "1424.6" "1451.2" "1282.1" "1509.9" "1658.3" "1606.6" "1295.7" "1320.0" "1375.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2641060010654775307" "False" "High" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "0.000" "False" "104.030" "34" "14" "41" "14" "456" "52.9" "7.65" "104.32" "14" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "0.972" "0.763" "0.932" "1.008" "0.782" "0.968" "0.960" "0.754" "0.850" "1923.7" "1869.8" "1467.8" "1792.6" "1938.3" "1504.4" "1861.4" "1847.4" "1450.8" "1635.7" "" "" "" "" "" "" "" "" "" "" "1736.5" "1442.3" "1135.2" "1207.1" "1616.8" "1284.0" "1579.0" "1337.0" "978.6" "1635.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573654140983497752" "False" "High" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "0.000" "False" "103.955" "46" "11" "48" "11" "261" "28.8" "4.69" "157.17" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; NF1 copy number variation syndrome ; Rubinstein-Taybi syndrome 1" "47" "0" "1.046" "1.030" "1.042" "1.031" "1.098" "1.004" "1.033" "1.107" "0.729" "2513.0" "2628.3" "2588.6" "2618.8" "2590.2" "2758.4" "2523.1" "2596.1" "2783.0" "1831.7" "" "" "" "" "" "" "" "" "" "" "2268.4" "2027.3" "2002.1" "1763.5" "2160.6" "2354.3" "2140.3" "1878.8" "1877.1" "1831.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653265809957974706" "False" "High" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "0.000" "False" "103.841" "17" "14" "32" "14" "1087" "114.5" "7.11" "114.10" "14" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.976" "1.061" "0.977" "1.010" "1.013" "1.034" "1.081" "0.944" "0.714" "2462.4" "2404.0" "2611.6" "2405.0" "2487.1" "2493.5" "2545.5" "2661.7" "2325.0" "1759.3" "" "" "" "" "" "" "" "" "" "" "2222.7" "1854.3" "2019.9" "1619.5" "2074.7" "2128.2" "2159.3" "1926.3" "1568.2" "1759.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3757999433169180156" "False" "High" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "0.000" "False" "103.565" "16" "21" "31" "21" "1288" "147.1" "6.79" "104.01" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "Ciliary landscape" "3" "0" "0.997" "0.811" "0.961" "0.954" "0.799" "0.974" "0.926" "0.860" "1.694" "1945.9" "1939.3" "1578.4" "1870.9" "1857.1" "1554.2" "1895.7" "1802.3" "1673.5" "3295.9" "" "" "" "" "" "" "" "" "" "" "1756.5" "1495.9" "1220.8" "1259.8" "1549.1" "1326.6" "1608.1" "1304.3" "1128.7" "3295.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369524592651400068" "False" "High" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "0.000" "False" "103.073" "43" "19" "51" "19" "491" "55.5" "7.15" "168.99" "19" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "9" "0" "1.015" "1.034" "1.014" "1.047" "1.124" "1.007" "1.006" "1.080" "0.745" "3751.3" "3809.3" "3877.3" "3805.4" "3927.8" "4216.2" "3778.8" "3774.1" "4052.9" "2794.4" "" "" "" "" "" "" "" "" "" "" "3386.2" "2938.3" "2998.8" "2562.5" "3276.4" "3598.6" "3205.5" "2731.3" "2733.6" "2794.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6180366262275080504" "False" "High" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "0.000" "False" "103.064" "31" "13" "51" "13" "430" "47.5" "9.01" "160.77" "13" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "11" "0" "1.002" "1.099" "0.949" "0.998" "1.175" "0.995" "0.992" "1.135" "0.643" "3679.3" "3688.1" "4045.1" "3492.0" "3672.9" "4321.3" "3659.4" "3648.9" "4177.6" "2365.8" "" "" "" "" "" "" "" "" "" "" "3321.2" "2844.8" "3128.6" "2351.5" "3063.8" "3688.3" "3104.2" "2640.7" "2817.7" "2365.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3264594850844257822" "False" "High" "IsMasterProtein" "P50440" "Glycine amidinotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GATM PE=1 SV=1" "0.000" "False" "103.000" "36" "13" "34" "13" "423" "48.4" "8.05" "112.46" "13" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "" "2628" "ENSG00000171766" "GATM" "B4DH99; B4DPI3; hsa:2628; P50440; Q53EQ4" "Creatine metabolism" "Creatine pathway" "2" "0" "1.081" "1.145" "1.003" "1.083" "1.273" "1.056" "1.087" "1.182" "0.776" "1877.1" "2028.3" "2148.5" "1882.5" "2032.6" "2389.5" "1981.7" "2040.0" "2218.7" "1457.1" "" "" "" "" "" "" "" "" "" "" "1694.4" "1564.5" "1661.8" "1267.7" "1695.5" "2039.5" "1681.0" "1476.3" "1496.5" "1457.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4081821255654730279" "False" "High" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "0.000" "False" "102.960" "22" "18" "24" "18" "768" "88.9" "8.48" "78.91" "18" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of DVL; Hedgehog 'on' state; Regulation of RAS by GAPs; Neddylation; KEAP1-NFE2L2 pathway; RHOBTB3 ATPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "16" "0" "0.961" "0.915" "1.002" "0.925" "0.914" "0.987" "1.008" "0.937" "0.697" "913.4" "877.6" "835.5" "915.2" "844.7" "835.1" "901.3" "921.0" "856.0" "636.6" "" "" "" "" "" "" "" "" "" "" "824.5" "677.0" "646.2" "616.3" "704.6" "712.8" "764.6" "666.5" "577.4" "636.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7238306351176714360" "False" "High" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "0.000" "False" "102.856" "24" "18" "32" "18" "876" "97.1" "4.78" "99.11" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Neutrophil degranulation; Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Interferon alpha/beta signaling; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Assembly of the ORC complex at the origin of replication; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "15" "0" "0.981" "1.173" "1.191" "0.961" "1.186" "0.954" "0.857" "1.382" "2.282" "1182.0" "1159.1" "1386.3" "1408.1" "1135.4" "1402.2" "1127.3" "1013.4" "1633.3" "2697.6" "" "" "" "" "" "" "" "" "" "" "1067.0" "894.0" "1072.2" "948.2" "947.1" "1196.8" "956.2" "733.4" "1101.6" "2697.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5288684708523747991" "False" "High" "IsMasterProtein" "Q14240" "Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2" "0.000" "False" "102.854" "34" "13" "50" "6" "407" "46.4" "5.48" "136.15" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1974" "ENSG00000156976" "EIF4A2" "D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Z-decay: degradation of maternal mRNAs by zygotically expressed factors; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "11" "0" "1.028" "0.957" "0.986" "1.029" "0.944" "1.036" "1.003" "1.043" "0.772" "450.6" "463.1" "431.0" "444.2" "463.6" "425.5" "466.7" "451.9" "470.1" "347.6" "" "" "" "" "" "" "" "" "" "" "406.7" "357.2" "333.4" "299.1" "386.7" "363.2" "395.9" "327.1" "317.1" "347.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7989790464056543145" "False" "High" "IsMasterProtein" "Cont_P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "0.000" "True" "102.818" "26" "14" "26" "13" "623" "62.0" "5.24" "92.78" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "3857; 454664" "ENSG00000171403; ENSPTRG00000009169" "KRT9" "A0A2J8KG96; A0A6D2VYW7; H2QCZ6; hsa:3857; O00109; P35527; ptr:454664; Q0IJ47; Q14665" "Formation of the cornified envelope" "" "2" "0" "0.880" "2.045" "1.144" "0.716" "0.343" "0.835" "0.615" "0.797" "0.639" "1595.1" "1403.0" "3261.4" "1825.5" "1142.7" "547.3" "1331.8" "980.5" "1272.0" "1019.5" "" "" "" "" "" "" "" "" "" "" "1439.9" "1082.2" "2522.4" "1229.3" "953.2" "467.2" "1129.8" "709.6" "858.0" "1019.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3779865839115366179" "False" "High" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "0.000" "False" "102.490" "28" "16" "40" "16" "558" "61.4" "7.80" "121.62" "16" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; Glutamate and glutamine metabolism" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation" "9" "0" "0.995" "1.124" "0.981" "0.982" "1.176" "0.938" "0.986" "1.142" "0.501" "2363.7" "2352.8" "2656.1" "2319.7" "2320.8" "2780.3" "2216.5" "2330.7" "2700.5" "1184.2" "" "" "" "" "" "" "" "" "" "" "2133.7" "1814.8" "2054.3" "1562.1" "1935.9" "2373.1" "1880.2" "1686.7" "1821.4" "1184.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781846477469752128" "False" "High" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "0.000" "False" "102.306" "31" "17" "33" "17" "617" "68.3" "5.52" "103.17" "17" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "1.002" "1.031" "1.020" "1.042" "1.073" "1.012" "1.017" "1.021" "0.860" "2219.5" "2224.8" "2289.2" "2263.6" "2312.5" "2382.3" "2246.3" "2258.1" "2265.8" "1908.3" "" "" "" "" "" "" "" "" "" "" "2003.5" "1716.1" "1770.6" "1524.3" "1929.0" "2033.3" "1905.5" "1634.1" "1528.3" "1908.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283450593618715734" "False" "High" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "0.000" "False" "101.911" "30" "13" "38" "13" "450" "50.7" "7.06" "118.61" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "P41240; Q2M3N2; Q6FGZ6" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Negative regulation of FLT3; Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; GAB1 signalosome; Integrin signaling; RHOH GTPase cycle" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "18" "0" "0.981" "0.730" "0.901" "0.960" "0.726" "0.932" "0.922" "0.712" "1.556" "1524.0" "1495.5" "1112.7" "1372.6" "1463.3" "1105.7" "1420.0" "1405.4" "1085.4" "2371.6" "" "" "" "" "" "" "" "" "" "" "1375.7" "1153.5" "860.6" "924.3" "1220.6" "943.7" "1204.6" "1017.1" "732.1" "2371.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5241599952766811941" "False" "High" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "0.000" "False" "101.793" "37" "6" "93" "6" "210" "23.3" "5.64" "335.58" "6" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Neutrophil degranulation; Paracetamol ADME; Detoxification of Reactive Oxygen Species; Glutathione conjugation" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "11" "0" "1.012" "0.855" "1.011" "1.075" "0.944" "1.032" "1.048" "0.921" "0.807" "2895.8" "2930.7" "2476.0" "2928.9" "3112.6" "2734.6" "2987.9" "3035.4" "2666.7" "2335.5" "" "" "" "" "" "" "" "" "" "" "2614.0" "2260.6" "1915.0" "1972.3" "2596.4" "2334.0" "2534.6" "2196.7" "1798.6" "2335.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1891313115093296053" "False" "High" "IsMasterProtein" "P21980" "Protein-glutamine gamma-glutamyltransferase 2 OS=Homo sapiens OX=9606 GN=TGM2 PE=1 SV=2" "0.000" "False" "101.789" "23" "15" "35" "15" "687" "77.3" "5.22" "114.10" "15" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00868, Pf00927, Pf01841" "7052" "ENSG00000198959" "TGM2" "E1P5V9; hsa:7052; P21980; Q16436; Q6B838; Q9BTN7; Q9H035; Q9UH35" "" "IL-18 signaling pathway" "1" "0" "1.001" "0.910" "0.977" "1.004" "0.940" "0.961" "0.993" "0.951" "0.814" "2007.7" "2009.2" "1826.8" "1960.6" "2014.7" "1886.2" "1928.7" "1993.3" "1909.6" "1633.9" "" "" "" "" "" "" "" "" "" "" "1812.3" "1549.8" "1412.9" "1320.3" "1680.6" "1609.9" "1636.1" "1442.6" "1288.0" "1633.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6719730535871434509" "False" "High" "IsMasterProtein" "P16989" "Y-box-binding protein 3 OS=Homo sapiens OX=9606 GN=YBX3 PE=1 SV=4" "0.000" "False" "101.743" "36" "9" "35" "7" "372" "40.1" "9.77" "132.16" "9" "stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00313" "8531" "ENSG00000060138" "YBX3" "B2RBW6; hsa:8531; P16989; Q14121; Q969N6; Q96B76" "" "RalA downstream regulated genes; Apoptosis-related network due to altered Notch3 in ovarian cancer" "2" "2" "1.029" "1.045" "1.064" "0.972" "1.088" "0.992" "1.056" "1.035" "0.913" "1445.0" "1487.5" "1509.6" "1537.6" "1404.1" "1572.5" "1434.1" "1525.9" "1495.5" "1319.8" "" "" "" "" "" "" "" "" "" "" "1304.4" "1147.4" "1167.6" "1035.4" "1171.2" "1342.2" "1216.5" "1104.3" "1008.7" "1319.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "964900113043376779" "False" "High" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "0.000" "False" "101.584" "41" "13" "27" "13" "456" "50.2" "6.42" "84.23" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "UCH proteinases; Ub-specific processing proteases; DNA Damage Recognition in GG-NER; HATs acetylate histones; Deposition of new CENPA-containing nucleosomes at the centromere; Formation of the beta-catenin:TCF transactivating complex; Telomere Extension By Telomerase" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "9" "0" "0.968" "0.962" "0.942" "0.945" "0.926" "0.990" "0.938" "0.949" "1.026" "931.0" "900.8" "895.7" "877.2" "879.6" "862.1" "921.8" "873.4" "883.9" "954.9" "" "" "" "" "" "" "" "" "" "" "840.4" "694.8" "692.8" "590.7" "733.7" "735.8" "782.0" "632.1" "596.2" "954.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2355880035621835112" "False" "High" "IsMasterProtein" "O15067" "Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4" "0.000" "False" "101.561" "15" "18" "27" "18" "1338" "144.6" "5.76" "90.35" "18" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02769, Pf13507, Pf18072, Pf18076" "5198" "ENSG00000178921" "PFAS" "A6H8V8; hsa:5198; O15067" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "0.883" "0.646" "0.849" "0.833" "0.633" "0.795" "0.772" "0.619" "0.987" "1093.7" "965.3" "706.3" "928.7" "910.6" "692.4" "869.7" "844.3" "677.4" "1079.2" "" "" "" "" "" "" "" "" "" "" "987.2" "744.6" "546.3" "625.4" "759.5" "591.0" "737.7" "611.0" "456.9" "1079.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200124319077870265" "False" "High" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "0.000" "False" "100.938" "42" "16" "42" "16" "433" "48.6" "5.95" "122.66" "16" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862, Pf21236" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; Neutrophil degranulation; The role of GTSE1 in G2/M progression after G2 checkpoint; Downstream TCR signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "0.988" "0.741" "0.939" "0.995" "0.800" "0.981" "0.983" "0.783" "0.865" "1940.5" "1916.8" "1438.4" "1823.0" "1930.9" "1552.6" "1904.5" "1907.9" "1519.2" "1678.4" "" "" "" "" "" "" "" "" "" "" "1751.6" "1478.5" "1112.5" "1227.6" "1610.7" "1325.2" "1615.6" "1380.7" "1024.7" "1678.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364177795992672609" "False" "High" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "0.000" "False" "100.567" "41" "12" "38" "12" "397" "41.9" "8.09" "124.05" "12" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Mitochondrial Fatty Acid Beta-Oxidation" "Fatty acid biosynthesis" "2" "0" "1.054" "0.974" "0.905" "1.023" "1.014" "1.075" "1.100" "0.976" "0.633" "1388.0" "1462.9" "1352.0" "1256.2" "1419.8" "1406.9" "1492.4" "1526.5" "1355.0" "878.4" "" "" "" "" "" "" "" "" "" "" "1253.0" "1128.4" "1045.7" "845.9" "1184.3" "1200.8" "1266.0" "1104.7" "913.9" "878.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4784462983212685670" "False" "High" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "0.000" "False" "100.506" "36" "13" "41" "13" "475" "52.8" "5.97" "134.71" "13" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "Glutathione synthesis and recycling; Paracetamol ADME" "" "2" "0" "0.948" "1.096" "0.957" "0.905" "1.087" "0.948" "0.934" "1.048" "0.822" "2377.4" "2254.6" "2604.8" "2274.8" "2150.7" "2584.9" "2254.7" "2220.5" "2492.0" "1953.8" "" "" "" "" "" "" "" "" "" "" "2146.0" "1739.1" "2014.7" "1531.8" "1794.0" "2206.3" "1912.6" "1607.0" "1680.8" "1953.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952006714438079555" "False" "High" "IsMasterProtein" "Q9Y4L1" "Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1" "0.000" "False" "100.092" "26" "22" "33" "22" "999" "111.3" "5.22" "100.70" "22" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00012" "10525" "ENSG00000149428; ENSG00000280682" "HYOU1" "A8C1Z0; B7Z909; hsa:10525; Q2I204; Q53H25; Q9Y4L1" "XBP1(S) activates chaperone genes; Scavenging by Class F Receptors" "VEGFA-VEGFR2 signaling" "3" "0" "1.141" "1.108" "1.039" "1.142" "1.095" "1.136" "1.089" "1.044" "1.695" "1412.2" "1611.6" "1564.6" "1467.2" "1612.2" "1546.0" "1604.8" "1537.8" "1474.8" "2393.9" "" "" "" "" "" "" "" "" "" "" "1274.8" "1243.1" "1210.2" "988.0" "1344.8" "1319.5" "1361.4" "1112.9" "994.7" "2393.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6928651678899214990" "False" "High" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "0.000" "False" "99.953" "21" "15" "22" "15" "953" "106.3" "8.32" "81.63" "15" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "1.047" "1.686" "1.031" "1.048" "1.481" "1.114" "1.084" "1.598" "1.035" "978.2" "1024.0" "1649.2" "1008.5" "1024.9" "1448.6" "1089.5" "1060.5" "1563.6" "1012.6" "" "" "" "" "" "" "" "" "" "" "883.0" "789.9" "1275.5" "679.1" "854.9" "1236.4" "924.2" "767.5" "1054.6" "1012.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2098807042560158640" "False" "High" "IsMasterProtein" "P13489" "Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2" "0.000" "False" "99.904" "25" "11" "29" "11" "461" "49.9" "4.82" "107.99" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf13516, Pf18779" "6050" "ENSG00000023191; ENSG00000276230" "RNH1" "hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6" "" "" "0" "0" "0.992" "0.791" "1.002" "0.983" "0.802" "0.987" "1.028" "0.828" "0.762" "2222.8" "2204.6" "1757.1" "2227.0" "2185.4" "1783.5" "2193.4" "2286.1" "1840.5" "1694.8" "" "" "" "" "" "" "" "" "" "" "2006.4" "1700.5" "1359.0" "1499.7" "1823.0" "1522.2" "1860.6" "1654.4" "1241.4" "1694.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7622231560690593168" "False" "High" "IsMasterProtein" "Q13043" "Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2" "0.000" "False" "99.713" "29" "14" "32" "10" "487" "55.6" "5.07" "91.21" "14" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6789" "ENSG00000101109" "STK4" "B2RCR8; hsa:6789; Q13043; Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4" "Signaling by Hippo" "MAPK signaling pathway; Ras signaling; Non-small cell lung cancer" "4" "2" "1.050" "0.850" "0.951" "0.985" "0.875" "0.994" "0.974" "0.849" "0.768" "1807.8" "1897.9" "1536.3" "1719.5" "1781.6" "1582.0" "1797.8" "1760.3" "1535.5" "1389.0" "" "" "" "" "" "" "" "" "" "" "1631.9" "1463.9" "1188.2" "1157.9" "1486.1" "1350.2" "1525.0" "1273.9" "1035.7" "1389.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394918450034897638" "False" "High" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "0.000" "False" "99.270" "20" "15" "29" "15" "814" "92.4" "5.00" "105.23" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.956" "1.027" "1.008" "0.962" "1.001" "0.990" "0.855" "1.019" "2.782" "818.1" "782.0" "840.3" "824.2" "787.1" "818.6" "810.1" "699.8" "833.2" "2275.7" "" "" "" "" "" "" "" "" "" "" "738.4" "603.2" "649.9" "555.0" "656.6" "698.7" "687.2" "506.4" "562.0" "2275.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1039523901046503215" "False" "High" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "0.000" "False" "98.754" "17" "25" "31" "25" "1394" "157.8" "6.13" "92.52" "25" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial RNA degradation" "Ciliary landscape" "5" "0" "1.114" "1.125" "1.167" "1.201" "1.081" "1.176" "0.158" "1.179" "19.789" "459.8" "512.0" "517.1" "536.3" "552.4" "496.8" "540.5" "72.7" "542.0" "9098.1" "" "" "" "" "" "" "" "" "" "" "415.0" "395.0" "400.0" "361.2" "460.8" "424.1" "458.5" "52.6" "365.6" "9098.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990763445808986334" "False" "High" "IsMasterProtein" "O75083" "WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4" "0.000" "False" "98.481" "31" "16" "36" "16" "606" "66.2" "6.65" "124.63" "16" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00400" "9948" "ENSG00000071127" "WDR1" "A8K6E9; A8MPU4; hsa:9948; O75083; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0" "Platelet degranulation" "Hypertrophy model" "2" "0" "0.987" "1.061" "0.966" "0.959" "1.079" "0.983" "1.022" "1.041" "0.780" "2849.2" "2812.5" "3024.3" "2753.3" "2731.4" "3075.3" "2799.6" "2912.3" "2966.2" "2221.4" "" "" "" "" "" "" "" "" "" "" "2571.9" "2169.4" "2339.1" "1854.0" "2278.4" "2624.8" "2374.9" "2107.6" "2000.7" "2221.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618262664170988145" "False" "High" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "0.000" "False" "98.033" "35" "16" "64" "16" "463" "50.9" "5.54" "195.19" "16" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "HCMV Late Events; SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "6" "0" "1.040" "1.014" "1.089" "1.067" "0.985" "1.042" "0.964" "1.007" "1.725" "3507.7" "3649.2" "3557.6" "3819.2" "3742.5" "3455.4" "3656.6" "3383.0" "3531.0" "6049.2" "" "" "" "" "" "" "" "" "" "" "3166.3" "2814.8" "2751.6" "2571.8" "3121.9" "2949.3" "3101.8" "2448.2" "2381.6" "6049.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642176776796334220" "False" "High" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "0.000" "False" "98.031" "8" "15" "42" "6" "1976" "228.9" "5.54" "148.06" "15" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "EPHA-mediated growth cone collapse; RHO GTPases activate PAKs; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs" "Regulation of actin cytoskeleton" "7" "0" "1.034" "1.024" "0.972" "0.929" "0.960" "0.990" "0.970" "1.101" "1.252" "346.8" "358.6" "355.0" "337.2" "322.0" "333.0" "343.2" "336.5" "382.0" "434.2" "" "" "" "" "" "" "" "" "" "" "313.0" "276.6" "274.6" "227.1" "268.6" "284.2" "291.2" "243.6" "257.6" "434.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405603430523799899" "False" "High" "IsMasterProtein" "P52888" "Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2" "0.000" "False" "97.865" "31" "21" "39" "21" "689" "78.8" "6.05" "122.90" "21" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01432" "7064" "ENSG00000172009" "THOP1" "B3KSE2; hsa:7064; P52888; Q9UCB3" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.025" "1.009" "1.018" "1.001" "1.025" "0.995" "0.999" "1.038" "0.722" "2994.3" "3069.1" "3022.6" "3046.8" "2997.2" "3068.9" "2980.3" "2991.3" "3106.7" "2163.3" "" "" "" "" "" "" "" "" "" "" "2702.9" "2367.4" "2337.8" "2051.7" "2500.2" "2619.4" "2528.1" "2164.8" "2095.4" "2163.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5876331061237715446" "False" "High" "IsMasterProtein" "Q14247" "Src substrate cortactin OS=Homo sapiens OX=9606 GN=CTTN PE=1 SV=2" "0.000" "False" "97.720" "34" "17" "26" "17" "550" "61.5" "5.40" "87.80" "17" "cell adhesion;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf02218, Pf14604" "2017" "ENSG00000085733; ENSG00000288401" "CTTN" "hsa:2017; Q14247; Q8N707; Q96H99" "Clathrin-mediated endocytosis; RHO GTPases activate PAKs" "Pathogenic Escherichia coli infection; Hepatitis C and hepatocellular carcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP; HDAC6 interactions in the central nervous system" "6" "0" "0.974" "0.816" "0.910" "1.013" "0.914" "0.962" "1.042" "0.883" "0.667" "2021.0" "1969.4" "1648.4" "1838.2" "2046.4" "1847.9" "1943.6" "2106.8" "1785.1" "1347.4" "" "" "" "" "" "" "" "" "" "" "1824.3" "1519.1" "1275.0" "1237.8" "1707.0" "1577.2" "1648.7" "1524.7" "1204.0" "1347.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "565785606400917725" "False" "High" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "0.000" "False" "97.718" "29" "20" "43" "20" "723" "83.4" "6.67" "129.92" "20" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "Cytosolic tRNA aminoacylation" "" "1" "0" "0.946" "0.957" "0.946" "0.923" "1.003" "0.896" "0.902" "0.963" "0.918" "2156.1" "2040.6" "2064.1" "2040.5" "1990.1" "2162.3" "1932.1" "1943.9" "2076.8" "1978.4" "" "" "" "" "" "" "" "" "" "" "1946.3" "1574.0" "1596.4" "1374.0" "1660.0" "1845.5" "1638.9" "1406.8" "1400.8" "1978.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5545156882891984968" "False" "High" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "0.000" "False" "97.710" "26" "12" "37" "12" "510" "54.6" "8.76" "114.52" "12" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "1.007" "0.958" "1.034" "1.055" "0.936" "1.016" "1.025" "0.948" "0.697" "2561.8" "2580.2" "2454.9" "2649.7" "2701.7" "2396.6" "2603.0" "2626.6" "2429.3" "1785.3" "" "" "" "" "" "" "" "" "" "" "2312.5" "1990.2" "1898.7" "1784.3" "2253.6" "2045.5" "2208.1" "1900.8" "1638.6" "1785.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6072286448447602827" "False" "High" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "0.000" "False" "97.226" "36" "12" "30" "12" "346" "38.4" "5.30" "112.13" "12" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "" "2" "0" "0.943" "0.941" "0.912" "0.943" "0.974" "0.973" "0.938" "0.990" "0.805" "2050.9" "1934.2" "1929.0" "1870.9" "1933.6" "1996.8" "1995.5" "1924.1" "2031.0" "1651.1" "" "" "" "" "" "" "" "" "" "" "1851.3" "1492.0" "1491.9" "1259.8" "1612.9" "1704.3" "1692.7" "1392.4" "1369.9" "1651.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636491781207187808" "False" "High" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "0.000" "False" "96.587" "40" "19" "32" "19" "501" "57.1" "6.55" "109.99" "19" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Alanine and aspartate metabolism" "3" "0" "1.031" "0.808" "1.009" "1.050" "0.827" "0.985" "0.948" "0.813" "1.592" "1869.6" "1928.3" "1510.6" "1887.3" "1963.6" "1545.6" "1842.1" "1772.4" "1519.2" "2975.9" "" "" "" "" "" "" "" "" "" "" "1687.7" "1487.4" "1168.4" "1270.9" "1638.0" "1319.2" "1562.6" "1282.7" "1024.7" "2975.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1108045160068185156" "False" "High" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "0.000" "False" "96.485" "29" "13" "30" "13" "488" "52.7" "5.68" "93.30" "13" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "" "0" "0" "1.052" "1.131" "1.044" "1.123" "1.064" "1.055" "1.113" "1.149" "0.913" "876.8" "922.6" "991.7" "915.5" "984.7" "933.3" "925.1" "976.3" "1007.3" "800.8" "" "" "" "" "" "" "" "" "" "" "791.5" "711.6" "767.0" "616.5" "821.4" "796.6" "784.7" "706.5" "679.4" "800.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8809117759024256443" "False" "High" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "0.000" "False" "96.472" "44" "10" "33" "9" "281" "31.1" "5.01" "125.55" "10" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Eukaryotic Translation Elongation" "Translation factors" "2" "1" "0.922" "0.830" "0.946" "0.906" "0.806" "0.958" "0.927" "0.782" "1.132" "1885.2" "1738.7" "1563.8" "1783.1" "1708.8" "1519.1" "1806.8" "1748.4" "1474.4" "2134.2" "" "" "" "" "" "" "" "" "" "" "1701.7" "1341.2" "1209.5" "1200.7" "1425.4" "1296.5" "1532.7" "1265.3" "994.5" "2134.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1422761924457517511" "False" "High" "IsMasterProtein" "A3KN83" "Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1" "0.000" "False" "96.286" "15" "18" "25" "18" "1393" "154.2" "7.88" "73.88" "18" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "55206" "ENSG00000139697" "SBNO1" "A3KN83; Q05C06; Q3ZTS3; Q9H3T8; Q9NVB2" "" "" "0" "0" "0.999" "0.924" "1.000" "0.996" "0.918" "1.066" "1.022" "0.905" "0.943" "1038.2" "1037.4" "959.6" "1038.3" "1034.0" "952.9" "1107.0" "1060.6" "939.2" "978.9" "" "" "" "" "" "" "" "" "" "" "937.1" "800.2" "742.2" "699.2" "862.6" "813.3" "939.0" "767.5" "633.5" "978.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501130865097894528" "False" "High" "IsMasterProtein" "O60763" "General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2" "0.000" "False" "96.272" "15" "14" "28" "14" "962" "107.8" "4.91" "92.55" "14" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf04869, Pf04871, Pf18770" "8615" "ENSG00000138768" "USO1" "B2RAQ0; hsa:8615; O60763; Q6PK63; Q86TB8; Q8N592" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "" "3" "0" "0.965" "0.856" "0.925" "0.988" "0.899" "1.022" "0.971" "0.868" "1.061" "1332.0" "1285.7" "1139.8" "1231.8" "1315.7" "1197.2" "1361.9" "1293.7" "1155.7" "1413.4" "" "" "" "" "" "" "" "" "" "" "1202.4" "991.7" "881.6" "829.5" "1097.5" "1021.8" "1155.3" "936.3" "779.5" "1413.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8952953409399985954" "False" "High" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "0.000" "False" "95.809" "44" "9" "32" "9" "243" "27.3" "5.08" "127.77" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "0.985" "1.615" "1.011" "1.042" "1.517" "1.039" "1.116" "1.542" "0.766" "2347.2" "2310.8" "3791.0" "2373.1" "2445.4" "3560.1" "2437.9" "2620.0" "3619.7" "1798.8" "" "" "" "" "" "" "" "" "" "" "2118.7" "1782.5" "2932.1" "1598.0" "2039.9" "3038.6" "2068.0" "1896.1" "2441.5" "1798.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6444296704773161539" "False" "High" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "0.000" "False" "95.767" "29" "18" "27" "18" "589" "66.1" "6.84" "87.69" "18" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "Cytosolic tRNA aminoacylation" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "3" "0" "0.977" "0.826" "0.886" "0.978" "0.817" "0.998" "0.952" "0.785" "1.350" "2384.7" "2329.4" "1969.2" "2111.9" "2331.5" "1948.1" "2378.7" "2270.5" "1871.9" "3220.5" "" "" "" "" "" "" "" "" "" "" "2152.6" "1796.8" "1523.1" "1422.2" "1944.9" "1662.8" "2017.8" "1643.1" "1262.6" "3220.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8002824658858050550" "False" "High" "IsMasterProtein" "Q13087" "Protein disulfide-isomerase A2 OS=Homo sapiens OX=9606 GN=PDIA2 PE=1 SV=2" "0.000" "False" "95.541" "29" "14" "24" "14" "525" "58.2" "4.98" "79.54" "14" "cell adhesion;protein metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf13848" "64714" "ENSG00000185615" "PDIA2" "A6ZJ64; B4DI27; hsa:64714; Q13087; Q2WGM4; Q4TT67; Q6B010; Q96KJ6; Q9BW95" "" "Statin inhibition of cholesterol production; Familial hyperlipidemia type 4" "2" "0" "1.014" "0.981" "1.057" "1.020" "0.998" "1.009" "1.011" "1.010" "1.009" "1190.5" "1206.8" "1167.7" "1258.5" "1214.2" "1187.8" "1201.2" "1204.1" "1202.5" "1201.7" "" "" "" "" "" "" "" "" "" "" "1074.7" "930.9" "903.1" "847.5" "1012.9" "1013.8" "1018.9" "871.4" "811.1" "1201.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909350322516910922" "False" "High" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "0.000" "False" "95.410" "29" "14" "24" "14" "546" "61.9" "6.52" "96.93" "14" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "Other interleukin signaling" "" "1" "0" "1.011" "0.857" "1.042" "1.024" "0.845" "0.998" "1.063" "0.901" "0.737" "881.6" "891.6" "755.3" "918.6" "902.8" "745.1" "879.6" "936.9" "794.6" "649.7" "" "" "" "" "" "" "" "" "" "" "795.8" "687.7" "584.2" "618.6" "753.1" "635.9" "746.1" "678.0" "535.9" "649.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "240711896831941506" "False" "High" "IsMasterProtein" "P23396" "Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "0.000" "False" "95.372" "55" "14" "44" "14" "243" "26.7" "9.66" "137.73" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.956" "1.013" "0.980" "1.037" "0.999" "1.018" "0.972" "0.987" "0.612" "2673.2" "2556.5" "2707.4" "2619.5" "2771.6" "2671.3" "2720.3" "2599.0" "2639.7" "1637.2" "" "" "" "" "" "" "" "" "" "" "2413.0" "1972.0" "2094.0" "1764.0" "2311.9" "2280.0" "2307.6" "1880.9" "1780.4" "1637.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5165886701298417594" "False" "High" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "0.000" "False" "94.929" "23" "18" "34" "18" "793" "88.8" "5.22" "97.62" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.951" "1.195" "1.055" "0.972" "1.145" "0.954" "0.887" "1.146" "1.366" "1397.3" "1329.4" "1669.9" "1473.8" "1358.4" "1599.5" "1333.1" "1240.1" "1601.5" "1908.5" "" "" "" "" "" "" "" "" "" "" "1261.3" "1025.4" "1291.6" "992.5" "1133.1" "1365.2" "1130.9" "897.4" "1080.2" "1908.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8724268624419382152" "False" "High" "IsMasterProtein" "P50213" "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1" "0.000" "False" "94.804" "39" "14" "35" "14" "366" "39.6" "6.92" "110.28" "14" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3419" "ENSG00000166411" "IDH3A" "D3DW83; hsa:3419; P50213; Q9H3X0" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "5" "0" "0.997" "1.050" "1.114" "0.969" "1.007" "1.076" "1.083" "0.973" "0.650" "3252.5" "3241.9" "3416.7" "3624.2" "3152.3" "3276.5" "3498.1" "3524.0" "3163.8" "2113.9" "" "" "" "" "" "" "" "" "" "" "2935.9" "2500.6" "2642.6" "2440.5" "2629.5" "2796.5" "2967.4" "2550.3" "2134.0" "2113.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1679721907195940966" "False" "High" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "0.000" "False" "94.797" "27" "9" "36" "9" "369" "41.3" "5.27" "115.31" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.952" "1.043" "0.978" "0.917" "1.031" "0.971" "0.930" "1.008" "0.953" "1929.2" "1837.2" "2012.7" "1887.1" "1768.9" "1989.7" "1873.5" "1794.5" "1944.5" "1837.7" "" "" "" "" "" "" "" "" "" "" "1741.5" "1417.1" "1556.7" "1270.8" "1475.5" "1698.3" "1589.2" "1298.6" "1311.6" "1837.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8479889696518381262" "False" "High" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "0.000" "False" "94.756" "55" "10" "59" "9" "199" "22.4" "8.25" "176.41" "10" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "Platelet degranulation" "" "1" "2" "0.983" "0.933" "0.980" "1.009" "0.960" "1.026" "1.076" "0.978" "0.940" "2327.6" "2287.4" "2171.0" "2280.8" "2347.4" "2235.3" "2388.3" "2503.8" "2276.9" "2188.0" "" "" "" "" "" "" "" "" "" "" "2101.0" "1764.4" "1679.1" "1535.9" "1958.2" "1907.8" "2025.9" "1812.0" "1535.8" "2188.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-719373628240286726" "False" "High" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "0.000" "False" "94.421" "36" "15" "25" "15" "422" "47.4" "6.48" "82.40" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "63" "0" "0.954" "0.738" "0.941" "0.984" "0.798" "0.991" "0.975" "0.775" "0.909" "1608.6" "1534.5" "1186.4" "1512.9" "1583.4" "1283.8" "1594.8" "1568.3" "1247.3" "1461.7" "" "" "" "" "" "" "" "" "" "" "1452.0" "1183.6" "917.6" "1018.8" "1320.8" "1095.7" "1352.9" "1134.9" "841.3" "1461.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193290723324093172" "False" "High" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "0.000" "False" "93.951" "37" "8" "59" "8" "252" "26.5" "9.36" "183.08" "8" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "" "Pyrimidine metabolism" "1" "0" "0.981" "1.074" "0.996" "0.971" "0.992" "0.991" "1.097" "1.010" "0.786" "1989.4" "1951.5" "2136.7" "1980.5" "1931.9" "1974.4" "1971.7" "2181.5" "2009.0" "1562.8" "" "" "" "" "" "" "" "" "" "" "1795.8" "1505.2" "1652.6" "1333.7" "1611.5" "1685.2" "1672.5" "1578.7" "1355.0" "1562.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015286030572761336" "False" "High" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "0.000" "False" "93.684" "28" "11" "28" "11" "427" "45.2" "8.85" "95.41" "11" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "7" "0" "1.029" "1.079" "1.051" "1.019" "1.005" "1.071" "1.008" "0.949" "0.846" "643.0" "661.6" "694.0" "675.7" "655.4" "646.1" "688.4" "647.9" "610.1" "544.1" "" "" "" "" "" "" "" "" "" "" "580.4" "510.3" "536.8" "455.0" "546.7" "551.5" "583.9" "468.9" "411.5" "544.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866201622056559647" "False" "High" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "0.000" "False" "93.358" "21" "16" "35" "16" "835" "88.5" "5.77" "106.15" "16" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "SUMOylation of transcription cofactors; Generic Transcription Pathway; HCMV Early Events" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "6" "0" "0.949" "0.876" "1.019" "0.999" "0.874" "1.053" "0.808" "0.833" "3.620" "1455.9" "1382.3" "1275.1" "1484.2" "1454.8" "1272.7" "1532.4" "1176.9" "1213.2" "5269.8" "" "" "" "" "" "" "" "" "" "" "1314.2" "1066.3" "986.2" "999.4" "1213.5" "1086.3" "1299.9" "851.7" "818.3" "5269.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1047543099056468626" "False" "High" "IsMasterProtein" "P09104" "Gamma-enolase OS=Homo sapiens OX=9606 GN=ENO2 PE=1 SV=3" "0.000" "False" "93.235" "37" "10" "35" "8" "434" "47.2" "5.03" "120.16" "10" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "2026" "ENSG00000111674" "ENO2" "B7Z2X9; hsa:2026; P09104; Q96J33" "Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "0" "1.135" "1.134" "1.153" "1.158" "1.267" "1.108" "1.148" "1.227" "0.873" "454.4" "515.6" "515.2" "524.1" "526.0" "575.8" "503.3" "521.8" "557.5" "396.6" "" "" "" "" "" "" "" "" "" "" "410.1" "397.7" "398.5" "352.9" "438.8" "491.5" "426.9" "377.6" "376.0" "396.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8621700409293052339" "False" "High" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "0.000" "False" "93.152" "22" "12" "47" "12" "584" "65.4" "7.61" "142.35" "12" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle in senescence" "3" "0" "1.038" "1.338" "1.082" "1.045" "1.338" "1.062" "1.045" "1.302" "0.925" "1568.8" "1629.2" "2098.5" "1697.1" "1638.8" "2099.5" "1666.3" "1639.8" "2042.7" "1450.9" "" "" "" "" "" "" "" "" "" "" "1416.2" "1256.6" "1623.0" "1142.8" "1367.1" "1791.9" "1413.5" "1186.7" "1377.8" "1450.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8120903851432865653" "False" "High" "IsMasterProtein" "P01889" "HLA class I histocompatibility antigen, B alpha chain OS=Homo sapiens OX=9606 GN=HLA-B PE=1 SV=3" "0.000" "False" "92.603" "32" "8" "28" "4" "362" "40.4" "5.85" "94.23" "8" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3106" "ENSG00000234745" "HLA-B" "A0A2I6Q7B5; B0V0B8; G3GN01; hsa:3106; O02862; O02956; O02957; O02960; O19555; O19556; O19595; O19615; O19624; O19625; O19627; O19641; O19651; O19675; O19692; O19758; O19779; O19783; O46702; O62897; O62901; O62915; O62917; O62919; O77933; O77959; O78053; O78138; O78160; O78163; O78172; O78173; O78180; O78217; O95730; O98140; P01889; P01890; P03989; P10317; P10318; P10319; P10320; P18463; P18464; P18465; P19373; P30460; P30461; P30462; P30463; P30464; P30465; P30466; P30467; P30468; P30469; P30470; P30471; P30472; P30473; P30474; P30475; P30476; P30477; P30478; P30479; P30480; P30481; P30482; P30483; P30484; P30485; P30486; P30487; P30488; P30489; P30490; P30491; P30492; P30493; P30494; P30495; P30496; P30497; P30498; P30513; P30685; P79489; P79490; P79496; P79504; P79523; P79524; P79542; P79555; Q04826; Q08136; Q29633; Q29636; Q29638; Q29661; Q29665; Q29678; Q29679; Q29681; Q29693; Q29695; Q29697; Q29718; Q29742; Q29749; Q29762; Q29764; Q29829; Q29836; Q29842; Q29845; Q29846; Q29847; Q29848; Q29850; Q29851; Q29852; Q29854; Q29855; Q29857; Q29858; Q29861; Q29924; Q29925; Q29933; Q29935; Q29936; Q29940; Q29953; Q29961; Q29982; Q30173; Q30198; Q31603; Q31610; Q31612; Q31613; Q546L8; Q546M4; Q5JP37; Q5QT24; Q5RIP1; Q5SRJ2; Q5TK76; Q5TK77; Q860I4; Q861B5; Q8HWF0; Q8MGQ3; Q8MHN4; Q8SNC5; Q95343; Q95344; Q95365; Q95369; Q95392; Q95HA3; Q95HA8; Q95HM9; Q95IA6; Q95IB8; Q95IH5; Q95J00; Q96IT9; Q9BCM6; Q9BCM7; Q9BCM8; Q9BD06; Q9BD38; Q9BD43; Q9GIL3; Q9GIM3; Q9GIX1; Q9GIY5; Q9GIZ0; Q9GIZ9; Q9GJ00; Q9GJ17; Q9GJ20; Q9GJ23; Q9GJ31; Q9GJF0; Q9GJM7; Q9MX21; Q9MY37; Q9MY42; Q9MY43; Q9MY61; Q9MY75; Q9MY78; Q9MY79; Q9MY84; Q9MY92; Q9MY93; Q9MY94; Q9MYB8; Q9MYC3; Q9MYC7; Q9MYF4; Q9MYG1; Q9TP35; Q9TP36; Q9TP37; Q9TP95; Q9TPQ7; Q9TPQ9; Q9TPR2; Q9TPR4; Q9TPS6; Q9TPT2; Q9TPT4; Q9TPT6; Q9TPV2; Q9TQG1; Q9TQH3; Q9TQH6; Q9TQH7; Q9TQH8; Q9TQH9; Q9TQM2; Q9TQN4; Q9TQN6; Q9UQS8; Q9UQT0" "DAP12 interactions; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome; Type II interferon signaling" "14" "4" "1.028" "0.806" "1.007" "0.967" "0.806" "0.980" "1.068" "0.770" "0.506" "1456.8" "1497.3" "1174.3" "1466.6" "1408.8" "1174.2" "1427.1" "1555.3" "1121.5" "736.8" "" "" "" "" "" "" "" "" "" "" "1315.0" "1154.9" "908.2" "987.6" "1175.2" "1002.2" "1210.6" "1125.6" "756.4" "736.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299836175419688438" "False" "High" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "0.000" "False" "92.588" "20" "12" "21" "12" "694" "75.4" "7.66" "79.35" "12" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "2" "0" "1.089" "1.556" "1.154" "1.069" "1.520" "1.103" "1.049" "1.576" "1.550" "707.9" "770.7" "1101.8" "817.1" "756.9" "1076.0" "780.9" "742.3" "1115.8" "1096.9" "" "" "" "" "" "" "" "" "" "" "639.0" "594.5" "852.2" "550.2" "631.4" "918.4" "662.4" "537.2" "752.6" "1096.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5272993671693515484" "False" "High" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "0.000" "False" "92.492" "52" "12" "38" "11" "289" "32.6" "5.86" "115.33" "12" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "" "2" "1" "0.974" "0.970" "0.890" "0.980" "1.019" "0.983" "1.008" "0.906" "0.747" "1507.0" "1468.2" "1461.1" "1341.9" "1477.2" "1535.1" "1480.9" "1518.5" "1365.1" "1126.0" "" "" "" "" "" "" "" "" "" "" "1360.3" "1132.5" "1130.1" "903.6" "1232.2" "1310.3" "1256.2" "1098.9" "920.7" "1126.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269209104434095274" "False" "High" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "0.000" "False" "92.444" "23" "13" "50" "13" "531" "58.0" "6.68" "152.97" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "16p11.2 proximal deletion syndrome" "7" "0" "1.019" "0.993" "1.015" "0.999" "0.964" "0.979" "1.064" "0.993" "0.761" "3134.2" "3195.2" "3111.6" "3180.4" "3129.6" "3020.5" "3069.5" "3335.0" "3111.0" "2386.4" "" "" "" "" "" "" "" "" "" "" "2829.1" "2464.6" "2406.6" "2141.7" "2610.6" "2578.0" "2603.8" "2413.5" "2098.3" "2386.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-990721738298047914" "False" "High" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "0.000" "False" "92.413" "59" "10" "31" "10" "241" "26.9" "5.17" "114.25" "10" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.073" "0.961" "1.066" "1.005" "1.054" "1.065" "1.110" "0.956" "0.890" "1043.8" "1119.9" "1003.1" "1112.5" "1048.7" "1100.2" "1111.2" "1158.2" "998.1" "928.9" "" "" "" "" "" "" "" "" "" "" "942.2" "863.8" "775.8" "749.1" "874.8" "939.0" "942.6" "838.2" "673.2" "928.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-515522588376759980" "False" "High" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "0.000" "False" "92.180" "30" "16" "32" "10" "623" "69.6" "8.59" "111.59" "16" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "5" "1.030" "1.099" "1.045" "1.088" "1.081" "1.051" "0.971" "1.090" "1.504" "2150.6" "2215.6" "2364.0" "2248.2" "2340.2" "2325.5" "2259.6" "2087.6" "2344.7" "3233.7" "" "" "" "" "" "" "" "" "" "" "1941.3" "1709.0" "1828.4" "1514.0" "1952.1" "1984.9" "1916.8" "1510.8" "1581.5" "3233.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462391840116260305" "False" "High" "IsMasterProtein" "Q05086" "Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4" "0.000" "False" "92.106" "16" "13" "21" "13" "875" "100.6" "5.22" "73.94" "13" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00632, Pf16558" "7337" "ENSG00000114062" "UBE3A" "A8K8Z9; hsa:7337; P78355; Q05086; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9" "Antigen processing: Ubiquitination & Proteasome degradation" "Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder" "5" "0" "1.072" "0.860" "1.021" "0.980" "0.883" "1.031" "1.010" "0.898" "0.836" "944.1" "1012.2" "812.3" "963.8" "925.2" "833.9" "973.1" "953.9" "847.6" "789.6" "" "" "" "" "" "" "" "" "" "" "852.3" "780.7" "628.3" "649.0" "771.8" "711.7" "825.5" "690.3" "571.7" "789.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6148920523022948324" "False" "High" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "0.000" "False" "92.095" "22" "18" "28" "18" "906" "102.4" "5.27" "84.94" "18" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.031" "0.920" "1.000" "0.998" "0.974" "0.987" "0.996" "0.894" "0.929" "1203.2" "1241.0" "1107.4" "1203.5" "1200.9" "1171.7" "1187.7" "1198.7" "1075.5" "1117.6" "" "" "" "" "" "" "" "" "" "" "1086.1" "957.3" "856.5" "810.4" "1001.7" "1000.0" "1007.5" "867.5" "725.4" "1117.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5335677543697524354" "False" "High" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "0.000" "False" "91.952" "26" "16" "29" "10" "614" "69.1" "8.92" "96.30" "16" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "mRNA Splicing - Major Pathway; SUMOylation of transcription cofactors; Estrogen-dependent gene expression; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "Ciliary landscape" "6" "0" "0.928" "0.678" "0.922" "0.947" "0.758" "1.003" "0.852" "0.731" "1.967" "723.7" "671.9" "490.5" "667.0" "685.5" "548.6" "726.1" "616.4" "529.2" "1423.5" "" "" "" "" "" "" "" "" "" "" "653.3" "518.2" "379.4" "449.1" "571.9" "468.2" "615.9" "446.1" "356.9" "1423.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-291186294764485320" "False" "High" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "0.000" "False" "91.550" "26" "18" "33" "18" "719" "81.3" "6.46" "104.46" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "12" "0" "1.046" "0.800" "0.987" "1.055" "0.856" "1.035" "1.049" "0.819" "0.943" "2340.9" "2447.9" "1873.4" "2311.0" "2469.3" "2004.8" "2421.8" "2456.1" "1918.0" "2208.1" "" "" "" "" "" "" "" "" "" "" "2113.1" "1888.2" "1448.9" "1556.2" "2059.8" "1711.1" "2054.4" "1777.4" "1293.7" "2208.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028691531671689044" "False" "High" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "0.000" "False" "91.547" "21" "18" "37" "18" "944" "106.8" "6.14" "115.04" "18" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802, Pf21365" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "N-glycan biosynthesis" "5" "0" "1.013" "1.037" "0.959" "1.005" "1.071" "0.985" "1.019" "1.021" "1.163" "2528.2" "2560.6" "2621.7" "2425.7" "2542.0" "2707.6" "2489.8" "2577.4" "2582.1" "2940.4" "" "" "" "" "" "" "" "" "" "" "2282.1" "1975.1" "2027.7" "1633.5" "2120.5" "2311.0" "2112.1" "1865.2" "1741.6" "2940.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100681429736934038" "False" "High" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "0.000" "False" "91.338" "36" "11" "26" "11" "330" "37.4" "10.01" "80.03" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "0.988" "0.876" "0.958" "0.989" "0.913" "0.980" "0.940" "0.833" "0.802" "1251.2" "1236.3" "1095.9" "1198.3" "1236.9" "1142.4" "1226.6" "1175.8" "1041.7" "1003.3" "" "" "" "" "" "" "" "" "" "" "1129.4" "953.6" "847.6" "806.9" "1031.8" "975.1" "1040.5" "850.9" "702.6" "1003.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312610725791659305" "False" "High" "IsMasterProtein" "P17812" "CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2" "0.000" "False" "91.317" "24" "15" "34" "15" "591" "66.6" "6.46" "120.76" "15" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "1503" "ENSG00000171793" "CTPS1" "B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "0.975" "0.832" "0.972" "0.953" "0.833" "0.993" "0.948" "0.828" "0.768" "2262.6" "2206.6" "1882.6" "2199.7" "2156.5" "1884.8" "2246.0" "2145.9" "1872.7" "1738.6" "" "" "" "" "" "" "" "" "" "" "2042.4" "1702.0" "1456.1" "1481.3" "1798.9" "1608.7" "1905.3" "1553.0" "1263.1" "1738.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1414691960117410819" "False" "High" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "0.000" "False" "91.213" "22" "17" "30" "17" "863" "96.5" "6.74" "91.87" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf21128" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "12" "0" "1.055" "0.757" "0.928" "1.008" "0.778" "1.036" "0.985" "0.728" "0.893" "1954.2" "2061.8" "1478.4" "1814.4" "1969.9" "1520.6" "2024.2" "1924.9" "1423.5" "1744.5" "" "" "" "" "" "" "" "" "" "" "1764.0" "1590.3" "1143.4" "1221.8" "1643.2" "1297.8" "1717.1" "1393.0" "960.2" "1744.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108024960006830899" "False" "High" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "0.000" "False" "91.193" "36" "12" "30" "12" "371" "42.4" "5.35" "91.81" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Estrogen-dependent gene expression; Extra-nuclear estrogen signaling; RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "11" "0" "1.010" "0.878" "0.935" "0.991" "1.025" "0.941" "0.986" "0.949" "0.813" "1475.6" "1490.3" "1295.2" "1379.8" "1462.8" "1512.4" "1388.7" "1455.2" "1400.6" "1199.1" "" "" "" "" "" "" "" "" "" "" "1332.0" "1149.6" "1001.8" "929.1" "1220.2" "1290.9" "1178.0" "1053.2" "944.7" "1199.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857660237806613264" "False" "High" "IsMasterProtein" "Q9NXV6" "CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3" "0.000" "False" "91.179" "32" "15" "24" "15" "580" "61.1" "9.01" "81.92" "15" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11952" "55602" "ENSG00000168564" "CDKN2AIP" "hsa:55602; Q8TBM5; Q9NXV6; Q9NYH0" "" "" "0" "0" "0.975" "0.979" "0.909" "1.020" "1.068" "0.937" "1.014" "1.020" "0.939" "1049.1" "1023.4" "1026.8" "954.1" "1070.2" "1120.5" "982.6" "1063.8" "1069.9" "985.5" "" "" "" "" "" "" "" "" "" "" "947.0" "789.4" "794.2" "642.5" "892.7" "956.4" "833.6" "769.9" "721.6" "985.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895528791649615838" "False" "High" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "0.000" "False" "90.988" "24" "11" "18" "11" "582" "63.8" "9.32" "67.35" "11" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "3" "0" "0.947" "1.563" "0.953" "0.935" "1.633" "0.951" "1.021" "1.597" "0.696" "1106.6" "1048.2" "1729.5" "1054.4" "1034.7" "1807.2" "1052.0" "1129.9" "1767.3" "770.1" "" "" "" "" "" "" "" "" "" "" "998.9" "808.6" "1337.6" "710.0" "863.1" "1542.4" "892.4" "817.7" "1192.0" "770.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5554010069989842743" "False" "High" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "0.000" "False" "90.851" "25" "11" "28" "11" "524" "59.0" "7.34" "86.41" "11" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "0.874" "0.873" "0.878" "0.850" "0.887" "0.829" "0.855" "0.902" "0.647" "1739.9" "1521.0" "1518.2" "1528.0" "1479.8" "1542.6" "1442.8" "1487.8" "1568.6" "1126.5" "" "" "" "" "" "" "" "" "" "" "1570.6" "1173.2" "1174.2" "1029.0" "1234.4" "1316.7" "1223.9" "1076.7" "1058.0" "1126.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2867565850229162791" "False" "High" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "0.000" "False" "90.419" "29" "18" "26" "14" "509" "57.4" "5.88" "87.96" "18" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Cytosolic tRNA aminoacylation" "Allograft rejection" "2" "4" "0.966" "0.986" "0.949" "1.044" "1.039" "0.993" "1.009" "1.008" "0.766" "1594.7" "1540.6" "1571.8" "1514.0" "1665.6" "1657.0" "1583.0" "1608.3" "1607.2" "1222.1" "" "" "" "" "" "" "" "" "" "" "1439.5" "1188.4" "1215.7" "1019.5" "1389.4" "1414.3" "1342.9" "1163.9" "1084.1" "1222.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936589147855356359" "False" "High" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "0.000" "False" "90.315" "22" "18" "35" "18" "795" "87.2" "7.12" "112.67" "18" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "Mitochondrial protein degradation" "Amino acid metabolism" "2" "0" "1.048" "0.803" "1.045" "1.038" "0.818" "1.043" "1.002" "0.891" "0.843" "2023.2" "2119.7" "1623.7" "2113.9" "2099.4" "1655.5" "2111.2" "2027.4" "1802.6" "1704.9" "" "" "" "" "" "" "" "" "" "" "1826.3" "1635.0" "1255.8" "1423.5" "1751.2" "1413.0" "1790.9" "1467.2" "1215.9" "1704.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6626039175338175676" "False" "High" "IsMasterProtein" "Q9NXH9" "tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1" "0.000" "False" "90.277" "27" "14" "24" "14" "659" "72.2" "7.64" "82.39" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf02005" "55621" "ENSG00000104907" "TRMT1" "hsa:55621; O76103; Q548Y5; Q8WVA6; Q9NXH9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.073" "0.975" "1.054" "1.049" "1.026" "1.071" "1.038" "0.956" "0.719" "730.0" "783.2" "711.5" "769.1" "765.4" "749.2" "782.0" "757.6" "697.7" "524.8" "" "" "" "" "" "" "" "" "" "" "658.9" "604.2" "550.3" "517.9" "638.5" "639.4" "663.3" "548.3" "470.6" "524.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305624722430213023" "False" "High" "IsMasterProtein" "Q9H4A3" "Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2" "0.000" "False" "90.175" "7" "18" "28" "18" "2382" "250.6" "6.34" "85.21" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf12202" "65125" "ENSG00000060237" "WNK1" "A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3; hsa:65125; O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; Q96CZ6; Q9H4A3; Q9P1S9" "Stimuli-sensing channels" "Ciliary landscape" "2" "0" "1.006" "0.967" "1.018" "0.966" "0.962" "1.048" "1.028" "0.899" "0.820" "1169.9" "1177.0" "1130.9" "1191.3" "1129.6" "1125.3" "1226.4" "1202.1" "1052.3" "959.3" "" "" "" "" "" "" "" "" "" "" "1056.0" "907.9" "874.6" "802.2" "942.3" "960.5" "1040.3" "869.9" "709.7" "959.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549742544018315320" "False" "High" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "0.000" "False" "90.114" "22" "14" "27" "14" "637" "72.6" "6.29" "91.01" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "5" "0" "0.998" "0.892" "0.974" "1.017" "0.937" "1.003" "1.032" "0.909" "0.711" "1897.6" "1893.2" "1692.8" "1848.1" "1929.9" "1778.6" "1903.6" "1959.2" "1725.1" "1350.0" "" "" "" "" "" "" "" "" "" "" "1712.9" "1460.3" "1309.3" "1244.5" "1609.8" "1518.1" "1614.8" "1417.9" "1163.6" "1350.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785579833791404998" "False" "High" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "0.000" "False" "90.107" "28" "11" "32" "11" "439" "49.2" "5.24" "92.40" "11" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Neutrophil degranulation; Asymmetric localization of PCP proteins; Degradation of DVL; ER-Phagosome pathway; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.008" "0.801" "0.972" "1.028" "0.811" "1.006" "0.991" "0.874" "0.739" "1494.0" "1506.2" "1196.5" "1451.6" "1536.2" "1211.2" "1503.7" "1481.2" "1305.8" "1103.9" "" "" "" "" "" "" "" "" "" "" "1348.6" "1161.8" "925.4" "977.5" "1281.4" "1033.8" "1275.5" "1072.0" "880.8" "1103.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877503792566385355" "False" "High" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "0.000" "False" "89.707" "43" "10" "30" "10" "258" "29.0" "4.83" "107.17" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.978" "1.011" "0.979" "0.925" "0.965" "1.000" "1.067" "0.972" "0.683" "2740.1" "2678.9" "2771.3" "2682.8" "2533.8" "2644.5" "2740.8" "2924.4" "2664.2" "1871.7" "" "" "" "" "" "" "" "" "" "" "2473.4" "2066.4" "2143.4" "1806.6" "2113.6" "2257.1" "2325.0" "2116.4" "1796.9" "1871.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7738217365816998519" "False" "High" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "0.000" "False" "89.285" "24" "17" "40" "17" "739" "83.1" "7.03" "123.57" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "HDAC6 interactions in the central nervous system" "3" "0" "1.028" "0.965" "1.051" "1.010" "0.965" "1.034" "1.005" "1.009" "0.735" "1903.3" "1955.8" "1836.1" "2001.0" "1921.6" "1836.4" "1968.1" "1913.4" "1919.7" "1399.5" "" "" "" "" "" "" "" "" "" "" "1718.1" "1508.6" "1420.1" "1347.5" "1603.0" "1567.4" "1669.5" "1384.7" "1294.8" "1399.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3607998631011874723" "False" "High" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "0.000" "False" "89.280" "25" "8" "33" "8" "328" "35.6" "7.39" "112.32" "8" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "1.052" "1.001" "1.052" "1.108" "1.069" "1.066" "1.060" "1.012" "0.712" "2233.0" "2350.2" "2234.9" "2348.0" "2474.8" "2386.7" "2379.8" "2367.2" "2259.5" "1590.5" "" "" "" "" "" "" "" "" "" "" "2015.6" "1812.8" "1728.5" "1581.2" "2064.4" "2037.1" "2018.7" "1713.1" "1524.0" "1590.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5870318523395655526" "False" "High" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "0.000" "False" "89.099" "37" "17" "31" "17" "514" "58.7" "6.43" "93.32" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "Cytosolic tRNA aminoacylation; Selenocysteine synthesis" "VEGFA-VEGFR2 signaling" "3" "0" "1.040" "0.937" "1.031" "1.030" "0.888" "1.063" "1.096" "0.976" "0.770" "1622.5" "1686.9" "1519.9" "1673.4" "1670.9" "1440.2" "1725.1" "1779.0" "1583.9" "1249.2" "" "" "" "" "" "" "" "" "" "" "1464.6" "1301.2" "1175.5" "1126.9" "1393.8" "1229.2" "1463.4" "1287.5" "1068.3" "1249.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2657182436335150623" "False" "High" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "0.000" "False" "88.893" "25" "12" "36" "12" "505" "55.2" "7.23" "105.30" "12" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "tRNA processing in the nucleus" "Unfolded protein response" "2" "0" "0.963" "1.021" "0.982" "0.959" "1.003" "0.963" "0.977" "0.998" "0.900" "2338.7" "2253.0" "2388.1" "2296.6" "2243.6" "2345.8" "2251.1" "2285.9" "2334.1" "2103.6" "" "" "" "" "" "" "" "" "" "" "2111.0" "1737.8" "1847.0" "1546.5" "1871.5" "2002.2" "1909.6" "1654.3" "1574.3" "2103.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7881821209807726399" "False" "High" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "0.000" "False" "88.458" "17" "20" "29" "20" "1309" "146.6" "6.13" "95.76" "20" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "" "Translation factors" "1" "0" "0.921" "0.877" "0.963" "0.929" "0.850" "0.928" "0.819" "0.829" "1.952" "1042.9" "960.0" "914.7" "1004.2" "969.0" "886.3" "967.3" "853.7" "864.2" "2035.5" "" "" "" "" "" "" "" "" "" "" "941.4" "740.5" "707.5" "676.2" "808.3" "756.5" "820.5" "617.8" "582.9" "2035.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3042753504910158627" "False" "High" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "0.000" "False" "88.237" "36" "10" "24" "10" "333" "35.1" "8.38" "78.69" "10" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "Respiratory electron transport" "" "1" "0" "0.967" "0.944" "0.931" "0.991" "0.971" "1.032" "0.977" "0.922" "0.697" "1287.9" "1245.3" "1216.2" "1199.6" "1275.7" "1250.2" "1329.6" "1258.1" "1186.8" "898.2" "" "" "" "" "" "" "" "" "" "" "1162.5" "960.5" "940.7" "807.8" "1064.2" "1067.0" "1127.9" "910.5" "800.5" "898.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2921825731244054349" "False" "High" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "0.000" "False" "87.646" "50" "9" "27" "9" "261" "26.9" "7.78" "88.25" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "8" "0" "1.061" "0.934" "1.075" "1.106" "1.008" "1.063" "1.040" "0.982" "0.757" "1273.4" "1350.8" "1189.6" "1369.2" "1408.8" "1284.0" "1353.2" "1324.7" "1250.2" "963.9" "" "" "" "" "" "" "" "" "" "" "1149.4" "1041.9" "920.1" "922.0" "1175.2" "1095.9" "1147.9" "958.7" "843.2" "963.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5089087001200962096" "False" "High" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0.000" "False" "87.341" "6" "12" "15" "12" "2813" "307.4" "5.24" "63.41" "12" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "8" "0" "1.002" "1.036" "1.117" "1.116" "1.205" "1.039" "0.983" "1.055" "1.364" "675.8" "677.3" "700.0" "754.6" "753.9" "814.4" "702.0" "664.6" "712.6" "921.5" "" "" "" "" "" "" "" "" "" "" "610.0" "522.4" "541.4" "508.1" "628.9" "695.1" "595.5" "481.0" "480.7" "921.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751284344252295029" "False" "High" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "0.000" "False" "87.087" "39" "10" "44" "10" "294" "32.6" "4.78" "146.18" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1-host interactions" "" "10" "0" "1.074" "1.096" "1.010" "1.004" "1.127" "0.959" "0.968" "1.132" "0.619" "1856.9" "1994.1" "2034.3" "1876.2" "1864.4" "2092.7" "1780.5" "1798.3" "2101.3" "1148.7" "" "" "" "" "" "" "" "" "" "" "1676.1" "1538.1" "1573.4" "1263.4" "1555.2" "1786.2" "1510.3" "1301.4" "1417.3" "1148.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506961570143965113" "False" "High" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "0.000" "False" "86.942" "50" "8" "53" "8" "189" "19.9" "6.79" "167.80" "8" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway; HDAC6 interactions in the central nervous system" "8" "0" "0.977" "1.046" "1.025" "1.005" "1.072" "0.993" "0.956" "1.084" "0.700" "2357.6" "2303.6" "2466.5" "2416.2" "2368.7" "2526.5" "2340.4" "2254.7" "2554.6" "1650.9" "" "" "" "" "" "" "" "" "" "" "2128.1" "1776.9" "1907.6" "1627.1" "1975.8" "2156.4" "1985.4" "1631.7" "1723.0" "1650.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823981804521467878" "False" "High" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "0.000" "False" "86.769" "9" "18" "22" "18" "3256" "358.5" "9.45" "66.16" "18" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "" "Primary focal segmental glomerulosclerosis (FSGS)" "1" "0" "0.982" "2.536" "1.059" "1.016" "2.461" "0.957" "0.994" "2.546" "1.175" "483.9" "475.3" "1227.4" "512.6" "491.8" "1190.8" "463.3" "481.2" "1231.9" "568.6" "" "" "" "" "" "" "" "" "" "" "436.8" "366.6" "949.3" "345.2" "410.3" "1016.4" "393.0" "348.3" "830.9" "568.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468069501493151827" "False" "High" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "0.000" "False" "86.763" "34" "11" "30" "11" "337" "37.5" "6.81" "98.57" "11" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "9" "0" "0.981" "1.005" "0.965" "0.949" "1.032" "0.980" "0.934" "1.017" "0.832" "2546.7" "2498.6" "2560.0" "2457.9" "2417.3" "2629.1" "2495.2" "2378.3" "2590.1" "2117.8" "" "" "" "" "" "" "" "" "" "" "2298.8" "1927.3" "1980.0" "1655.2" "2016.4" "2244.0" "2116.6" "1721.1" "1747.0" "2117.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7210504404319708374" "False" "High" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "0.000" "False" "86.677" "28" "13" "21" "7" "577" "60.9" "6.83" "63.75" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; tRNA processing in the nucleus; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "4" "1.036" "0.977" "1.068" "0.989" "0.981" "0.941" "0.967" "0.972" "0.776" "860.6" "891.2" "840.4" "919.3" "851.5" "844.0" "809.9" "832.1" "836.9" "667.6" "" "" "" "" "" "" "" "" "" "" "776.8" "687.4" "650.0" "619.1" "710.2" "720.4" "687.0" "602.2" "564.4" "667.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92619424180281671" "False" "High" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "0.000" "False" "86.449" "30" "11" "21" "5" "434" "49.7" "6.67" "65.96" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "" "2q37 copy number variation syndrome" "1" "7" "0.981" "1.017" "1.041" "0.937" "1.077" "0.903" "0.959" "1.076" "0.701" "1425.1" "1398.3" "1448.7" "1483.1" "1335.6" "1535.0" "1286.2" "1366.7" "1533.6" "999.0" "" "" "" "" "" "" "" "" "" "" "1286.4" "1078.6" "1120.5" "998.7" "1114.1" "1310.1" "1091.1" "989.0" "1034.4" "999.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5364611794781451874" "False" "High" "IsMasterProtein" "P08575" "Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3" "0.000" "False" "86.274" "11" "13" "22" "13" "1306" "147.4" "6.15" "80.17" "13" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00041, Pf00102, Pf12453, Pf12567" "5788" "ENSG00000081237; ENSG00000262418" "PTPRC" "A0A0A0MT22; A8K7W6; hsa:5788; P08575; Q16614; Q9H0Y6; X6R433" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Other semaphorin interactions" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulatory circuits of the STAT3 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; EPO receptor signaling; Interferon type I signaling pathways" "9" "0" "1.008" "0.998" "1.033" "1.004" "0.964" "1.042" "1.100" "1.018" "0.710" "798.3" "804.9" "796.9" "824.8" "801.8" "769.9" "832.2" "878.5" "812.7" "567.1" "" "" "" "" "" "" "" "" "" "" "720.6" "620.9" "616.4" "555.4" "668.8" "657.2" "705.9" "635.7" "548.2" "567.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666399162137355267" "False" "High" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "0.000" "False" "86.126" "51" "12" "35" "12" "255" "27.8" "8.10" "113.04" "12" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "Respiratory electron transport; Protein methylation" "" "2" "0" "0.991" "0.904" "1.030" "0.959" "0.890" "0.964" "0.955" "0.902" "0.661" "2063.7" "2045.2" "1866.0" "2126.2" "1978.5" "1836.7" "1989.4" "1970.4" "1861.1" "1363.4" "" "" "" "" "" "" "" "" "" "" "1862.8" "1577.6" "1443.3" "1431.8" "1650.4" "1567.6" "1687.6" "1426.0" "1255.3" "1363.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3038689840563559267" "False" "High" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "0.000" "False" "86.030" "16" "16" "30" "15" "1075" "113.3" "8.59" "101.18" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "" "16p11.2 distal deletion syndrome" "1" "1" "0.988" "1.000" "0.950" "1.018" "1.025" "1.004" "1.009" "0.958" "0.888" "2271.1" "2242.8" "2271.9" "2157.8" "2312.1" "2326.9" "2280.6" "2292.2" "2175.2" "2017.6" "" "" "" "" "" "" "" "" "" "" "2050.1" "1730.0" "1757.2" "1453.1" "1928.7" "1986.1" "1934.6" "1658.8" "1467.1" "2017.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7742249596596208262" "False" "High" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "0.000" "False" "85.848" "21" "17" "26" "17" "910" "101.9" "7.17" "87.20" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "Signaling by BRAF and RAF1 fusions" "VEGFA-VEGFR2 signaling" "2" "0" "1.011" "0.913" "1.051" "0.948" "0.915" "0.990" "0.621" "0.972" "6.983" "798.6" "807.7" "729.5" "839.0" "757.1" "731.0" "790.2" "495.8" "776.2" "5576.2" "" "" "" "" "" "" "" "" "" "" "720.9" "623.0" "564.2" "565.0" "631.6" "623.9" "670.3" "358.8" "523.6" "5576.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4945442823809026460" "False" "High" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "0.000" "False" "85.840" "32" "8" "18" "8" "308" "33.4" "5.69" "67.57" "8" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "Cytosolic sulfonation of small molecules" "" "1" "0" "0.968" "0.983" "1.132" "0.923" "1.036" "0.937" "0.940" "1.117" "0.735" "1536.0" "1486.6" "1510.5" "1739.3" "1417.1" "1591.3" "1439.4" "1443.0" "1715.3" "1128.6" "" "" "" "" "" "" "" "" "" "" "1386.5" "1146.7" "1168.2" "1171.2" "1182.1" "1358.2" "1221.0" "1044.3" "1157.0" "1128.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5506725299494211183" "False" "High" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "0.000" "False" "85.639" "52" "14" "36" "14" "263" "29.5" "6.61" "115.87" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "ER-Phagosome pathway; Ub-specific processing proteases; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.995" "1.036" "1.028" "0.969" "1.059" "0.961" "1.008" "1.055" "0.827" "1987.9" "1978.2" "2060.0" "2042.7" "1926.9" "2104.9" "1910.1" "2004.6" "2098.2" "1643.0" "" "" "" "" "" "" "" "" "" "" "1794.5" "1525.9" "1593.3" "1375.6" "1607.3" "1796.6" "1620.3" "1450.7" "1415.2" "1643.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8085176480319598229" "False" "High" "IsMasterProtein" "Q08188" "Protein-glutamine gamma-glutamyltransferase E OS=Homo sapiens OX=9606 GN=TGM3 PE=1 SV=4" "0.000" "False" "85.624" "24" "15" "28" "15" "693" "76.6" "5.86" "88.35" "15" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00868, Pf00927, Pf01841" "7053" "ENSG00000125780" "TGM3" "A8K5N6; B2RCR6; D3DVX1; O95933; Q08188; Q32ML9; Q32MM0" "" "" "0" "0" "1.012" "1.056" "1.089" "1.028" "1.175" "1.025" "1.036" "1.133" "0.726" "1071.4" "1084.0" "1131.3" "1166.6" "1101.5" "1258.9" "1098.7" "1110.5" "1213.5" "777.6" "" "" "" "" "" "" "" "" "" "" "967.1" "836.2" "875.0" "785.6" "918.9" "1074.5" "932.0" "803.6" "818.5" "777.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235259727744776076" "False" "High" "IsMasterProtein" "Q7Z4W1" "L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2" "0.000" "False" "85.542" "50" "10" "31" "10" "244" "25.9" "8.10" "106.48" "10" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13561" "51181" "ENSG00000169738" "DCXR" "hsa:51181; Q7Z4W1; Q9BTZ3; Q9UHY9" "Formation of xylulose-5-phosphate; Essential pentosuria" "" "2" "0" "1.023" "0.961" "1.094" "1.008" "1.040" "1.031" "1.054" "1.003" "0.710" "1005.4" "1028.1" "966.4" "1100.1" "1013.1" "1045.4" "1036.5" "1059.2" "1008.0" "713.4" "" "" "" "" "" "" "" "" "" "" "907.6" "793.0" "747.4" "740.8" "845.1" "892.2" "879.2" "766.6" "679.9" "713.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "419048109363271085" "False" "High" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "0.000" "False" "85.356" "26" "13" "30" "13" "525" "58.2" "6.92" "82.26" "13" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "Mitochondrial protein import; Mitochondrial protein degradation; Processing of SMDT1" "" "3" "0" "1.022" "0.999" "0.998" "1.037" "1.088" "0.997" "1.024" "1.053" "0.746" "1186.5" "1212.9" "1184.9" "1183.9" "1230.1" "1290.4" "1182.8" "1215.0" "1249.2" "885.4" "" "" "" "" "" "" "" "" "" "" "1071.1" "935.6" "916.5" "797.2" "1026.1" "1101.4" "1003.3" "879.3" "842.6" "885.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410325427073227732" "False" "High" "IsMasterProtein" "Cont_P68103" "Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1" "0.000" "True" "85.135" "24" "12" "109" "12" "462" "50.1" "9.01" "317.66" "12" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "100009189; 100137407; 100173928; 100415334; 100455760; 100583632; 100720380; 100860780; 100894850; 100978974; 101016039; 101102857; 101114018; 101120236; 101143481; 101427577; 101925273; 102283704; 102540473; 102729396; 102952660; 102986013; 103243896; 104657006; 104668174; 104669279; 104675330; 105064770; 105589208; 108529199; 108538073; 109248229; 109261840; 109563706; 1915; 282220; 403506; 493922; 494136; 574059; 716010" "ENSBGRG00000009070; ENSBIXG00000015018; ENSBIXG00005015547; ENSBMUG00000019814; ENSBTAG00000014534; ENSCABG00000013336; ENSCAFG00000002656; ENSCAFG00000054475; ENSCAFG00000056088; ENSCAFG00000057183; ENSCAFG00030004385; ENSCAFG00030013393; ENSCAFG00030013497; ENSCAFG00030026219; ENSCAFG00040018088; ENSCAFG00845012150; ENSCATG00000039727; ENSCCAG00000033087; ENSCHIG00000010087; ENSCJAG00000083200; ENSCPOG00000004067; ENSCSAG00000014041; ENSCWAG00000008166; ENSEASG00005004328; ENSEASG00005023174; ENSFCAG00000030977; ENSG00000156508; ENSGGOG00000025675; ENSLCNG00005010676; ENSMMUG00000004852; ENSNLEG00000035164; ENSOARG00000006149; ENSOARG00000007762; ENSOARG00000011616; ENSOCUG00000008481; ENSPANG00000006932; ENSPCTG00005022294; ENSPLOG00000016117; ENSPPAG00000038736; ENSPPYG00000016777; ENSPTEG00000025546; ENSPTIG00000007871; ENSPTRG00000018347; ENSRBIG00000028957; ENSRROG00000044652; ENSSSCG00005007871; ENSSSCG00015021824; ENSSSCG00035049336; ENSSSCG00060027448; ENSSSCG00065043427; ENSSSCG00070013256; ENSTGEG00000013204" "EEF1A; Eef1a1; EEF1A1; LOC102523342; LOC102540473; LOC105064770; LOC105879067; LOC111096123; LOC111152497; LOC112630422; LOC118356941; RABEFLA2" "A0A096NSJ4; A0A0D9RNJ1; A0A2I3HHP9; A0A2J8PVY3; A0A2J8RYS8; A0A2K5N7Z5; A0A2K5RPQ1; A0A2K6KG30; A0A2K6RQ54; A0A2R9BYN3; A0A2U3XB66; A0A2Y9F799; A0A2Y9HH84; A0A2Y9K0L0; A0A452E2H7; A0A485PKI5; A0A4W2G2H2; A0A4X1U102; A0A5N4BZH2; A0A663DJ63; A0A667H9L1; A0A6I9I937; A0A6J0YU90; A0A6J1ZA85; A0A6J3HMT0; A0A6P5CAS0; A0A6P6HZ37; A0A6P7EC07; A0A6P7EG13; A0A6P9FBB6; A0A811YU57; A0A8B7HCC5; A0A8B8RGI1; A0A8B9X6G1; A0A8C0H2M0; A0A8C0NJT4; A0A8C3W2U9; A0A8C4L5X9; A0A8C8XSK7; A0A8C9HVZ6; A0A8C9JCC1; A0A8D0I6I6; A0A8D2F6F8; A0A8D8FTM6; A0A8H2XW05; A0A8I3VX86; A0A8M1H472; A0A8U0UW05; A0A9L0JZA8; A0A9V1E3R7; A0A9W3GP67; A5PK01; A9X189; aju:106980206; B1MTF5; B7NZC3; biu:109563706; bom:102283704; bta:282220; C3PT41; caty:105589208; cfa:403506; cfr:102523342; chx:100860780; cjc:100415334; cjc:100894850; cpoc:100720380; csab:103243896; dnm:101427577; elk:111152497; F1RQG6; F2Z4P4; F6VFC8; F7AW94; fca:493922; G2HFA2; G3S518; ggo:101143481; H0V2B3; hsa:1915; L8I7U3; lww:102729396; mcc:716010; mcf:101925273; mmur:105879067; mpuf:101672541; nle:100583632; nsu:110583033; oas:101102857; oas:101114018; oas:101120236; ocu:100009189; P04719; P04720; P68103; P68104; P68105; panu:100137407; panu:101016039; pcad:102986013; pcoo:112862036; pon:100173928; pon:100455760; pps:100978974; ptg:102952660; ptr:494136; Q0PY11; Q2KJJ3; Q4R5K0; Q5NVF3; Q5R1X2; Q5R4R8; Q66RN5; Q6IPS9; Q6IQ15; rbb:108529199; rbb:108538073; rro:104657006; rro:104668174; rro:104669279; rro:104675330; ssc:574059; umr:103657393; vpc:102540473; W5PD15; zca:118356820; zca:118356941" "Neutrophil degranulation; Protein methylation; HSF1 activation; Eukaryotic Translation Elongation; Neutrophil degranulation; Neutrophil degranulation; Protein methylation; Eukaryotic Translation Elongation; HSF1 activation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; Peptide chain elongation; SARS-CoV-1 modulates host translation machinery" "Translation factors; EGFR1 signaling pathway; Fragile X syndrome; 2q37 copy number variation syndrome; EGFR1 signaling pathway" "20" "0" "0.981" "0.870" "0.899" "1.002" "0.902" "0.969" "1.012" "0.859" "0.787" "8409.0" "8250.6" "7316.7" "7558.1" "8426.1" "7587.5" "8148.6" "8510.9" "7219.2" "6618.6" "" "" "" "" "" "" "" "" "" "" "7590.6" "6364.1" "5659.0" "5089.6" "7028.7" "6476.0" "6912.3" "6159.2" "4869.2" "6618.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-453379581051164535" "False" "High" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "0.000" "False" "85.103" "49" "7" "33" "7" "187" "21.0" "7.53" "117.75" "7" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "9" "0" "0.953" "1.057" "0.992" "1.007" "1.112" "0.973" "1.010" "1.090" "0.686" "1556.8" "1483.5" "1645.5" "1543.9" "1568.0" "1730.7" "1514.5" "1572.5" "1696.3" "1068.7" "" "" "" "" "" "" "" "" "" "" "1405.3" "1144.3" "1272.7" "1039.7" "1308.0" "1477.2" "1284.7" "1138.0" "1144.1" "1068.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "454806171855366482" "False" "High" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "0.000" "False" "85.091" "16" "11" "20" "11" "763" "82.9" "9.04" "65.65" "11" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "13" "0" "1.000" "0.796" "0.887" "1.006" "0.804" "0.949" "0.924" "0.790" "1.702" "1288.8" "1289.4" "1026.3" "1143.1" "1296.3" "1036.4" "1222.9" "1191.5" "1018.7" "2193.4" "" "" "" "" "" "" "" "" "" "" "1163.4" "994.6" "793.8" "769.7" "1081.3" "884.6" "1037.4" "862.2" "687.1" "2193.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5836622772794954890" "False" "High" "IsMasterProtein" "P06400" "Retinoblastoma-associated protein OS=Homo sapiens OX=9606 GN=RB1 PE=1 SV=2" "0.000" "False" "85.037" "20" "19" "29" "19" "928" "106.1" "7.94" "92.86" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5925" "ENSG00000139687" "RB1" "A8K5E3; hsa:5925; P06400; P78499; Q5VW46; Q8IZL4" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Aberrant regulation of mitotic exit in cancer due to RB1 defects; RUNX2 regulates osteoblast differentiation; Condensation of Prophase Chromosomes; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Cyclin A:Cdk2-associated events at S phase entry; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Inhibition of replication initiation of damaged DNA by RB1/E2F1; Defective translocation of RB1 mutants to the nucleus; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; Nuclear events stimulated by ALK signaling in cancer" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Bladder cancer; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; Ciliary landscape; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sphingolipid metabolism in senescence; Prostaglandin and leukotriene metabolism in senescence ; ID signaling pathway; TROP2 regulatory signaling; Prostaglandin and leukotriene metabolism in senescence ; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; DNA damage response" "51" "0" "0.977" "0.670" "0.980" "0.963" "0.678" "1.032" "1.016" "0.682" "0.838" "2243.5" "2192.1" "1503.3" "2197.6" "2160.8" "1520.7" "2315.2" "2279.6" "1530.8" "1880.3" "" "" "" "" "" "" "" "" "" "" "2025.1" "1690.9" "1162.7" "1479.9" "1802.4" "1297.9" "1964.0" "1649.7" "1032.5" "1880.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574312361860662093" "False" "High" "IsMasterProtein" "Q92620" "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2" "0.000" "False" "84.883" "14" "16" "19" "16" "1227" "140.4" "6.54" "60.12" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9785" "ENSG00000140829" "DHX38" "B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "5" "0" "1.031" "0.918" "1.004" "0.987" "0.884" "1.029" "0.990" "0.928" "0.991" "608.4" "627.1" "558.6" "610.6" "600.4" "538.0" "625.8" "602.0" "564.8" "603.1" "" "" "" "" "" "" "" "" "" "" "549.2" "483.7" "432.0" "411.2" "500.8" "459.2" "530.8" "435.7" "380.9" "603.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1724337932377857957" "False" "High" "IsMasterProtein" "Q13619" "Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3" "0.000" "False" "84.605" "24" "18" "24" "11" "759" "87.6" "8.13" "75.09" "18" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8451" "ENSG00000139842" "CUL4A" "A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "0" "1.078" "1.042" "1.075" "1.014" "1.057" "1.005" "0.995" "1.083" "1.137" "682.1" "735.0" "710.9" "733.4" "691.8" "721.1" "685.2" "679.0" "738.7" "775.8" "" "" "" "" "" "" "" "" "" "" "615.7" "566.9" "549.8" "493.9" "577.1" "615.4" "581.3" "491.4" "498.2" "775.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137666002023082164" "False" "High" "IsMasterProtein" "Cont_P00761" "Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1" "0.000" "True" "84.478" "35" "6" "96" "6" "231" "24.4" "7.18" "301.73" "6" "protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "" "" "" "" "" "" "0" "0" "1.178" "1.703" "1.231" "1.536" "1.407" "1.560" "1.294" "1.517" "0.811" "3231.7" "3805.4" "5503.9" "3978.2" "4963.1" "4545.8" "5040.9" "4181.5" "4902.1" "2619.8" "" "" "" "" "" "" "" "" "" "" "2917.2" "2935.3" "4256.9" "2678.9" "4140.0" "3879.9" "4276.1" "3026.1" "3306.4" "2619.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4326632445175340721" "False" "High" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "0.000" "False" "84.353" "32" "7" "32" "6" "391" "45.3" "4.46" "103.81" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "2" "0" "1.052" "0.977" "1.003" "1.059" "1.085" "1.002" "1.039" "1.054" "1.073" "433.0" "455.6" "422.9" "434.4" "458.5" "470.0" "433.8" "450.0" "456.2" "464.6" "" "" "" "" "" "" "" "" "" "" "390.8" "351.4" "327.1" "292.5" "382.5" "401.2" "368.0" "325.7" "307.7" "464.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8220013005457955452" "False" "High" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "0.000" "False" "84.236" "17" "16" "29" "9" "915" "102.6" "5.47" "91.59" "16" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "SUMOylation of transcription cofactors" "Interleukin-1 (IL-1) structural pathway" "2" "5" "0.997" "1.744" "1.018" "1.051" "1.572" "0.992" "0.950" "1.682" "1.093" "1326.4" "1321.8" "2313.5" "1350.9" "1394.6" "2084.6" "1315.4" "1259.9" "2231.1" "1450.2" "" "" "" "" "" "" "" "" "" "" "1197.3" "1019.6" "1789.3" "909.7" "1163.3" "1779.2" "1115.8" "911.8" "1504.9" "1450.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896567990825277729" "False" "High" "IsMasterProtein" "O94925" "Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1" "0.000" "False" "84.104" "19" "10" "25" "10" "669" "73.4" "7.77" "86.47" "10" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf04960, Pf12796, Pf17959" "2744" "ENSG00000115419" "GLS" "hsa:2744; O94925; Q9UL05; Q9UL06; Q9UL07; Q9UN40" "Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells; Cell lineage map for neuronal differentiation" "8" "0" "0.976" "0.864" "1.007" "1.039" "0.877" "1.068" "1.065" "0.884" "0.875" "1330.4" "1299.1" "1149.1" "1339.7" "1382.1" "1167.0" "1421.5" "1416.9" "1175.6" "1163.8" "" "" "" "" "" "" "" "" "" "" "1201.0" "1002.0" "888.7" "902.2" "1152.9" "996.0" "1205.8" "1025.4" "792.9" "1163.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-478504765432675351" "False" "High" "IsMasterProtein" "P30520" "Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3" "0.000" "False" "83.933" "25" "10" "38" "10" "456" "50.1" "6.55" "106.62" "10" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00709" "159" "ENSG00000035687" "ADSS2" "B1AQM5; hsa:159; P30520; Q96EG7" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "1.001" "1.061" "1.045" "1.016" "1.088" "1.004" "1.005" "1.135" "0.722" "1294.8" "1296.0" "1373.5" "1353.1" "1315.6" "1408.5" "1300.6" "1300.7" "1469.8" "935.4" "" "" "" "" "" "" "" "" "" "" "1168.8" "999.6" "1062.3" "911.2" "1097.4" "1202.2" "1103.3" "941.3" "991.3" "935.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123184333862718981" "False" "High" "IsMasterProtein" "Q96BY6" "Dedicator of cytokinesis protein 10 OS=Homo sapiens OX=9606 GN=DOCK10 PE=1 SV=3" "0.000" "False" "83.891" "8" "17" "21" "17" "2186" "249.4" "7.14" "69.25" "17" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "55619" "ENSG00000135905" "DOCK10" "B3FL70; hsa:55619; O75178; Q68DA4; Q96BY6; Q9NW06; Q9NXI8" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "" "5" "0" "0.954" "0.811" "1.020" "0.994" "0.860" "1.006" "0.954" "0.880" "0.799" "853.8" "814.5" "692.1" "870.8" "848.2" "734.2" "858.9" "814.7" "751.0" "682.6" "" "" "" "" "" "" "" "" "" "" "770.7" "628.3" "535.3" "586.4" "707.6" "626.6" "728.6" "589.6" "506.5" "682.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6669951735420197648" "False" "High" "IsMasterProtein" "O00154" "Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3" "0.000" "False" "83.547" "31" "10" "28" "10" "380" "41.8" "8.54" "93.12" "10" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03061" "11332" "ENSG00000097021" "ACOT7" "A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; hsa:11332; O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "1.082" "1.065" "1.123" "1.110" "1.164" "1.132" "1.058" "1.150" "0.729" "816.6" "883.7" "869.8" "916.9" "906.5" "950.5" "924.3" "863.5" "938.9" "595.6" "" "" "" "" "" "" "" "" "" "" "737.1" "681.7" "672.8" "617.5" "756.2" "811.2" "784.1" "624.9" "633.3" "595.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "439747598683617185" "False" "High" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "0.000" "False" "83.522" "30" "11" "16" "11" "523" "57.5" "9.38" "54.13" "11" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Recycling of eIF2:GDP" "Translation factors; Primary ovarian insufficiency" "3" "0" "1.053" "0.891" "1.100" "1.091" "0.899" "1.007" "1.034" "0.928" "0.932" "513.9" "541.0" "457.9" "565.5" "560.9" "461.8" "517.6" "531.6" "476.8" "479.2" "" "" "" "" "" "" "" "" "" "" "463.9" "417.3" "354.1" "380.8" "467.9" "394.2" "439.1" "384.7" "321.6" "479.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2847148615950550488" "False" "High" "IsMasterProtein" "P20700" "Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2" "0.000" "False" "83.467" "22" "12" "22" "11" "586" "66.4" "5.16" "82.74" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf00932" "4001" "ENSG00000113368" "LMNB1" "B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6" "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Meiotic synapsis; RHOD GTPase cycle; RHOF GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "14" "0" "1.017" "2.665" "1.011" "0.985" "2.800" "1.024" "0.911" "2.500" "1.025" "480.8" "489.2" "1281.1" "485.8" "473.4" "1346.0" "492.2" "437.9" "1202.0" "493.0" "" "" "" "" "" "" "" "" "" "" "434.0" "377.3" "990.9" "327.2" "394.9" "1148.8" "417.5" "316.9" "810.7" "493.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010508153477037857" "False" "High" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "0.000" "False" "83.396" "29" "9" "37" "8" "355" "38.4" "7.81" "111.09" "9" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "1" "1.014" "1.031" "0.963" "0.986" "1.038" "0.977" "1.130" "0.971" "0.785" "2128.1" "2157.7" "2194.7" "2049.5" "2099.1" "2208.0" "2078.5" "2405.9" "2066.7" "1671.4" "" "" "" "" "" "" "" "" "" "" "1921.0" "1664.3" "1697.5" "1380.1" "1751.0" "1884.5" "1763.1" "1741.1" "1394.0" "1671.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3541019235990541605" "False" "High" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "0.000" "False" "83.375" "42" "17" "29" "17" "376" "42.9" "5.81" "88.78" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "0.944" "0.722" "0.924" "0.925" "0.766" "0.963" "0.974" "0.737" "0.844" "2465.1" "2326.6" "1780.9" "2277.0" "2279.5" "1888.2" "2372.9" "2401.5" "1817.1" "2081.4" "" "" "" "" "" "" "" "" "" "" "2225.2" "1794.6" "1377.4" "1533.3" "1901.5" "1611.6" "2012.9" "1738.0" "1225.6" "2081.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490484038664760531" "False" "High" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "0.000" "False" "83.352" "21" "7" "28" "7" "466" "52.1" "5.52" "98.58" "7" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "3" "0" "1.047" "1.247" "1.049" "1.100" "1.312" "1.029" "1.068" "1.314" "1.051" "1006.0" "1053.2" "1254.1" "1055.4" "1106.8" "1320.2" "1035.4" "1074.2" "1321.7" "1057.7" "" "" "" "" "" "" "" "" "" "" "908.1" "812.4" "969.9" "710.7" "923.3" "1126.8" "878.3" "777.4" "891.5" "1057.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4198310778640922638" "False" "High" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "0.000" "False" "83.201" "35" "10" "30" "10" "350" "38.4" "5.12" "102.93" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "Downregulation of TGF-beta receptor signaling" "TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer" "3" "0" "0.994" "1.067" "0.996" "1.032" "1.152" "0.983" "0.953" "1.119" "1.169" "1650.7" "1641.6" "1762.0" "1643.9" "1703.0" "1902.3" "1623.2" "1573.6" "1847.8" "1929.9" "" "" "" "" "" "" "" "" "" "" "1490.1" "1266.2" "1362.8" "1107.0" "1420.6" "1623.7" "1376.9" "1138.8" "1246.3" "1929.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1520164082407222722" "False" "High" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "0.000" "False" "82.895" "59" "7" "67" "4" "140" "15.0" "8.27" "189.19" "7" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "9" "5" "1.057" "1.072" "0.928" "1.022" "1.075" "0.982" "1.005" "1.063" "0.866" "2280.2" "2409.3" "2443.4" "2116.9" "2329.5" "2451.7" "2238.5" "2292.0" "2423.5" "1975.8" "" "" "" "" "" "" "" "" "" "" "2058.3" "1858.4" "1889.8" "1425.5" "1943.2" "2092.5" "1898.9" "1658.7" "1634.6" "1975.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220209801310809840" "False" "High" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "0.000" "False" "82.504" "41" "11" "23" "6" "318" "34.8" "6.98" "80.95" "11" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "4" "1.010" "0.909" "1.004" "0.988" "0.923" "0.952" "1.003" "0.855" "0.755" "786.1" "793.9" "714.6" "789.2" "776.5" "725.7" "748.6" "788.7" "672.3" "593.9" "" "" "" "" "" "" "" "" "" "" "709.6" "612.4" "552.7" "531.5" "647.8" "619.4" "635.0" "570.8" "453.5" "593.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1757040485264551221" "False" "High" "IsMasterProtein" "Q9Y6A5" "Transforming acidic coiled-coil-containing protein 3 OS=Homo sapiens OX=9606 GN=TACC3 PE=1 SV=1" "0.000" "False" "82.478" "18" "13" "20" "13" "838" "90.3" "5.05" "72.33" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf05010" "10460" "ENSG00000013810" "TACC3" "hsa:10460; Q2NKK4; Q3KQS5; Q9UMQ1; Q9Y6A5" "Negative regulation of NOTCH4 signaling; NOTCH3 Activation and Transmission of Signal to the Nucleus" "4p16.3 copy number variation" "3" "0" "1.091" "0.972" "1.071" "1.003" "0.938" "1.001" "0.980" "0.919" "0.862" "750.1" "818.2" "729.0" "803.7" "752.5" "703.6" "750.6" "734.9" "689.0" "646.3" "" "" "" "" "" "" "" "" "" "" "677.1" "631.1" "563.8" "541.2" "627.7" "600.5" "636.7" "531.8" "464.7" "646.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1619484696952214884" "False" "High" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "0.000" "False" "82.432" "40" "7" "32" "6" "225" "24.7" "4.67" "119.69" "7" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Eukaryotic Translation Elongation" "Translation factors" "2" "0" "0.922" "0.878" "0.921" "0.908" "0.919" "0.943" "0.939" "0.918" "1.294" "2002.6" "1846.2" "1758.0" "1845.1" "1818.5" "1840.9" "1888.5" "1879.5" "1838.3" "2591.0" "" "" "" "" "" "" "" "" "" "" "1807.7" "1424.0" "1359.7" "1242.5" "1517.0" "1571.2" "1602.0" "1360.2" "1239.9" "2591.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575182119282234217" "False" "High" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "0.000" "False" "82.382" "44" "9" "30" "9" "254" "28.8" "7.18" "105.66" "9" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "8" "0" "0.998" "1.067" "0.935" "1.007" "1.069" "0.985" "1.050" "0.998" "0.753" "1555.7" "1552.1" "1660.4" "1454.5" "1567.3" "1663.7" "1532.9" "1633.9" "1552.6" "1171.5" "" "" "" "" "" "" "" "" "" "" "1404.2" "1197.2" "1284.2" "979.4" "1307.4" "1420.0" "1300.3" "1182.4" "1047.2" "1171.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6096160842803463632" "False" "High" "IsMasterProtein" "Q9NQX3" "Gephyrin OS=Homo sapiens OX=9606 GN=GPHN PE=1 SV=1" "0.000" "False" "82.371" "22" "14" "24" "14" "736" "79.7" "5.43" "83.18" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00994, Pf03453, Pf03454" "10243" "ENSG00000171723" "GPHN" "hsa:10243; Q96KU4; Q9H4E9; Q9NQX3; Q9P2G2" "Molybdenum cofactor biosynthesis" "Splicing factor NOVA regulated synaptic proteins; GABA receptor signaling; Fragile X syndrome; Metabolic Epileptic Disorders; Cell lineage map for neuronal differentiation" "6" "0" "0.982" "0.897" "0.971" "0.981" "0.967" "0.950" "0.983" "0.919" "0.771" "1192.4" "1170.7" "1070.1" "1157.8" "1169.4" "1153.6" "1132.3" "1172.2" "1095.7" "919.2" "" "" "" "" "" "" "" "" "" "" "1076.4" "903.0" "827.7" "779.7" "975.5" "984.6" "960.5" "848.3" "739.0" "919.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088967002815659299" "False" "High" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "0.000" "False" "82.348" "32" "15" "34" "15" "437" "50.1" "6.67" "108.80" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "Translation factors" "3" "0" "0.940" "0.894" "0.982" "0.928" "0.825" "0.986" "0.907" "0.873" "1.261" "2493.5" "2343.5" "2228.3" "2448.0" "2312.9" "2057.4" "2459.3" "2261.2" "2177.4" "3143.3" "" "" "" "" "" "" "" "" "" "" "2250.8" "1807.7" "1723.5" "1648.5" "1929.4" "1756.0" "2086.2" "1636.4" "1468.6" "3143.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488092828150113306" "False" "High" "IsMasterProtein" "Q86UX7" "Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1" "0.000" "False" "82.270" "24" "14" "24" "14" "667" "75.9" "6.98" "69.74" "14" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf00373, Pf18124" "83706" "ENSG00000149781" "FERMT3" "hsa:83706; Q86UX7; Q8IUA1; Q8N207; Q9BT48" "Platelet degranulation" "Leukocyte-intrinsic Hippo pathway functions" "2" "0" "1.002" "0.769" "0.947" "0.992" "0.759" "0.995" "0.872" "0.813" "1.290" "679.8" "681.1" "522.9" "644.1" "674.4" "516.3" "676.7" "593.0" "552.7" "877.2" "" "" "" "" "" "" "" "" "" "" "613.7" "525.4" "404.4" "433.7" "562.5" "440.6" "574.0" "429.2" "372.8" "877.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-537602968940689111" "False" "High" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "0.000" "False" "82.109" "26" "15" "41" "15" "589" "65.3" "5.11" "126.11" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PKR-mediated signaling; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "50" "0" "0.981" "0.891" "0.994" "0.960" "0.885" "0.953" "0.975" "0.897" "0.791" "3425.9" "3360.6" "3051.1" "3404.4" "3287.3" "3032.6" "3263.7" "3339.8" "3072.5" "2710.7" "" "" "" "" "" "" "" "" "" "" "3092.5" "2592.2" "2359.8" "2292.5" "2742.1" "2588.4" "2768.5" "2417.0" "2072.4" "2710.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3370309329751245495" "False" "High" "IsMasterProtein" "Q96RQ9" "L-amino-acid oxidase OS=Homo sapiens OX=9606 GN=IL4I1 PE=1 SV=1" "0.000" "False" "82.023" "23" "12" "36" "12" "567" "62.8" "8.68" "98.97" "12" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01593" "259307" "ENSG00000104951" "IL4I1" "hsa:259307; Q1WMJ3; Q4GZN1; Q4GZN2; Q6P2Q3; Q8TEM5; Q96RQ8; Q96RQ9" "Phenylalanine metabolism" "Methionine de novo and salvage pathway" "2" "0" "1.028" "1.050" "1.038" "0.977" "1.065" "1.006" "0.918" "1.094" "0.793" "942.4" "969.1" "989.2" "977.7" "920.9" "1003.2" "948.3" "865.0" "1031.3" "747.6" "" "" "" "" "" "" "" "" "" "" "850.6" "747.5" "765.1" "658.4" "768.1" "856.2" "804.4" "626.0" "695.6" "747.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7688952667704275831" "False" "High" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "0.000" "False" "81.853" "44" "10" "31" "10" "248" "27.9" "8.46" "99.54" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "1.012" "1.083" "1.037" "1.027" "1.177" "0.999" "0.993" "1.150" "0.844" "1454.7" "1472.9" "1574.9" "1508.2" "1494.6" "1712.6" "1452.7" "1444.5" "1673.3" "1228.2" "" "" "" "" "" "" "" "" "" "" "1313.1" "1136.1" "1218.1" "1015.6" "1246.7" "1461.7" "1232.3" "1045.4" "1128.7" "1228.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589685267009723312" "False" "High" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "0.000" "False" "81.439" "18" "15" "31" "15" "950" "108.5" "7.47" "107.01" "15" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "mRNA processing" "3" "0" "1.027" "1.146" "1.005" "1.019" "1.200" "1.002" "1.004" "1.180" "0.915" "1973.0" "2026.2" "2261.5" "1981.9" "2011.3" "2367.9" "1976.0" "1979.9" "2328.3" "1805.2" "" "" "" "" "" "" "" "" "" "" "1780.9" "1562.9" "1749.1" "1334.6" "1677.7" "2021.0" "1676.2" "1432.8" "1570.4" "1805.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3579121838691215902" "False" "High" "IsMasterProtein" "Q7Z6I6" "Rho GTPase-activating protein 30 OS=Homo sapiens OX=9606 GN=ARHGAP30 PE=1 SV=3" "0.000" "False" "81.390" "16" "14" "16" "14" "1101" "118.5" "4.81" "55.33" "14" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "257106" "ENSG00000186517" "ARHGAP30" "hsa:257106; Q5SY52; Q5SY53; Q5SY54; Q6ZML6; Q7Z3J8; Q7Z6I6; Q86XI7" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle" "" "4" "0" "1.047" "1.518" "1.034" "1.082" "1.514" "1.089" "1.042" "1.430" "1.279" "549.8" "575.7" "834.8" "568.6" "595.2" "832.7" "598.9" "572.9" "786.2" "703.2" "" "" "" "" "" "" "" "" "" "" "496.3" "444.0" "645.7" "382.9" "496.5" "710.7" "508.0" "414.6" "530.3" "703.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3968134916858178565" "False" "High" "IsMasterProtein" "P61247" "Small ribosomal subunit protein eS1 OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "0.000" "False" "81.049" "54" "14" "35" "14" "264" "29.9" "9.73" "115.13" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425; ENSG00000292158" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.960" "1.024" "0.974" "1.053" "1.036" "1.047" "1.037" "0.988" "0.648" "2045.6" "1962.7" "2094.9" "1992.6" "2153.0" "2118.9" "2141.7" "2122.1" "2020.2" "1325.8" "" "" "" "" "" "" "" "" "" "" "1846.5" "1513.9" "1620.3" "1341.8" "1795.9" "1808.5" "1816.7" "1535.7" "1362.6" "1325.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7644877244443849971" "False" "High" "IsMasterProtein" "Q13177" "Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3" "0.000" "False" "81.018" "24" "12" "24" "10" "524" "58.0" "5.96" "73.67" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5062" "ENSG00000180370" "PAK2" "hsa:5062; Q13154; Q13177; Q6ISC3" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; FCERI mediated MAPK activation; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; RHOU GTPase cycle; RHOV GTPase cycle; Smooth Muscle Contraction; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Ephrin signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Nef and signal transduction; Stimulation of the cell death response by PAK-2p34" "Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway" "45" "1" "0.984" "0.780" "0.968" "0.995" "0.829" "0.977" "0.957" "0.834" "0.669" "1148.4" "1130.1" "896.1" "1112.0" "1142.2" "952.2" "1121.9" "1099.6" "958.3" "767.8" "" "" "" "" "" "" "" "" "" "" "1036.7" "871.7" "693.1" "748.9" "952.8" "812.7" "951.7" "795.7" "646.4" "767.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8048199414682788645" "False" "High" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "0.000" "False" "80.847" "42" "10" "30" "10" "249" "28.7" "6.02" "104.77" "10" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "0.969" "0.953" "0.982" "0.964" "1.008" "1.021" "1.093" "0.912" "0.642" "1901.6" "1842.0" "1812.1" "1867.8" "1833.9" "1916.3" "1941.6" "2078.3" "1734.2" "1220.2" "" "" "" "" "" "" "" "" "" "" "1716.5" "1420.8" "1401.5" "1257.8" "1529.8" "1635.6" "1647.0" "1504.0" "1169.7" "1220.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4900440247780228765" "False" "High" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "0.000" "False" "80.684" "22" "18" "24" "18" "776" "89.6" "8.00" "73.74" "18" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Circadian Clock; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Pleural mesothelioma; Notch signaling pathway" "41" "0" "0.994" "1.036" "0.983" "1.022" "1.055" "0.989" "1.006" "1.047" "0.857" "980.4" "974.1" "1015.7" "964.2" "1002.5" "1034.1" "969.4" "986.0" "1026.2" "839.9" "" "" "" "" "" "" "" "" "" "" "885.0" "751.4" "785.6" "649.3" "836.2" "882.7" "822.3" "713.6" "692.1" "839.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887047081584333281" "False" "High" "IsMasterProtein" "P54652" "Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1" "0.000" "False" "80.465" "16" "10" "54" "1" "639" "70.0" "5.74" "175.73" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "3306" "ENSG00000126803" "HSPA2" "hsa:3306; P54652; Q15508; Q53XM3; Q9UE78" "Regulation of HSF1-mediated heat shock response; PKR-mediated signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Meiotic synapsis; Attenuation phase" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection; 7q11.23 copy number variation syndrome; Urotensin-II-mediated signaling pathway" "10" "0" "0.697" "0.865" "0.686" "0.776" "0.799" "0.804" "0.784" "0.801" "0.812" "147.2" "102.6" "127.3" "101.0" "114.2" "117.6" "118.3" "115.4" "117.9" "119.5" "" "" "" "" "" "" "" "" "" "" "132.9" "79.1" "98.5" "68.0" "95.2" "100.4" "100.4" "83.5" "79.5" "119.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8024352083789976777" "False" "High" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "0.000" "False" "80.296" "12" "17" "23" "16" "1341" "151.8" "6.43" "78.92" "17" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "" "2" "1" "1.026" "1.489" "0.986" "1.046" "1.510" "1.052" "1.033" "1.492" "0.927" "1245.2" "1277.5" "1853.8" "1227.5" "1302.2" "1880.5" "1309.6" "1286.3" "1857.7" "1154.5" "" "" "" "" "" "" "" "" "" "" "1124.0" "985.4" "1433.8" "826.6" "1086.2" "1605.0" "1110.9" "930.9" "1253.0" "1154.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "114843226561293462" "False" "High" "IsMasterProtein" "P67936" "Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3" "0.000" "False" "79.841" "56" "14" "55" "8" "248" "28.5" "4.69" "178.82" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7171" "ENSG00000167460" "TPM4" "hsa:7171; P07226; P67936; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4" "Signaling by ALK fusions and activated point mutants; RHOV GTPase cycle; Smooth Muscle Contraction; Striated Muscle Contraction" "Striated muscle contraction pathway" "5" "3" "1.000" "1.014" "1.181" "0.963" "0.933" "1.026" "1.106" "1.049" "0.720" "2180.7" "2179.7" "2211.2" "2576.1" "2100.4" "2033.8" "2238.5" "2411.5" "2288.4" "1570.3" "" "" "" "" "" "" "" "" "" "" "1968.5" "1681.3" "1710.2" "1734.7" "1752.0" "1735.8" "1898.9" "1745.2" "1543.5" "1570.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8717421015690566095" "False" "High" "IsMasterProtein" "Q9NQR4" "Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1" "0.000" "False" "79.131" "48" "12" "27" "12" "276" "30.6" "7.21" "92.01" "12" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00795" "56954" "ENSG00000114021" "NIT2" "B2R9A3; D3DN47; hsa:56954; Q8WUF0; Q9NQR4" "Neutrophil degranulation" "" "1" "0" "0.990" "1.113" "0.948" "0.999" "1.153" "0.986" "0.994" "1.125" "0.734" "1314.9" "1302.0" "1463.8" "1246.2" "1313.7" "1516.1" "1296.4" "1306.9" "1478.7" "965.6" "" "" "" "" "" "" "" "" "" "" "1186.9" "1004.3" "1132.2" "839.2" "1095.8" "1294.0" "1099.7" "945.8" "997.3" "965.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6939588679820243468" "False" "High" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "0.000" "False" "79.038" "33" "10" "20" "10" "301" "33.9" "8.38" "73.58" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "15" "0" "1.037" "0.911" "0.987" "1.043" "1.020" "0.963" "1.042" "0.951" "0.786" "1299.8" "1348.5" "1183.8" "1282.6" "1355.3" "1325.5" "1252.3" "1354.0" "1236.3" "1021.5" "" "" "" "" "" "" "" "" "" "" "1173.3" "1040.1" "915.6" "863.7" "1130.6" "1131.3" "1062.3" "979.9" "833.9" "1021.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101173507286650100" "False" "High" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "0.000" "False" "79.027" "42" "11" "24" "11" "315" "37.1" "4.64" "80.68" "11" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13202" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "5" "0" "0.978" "1.000" "0.954" "0.865" "0.957" "0.985" "1.015" "0.940" "0.717" "1515.0" "1481.8" "1514.2" "1444.5" "1310.5" "1449.9" "1492.8" "1538.1" "1424.7" "1085.9" "" "" "" "" "" "" "" "" "" "" "1367.5" "1143.0" "1171.2" "972.8" "1093.2" "1237.5" "1266.3" "1113.1" "961.0" "1085.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904029165854268952" "False" "High" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "0.000" "False" "78.882" "41" "17" "31" "16" "440" "49.2" "6.21" "88.99" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.028" "0.713" "0.929" "0.972" "0.748" "0.987" "1.007" "0.708" "0.869" "1815.2" "1866.3" "1294.6" "1686.5" "1764.2" "1358.3" "1791.1" "1828.0" "1284.5" "1577.5" "" "" "" "" "" "" "" "" "" "" "1638.5" "1439.6" "1001.3" "1135.7" "1471.6" "1159.4" "1519.4" "1322.9" "866.4" "1577.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1873273852874603797" "False" "High" "IsMasterProtein" "Q709C8" "Intermembrane lipid transfer protein VPS13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1" "0.000" "False" "78.797" "6" "18" "20" "18" "3753" "422.1" "6.83" "63.63" "18" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "54832" "ENSG00000129003" "VPS13C" "hsa:54832; Q6ISR4; Q702P2; Q702P3; Q709C8; Q709C9; Q9NXN8; Q9P2C6" "" "" "0" "0" "1.033" "0.962" "1.072" "1.030" "0.924" "1.008" "0.999" "0.983" "0.956" "1108.6" "1145.7" "1066.4" "1188.6" "1142.4" "1024.6" "1117.2" "1107.2" "1090.2" "1059.6" "" "" "" "" "" "" "" "" "" "" "1000.7" "883.7" "824.8" "800.4" "952.9" "874.5" "947.7" "801.3" "735.3" "1059.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1853475733980272119" "False" "High" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "0.000" "False" "78.690" "19" "15" "28" "10" "780" "85.0" "7.50" "90.32" "15" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Neutrophil degranulation; Glycolysis" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "9" "0" "1.005" "0.974" "1.051" "0.973" "0.881" "1.014" "1.016" "0.976" "0.768" "418.7" "421.0" "407.8" "439.9" "407.3" "369.0" "424.6" "425.3" "408.6" "321.7" "" "" "" "" "" "" "" "" "" "" "378.0" "324.7" "315.4" "296.3" "339.7" "314.9" "360.2" "307.8" "275.6" "321.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951923410761951319" "False" "High" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "0.000" "False" "78.621" "31" "11" "26" "11" "394" "43.8" "6.55" "85.93" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "Neutrophil degranulation" "" "1" "0" "0.989" "1.297" "1.061" "1.117" "1.459" "1.098" "1.007" "1.360" "0.925" "1375.4" "1360.3" "1783.4" "1459.1" "1536.9" "2006.8" "1510.8" "1385.7" "1870.3" "1272.1" "" "" "" "" "" "" "" "" "" "" "1241.5" "1049.2" "1379.3" "982.5" "1282.0" "1712.8" "1281.6" "1002.8" "1261.5" "1272.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-951770295276680131" "False" "High" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "0.000" "False" "78.615" "13" "12" "17" "12" "1014" "113.0" "8.88" "58.74" "12" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063, Pf21728" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "SUMOylation of DNA damage response and repair proteins; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map" "25" "0" "0.959" "2.126" "1.023" "1.043" "2.286" "0.995" "0.551" "2.245" "8.290" "569.7" "546.5" "1211.2" "582.7" "593.9" "1302.3" "567.0" "314.2" "1279.1" "4722.6" "" "" "" "" "" "" "" "" "" "" "514.2" "421.6" "936.8" "392.4" "495.4" "1111.6" "481.0" "227.4" "862.8" "4722.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "250780751349012114" "False" "High" "IsMasterProtein" "Cont_Q29443" "Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1" "0.000" "True" "78.404" "26" "16" "22" "16" "704" "77.7" "7.08" "67.36" "16" "stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00405" "280705" "" "TF" "bta:280705; Q0IIK2; Q29443" "" "" "0" "0" "1.195" "1.234" "1.072" "1.095" "1.545" "1.051" "1.014" "1.700" "0.909" "1145.0" "1368.7" "1412.9" "1227.2" "1254.1" "1769.3" "1203.9" "1160.7" "1946.8" "1040.5" "" "" "" "" "" "" "" "" "" "" "1033.5" "1055.7" "1092.8" "826.4" "1046.1" "1510.1" "1021.2" "840.0" "1313.1" "1040.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472410284542291541" "False" "High" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "0.000" "False" "78.377" "45" "11" "31" "11" "254" "29.5" "5.95" "102.98" "11" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Regulation of expression of SLITs and ROBOs; ER-Phagosome pathway; Degradation of beta-catenin by the destruction complex; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling" "Proteasome degradation" "60" "0" "0.959" "0.845" "0.963" "0.953" "0.875" "0.962" "0.982" "0.848" "0.684" "1458.4" "1399.3" "1232.5" "1405.0" "1389.9" "1276.0" "1403.0" "1432.2" "1236.4" "997.2" "" "" "" "" "" "" "" "" "" "" "1316.5" "1079.3" "953.2" "946.1" "1159.4" "1089.1" "1190.1" "1036.5" "833.9" "997.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836075231128367811" "False" "High" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "0.000" "False" "78.273" "34" "15" "31" "15" "389" "45.5" "5.62" "102.69" "15" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602, Pf21154" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "Neutrophil degranulation; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "0.981" "0.774" "0.984" "0.975" "0.801" "0.989" "0.990" "0.785" "0.880" "2277.7" "2235.5" "1762.6" "2242.1" "2221.3" "1823.8" "2253.2" "2255.8" "1788.5" "2004.3" "" "" "" "" "" "" "" "" "" "" "2056.1" "1724.4" "1363.3" "1509.8" "1852.9" "1556.6" "1911.3" "1632.5" "1206.3" "2004.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8832352295829315313" "False" "High" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "0.000" "False" "78.100" "23" "11" "29" "11" "509" "54.1" "7.85" "79.26" "11" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Mitochondrial protein degradation; Glycine degradation" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)" "19" "0" "1.035" "1.200" "0.952" "1.021" "1.205" "1.041" "1.023" "1.154" "0.720" "2457.7" "2543.1" "2948.9" "2339.9" "2508.9" "2962.5" "2558.6" "2514.9" "2837.1" "1768.7" "" "" "" "" "" "" "" "" "" "" "2218.5" "1961.6" "2280.8" "1575.7" "2092.8" "2528.6" "2170.4" "1820.0" "1913.6" "1768.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1728322554936911435" "False" "High" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "0.000" "False" "77.840" "22" "14" "18" "14" "699" "73.6" "9.47" "64.86" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "1.056" "1.876" "1.014" "1.084" "1.754" "1.013" "0.945" "1.731" "1.014" "1318.0" "1392.2" "2473.1" "1336.8" "1428.6" "2311.8" "1335.4" "1245.5" "2281.0" "1336.4" "" "" "" "" "" "" "" "" "" "" "1189.7" "1073.8" "1912.8" "900.2" "1191.7" "1973.2" "1132.8" "901.4" "1538.5" "1336.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7946497630754715310" "False" "High" "IsMasterProtein" "Q9H223" "EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1" "0.000" "False" "77.740" "23" "12" "20" "10" "541" "61.1" "6.76" "61.44" "12" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30844" "ENSG00000103966" "EHD4" "hsa:30844; Q9H223; Q9HAR1; Q9NZN2" "" "" "0" "2" "0.987" "0.753" "1.003" "1.002" "0.757" "1.028" "0.951" "0.765" "0.888" "1250.3" "1233.8" "940.9" "1253.4" "1252.3" "946.5" "1285.2" "1189.1" "956.4" "1109.9" "" "" "" "" "" "" "" "" "" "" "1128.6" "951.7" "727.7" "844.1" "1044.6" "807.8" "1090.2" "860.6" "645.1" "1109.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637669709604963095" "False" "High" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "0.000" "False" "77.682" "11" "15" "19" "15" "1972" "213.4" "4.70" "59.74" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); SUMOylation of transcription factors" "ATM signaling pathway; ATM signaling in development and disease" "7" "0" "1.018" "1.395" "1.068" "1.029" "1.343" "0.989" "1.031" "1.406" "1.882" "689.8" "702.0" "962.2" "737.0" "710.1" "926.1" "682.2" "711.1" "970.2" "1298.4" "" "" "" "" "" "" "" "" "" "" "622.7" "541.5" "744.2" "496.3" "592.3" "790.4" "578.7" "514.6" "654.4" "1298.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949671281598126574" "False" "High" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "0.000" "False" "77.566" "15" "21" "23" "19" "1354" "158.1" "5.90" "70.00" "21" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; Apoptotic cleavage of cellular proteins; EPHB-mediated forward signaling; Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; RND3 GTPase cycle; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "35" "2" "0.910" "0.822" "0.969" "0.905" "0.818" "0.950" "0.926" "0.817" "1.622" "984.4" "896.0" "809.6" "954.2" "891.0" "804.9" "934.8" "911.4" "804.3" "1596.5" "" "" "" "" "" "" "" "" "" "" "888.6" "691.1" "626.2" "642.6" "743.2" "687.0" "793.0" "659.5" "542.5" "1596.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3676506683142235675" "False" "High" "IsMasterProtein" "Q9NZN3" "EH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=EHD3 PE=1 SV=2" "0.000" "False" "77.560" "24" "12" "32" "6" "535" "60.8" "6.57" "92.34" "12" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30845" "ENSG00000013016" "EHD3" "B4DFR5; D6W574; hsa:30845; Q8N514; Q9NZB3; Q9NZN3" "Factors involved in megakaryocyte development and platelet production" "Ciliary landscape" "2" "0" "1.090" "0.756" "1.105" "1.000" "0.874" "1.041" "1.058" "0.760" "0.866" "465.8" "507.8" "352.1" "514.7" "465.9" "406.9" "484.8" "492.8" "354.0" "403.5" "" "" "" "" "" "" "" "" "" "" "420.4" "391.7" "272.3" "346.6" "388.7" "347.3" "411.2" "356.6" "238.7" "403.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049594169438393906" "False" "High" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "0.000" "False" "77.489" "18" "6" "20" "6" "433" "45.5" "8.69" "74.42" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "tRNA processing in the nucleus" "" "1" "0" "0.987" "0.940" "0.955" "0.982" "0.973" "0.903" "0.951" "0.896" "1.007" "780.8" "770.4" "734.2" "745.3" "766.8" "759.6" "705.3" "742.6" "699.6" "786.1" "" "" "" "" "" "" "" "" "" "" "704.8" "594.2" "567.8" "501.9" "639.6" "648.3" "598.3" "537.4" "471.9" "786.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2651873567954206530" "False" "High" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "0.000" "False" "77.417" "13" "13" "18" "13" "1176" "134.4" "7.30" "57.88" "13" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "0.995" "0.848" "0.961" "1.053" "0.799" "1.060" "0.787" "0.843" "3.797" "703.0" "699.5" "596.3" "675.6" "740.0" "562.0" "745.1" "553.4" "592.8" "2669.6" "" "" "" "" "" "" "" "" "" "" "634.6" "539.6" "461.2" "454.9" "617.3" "479.7" "632.1" "400.5" "399.9" "2669.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084755087725056383" "False" "High" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "0.000" "False" "77.415" "17" "14" "19" "14" "1023" "112.8" "5.49" "66.35" "14" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "6" "0" "1.109" "1.067" "1.134" "1.047" "0.860" "1.098" "1.098" "0.985" "0.593" "765.6" "849.5" "816.8" "868.6" "801.9" "658.2" "840.4" "840.8" "754.3" "453.8" "" "" "" "" "" "" "" "" "" "" "691.1" "655.2" "631.7" "584.9" "668.9" "561.8" "712.9" "608.4" "508.8" "453.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141032543915842811" "False" "High" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "0.000" "False" "77.404" "23" "7" "32" "7" "328" "35.8" "8.00" "99.66" "7" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Mitochondrial protein degradation; Peroxisomal protein import" "Fatty acid biosynthesis; IL-18 signaling pathway" "4" "0" "1.007" "1.077" "1.027" "1.004" "1.084" "0.960" "0.954" "1.093" "0.638" "1853.9" "1866.7" "1997.4" "1904.7" "1861.3" "2008.9" "1779.9" "1768.6" "2026.4" "1182.2" "" "" "" "" "" "" "" "" "" "" "1673.5" "1439.9" "1544.8" "1282.6" "1552.6" "1714.6" "1509.9" "1279.9" "1366.8" "1182.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8320203953169685442" "False" "High" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "0.000" "False" "77.344" "39" "11" "26" "11" "334" "37.5" "7.36" "83.11" "11" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Ub-specific processing proteases; Methylation" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Spina bifida; Methylation pathways" "8" "0" "0.991" "0.974" "1.025" "0.985" "1.005" "0.967" "1.017" "1.025" "0.678" "1275.7" "1264.0" "1243.2" "1308.0" "1256.6" "1282.4" "1234.0" "1297.0" "1307.3" "864.6" "" "" "" "" "" "" "" "" "" "" "1151.6" "975.0" "961.5" "880.8" "1048.2" "1094.6" "1046.7" "938.6" "881.8" "864.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563058972091496350" "False" "High" "IsMasterProtein" "P80723" "Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2" "0.000" "False" "77.299" "37" "6" "17" "6" "227" "22.7" "4.63" "69.95" "6" "developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05466" "10409" "ENSG00000176788" "BASP1" "B4DJA8; D3DTD5; hsa:10409; O43596; P80723; Q5U0S0; Q9BWA5" "RHOF GTPase cycle" "" "1" "0" "1.075" "1.260" "1.013" "0.978" "1.230" "1.064" "1.189" "1.215" "0.725" "2063.4" "2218.7" "2600.3" "2089.9" "2017.7" "2537.1" "2195.8" "2454.2" "2508.0" "1496.5" "" "" "" "" "" "" "" "" "" "" "1862.6" "1711.4" "2011.2" "1407.3" "1683.1" "2165.5" "1862.6" "1776.1" "1691.6" "1496.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1088137077242897803" "False" "High" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "0.000" "False" "77.281" "18" "11" "15" "11" "736" "79.6" "8.84" "57.73" "11" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "10" "0" "1.008" "0.954" "0.976" "0.981" "0.982" "1.006" "0.989" "0.983" "0.633" "818.6" "825.3" "781.2" "799.1" "802.8" "803.8" "823.7" "809.5" "804.5" "518.3" "" "" "" "" "" "" "" "" "" "" "738.9" "636.6" "604.2" "538.1" "669.7" "686.1" "698.8" "585.8" "542.7" "518.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8372900262212064526" "False" "High" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "0.000" "False" "77.275" "32" "10" "44" "7" "372" "38.7" "9.13" "134.18" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "mRNA processing" "6" "1" "1.045" "1.138" "1.021" "1.134" "1.278" "1.092" "1.034" "1.290" "1.241" "1292.8" "1351.6" "1471.2" "1319.5" "1466.1" "1652.2" "1412.0" "1336.5" "1667.1" "1604.8" "" "" "" "" "" "" "" "" "" "" "1167.0" "1042.5" "1137.9" "888.6" "1223.0" "1410.1" "1197.8" "967.2" "1124.4" "1604.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6898362588139573585" "False" "High" "IsMasterProtein" "Q01105" "Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3" "0.000" "False" "76.870" "30" "8" "45" "8" "290" "33.5" "4.32" "163.21" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00956" "6418" "ENSG00000119335" "SET" "A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5" "HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes" "Histone modifications; VEGFA-VEGFR2 signaling" "4" "0" "1.067" "1.142" "1.002" "0.993" "1.190" "1.036" "1.107" "1.153" "0.859" "2035.2" "2171.0" "2323.2" "2038.3" "2019.9" "2421.5" "2108.3" "2252.8" "2346.5" "1748.7" "" "" "" "" "" "" "" "" "" "" "1837.1" "1674.6" "1796.9" "1372.6" "1684.9" "2066.7" "1788.4" "1630.3" "1582.7" "1748.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479686062085054609" "False" "High" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "0.000" "False" "76.802" "35" "10" "26" "5" "356" "37.5" "7.09" "82.07" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "Ferroptosis" "3" "6" "0.973" "0.926" "1.015" "0.994" "0.949" "0.943" "0.861" "0.914" "1.675" "1414.2" "1376.0" "1309.2" "1434.9" "1406.0" "1342.4" "1334.1" "1218.1" "1292.7" "2368.4" "" "" "" "" "" "" "" "" "" "" "1276.6" "1061.4" "1012.6" "966.3" "1172.8" "1145.7" "1131.7" "881.6" "871.9" "2368.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8484028389043526679" "False" "High" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "0.000" "False" "76.797" "16" "11" "19" "11" "732" "82.7" "5.81" "68.93" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network" "9" "0" "0.896" "3.589" "1.113" "0.953" "3.494" "0.929" "0.564" "3.608" "5.913" "719.2" "644.8" "2581.2" "800.8" "685.5" "2513.0" "668.4" "405.5" "2594.7" "4253.0" "" "" "" "" "" "" "" "" "" "" "649.2" "497.3" "1996.4" "539.2" "571.8" "2144.8" "567.0" "293.5" "1750.1" "4253.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2420827179212213562" "False" "High" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "0.000" "False" "76.796" "15" "21" "25" "18" "1438" "162.1" "5.36" "73.35" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation; PAFAH1B1 copy number variation" "9" "0" "1.067" "1.033" "1.003" "1.027" "1.116" "1.007" "0.979" "1.087" "0.886" "840.7" "897.0" "868.6" "843.6" "863.7" "938.3" "846.5" "823.4" "914.0" "745.1" "" "" "" "" "" "" "" "" "" "" "758.9" "691.9" "671.8" "568.1" "720.4" "800.9" "718.0" "595.9" "616.5" "745.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "52020500018808800" "False" "High" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "0.000" "False" "76.766" "61" "8" "29" "8" "170" "18.7" "5.03" "102.81" "8" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "0.990" "0.995" "1.070" "0.980" "1.003" "0.981" "1.086" "0.925" "0.751" "1148.3" "1136.5" "1142.0" "1228.5" "1124.9" "1151.7" "1126.5" "1246.8" "1061.9" "862.4" "" "" "" "" "" "" "" "" "" "" "1036.5" "876.7" "883.3" "827.3" "938.3" "983.0" "955.6" "902.3" "716.2" "862.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3304952133381549298" "False" "High" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "0.000" "False" "76.749" "35" "10" "22" "10" "292" "33.5" "4.84" "78.55" "10" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "0" "0.993" "0.921" "0.969" "1.017" "0.845" "0.939" "1.072" "0.860" "0.751" "1985.0" "1970.6" "1828.0" "1922.7" "2018.1" "1676.8" "1863.8" "2128.5" "1707.0" "1490.8" "" "" "" "" "" "" "" "" "" "" "1791.8" "1520.0" "1413.8" "1294.8" "1683.4" "1431.2" "1581.0" "1540.4" "1151.4" "1490.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-797188196996991140" "False" "High" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "0.000" "False" "76.623" "31" "13" "22" "7" "499" "55.7" "5.62" "69.42" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "4" "3" "1.019" "0.820" "1.079" "1.031" "0.816" "0.981" "0.957" "0.823" "0.661" "1156.7" "1178.4" "948.4" "1248.4" "1192.2" "943.5" "1134.4" "1107.4" "951.9" "764.1" "" "" "" "" "" "" "" "" "" "" "1044.1" "909.0" "733.5" "840.7" "994.5" "805.3" "962.3" "801.4" "642.0" "764.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6400995593712089390" "False" "High" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "0.000" "False" "76.489" "12" "18" "24" "18" "1555" "177.1" "5.63" "76.88" "18" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "ER Quality Control Compartment (ERQC)" "IL-18 signaling pathway" "2" "0" "1.017" "1.079" "0.996" "1.030" "1.093" "1.036" "1.014" "1.140" "0.826" "1253.4" "1274.6" "1352.7" "1249.0" "1291.0" "1370.1" "1298.2" "1270.7" "1429.3" "1035.3" "" "" "" "" "" "" "" "" "" "" "1131.4" "983.1" "1046.3" "841.0" "1076.9" "1169.4" "1101.2" "919.6" "964.0" "1035.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001709167677346758" "False" "High" "IsMasterProtein" "Q9Y305" "Acyl-coenzyme A thioesterase 9, mitochondrial OS=Homo sapiens OX=9606 GN=ACOT9 PE=1 SV=2" "0.000" "False" "76.481" "28" "11" "25" "11" "439" "49.9" "8.60" "82.46" "11" "other metabolic processes" "mitochondrion" "other molecular function" "" "23597" "ENSG00000123130" "ACOT9" "B3KNC9; B7ZM94; hsa:23597; Q9Y305" "Mitochondrial Fatty Acid Beta-Oxidation" "VEGFA-VEGFR2 signaling" "2" "0" "1.021" "0.759" "0.999" "0.979" "0.808" "1.011" "1.010" "0.772" "0.747" "1324.7" "1353.2" "1005.0" "1323.4" "1297.3" "1070.5" "1339.8" "1337.8" "1022.2" "990.0" "" "" "" "" "" "" "" "" "" "" "1195.8" "1043.7" "777.3" "891.2" "1082.1" "913.7" "1136.5" "968.2" "689.5" "990.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669243048092869257" "False" "High" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "0.000" "False" "76.468" "30" "13" "26" "13" "426" "48.6" "5.31" "101.72" "13" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "Protein hydroxylation" "VEGFA-VEGFR2 signaling" "2" "0" "1.036" "0.830" "1.021" "1.023" "0.820" "0.982" "1.009" "0.819" "0.711" "2180.8" "2259.3" "1810.2" "2227.0" "2231.2" "1789.3" "2142.5" "2200.9" "1786.1" "1550.8" "" "" "" "" "" "" "" "" "" "" "1968.5" "1742.7" "1400.1" "1499.7" "1861.2" "1527.2" "1817.4" "1592.8" "1204.7" "1550.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273803465605434037" "False" "High" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "0.000" "False" "76.439" "24" "10" "34" "10" "408" "46.8" "7.12" "93.73" "10" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "" "2" "0" "1.046" "0.800" "1.073" "1.050" "0.874" "1.060" "0.949" "0.892" "1.540" "2887.8" "3019.7" "2310.3" "3098.3" "3033.6" "2522.6" "3062.4" "2739.5" "2576.7" "4447.9" "" "" "" "" "" "" "" "" "" "" "2606.7" "2329.2" "1786.9" "2086.4" "2530.5" "2153.0" "2597.8" "1982.5" "1738.0" "4447.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2386724705728610253" "False" "High" "IsMasterProtein" "Q9UHB6" "LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1" "0.000" "False" "76.390" "20" "16" "28" "15" "759" "85.2" "6.84" "82.74" "16" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "51474" "ENSG00000050405" "LIMA1" "B2RB09; hsa:51474; Q2TAN7; Q59FE8; Q9BVF2; Q9H8J1; Q9HBN5; Q9NX96; Q9NXC3; Q9NXU6; Q9P0H8; Q9UHB5; Q9UHB6" "" "" "0" "1" "1.016" "1.150" "1.010" "1.003" "1.053" "1.000" "1.083" "1.129" "0.757" "1419.4" "1441.7" "1632.5" "1434.1" "1423.9" "1495.2" "1419.7" "1537.1" "1602.8" "1074.4" "" "" "" "" "" "" "" "" "" "" "1281.3" "1112.0" "1262.7" "965.7" "1187.7" "1276.2" "1204.3" "1112.4" "1081.1" "1074.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8623682461858759698" "False" "High" "IsMasterProtein" "P54578" "Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3" "0.000" "False" "76.375" "26" "13" "31" "13" "494" "56.0" "5.30" "99.09" "13" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00443" "9097" "ENSG00000101557" "USP14" "B7Z4N8; hsa:9097; J3QRZ5; P54578; Q53XY5" "Ub-specific processing proteases; Regulation of NF-kappa B signaling" "" "2" "0" "0.994" "0.869" "1.015" "0.985" "0.824" "1.013" "0.995" "0.849" "1.130" "1792.0" "1780.4" "1557.4" "1819.3" "1765.2" "1475.7" "1815.4" "1783.8" "1520.6" "2024.2" "" "" "" "" "" "" "" "" "" "" "1617.6" "1373.3" "1204.5" "1225.1" "1472.5" "1259.6" "1540.0" "1290.9" "1025.6" "2024.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4685450292699183556" "False" "High" "IsMasterProtein" "P43246" "DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1" "0.000" "False" "76.369" "17" "15" "19" "15" "934" "104.7" "5.77" "64.84" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" "4436" "ENSG00000095002" "MSH2" "B4E2Z2; hsa:4436; O75488; P43246" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "12" "0" "0.985" "0.729" "0.968" "1.048" "0.864" "0.950" "0.929" "0.805" "1.356" "1100.7" "1084.7" "802.5" "1065.7" "1154.0" "951.0" "1046.1" "1022.6" "885.9" "1493.0" "" "" "" "" "" "" "" "" "" "" "993.5" "836.6" "620.7" "717.6" "962.6" "811.7" "887.4" "740.0" "597.5" "1493.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868843744032576337" "False" "High" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "0.000" "False" "76.198" "31" "16" "28" "16" "511" "57.2" "6.21" "84.96" "16" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "miR-517 relationship with ARCN1 and USP1" "3" "0" "0.952" "0.962" "1.047" "1.002" "0.982" "0.958" "0.922" "0.959" "0.909" "1753.7" "1669.0" "1687.6" "1835.7" "1757.1" "1722.7" "1680.8" "1616.3" "1681.2" "1593.9" "" "" "" "" "" "" "" "" "" "" "1583.1" "1287.4" "1305.2" "1236.1" "1465.7" "1470.3" "1425.8" "1169.7" "1134.0" "1593.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6804108956499343623" "False" "High" "IsMasterProtein" "Q96G03" "Phosphopentomutase OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4" "0.000" "False" "76.149" "25" "16" "23" "15" "612" "68.2" "6.73" "75.12" "16" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "55276" "ENSG00000169299" "PGM2" "B4E0G8; hsa:55276; Q53FP5; Q5QTR0; Q96G03; Q9H0P9; Q9NV22" "Neutrophil degranulation; Pentose phosphate pathway" "Clear cell renal cell carcinoma pathways; Glucuronidation" "4" "0" "1.040" "1.077" "1.030" "1.061" "1.149" "0.987" "0.978" "1.129" "0.722" "1522.3" "1582.5" "1640.0" "1568.0" "1615.9" "1749.0" "1502.6" "1488.3" "1719.2" "1098.7" "" "" "" "" "" "" "" "" "" "" "1374.1" "1220.6" "1268.5" "1055.9" "1347.9" "1492.8" "1274.7" "1077.1" "1159.6" "1098.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074215629290594570" "False" "High" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "0.000" "False" "76.090" "45" "14" "41" "12" "353" "37.4" "8.95" "122.84" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "4" "2" "1.069" "1.267" "1.180" "1.109" "1.289" "1.109" "0.989" "1.447" "2.008" "1758.3" "1878.8" "2227.4" "2074.1" "1949.6" "2266.8" "1950.2" "1739.1" "2544.0" "3531.1" "" "" "" "" "" "" "" "" "" "" "1587.2" "1449.2" "1722.7" "1396.7" "1626.3" "1934.8" "1654.4" "1258.6" "1715.9" "3531.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215357132518723376" "False" "High" "IsMasterProtein" "P30040" "Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4" "0.000" "False" "75.971" "39" "8" "29" "8" "261" "29.0" "7.31" "84.08" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf07749, Pf07912" "10961" "ENSG00000089248" "ERP29" "C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4" "" "" "0" "0" "0.944" "0.951" "1.002" "0.978" "1.008" "0.958" "0.971" "0.986" "0.716" "1287.0" "1215.3" "1224.6" "1289.9" "1259.1" "1297.5" "1233.0" "1250.3" "1269.4" "921.7" "" "" "" "" "" "" "" "" "" "" "1161.8" "937.4" "947.1" "868.6" "1050.3" "1107.4" "1046.0" "904.8" "856.2" "921.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6837951581036984725" "False" "High" "IsMasterProtein" "P33241" "Lymphocyte-specific protein 1 OS=Homo sapiens OX=9606 GN=LSP1 PE=1 SV=1" "0.000" "False" "75.717" "46" "11" "22" "11" "339" "37.2" "4.74" "78.82" "11" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton" "cytoskeletal activity" "Pf02029" "4046" "ENSG00000130592; ENSG00000288199" "LSP1" "B3KPP1; B3KRR6; E9PBV6; E9PFP3; hsa:4046; P33241; Q16096; Q53H48; Q6FHM3; Q9BUY8" "" "" "0" "0" "1.024" "1.295" "1.073" "1.024" "1.221" "1.074" "1.112" "1.301" "0.756" "1346.5" "1379.0" "1743.7" "1444.6" "1378.3" "1644.0" "1445.6" "1497.7" "1752.1" "1018.0" "" "" "" "" "" "" "" "" "" "" "1215.4" "1063.7" "1348.7" "972.8" "1149.7" "1403.2" "1226.3" "1083.8" "1181.7" "1018.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-165801227635855458" "False" "High" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "0.000" "False" "75.667" "16" "12" "26" "12" "825" "90.5" "6.00" "89.70" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "4" "0" "1.035" "1.278" "0.894" "1.275" "1.404" "1.120" "0.876" "1.292" "4.777" "1104.3" "1142.5" "1411.6" "987.1" "1408.5" "1550.5" "1236.5" "967.3" "1426.6" "5275.5" "" "" "" "" "" "" "" "" "" "" "996.8" "881.3" "1091.8" "664.7" "1174.9" "1323.3" "1048.9" "700.0" "962.2" "5275.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037912225033679960" "False" "High" "IsMasterProtein" "P47756" "F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5" "0.000" "False" "75.663" "42" "10" "26" "10" "272" "30.6" "6.00" "85.19" "10" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01115" "832" "ENSG00000077549" "CAPZB" "hsa:832; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4" "MHC class II antigen presentation; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; RHOD GTPase cycle; RHOF GTPase cycle; Factors involved in megakaryocyte development and platelet production" "VEGFA-VEGFR2 signaling" "9" "0" "0.992" "1.213" "0.945" "0.993" "1.179" "0.949" "0.955" "1.240" "0.940" "1865.8" "1850.0" "2262.3" "1763.6" "1853.3" "2200.1" "1771.3" "1781.1" "2313.4" "1753.6" "" "" "" "" "" "" "" "" "" "" "1684.2" "1427.0" "1749.8" "1187.6" "1546.0" "1877.8" "1502.6" "1289.0" "1560.4" "1753.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729262198654758902" "False" "High" "IsMasterProtein" "O43396" "Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3" "0.000" "False" "75.583" "41" "9" "30" "9" "289" "32.2" "4.96" "90.24" "9" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00085, Pf06201" "9352" "ENSG00000091164" "TXNL1" "hsa:9352; O43396" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "" "7" "0" "0.936" "0.793" "1.095" "0.894" "0.798" "0.975" "0.873" "0.718" "1.396" "1256.5" "1176.1" "996.1" "1376.1" "1123.7" "1002.3" "1225.0" "1097.1" "901.8" "1754.0" "" "" "" "" "" "" "" "" "" "" "1134.2" "907.2" "770.4" "926.7" "937.4" "855.5" "1039.1" "793.9" "608.2" "1754.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011976368699827672" "False" "High" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "0.000" "False" "75.461" "31" "13" "26" "13" "472" "51.1" "8.40" "80.19" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "14" "0" "1.035" "0.945" "1.007" "1.013" "0.962" "0.988" "0.958" "0.961" "0.819" "1718.9" "1778.4" "1624.7" "1730.9" "1742.1" "1654.3" "1698.3" "1647.4" "1651.6" "1408.2" "" "" "" "" "" "" "" "" "" "" "1551.6" "1371.8" "1256.6" "1165.6" "1453.2" "1412.0" "1440.6" "1192.2" "1114.0" "1408.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538896593466497334" "False" "High" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "0.000" "False" "74.970" "48" "9" "51" "8" "166" "18.5" "8.09" "156.40" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Platelet degranulation ; Regulation of actin dynamics for phagocytic cup formation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "15" "0" "1.004" "1.208" "1.010" "1.095" "1.335" "1.116" "1.138" "1.190" "0.873" "2681.6" "2691.6" "3239.5" "2708.6" "2936.0" "3579.2" "2991.5" "3050.9" "3191.9" "2340.1" "" "" "" "" "" "" "" "" "" "" "2420.6" "2076.1" "2505.5" "1824.0" "2449.1" "3054.9" "2537.7" "2207.9" "2152.9" "2340.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7233412111740596343" "False" "High" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "0.000" "False" "74.922" "18" "15" "19" "14" "917" "102.4" "6.80" "58.25" "15" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "12" "1" "1.071" "1.060" "1.003" "1.065" "1.055" "1.039" "1.047" "1.062" "0.767" "1169.9" "1252.8" "1240.6" "1173.9" "1245.5" "1233.8" "1216.1" "1225.5" "1242.4" "897.5" "" "" "" "" "" "" "" "" "" "" "1056.1" "966.4" "959.5" "790.5" "1038.9" "1053.1" "1031.6" "886.9" "838.0" "897.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479793662138796228" "False" "High" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "0.000" "False" "74.794" "23" "14" "29" "14" "599" "67.3" "8.34" "91.00" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "OAS antiviral response; Interferon alpha/beta signaling" "" "2" "0" "1.027" "1.030" "1.081" "1.032" "1.062" "1.027" "1.017" "1.108" "0.860" "1649.4" "1693.1" "1699.4" "1782.5" "1702.9" "1750.9" "1693.6" "1678.0" "1827.1" "1418.0" "" "" "" "" "" "" "" "" "" "" "1488.9" "1306.0" "1314.4" "1200.3" "1420.5" "1494.4" "1436.7" "1214.3" "1232.3" "1418.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064458318068970757" "False" "High" "IsMasterProtein" "Q96QK1" "Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2" "0.000" "False" "74.715" "18" "13" "19" "13" "796" "91.6" "5.49" "67.39" "13" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf03635" "55737" "ENSG00000069329" "VPS35" "hsa:55737; Q561W2; Q96QK1; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2" "WNT ligand biogenesis and trafficking" "" "1" "0" "1.106" "0.967" "1.096" "1.027" "1.032" "1.031" "0.971" "0.976" "0.893" "539.2" "596.2" "521.7" "590.8" "553.6" "556.5" "555.8" "523.8" "526.5" "481.3" "" "" "" "" "" "" "" "" "" "" "486.7" "459.9" "403.5" "397.9" "461.8" "475.0" "471.4" "379.0" "355.1" "481.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431694603937659134" "False" "High" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "0.000" "False" "74.602" "47" "8" "48" "4" "152" "17.1" "6.19" "141.62" "8" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "Pyrimidine metabolism" "4" "0" "0.990" "1.106" "0.978" "1.046" "1.082" "1.017" "0.941" "1.073" "0.657" "1386.0" "1372.1" "1532.6" "1355.4" "1449.7" "1500.1" "1408.9" "1303.8" "1487.1" "910.8" "" "" "" "" "" "" "" "" "" "" "1251.1" "1058.4" "1185.4" "912.7" "1209.3" "1280.4" "1195.1" "943.6" "1003.0" "910.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6088825967158896660" "False" "High" "IsMasterProtein" "O43290" "U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1" "0.000" "False" "74.574" "21" "13" "18" "13" "800" "90.2" "6.13" "61.73" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03343, Pf19252" "9092" "ENSG00000175467" "SART1" "A6NDN1; hsa:9092; O43290; Q53GB5" "mRNA Splicing - Major Pathway" "" "1" "0" "1.052" "1.057" "1.148" "1.096" "1.144" "1.076" "1.074" "1.133" "0.776" "686.8" "722.4" "726.1" "788.4" "752.4" "785.9" "739.0" "737.3" "778.1" "532.8" "" "" "" "" "" "" "" "" "" "" "619.9" "557.2" "561.6" "530.9" "627.6" "670.8" "626.9" "533.6" "524.8" "532.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1130211750852848646" "False" "High" "IsMasterProtein" "Q13404" "Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2" "0.000" "False" "74.203" "52" "7" "35" "3" "147" "16.5" "7.93" "99.29" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00179" "387522; 7335" "ENSG00000244687" "UBE2V1" "E1P629; hsa:387522; hsa:7335; Q13403; Q13404; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aggrephagy; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "19" "4" "0.979" "0.978" "1.011" "0.984" "1.026" "0.989" "1.010" "1.061" "0.676" "1039.4" "1017.6" "1016.7" "1050.5" "1022.8" "1066.7" "1027.5" "1049.9" "1102.6" "702.4" "" "" "" "" "" "" "" "" "" "" "938.2" "784.9" "786.4" "707.4" "853.2" "910.4" "871.6" "759.8" "743.7" "702.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45443448741042807" "False" "High" "IsMasterProtein" "P24928" "DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2" "0.000" "False" "74.191" "11" "21" "27" "21" "1970" "217.0" "7.37" "83.66" "21" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001" "5430" "" "POLR2A" "A6NN93; B9EH88; hsa:5430; P24928; Q6NX41" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing" "44" "0" "0.969" "0.926" "0.960" "1.022" "0.928" "1.003" "0.999" "0.956" "1.085" "981.5" "951.2" "908.6" "942.0" "1003.5" "911.3" "984.7" "980.5" "938.5" "1064.7" "" "" "" "" "" "" "" "" "" "" "886.0" "733.7" "702.7" "634.3" "837.1" "777.8" "835.3" "709.6" "633.0" "1064.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1734790582977372175" "False" "High" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "0.000" "False" "74.073" "25" "16" "24" "16" "660" "75.3" "6.68" "73.32" "16" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Amino acid metabolism" "3" "0" "0.982" "0.843" "0.995" "0.979" "0.806" "0.907" "0.777" "0.860" "2.964" "858.6" "843.3" "724.1" "854.1" "840.8" "692.3" "779.1" "667.1" "738.7" "2544.7" "" "" "" "" "" "" "" "" "" "" "775.1" "650.5" "560.1" "575.2" "701.4" "590.9" "660.9" "482.8" "498.3" "2544.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4886602285452216196" "False" "High" "IsMasterProtein" "Q92696" "Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2" "0.000" "False" "73.984" "28" "15" "25" "15" "567" "65.0" "5.67" "76.75" "15" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00560, Pf01239, Pf07711" "5875" "ENSG00000100949; ENSG00000285193" "RABGGTA" "A8K5N2; D3DS69; hsa:5875; Q92696" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "" "2" "0" "1.027" "0.999" "0.949" "0.963" "1.054" "0.958" "0.956" "1.010" "0.780" "674.1" "692.1" "673.2" "639.7" "648.9" "710.2" "645.5" "644.6" "681.0" "525.7" "" "" "" "" "" "" "" "" "" "" "608.5" "533.9" "520.7" "430.8" "541.3" "606.1" "547.6" "466.5" "459.3" "525.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256235105362563928" "False" "High" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "0.000" "False" "73.871" "45" "9" "122" "8" "165" "18.0" "7.81" "308.95" "9" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "Prolactin signaling pathway" "16" "0" "1.018" "1.022" "1.045" "0.998" "1.057" "1.052" "1.001" "1.030" "0.946" "6230.2" "6344.5" "6365.1" "6512.8" "6220.6" "6588.2" "6555.1" "6238.3" "6415.5" "5891.6" "" "" "" "" "" "" "" "" "" "" "5623.8" "4893.8" "4923.0" "4385.7" "5189.0" "5623.1" "5560.5" "4514.6" "4327.2" "5891.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3259999118554299265" "False" "High" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "0.000" "False" "73.863" "29" "12" "32" "11" "437" "50.6" "8.63" "90.94" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "MAPK6/MAPK4 signaling" "" "1" "1" "0.992" "1.064" "0.963" "1.003" "1.041" "1.065" "1.016" "1.066" "0.788" "1790.2" "1775.2" "1904.2" "1723.8" "1796.4" "1863.3" "1907.2" "1818.3" "1909.3" "1410.1" "" "" "" "" "" "" "" "" "" "" "1616.0" "1369.3" "1472.8" "1160.8" "1498.5" "1590.4" "1617.8" "1315.9" "1287.8" "1410.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815145421053809259" "False" "High" "IsMasterProtein" "Q16543" "Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1" "0.000" "False" "73.815" "31" "11" "33" "11" "378" "44.4" "5.25" "111.73" "11" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf03234, Pf08564, Pf08565" "11140" "ENSG00000105401" "CDC37" "hsa:11140; Q16543; Q53YA2" "Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RHOBTB2 GTPase cycle; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "27" "0" "1.014" "0.923" "1.195" "1.031" "0.943" "1.051" "1.058" "0.994" "0.749" "2518.4" "2552.7" "2323.5" "3008.7" "2596.8" "2375.8" "2646.1" "2665.5" "2504.1" "1887.4" "" "" "" "" "" "" "" "" "" "" "2273.3" "1969.0" "1797.1" "2026.1" "2166.1" "2027.8" "2244.7" "1929.0" "1689.0" "1887.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629883586476679929" "False" "High" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "0.000" "False" "73.545" "31" "11" "22" "11" "406" "46.2" "5.83" "80.20" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle" "Ciliary landscape" "6" "0" "0.987" "0.939" "0.960" "0.990" "1.021" "1.007" "1.018" "1.018" "0.728" "1087.9" "1074.2" "1021.5" "1044.8" "1077.1" "1111.1" "1095.2" "1107.7" "1107.8" "792.4" "" "" "" "" "" "" "" "" "" "" "982.0" "828.6" "790.0" "703.6" "898.5" "948.3" "929.1" "801.6" "747.2" "792.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8545908257350266971" "False" "High" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "0.000" "False" "73.501" "37" "12" "46" "12" "300" "34.3" "7.36" "131.36" "12" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "0.970" "1.066" "0.932" "0.986" "1.087" "0.954" "1.004" "1.070" "0.710" "3367.0" "3265.8" "3588.9" "3136.9" "3320.4" "3659.6" "3211.1" "3379.6" "3603.8" "2392.0" "" "" "" "" "" "" "" "" "" "" "3039.3" "2519.1" "2775.8" "2112.4" "2769.7" "3123.6" "2724.0" "2445.8" "2430.7" "2392.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5275540959932174837" "False" "High" "IsMasterProtein" "Q14847" "LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2" "0.000" "False" "73.438" "45" "12" "27" "12" "261" "29.7" "7.05" "91.50" "12" "transport" "cytoskeleton;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00412, Pf00880, Pf14604" "3927" "ENSG00000002834" "LASP1" "B4DGQ0; hsa:3927; Q14847; Q96ED2; Q96IG0" "" "17q12 copy number variation syndrome" "1" "0" "0.989" "1.070" "0.984" "0.965" "1.009" "1.031" "1.138" "0.957" "0.675" "1332.7" "1318.2" "1425.7" "1311.4" "1286.3" "1345.4" "1373.8" "1516.3" "1276.0" "899.9" "" "" "" "" "" "" "" "" "" "" "1203.0" "1016.8" "1102.7" "883.1" "1073.0" "1148.3" "1165.4" "1097.3" "860.7" "899.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469246297971201094" "False" "High" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "0.000" "False" "73.203" "19" "10" "15" "10" "594" "67.2" "5.96" "59.16" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "0.974" "0.759" "0.884" "0.976" "0.765" "0.970" "0.976" "0.777" "0.727" "1226.4" "1194.2" "930.7" "1084.7" "1196.8" "938.1" "1189.3" "1197.4" "952.4" "891.3" "" "" "" "" "" "" "" "" "" "" "1107.0" "921.2" "719.8" "730.4" "998.3" "800.7" "1008.9" "866.5" "642.4" "891.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9009655612245832545" "False" "High" "IsMasterProtein" "Q9Y4G6" "Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4" "0.000" "False" "73.054" "5" "13" "20" "5" "2542" "271.4" "5.57" "64.50" "13" "cell adhesion;cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf09379, Pf16511, Pf21692" "83660" "ENSG00000171914" "TLN2" "A6NLB8; hsa:83660; Q9Y4G6" "" "Focal adhesion" "1" "1" "0.983" "1.274" "0.936" "0.971" "1.059" "1.171" "1.058" "1.155" "0.564" "493.0" "484.7" "627.9" "461.5" "478.7" "522.2" "577.4" "521.6" "569.2" "278.1" "" "" "" "" "" "" "" "" "" "" "445.0" "373.8" "485.6" "310.8" "399.3" "445.7" "489.8" "377.4" "383.9" "278.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8428260618384848940" "False" "High" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "0.000" "False" "73.024" "17" "15" "23" "14" "972" "109.4" "5.00" "68.74" "15" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; Ciliary landscape" "4" "0" "1.041" "0.999" "0.922" "0.989" "1.002" "0.992" "0.971" "0.894" "0.603" "902.7" "940.1" "902.2" "832.3" "892.6" "905.0" "895.9" "876.8" "806.8" "544.1" "" "" "" "" "" "" "" "" "" "" "814.9" "725.1" "697.8" "560.4" "744.6" "772.4" "760.0" "634.5" "544.2" "544.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6826541305752528518" "False" "High" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "0.000" "False" "73.009" "22" "9" "27" "9" "471" "53.1" "6.23" "87.06" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Cytosolic tRNA aminoacylation" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "3" "0" "1.015" "0.910" "0.992" "1.050" "0.923" "1.016" "1.020" "0.925" "0.751" "1962.6" "1991.4" "1785.7" "1947.4" "2060.8" "1811.9" "1994.9" "2002.3" "1815.8" "1474.3" "" "" "" "" "" "" "" "" "" "" "1771.6" "1536.0" "1381.1" "1311.4" "1719.1" "1546.5" "1692.3" "1449.0" "1224.7" "1474.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815926444524445653" "False" "High" "IsMasterProtein" "Q7Z406" "Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2" "0.000" "False" "72.845" "4" "9" "25" "1" "1995" "227.7" "5.60" "89.48" "9" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "79784" "ENSG00000105357" "MYH14" "B0I1S2; C3TTN4; hsa:79784; Q5CZ75; Q6XYE4; Q76B62; Q7Z406; Q8WV23; Q96I22; Q9BT27; Q9BW35; Q9H882" "EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases activate PAKs" "" "6" "0" "1.011" "0.878" "0.846" "0.869" "0.654" "0.808" "0.916" "0.990" "0.932" "78.9" "79.7" "69.3" "66.7" "68.6" "51.6" "63.8" "72.2" "78.1" "73.5" "" "" "" "" "" "" "" "" "" "" "71.2" "61.5" "53.6" "44.9" "57.2" "44.1" "54.1" "52.3" "52.6" "73.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4969785199518402327" "False" "High" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "0.000" "False" "72.827" "26" "11" "22" "11" "491" "55.5" "6.74" "84.20" "11" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602, Pf21151" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "" "5" "0" "0.988" "1.033" "0.933" "1.068" "0.984" "1.017" "1.052" "0.971" "0.752" "1915.1" "1891.3" "1977.4" "1786.8" "2044.4" "1885.4" "1947.3" "2014.2" "1860.0" "1440.6" "" "" "" "" "" "" "" "" "" "" "1728.7" "1458.8" "1529.4" "1203.2" "1705.3" "1609.2" "1651.9" "1457.7" "1254.6" "1440.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7512060777885112035" "False" "High" "IsMasterProtein" "P63244" "Small ribosomal subunit protein RACK1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "0.000" "False" "72.440" "40" "12" "28" "12" "317" "35.1" "7.69" "92.24" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "10" "0" "0.955" "1.090" "1.104" "1.073" "1.079" "1.060" "1.044" "1.085" "0.699" "1184.0" "1130.3" "1290.2" "1306.8" "1270.4" "1278.0" "1255.1" "1236.1" "1285.0" "827.8" "" "" "" "" "" "" "" "" "" "" "1068.8" "871.8" "997.9" "880.0" "1059.8" "1090.8" "1064.7" "894.6" "866.7" "827.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8881976693439910842" "False" "High" "IsMasterProtein" "P40306" "Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1" "0.000" "False" "72.101" "28" "6" "15" "6" "273" "28.9" "7.81" "65.60" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5699" "ENSG00000205220" "PSMB10" "B2R5J4; hsa:5699; P40306; Q5U098" "FCERI mediated NF-kB activation; Downstream TCR signaling; Degradation of beta-catenin by the destruction complex; Separation of Sister Chromatids; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation" "60" "0" "0.948" "1.006" "1.034" "0.976" "1.048" "0.968" "0.981" "1.047" "0.695" "1044.8" "990.5" "1050.6" "1080.1" "1019.9" "1094.7" "1011.8" "1024.8" "1094.3" "726.6" "" "" "" "" "" "" "" "" "" "" "943.1" "764.0" "812.6" "727.3" "850.8" "934.4" "858.3" "741.6" "738.1" "726.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1304014562382960910" "False" "High" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "0.000" "False" "71.885" "23" "12" "18" "12" "631" "71.6" "4.65" "55.20" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "13" "0" "1.013" "0.858" "1.023" "1.064" "0.824" "1.033" "0.961" "0.929" "0.665" "435.5" "441.1" "373.5" "445.3" "463.3" "358.7" "450.0" "418.7" "404.5" "289.6" "" "" "" "" "" "" "" "" "" "" "393.1" "340.2" "288.9" "299.9" "386.4" "306.1" "381.8" "303.0" "272.8" "289.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3249613255715037073" "False" "High" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "0.000" "False" "71.736" "41" "9" "42" "9" "224" "25.0" "6.38" "124.92" "9" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "5" "0" "1.000" "0.873" "0.967" "0.870" "0.938" "0.922" "0.996" "0.852" "0.662" "1547.0" "1546.5" "1351.1" "1495.8" "1346.0" "1451.6" "1425.8" "1541.3" "1317.3" "1023.6" "" "" "" "" "" "" "" "" "" "" "1396.4" "1192.9" "1045.0" "1007.3" "1122.8" "1238.9" "1209.5" "1115.5" "888.5" "1023.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5156803787758571728" "False" "High" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "0.000" "False" "71.720" "13" "10" "24" "10" "709" "78.3" "5.25" "77.45" "10" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "0.975" "1.173" "0.981" "1.045" "1.336" "0.918" "0.995" "1.198" "0.729" "1596.3" "1556.0" "1872.5" "1566.4" "1667.6" "2132.2" "1465.7" "1589.1" "1912.3" "1163.4" "" "" "" "" "" "" "" "" "" "" "1441.0" "1200.2" "1448.2" "1054.8" "1391.1" "1819.8" "1243.3" "1150.0" "1289.9" "1163.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5122002380756434681" "False" "High" "IsMasterProtein" "Q9Y6E2" "eIF5-mimic protein 1 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1" "0.000" "False" "71.644" "33" "15" "30" "14" "419" "48.1" "6.68" "91.90" "15" "other biological processes" "other cell component" "" "Pf02020" "28969" "ENSG00000136261" "BZW2" "A4D123; hsa:28969; Q3B779; Q96JW5; Q9H3F7; Q9Y6E2" "" "" "0" "0" "0.993" "0.933" "0.962" "0.937" "0.893" "0.953" "0.989" "0.916" "0.924" "2155.1" "2141.1" "2011.5" "2072.2" "2019.4" "1923.5" "2053.0" "2132.3" "1974.6" "1991.7" "" "" "" "" "" "" "" "" "" "" "1945.3" "1651.5" "1555.7" "1395.4" "1684.5" "1641.7" "1741.5" "1543.1" "1331.8" "1991.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "523405854747225660" "False" "High" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "0.000" "False" "71.627" "25" "12" "20" "10" "522" "58.7" "6.33" "64.37" "12" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "1" "1.033" "0.970" "1.097" "1.101" "1.012" "1.097" "1.035" "1.022" "0.743" "479.3" "495.3" "464.9" "525.9" "527.7" "485.1" "525.7" "495.9" "490.0" "356.2" "" "" "" "" "" "" "" "" "" "" "432.6" "382.0" "359.6" "354.2" "440.2" "414.0" "446.0" "358.9" "330.5" "356.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101448346661809879" "False" "High" "IsMasterProtein" "Q15819" "Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4" "0.000" "False" "71.617" "52" "7" "30" "3" "145" "16.4" "8.09" "89.15" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00179" "7336" "ENSG00000169139" "UBE2V2" "hsa:7336; Q15819" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER" "" "7" "0" "0.911" "1.010" "0.989" "0.913" "1.072" "0.995" "0.982" "1.034" "0.790" "151.7" "138.1" "153.2" "150.0" "138.5" "162.5" "150.9" "149.0" "156.7" "119.8" "" "" "" "" "" "" "" "" "" "" "136.9" "106.5" "118.5" "101.0" "115.5" "138.7" "128.0" "107.8" "105.7" "119.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1764632123327779223" "False" "High" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "0.000" "False" "71.375" "19" "9" "16" "9" "587" "63.5" "4.68" "51.60" "9" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "12" "0" "0.974" "0.982" "0.967" "0.978" "1.090" "0.991" "0.829" "1.082" "2.288" "533.4" "519.7" "524.0" "515.7" "521.8" "581.6" "528.4" "442.4" "577.2" "1220.4" "" "" "" "" "" "" "" "" "" "" "481.5" "400.8" "405.3" "347.3" "435.3" "496.4" "448.2" "320.1" "389.3" "1220.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-933507358187812304" "False" "High" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "0.000" "False" "71.366" "8" "13" "13" "12" "2157" "228.7" "9.45" "47.25" "13" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "1.044" "0.906" "0.942" "1.103" "0.955" "0.991" "1.021" "0.881" "0.776" "469.2" "489.7" "425.2" "442.0" "517.7" "448.0" "465.0" "479.2" "413.2" "364.3" "" "" "" "" "" "" "" "" "" "" "423.5" "377.7" "328.9" "297.7" "431.8" "382.4" "394.4" "346.8" "278.7" "364.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4060364465058462245" "False" "High" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "0.000" "False" "71.310" "40" "14" "26" "14" "360" "41.5" "4.91" "64.18" "14" "other biological processes" "other cell component" "enzyme regulator activity" "Pf12799, Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "" "2q37 copy number variation syndrome" "1" "0" "1.002" "1.022" "0.921" "0.998" "1.067" "0.976" "0.985" "1.046" "0.877" "676.6" "678.2" "691.3" "623.2" "675.0" "722.2" "660.4" "666.1" "707.6" "593.6" "" "" "" "" "" "" "" "" "" "" "610.8" "523.1" "534.7" "419.6" "563.0" "616.4" "560.2" "482.1" "477.2" "593.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5999519850232784779" "False" "High" "IsMasterProtein" "Q9Y3L3" "SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3" "0.000" "False" "71.267" "21" "13" "23" "13" "701" "75.7" "6.77" "79.89" "13" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "23616" "ENSG00000100092" "SH3BP1" "hsa:23616; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9; Q9Y3L3" "RAC1 GTPase cycle" "" "1" "0" "0.981" "0.792" "0.962" "0.970" "0.774" "1.001" "0.944" "0.811" "0.916" "1281.3" "1256.6" "1014.8" "1232.8" "1243.1" "992.1" "1283.1" "1209.2" "1039.5" "1174.1" "" "" "" "" "" "" "" "" "" "" "1156.6" "969.3" "784.9" "830.2" "1036.9" "846.8" "1088.4" "875.1" "701.1" "1174.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7978508680545557598" "False" "High" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "0.000" "False" "71.123" "22" "14" "18" "14" "747" "85.1" "4.91" "56.89" "14" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "1.059" "1.039" "1.001" "1.207" "1.123" "1.073" "1.036" "1.026" "1.565" "754.2" "798.5" "783.5" "755.0" "909.9" "846.9" "809.0" "781.5" "773.8" "1180.0" "" "" "" "" "" "" "" "" "" "" "680.8" "615.9" "606.0" "508.4" "759.0" "722.8" "686.3" "565.6" "521.9" "1180.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6077570543552496726" "False" "High" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "0.000" "False" "70.957" "22" "12" "17" "12" "583" "63.4" "8.28" "62.56" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf13855" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "0.980" "0.931" "0.974" "0.979" "0.889" "0.988" "0.995" "0.914" "0.718" "1083.2" "1061.3" "1008.8" "1055.3" "1060.6" "963.4" "1070.7" "1077.8" "990.5" "778.0" "" "" "" "" "" "" "" "" "" "" "977.8" "818.6" "780.2" "710.6" "884.7" "822.3" "908.3" "780.0" "668.1" "778.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-15854148761745197" "False" "High" "IsMasterProtein" "Q6IN85" "Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1" "0.000" "False" "70.873" "19" "13" "21" "9" "833" "95.3" "4.94" "64.07" "13" "stress response" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "55671" "ENSG00000100796" "PPP4R3A" "hsa:55671; Q69YK6; Q6IN85; Q86U23; Q86YI7; Q8IVG1; Q9H3F1; Q9H7U8; Q9NV01; Q9NWP1" "" "16p11.2 proximal deletion syndrome" "1" "2" "1.022" "0.978" "0.971" "1.016" "0.959" "1.036" "1.013" "0.939" "1.056" "624.0" "637.7" "610.4" "606.1" "634.3" "598.5" "646.5" "632.2" "585.9" "659.2" "" "" "" "" "" "" "" "" "" "" "563.3" "491.9" "472.1" "408.2" "529.1" "510.9" "548.4" "457.5" "395.2" "659.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1393255483118757770" "False" "High" "IsMasterProtein" "Q9H2U2" "Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2" "0.000" "False" "70.831" "36" "10" "22" "9" "334" "37.9" "7.39" "66.77" "10" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00719" "27068" "ENSG00000138777" "PPA2" "B4DLP7; F8WDN9; hsa:27068; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9H2U2; Q9NX37; Q9P033; Q9ULX0" "Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis" "" "2" "0" "0.982" "0.973" "0.991" "0.985" "1.069" "0.949" "0.985" "1.021" "0.697" "585.0" "574.4" "569.1" "580.0" "576.1" "625.2" "554.9" "576.2" "597.3" "407.9" "" "" "" "" "" "" "" "" "" "" "528.1" "443.1" "440.1" "390.6" "480.6" "533.6" "470.7" "417.0" "402.9" "407.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4797790429512717329" "False" "High" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "0.000" "False" "70.556" "29" "12" "29" "11" "414" "46.6" "7.01" "75.10" "12" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "8" "0" "1.069" "1.186" "0.982" "1.116" "1.058" "1.138" "1.184" "1.066" "0.828" "1044.7" "1116.6" "1238.8" "1026.2" "1166.1" "1105.1" "1188.7" "1236.4" "1113.6" "864.6" "" "" "" "" "" "" "" "" "" "" "943.0" "861.3" "958.1" "691.0" "972.7" "943.2" "1008.3" "894.8" "751.1" "864.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154520297388586765" "False" "High" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "0.000" "False" "70.469" "20" "11" "23" "11" "563" "61.3" "7.68" "73.10" "11" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Branched-chain amino acid catabolism" "" "3" "0" "0.981" "1.098" "0.995" "1.059" "1.214" "0.994" "1.004" "1.149" "0.778" "1142.1" "1120.4" "1254.5" "1136.6" "1209.3" "1386.8" "1135.2" "1146.8" "1312.0" "888.7" "" "" "" "" "" "" "" "" "" "" "1031.0" "864.2" "970.2" "765.4" "1008.7" "1183.7" "963.0" "829.9" "885.0" "888.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2706346813500612186" "False" "High" "IsMasterProtein" "Q9C0C9" "(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3" "0.000" "False" "70.403" "13" "15" "23" "15" "1292" "141.2" "5.12" "67.76" "15" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "63893" "ENSG00000175931" "UBE2O" "A6NDU5; hsa:63893; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9C0C9; Q9H6E6; Q9H7E4; Q9H9B2" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.977" "0.958" "1.028" "1.001" "0.934" "1.000" "0.982" "0.978" "1.145" "977.1" "954.8" "936.1" "1004.9" "978.3" "913.0" "976.6" "959.3" "955.8" "1118.9" "" "" "" "" "" "" "" "" "" "" "882.0" "736.5" "724.0" "676.7" "816.1" "779.2" "828.5" "694.2" "644.7" "1118.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3348063048302493190" "False" "High" "IsMasterProtein" "P50851" "Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4" "0.000" "False" "70.242" "7" "18" "23" "18" "2863" "318.9" "5.60" "66.19" "18" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "987" "ENSG00000198589" "LRBA" "hsa:987; P50851; Q4W5J4; Q4W5L6; Q8NFQ0; Q9H2U3; Q9H2U4" "" "" "0" "0" "0.985" "0.807" "0.994" "0.919" "0.810" "0.938" "0.979" "0.840" "1.088" "1075.9" "1059.6" "868.4" "1068.9" "989.1" "871.2" "1009.4" "1053.1" "903.3" "1170.3" "" "" "" "" "" "" "" "" "" "" "971.2" "817.3" "671.7" "719.8" "825.1" "743.5" "856.3" "762.1" "609.3" "1170.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5793722554403523201" "False" "High" "IsMasterProtein" "Q14764" "Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4" "0.000" "False" "70.068" "18" "14" "17" "14" "893" "99.3" "5.48" "61.81" "14" "transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01505, Pf11978, Pf17794, Pf17795, Pf17796" "9961" "ENSG00000013364" "MVP" "hsa:9961; Q14764; Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1" "Neutrophil degranulation" "16p11.2 proximal deletion syndrome" "2" "0" "1.078" "1.259" "1.150" "1.111" "1.210" "1.110" "1.095" "1.257" "0.840" "888.2" "957.9" "1118.0" "1021.2" "986.5" "1074.9" "985.8" "972.5" "1116.5" "745.9" "" "" "" "" "" "" "" "" "" "" "801.8" "738.9" "864.7" "687.7" "822.9" "917.4" "836.2" "703.8" "753.0" "745.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5384337703464320291" "False" "High" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "0.000" "False" "69.926" "19" "13" "24" "13" "640" "70.7" "7.62" "74.45" "13" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Gluconeogenesis" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "7" "0" "1.098" "1.022" "1.098" "1.156" "1.092" "1.113" "1.107" "1.096" "0.887" "864.3" "948.9" "883.0" "949.2" "998.7" "943.8" "962.4" "956.5" "946.9" "767.0" "" "" "" "" "" "" "" "" "" "" "780.2" "731.9" "683.0" "639.2" "833.1" "805.5" "816.4" "692.2" "638.7" "767.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813014236257881133" "False" "High" "IsMasterProtein" "P21291" "Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3" "0.000" "False" "69.877" "51" "8" "19" "8" "193" "20.6" "8.57" "69.31" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1465" "ENSG00000159176" "CSRP1" "A8K268; hsa:1465; P21291; Q5U0J2" "MTF1 activates gene expression" "MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling" "3" "0" "1.007" "1.072" "0.887" "1.008" "1.135" "0.985" "1.088" "1.135" "0.708" "1499.0" "1508.9" "1606.8" "1330.2" "1511.6" "1700.8" "1475.8" "1631.2" "1702.0" "1062.0" "" "" "" "" "" "" "" "" "" "" "1353.1" "1163.9" "1242.8" "895.8" "1260.9" "1451.7" "1251.9" "1180.5" "1148.0" "1062.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "217416082876923675" "False" "High" "IsMasterProtein" "O75410" "Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2" "0.000" "False" "69.770" "21" "13" "15" "13" "805" "87.7" "4.88" "49.87" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05010" "6867" "ENSG00000147526" "TACC1" "B2RBD9; B4E302; D3DSX6; hsa:6867; O75410; Q6Y687; Q86YG7; Q8IUJ2; Q8IUJ3; Q8IUJ4; Q8IZG2; Q8NEY7; Q9UPP9" "" "" "0" "0" "1.024" "1.116" "1.064" "1.052" "1.088" "1.045" "1.045" "1.098" "0.893" "623.5" "638.7" "696.0" "663.7" "655.8" "678.1" "651.7" "651.5" "684.7" "556.7" "" "" "" "" "" "" "" "" "" "" "562.8" "492.7" "538.3" "446.9" "547.0" "578.8" "552.8" "471.5" "461.8" "556.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124389197736880790" "False" "High" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "0.000" "False" "69.679" "38" "13" "51" "13" "334" "36.4" "7.36" "143.02" "13" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Gluconeogenesis" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; HDAC6 interactions in the central nervous system" "10" "0" "1.036" "1.100" "0.961" "1.029" "1.107" "1.065" "1.050" "1.091" "0.728" "2140.8" "2218.6" "2354.7" "2058.1" "2201.9" "2370.2" "2279.8" "2247.4" "2334.8" "1558.0" "" "" "" "" "" "" "" "" "" "" "1932.4" "1711.3" "1821.2" "1385.9" "1836.7" "2023.0" "1933.9" "1626.5" "1574.8" "1558.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8904894331141024633" "False" "High" "IsMasterProtein" "Q04726" "Transducin-like enhancer protein 3 OS=Homo sapiens OX=9606 GN=TLE3 PE=1 SV=2" "0.000" "False" "69.679" "18" "12" "19" "8" "772" "83.4" "7.20" "64.68" "12" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7090" "ENSG00000140332" "TLE3" "B4DPT0; E9PD64; F8W964; hsa:7090; Q04726; Q6PI57; Q8IVV6; Q8WVR2; Q9HCM5" "Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes" "White fat cell differentiation" "5" "4" "0.933" "1.028" "0.946" "1.000" "1.057" "1.029" "1.030" "1.017" "0.841" "1300.9" "1213.9" "1337.5" "1230.2" "1300.2" "1374.5" "1337.9" "1340.4" "1322.8" "1094.4" "" "" "" "" "" "" "" "" "" "" "1174.2" "936.3" "1034.5" "828.4" "1084.6" "1173.2" "1134.9" "970.0" "892.2" "1094.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6241342632728061571" "False" "High" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "0.000" "False" "69.409" "28" "13" "19" "13" "476" "54.8" "6.61" "57.58" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "mRNA processing; 15q25 copy number variation" "5" "0" "0.991" "1.063" "1.035" "1.028" "1.076" "1.004" "1.036" "1.064" "0.847" "1252.5" "1241.5" "1331.0" "1295.9" "1287.6" "1347.1" "1257.5" "1297.0" "1333.2" "1060.8" "" "" "" "" "" "" "" "" "" "" "1130.6" "957.6" "1029.4" "872.7" "1074.1" "1149.8" "1066.7" "938.7" "899.2" "1060.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-16918109513615625" "False" "High" "IsMasterProtein" "P51149" "Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1" "0.000" "False" "69.356" "43" "8" "16" "8" "207" "23.5" "6.70" "54.62" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "7879" "ENSG00000075785" "RAB7A" "A8K3V6; hsa:7879; P51149; Q9NWJ0; Q9UPB0" "RHOG GTPase cycle; TBC/RABGAPs; Neutrophil degranulation; Prevention of phagosomal-lysosomal fusion; RAB geranylgeranylation; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAB GEFs exchange GTP for GDP on RABs; MHC class II antigen presentation; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Suppression of autophagy; RHOH GTPase cycle" "Ebola virus infection in host; Autosomal recessive osteopetrosis pathways; Intracellular trafficking proteins involved in CMT neuropathy" "20" "0" "0.993" "1.197" "1.017" "1.023" "1.242" "1.069" "1.049" "1.176" "0.752" "671.3" "666.6" "803.2" "682.7" "686.9" "833.7" "717.8" "704.1" "789.2" "504.6" "" "" "" "" "" "" "" "" "" "" "605.9" "514.1" "621.3" "459.7" "573.0" "711.6" "608.9" "509.6" "532.3" "504.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8527092773428768711" "False" "High" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "0.000" "False" "69.240" "31" "10" "18" "10" "401" "44.2" "5.21" "58.40" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane" "Vasopressin-regulated water reabsorption" "12" "0" "0.966" "0.987" "1.080" "0.936" "0.993" "0.990" "0.995" "1.018" "1.154" "739.8" "714.8" "730.1" "799.2" "692.6" "734.3" "732.1" "736.2" "753.1" "853.7" "" "" "" "" "" "" "" "" "" "" "667.8" "551.3" "564.7" "538.2" "577.7" "626.7" "621.0" "532.8" "508.0" "853.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877327812570757942" "False" "High" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "0.000" "False" "69.109" "12" "11" "17" "11" "870" "98.0" "7.44" "57.27" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Recycling pathway of L1; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "14" "0" "1.035" "0.803" "1.010" "1.013" "0.798" "0.991" "0.956" "0.836" "1.003" "1162.0" "1203.1" "932.9" "1173.8" "1177.2" "927.6" "1151.3" "1111.0" "971.7" "1165.6" "" "" "" "" "" "" "" "" "" "" "1048.9" "928.0" "721.5" "790.5" "982.0" "791.7" "976.6" "804.0" "655.4" "1165.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288023909312929848" "False" "High" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "0.000" "False" "69.077" "24" "14" "36" "10" "558" "63.1" "8.32" "109.71" "14" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "Glycolysis; Gluconeogenesis; Neutrophil degranulation; TP53 Regulates Metabolic Genes" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "13" "4" "0.990" "1.074" "1.025" "1.037" "1.093" "1.048" "1.022" "1.096" "0.724" "2725.8" "2699.3" "2927.4" "2793.6" "2827.3" "2979.2" "2856.7" "2785.0" "2987.6" "1974.5" "" "" "" "" "" "" "" "" "" "" "2460.5" "2082.1" "2264.1" "1881.2" "2358.5" "2542.8" "2423.3" "2015.5" "2015.1" "1974.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8925362845928829320" "False" "High" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "0.000" "False" "69.001" "17" "12" "24" "12" "717" "82.9" "8.12" "81.76" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "1.011" "1.164" "0.978" "0.996" "1.138" "1.015" "0.999" "1.156" "0.853" "1131.6" "1144.3" "1317.2" "1106.9" "1127.1" "1288.1" "1148.8" "1130.2" "1307.9" "965.5" "" "" "" "" "" "" "" "" "" "" "1021.4" "882.7" "1018.7" "745.4" "940.2" "1099.5" "974.5" "817.9" "882.1" "965.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5829960447854698720" "False" "High" "IsMasterProtein" "O43399" "Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2" "0.000" "False" "68.914" "42" "7" "23" "7" "206" "22.2" "5.36" "83.12" "7" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf04201" "7165" "ENSG00000101150" "TPD52L2" "B4DPJ6; E1P5G7; hsa:7165; O43398; O43399; Q5JWU5; Q5JWU6; Q5JWU8; Q5U0E0; Q9H3Z6" "" "" "0" "0" "0.938" "0.829" "0.946" "0.920" "0.806" "0.964" "1.054" "0.802" "0.743" "1565.6" "1468.3" "1297.2" "1480.8" "1440.4" "1262.2" "1508.6" "1650.2" "1255.1" "1162.6" "" "" "" "" "" "" "" "" "" "" "1413.2" "1132.5" "1003.3" "997.1" "1201.6" "1077.3" "1279.7" "1194.3" "846.5" "1162.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6102726942936219024" "False" "High" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "0.000" "False" "68.582" "16" "24" "33" "24" "1382" "166.5" "6.79" "89.34" "24" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; NF1 copy number variation syndrome" "9" "0" "0.936" "0.987" "0.985" "1.004" "0.923" "0.946" "0.783" "0.974" "3.447" "1276.8" "1195.2" "1260.6" "1258.0" "1281.7" "1178.5" "1207.5" "1000.1" "1243.7" "4401.2" "" "" "" "" "" "" "" "" "" "" "1152.5" "921.9" "975.0" "847.1" "1069.2" "1005.9" "1024.3" "723.8" "838.8" "4401.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2779381262289932464" "False" "High" "IsMasterProtein" "P17655" "Calpain-2 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN2 PE=1 SV=6" "0.000" "False" "68.499" "19" "11" "17" "11" "700" "79.9" "4.98" "56.74" "11" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00648, Pf01067, Pf13833" "824" "ENSG00000162909" "CAPN2" "A6NDG7; B7ZA96; E7ES58; hsa:824; P17655; Q16738; Q6PJT3; Q8WU26; Q9HBB1" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Focal adhesion; VEGFA-VEGFR2 signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "8" "0" "0.939" "1.001" "0.999" "0.996" "0.984" "0.975" "0.993" "0.968" "0.766" "1145.5" "1075.4" "1146.5" "1144.6" "1140.6" "1126.9" "1116.8" "1137.0" "1108.3" "877.3" "" "" "" "" "" "" "" "" "" "" "1034.0" "829.5" "886.8" "770.8" "951.4" "961.8" "947.4" "822.8" "747.6" "877.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790717896449630852" "False" "High" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "0.000" "False" "68.228" "9" "10" "16" "10" "1303" "140.2" "6.27" "54.13" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "1.000" "1.148" "0.977" "0.991" "1.073" "1.010" "0.946" "1.048" "0.722" "934.3" "933.9" "1072.3" "913.0" "926.0" "1002.9" "943.5" "884.2" "979.5" "674.4" "" "" "" "" "" "" "" "" "" "" "843.4" "720.4" "829.4" "614.8" "772.4" "856.0" "800.3" "639.9" "660.6" "674.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5207555211981118816" "False" "High" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "0.000" "False" "68.207" "21" "13" "15" "13" "767" "86.4" "6.77" "47.69" "13" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.907" "0.864" "1.179" "0.933" "0.827" "0.978" "0.690" "0.888" "6.019" "504.7" "457.9" "436.1" "595.3" "470.8" "417.2" "493.4" "348.3" "448.3" "3037.7" "" "" "" "" "" "" "" "" "" "" "455.6" "353.2" "337.3" "400.9" "392.8" "356.1" "418.5" "252.1" "302.3" "3037.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5808192534094495875" "False" "High" "IsMasterProtein" "Q9HC35" "Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3" "0.000" "False" "68.136" "18" "16" "26" "16" "981" "108.8" "6.40" "64.84" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "27436" "ENSG00000143924" "EML4" "A6H8Y6; A6P4T4; A6P4V4; B2RBK3; B2RTW7; B5MCW9; hsa:27436; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9HC35; Q9NV40" "EML4 and NUDC in mitotic spindle formation; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "Non-small cell lung cancer" "4" "0" "0.899" "0.869" "0.898" "0.956" "0.823" "0.867" "0.840" "0.850" "1.537" "859.3" "772.2" "746.5" "771.7" "821.3" "706.8" "744.6" "721.9" "730.6" "1321.1" "" "" "" "" "" "" "" "" "" "" "775.7" "595.7" "577.4" "519.6" "685.1" "603.3" "631.7" "522.4" "492.8" "1321.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "152076562272560972" "False" "High" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "0.000" "False" "68.096" "16" "8" "14" "8" "638" "71.4" "5.20" "59.13" "8" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380; ENSG00000292102" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "HCMV Early Events; Separation of Sister Chromatids; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "23" "0" "1.004" "0.887" "0.998" "0.959" "0.809" "1.037" "0.983" "0.794" "0.820" "1403.7" "1409.4" "1245.7" "1400.3" "1345.9" "1136.2" "1455.2" "1379.7" "1113.9" "1150.7" "" "" "" "" "" "" "" "" "" "" "1267.1" "1087.1" "963.5" "943.0" "1122.7" "969.8" "1234.4" "998.5" "751.3" "1150.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7835862942369075388" "False" "High" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "0.000" "False" "68.041" "35" "10" "48" "3" "285" "32.9" "4.72" "143.82" "10" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Striated Muscle Contraction" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "7" "2" "1.040" "1.111" "1.132" "1.031" "1.095" "1.100" "1.108" "1.146" "0.757" "966.1" "1004.5" "1073.2" "1093.9" "996.1" "1057.4" "1062.3" "1070.3" "1107.6" "730.9" "" "" "" "" "" "" "" "" "" "" "872.1" "774.8" "830.0" "736.6" "830.9" "902.5" "901.1" "774.6" "747.1" "730.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968571585111953171" "False" "High" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "0.000" "False" "68.015" "36" "9" "18" "9" "377" "40.7" "4.79" "62.57" "9" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "64" "0" "1.064" "0.823" "0.967" "1.048" "0.857" "1.021" "0.972" "0.808" "0.714" "1266.8" "1348.3" "1042.0" "1225.3" "1327.4" "1085.6" "1293.6" "1231.6" "1023.0" "904.9" "" "" "" "" "" "" "" "" "" "" "1143.5" "1040.0" "805.9" "825.1" "1107.3" "926.6" "1097.3" "891.3" "690.0" "904.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5136159273712408888" "False" "High" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "0.000" "False" "67.998" "27" "12" "22" "11" "411" "46.8" "6.73" "78.35" "12" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543; ENSG00000291508" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "TAR syndrome" "11" "0" "1.046" "0.707" "0.987" "1.007" "0.752" "1.012" "1.004" "0.726" "0.706" "1363.4" "1426.3" "964.0" "1345.0" "1372.6" "1024.8" "1380.4" "1369.4" "989.3" "962.5" "" "" "" "" "" "" "" "" "" "" "1230.7" "1100.2" "745.6" "905.7" "1145.0" "874.7" "1170.9" "991.0" "667.2" "962.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200158126373336546" "False" "High" "IsMasterProtein" "Q6IBS0" "Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2" "0.000" "False" "67.836" "32" "9" "19" "8" "349" "39.5" "6.84" "70.03" "9" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "11344" "ENSG00000247596" "TWF2" "hsa:11344; Q6IBS0; Q9Y3F5" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "1" "1.014" "1.134" "1.011" "1.035" "1.141" "0.995" "0.992" "1.132" "0.954" "1151.1" "1166.7" "1304.9" "1163.4" "1190.9" "1313.2" "1145.2" "1141.6" "1302.9" "1098.1" "" "" "" "" "" "" "" "" "" "" "1039.0" "900.0" "1009.2" "783.4" "993.4" "1120.8" "971.5" "826.2" "878.8" "1098.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1761258682097812184" "False" "High" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "0.000" "False" "67.833" "17" "6" "11" "6" "450" "50.8" "7.43" "47.31" "6" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "0.996" "0.907" "0.969" "0.991" "0.983" "0.989" "1.019" "0.953" "0.744" "1163.0" "1157.9" "1054.9" "1127.3" "1152.8" "1142.8" "1150.6" "1185.0" "1108.8" "864.8" "" "" "" "" "" "" "" "" "" "" "1049.8" "893.1" "815.9" "759.1" "961.6" "975.4" "976.0" "857.5" "747.9" "864.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986296192720168781" "False" "High" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "0.000" "False" "67.759" "29" "9" "18" "9" "370" "40.4" "7.66" "60.81" "9" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "7" "0" "0.987" "1.026" "0.980" "1.014" "1.073" "0.981" "1.051" "1.090" "0.701" "1276.3" "1259.9" "1309.7" "1250.9" "1293.6" "1369.9" "1251.5" "1341.9" "1391.4" "895.1" "" "" "" "" "" "" "" "" "" "" "1152.1" "971.8" "1012.9" "842.3" "1079.1" "1169.2" "1061.6" "971.1" "938.5" "895.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3827413943900730422" "False" "High" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "0.000" "False" "67.691" "15" "10" "21" "10" "641" "70.0" "8.38" "67.80" "10" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "mRNA Splicing - Major Pathway" "" "1" "0" "1.026" "1.117" "1.043" "1.014" "1.103" "0.973" "1.016" "1.074" "0.677" "1734.7" "1780.4" "1938.1" "1808.9" "1759.4" "1912.6" "1688.5" "1763.0" "1862.5" "1174.9" "" "" "" "" "" "" "" "" "" "" "1565.9" "1373.3" "1499.0" "1218.1" "1467.6" "1632.4" "1432.3" "1275.9" "1256.2" "1174.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2598946853791074460" "False" "High" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "0.000" "False" "67.616" "32" "10" "28" "9" "367" "40.5" "8.90" "92.76" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "Protein hydroxylation" "" "1" "0" "0.988" "0.851" "0.989" "0.961" "0.832" "1.018" "0.969" "0.824" "0.757" "1342.3" "1326.0" "1142.7" "1327.4" "1290.5" "1116.5" "1366.1" "1300.8" "1105.9" "1015.6" "" "" "" "" "" "" "" "" "" "" "1211.7" "1022.8" "883.8" "893.9" "1076.5" "953.0" "1158.8" "941.4" "745.9" "1015.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3705631994362769923" "False" "High" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "0.000" "False" "67.239" "26" "14" "25" "14" "515" "59.2" "6.84" "78.99" "14" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "16" "0" "1.040" "0.805" "0.968" "1.014" "0.862" "0.992" "1.008" "0.829" "0.774" "1524.0" "1584.4" "1226.9" "1474.9" "1544.6" "1313.1" "1512.1" "1535.7" "1263.3" "1179.7" "" "" "" "" "" "" "" "" "" "" "1375.7" "1222.1" "949.0" "993.2" "1288.5" "1120.8" "1282.7" "1111.4" "852.1" "1179.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3818146926309850822" "False" "High" "IsMasterProtein" "O95671" "Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3" "0.000" "False" "67.132" "23" "12" "17" "12" "621" "68.8" "6.07" "56.98" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf00891, Pf02545, Pf16864" "8623" "ENSG00000169093; ENSG00000292339" "ASMTL" "B4DX75; F5GXH4; hsa:8623; J3JS33; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6" "" "" "0" "0" "1.039" "0.724" "0.850" "0.901" "0.715" "0.910" "0.907" "0.685" "0.818" "1054.0" "1095.4" "763.2" "896.2" "949.7" "753.3" "958.9" "956.0" "722.2" "861.8" "" "" "" "" "" "" "" "" "" "" "951.4" "845.0" "590.3" "603.5" "792.2" "642.9" "813.4" "691.8" "487.1" "861.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320563030437256339" "False" "High" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "0.000" "False" "67.074" "33" "8" "14" "8" "272" "28.2" "6.28" "56.92" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "1.045" "0.967" "0.976" "1.071" "0.966" "1.032" "1.050" "0.991" "0.554" "881.4" "921.2" "852.6" "860.4" "944.3" "851.1" "909.7" "925.4" "873.4" "488.4" "" "" "" "" "" "" "" "" "" "" "795.6" "710.6" "659.4" "579.4" "787.7" "726.4" "771.6" "669.7" "589.1" "488.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463755477932393031" "False" "High" "IsMasterProtein" "Q9H4M9" "EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2" "0.000" "False" "67.048" "26" "13" "28" "9" "534" "60.6" "6.83" "76.72" "13" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "10938" "ENSG00000110047" "EHD1" "hsa:10938; O14611; Q2M3Q4; Q9H4M9; Q9UNR3" "Factors involved in megakaryocyte development and platelet production" "Insulin signaling" "2" "5" "0.978" "0.790" "0.938" "1.052" "0.802" "0.976" "0.995" "0.816" "0.853" "745.8" "729.7" "589.6" "699.4" "784.9" "597.8" "727.8" "741.9" "609.0" "636.1" "" "" "" "" "" "" "" "" "" "" "673.3" "562.8" "456.0" "470.9" "654.8" "510.2" "617.4" "536.9" "410.7" "636.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110306690791428834" "False" "High" "IsMasterProtein" "P29218" "Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1" "0.000" "False" "67.017" "30" "7" "14" "7" "277" "30.2" "5.26" "51.40" "7" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf00459" "3612" "ENSG00000133731" "IMPA1" "B2R733; B4DLN3; B7Z6Q4; J3KQT7; P29218; Q9UK71" "Synthesis of IP2, IP, and Ins in the cytosol" "" "1" "0" "0.965" "1.129" "1.028" "1.002" "1.113" "1.015" "1.038" "1.126" "0.729" "723.4" "698.2" "816.4" "743.3" "724.5" "804.8" "734.4" "750.9" "814.7" "527.4" "" "" "" "" "" "" "" "" "" "" "653.0" "538.5" "631.4" "500.5" "604.4" "686.9" "623.0" "543.4" "549.5" "527.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6529775950404904251" "False" "High" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "0.000" "False" "67.005" "17" "13" "19" "13" "864" "94.2" "5.11" "60.70" "13" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "EGF/EGFR signaling pathway" "4" "0" "1.037" "1.227" "1.112" "0.995" "1.247" "1.041" "0.990" "1.270" "1.685" "673.9" "698.7" "826.7" "749.7" "670.6" "840.7" "701.7" "667.3" "855.8" "1135.6" "" "" "" "" "" "" "" "" "" "" "608.3" "538.9" "639.4" "504.9" "559.4" "717.5" "595.3" "482.9" "577.2" "1135.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421674880825804013" "False" "High" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "0.000" "False" "66.966" "26" "5" "23" "5" "240" "26.7" "5.20" "90.65" "5" "" "other membranes" "other molecular function" "Pf21008" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "RHOD GTPase cycle" "" "1" "0" "0.977" "1.010" "0.957" "0.928" "1.013" "0.897" "0.962" "0.971" "0.778" "1576.1" "1539.2" "1591.1" "1508.7" "1462.0" "1597.3" "1413.1" "1515.6" "1531.1" "1225.8" "" "" "" "" "" "" "" "" "" "" "1422.7" "1187.2" "1230.6" "1016.0" "1219.5" "1363.3" "1198.7" "1096.8" "1032.7" "1225.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490413544944086937" "False" "High" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "0.000" "False" "66.954" "46" "6" "18" "6" "153" "16.9" "6.60" "79.49" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "2" "0" "1.062" "0.909" "1.109" "0.947" "0.881" "0.950" "0.932" "0.949" "0.850" "508.7" "540.3" "462.3" "564.2" "481.8" "448.2" "483.4" "474.0" "482.5" "432.5" "" "" "" "" "" "" "" "" "" "" "459.2" "416.7" "357.6" "379.9" "401.9" "382.6" "410.1" "343.0" "325.4" "432.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6708028902102911891" "False" "High" "IsMasterProtein" "P21281" "V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3" "0.000" "False" "66.725" "20" "9" "28" "9" "511" "56.5" "5.81" "82.34" "9" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "526" "ENSG00000147416" "ATP6V1B2" "B2R5Z3; D3DSQ5; hsa:526; P21281; Q14544; Q15859; Q96IR0" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "" "5" "0" "0.925" "1.000" "0.991" "0.968" "1.030" "1.010" "0.993" "1.036" "0.760" "2037.8" "1884.5" "2038.3" "2019.8" "1972.5" "2098.5" "2058.6" "2024.5" "2111.6" "1549.8" "" "" "" "" "" "" "" "" "" "" "1839.5" "1453.6" "1576.5" "1360.1" "1645.4" "1791.1" "1746.3" "1465.1" "1424.2" "1549.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1669697587989024487" "False" "High" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "0.000" "False" "66.578" "38" "8" "22" "8" "271" "31.3" "4.94" "83.89" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "Ub-specific processing proteases; Ovarian tumor domain proteases" "" "2" "0" "0.952" "1.028" "0.908" "0.960" "1.065" "0.914" "1.014" "1.070" "0.867" "1165.9" "1110.5" "1198.5" "1058.5" "1119.6" "1241.6" "1065.5" "1181.9" "1247.9" "1010.7" "" "" "" "" "" "" "" "" "" "" "1052.5" "856.6" "927.0" "712.8" "933.9" "1059.7" "903.8" "855.4" "841.7" "1010.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5185588165699995097" "False" "High" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "0.000" "False" "66.467" "39" "7" "26" "6" "206" "22.2" "9.38" "104.75" "7" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "" "Orexin receptor pathway" "1" "1" "1.057" "1.131" "1.063" "1.145" "1.056" "1.153" "1.183" "1.019" "0.769" "1253.3" "1325.2" "1417.0" "1332.2" "1434.8" "1323.1" "1445.3" "1483.0" "1277.7" "963.3" "" "" "" "" "" "" "" "" "" "" "1131.3" "1022.2" "1095.9" "897.1" "1196.9" "1129.3" "1226.0" "1073.2" "861.8" "963.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7380698507310522757" "False" "High" "IsMasterProtein" "P41227" "N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1" "0.000" "False" "66.357" "39" "9" "28" "9" "235" "26.4" "5.64" "93.08" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "8260" "ENSG00000102030" "NAA10" "A6NM98; hsa:8260; P41227" "" "" "0" "0" "0.989" "1.053" "0.985" "0.967" "0.994" "0.939" "0.983" "1.017" "0.719" "1955.6" "1934.9" "2058.6" "1925.8" "1891.6" "1944.4" "1835.8" "1923.3" "1988.4" "1405.9" "" "" "" "" "" "" "" "" "" "" "1765.2" "1492.5" "1592.2" "1296.8" "1577.9" "1659.6" "1557.3" "1391.8" "1341.1" "1405.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243510454319930112" "False" "High" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "0.000" "False" "66.346" "18" "12" "23" "12" "734" "82.2" "8.37" "68.54" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication" "10" "0" "1.031" "0.853" "1.052" "1.050" "0.817" "1.084" "1.054" "0.877" "0.908" "1016.8" "1047.9" "867.2" "1069.9" "1067.3" "830.2" "1102.5" "1071.6" "891.4" "923.5" "" "" "" "" "" "" "" "" "" "" "917.8" "808.3" "670.7" "720.5" "890.3" "708.6" "935.3" "775.5" "601.2" "923.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835450799000805125" "False" "High" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "0.000" "False" "65.998" "19" "15" "22" "15" "819" "93.4" "5.72" "67.79" "15" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "ISG15 antiviral mechanism; Regulation of HSF1-mediated heat shock response; HCMV Early Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "0.992" "0.841" "1.082" "0.928" "0.885" "0.991" "0.886" "0.872" "1.795" "638.6" "633.6" "537.0" "690.7" "592.6" "565.1" "633.2" "565.8" "557.1" "1146.2" "" "" "" "" "" "" "" "" "" "" "576.5" "488.7" "415.3" "465.1" "494.3" "482.3" "537.1" "409.5" "375.8" "1146.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5620405547330282270" "False" "High" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "0.000" "False" "65.968" "18" "14" "24" "13" "671" "74.3" "7.49" "77.09" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "1.094" "1.032" "1.048" "1.004" "1.003" "0.985" "1.015" "1.123" "1.013" "1387.8" "1518.1" "1432.7" "1454.9" "1393.3" "1392.5" "1366.5" "1409.3" "1558.3" "1405.7" "" "" "" "" "" "" "" "" "" "" "1252.8" "1171.0" "1108.1" "979.7" "1162.2" "1188.5" "1159.2" "1019.9" "1051.0" "1405.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6973941838255417452" "False" "High" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "0.000" "False" "65.798" "21" "14" "19" "14" "900" "101.1" "6.16" "57.74" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "1.036" "0.807" "0.926" "0.990" "0.778" "0.966" "0.807" "0.820" "2.803" "639.9" "662.9" "516.3" "592.7" "633.3" "497.7" "617.8" "516.5" "524.7" "1793.7" "" "" "" "" "" "" "" "" "" "" "577.6" "511.3" "399.3" "399.1" "528.3" "424.8" "524.1" "373.8" "353.9" "1793.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7305935062523076867" "False" "High" "IsMasterProtein" "Q9Y3Z3" "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2" "0.000" "False" "65.733" "22" "13" "16" "13" "626" "72.2" "7.14" "55.48" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01966, Pf07647" "25939" "ENSG00000101347" "SAMHD1" "B4E2A5; E1P5V2; hsa:25939; Q5JXG8; Q8N491; Q9H004; Q9H005; Q9H3U9; Q9Y3Z3" "Interferon alpha/beta signaling; Nucleotide catabolism" "" "2" "0" "1.031" "0.787" "1.007" "1.044" "0.835" "1.073" "1.014" "0.917" "0.879" "938.1" "967.1" "738.6" "944.6" "979.3" "783.2" "1006.3" "950.9" "859.9" "825.0" "" "" "" "" "" "" "" "" "" "" "846.8" "746.0" "571.3" "636.1" "816.9" "668.4" "853.6" "688.1" "580.0" "825.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4874670657009698466" "False" "High" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "0.000" "False" "65.643" "8" "20" "23" "20" "2335" "273.4" "8.84" "66.35" "20" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.043" "0.836" "0.968" "0.998" "0.816" "0.985" "0.943" "0.834" "1.153" "931.6" "971.7" "778.7" "901.5" "929.4" "759.9" "918.1" "878.9" "777.4" "1073.7" "" "" "" "" "" "" "" "" "" "" "840.9" "749.5" "602.3" "607.1" "775.3" "648.6" "778.8" "636.0" "524.4" "1073.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7175242905837588229" "False" "High" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "0.000" "False" "65.639" "22" "10" "16" "10" "527" "58.0" "6.43" "59.55" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "0" "1.086" "0.984" "1.010" "1.112" "1.011" "1.120" "1.062" "1.077" "1.850" "675.8" "734.0" "665.3" "682.8" "751.3" "683.4" "756.6" "718.0" "728.0" "1250.4" "" "" "" "" "" "" "" "" "" "" "610.0" "566.2" "514.6" "459.8" "626.7" "583.3" "641.8" "519.6" "491.0" "1250.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119671646432562357" "False" "High" "IsMasterProtein" "P13929" "Beta-enolase OS=Homo sapiens OX=9606 GN=ENO3 PE=1 SV=5" "0.000" "False" "65.636" "20" "6" "28" "3" "434" "47.0" "7.71" "97.67" "6" "other metabolic processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00113, Pf03952" "2027" "ENSG00000108515" "ENO3" "B4DUI6; B4DUM6; D3DTL2; E7ENK8; hsa:2027; P13929; Q96AE2" "Glycolysis; Gluconeogenesis" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "0" "0.864" "0.990" "0.813" "0.887" "0.974" "0.854" "0.655" "1.192" "0.757" "199.2" "172.0" "197.2" "162.0" "176.6" "194.0" "170.0" "130.5" "237.5" "150.7" "" "" "" "" "" "" "" "" "" "" "179.8" "132.7" "152.5" "109.1" "147.3" "165.6" "144.2" "94.4" "160.2" "150.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3363379489977265255" "False" "High" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "0.000" "False" "65.618" "49" "6" "26" "6" "154" "15.9" "6.13" "85.84" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation; HDAC6 interactions in the central nervous system" "17" "0" "1.088" "1.290" "0.901" "1.035" "1.092" "1.042" "1.155" "1.040" "0.593" "1189.6" "1293.9" "1534.5" "1071.6" "1231.0" "1299.6" "1239.1" "1374.3" "1236.6" "705.1" "" "" "" "" "" "" "" "" "" "" "1073.8" "998.0" "1186.9" "721.6" "1026.8" "1109.2" "1051.1" "994.6" "834.1" "705.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105726009165371323" "False" "High" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "0.000" "False" "65.588" "33" "11" "26" "11" "350" "37.9" "8.73" "73.76" "11" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "4" "0" "1.012" "0.924" "1.099" "0.991" "0.909" "1.023" "0.930" "0.932" "0.679" "1324.4" "1340.1" "1224.3" "1455.9" "1312.3" "1204.0" "1355.2" "1231.9" "1234.8" "899.0" "" "" "" "" "" "" "" "" "" "" "1195.5" "1033.6" "946.9" "980.4" "1094.7" "1027.7" "1149.6" "891.5" "832.9" "899.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128416838288873001" "False" "High" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "0.000" "False" "65.567" "30" "9" "23" "9" "359" "39.2" "6.65" "72.29" "9" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Orexin receptor pathway" "8" "0" "1.063" "0.849" "1.051" "1.008" "0.820" "0.991" "0.959" "0.837" "0.906" "977.1" "1038.3" "830.0" "1027.2" "985.2" "801.4" "968.5" "937.2" "817.8" "885.1" "" "" "" "" "" "" "" "" "" "" "882.0" "800.9" "642.0" "691.7" "821.8" "684.0" "821.6" "678.2" "551.6" "885.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-199396300438152648" "False" "High" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "0.000" "False" "65.567" "36" "11" "33" "11" "255" "28.4" "5.33" "102.92" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; Regulation of RUNX3 expression and activity; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.961" "1.151" "0.907" "1.005" "1.083" "1.043" "1.013" "1.059" "0.832" "2405.8" "2311.7" "2769.8" "2182.4" "2417.5" "2605.4" "2508.6" "2436.9" "2548.8" "2000.8" "" "" "" "" "" "" "" "" "" "" "2171.7" "1783.1" "2142.2" "1469.6" "2016.6" "2223.8" "2128.0" "1763.5" "1719.1" "2000.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8565814559741767915" "False" "High" "IsMasterProtein" "Q16566" "Calcium/calmodulin-dependent protein kinase type IV OS=Homo sapiens OX=9606 GN=CAMK4 PE=1 SV=1" "0.000" "False" "65.509" "28" "13" "17" "12" "473" "51.9" "5.82" "53.09" "13" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "814" "ENSG00000152495" "CAMK4" "D3DSZ7; hsa:814; Q16566" "Transcriptional activation of mitochondrial biogenesis; Regulation of MECP2 expression and activity; Negative regulation of NMDA receptor-mediated neuronal transmission; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; Loss of phosphorylation of MECP2 at T308" "Energy metabolism; Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Mitochondrial gene expression; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; CAMKK2 pathway; Neuroinflammation and glutamatergic signaling; Hippocampal synaptogenesis and neurogenesis; Calcium regulation in cardiac cells" "17" "1" "0.999" "0.831" "1.057" "1.033" "0.855" "1.029" "1.090" "0.849" "0.878" "876.6" "875.6" "728.2" "926.3" "905.7" "749.7" "902.3" "955.1" "744.1" "769.3" "" "" "" "" "" "" "" "" "" "" "791.3" "675.4" "563.2" "623.8" "755.5" "639.9" "765.4" "691.2" "501.9" "769.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2495561624923528868" "False" "High" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=3" "0.000" "False" "65.439" "12" "12" "19" "3" "949" "104.5" "5.06" "66.29" "12" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "162" "ENSG00000100280" "AP1B1" "C9JRD1; F8WDL0; hsa:162; P78436; Q10567; Q20WL3; Q86X54" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "6" "0.945" "1.096" "0.941" "1.050" "1.142" "0.951" "0.927" "1.128" "1.268" "944.4" "892.2" "1034.9" "888.5" "991.9" "1078.1" "897.9" "875.1" "1064.9" "1197.2" "" "" "" "" "" "" "" "" "" "" "852.5" "688.2" "800.4" "598.3" "827.4" "920.2" "761.7" "633.3" "718.3" "1197.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-109273256828227415" "False" "High" "IsMasterProtein" "Q07866" "Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2" "0.000" "False" "65.438" "21" "12" "20" "11" "573" "65.3" "6.20" "64.92" "12" "cell adhesion;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00515, Pf13374, Pf13424" "3831" "ENSG00000126214" "KLC1" "A6NF62; F8VTM4; hsa:3831; Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; IL-18 signaling pathway; Alzheimer's disease" "8" "0" "1.036" "0.754" "0.929" "1.033" "0.854" "0.951" "0.989" "0.798" "0.818" "821.6" "851.3" "619.5" "763.0" "848.4" "701.8" "781.7" "812.9" "655.5" "672.1" "" "" "" "" "" "" "" "" "" "" "741.7" "656.7" "479.1" "513.8" "707.7" "599.0" "663.1" "588.3" "442.1" "672.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4912222715256496910" "False" "High" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "0.000" "False" "65.432" "19" "12" "22" "6" "633" "70.9" "8.13" "73.27" "12" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "3" "0" "1.001" "1.001" "1.042" "1.072" "1.032" "0.949" "0.671" "1.042" "3.887" "317.7" "318.1" "318.0" "331.2" "340.5" "327.8" "301.6" "213.3" "331.0" "1235.1" "" "" "" "" "" "" "" "" "" "" "286.8" "245.3" "246.0" "223.0" "284.0" "279.8" "255.8" "154.3" "223.2" "1235.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4468909642596951639" "False" "High" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "0.000" "False" "65.342" "15" "16" "20" "16" "963" "109.9" "5.57" "64.87" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "0.964" "0.739" "1.004" "0.979" "0.772" "1.030" "0.928" "0.770" "1.791" "1644.6" "1585.2" "1215.9" "1650.7" "1610.4" "1269.4" "1693.5" "1526.3" "1266.3" "2945.5" "" "" "" "" "" "" "" "" "" "" "1484.6" "1222.7" "940.4" "1111.6" "1343.4" "1083.5" "1436.5" "1104.6" "854.1" "2945.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5341813448089902722" "False" "High" "IsMasterProtein" "P16885" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4" "0.000" "False" "65.104" "13" "16" "20" "15" "1265" "147.8" "6.64" "62.24" "16" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf16457" "5336" "ENSG00000197943" "PLCG2" "D3DUL3; hsa:5336; P16885; Q3ZTS2; Q59H45; Q969T5" "Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; DAP12 signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family" "Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; GDNF signaling; 2q13 copy number variation syndrome; ErbB signaling pathway" "30" "0" "0.968" "0.977" "1.199" "1.003" "0.932" "1.031" "0.507" "0.960" "8.575" "492.0" "476.3" "480.8" "590.1" "493.7" "458.7" "507.3" "249.5" "472.4" "4219.0" "" "" "" "" "" "" "" "" "" "" "444.1" "367.4" "371.9" "397.4" "411.8" "391.5" "430.4" "180.5" "318.6" "4219.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320605404870657198" "False" "High" "IsMasterProtein" "Q8NC51" "SERPINE1 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "0.000" "False" "65.015" "25" "9" "25" "9" "408" "44.9" "8.65" "81.07" "9" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "1" "0" "0.943" "1.191" "0.985" "1.018" "1.118" "1.061" "1.147" "1.123" "0.426" "2023.5" "1907.6" "2410.4" "1992.7" "2060.7" "2262.2" "2146.4" "2321.6" "2271.6" "861.1" "" "" "" "" "" "" "" "" "" "" "1826.6" "1471.4" "1864.3" "1341.9" "1719.0" "1930.8" "1820.7" "1680.1" "1532.2" "861.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3873794915793825420" "False" "High" "IsMasterProtein" "Q9BYT8" "Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1" "0.000" "False" "64.908" "13" "8" "20" "8" "704" "80.6" "6.64" "62.02" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf01432" "57486" "ENSG00000123213" "NLN" "hsa:57486; Q9BYT8; Q9ULJ4" "Peptide ligand-binding receptors" "" "1" "0" "0.981" "1.085" "0.953" "0.858" "1.097" "0.874" "0.936" "0.924" "0.755" "807.1" "791.6" "875.8" "768.9" "692.4" "885.4" "705.6" "755.8" "745.4" "609.6" "" "" "" "" "" "" "" "" "" "" "728.6" "610.6" "677.3" "517.8" "577.6" "755.7" "598.6" "547.0" "502.8" "609.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7906499553592381403" "False" "High" "IsMasterProtein" "Q7Z5L9" "Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens OX=9606 GN=IRF2BP2 PE=1 SV=2" "0.000" "False" "64.845" "26" "13" "19" "13" "587" "61.0" "8.69" "71.28" "13" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf11261" "359948" "ENSG00000168264" "IRF2BP2" "B1AM35; B1AM36; hsa:359948; Q6P083; Q7Z5L8; Q7Z5L9; Q8N351; Q8WUH8" "" "" "0" "0" "1.000" "0.910" "0.976" "1.002" "0.933" "1.000" "1.042" "0.940" "0.861" "1436.6" "1436.4" "1307.4" "1402.0" "1439.6" "1341.0" "1436.6" "1496.9" "1349.9" "1237.1" "" "" "" "" "" "" "" "" "" "" "1296.8" "1108.0" "1011.2" "944.1" "1200.9" "1144.6" "1218.7" "1083.3" "910.5" "1237.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681400762000750361" "False" "High" "IsMasterProtein" "O60749" "Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2" "0.000" "False" "64.834" "24" "11" "21" "8" "519" "58.4" "5.12" "64.97" "11" "cell organization and biogenesis;transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6643" "ENSG00000205302" "SNX2" "B3KN44; B4DEK4; B7Z408; hsa:6643; O43650; O60749; P82862; Q53XK8; Q597H6; Q9BTS8" "Golgi Associated Vesicle Biogenesis" "" "1" "3" "1.009" "0.931" "0.864" "0.926" "0.908" "0.966" "0.879" "0.839" "1.040" "1128.0" "1138.3" "1050.2" "974.6" "1044.6" "1024.6" "1089.1" "991.5" "946.6" "1173.4" "" "" "" "" "" "" "" "" "" "" "1018.2" "878.0" "812.3" "656.3" "871.3" "874.5" "923.9" "717.5" "638.5" "1173.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445993330794884217" "False" "High" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "0.000" "False" "64.700" "31" "17" "19" "17" "528" "59.1" "7.05" "54.46" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Cytosolic tRNA aminoacylation" "Nephrotic syndrome" "2" "0" "0.961" "0.838" "0.987" "0.966" "0.838" "1.005" "0.738" "0.818" "3.853" "648.9" "623.3" "543.6" "640.6" "626.8" "543.9" "652.5" "479.2" "531.0" "2500.4" "" "" "" "" "" "" "" "" "" "" "585.8" "480.8" "420.4" "431.4" "522.8" "464.2" "553.5" "346.8" "358.2" "2500.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169835918379755143" "False" "High" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "0.000" "False" "64.653" "32" "9" "48" "6" "249" "28.6" "4.09" "141.85" "9" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "HuR (ELAVL1) binds and stabilizes mRNA" "IL-18 signaling pathway" "2" "3" "0.986" "1.033" "0.973" "0.955" "1.075" "1.031" "1.024" "1.094" "0.794" "1922.9" "1896.8" "1986.3" "1871.1" "1836.1" "2066.8" "1981.8" "1969.9" "2103.1" "1526.9" "" "" "" "" "" "" "" "" "" "" "1735.8" "1463.1" "1536.3" "1260.0" "1531.6" "1764.0" "1681.1" "1425.6" "1418.5" "1526.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058456233631452436" "False" "High" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "0.000" "False" "64.638" "41" "9" "59" "6" "199" "22.1" "8.13" "173.41" "9" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; HDAC6 interactions in the central nervous system" "9" "1" "0.978" "1.009" "0.956" "1.007" "1.043" "0.995" "0.971" "1.045" "0.720" "2799.4" "2738.6" "2824.3" "2676.1" "2818.7" "2918.4" "2784.2" "2717.9" "2924.5" "2016.5" "" "" "" "" "" "" "" "" "" "" "2527.0" "2112.4" "2184.4" "1802.1" "2351.3" "2490.9" "2361.8" "1966.9" "1972.5" "2016.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135985212415519925" "False" "High" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "0.000" "False" "64.633" "26" "13" "26" "13" "418" "47.3" "5.21" "78.33" "13" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Assembly of the pre-replicative complex; Neddylation; KEAP1-NFE2L2 pathway; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "64" "0" "0.999" "0.778" "1.019" "1.001" "0.817" "1.008" "1.007" "0.786" "0.910" "1598.9" "1596.8" "1244.6" "1629.5" "1601.1" "1306.2" "1612.1" "1610.6" "1256.4" "1454.6" "" "" "" "" "" "" "" "" "" "" "1443.3" "1231.7" "962.6" "1097.3" "1335.6" "1114.9" "1367.5" "1165.5" "847.4" "1454.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6460055541994458794" "False" "High" "IsMasterProtein" "Q14019" "Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3" "0.000" "False" "64.458" "63" "9" "50" "9" "142" "15.9" "5.67" "148.65" "9" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "23406" "ENSG00000103187" "COTL1" "B2RDU3; D3DUL9; hsa:23406; Q14019; Q86XM5" "Neutrophil degranulation" "" "1" "0" "0.991" "1.080" "1.040" "1.029" "1.061" "1.046" "1.049" "1.041" "0.864" "2827.5" "2801.3" "3053.9" "2940.3" "2910.1" "3001.0" "2957.2" "2967.4" "2942.2" "2443.7" "" "" "" "" "" "" "" "" "" "" "2552.3" "2160.8" "2362.0" "1980.0" "2427.5" "2561.4" "2508.5" "2147.5" "1984.5" "2443.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "508361359361041752" "False" "High" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "0.000" "False" "64.405" "36" "4" "15" "4" "183" "20.3" "4.72" "59.52" "4" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "1.090" "1.366" "1.051" "1.110" "1.252" "1.183" "1.185" "1.347" "0.858" "508.8" "554.6" "695.0" "534.7" "564.7" "637.0" "601.7" "602.7" "685.3" "436.4" "" "" "" "" "" "" "" "" "" "" "459.2" "427.8" "537.6" "360.0" "471.0" "543.7" "510.4" "436.2" "462.2" "436.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-294736394566280624" "False" "High" "IsMasterProtein" "Q16204" "Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2" "0.000" "False" "64.296" "24" "11" "20" "11" "474" "53.3" "7.34" "58.93" "11" "cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf09755" "8030" "ENSG00000108091" "CCDC6" "hsa:8030; Q15250; Q16204; Q6GSG7" "" "Retinoblastoma gene in cancer; Mesodermal commitment pathway; 16p11.2 proximal deletion syndrome" "3" "0" "1.083" "0.982" "1.093" "1.056" "0.949" "1.051" "1.125" "1.005" "0.880" "373.8" "405.0" "367.0" "408.5" "394.8" "354.9" "392.9" "420.5" "375.7" "328.8" "" "" "" "" "" "" "" "" "" "" "337.5" "312.4" "283.9" "275.1" "329.3" "302.9" "333.3" "304.3" "253.4" "328.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513185524036398277" "False" "High" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "0.000" "False" "64.237" "25" "13" "26" "13" "528" "60.5" "7.52" "79.36" "13" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "0" "1.084" "0.859" "1.043" "0.980" "0.880" "0.992" "1.052" "0.847" "0.711" "968.2" "1049.2" "831.7" "1009.4" "948.5" "851.7" "960.5" "1018.9" "820.0" "688.4" "" "" "" "" "" "" "" "" "" "" "873.9" "809.3" "643.2" "679.7" "791.2" "726.9" "814.8" "737.3" "553.1" "688.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535897714363242613" "False" "High" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "0.000" "False" "64.221" "25" "9" "31" "9" "361" "41.5" "6.60" "98.72" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "Anchoring of the basal body to the plasma membrane" "2q37 copy number variation syndrome" "2" "0" "1.010" "0.976" "0.966" "0.817" "1.020" "0.843" "0.910" "0.941" "0.757" "1413.3" "1427.5" "1379.5" "1365.7" "1154.5" "1442.1" "1192.1" "1285.6" "1329.6" "1069.2" "" "" "" "" "" "" "" "" "" "" "1275.8" "1101.1" "1067.0" "919.6" "963.0" "1230.8" "1011.3" "930.4" "896.8" "1069.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088102652964782572" "False" "High" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "0.000" "False" "64.156" "17" "10" "18" "6" "644" "70.7" "9.26" "58.84" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "0.955" "0.716" "0.952" "0.953" "0.808" "0.930" "0.916" "0.742" "1.462" "315.8" "301.6" "226.2" "300.7" "300.9" "255.1" "293.5" "289.4" "234.2" "461.6" "" "" "" "" "" "" "" "" "" "" "285.0" "232.7" "174.9" "202.5" "251.0" "217.8" "249.0" "209.4" "158.0" "461.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-885056090803738498" "False" "High" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "0.000" "False" "64.111" "14" "10" "16" "9" "775" "87.7" "7.15" "52.63" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558, Pf20974" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "" "3" "0" "1.037" "0.889" "1.107" "1.042" "0.881" "0.998" "0.853" "0.979" "2.772" "429.1" "445.1" "381.5" "475.2" "447.0" "378.3" "428.2" "365.9" "420.3" "1189.4" "" "" "" "" "" "" "" "" "" "" "387.4" "343.3" "295.1" "320.0" "372.9" "322.9" "363.2" "264.8" "283.5" "1189.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437948072660631583" "False" "High" "IsMasterProtein" "O60664" "Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3" "0.000" "False" "64.103" "30" "11" "17" "11" "434" "47.0" "5.44" "57.36" "11" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf03036" "10226" "ENSG00000105355" "PLIN3" "A8K4Y9; hsa:10226; K7EQF4; O60664; Q53G77; Q9BS03; Q9UBD7; Q9UP92" "Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy" "" "6" "0" "0.988" "0.888" "0.985" "0.958" "0.828" "1.001" "1.085" "0.903" "0.667" "863.3" "853.1" "766.4" "850.6" "827.1" "714.9" "864.1" "936.7" "779.5" "576.0" "" "" "" "" "" "" "" "" "" "" "779.3" "658.0" "592.7" "572.8" "690.0" "610.2" "733.0" "677.9" "525.8" "576.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2236879561052220613" "False" "High" "IsMasterProtein" "Q9NX02" "NACHT, LRR and PYD domains-containing protein 2 OS=Homo sapiens OX=9606 GN=NLRP2 PE=1 SV=1" "0.000" "False" "63.963" "14" "14" "18" "14" "1062" "120.4" "6.07" "56.32" "14" "stress response;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf02758, Pf05729, Pf13516, Pf17776, Pf17779" "55655" "ENSG00000022556; ENSG00000273992; ENSG00000274638; ENSG00000275082; ENSG00000275399; ENSG00000275796; ENSG00000275843; ENSG00000278682; ENSG00000278789" "NLRP2" "B4DZL7; hsa:55655; I3L0G4; Q53FL5; Q59G09; Q8IXT0; Q9BVN5; Q9H6G6; Q9HAV9; Q9NWK3; Q9NX02" "" "Nucleotide-binding oligomerization domain (NOD) pathway" "1" "0" "1.009" "0.864" "1.050" "0.949" "0.857" "1.037" "0.794" "0.936" "3.511" "651.7" "657.8" "562.7" "684.0" "618.6" "558.5" "675.7" "517.4" "610.2" "2288.0" "" "" "" "" "" "" "" "" "" "" "588.3" "507.4" "435.2" "460.6" "516.0" "476.7" "573.2" "374.4" "411.6" "2288.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3761626498643372027" "False" "High" "IsMasterProtein" "P05362" "Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2" "0.000" "False" "63.762" "17" "8" "12" "8" "532" "57.8" "7.99" "46.03" "8" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf03921, Pf13895, Pf21146" "3383" "ENSG00000090339" "ICAM1" "B2R6M3; hsa:3383; P05362; Q5NKV7; Q96B50" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling; miRNA role in immune response in sepsis; Platelet-mediated interactions with vascular and circulating cells; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Urotensin-II-mediated signaling pathway; Role of ROS in COVID-19 endothelial dysfunction; IL-26 signaling pathways; Type II interferon signaling" "27" "0" "1.035" "0.944" "1.114" "0.977" "0.937" "0.992" "0.988" "1.026" "0.643" "495.9" "513.5" "468.3" "552.5" "484.5" "464.7" "491.8" "490.0" "508.6" "319.1" "" "" "" "" "" "" "" "" "" "" "447.7" "396.1" "362.2" "372.0" "404.1" "396.6" "417.2" "354.6" "343.0" "319.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4801012359298608333" "False" "High" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "0.000" "False" "63.637" "24" "12" "21" "12" "609" "67.3" "6.57" "59.76" "12" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372, Pf21171" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "OAS antiviral response" "Phosphodiesterases in neuronal function" "2" "0" "0.990" "0.858" "0.939" "0.967" "0.851" "0.984" "0.997" "0.882" "0.796" "778.1" "770.5" "667.5" "730.3" "752.6" "662.2" "765.8" "775.4" "686.6" "619.4" "" "" "" "" "" "" "" "" "" "" "702.3" "594.3" "516.2" "491.8" "627.8" "565.2" "649.6" "561.1" "463.1" "619.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7657012177295081485" "False" "High" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "0.000" "False" "63.634" "29" "9" "29" "9" "328" "37.1" "6.84" "90.67" "9" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "12" "0" "0.975" "0.971" "0.945" "0.988" "1.006" "0.914" "0.947" "0.973" "0.696" "2295.8" "2237.9" "2229.2" "2169.8" "2269.0" "2310.0" "2098.4" "2174.3" "2234.9" "1598.0" "" "" "" "" "" "" "" "" "" "" "2072.3" "1726.2" "1724.2" "1461.1" "1892.7" "1971.6" "1780.0" "1573.6" "1507.4" "1598.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670005547915153643" "False" "High" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "0.000" "False" "63.477" "35" "7" "14" "7" "261" "29.8" "5.55" "58.49" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "0.999" "1.452" "1.058" "1.000" "1.454" "0.964" "1.036" "1.465" "0.806" "758.0" "757.0" "1100.2" "802.0" "757.7" "1102.0" "730.8" "785.5" "1110.6" "610.9" "" "" "" "" "" "" "" "" "" "" "684.2" "583.9" "850.9" "540.0" "632.0" "940.6" "619.9" "568.5" "749.1" "610.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133937274084103067" "False" "High" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "0.000" "False" "63.390" "31" "8" "18" "8" "263" "28.5" "6.92" "53.86" "8" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Asymmetric localization of PCP proteins; Degradation of DVL; ER-Phagosome pathway; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.994" "1.091" "0.892" "1.131" "1.221" "1.010" "1.023" "1.197" "0.778" "641.0" "636.9" "699.1" "571.5" "724.8" "782.6" "647.6" "655.6" "767.3" "498.5" "" "" "" "" "" "" "" "" "" "" "578.6" "491.2" "540.7" "384.8" "604.6" "668.0" "549.3" "474.4" "517.5" "498.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8256721828910616389" "False" "High" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "0.000" "False" "63.389" "9" "15" "21" "15" "1824" "206.7" "6.47" "63.08" "15" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "3" "0" "0.907" "0.966" "0.940" "0.921" "0.960" "0.915" "0.969" "0.981" "1.140" "1667.2" "1512.5" "1609.9" "1567.8" "1536.0" "1601.1" "1525.9" "1616.1" "1634.9" "1900.7" "" "" "" "" "" "" "" "" "" "" "1504.9" "1166.7" "1245.1" "1055.7" "1281.3" "1366.5" "1294.4" "1169.5" "1102.7" "1900.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990547013884615551" "False" "High" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "0.000" "False" "63.381" "15" "12" "13" "12" "913" "101.3" "5.45" "49.03" "12" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "" "Ectoderm differentiation" "1" "0" "1.044" "0.837" "0.942" "1.023" "0.880" "1.018" "1.078" "0.897" "0.673" "806.5" "842.1" "675.3" "759.9" "824.8" "710.1" "821.1" "869.1" "723.1" "542.9" "" "" "" "" "" "" "" "" "" "" "728.0" "649.5" "522.3" "511.7" "688.0" "606.0" "696.5" "628.9" "487.7" "542.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7662049170687489427" "False" "High" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "0.000" "False" "63.357" "38" "14" "28" "14" "341" "39.8" "6.89" "83.75" "14" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "6" "0" "1.054" "1.052" "0.984" "0.968" "1.111" "1.008" "1.010" "1.076" "0.746" "1699.9" "1792.1" "1787.6" "1673.4" "1644.8" "1888.6" "1713.6" "1716.6" "1828.4" "1268.2" "" "" "" "" "" "" "" "" "" "" "1534.5" "1382.3" "1382.6" "1126.8" "1372.0" "1612.0" "1453.6" "1242.3" "1233.2" "1268.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813032805198607075" "False" "High" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "0.000" "False" "63.312" "21" "9" "20" "3" "429" "49.4" "6.81" "62.08" "9" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "" "22q11.2 copy number variation syndrome" "1" "0" "0.946" "1.074" "1.072" "0.866" "1.036" "0.974" "0.970" "1.017" "0.736" "677.3" "640.4" "727.5" "725.8" "586.6" "701.8" "659.5" "656.9" "688.9" "498.4" "" "" "" "" "" "" "" "" "" "" "611.3" "494.0" "562.6" "488.7" "489.3" "599.0" "559.5" "475.4" "464.7" "498.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415542887713691593" "False" "High" "IsMasterProtein" "Q01469" "Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3" "0.000" "False" "63.299" "53" "6" "38" "6" "135" "15.2" "7.01" "134.40" "6" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00061" "2171" "ENSG00000164687" "FABP5" "B2R4K0; hsa:2171; Q01469" "Neutrophil degranulation; Triglyceride catabolism; Signaling by Retinoic Acid" "PPAR signaling pathway; Fatty acid transporters" "5" "0" "1.046" "1.044" "1.078" "1.040" "1.104" "1.061" "1.051" "1.073" "0.690" "2714.1" "2838.5" "2833.5" "2926.8" "2823.6" "2997.2" "2878.6" "2851.5" "2911.6" "1873.4" "" "" "" "" "" "" "" "" "" "" "2450.0" "2189.4" "2191.5" "1970.9" "2355.4" "2558.2" "2441.8" "2063.6" "1963.8" "1873.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8364348392468163032" "False" "High" "IsMasterProtein" "P04040" "Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3" "0.000" "False" "62.981" "21" "10" "13" "10" "527" "59.7" "7.39" "46.42" "10" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00199, Pf06628" "847" "ENSG00000121691" "CAT" "A8K6C0; B2RCZ9; D3DR07; hsa:847; P04040; Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85" "Neutrophil degranulation; Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; Arsenic metabolism and reactive oxygen species generation; DNA damage response (only ATM dependent)" "12" "0" "1.021" "1.015" "1.092" "1.013" "1.040" "1.026" "0.925" "1.051" "0.830" "612.6" "625.2" "621.5" "669.1" "620.6" "637.3" "628.2" "566.7" "644.1" "508.6" "" "" "" "" "" "" "" "" "" "" "553.0" "482.3" "480.7" "450.6" "517.6" "543.9" "532.9" "410.1" "434.5" "508.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2351772574129659372" "False" "High" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "0.000" "False" "62.960" "19" "8" "14" "8" "517" "58.2" "7.49" "56.55" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "" "32" "0" "1.041" "0.971" "1.066" "1.047" "0.928" "0.985" "0.942" "1.047" "0.787" "1158.0" "1204.9" "1124.0" "1234.1" "1212.0" "1074.7" "1140.2" "1090.6" "1212.2" "911.0" "" "" "" "" "" "" "" "" "" "" "1045.3" "929.4" "869.3" "831.1" "1011.0" "917.3" "967.2" "789.3" "817.6" "911.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3292354779633865334" "False" "High" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "0.000" "False" "62.785" "7" "17" "20" "17" "2376" "266.8" "7.11" "60.18" "17" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "Ciliary landscape" "4" "0" "0.995" "0.886" "0.965" "1.017" "0.880" "1.025" "0.898" "0.875" "1.584" "863.2" "859.0" "764.9" "833.0" "878.2" "759.3" "884.7" "774.8" "755.3" "1366.9" "" "" "" "" "" "" "" "" "" "" "779.2" "662.6" "591.6" "560.9" "732.6" "648.1" "750.5" "560.7" "509.4" "1366.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7075703887839209806" "False" "High" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "0.000" "False" "62.783" "15" "14" "22" "14" "972" "112.2" "6.64" "67.81" "14" "" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "0.990" "1.007" "0.890" "0.982" "1.040" "0.943" "1.031" "0.958" "0.758" "1496.2" "1481.9" "1506.4" "1331.6" "1468.9" "1555.7" "1410.7" "1542.5" "1432.6" "1133.4" "" "" "" "" "" "" "" "" "" "" "1350.6" "1143.1" "1165.1" "896.7" "1225.3" "1327.8" "1196.7" "1116.3" "966.3" "1133.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1824011876683044668" "False" "High" "IsMasterProtein" "Q9ULA0" "Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2" "0.000" "False" "62.768" "19" "8" "14" "8" "485" "53.4" "7.58" "50.21" "8" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02127" "23549" "ENSG00000123992" "DNPEP" "hsa:23549; Q9BW44; Q9NUV5; Q9NV55; Q9ULA0" "" "Ciliary landscape" "1" "0" "0.990" "0.934" "0.950" "1.005" "1.041" "1.017" "1.080" "0.944" "0.605" "771.6" "763.9" "720.9" "733.0" "775.5" "802.9" "784.8" "833.7" "728.6" "466.7" "" "" "" "" "" "" "" "" "" "" "696.5" "589.2" "557.5" "493.6" "646.9" "685.3" "665.7" "603.3" "491.4" "466.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386790215885090291" "False" "High" "IsMasterProtein" "Q8N3X1" "Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3" "0.000" "False" "62.725" "10" "8" "15" "8" "1017" "110.2" "4.74" "55.11" "8" "" "nucleus" "" "Pf00397" "23360" "ENSG00000109920; ENSG00000285182" "FNBP4" "hsa:23360; Q8N3X1; Q9H985; Q9NT81; Q9Y2L7" "" "" "0" "0" "1.028" "1.007" "1.092" "1.051" "0.977" "1.025" "1.019" "0.989" "0.538" "1110.8" "1141.4" "1118.0" "1212.8" "1167.2" "1085.7" "1138.6" "1132.4" "1099.1" "597.3" "" "" "" "" "" "" "" "" "" "" "1002.7" "880.4" "864.7" "816.7" "973.7" "926.7" "965.9" "819.5" "741.3" "597.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4780754661784181438" "False" "High" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "0.000" "False" "62.555" "10" "10" "18" "10" "1038" "119.4" "4.82" "56.79" "10" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "0" "0.926" "1.026" "0.887" "0.837" "0.950" "0.860" "0.866" "0.923" "1.363" "891.4" "825.4" "914.3" "791.0" "745.8" "846.7" "766.9" "772.0" "822.4" "1215.0" "" "" "" "" "" "" "" "" "" "" "804.6" "636.7" "707.2" "532.6" "622.1" "722.7" "650.5" "558.7" "554.7" "1215.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5513100547130879649" "False" "High" "IsMasterProtein" "P13797" "Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4" "0.000" "False" "62.432" "10" "6" "60" "1" "630" "70.8" "5.60" "175.08" "6" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf13499" "5358" "ENSG00000102024" "PLS3" "A8K579; B1AQ09; B4DGB4; B7Z6M1; hsa:5358; P13797; Q86YI6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4181332469245940194" "False" "High" "IsMasterProtein" "Q9UMR2" "ATP-dependent RNA helicase DDX19B OS=Homo sapiens OX=9606 GN=DDX19B PE=1 SV=1" "0.000" "False" "62.382" "17" "9" "19" "9" "479" "53.9" "6.30" "66.27" "9" "other metabolic processes;transport" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11269" "ENSG00000157349" "DDX19B" "B3KNE9; B4DXS6; E7EMK4; hsa:11269; Q6FIB7; Q6IAE0; Q96KE7; Q9H0U0; Q9UMR2" "" "" "0" "0" "1.003" "0.818" "1.013" "1.059" "0.817" "1.048" "1.038" "0.820" "1.218" "1224.7" "1229.0" "1001.4" "1240.3" "1296.4" "1001.2" "1283.1" "1270.8" "1004.2" "1492.1" "" "" "" "" "" "" "" "" "" "" "1105.5" "948.0" "774.5" "835.2" "1081.4" "854.5" "1088.4" "919.7" "677.3" "1492.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7968684939462891772" "False" "High" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "0.000" "False" "62.336" "15" "15" "19" "15" "1030" "115.2" "5.40" "63.53" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "8" "0" "1.032" "1.201" "0.985" "1.047" "1.219" "1.012" "1.055" "1.195" "1.378" "1496.2" "1544.3" "1796.3" "1474.3" "1566.2" "1824.1" "1514.0" "1578.2" "1787.6" "2061.8" "" "" "" "" "" "" "" "" "" "" "1350.5" "1191.2" "1389.3" "992.8" "1306.5" "1556.9" "1284.3" "1142.1" "1205.7" "2061.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1817111684576735415" "False" "High" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "0.000" "False" "62.226" "45" "7" "26" "7" "151" "16.3" "5.67" "102.66" "7" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "8" "0" "0.927" "0.939" "0.977" "0.917" "0.938" "0.897" "0.983" "0.929" "0.761" "1382.1" "1281.9" "1297.4" "1350.2" "1267.7" "1296.7" "1240.4" "1358.9" "1283.3" "1052.4" "" "" "" "" "" "" "" "" "" "" "1247.6" "988.8" "1003.4" "909.3" "1057.4" "1106.8" "1052.2" "983.4" "865.6" "1052.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "575665869234459474" "False" "High" "IsMasterProtein" "P42331" "Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2" "0.000" "False" "62.203" "20" "14" "18" "14" "645" "73.4" "6.37" "57.55" "14" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane" "enzyme regulator activity" "Pf00169, Pf00620" "9938" "ENSG00000163219" "ARHGAP25" "A8K2Y1; B7Z498; E9PFQ7; G5E9G2; hsa:9938; P42331; Q8IXQ2" "RAC1 GTPase cycle" "" "1" "0" "0.948" "1.971" "1.137" "0.934" "1.900" "0.972" "0.685" "1.921" "5.936" "727.5" "689.5" "1433.8" "827.2" "679.7" "1382.4" "706.8" "498.4" "1397.8" "4318.8" "" "" "" "" "" "" "" "" "" "" "656.7" "531.9" "1109.0" "557.0" "567.0" "1179.9" "599.6" "360.7" "942.8" "4318.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8788439396421035672" "False" "High" "IsMasterProtein" "Q92621" "Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3" "0.000" "False" "62.190" "6" "13" "15" "13" "2012" "227.8" "6.19" "47.33" "13" "cell organization and biogenesis;transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf11894" "23165" "ENSG00000155561" "NUP205" "A6H8X3; hsa:23165; Q86YC1; Q92621" "SUMOylation of DNA replication proteins; HCMV Early Events; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "29" "0" "1.049" "0.787" "0.967" "1.072" "0.830" "1.029" "1.022" "0.863" "1.400" "491.6" "515.9" "387.0" "475.3" "527.2" "407.9" "506.1" "502.7" "424.3" "688.3" "" "" "" "" "" "" "" "" "" "" "443.8" "397.9" "299.3" "320.0" "439.8" "348.2" "429.4" "363.8" "286.2" "688.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6590851508053806454" "False" "High" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "0.000" "False" "62.133" "14" "11" "16" "11" "826" "92.2" "7.90" "57.31" "11" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "" "4" "0" "1.011" "1.046" "1.021" "1.016" "1.109" "0.983" "0.953" "1.091" "0.853" "1472.7" "1488.4" "1540.9" "1503.5" "1496.5" "1633.6" "1447.6" "1403.3" "1607.2" "1256.5" "" "" "" "" "" "" "" "" "" "" "1329.4" "1148.1" "1191.8" "1012.5" "1248.3" "1394.3" "1228.0" "1015.6" "1084.1" "1256.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583580330514197896" "False" "High" "IsMasterProtein" "P55809" "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1" "0.000" "False" "62.041" "25" "10" "19" "10" "520" "56.1" "7.46" "59.36" "10" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01144" "5019" "ENSG00000083720" "OXCT1" "B2R5V2; B7Z528; hsa:5019; P55809" "Mitochondrial protein degradation; Utilization of Ketone Bodies" "" "2" "0" "0.911" "1.091" "1.072" "1.037" "1.020" "1.071" "0.943" "0.985" "0.781" "837.6" "763.4" "913.6" "898.3" "868.9" "854.3" "897.4" "789.7" "824.8" "654.0" "" "" "" "" "" "" "" "" "" "" "756.1" "588.9" "706.6" "604.9" "724.8" "729.1" "761.3" "571.5" "556.3" "654.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3114131480513419355" "False" "High" "IsMasterProtein" "P62701" "Small ribosomal subunit protein eS4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "0.000" "False" "61.862" "37" "9" "26" "7" "263" "29.6" "10.15" "79.88" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "2" "0.980" "0.973" "0.955" "0.997" "0.980" "0.980" "0.991" "0.953" "0.566" "1966.2" "1927.6" "1913.7" "1878.2" "1960.0" "1927.4" "1927.4" "1948.1" "1873.1" "1112.9" "" "" "" "" "" "" "" "" "" "" "1774.8" "1486.8" "1480.1" "1264.8" "1634.9" "1645.1" "1634.9" "1409.8" "1263.4" "1112.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2660523182149503333" "False" "High" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "0.000" "False" "61.652" "32" "6" "17" "6" "219" "24.3" "4.94" "62.89" "6" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "Phosphate bond hydrolysis by NUDT proteins" "" "1" "0" "0.907" "1.022" "0.907" "0.913" "1.070" "0.885" "0.951" "1.036" "0.598" "1408.0" "1277.7" "1439.5" "1276.9" "1284.9" "1506.8" "1246.2" "1339.2" "1459.0" "842.1" "" "" "" "" "" "" "" "" "" "" "1271.0" "985.6" "1113.3" "859.9" "1071.8" "1286.1" "1057.2" "969.1" "984.1" "842.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4113768837461094803" "False" "High" "IsMasterProtein" "A0AVT1" "Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1" "0.000" "False" "61.510" "12" "12" "16" "12" "1052" "117.9" "6.14" "54.63" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "55236" "ENSG00000033178" "UBA6" "A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "0.929" "0.887" "0.983" "0.929" "0.876" "0.980" "0.803" "0.918" "2.271" "1060.1" "984.9" "940.0" "1042.6" "984.5" "928.3" "1039.2" "851.7" "973.6" "2407.9" "" "" "" "" "" "" "" "" "" "" "956.9" "759.7" "727.0" "702.1" "821.2" "792.3" "881.6" "616.4" "656.7" "2407.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3104846382151978420" "False" "High" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "0.000" "False" "61.490" "37" "9" "20" "9" "258" "27.3" "6.40" "66.16" "9" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "1.073" "1.144" "0.980" "1.021" "1.091" "1.013" "1.166" "1.085" "0.644" "1852.2" "1987.1" "2118.3" "1814.6" "1890.9" "2020.2" "1876.2" "2159.8" "2009.8" "1192.5" "" "" "" "" "" "" "" "" "" "" "1671.9" "1532.8" "1638.4" "1221.9" "1577.3" "1724.3" "1591.5" "1563.0" "1355.6" "1192.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7322766248926009386" "False" "High" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "0.000" "False" "61.397" "20" "8" "13" "8" "534" "60.2" "5.40" "43.87" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Neddylation" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "4" "0" "0.980" "0.959" "0.981" "1.040" "1.049" "0.892" "1.007" "1.036" "0.937" "517.6" "507.2" "496.2" "507.8" "538.4" "543.1" "461.8" "521.1" "536.3" "484.8" "" "" "" "" "" "" "" "" "" "" "467.2" "391.2" "383.8" "342.0" "449.1" "463.6" "391.7" "377.1" "361.7" "484.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1231047339708811007" "False" "High" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "0.000" "False" "61.273" "13" "16" "19" "16" "1094" "121.2" "6.04" "55.18" "16" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "" "2" "0" "0.955" "0.851" "0.963" "0.957" "0.796" "0.971" "0.949" "0.809" "1.187" "1526.2" "1457.4" "1299.0" "1470.0" "1460.5" "1215.0" "1482.5" "1449.0" "1235.2" "1812.2" "" "" "" "" "" "" "" "" "" "" "1377.7" "1124.2" "1004.7" "989.9" "1218.3" "1037.0" "1257.6" "1048.6" "833.2" "1812.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8833094404749326966" "False" "High" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "0.000" "False" "61.244" "20" "8" "18" "8" "508" "57.5" "7.80" "54.34" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "Cytosolic tRNA aminoacylation" "" "1" "0" "0.965" "0.774" "0.880" "0.925" "0.829" "0.890" "0.886" "0.790" "1.441" "652.6" "630.0" "505.4" "574.3" "603.4" "541.2" "580.7" "578.3" "515.3" "940.5" "" "" "" "" "" "" "" "" "" "" "589.1" "485.9" "390.9" "386.8" "503.3" "461.9" "492.6" "418.5" "347.5" "940.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-877235499680530927" "False" "High" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "0.000" "False" "61.091" "27" "8" "22" "3" "365" "38.6" "6.79" "72.24" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "7" "0" "1.073" "0.951" "1.283" "1.109" "0.965" "0.993" "0.906" "1.019" "1.702" "475.5" "510.3" "452.2" "610.1" "527.4" "459.1" "472.1" "430.7" "484.6" "809.5" "" "" "" "" "" "" "" "" "" "" "429.2" "393.6" "349.8" "410.9" "439.9" "391.8" "400.5" "311.7" "326.9" "809.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2550625188107110862" "False" "High" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "0.000" "False" "61.063" "40" "12" "17" "12" "325" "36.6" "6.79" "48.94" "12" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Glutathione conjugation; Formation of xylulose-5-phosphate" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "4" "0" "1.035" "0.882" "0.937" "1.016" "0.938" "1.013" "1.032" "0.915" "0.782" "887.3" "918.1" "782.4" "831.5" "901.2" "832.1" "898.8" "915.4" "811.6" "694.1" "" "" "" "" "" "" "" "" "" "" "800.9" "708.2" "605.1" "560.0" "751.8" "710.2" "762.5" "662.5" "547.4" "694.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2662746858814386989" "False" "High" "IsMasterProtein" "Q15024" "Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3" "0.000" "False" "60.997" "27" "7" "16" "7" "291" "31.8" "5.19" "60.49" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "23016" "ENSG00000075914" "EXOSC7" "hsa:23016; Q15024; Q96E72" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.025" "0.950" "1.026" "1.033" "1.006" "0.994" "0.989" "1.031" "0.551" "855.7" "877.2" "813.2" "877.6" "884.0" "860.5" "850.6" "846.5" "882.0" "471.5" "" "" "" "" "" "" "" "" "" "" "772.4" "676.6" "629.0" "591.0" "737.4" "734.4" "721.6" "612.6" "594.9" "471.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "626595147841982495" "False" "High" "IsMasterProtein" "Q92835" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2" "0.000" "False" "60.983" "11" "11" "13" "10" "1189" "133.2" "7.59" "43.92" "11" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00017" "3635" "ENSG00000168918; ENSG00000281614" "INPP5D" "hsa:3635; O00145; Q13544; Q13545; Q6P5A4; Q92656; Q92835; Q9UE80" "Downstream TCR signaling; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Synthesis of IP3 and IP4 in the cytosol; PECAM1 interactions" "B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway; Netrin-UNC5B signaling pathway; 5q35 copy number variation" "13" "1" "1.023" "0.918" "1.064" "0.984" "1.001" "0.975" "0.825" "0.979" "4.351" "638.8" "653.3" "586.4" "679.6" "628.9" "639.2" "623.1" "527.3" "625.3" "2779.5" "" "" "" "" "" "" "" "" "" "" "576.6" "503.9" "453.6" "457.6" "524.6" "545.5" "528.5" "381.6" "421.7" "2779.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174171264893505362" "False" "High" "IsMasterProtein" "Q9H2J4" "Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1" "0.000" "False" "60.970" "42" "8" "16" "8" "239" "27.6" "4.84" "53.84" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02114" "79031" "ENSG00000115539" "PDCL3" "B2RA00; hsa:79031; Q53S68; Q9H2J4" "" "" "0" "0" "0.990" "0.863" "1.001" "1.001" "0.964" "0.995" "1.000" "0.927" "0.735" "641.6" "635.3" "554.0" "642.3" "642.2" "618.4" "638.3" "641.9" "594.6" "471.9" "" "" "" "" "" "" "" "" "" "" "579.2" "490.0" "428.5" "432.5" "535.7" "527.8" "541.5" "464.5" "401.1" "471.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705238959085991770" "False" "High" "IsMasterProtein" "P08865" "Small ribosomal subunit protein uS2 OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "0.000" "False" "60.965" "34" "8" "30" "8" "295" "32.8" "4.87" "91.07" "8" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.937" "1.051" "0.932" "0.973" "1.110" "0.926" "0.962" "1.075" "0.632" "1493.9" "1399.7" "1570.3" "1391.9" "1453.1" "1657.6" "1383.7" "1437.8" "1605.8" "943.4" "" "" "" "" "" "" "" "" "" "" "1348.5" "1079.7" "1214.5" "937.3" "1212.1" "1414.8" "1173.8" "1040.5" "1083.1" "943.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888826320597161834" "False" "High" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "0.000" "False" "60.875" "20" "9" "19" "9" "551" "59.2" "7.15" "52.73" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "2" "0" "1.025" "0.914" "0.979" "1.036" "0.917" "0.998" "0.967" "0.838" "0.789" "1012.7" "1037.9" "925.7" "991.1" "1049.4" "928.8" "1010.7" "979.3" "848.4" "799.3" "" "" "" "" "" "" "" "" "" "" "914.1" "800.6" "716.0" "667.4" "875.3" "792.7" "857.3" "708.7" "572.3" "799.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531814392904203237" "False" "High" "IsMasterProtein" "P09884" "DNA polymerase alpha catalytic subunit OS=Homo sapiens OX=9606 GN=POLA1 PE=1 SV=2" "0.000" "False" "60.742" "13" "15" "19" "15" "1462" "165.8" "5.85" "51.83" "15" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08996, Pf12254" "5422" "ENSG00000101868" "POLA1" "hsa:5422; P09884; Q86UQ7" "Activation of the pre-replicative complex; Defective pyroptosis; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication" "13" "0" "0.878" "0.881" "0.901" "0.948" "0.894" "0.871" "0.835" "0.914" "2.627" "640.1" "561.9" "564.2" "577.0" "607.2" "572.6" "557.5" "534.5" "584.9" "1681.8" "" "" "" "" "" "" "" "" "" "" "577.8" "433.4" "436.3" "388.5" "506.5" "488.7" "473.0" "386.8" "394.5" "1681.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8496601930648358283" "False" "High" "IsMasterProtein" "Q5T6F2" "Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1" "0.000" "False" "60.709" "10" "9" "16" "9" "1119" "117.0" "7.34" "56.13" "9" "other biological processes" "nucleus;other cell component" "" "Pf12478" "55833" "ENSG00000137073" "UBAP2" "hsa:55833; Q2M2R4; Q5JV03; Q5T6F2; Q6PK34; Q8NC94; Q9P237" "" "" "0" "0" "0.937" "0.914" "0.888" "0.977" "0.922" "0.951" "1.047" "0.931" "0.713" "1327.0" "1242.9" "1213.3" "1178.6" "1296.1" "1222.9" "1262.3" "1388.7" "1235.3" "946.0" "" "" "" "" "" "" "" "" "" "" "1197.8" "958.7" "938.4" "793.7" "1081.1" "1043.8" "1070.8" "1005.0" "833.2" "946.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2468696703933973892" "False" "High" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "0.000" "False" "60.705" "18" "14" "16" "14" "792" "90.0" "7.15" "50.02" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Interconversion of nucleotide di- and triphosphates" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "4" "0" "0.966" "0.935" "1.018" "0.960" "0.896" "0.978" "1.026" "0.918" "0.744" "852.5" "823.8" "796.7" "868.1" "818.4" "764.1" "833.5" "874.3" "782.6" "633.9" "" "" "" "" "" "" "" "" "" "" "769.5" "635.5" "616.2" "584.6" "682.7" "652.2" "707.0" "632.7" "527.8" "633.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-504997331308259812" "False" "High" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "0.000" "False" "60.605" "22" "9" "16" "9" "413" "46.2" "7.01" "56.61" "9" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "11" "0" "0.931" "1.004" "0.930" "0.938" "1.031" "0.998" "0.911" "0.992" "0.744" "937.8" "873.4" "941.1" "871.7" "879.4" "966.7" "935.6" "854.2" "930.0" "697.7" "" "" "" "" "" "" "" "" "" "" "846.5" "673.7" "727.8" "587.0" "733.6" "825.1" "793.6" "618.2" "627.3" "697.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6467566476375476721" "False" "High" "IsMasterProtein" "Q03154" "Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1" "0.000" "False" "60.449" "25" "10" "22" "10" "408" "45.9" "6.18" "68.23" "10" "other metabolic processes" "non-structural extracellular;cytosol" "other molecular function" "Pf01546, Pf07687" "95" "ENSG00000243989" "ACY1" "C9J6I6; C9J9D8; C9JWD4; hsa:95; Q03154" "Aflatoxin activation and detoxification; Paracetamol ADME; Defective ACY1 causes encephalopathy" "Thyroxine (thyroid hormone) production" "4" "0" "1.007" "1.081" "1.017" "0.982" "1.181" "1.013" "1.005" "1.137" "0.814" "1139.6" "1148.1" "1231.7" "1159.5" "1119.2" "1346.1" "1154.3" "1145.4" "1295.4" "928.2" "" "" "" "" "" "" "" "" "" "" "1028.7" "885.6" "952.6" "780.8" "933.6" "1148.9" "979.2" "829.0" "873.7" "928.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154777414140805672" "False" "High" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "0.000" "False" "60.240" "17" "12" "33" "12" "708" "76.5" "5.07" "92.19" "12" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "" "2" "0" "0.998" "1.077" "1.005" "0.970" "1.041" "1.077" "1.138" "1.082" "0.748" "1457.4" "1453.8" "1569.9" "1465.0" "1413.0" "1517.3" "1570.1" "1658.0" "1576.4" "1090.1" "" "" "" "" "" "" "" "" "" "" "1315.5" "1121.4" "1214.2" "986.5" "1178.7" "1295.0" "1331.8" "1199.9" "1063.3" "1090.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588526575422441763" "False" "High" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "0.000" "False" "60.103" "16" "18" "23" "18" "1042" "117.7" "6.52" "68.64" "18" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf21408" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "0.980" "0.865" "0.974" "0.966" "0.804" "0.986" "0.958" "0.893" "0.683" "1309.1" "1282.9" "1132.7" "1274.7" "1264.6" "1052.6" "1290.8" "1253.6" "1169.3" "894.2" "" "" "" "" "" "" "" "" "" "" "1181.7" "989.6" "876.0" "858.4" "1054.9" "898.4" "1094.9" "907.2" "788.7" "894.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985233522455606046" "False" "High" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "0.000" "False" "60.065" "43" "9" "27" "9" "197" "22.6" "7.11" "78.17" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "0.945" "0.967" "0.974" "0.938" "1.011" "0.972" "1.066" "0.928" "0.684" "2008.3" "1898.3" "1942.7" "1956.6" "1883.8" "2030.9" "1951.8" "2141.3" "1863.0" "1372.8" "" "" "" "" "" "" "" "" "" "" "1812.9" "1464.3" "1502.5" "1317.6" "1571.4" "1733.4" "1655.7" "1549.7" "1256.5" "1372.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6941898924238947203" "False" "High" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "0.000" "False" "60.032" "27" "6" "38" "6" "204" "23.2" "5.11" "117.60" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "Ciliary landscape; Nephrotic syndrome; Vasopressin-regulated water reabsorption" "12" "0" "0.986" "1.069" "1.006" "0.994" "1.107" "1.011" "1.059" "1.094" "0.812" "2631.2" "2594.5" "2813.8" "2645.7" "2614.4" "2913.9" "2659.3" "2786.9" "2879.6" "2136.1" "" "" "" "" "" "" "" "" "" "" "2375.1" "2001.3" "2176.3" "1781.6" "2180.9" "2487.0" "2255.8" "2016.9" "1942.2" "2136.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3504989653461023373" "False" "High" "IsMasterProtein" "P51570" "Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1" "0.000" "False" "59.998" "29" "10" "18" "10" "392" "42.2" "6.46" "66.80" "10" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2584" "ENSG00000108479" "GALK1" "B2RC07; B4E1G6; hsa:2584; P51570" "Galactose catabolism; Defective GALK1 causes GALCT2" "Disorders of galactose metabolism" "3" "0" "1.027" "0.761" "1.048" "1.080" "0.807" "1.085" "1.049" "0.831" "0.716" "749.0" "769.5" "569.7" "784.9" "809.2" "604.3" "813.0" "786.1" "622.3" "536.0" "" "" "" "" "" "" "" "" "" "" "676.1" "593.5" "440.6" "528.5" "675.0" "515.8" "689.6" "568.9" "419.8" "536.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8716615983158352243" "False" "High" "IsMasterProtein" "P27695" "DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "0.000" "False" "59.898" "27" "7" "29" "7" "318" "35.5" "8.12" "102.84" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823; ENSG00000291796" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "10" "0" "1.018" "1.014" "0.965" "0.982" "0.988" "0.965" "0.924" "1.044" "1.282" "1437.4" "1462.7" "1457.5" "1386.8" "1411.1" "1420.0" "1387.7" "1328.3" "1500.2" "1843.2" "" "" "" "" "" "" "" "" "" "" "1297.5" "1128.2" "1127.3" "933.8" "1177.1" "1212.0" "1177.2" "961.2" "1011.8" "1843.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2832146552711634492" "False" "High" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "0.000" "False" "59.888" "16" "15" "18" "9" "1023" "115.9" "6.86" "54.57" "15" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "9" "5" "1.012" "0.851" "1.022" "1.021" "0.818" "1.008" "0.989" "0.847" "0.747" "1374.8" "1391.7" "1170.6" "1404.5" "1404.2" "1124.3" "1386.2" "1359.3" "1163.8" "1027.3" "" "" "" "" "" "" "" "" "" "" "1241.0" "1073.5" "905.4" "945.8" "1171.3" "959.6" "1175.8" "983.7" "785.0" "1027.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184092773991491015" "False" "High" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "0.000" "False" "59.830" "32" "10" "16" "10" "380" "42.6" "8.62" "51.71" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "Base excision repair; DNA repair pathways, full network" "8" "0" "1.037" "1.043" "0.886" "0.972" "0.987" "0.946" "0.851" "0.951" "1.837" "1125.0" "1166.3" "1173.5" "997.2" "1093.1" "1110.6" "1064.4" "957.1" "1069.6" "2066.2" "" "" "" "" "" "" "" "" "" "" "1015.5" "899.7" "907.7" "671.5" "911.8" "947.9" "902.9" "692.6" "721.4" "2066.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2954674220390740852" "False" "High" "IsMasterProtein" "P41218" "Myeloid cell nuclear differentiation antigen OS=Homo sapiens OX=9606 GN=MNDA PE=1 SV=1" "0.000" "False" "59.692" "20" "8" "11" "8" "407" "45.8" "9.76" "42.49" "8" "stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf02758, Pf02760" "4332" "ENSG00000163563" "MNDA" "P41218" "Neutrophil degranulation" "" "1" "0" "1.022" "1.308" "0.971" "1.092" "1.388" "1.079" "0.909" "1.291" "1.917" "383.8" "392.3" "501.9" "372.6" "419.3" "532.6" "414.0" "348.9" "495.6" "735.9" "" "" "" "" "" "" "" "" "" "" "346.4" "302.6" "388.1" "250.9" "349.7" "454.6" "351.2" "252.5" "334.3" "735.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6919500497101416540" "False" "High" "IsMasterProtein" "Q9UJU6" "Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1" "0.000" "False" "59.659" "21" "7" "15" "7" "430" "48.2" "5.05" "55.07" "7" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241, Pf14604" "28988" "ENSG00000136279" "DBNL" "A4D2I9; B4DDP6; B4DEM2; C9J7P1; hsa:28988; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; Q9UJU6" "Neutrophil degranulation; Neurexins and neuroligins; Caspase-mediated cleavage of cytoskeletal proteins" "T-cell receptor signaling pathway" "4" "0" "0.923" "0.988" "1.036" "0.947" "0.947" "0.991" "0.986" "0.969" "1.731" "604.0" "557.2" "596.7" "625.9" "572.1" "572.1" "598.7" "595.5" "585.1" "1045.2" "" "" "" "" "" "" "" "" "" "" "545.2" "429.8" "461.5" "421.5" "477.2" "488.3" "507.9" "431.0" "394.6" "1045.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135854214922228039" "False" "High" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "0.000" "False" "59.442" "25" "12" "16" "12" "585" "64.9" "8.87" "47.76" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "3" "0" "0.998" "0.978" "0.940" "0.964" "1.068" "0.957" "0.993" "1.000" "0.914" "521.8" "520.6" "510.2" "490.3" "503.3" "557.1" "499.5" "518.2" "521.8" "477.2" "" "" "" "" "" "" "" "" "" "" "471.1" "401.6" "394.6" "330.2" "419.8" "475.5" "423.7" "375.0" "351.9" "477.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701772359172858038" "False" "High" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "0.000" "False" "59.441" "9" "12" "14" "12" "1475" "153.8" "8.73" "45.89" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; SUMOylation of DNA replication proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "TGF-beta signaling pathway" "29" "0" "1.049" "1.074" "0.969" "1.132" "1.107" "1.023" "1.100" "0.977" "1.035" "466.9" "489.5" "501.4" "452.5" "528.3" "516.6" "477.4" "513.5" "455.9" "483.4" "" "" "" "" "" "" "" "" "" "" "421.4" "377.6" "387.8" "304.7" "440.7" "440.9" "405.0" "371.6" "307.5" "483.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4388967430464997560" "False" "High" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "0.000" "False" "59.388" "30" "11" "19" "10" "410" "46.6" "7.37" "58.93" "11" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Separation of Sister Chromatids; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "18" "1" "0.981" "0.939" "0.982" "0.999" "1.044" "0.990" "0.987" "0.980" "0.833" "1025.3" "1006.1" "962.3" "1006.7" "1024.1" "1070.5" "1015.2" "1012.1" "1004.5" "854.1" "" "" "" "" "" "" "" "" "" "" "925.5" "776.1" "744.2" "677.9" "854.3" "913.6" "861.2" "732.5" "677.5" "854.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934522081491213014" "False" "High" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "0.000" "False" "59.376" "37" "10" "16" "5" "318" "34.7" "6.61" "55.12" "10" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "5-Phosphoribose 1-diphosphate biosynthesis" "" "1" "0" "0.946" "0.856" "0.930" "0.903" "0.872" "0.901" "0.918" "0.821" "0.689" "1178.3" "1114.7" "1008.8" "1095.9" "1064.6" "1027.0" "1061.1" "1081.9" "967.9" "811.5" "" "" "" "" "" "" "" "" "" "" "1063.7" "859.8" "780.2" "738.0" "888.0" "876.5" "900.2" "782.9" "652.8" "811.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-564768690041684779" "False" "High" "IsMasterProtein" "Q9H0L4" "Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1" "0.000" "False" "59.334" "23" "11" "17" "5" "616" "64.4" "7.25" "50.98" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "23283" "ENSG00000177613" "CSTF2T" "B2RAR9; hsa:23283; O75174; Q53HK6; Q7LGE8; Q8N6T1; Q9H0L4" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "1.058" "0.858" "1.027" "1.084" "0.871" "1.054" "1.095" "0.880" "0.826" "189.3" "200.4" "162.4" "194.4" "205.2" "164.8" "199.5" "207.3" "166.7" "156.4" "" "" "" "" "" "" "" "" "" "" "170.9" "154.6" "125.6" "130.9" "171.2" "140.7" "169.2" "150.0" "112.4" "156.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939378456610215612" "False" "High" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "0.000" "False" "59.241" "10" "12" "19" "9" "1239" "142.0" "7.46" "53.73" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "Oxidative Stress Induced Senescence" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "7" "3" "1.072" "0.801" "1.016" "1.009" "0.809" "1.013" "0.921" "0.873" "1.016" "726.8" "779.3" "582.0" "738.7" "733.5" "588.3" "736.4" "669.7" "634.3" "738.6" "" "" "" "" "" "" "" "" "" "" "656.0" "601.1" "450.1" "497.5" "611.9" "502.1" "624.7" "484.6" "427.8" "738.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1449875230825116072" "False" "High" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "0.000" "False" "58.971" "18" "12" "15" "11" "620" "69.9" "5.59" "52.65" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "6" "1" "1.061" "2.506" "1.053" "1.063" "2.637" "1.051" "0.990" "2.317" "1.205" "570.0" "604.5" "1428.2" "600.2" "605.8" "1503.0" "599.0" "564.4" "1320.4" "686.9" "" "" "" "" "" "" "" "" "" "" "514.5" "466.3" "1104.6" "404.1" "505.3" "1282.9" "508.1" "408.4" "890.6" "686.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4007751392279359432" "False" "High" "IsMasterProtein" "Q562R1" "Beta-actin-like protein 2 OS=Homo sapiens OX=9606 GN=ACTBL2 PE=1 SV=2" "0.000" "False" "58.808" "15" "6" "95" "1" "376" "42.0" "5.59" "282.42" "6" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "345651" "ENSG00000169067" "ACTBL2" "B2RPJ1; hsa:345651; Q562R1; Q562R2; Q562S9; Q562X8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1718244645714628913" "False" "High" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "0.000" "False" "58.795" "14" "14" "21" "14" "1087" "123.8" "6.32" "57.69" "14" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "1.021" "0.944" "1.064" "1.003" "0.924" "0.963" "1.027" "1.031" "0.830" "737.8" "753.6" "696.3" "785.4" "740.3" "682.1" "710.5" "757.8" "760.9" "612.2" "" "" "" "" "" "" "" "" "" "" "666.0" "581.3" "538.6" "528.9" "617.6" "582.2" "602.7" "548.4" "513.2" "612.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1880293335037512275" "False" "High" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "0.000" "False" "58.777" "2" "4" "22" "4" "2078" "205.3" "9.58" "79.05" "4" "other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "0" "1.021" "1.053" "1.055" "1.118" "1.064" "1.141" "1.048" "1.090" "0.802" "1204.1" "1229.5" "1268.2" "1270.8" "1346.2" "1281.2" "1373.6" "1261.8" "1313.1" "965.4" "" "" "" "" "" "" "" "" "" "" "1086.9" "948.4" "980.8" "855.7" "1122.9" "1093.5" "1165.2" "913.2" "885.7" "965.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92352165089450524" "False" "High" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "0.000" "False" "58.747" "20" "10" "16" "10" "546" "59.2" "4.36" "48.86" "10" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "" "VEGFA-VEGFR2 signaling; mRNA processing" "2" "0" "0.907" "1.504" "0.909" "0.836" "1.548" "0.831" "0.586" "1.524" "4.763" "391.8" "355.5" "589.3" "356.2" "327.7" "606.5" "325.7" "229.7" "597.1" "1866.3" "" "" "" "" "" "" "" "" "" "" "353.7" "274.2" "455.8" "239.9" "273.3" "517.6" "276.3" "166.2" "402.8" "1866.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8097806180956091720" "False" "High" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "0.000" "False" "58.738" "22" "9" "22" "4" "425" "47.8" "5.05" "71.98" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Transcriptional Regulation by E2F6; HDACs deacetylate histones; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in progeria" "20" "4" "0.947" "1.153" "0.974" "0.961" "1.135" "1.022" "1.042" "1.043" "0.936" "1484.7" "1406.0" "1711.4" "1445.9" "1427.6" "1684.9" "1518.1" "1546.8" "1548.0" "1389.1" "" "" "" "" "" "" "" "" "" "" "1340.2" "1084.5" "1323.7" "973.7" "1190.8" "1438.1" "1287.7" "1119.4" "1044.1" "1389.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257366520332167042" "False" "High" "IsMasterProtein" "Q13422" "DNA-binding protein Ikaros OS=Homo sapiens OX=9606 GN=IKZF1 PE=1 SV=1" "0.000" "False" "58.505" "21" "9" "16" "7" "519" "57.5" "6.58" "59.22" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10320" "ENSG00000185811" "IKZF1" "A4D260; B4E0Z1; D3DVM5; hsa:10320; O00598; Q13422; Q53XL2; Q69BM4; Q8WVA3" "" "Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets" "2" "1" "1.071" "0.797" "1.021" "1.122" "0.832" "1.002" "1.065" "0.886" "1.420" "708.1" "758.2" "564.0" "723.0" "794.8" "589.2" "709.4" "754.3" "627.7" "1005.5" "" "" "" "" "" "" "" "" "" "" "639.2" "584.8" "436.2" "486.9" "663.0" "502.9" "601.7" "545.9" "423.4" "1005.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6937145884149963662" "False" "High" "IsMasterProtein" "Q15306" "Interferon regulatory factor 4 OS=Homo sapiens OX=9606 GN=IRF4 PE=1 SV=1" "0.000" "False" "58.380" "22" "9" "13" "9" "451" "51.7" "6.86" "49.06" "9" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3662" "ENSG00000137265" "IRF4" "hsa:3662; Q15306; Q5VUI7; Q99660" "Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling; Interferon alpha/beta signaling; Nuclear events stimulated by ALK signaling in cancer" "B cell receptor signaling pathway; Apoptosis; Vitamin D receptor pathway; Pre-implantation embryo; Development of pulmonary dendritic cells and macrophage subsets; Prion disease pathway; White fat cell differentiation; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Type II interferon signaling; T-cell receptor signaling pathway" "15" "0" "0.987" "0.824" "1.067" "1.000" "0.837" "1.042" "0.946" "0.844" "1.914" "812.9" "802.0" "670.0" "867.1" "812.6" "680.5" "847.0" "769.1" "686.3" "1555.6" "" "" "" "" "" "" "" "" "" "" "733.8" "618.6" "518.2" "583.9" "677.8" "580.8" "718.5" "556.6" "462.9" "1555.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1477701677307109055" "False" "High" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "0.000" "False" "58.290" "25" "13" "19" "13" "616" "68.1" "7.21" "57.13" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "Fanconi Anemia Pathway; SUMOylation of DNA damage response and repair proteins; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "38" "0" "1.103" "1.325" "0.995" "1.121" "1.223" "1.032" "1.072" "1.286" "1.555" "1528.5" "1685.3" "2025.2" "1520.5" "1713.7" "1869.8" "1578.0" "1637.9" "1966.3" "2376.1" "" "" "" "" "" "" "" "" "" "" "1379.7" "1299.9" "1566.4" "1023.9" "1429.5" "1595.9" "1338.6" "1185.3" "1326.2" "2376.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5396921561883894054" "False" "High" "IsMasterProtein" "Q96GD0" "Chronophin OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2" "0.000" "False" "58.252" "36" "9" "14" "9" "296" "31.7" "6.55" "49.68" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13242, Pf13344" "57026" "ENSG00000241360" "PDXP" "hsa:57026; Q96GD0; Q9UGY2" "" "" "0" "0" "1.015" "1.024" "1.070" "1.057" "1.059" "1.039" "0.947" "1.134" "0.802" "576.8" "585.7" "590.7" "617.3" "609.7" "610.8" "599.1" "546.3" "654.0" "462.5" "" "" "" "" "" "" "" "" "" "" "520.7" "451.8" "456.9" "415.7" "508.6" "521.3" "508.2" "395.4" "441.1" "462.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3099345167640791747" "False" "High" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "0.000" "False" "58.145" "22" "8" "22" "8" "357" "38.3" "7.97" "69.39" "8" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "Disorders of fructose metabolism; Polyol pathway" "4" "0" "0.981" "0.977" "1.143" "0.996" "1.022" "0.949" "0.985" "1.090" "0.845" "1209.8" "1186.5" "1181.7" "1383.3" "1205.5" "1236.0" "1147.6" "1191.8" "1319.2" "1022.3" "" "" "" "" "" "" "" "" "" "" "1092.1" "915.2" "914.0" "931.5" "1005.6" "1054.9" "973.5" "862.5" "889.8" "1022.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211102690049465357" "False" "High" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "0.000" "False" "58.048" "22" "9" "18" "9" "421" "46.6" "8.37" "58.85" "9" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "13" "0" "0.996" "0.886" "0.923" "1.040" "0.908" "1.029" "1.014" "0.966" "0.593" "689.8" "687.0" "611.4" "636.9" "717.5" "626.2" "710.0" "699.3" "666.1" "408.8" "" "" "" "" "" "" "" "" "" "" "622.7" "529.9" "472.8" "428.9" "598.5" "534.5" "602.3" "506.1" "449.3" "408.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8984223167418137130" "False" "High" "IsMasterProtein" "P62633" "CCHC-type zinc finger nucleic acid binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "0.000" "False" "57.989" "45" "7" "29" "7" "177" "19.5" "7.71" "98.48" "7" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "0" "1.005" "1.063" "0.961" "1.048" "1.102" "0.990" "1.228" "1.092" "0.767" "1394.5" "1401.5" "1482.2" "1340.2" "1461.1" "1536.3" "1381.0" "1712.8" "1523.4" "1069.7" "" "" "" "" "" "" "" "" "" "" "1258.7" "1081.0" "1146.4" "902.5" "1218.8" "1311.2" "1171.5" "1239.6" "1027.5" "1069.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4858909322532710110" "False" "High" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "0.000" "False" "57.942" "16" "10" "27" "10" "649" "70.9" "7.39" "76.05" "10" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "Detoxification of Reactive Oxygen Species; PPARA activates gene expression; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "16" "0" "1.003" "1.155" "1.029" "1.008" "1.169" "1.023" "1.045" "1.218" "0.771" "1811.0" "1817.0" "2091.7" "1863.6" "1826.0" "2117.0" "1853.2" "1891.6" "2205.7" "1396.1" "" "" "" "" "" "" "" "" "" "" "1634.8" "1401.5" "1617.8" "1254.9" "1523.2" "1806.8" "1572.1" "1369.0" "1487.7" "1396.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314773965349869651" "False" "High" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "0.000" "False" "57.926" "44" "7" "12" "7" "204" "22.6" "9.45" "48.22" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "" "TAR syndrome" "1" "0" "1.071" "1.142" "1.044" "1.025" "1.105" "1.034" "1.172" "1.138" "0.725" "464.4" "497.4" "530.3" "484.6" "476.1" "512.9" "480.2" "544.4" "528.3" "336.9" "" "" "" "" "" "" "" "" "" "" "419.2" "383.6" "410.1" "326.4" "397.1" "437.8" "407.4" "394.0" "356.3" "336.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5190108194104216904" "False" "High" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "0.000" "False" "57.901" "24" "12" "20" "12" "452" "51.3" "8.32" "66.61" "12" "transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "Mitochondrial protein import" "" "1" "0" "1.025" "0.965" "1.007" "1.056" "0.894" "0.983" "1.078" "0.888" "0.979" "1198.8" "1229.0" "1157.2" "1207.7" "1266.0" "1072.1" "1178.7" "1291.8" "1064.3" "1173.5" "" "" "" "" "" "" "" "" "" "" "1082.2" "948.0" "895.0" "813.3" "1056.0" "915.1" "999.9" "934.8" "717.9" "1173.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892989875718200247" "False" "High" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "0.000" "False" "57.897" "29" "7" "37" "7" "239" "27.4" "5.73" "114.47" "7" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Ub-specific processing proteases; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Somitogenesis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Regulation of RUNX3 expression and activity" "Proteasome degradation" "61" "0" "0.957" "0.991" "0.891" "0.916" "1.028" "0.904" "0.954" "0.953" "0.649" "2715.0" "2597.1" "2690.6" "2419.2" "2485.7" "2790.1" "2454.1" "2590.8" "2588.3" "1761.1" "" "" "" "" "" "" "" "" "" "" "2450.8" "2003.2" "2081.0" "1629.1" "2073.5" "2381.4" "2081.8" "1874.9" "1745.8" "1761.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7309351128836490355" "False" "High" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "0.000" "False" "57.893" "34" "5" "13" "5" "209" "24.0" "7.81" "42.88" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Apoptosis induced DNA fragmentation" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "4" "0" "1.124" "1.241" "0.874" "0.949" "1.216" "1.063" "1.143" "0.947" "0.841" "817.1" "918.3" "1014.4" "714.3" "775.4" "994.0" "868.4" "934.2" "773.6" "687.5" "" "" "" "" "" "" "" "" "" "" "737.6" "708.3" "784.6" "481.0" "646.8" "848.4" "736.7" "676.1" "521.8" "687.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "906200433272310872" "False" "High" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "0.000" "False" "57.748" "30" "11" "21" "11" "432" "47.6" "5.97" "68.01" "11" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "VEGFA-VEGFR2 signaling" "4" "0" "1.010" "1.010" "0.995" "1.035" "1.038" "1.031" "1.080" "1.064" "0.743" "1778.9" "1796.5" "1796.7" "1770.8" "1840.4" "1846.1" "1834.8" "1920.5" "1892.1" "1321.8" "" "" "" "" "" "" "" "" "" "" "1605.8" "1385.7" "1389.6" "1192.5" "1535.2" "1575.7" "1556.5" "1389.8" "1276.2" "1321.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7061207721996529093" "False" "High" "IsMasterProtein" "P08758" "Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2" "0.000" "False" "57.670" "35" "12" "32" "11" "320" "35.9" "5.05" "90.76" "12" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "308" "ENSG00000164111" "ANXA5" "D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9" "Platelet degranulation" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation" "4" "1" "0.903" "0.922" "1.013" "0.930" "0.904" "1.013" "0.909" "0.941" "1.925" "2253.4" "2035.6" "2077.9" "2282.6" "2095.8" "2036.3" "2282.7" "2048.1" "2120.6" "4338.0" "" "" "" "" "" "" "" "" "" "" "2034.1" "1570.2" "1607.1" "1537.1" "1748.2" "1738.0" "1936.4" "1482.2" "1430.3" "4338.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "556799029181218119" "False" "High" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "0.000" "False" "57.505" "19" "10" "15" "8" "522" "59.0" "5.15" "46.86" "10" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "0" "0.999" "0.812" "0.935" "0.906" "0.815" "0.943" "0.858" "0.824" "1.405" "908.6" "908.0" "738.2" "849.2" "823.0" "740.3" "856.7" "779.4" "748.4" "1276.3" "" "" "" "" "" "" "" "" "" "" "820.2" "700.4" "571.0" "571.8" "686.5" "631.9" "726.8" "564.0" "504.8" "1276.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4173136633731686100" "False" "High" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "0.000" "False" "57.453" "14" "12" "14" "12" "882" "97.5" "6.21" "44.71" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "Interferon gamma signaling; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; p53 transcriptional gene network; Acute myeloid leukemia; DNA damage response" "13" "0" "1.023" "0.974" "1.092" "1.013" "0.991" "0.980" "0.896" "1.013" "1.652" "751.7" "768.7" "732.3" "821.1" "761.7" "745.1" "736.7" "673.5" "761.4" "1241.9" "" "" "" "" "" "" "" "" "" "" "678.6" "592.9" "566.4" "552.9" "635.4" "636.0" "625.0" "487.4" "513.5" "1241.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5905184492137342602" "False" "High" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "0.000" "False" "57.326" "27" "13" "20" "13" "390" "43.3" "8.06" "64.95" "13" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "17" "0" "0.952" "0.767" "0.937" "0.921" "0.776" "0.904" "0.926" "0.772" "0.766" "1140.6" "1086.4" "875.0" "1068.7" "1050.7" "884.8" "1030.6" "1056.5" "880.3" "873.9" "" "" "" "" "" "" "" "" "" "" "1029.6" "838.0" "676.7" "719.6" "876.5" "755.2" "874.2" "764.6" "593.7" "873.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6816817128509432528" "False" "High" "IsMasterProtein" "P10155" "RNA-binding protein RO60 OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "0.000" "False" "57.311" "25" "14" "22" "14" "538" "60.6" "8.03" "73.22" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "1.061" "1.044" "1.028" "1.032" "1.065" "1.025" "1.019" "1.103" "0.800" "1173.7" "1244.8" "1225.9" "1206.5" "1210.8" "1250.0" "1203.2" "1196.4" "1294.9" "938.7" "" "" "" "" "" "" "" "" "" "" "1059.5" "960.2" "948.1" "812.4" "1010.0" "1066.9" "1020.7" "865.8" "873.4" "938.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2160825122742080574" "False" "High" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "0.000" "False" "57.225" "34" "9" "29" "7" "271" "30.5" "6.29" "97.66" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Neutrophil degranulation" "Selenium micronutrient network" "2" "2" "0.996" "0.973" "1.062" "1.058" "1.086" "1.000" "1.043" "1.083" "0.704" "1339.8" "1334.6" "1303.7" "1422.3" "1416.9" "1455.6" "1339.2" "1397.4" "1450.5" "943.1" "" "" "" "" "" "" "" "" "" "" "1209.4" "1029.4" "1008.4" "957.8" "1181.9" "1242.4" "1136.0" "1011.3" "978.4" "943.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469021931412063719" "False" "High" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "0.000" "False" "57.099" "15" "14" "30" "14" "953" "107.1" "6.05" "84.22" "14" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Neutrophil degranulation" "" "3" "0" "0.974" "0.892" "0.953" "0.975" "0.881" "0.982" "0.972" "0.931" "0.881" "1143.6" "1113.6" "1020.4" "1090.2" "1115.4" "1008.0" "1123.5" "1111.4" "1064.5" "1007.9" "" "" "" "" "" "" "" "" "" "" "1032.3" "858.9" "789.2" "734.2" "930.5" "860.4" "953.0" "804.3" "718.0" "1007.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7179197342339518209" "False" "High" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "0.000" "False" "57.089" "40" "7" "14" "6" "286" "32.9" "5.69" "53.34" "7" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "MHC class II antigen presentation; COPI-mediated anterograde transport; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "" "8" "1" "1.031" "1.205" "0.957" "0.962" "1.171" "1.019" "0.979" "1.230" "1.003" "698.6" "720.1" "842.0" "668.5" "672.2" "817.9" "712.1" "684.1" "859.3" "700.7" "" "" "" "" "" "" "" "" "" "" "630.6" "555.4" "651.3" "450.2" "560.7" "698.1" "604.1" "495.1" "579.6" "700.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3731678403857668842" "False" "High" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "0.000" "False" "56.900" "38" "8" "16" "8" "282" "31.4" "7.02" "59.73" "8" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Glutathione conjugation" "Phase I biotransformations, non-P450" "2" "0" "1.043" "1.069" "0.975" "1.047" "1.165" "1.068" "1.038" "1.085" "0.780" "905.2" "943.8" "967.4" "882.7" "947.8" "1054.3" "967.2" "939.2" "981.9" "706.5" "" "" "" "" "" "" "" "" "" "" "817.1" "728.0" "748.2" "594.4" "790.6" "899.9" "820.4" "679.7" "662.3" "706.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4997024104720897707" "False" "High" "IsMasterProtein" "Q9BZK7" "F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1" "0.000" "False" "56.873" "17" "7" "15" "7" "514" "55.6" "5.55" "52.18" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "79718" "ENSG00000177565" "TBL1XR1" "D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1" "Heme signaling; Transcriptional activation of mitochondrial biogenesis; HCMV Early Events; HDACs deacetylate histones; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity" "Rett syndrome" "20" "0" "0.968" "1.285" "0.999" "0.999" "1.199" "1.045" "0.991" "1.287" "1.009" "1166.2" "1129.2" "1498.4" "1165.2" "1165.5" "1398.7" "1218.3" "1155.1" "1500.7" "1176.4" "" "" "" "" "" "" "" "" "" "" "1052.7" "871.0" "1158.9" "784.6" "972.2" "1193.8" "1033.4" "835.9" "1012.2" "1176.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870726190365747871" "False" "High" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "0.000" "False" "56.797" "21" "7" "21" "7" "394" "44.7" "6.74" "67.64" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "8" "0" "1.007" "1.060" "1.008" "1.057" "1.138" "0.994" "0.975" "1.080" "0.823" "1308.8" "1318.4" "1387.1" "1319.8" "1383.8" "1489.4" "1301.4" "1276.5" "1413.3" "1077.1" "" "" "" "" "" "" "" "" "" "" "1181.4" "1016.9" "1072.8" "888.8" "1154.3" "1271.2" "1103.9" "923.8" "953.3" "1077.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533705047032389806" "False" "High" "IsMasterProtein" "P62241" "Small ribosomal subunit protein eS8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "0.000" "False" "56.773" "39" "7" "22" "7" "208" "24.2" "10.32" "61.64" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.930" "0.984" "0.922" "1.031" "0.990" "0.904" "0.971" "0.994" "0.611" "886.8" "824.3" "872.8" "818.0" "914.4" "877.6" "801.3" "860.9" "881.5" "542.1" "" "" "" "" "" "" "" "" "" "" "800.4" "635.9" "675.1" "550.8" "762.7" "749.1" "679.8" "623.0" "594.6" "542.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965270540937199853" "False" "High" "IsMasterProtein" "Q14151" "Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1" "0.000" "False" "56.773" "12" "11" "17" "4" "953" "107.4" "6.16" "56.28" "11" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "9667" "ENSG00000130254" "SAFB2" "B4DKG3; hsa:9667; Q14151; Q8TB13" "" "" "0" "0" "0.985" "0.931" "1.114" "1.236" "0.934" "1.078" "1.198" "1.208" "1.036" "74.4" "73.2" "69.3" "82.8" "91.9" "69.5" "80.2" "89.1" "89.9" "77.1" "" "" "" "" "" "" "" "" "" "" "67.2" "56.5" "53.6" "55.8" "76.7" "59.3" "68.0" "64.5" "60.6" "77.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1079834079423301401" "False" "High" "IsMasterProtein" "Q8TD19" "Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2" "0.000" "False" "56.704" "13" "11" "13" "11" "979" "107.1" "5.74" "48.69" "11" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00415, Pf13540" "91754" "ENSG00000119638" "NEK9" "hsa:91754; Q52LK6; Q8NCN0; Q8TCY4; Q8TD19; Q9UPI4; Q9Y6S4; Q9Y6S5; Q9Y6S6" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "Ciliopathies" "4" "0" "1.005" "0.904" "0.928" "0.955" "0.929" "0.943" "0.961" "0.995" "1.026" "486.2" "488.7" "439.6" "451.0" "464.2" "451.6" "458.5" "467.0" "483.9" "498.8" "" "" "" "" "" "" "" "" "" "" "438.9" "377.0" "340.0" "303.7" "387.2" "385.4" "389.0" "338.0" "326.4" "498.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048249212605468111" "False" "High" "IsMasterProtein" "P30876" "DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1" "0.000" "False" "56.445" "13" "15" "17" "15" "1174" "133.8" "6.87" "56.50" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "5431" "ENSG00000047315" "POLR2B" "A8K1A8; hsa:5431; P30876; Q8IZ61" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.010" "0.914" "1.006" "1.044" "0.949" "1.028" "0.970" "0.964" "1.212" "956.5" "966.3" "874.7" "962.1" "998.6" "908.2" "983.2" "927.7" "922.5" "1159.7" "" "" "" "" "" "" "" "" "" "" "863.4" "745.4" "676.5" "647.9" "833.0" "775.2" "834.0" "671.4" "622.2" "1159.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5118939103406682552" "False" "High" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "0.000" "False" "56.364" "13" "13" "15" "13" "1081" "118.6" "4.96" "49.52" "13" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "1.006" "0.925" "1.200" "0.945" "0.983" "0.940" "0.924" "0.923" "3.588" "213.6" "215.0" "197.6" "256.4" "202.0" "210.0" "200.8" "197.4" "197.1" "766.6" "" "" "" "" "" "" "" "" "" "" "192.8" "165.8" "152.8" "172.7" "168.5" "179.3" "170.3" "142.9" "133.0" "766.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2034922387344060046" "False" "High" "IsMasterProtein" "P12955" "Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3" "0.000" "False" "56.345" "23" "9" "11" "9" "493" "54.5" "6.00" "37.35" "9" "protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00557, Pf05195" "5184" "ENSG00000124299" "PEPD" "A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8; hsa:5184; P12955; Q8TBN9; Q9BT75" "" "" "0" "0" "0.976" "0.952" "1.039" "1.018" "1.003" "0.867" "0.969" "1.097" "0.713" "433.6" "423.2" "412.7" "450.5" "441.3" "435.0" "376.0" "420.0" "475.7" "309.0" "" "" "" "" "" "" "" "" "" "" "391.4" "326.5" "319.2" "303.4" "368.1" "371.2" "319.0" "304.0" "320.9" "309.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917642798524543660" "False" "High" "IsMasterProtein" "P52566" "Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3" "0.000" "False" "56.302" "37" "8" "43" "8" "201" "23.0" "5.21" "129.74" "8" "signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02115" "397" "ENSG00000111348" "ARHGDIB" "B5BU79; hsa:397; P52566" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOH GTPase cycle" "Fas ligand pathway and stress induction of heat shock proteins; Vasopressin-regulated water reabsorption; G13 signaling pathway" "9" "0" "0.931" "0.954" "0.923" "0.970" "0.941" "0.986" "0.968" "0.956" "0.866" "3109.1" "2894.0" "2964.6" "2870.5" "3014.9" "2925.3" "3065.1" "3009.6" "2973.6" "2691.1" "" "" "" "" "" "" "" "" "" "" "2806.5" "2232.3" "2292.9" "1933.0" "2514.9" "2496.8" "2600.1" "2178.0" "2005.7" "2691.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9199223731198630068" "False" "High" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "0.000" "False" "56.206" "43" "10" "22" "10" "227" "25.6" "9.16" "77.34" "10" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "Factors involved in megakaryocyte development and platelet production" "" "1" "0" "0.991" "0.998" "0.955" "0.950" "1.048" "0.963" "0.926" "1.059" "0.699" "1096.1" "1086.1" "1094.1" "1046.4" "1041.0" "1149.0" "1055.8" "1014.8" "1161.3" "766.5" "" "" "" "" "" "" "" "" "" "" "989.4" "837.8" "846.2" "704.6" "868.4" "980.7" "895.6" "734.4" "783.3" "766.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4686891910023409545" "False" "High" "IsMasterProtein" "P62140" "Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3" "0.000" "False" "55.974" "31" "9" "25" "2" "327" "37.2" "6.19" "75.19" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5500" "ENSG00000213639" "PPP1CB" "B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45" "Triglyceride catabolism; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; RHO GTPases activate CIT; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway" "19" "0" "1.085" "1.049" "1.210" "1.101" "1.086" "1.048" "1.002" "1.235" "1.006" "267.2" "290.0" "280.2" "323.2" "294.3" "290.1" "279.9" "267.6" "329.9" "268.7" "" "" "" "" "" "" "" "" "" "" "241.2" "223.7" "216.7" "217.7" "245.5" "247.6" "237.5" "193.7" "222.5" "268.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852807762900550805" "False" "High" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "0.000" "False" "55.955" "41" "7" "12" "7" "264" "29.2" "5.97" "45.81" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of expression of SLITs and ROBOs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.960" "1.078" "1.019" "1.045" "1.127" "0.953" "0.924" "1.154" "0.677" "612.1" "587.6" "660.2" "624.0" "639.5" "689.8" "583.5" "565.9" "706.5" "414.2" "" "" "" "" "" "" "" "" "" "" "552.5" "453.3" "510.6" "420.2" "533.5" "588.8" "495.0" "409.5" "476.5" "414.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6222929657638767461" "False" "High" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "0.000" "False" "55.900" "36" "9" "42" "8" "216" "23.7" "9.41" "115.28" "9" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "4" "1" "1.013" "0.986" "0.962" "0.965" "1.003" "0.962" "0.944" "1.022" "0.909" "2392.0" "2423.5" "2358.8" "2301.5" "2307.1" "2399.2" "2300.6" "2258.6" "2445.8" "2174.1" "" "" "" "" "" "" "" "" "" "" "2159.2" "1869.3" "1824.4" "1549.8" "1924.5" "2047.7" "1951.6" "1634.5" "1649.7" "2174.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3497794903438612376" "False" "High" "IsMasterProtein" "Q92541" "RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4" "0.000" "False" "55.898" "10" "7" "12" "7" "710" "80.3" "8.15" "40.98" "7" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity" "Pf03126" "23168" "ENSG00000137815" "RTF1" "hsa:23168; Q92541; Q96BX6" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "5" "0" "0.934" "0.801" "0.972" "0.979" "0.816" "0.961" "0.929" "0.841" "1.061" "678.7" "634.2" "543.9" "660.0" "664.7" "553.9" "652.1" "630.5" "570.8" "719.9" "" "" "" "" "" "" "" "" "" "" "612.6" "489.2" "420.7" "444.4" "554.5" "472.8" "553.1" "456.3" "385.0" "719.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222820814571899525" "False" "High" "IsMasterProtein" "Q9UJ70" "N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4" "0.000" "False" "55.861" "24" "7" "13" "7" "344" "37.4" "6.24" "45.64" "7" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01869" "55577" "ENSG00000124357" "NAGK" "B4DLZ5; hsa:55577; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37; Q9UJ70" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "1.136" "0.953" "1.047" "1.009" "1.071" "1.025" "1.044" "1.018" "0.741" "463.0" "526.1" "441.4" "484.7" "467.2" "495.8" "474.5" "483.2" "471.3" "343.1" "" "" "" "" "" "" "" "" "" "" "417.9" "405.8" "341.4" "326.4" "389.7" "423.2" "402.5" "349.7" "317.9" "343.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200179838073860903" "False" "High" "IsMasterProtein" "O76031" "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" "0.000" "False" "55.666" "22" "12" "15" "12" "633" "69.2" "7.58" "46.92" "12" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07724, Pf10431" "10845" "ENSG00000166855" "CLPX" "A1L428; A8K8F1; B9EGI8; hsa:10845; O76031; Q9H4D9" "Mitochondrial protein degradation" "" "1" "0" "0.952" "0.827" "0.825" "0.999" "0.775" "0.958" "0.978" "0.712" "1.006" "557.8" "531.3" "461.4" "460.0" "557.4" "432.1" "534.4" "545.8" "397.1" "561.4" "" "" "" "" "" "" "" "" "" "" "503.5" "409.8" "356.9" "309.8" "465.0" "368.8" "453.3" "395.0" "267.9" "561.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390977729729594241" "False" "High" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "0.000" "False" "55.574" "12" "12" "14" "12" "1019" "117.9" "6.61" "45.16" "12" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Ub-specific processing proteases; Peroxisomal protein import; Insulin receptor recycling" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "5" "0" "0.924" "1.175" "0.871" "0.926" "1.170" "0.912" "0.934" "1.106" "1.308" "814.3" "752.5" "956.6" "709.5" "754.1" "953.1" "742.7" "760.3" "901.1" "1064.9" "" "" "" "" "" "" "" "" "" "" "735.1" "580.5" "739.9" "477.8" "629.0" "813.5" "630.0" "550.2" "607.8" "1064.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1633285367868477603" "False" "High" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "0.000" "False" "55.483" "20" "14" "25" "7" "583" "68.5" "6.37" "77.59" "14" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "Regulation of actin cytoskeleton" "4" "0" "0.978" "1.088" "1.066" "0.987" "1.103" "0.988" "1.020" "1.319" "0.708" "239.1" "233.8" "260.1" "255.0" "236.0" "263.9" "236.2" "243.8" "315.4" "169.2" "" "" "" "" "" "" "" "" "" "" "215.8" "180.3" "201.2" "171.7" "196.8" "225.2" "200.4" "176.5" "212.8" "169.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6330757226080927514" "False" "High" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "0.000" "False" "55.443" "37" "9" "21" "2" "309" "35.6" "5.54" "63.82" "9" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; CTLA4 inhibitory signaling; DARPP-32 events; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "53" "8" "0.999" "0.927" "1.011" "0.974" "0.984" "1.036" "1.039" "1.038" "0.776" "721.3" "720.2" "668.9" "729.3" "702.4" "709.8" "747.3" "749.7" "748.8" "559.6" "" "" "" "" "" "" "" "" "" "" "651.1" "555.5" "517.3" "491.1" "585.9" "605.8" "633.9" "542.5" "505.0" "559.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5483705117675463598" "False" "High" "IsMasterProtein" "P10321" "HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3" "0.000" "False" "55.409" "20" "6" "19" "2" "366" "40.6" "6.04" "66.87" "6" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3107" "ENSG00000204525" "HLA-C" "hsa:3107; O02863; O02864; O02865; O02866; O02958; O19505; O19652; O19676; O62879; O62882; O62883; O62888; O78060; O78061; O78062; O78063; O78067; O78068; O78069; O78072; O78083; O78090; O78091; O78149; O78165; O78166; O78178; O78202; O78203; O78211; O78214; P04222; P10321; P30499; P30500; P30501; P30502; P30503; P30504; P30505; P30506; P30507; P30508; P30509; P30510; P79498; Q07000; Q29631; Q29641; Q29643; Q29652; Q29743; Q29768; Q29862; Q29864; Q29865; Q29867; Q29921; Q29959; Q29960; Q29963; Q29986; Q29989; Q29990; Q29991; Q29992; Q29993; Q30192; Q31605; Q31627; Q860R1; Q860R2; Q95463; Q95603; Q95604; Q99528; Q9BD28; Q9GIK4; Q9GIK8; Q9GJ33; Q9MY30; Q9MY31; Q9MY35; Q9MY49; Q9MY74; Q9MYI3; Q9TNN7; Q9TNZ8; Q9TPS4; Q9TPV8; Q9TPX2; Q9TQB4; Q9TQJ5; Q9TQP9; Q9UM32; Q9UM33; Q9UM42; Q9UQS9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 interactions; Neutrophil degranulation; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome" "13" "0" "1.102" "0.854" "1.190" "0.858" "0.666" "0.947" "1.055" "1.011" "0.443" "76.0" "83.7" "64.9" "90.4" "65.2" "50.6" "71.9" "80.2" "76.8" "33.7" "" "" "" "" "" "" "" "" "" "" "68.6" "64.6" "50.2" "60.9" "54.4" "43.2" "61.0" "58.0" "51.8" "33.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413684009215812555" "False" "High" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "0.000" "False" "55.374" "21" "7" "16" "7" "372" "40.9" "8.35" "61.22" "7" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "6" "0" "0.959" "1.008" "1.011" "0.949" "0.993" "0.986" "0.970" "0.958" "0.789" "1031.0" "989.0" "1039.5" "1042.3" "978.6" "1023.8" "1016.8" "1000.1" "987.5" "813.8" "" "" "" "" "" "" "" "" "" "" "930.6" "762.8" "804.0" "701.9" "816.3" "873.8" "862.6" "723.8" "666.1" "813.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2843591473366045892" "False" "High" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "0.000" "False" "55.346" "30" "9" "26" "2" "330" "37.5" "6.33" "79.62" "9" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins; DARPP-32 events" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system" "15" "7" "0.939" "0.999" "0.937" "0.975" "1.068" "0.936" "0.971" "1.007" "0.880" "1286.3" "1208.4" "1285.0" "1205.4" "1254.3" "1373.9" "1203.7" "1248.5" "1295.1" "1131.4" "" "" "" "" "" "" "" "" "" "" "1161.1" "932.1" "993.9" "811.7" "1046.3" "1172.7" "1021.0" "903.5" "873.5" "1131.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7727744455345483682" "False" "High" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "0.000" "False" "55.088" "27" "7" "18" "7" "293" "32.8" "7.50" "62.49" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985, Pf21266" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.020" "0.934" "1.030" "1.024" "0.912" "1.007" "1.016" "0.938" "0.471" "943.8" "962.9" "881.2" "972.5" "966.2" "860.8" "950.5" "959.2" "885.3" "444.3" "" "" "" "" "" "" "" "" "" "" "852.0" "742.8" "681.5" "654.9" "805.9" "734.7" "806.3" "694.2" "597.1" "444.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "692688187917917011" "False" "High" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "0.000" "False" "54.938" "35" "7" "14" "7" "210" "23.7" "6.42" "51.93" "7" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "0.969" "1.066" "1.031" "1.017" "1.037" "1.024" "1.199" "1.065" "0.599" "1031.0" "998.9" "1098.9" "1063.4" "1048.3" "1069.1" "1055.6" "1236.3" "1098.3" "617.5" "" "" "" "" "" "" "" "" "" "" "930.7" "770.5" "849.9" "716.1" "874.4" "912.5" "895.4" "894.7" "740.8" "617.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453678624484122586" "False" "High" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "0.000" "False" "54.913" "14" "12" "15" "12" "868" "96.0" "6.52" "41.97" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "5" "0" "0.952" "1.039" "1.039" "0.999" "1.037" "0.919" "0.432" "1.126" "8.843" "197.9" "188.4" "205.7" "205.7" "197.8" "205.2" "181.9" "85.5" "222.9" "1750.4" "" "" "" "" "" "" "" "" "" "" "178.7" "145.3" "159.1" "138.5" "165.0" "175.2" "154.3" "61.9" "150.4" "1750.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3450396974392384393" "False" "High" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "0.000" "False" "54.910" "18" "8" "14" "8" "559" "61.5" "7.50" "53.90" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "1.002" "1.163" "1.098" "1.106" "1.202" "1.080" "1.088" "1.226" "0.722" "590.6" "591.6" "686.7" "648.5" "653.3" "710.1" "637.5" "642.6" "724.2" "426.4" "" "" "" "" "" "" "" "" "" "" "533.1" "456.3" "531.1" "436.7" "545.0" "606.1" "540.8" "465.0" "488.5" "426.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1968544072233028588" "False" "High" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "0.000" "False" "54.847" "15" "10" "14" "9" "707" "76.1" "9.44" "45.58" "10" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "mRNA processing; Type 2 papillary renal cell carcinoma" "4" "1" "1.067" "1.214" "1.083" "1.110" "1.244" "1.004" "0.895" "1.175" "2.156" "813.6" "868.2" "988.0" "880.9" "903.2" "1011.9" "816.7" "727.8" "955.7" "1754.3" "" "" "" "" "" "" "" "" "" "" "734.4" "669.7" "764.2" "593.2" "753.4" "863.7" "692.8" "526.7" "644.6" "1754.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765155610572928931" "False" "High" "IsMasterProtein" "Q8IZ73" "Pseudouridylate synthase RPUSD2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2" "0.000" "False" "54.682" "23" "9" "12" "9" "545" "61.3" "7.17" "36.47" "9" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00849" "27079" "ENSG00000166133" "RPUSD2" "B4DDD1; hsa:27079; Q7L989; Q8IZ73; Q92939; Q96IA7; Q96N50" "" "" "0" "0" "1.086" "1.078" "0.996" "1.018" "1.119" "1.137" "0.991" "1.018" "0.803" "398.4" "432.6" "429.6" "396.9" "405.7" "445.6" "452.9" "394.7" "405.4" "319.7" "" "" "" "" "" "" "" "" "" "" "359.6" "333.7" "332.3" "267.3" "338.4" "380.3" "384.2" "285.6" "273.4" "319.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4462152622631022902" "False" "High" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "0.000" "False" "54.649" "12" "13" "15" "12" "1105" "122.8" "5.76" "46.77" "13" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "1" "0.907" "1.571" "1.070" "1.051" "1.161" "1.090" "0.478" "1.322" "9.562" "138.8" "125.9" "218.0" "148.6" "145.9" "161.1" "151.2" "66.3" "183.5" "1327.2" "" "" "" "" "" "" "" "" "" "" "125.3" "97.1" "168.6" "100.0" "121.7" "137.5" "128.3" "48.0" "123.8" "1327.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318153562653389017" "False" "High" "IsMasterProtein" "O43837" "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" "0.000" "False" "54.549" "29" "12" "22" "12" "385" "42.2" "8.46" "60.69" "12" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3420" "ENSG00000101365" "IDH3B" "B2RDR1; D3DVX2; D3DVX3; hsa:3420; O43837; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99" "Citric acid cycle (TCA cycle)" "TCA cycle (aka Krebs or citric acid cycle)" "2" "0" "1.029" "1.089" "0.982" "1.070" "1.064" "1.003" "1.052" "1.128" "0.681" "775.9" "798.4" "845.1" "762.2" "829.8" "825.8" "778.2" "815.8" "875.4" "528.4" "" "" "" "" "" "" "" "" "" "" "700.4" "615.8" "653.6" "513.3" "692.2" "704.9" "660.1" "590.4" "590.4" "528.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868363632382073498" "False" "High" "IsMasterProtein" "Q6UB35" "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" "0.000" "False" "54.402" "12" "12" "18" "11" "978" "105.7" "8.06" "51.58" "12" "other metabolic processes;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "25902" "ENSG00000120254" "MTHFD1L" "hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8" "Metabolism of folate and pterines" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "3" "0" "1.105" "0.731" "1.082" "1.052" "0.842" "0.966" "0.991" "0.809" "0.744" "412.1" "455.2" "301.2" "446.0" "433.4" "347.0" "398.1" "408.3" "333.5" "306.8" "" "" "" "" "" "" "" "" "" "" "372.0" "351.1" "233.0" "300.3" "361.5" "296.2" "337.7" "295.5" "225.0" "306.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004494409327660908" "False" "High" "IsMasterProtein" "P07205" "Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3" "0.000" "False" "54.246" "17" "7" "31" "2" "417" "44.8" "8.54" "101.21" "7" "other metabolic processes;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00162" "5232" "ENSG00000170950" "PGK2" "B2R6Y8; hsa:5232; P07205; Q9H107" "Glycolysis; Gluconeogenesis" "Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "6" "0" "0.965" "1.072" "0.767" "0.991" "1.055" "0.977" "1.018" "0.938" "0.673" "361.5" "348.9" "387.4" "277.3" "358.4" "381.4" "353.0" "367.8" "339.1" "243.3" "" "" "" "" "" "" "" "" "" "" "326.3" "269.1" "299.6" "186.8" "299.0" "325.5" "299.5" "266.2" "228.7" "243.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174842833444890787" "False" "High" "IsMasterProtein" "Q99613" "Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1" "0.000" "False" "54.235" "14" "13" "16" "13" "913" "105.3" "5.68" "54.04" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "8663" "ENSG00000184110" "EIF3C" "A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "1.051" "0.910" "1.056" "1.048" "0.940" "1.036" "0.766" "0.951" "4.262" "418.4" "439.8" "380.7" "442.0" "438.5" "393.4" "433.3" "320.4" "397.8" "1783.4" "" "" "" "" "" "" "" "" "" "" "377.7" "339.2" "294.5" "297.6" "365.7" "335.8" "367.5" "231.8" "268.3" "1783.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3306595998206250770" "False" "High" "IsMasterProtein" "P62753" "Small ribosomal subunit protein eS6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "0.000" "False" "54.122" "26" "7" "33" "7" "249" "28.7" "10.84" "99.48" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; rRNA modification in the nucleus and cytosol; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1 modulates host translation machinery" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "49" "0" "0.978" "0.987" "0.947" "1.016" "0.959" "0.964" "1.048" "0.931" "0.570" "1740.6" "1702.7" "1718.2" "1647.7" "1767.9" "1668.6" "1677.4" "1823.9" "1620.3" "991.4" "" "" "" "" "" "" "" "" "" "" "1571.2" "1313.4" "1328.9" "1109.6" "1474.7" "1424.2" "1422.9" "1319.9" "1092.9" "991.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4154359228263867930" "False" "High" "IsMasterProtein" "P46781" "Small ribosomal subunit protein uS4 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "0.000" "False" "54.048" "47" "11" "36" "11" "194" "22.6" "10.65" "104.62" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "0.986" "0.984" "0.968" "0.976" "0.954" "0.986" "0.986" "0.954" "0.583" "1758.5" "1733.8" "1730.0" "1702.9" "1715.7" "1677.8" "1733.2" "1734.0" "1677.6" "1025.7" "" "" "" "" "" "" "" "" "" "" "1587.4" "1337.3" "1338.0" "1146.7" "1431.1" "1432.1" "1470.3" "1254.9" "1131.5" "1025.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5539470002617871814" "False" "High" "IsMasterProtein" "Q9P2R7" "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" "0.000" "False" "54.019" "20" "9" "12" "9" "463" "50.3" "7.42" "41.89" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8803" "ENSG00000136143" "SUCLA2" "B2RDE7; hsa:8803; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; Q9P2R7" "Citric acid cycle (TCA cycle)" "" "1" "0" "1.062" "0.736" "0.998" "1.032" "0.800" "1.036" "1.008" "0.807" "1.068" "438.8" "466.1" "323.0" "437.9" "452.9" "351.1" "454.8" "442.1" "354.0" "468.5" "" "" "" "" "" "" "" "" "" "" "396.1" "359.5" "249.8" "294.9" "377.8" "299.7" "385.8" "319.9" "238.8" "468.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5278147799990617038" "False" "High" "IsMasterProtein" "P78318" "Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1" "0.000" "False" "53.962" "21" "6" "13" "6" "339" "39.2" "5.38" "41.64" "6" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf04177" "3476" "ENSG00000089289" "IGBP1" "P78318; Q8TAB2" "" "16p11.2 proximal deletion syndrome" "1" "0" "0.964" "0.882" "1.028" "0.923" "0.864" "1.028" "1.006" "0.818" "1.166" "696.7" "671.5" "614.7" "716.3" "643.1" "601.8" "715.9" "700.7" "569.9" "812.2" "" "" "" "" "" "" "" "" "" "" "628.9" "518.0" "475.4" "482.3" "536.5" "513.7" "607.3" "507.1" "384.4" "812.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5365621191326057651" "False" "High" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "0.000" "False" "53.949" "28" "6" "22" "6" "239" "26.5" "7.81" "69.84" "6" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "1.038" "1.049" "1.129" "1.051" "1.089" "1.066" "1.065" "1.104" "0.628" "1014.9" "1053.4" "1064.2" "1145.9" "1066.6" "1105.7" "1082.2" "1080.6" "1120.1" "637.0" "" "" "" "" "" "" "" "" "" "" "916.1" "812.6" "823.1" "771.7" "889.7" "943.7" "918.0" "782.0" "755.5" "637.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3980314117452886183" "False" "High" "IsMasterProtein" "P62979" "Ubiquitin-ribosomal protein eS31 fusion protein OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2" "0.000" "False" "53.937" "44" "6" "110" "6" "156" "18.0" "9.64" "332.52" "6" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01599" "6233" "ENSG00000143947" "RPS27A" "hsa:6233; P02248; P02249; P02250; P14798; P62979; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BQ77; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Stimuli-sensing channels; Negative regulation of MAPK pathway; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Orc1 removal from chromatin; Assembly of the pre-replicative complex; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Regulation of signaling by CBL; Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; ISG15 antiviral mechanism; Downregulation of ERBB4 signaling; Regulation of PTEN localization; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Circadian Clock; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Interferon alpha/beta signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through Homologous Recombination (HRR); Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "Cytoplasmic ribosomal proteins" "203" "0" "1.002" "1.130" "0.979" "0.955" "1.100" "0.975" "1.070" "1.083" "0.950" "6503.4" "6519.5" "7351.6" "6364.8" "6213.3" "7152.0" "6342.0" "6957.9" "7043.4" "6181.3" "" "" "" "" "" "" "" "" "" "" "5870.4" "5028.8" "5686.0" "4286.1" "5182.9" "6104.4" "5379.8" "5035.4" "4750.7" "6181.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7990537509462567326" "False" "High" "IsMasterProtein" "P16298" "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2" "0.000" "False" "53.925" "16" "8" "19" "3" "524" "59.0" "5.91" "60.03" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5532" "ENSG00000107758" "PPP3CB" "hsa:5532; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; ROBO receptors bind AKAP5" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "16" "0" "0.986" "0.666" "0.883" "0.903" "0.787" "1.038" "0.763" "0.760" "0.808" "79.6" "78.5" "53.1" "70.3" "71.9" "62.6" "82.7" "60.8" "60.5" "64.4" "" "" "" "" "" "" "" "" "" "" "71.9" "60.6" "41.0" "47.3" "60.0" "53.5" "70.1" "44.0" "40.8" "64.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604627173476332081" "False" "High" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "0.000" "False" "53.824" "17" "12" "14" "12" "798" "88.8" "6.25" "44.82" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "0.897" "0.877" "1.045" "0.964" "0.942" "0.943" "0.624" "1.015" "5.792" "513.0" "460.0" "449.9" "536.3" "494.8" "483.3" "484.0" "319.9" "520.9" "2971.5" "" "" "" "" "" "" "" "" "" "" "463.1" "354.8" "347.9" "361.1" "412.7" "412.5" "410.5" "231.5" "351.3" "2971.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8980263924004467581" "False" "High" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "0.000" "False" "53.771" "13" "14" "15" "14" "1107" "123.6" "7.03" "49.72" "14" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "27" "0" "0.987" "0.895" "0.992" "0.954" "0.860" "0.905" "1.016" "0.847" "1.402" "692.5" "683.8" "620.1" "686.9" "660.4" "595.8" "626.7" "703.3" "586.5" "971.0" "" "" "" "" "" "" "" "" "" "" "625.1" "527.4" "479.6" "462.6" "550.8" "508.5" "531.7" "509.0" "395.6" "971.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515792609303095651" "False" "High" "IsMasterProtein" "P61204" "ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2" "0.000" "False" "53.709" "42" "6" "24" "3" "181" "20.6" "7.43" "57.45" "6" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "377" "ENSG00000134287" "ARF3" "A8K6G8; B7ZB63; hsa:377; P16587; P61204" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane" "" "3" "2" "0.998" "1.018" "1.093" "1.031" "1.052" "0.941" "0.980" "1.029" "0.717" "784.6" "782.9" "798.5" "857.3" "808.6" "825.1" "738.2" "769.0" "807.7" "562.5" "" "" "" "" "" "" "" "" "" "" "708.3" "603.9" "617.6" "577.3" "674.5" "704.2" "626.2" "556.5" "544.8" "562.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7469427958651967746" "False" "High" "IsMasterProtein" "Q9GZL7" "Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2" "0.000" "False" "53.684" "27" "10" "15" "10" "423" "47.7" "5.90" "47.74" "10" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08154" "55759" "ENSG00000138442" "WDR12" "B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.985" "1.117" "1.065" "1.033" "1.118" "1.062" "1.012" "1.220" "0.898" "833.5" "821.3" "930.8" "887.4" "860.7" "931.9" "885.5" "843.8" "1016.7" "748.2" "" "" "" "" "" "" "" "" "" "" "752.4" "633.5" "719.9" "597.6" "718.0" "795.4" "751.2" "610.6" "685.7" "748.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2475503787040523239" "False" "High" "IsMasterProtein" "Q9UM54" "Unconventional myosin-VI OS=Homo sapiens OX=9606 GN=MYO6 PE=1 SV=4" "0.000" "False" "53.653" "10" "12" "14" "12" "1294" "149.6" "8.53" "43.49" "12" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf16521, Pf21521" "4646" "ENSG00000196586" "MYO6" "A6H8V4; E1P540; hsa:4646; Q5TEM5; Q5TEM6; Q5TEM7; Q9BZZ7; Q9UEG2; Q9UM54" "RHOU GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Trafficking of AMPA receptors; Gap junction degradation" "VEGFA-VEGFR2 signaling; Joubert syndrome" "7" "0" "1.102" "0.869" "1.000" "1.017" "0.878" "1.033" "0.999" "0.954" "0.920" "531.3" "585.5" "461.8" "531.4" "540.1" "466.7" "548.8" "530.8" "506.8" "488.5" "" "" "" "" "" "" "" "" "" "" "479.5" "451.6" "357.2" "357.9" "450.6" "398.3" "465.5" "384.2" "341.8" "488.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7312941423538826307" "False" "High" "IsMasterProtein" "P31350" "Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1" "0.000" "False" "53.606" "25" "9" "19" "7" "389" "44.8" "5.38" "62.99" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00268" "6241" "ENSG00000171848" "RRM2" "B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7" "Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway" "8" "1" "0.926" "0.986" "1.028" "0.910" "0.897" "0.941" "0.996" "0.932" "0.691" "970.3" "898.7" "956.7" "997.3" "883.4" "870.2" "912.7" "966.1" "904.2" "670.6" "" "" "" "" "" "" "" "" "" "" "875.9" "693.2" "740.0" "671.6" "736.9" "742.7" "774.2" "699.2" "609.9" "670.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8500687369034294287" "False" "High" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "0.000" "False" "53.510" "45" "9" "16" "2" "205" "22.7" "6.21" "51.48" "9" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "" "6" "5" "0.930" "1.127" "0.971" "0.984" "1.161" "0.988" "0.958" "1.108" "0.675" "857.5" "797.5" "966.4" "832.3" "843.6" "995.4" "847.3" "821.3" "950.4" "578.9" "" "" "" "" "" "" "" "" "" "" "774.0" "615.2" "747.4" "560.5" "703.7" "849.6" "718.7" "594.3" "641.0" "578.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454508349601298395" "False" "High" "IsMasterProtein" "Q99447" "Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1" "0.000" "False" "53.423" "27" "10" "15" "10" "389" "43.8" "6.92" "49.23" "10" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01467" "5833" "ENSG00000185813" "PCYT2" "B7Z7A5; B7ZAS0; F5H8B1; hsa:5833; Q6IBM3; Q96G08; Q99447" "Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "5" "0" "0.964" "0.935" "0.914" "0.970" "0.961" "0.874" "0.941" "0.966" "0.689" "1504.3" "1450.2" "1406.8" "1374.7" "1459.7" "1445.4" "1315.4" "1416.3" "1453.4" "1036.1" "" "" "" "" "" "" "" "" "" "" "1357.9" "1118.6" "1088.0" "925.7" "1217.7" "1233.6" "1115.8" "1024.9" "980.3" "1036.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400072782813286453" "False" "High" "IsMasterProtein" "P62424" "Large ribosomal subunit protein eL8 OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2" "0.000" "False" "53.277" "25" "6" "13" "6" "266" "30.0" "10.61" "44.30" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6130" "ENSG00000148303; ENSG00000280858" "RPL7A" "hsa:6130; P11518; P62424; Q5T8U4" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.949" "1.078" "1.025" "1.029" "1.011" "1.071" "1.054" "1.083" "0.348" "490.9" "465.8" "529.4" "503.2" "505.3" "496.3" "525.9" "517.5" "531.9" "170.8" "" "" "" "" "" "" "" "" "" "" "443.2" "359.3" "409.5" "338.9" "421.5" "423.6" "446.1" "374.5" "358.8" "170.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "397277040626667291" "False" "High" "IsMasterProtein" "Q9UBB4" "Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1" "0.000" "False" "53.210" "22" "8" "17" "8" "475" "53.5" "5.25" "59.11" "8" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09759" "25814" "ENSG00000130638" "ATXN10" "A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4" "" "Ciliopathies" "1" "0" "0.986" "0.791" "1.024" "1.027" "0.871" "0.972" "0.893" "0.840" "0.980" "438.0" "431.8" "346.6" "448.6" "450.0" "381.5" "425.7" "391.3" "368.0" "429.5" "" "" "" "" "" "" "" "" "" "" "395.4" "333.1" "268.1" "302.1" "375.4" "325.6" "361.1" "283.2" "248.2" "429.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "410623999248744867" "False" "High" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "0.000" "False" "53.185" "13" "15" "17" "15" "1096" "123.4" "8.82" "48.67" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383, Pf21071" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "4" "0" "0.975" "1.937" "0.941" "1.044" "1.936" "0.984" "1.023" "1.937" "1.048" "342.1" "333.6" "662.6" "322.0" "357.1" "662.1" "336.7" "349.8" "662.6" "358.5" "" "" "" "" "" "" "" "" "" "" "308.8" "257.4" "512.5" "216.8" "297.9" "565.2" "285.6" "253.2" "446.9" "358.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3084811773954898757" "False" "High" "IsMasterProtein" "Q6BCY4" "NADH-cytochrome b5 reductase 2 OS=Homo sapiens OX=9606 GN=CYB5R2 PE=1 SV=1" "0.000" "False" "53.040" "38" "11" "27" "11" "276" "31.4" "8.50" "80.55" "11" "other metabolic processes;transport" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00175, Pf00970" "51700" "ENSG00000166394" "CYB5R2" "hsa:51700; Q6BCY4; Q9BVA3; Q9UF68; Q9UHJ0" "Erythrocytes take up carbon dioxide and release oxygen" "Oxidation by cytochrome P450" "2" "0" "1.102" "1.050" "0.986" "0.955" "1.129" "0.967" "1.064" "1.103" "0.764" "1250.3" "1378.1" "1312.6" "1232.4" "1194.3" "1411.6" "1208.6" "1329.8" "1378.9" "955.7" "" "" "" "" "" "" "" "" "" "" "1128.6" "1063.0" "1015.2" "829.9" "996.3" "1204.8" "1025.2" "962.4" "930.0" "955.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579275288277334412" "False" "High" "IsMasterProtein" "P46736" "Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2" "0.000" "False" "52.994" "31" "8" "13" "8" "316" "36.0" "5.92" "42.48" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf18110" "79184" "ENSG00000185515" "BRCC3" "A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; hsa:79184; P46736; Q16107; Q53YX5; Q9BTZ6" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "5q35 copy number variation" "6" "0" "1.009" "1.028" "0.978" "0.987" "1.001" "0.964" "1.003" "1.038" "0.780" "299.9" "302.7" "308.4" "293.5" "296.1" "300.2" "289.1" "300.7" "311.5" "234.0" "" "" "" "" "" "" "" "" "" "" "270.8" "233.5" "238.5" "197.6" "247.0" "256.2" "245.3" "217.6" "210.1" "234.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165870367093882655" "False" "High" "IsMasterProtein" "Q86TI2" "Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3" "0.000" "False" "52.974" "12" "9" "13" "8" "863" "98.2" "6.46" "43.16" "9" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "91039" "ENSG00000142002" "DPP9" "hsa:91039; O75273; O75868; Q1ZZB8; Q6AI37; Q6UAL0; Q6ZMT2; Q6ZNJ5; Q86TI2; Q8N2J7; Q8N3F5; Q8WXD8; Q96NT8; Q9BVR3" "" "Lung fibrosis" "1" "1" "1.017" "0.827" "1.018" "0.990" "0.933" "0.944" "0.964" "0.945" "0.903" "630.0" "641.0" "520.9" "641.4" "623.7" "587.9" "594.7" "607.1" "595.1" "568.9" "" "" "" "" "" "" "" "" "" "" "568.7" "494.4" "402.8" "431.9" "520.3" "501.8" "504.5" "439.4" "401.4" "568.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5911471042018297925" "False" "High" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "0.000" "False" "52.939" "23" "7" "14" "7" "463" "50.5" "9.52" "44.80" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "0" "0.954" "0.821" "0.955" "0.886" "0.837" "0.923" "0.912" "0.840" "0.928" "544.0" "519.2" "446.5" "519.3" "481.8" "455.6" "502.2" "495.9" "457.1" "504.7" "" "" "" "" "" "" "" "" "" "" "491.0" "400.5" "345.3" "349.7" "401.9" "388.8" "426.0" "358.9" "308.3" "504.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740771680866674362" "False" "High" "IsMasterProtein" "P62993" "Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1" "0.000" "False" "52.840" "41" "9" "21" "9" "217" "25.2" "6.32" "66.80" "9" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "2885" "ENSG00000177885" "GRB2" "hsa:2885; P29354; P62993; Q14450; Q63057; Q63059" "Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "73" "0" "1.026" "0.944" "0.977" "1.047" "1.096" "0.990" "1.055" "0.981" "0.788" "1074.0" "1102.4" "1013.5" "1049.1" "1124.1" "1177.4" "1063.6" "1133.4" "1053.3" "846.0" "" "" "" "" "" "" "" "" "" "" "969.5" "850.3" "783.9" "706.5" "937.7" "1004.9" "902.3" "820.2" "710.4" "846.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8166763961734876416" "False" "High" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "0.000" "False" "52.769" "18" "8" "28" "6" "409" "43.1" "4.84" "77.33" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; HDAC6 interactions in the central nervous system" "8" "2" "0.963" "1.064" "0.957" "0.979" "1.044" "0.951" "1.030" "1.042" "0.744" "2106.9" "2028.9" "2242.3" "2016.0" "2063.2" "2199.1" "2002.8" "2170.7" "2194.9" "1567.5" "" "" "" "" "" "" "" "" "" "" "1901.8" "1565.0" "1734.3" "1357.6" "1721.0" "1876.9" "1698.9" "1570.9" "1480.4" "1567.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6641856841102683489" "False" "High" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "0.000" "False" "52.715" "25" "5" "32" "5" "216" "24.4" "7.49" "105.32" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Transcriptional regulation by small RNAs; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "11" "0" "0.952" "1.066" "0.812" "1.000" "1.059" "0.973" "0.948" "0.906" "0.748" "2312.3" "2201.3" "2464.6" "1878.5" "2311.2" "2448.8" "2249.4" "2192.0" "2095.4" "1729.5" "" "" "" "" "" "" "" "" "" "" "2087.2" "1698.0" "1906.2" "1265.0" "1927.9" "2090.1" "1908.1" "1586.4" "1413.3" "1729.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9010932242184779008" "False" "High" "IsMasterProtein" "P10644" "cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1" "0.000" "False" "52.636" "25" "9" "13" "7" "381" "43.0" "5.35" "52.66" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5573" "ENSG00000108946" "PRKAR1A" "hsa:5573; K7ER48; P10644; Q567S7" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "27" "2" "1.021" "0.842" "1.029" "1.011" "0.829" "1.022" "1.005" "0.882" "1.038" "853.4" "870.9" "718.9" "878.4" "863.0" "707.6" "871.9" "858.0" "752.8" "885.6" "" "" "" "" "" "" "" "" "" "" "770.3" "671.7" "556.0" "591.5" "719.9" "603.9" "739.6" "620.9" "507.7" "885.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2229585917492551052" "False" "High" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "0.000" "False" "52.619" "10" "10" "17" "10" "1094" "118.2" "7.06" "57.88" "10" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "COPII-mediated vesicle transport; MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "0.958" "1.022" "0.991" "1.079" "0.985" "1.022" "0.934" "0.953" "1.483" "466.8" "447.4" "476.9" "462.8" "503.6" "460.0" "476.9" "436.0" "444.9" "692.4" "" "" "" "" "" "" "" "" "" "" "421.4" "345.1" "368.8" "311.6" "420.1" "392.6" "404.5" "315.5" "300.1" "692.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716088986514922399" "False" "High" "IsMasterProtein" "Q13617" "Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2" "0.000" "False" "52.592" "15" "12" "20" "12" "745" "86.9" "6.92" "53.86" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8453" "ENSG00000108094" "CUL2" "B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation" "Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "6" "0" "1.018" "1.038" "1.003" "0.941" "1.084" "0.977" "1.024" "1.014" "0.800" "825.4" "840.3" "856.4" "827.5" "776.7" "894.7" "806.2" "845.5" "837.3" "660.2" "" "" "" "" "" "" "" "" "" "" "745.0" "648.1" "662.4" "557.3" "647.9" "763.6" "683.9" "611.9" "564.8" "660.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838568104168178339" "False" "High" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "0.000" "False" "52.590" "22" "9" "13" "9" "463" "51.8" "5.45" "43.85" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "Hijack of ubiquitination by SARS-CoV-2" "5" "0" "0.906" "0.799" "0.896" "0.857" "0.841" "0.872" "0.861" "0.807" "0.825" "494.7" "448.2" "395.4" "443.5" "424.0" "415.9" "431.4" "425.7" "399.1" "408.1" "" "" "" "" "" "" "" "" "" "" "446.5" "345.7" "305.8" "298.6" "353.7" "354.9" "366.0" "308.1" "269.2" "408.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033578792166200150" "False" "High" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "0.000" "False" "52.539" "20" "6" "17" "5" "332" "36.2" "8.21" "63.25" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "" "Pre-implantation embryo; mRNA processing" "2" "0" "1.089" "1.239" "1.025" "1.065" "1.229" "1.047" "1.170" "1.189" "0.803" "830.8" "904.5" "1029.5" "851.5" "884.5" "1020.7" "869.6" "971.7" "987.5" "667.4" "" "" "" "" "" "" "" "" "" "" "749.9" "697.7" "796.2" "573.4" "737.8" "871.2" "737.6" "703.2" "666.1" "667.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6856624260157841827" "False" "High" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "0.000" "False" "52.452" "27" "8" "13" "7" "369" "40.9" "7.44" "43.18" "8" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "1" "0.985" "0.942" "0.956" "0.953" "0.937" "1.009" "1.005" "1.016" "0.724" "828.2" "816.0" "779.8" "791.6" "789.6" "775.8" "836.0" "832.5" "841.1" "599.6" "" "" "" "" "" "" "" "" "" "" "747.6" "629.4" "603.2" "533.1" "658.6" "662.2" "709.2" "602.4" "567.3" "599.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5217508454541550081" "False" "High" "IsMasterProtein" "P50453" "Serpin B9 OS=Homo sapiens OX=9606 GN=SERPINB9 PE=1 SV=1" "0.000" "False" "52.451" "29" "10" "20" "10" "376" "42.4" "5.86" "56.25" "10" "other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5272" "ENSG00000170542" "SERPINB9" "B2RBW3; hsa:5272; P50453; Q5TD03" "" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "2" "0" "1.077" "1.151" "1.057" "1.106" "1.179" "1.117" "1.048" "1.167" "0.730" "423.0" "455.6" "486.8" "447.1" "467.9" "498.8" "472.4" "443.2" "493.7" "308.8" "" "" "" "" "" "" "" "" "" "" "381.9" "351.4" "376.5" "301.1" "390.3" "425.7" "400.7" "320.7" "333.0" "308.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377635877244790923" "False" "High" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "0.000" "False" "52.412" "30" "9" "19" "3" "323" "37.0" "6.54" "60.72" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "17" "0" "0.976" "0.994" "1.054" "0.896" "0.991" "0.956" "0.933" "1.043" "0.867" "395.3" "385.9" "392.8" "416.7" "354.0" "391.6" "377.7" "368.9" "412.4" "342.7" "" "" "" "" "" "" "" "" "" "" "356.8" "297.6" "303.8" "280.6" "295.3" "334.3" "320.4" "267.0" "278.2" "342.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4457645785715096452" "False" "High" "IsMasterProtein" "Q9BS26" "Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1" "0.000" "False" "52.369" "23" "9" "18" "8" "406" "46.9" "5.26" "58.48" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "23071" "ENSG00000023318" "ERP44" "hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26" "Neutrophil degranulation" "" "1" "0" "1.030" "1.105" "1.044" "0.951" "1.218" "1.028" "0.967" "1.272" "0.935" "335.2" "345.3" "370.5" "350.0" "318.7" "408.1" "344.7" "324.3" "426.4" "313.3" "" "" "" "" "" "" "" "" "" "" "302.6" "266.3" "286.6" "235.7" "265.9" "348.3" "292.4" "234.7" "287.6" "313.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1997849162023251854" "False" "High" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "0.000" "False" "52.355" "44" "7" "23" "7" "163" "18.6" "4.54" "69.11" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Nuclear events stimulated by ALK signaling in cancer; Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "39" "0" "0.995" "0.895" "0.934" "0.902" "0.868" "0.969" "1.024" "0.825" "0.604" "1661.6" "1652.9" "1486.3" "1552.2" "1499.5" "1442.5" "1609.8" "1700.7" "1371.1" "1004.1" "" "" "" "" "" "" "" "" "" "" "1499.9" "1275.0" "1149.6" "1045.2" "1250.8" "1231.2" "1365.6" "1230.8" "924.8" "1004.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8599582728715422228" "False" "High" "IsMasterProtein" "Q01432" "AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1" "0.000" "False" "52.339" "15" "12" "13" "11" "767" "88.8" "6.98" "45.36" "12" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf19326" "272" "ENSG00000133805" "AMPD3" "A0AUX0; B7Z2S2; B7Z763; B7Z877; hsa:272; Q01432" "Neutrophil degranulation; Purine salvage" "" "2" "1" "1.029" "1.004" "1.031" "1.015" "0.940" "1.006" "1.040" "0.981" "0.797" "866.1" "891.3" "869.7" "893.1" "878.9" "814.3" "871.1" "900.8" "849.8" "690.6" "" "" "" "" "" "" "" "" "" "" "781.8" "687.5" "672.7" "601.4" "733.1" "695.0" "738.9" "651.9" "573.1" "690.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5272844491039920934" "False" "High" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "0.000" "False" "52.068" "29" "7" "14" "7" "255" "28.4" "8.62" "46.00" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "mRNA processing" "3" "0" "0.980" "0.906" "1.024" "0.957" "0.943" "0.975" "1.030" "0.918" "0.706" "928.5" "909.7" "841.4" "950.3" "888.7" "875.3" "905.2" "956.0" "852.0" "655.4" "" "" "" "" "" "" "" "" "" "" "838.1" "701.7" "650.8" "639.9" "741.3" "747.1" "767.8" "691.9" "574.6" "655.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3011469150095823870" "False" "High" "IsMasterProtein" "Q9Y696" "Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4" "0.000" "False" "52.043" "31" "6" "18" "6" "253" "28.8" "5.59" "54.38" "6" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409" "25932" "ENSG00000169504" "CLIC4" "hsa:25932; Q9UFW9; Q9UQJ6; Q9Y696" "" "" "0" "0" "1.018" "0.976" "0.952" "1.028" "1.011" "1.008" "0.981" "1.055" "0.873" "545.5" "555.6" "532.2" "519.1" "560.6" "551.7" "549.9" "535.4" "575.8" "476.0" "" "" "" "" "" "" "" "" "" "" "492.5" "428.5" "411.6" "349.6" "467.6" "470.9" "466.5" "387.4" "388.4" "476.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-573717286669998035" "False" "High" "IsMasterProtein" "Q9BY43" "Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3" "0.000" "False" "52.013" "38" "8" "15" "8" "222" "25.1" "4.70" "51.11" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "29082" "ENSG00000254505; ENSG00000285302" "CHMP4A" "hsa:29082; Q14D22; Q32Q79; Q86SZ8; Q96QJ9; Q9BY43; Q9P026" "HCMV Late Events; Late endosomal microautophagy; Pyroptosis; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "1.009" "0.866" "0.980" "0.932" "0.877" "0.926" "1.021" "0.861" "0.608" "1696.8" "1712.6" "1468.8" "1662.0" "1581.0" "1488.9" "1571.4" "1733.2" "1461.3" "1031.7" "" "" "" "" "" "" "" "" "" "" "1531.7" "1321.0" "1136.0" "1119.2" "1318.8" "1270.8" "1333.0" "1254.3" "985.7" "1031.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8447148284608472051" "False" "High" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "0.000" "False" "51.852" "41" "9" "17" "9" "224" "24.9" "4.82" "51.39" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "HCMV Late Events; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "1.040" "0.869" "1.016" "0.987" "0.906" "0.994" "1.078" "0.846" "0.619" "1212.0" "1260.0" "1053.1" "1231.6" "1195.6" "1098.4" "1205.3" "1306.5" "1025.5" "750.2" "" "" "" "" "" "" "" "" "" "" "1094.0" "971.9" "814.5" "829.4" "997.4" "937.5" "1022.4" "945.5" "691.7" "750.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2192359693732382121" "False" "High" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "0.000" "False" "51.694" "30" "10" "20" "10" "338" "38.3" "5.53" "61.84" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "1" "0" "0.945" "0.782" "0.879" "0.922" "0.804" "0.911" "0.925" "0.742" "1.000" "1009.1" "953.1" "789.2" "887.0" "930.0" "810.8" "919.7" "933.2" "748.5" "1009.0" "" "" "" "" "" "" "" "" "" "" "910.8" "735.2" "610.4" "597.3" "775.8" "692.0" "780.2" "675.4" "504.8" "1009.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5866289401045489846" "False" "High" "IsMasterProtein" "Q92616" "Stalled ribosome sensor GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=7" "0.000" "False" "51.677" "6" "14" "15" "14" "2671" "292.5" "7.43" "42.24" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "" "10985" "ENSG00000089154" "GCN1" "A8KAY1; hsa:10985; O95001; O95651; Q6P2S3; Q86X65; Q8N5I5; Q8WU80; Q92616; Q99736; Q9UE60" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "" "1" "0" "1.202" "0.959" "1.066" "0.980" "1.023" "1.024" "0.423" "1.144" "9.876" "133.7" "160.8" "128.2" "142.5" "131.0" "136.8" "136.9" "56.6" "153.0" "1320.3" "" "" "" "" "" "" "" "" "" "" "120.7" "124.0" "99.2" "96.0" "109.3" "116.8" "116.1" "41.0" "103.2" "1320.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7644336301377244123" "False" "High" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "0.000" "False" "51.649" "12" "8" "13" "8" "802" "85.1" "6.79" "43.35" "8" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "1.026" "1.016" "1.099" "1.053" "1.071" "1.039" "1.044" "1.092" "0.858" "764.0" "783.4" "776.2" "839.7" "804.6" "818.1" "793.7" "797.5" "834.4" "655.8" "" "" "" "" "" "" "" "" "" "" "689.6" "604.3" "600.3" "565.5" "671.1" "698.3" "673.3" "577.1" "562.8" "655.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3101677286908017403" "False" "High" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "0.000" "False" "51.570" "16" "9" "10" "9" "684" "75.4" "6.61" "34.68" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "1.006" "0.887" "0.975" "0.953" "0.830" "1.026" "1.010" "0.930" "0.936" "465.3" "468.3" "412.8" "453.8" "443.6" "386.3" "477.6" "469.8" "432.7" "435.7" "" "" "" "" "" "" "" "" "" "" "420.0" "361.2" "319.2" "305.6" "370.1" "329.8" "405.1" "340.0" "291.8" "435.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585678134614880292" "False" "High" "IsMasterProtein" "Q9NTK5" "Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2" "0.000" "False" "51.459" "29" "11" "24" "11" "396" "44.7" "7.81" "74.84" "11" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "translation activity;other molecular function" "Pf01926, Pf06071" "29789" "ENSG00000138430" "OLA1" "D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4" "Platelet degranulation" "" "1" "0" "1.010" "0.787" "1.017" "0.990" "0.725" "1.080" "1.027" "0.745" "0.769" "1950.6" "1969.3" "1535.9" "1984.6" "1930.8" "1414.9" "2107.5" "2003.5" "1452.3" "1499.8" "" "" "" "" "" "" "" "" "" "" "1760.7" "1519.0" "1188.0" "1336.4" "1610.6" "1207.6" "1787.7" "1449.9" "979.6" "1499.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739284738644474323" "False" "High" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "0.000" "False" "51.452" "15" "10" "14" "6" "689" "79.5" "7.28" "45.37" "10" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "Cargo recognition for clathrin-mediated endocytosis; G alpha (q) signalling events; Activation of SMO; G alpha (s) signalling events; Calmodulin induced events" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway; HDAC6 interactions in the central nervous system" "9" "3" "1.030" "0.765" "1.012" "1.055" "0.851" "1.039" "0.977" "0.823" "0.859" "753.2" "775.9" "576.2" "762.0" "794.3" "641.0" "782.6" "735.9" "619.7" "646.9" "" "" "" "" "" "" "" "" "" "" "679.9" "598.5" "445.6" "513.1" "662.6" "547.1" "663.9" "532.6" "418.0" "646.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5004824679755995217" "False" "High" "IsMasterProtein" "Q13867" "Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1" "0.000" "False" "51.298" "16" "6" "21" "6" "455" "52.5" "6.27" "52.69" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03051" "642" "ENSG00000108578" "BLMH" "B2R796; hsa:642; Q13867; Q53F86; Q9UER9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.058" "1.046" "1.041" "0.963" "1.163" "0.960" "1.024" "1.138" "0.787" "385.4" "407.6" "403.0" "401.3" "371.3" "448.1" "370.1" "394.8" "438.6" "303.5" "" "" "" "" "" "" "" "" "" "" "347.9" "314.4" "311.7" "270.2" "309.8" "382.5" "313.9" "285.7" "295.9" "303.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000149413272750326" "False" "High" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "0.000" "False" "51.297" "47" "10" "17" "10" "218" "24.5" "5.94" "56.26" "10" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "RAB geranylgeranylation; TBC/RABGAPs" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; Vasopressin-regulated water reabsorption" "5" "0" "0.969" "1.124" "1.004" "0.971" "1.163" "0.953" "1.034" "1.103" "0.778" "1467.8" "1422.1" "1650.3" "1473.9" "1424.6" "1707.2" "1398.8" "1517.4" "1619.6" "1141.3" "" "" "" "" "" "" "" "" "" "" "1324.9" "1096.9" "1276.4" "992.5" "1188.4" "1457.1" "1186.6" "1098.2" "1092.4" "1141.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4267649636453152821" "False" "High" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "0.000" "False" "51.231" "45" "9" "39" "9" "149" "17.3" "5.97" "115.26" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Nuclear signaling by ERBB4" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "7" "0" "0.966" "1.107" "1.024" "0.864" "1.007" "1.035" "1.168" "0.916" "0.628" "3209.9" "3099.9" "3553.1" "3285.5" "2772.0" "3231.3" "3321.6" "3749.8" "2940.6" "2015.1" "" "" "" "" "" "" "" "" "" "" "2897.5" "2391.1" "2748.1" "2212.5" "2312.3" "2758.0" "2817.7" "2713.7" "1983.4" "2015.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8882666347281850930" "False" "High" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "0.000" "False" "51.214" "32" "9" "15" "7" "271" "31.5" "6.87" "49.33" "9" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "PI and PC transport between ER and Golgi membranes" "" "1" "0" "0.969" "1.023" "0.899" "1.000" "1.061" "0.932" "0.982" "1.050" "0.813" "700.9" "679.0" "717.1" "629.8" "701.0" "743.9" "653.0" "688.1" "736.1" "569.8" "" "" "" "" "" "" "" "" "" "" "632.7" "523.7" "554.6" "424.1" "584.7" "634.9" "553.9" "498.0" "496.5" "569.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845069297566421061" "False" "High" "IsMasterProtein" "P35221" "Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1" "0.000" "False" "51.107" "13" "10" "13" "10" "906" "100.0" "6.29" "42.05" "10" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "1495" "ENSG00000044115" "CTNNA1" "hsa:1495; P35221; Q12795; Q8N1C0" "RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "15" "0" "1.019" "0.883" "1.011" "0.983" "0.844" "0.937" "0.964" "0.883" "0.870" "560.9" "571.7" "495.2" "567.1" "551.2" "473.6" "525.4" "540.9" "495.4" "488.2" "" "" "" "" "" "" "" "" "" "" "506.3" "441.0" "383.0" "381.9" "459.8" "404.2" "445.7" "391.4" "334.1" "488.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479790111935506116" "False" "High" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "0.000" "False" "51.086" "21" "11" "22" "11" "522" "56.0" "8.78" "66.86" "11" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.024" "1.094" "1.007" "1.025" "1.099" "1.076" "1.050" "1.038" "0.876" "1436.7" "1471.0" "1571.5" "1447.5" "1472.3" "1578.8" "1545.7" "1508.2" "1490.9" "1258.1" "" "" "" "" "" "" "" "" "" "" "1296.9" "1134.6" "1215.5" "974.7" "1228.1" "1347.5" "1311.2" "1091.4" "1005.6" "1258.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2746028524908130600" "False" "High" "IsMasterProtein" "P16070" "CD44 antigen OS=Homo sapiens OX=9606 GN=CD44 PE=1 SV=3" "0.000" "False" "50.937" "11" "6" "16" "6" "742" "81.5" "5.33" "58.83" "6" "cell adhesion;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00193" "960" "ENSG00000026508" "CD44" "A5YRN9; B6EAT9; D3DR12; D3DR13; hsa:960; O95370; P16070; P22511; Q04858; Q13419; Q13957; Q13958; Q13959; Q13960; Q13961; Q13967; Q13968; Q13980; Q15861; Q16064; Q16065; Q16066; Q16208; Q16522; Q86T72; Q86Z27; Q8N694; Q92493; Q96J24; Q9H5A5; Q9UC28; Q9UC29; Q9UC30; Q9UCB0; Q9UJ36" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Degradation of the extracellular matrix; Integrin cell surface interactions; Interferon gamma signaling; Hyaluronan uptake and degradation" "Hepatitis C and hepatocellular carcinoma; Wnt signaling pathway and pluripotency; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Pleural mesothelioma; CCL18 signaling pathway" "12" "0" "1.041" "1.091" "1.151" "1.055" "0.994" "1.043" "1.049" "0.980" "0.654" "481.3" "500.9" "525.2" "553.9" "508.0" "478.4" "502.1" "505.0" "471.9" "314.6" "" "" "" "" "" "" "" "" "" "" "434.5" "386.3" "406.2" "373.0" "423.7" "408.3" "425.9" "365.5" "318.3" "314.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771737938610614120" "False" "High" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "0.000" "False" "50.878" "13" "10" "14" "10" "881" "96.7" "4.55" "40.59" "10" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "COPII-mediated vesicle transport" "" "1" "0" "0.993" "0.802" "1.036" "0.986" "0.775" "1.028" "0.986" "0.844" "1.102" "733.8" "728.9" "588.8" "760.4" "723.5" "569.0" "754.1" "723.6" "619.3" "808.5" "" "" "" "" "" "" "" "" "" "" "662.4" "562.3" "455.4" "512.1" "603.6" "485.7" "639.7" "523.7" "417.7" "808.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7590147556392166876" "False" "High" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "0.000" "False" "50.846" "16" "12" "14" "12" "714" "81.8" "5.67" "44.53" "12" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "P07384; Q2TTR0; Q6DHV4" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "7" "0" "1.053" "1.043" "1.033" "1.049" "1.159" "1.027" "1.036" "1.096" "0.757" "530.7" "558.7" "553.3" "548.3" "556.7" "614.8" "544.8" "549.6" "581.5" "401.8" "" "" "" "" "" "" "" "" "" "" "479.0" "430.9" "428.0" "369.2" "464.4" "524.8" "462.2" "397.7" "392.2" "401.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7804593392060362224" "False" "High" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "0.000" "False" "50.839" "16" "7" "28" "7" "419" "48.2" "6.15" "92.18" "7" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "9" "0" "0.894" "0.949" "0.858" "0.828" "0.907" "0.760" "0.748" "0.925" "1.042" "2296.9" "2052.3" "2179.7" "1969.6" "1901.4" "2084.0" "1745.7" "1717.5" "2123.6" "2394.1" "" "" "" "" "" "" "" "" "" "" "2073.3" "1583.0" "1685.9" "1326.3" "1586.1" "1778.7" "1480.8" "1243.0" "1432.3" "2394.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4191413839330820481" "False" "High" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "0.000" "False" "50.829" "20" "7" "18" "6" "420" "46.4" "9.57" "60.27" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "0" "1.089" "1.207" "0.987" "1.006" "1.300" "0.996" "1.152" "1.156" "0.973" "556.1" "605.5" "671.2" "548.9" "559.2" "722.7" "553.6" "640.4" "642.8" "541.1" "" "" "" "" "" "" "" "" "" "" "501.9" "467.1" "519.1" "369.7" "466.5" "616.9" "469.6" "463.4" "433.6" "541.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6134268530089920080" "False" "High" "IsMasterProtein" "P09668" "Pro-cathepsin H OS=Homo sapiens OX=9606 GN=CTSH PE=1 SV=4" "0.000" "False" "50.759" "20" "6" "16" "6" "335" "37.4" "8.07" "51.17" "6" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1512" "ENSG00000103811" "CTSH" "B2RBK0; hsa:1512; P09668; Q96NY6; Q9BUM7" "Neutrophil degranulation; MHC class II antigen presentation; Surfactant metabolism" "" "3" "0" "1.029" "1.118" "0.925" "1.124" "1.243" "0.878" "0.963" "1.109" "0.710" "631.4" "649.4" "706.2" "583.8" "709.4" "784.5" "554.6" "608.3" "700.2" "448.6" "" "" "" "" "" "" "" "" "" "" "569.9" "500.9" "546.2" "393.1" "591.7" "669.6" "470.5" "440.2" "472.2" "448.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2273417600798469774" "False" "High" "IsMasterProtein" "Q10570" "Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2" "0.000" "False" "50.662" "7" "9" "12" "9" "1443" "160.8" "6.40" "37.17" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "29894" "ENSG00000071894; ENSG00000285049" "CPSF1" "hsa:29894; Q10570; Q96AF0" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "7" "0" "1.008" "1.063" "0.971" "1.059" "1.196" "1.078" "1.023" "1.236" "1.025" "198.4" "200.1" "210.9" "192.7" "210.0" "237.4" "213.9" "202.9" "245.2" "203.3" "" "" "" "" "" "" "" "" "" "" "179.1" "154.3" "163.1" "129.8" "175.2" "202.6" "181.5" "146.9" "165.4" "203.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9201428938326541883" "False" "High" "IsMasterProtein" "Q15291" "Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2" "0.000" "False" "50.587" "19" "9" "11" "9" "538" "59.1" "5.10" "37.71" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00400" "5929" "ENSG00000117222" "RBBP5" "A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Kleefstra syndrome" "8" "0" "0.958" "0.920" "0.945" "0.965" "0.994" "0.956" "0.983" "0.943" "0.822" "633.6" "606.9" "582.6" "598.6" "611.4" "629.7" "605.8" "622.7" "597.8" "520.7" "" "" "" "" "" "" "" "" "" "" "571.9" "468.1" "450.6" "403.1" "510.0" "537.4" "513.9" "450.7" "403.2" "520.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664537344047956195" "False" "High" "IsMasterProtein" "Q08209" "Protein phosphatase 3 catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "0.000" "False" "50.583" "15" "8" "19" "3" "521" "58.7" "5.86" "62.07" "8" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Ca2+ pathway; Calcineurin activates NFAT; DARPP-32 events" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "26" "5" "0.966" "0.938" "1.037" "0.965" "0.968" "0.975" "1.020" "0.958" "0.751" "820.7" "792.9" "769.7" "850.8" "791.7" "794.3" "799.8" "837.0" "786.3" "616.2" "" "" "" "" "" "" "" "" "" "" "740.8" "611.6" "595.3" "572.9" "660.4" "677.9" "678.5" "605.7" "530.4" "616.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2214301499697937672" "False" "High" "IsMasterProtein" "Q96C86" "m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2" "0.000" "False" "50.564" "27" "9" "16" "9" "337" "38.6" "6.38" "53.53" "9" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05652, Pf11969" "28960" "ENSG00000110063" "DCPS" "hsa:28960; Q8NHL8; Q96C86; Q9Y2S5" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "1.012" "1.056" "0.971" "1.073" "1.054" "1.000" "0.984" "1.075" "0.693" "1007.2" "1019.2" "1063.3" "978.0" "1080.8" "1061.2" "1007.1" "990.8" "1082.7" "698.3" "" "" "" "" "" "" "" "" "" "" "909.2" "786.2" "822.4" "658.6" "901.6" "905.7" "854.3" "717.1" "730.3" "698.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3684476333316036577" "False" "High" "IsMasterProtein" "Q5R372" "Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1" "0.000" "False" "50.531" "16" "12" "16" "11" "815" "92.5" "5.31" "49.89" "12" "transport;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00566, Pf00640, Pf12473" "9910" "ENSG00000152061" "RABGAP1L" "O75059; Q3ZTR8; Q5R369; Q5R372; Q8IVV0; Q8N921; Q8WV78; Q9NSP8; Q9UQ19; Q9UQP5; Q9Y6Y5; Q9Y6Y6" "" "" "0" "1" "0.968" "0.964" "0.866" "0.992" "0.994" "0.972" "0.925" "0.933" "1.076" "709.5" "686.9" "684.0" "614.2" "704.2" "705.1" "689.4" "656.5" "662.2" "763.5" "" "" "" "" "" "" "" "" "" "" "640.5" "529.8" "529.0" "413.6" "587.4" "601.8" "584.8" "475.1" "446.7" "763.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4008936127769007747" "False" "High" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "0.000" "False" "50.482" "10" "14" "14" "14" "1243" "140.3" "8.22" "45.27" "14" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "0.953" "0.704" "0.831" "0.904" "0.757" "0.940" "1.017" "0.721" "0.753" "1074.3" "1023.9" "755.9" "892.7" "971.4" "813.0" "1009.4" "1092.3" "774.3" "809.4" "" "" "" "" "" "" "" "" "" "" "969.7" "789.7" "584.6" "601.1" "810.3" "693.9" "856.2" "790.5" "522.3" "809.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5820221568948669859" "False" "High" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "0.000" "False" "50.467" "44" "8" "20" "8" "183" "20.9" "7.69" "63.39" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; TGF-beta receptor signaling activates SMADs" "" "5" "0" "1.061" "0.977" "0.989" "1.015" "0.988" "1.061" "1.049" "0.980" "0.920" "1409.2" "1495.7" "1376.7" "1393.1" "1429.7" "1391.9" "1495.5" "1477.7" "1380.4" "1296.8" "" "" "" "" "" "" "" "" "" "" "1272.1" "1153.7" "1064.8" "938.1" "1192.6" "1188.0" "1268.6" "1069.4" "931.0" "1296.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3138004166962983246" "False" "High" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "0.000" "False" "50.466" "26" "7" "41" "4" "251" "28.8" "4.06" "117.84" "7" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "0" "0.993" "1.078" "1.025" "0.985" "1.063" "1.007" "0.986" "1.136" "0.785" "619.3" "615.0" "667.3" "634.7" "609.7" "658.0" "623.9" "610.3" "703.3" "486.2" "" "" "" "" "" "" "" "" "" "" "559.0" "474.4" "516.1" "427.4" "508.6" "561.6" "529.2" "441.7" "474.4" "486.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1447147241946060131" "False" "High" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "0.000" "False" "50.303" "68" "8" "52" "8" "102" "10.9" "8.92" "151.10" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "RHOG GTPase cycle" "" "1" "0" "0.973" "1.094" "0.960" "0.923" "1.036" "1.011" "1.037" "1.034" "0.586" "3756.5" "3656.7" "4109.8" "3607.6" "3465.8" "3893.4" "3797.8" "3894.0" "3885.0" "2199.5" "" "" "" "" "" "" "" "" "" "" "3390.8" "2820.5" "3178.6" "2429.3" "2891.1" "3323.0" "3221.6" "2818.0" "2620.4" "2199.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366486650245995426" "False" "High" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "0.000" "False" "50.270" "20" "11" "15" "11" "647" "69.0" "7.84" "42.55" "11" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "8" "0" "1.006" "0.852" "1.028" "0.987" "0.865" "0.989" "0.959" "0.866" "0.691" "705.6" "710.1" "601.1" "725.1" "696.3" "610.2" "697.9" "676.9" "610.9" "487.9" "" "" "" "" "" "" "" "" "" "" "637.0" "547.7" "464.9" "488.3" "580.9" "520.8" "592.0" "489.9" "412.1" "487.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866908035804814240" "False" "High" "IsMasterProtein" "P22059" "Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1" "0.000" "False" "50.230" "14" "11" "18" "11" "807" "89.4" "7.30" "55.90" "11" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "5007" "ENSG00000110048" "OSBP" "hsa:5007; P22059; Q6P524" "Sphingolipid de novo biosynthesis; Synthesis of bile acids and bile salts" "" "2" "0" "0.974" "0.887" "0.924" "0.974" "1.001" "0.931" "0.972" "0.884" "0.909" "777.3" "756.9" "689.6" "718.0" "757.3" "778.2" "723.3" "755.5" "686.8" "706.6" "" "" "" "" "" "" "" "" "" "" "701.7" "583.8" "533.4" "483.5" "631.7" "664.2" "613.6" "546.8" "463.2" "706.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996952704107557877" "False" "High" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "0.000" "False" "50.226" "11" "6" "11" "6" "727" "79.4" "6.23" "44.41" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "1.032" "1.235" "1.021" "1.011" "1.331" "1.009" "1.087" "1.338" "0.581" "359.0" "370.4" "443.5" "366.6" "362.8" "477.8" "362.3" "390.3" "480.2" "208.7" "" "" "" "" "" "" "" "" "" "" "324.0" "285.7" "343.0" "246.9" "302.6" "407.8" "307.3" "282.5" "323.9" "208.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7172207260123364247" "False" "High" "IsMasterProtein" "P11172" "Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1" "0.000" "False" "50.158" "24" "13" "22" "13" "480" "52.2" "7.24" "68.31" "13" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00156, Pf00215" "7372" "ENSG00000114491" "UMPS" "B5LY68; B5LY72; hsa:7372; O00758; O00759; O00760; P11172; Q16862; Q9H3Q2; Q9UG49" "Pyrimidine biosynthesis" "Fluoropyrimidine activity; Pyrimidine metabolism" "3" "0" "1.003" "0.704" "0.975" "0.993" "0.736" "1.041" "1.004" "0.754" "0.709" "1362.6" "1367.0" "958.6" "1328.0" "1353.3" "1002.6" "1418.7" "1368.2" "1026.8" "965.7" "" "" "" "" "" "" "" "" "" "" "1229.9" "1054.4" "741.4" "894.2" "1128.9" "855.8" "1203.5" "990.1" "692.6" "965.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "721169718826189063" "False" "High" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "0.000" "False" "50.149" "11" "14" "23" "14" "1150" "132.7" "5.76" "69.89" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "mRNA Splicing - Major Pathway" "" "1" "0" "0.977" "0.749" "1.015" "0.963" "0.661" "0.947" "0.948" "0.779" "0.914" "1045.1" "1020.9" "782.9" "1060.8" "1006.5" "691.0" "989.4" "991.0" "813.6" "955.4" "" "" "" "" "" "" "" "" "" "" "943.4" "787.5" "605.5" "714.3" "839.6" "589.8" "839.3" "717.2" "548.8" "955.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155444033397587021" "False" "High" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "0.000" "False" "50.141" "18" "7" "11" "7" "439" "48.9" "5.29" "40.21" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.062" "1.019" "1.098" "1.013" "1.014" "1.048" "0.977" "1.014" "0.583" "796.6" "846.0" "811.4" "874.4" "806.8" "807.3" "834.4" "778.2" "808.1" "464.4" "" "" "" "" "" "" "" "" "" "" "719.0" "652.6" "627.6" "588.8" "673.0" "689.1" "707.8" "563.2" "545.0" "464.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8670958433918101160" "False" "High" "IsMasterProtein" "P26373" "Large ribosomal subunit protein eL13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "0.000" "False" "49.981" "36" "9" "18" "9" "211" "24.2" "11.65" "50.69" "9" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.852" "1.001" "0.887" "0.964" "0.894" "0.935" "0.957" "0.962" "0.308" "1448.9" "1234.5" "1449.7" "1284.7" "1396.3" "1295.8" "1354.2" "1386.4" "1394.0" "446.3" "" "" "" "" "" "" "" "" "" "" "1307.9" "952.2" "1121.3" "865.1" "1164.8" "1106.0" "1148.7" "1003.3" "940.2" "446.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7640891103846222335" "False" "High" "IsMasterProtein" "O94819" "Kelch repeat and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=KBTBD11 PE=1 SV=1" "0.000" "False" "49.956" "23" "10" "10" "10" "623" "65.7" "6.07" "37.40" "10" "" "" "" "Pf00651, Pf01344" "9920" "ENSG00000176595; ENSG00000273645" "KBTBD11" "hsa:9920; O94819; Q3L1I0" "" "" "0" "0" "1.194" "0.862" "1.058" "1.250" "0.871" "1.108" "0.991" "1.062" "1.339" "115.7" "138.1" "99.7" "122.4" "144.6" "100.8" "128.2" "114.7" "122.9" "154.9" "" "" "" "" "" "" "" "" "" "" "104.5" "106.5" "77.1" "82.4" "120.6" "86.0" "108.7" "83.0" "82.9" "154.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6534553132144552728" "False" "High" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "0.000" "False" "49.922" "21" "8" "21" "3" "425" "47.6" "4.89" "69.15" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "Potential therapeutics for SARS; HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; RNA Polymerase I Transcription Initiation; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in progeria; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "28" "0" "1.003" "1.228" "1.098" "1.078" "1.196" "1.102" "1.007" "1.251" "1.143" "412.1" "413.4" "506.0" "452.4" "444.2" "492.8" "453.9" "414.8" "515.6" "471.1" "" "" "" "" "" "" "" "" "" "" "372.0" "318.9" "391.4" "304.6" "370.5" "420.6" "385.1" "300.2" "347.8" "471.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6370225409205057848" "False" "High" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "0.000" "False" "49.879" "19" "9" "16" "9" "559" "59.8" "5.29" "49.10" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "mRNA Splicing - Major Pathway" "" "1" "0" "0.990" "1.004" "1.026" "1.024" "1.099" "0.968" "0.854" "1.092" "1.516" "641.1" "634.7" "643.6" "657.9" "656.3" "704.5" "620.9" "547.2" "700.1" "972.0" "" "" "" "" "" "" "" "" "" "" "578.7" "489.6" "497.8" "443.0" "547.4" "601.3" "526.7" "396.0" "472.2" "972.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2914348929085593862" "False" "High" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "0.000" "False" "49.878" "9" "12" "16" "7" "1278" "148.3" "7.31" "52.02" "12" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "Fragile X syndrome; Regulation of actin cytoskeleton" "7" "4" "0.984" "0.820" "1.008" "0.984" "0.787" "0.996" "0.975" "0.849" "1.044" "1166.2" "1147.2" "956.2" "1175.2" "1147.7" "917.6" "1161.8" "1136.7" "990.2" "1217.5" "" "" "" "" "" "" "" "" "" "" "1052.7" "884.9" "739.5" "791.4" "957.3" "783.2" "985.5" "822.6" "667.8" "1217.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3098195104215073585" "False" "High" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "0.000" "False" "49.701" "36" "8" "15" "8" "212" "23.8" "8.27" "52.79" "8" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "3" "0" "1.053" "0.751" "0.992" "1.083" "0.811" "1.099" "1.063" "0.772" "0.743" "784.5" "825.9" "589.2" "778.4" "849.3" "636.4" "862.5" "833.9" "605.7" "582.7" "" "" "" "" "" "" "" "" "" "" "708.1" "637.1" "455.7" "524.2" "708.5" "543.2" "731.6" "603.5" "408.6" "582.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197563919464376950" "False" "High" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "0.000" "False" "49.544" "6" "13" "16" "13" "2240" "243.7" "7.88" "48.41" "13" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "0.986" "1.560" "1.068" "1.085" "1.593" "1.023" "0.944" "1.610" "1.411" "483.1" "476.4" "753.5" "516.1" "524.2" "769.8" "494.1" "455.9" "777.8" "681.7" "" "" "" "" "" "" "" "" "" "" "436.1" "367.5" "582.8" "347.5" "437.3" "657.0" "419.1" "329.9" "524.6" "681.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4758086446517534587" "False" "High" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "0.000" "False" "49.454" "53" "7" "21" "7" "118" "13.5" "9.91" "64.36" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "mRNA processing" "5" "0" "0.952" "1.100" "0.987" "0.997" "1.049" "0.955" "0.913" "1.006" "0.763" "1165.3" "1109.6" "1282.3" "1149.7" "1162.2" "1222.7" "1112.9" "1064.2" "1172.3" "888.8" "" "" "" "" "" "" "" "" "" "" "1051.9" "855.9" "991.8" "774.2" "969.4" "1043.6" "944.1" "770.2" "790.7" "888.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5390020710088679993" "False" "High" "IsMasterProtein" "O75368" "Adapter SH3BGRL OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1" "0.000" "False" "49.394" "46" "6" "26" "6" "114" "12.8" "5.25" "81.94" "6" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04908" "6451" "ENSG00000131171" "SH3BGRL" "hsa:6451; O75368; Q3SYL1; Q5JT50; Q6FIE8; Q9H0N8" "" "" "0" "0" "1.040" "1.217" "1.050" "1.057" "1.120" "1.097" "1.266" "1.190" "0.787" "2137.2" "2223.1" "2601.5" "2245.1" "2258.2" "2392.6" "2344.2" "2706.1" "2544.2" "1682.1" "" "" "" "" "" "" "" "" "" "" "1929.2" "1714.8" "2012.1" "1511.8" "1883.7" "2042.1" "1988.5" "1958.4" "1716.1" "1682.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3476524128370901588" "False" "High" "IsMasterProtein" "P53634" "Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2" "0.000" "False" "49.392" "15" "5" "11" "5" "463" "51.8" "6.99" "38.60" "5" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08773" "1075" "ENSG00000109861" "CTSC" "A8K7V2; B5MDD5; hsa:1075; P53634; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8" "Neutrophil degranulation; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER" "" "4" "0" "0.917" "1.070" "0.874" "0.879" "1.116" "0.958" "1.031" "1.014" "0.851" "294.0" "269.4" "314.5" "256.8" "258.3" "328.2" "281.5" "303.1" "298.0" "250.1" "" "" "" "" "" "" "" "" "" "" "265.3" "207.8" "243.2" "172.9" "215.5" "280.1" "238.8" "219.3" "201.0" "250.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1188306556528865133" "False" "High" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "0.000" "False" "49.357" "23" "6" "27" "5" "268" "30.0" "5.14" "95.52" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; The role of GTSE1 in G2/M progression after G2 checkpoint; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Microtubule cytoskeleton regulation; HDAC6 interactions in the central nervous system" "16" "1" "1.007" "0.964" "1.060" "0.935" "0.952" "0.974" "0.951" "0.927" "0.901" "1721.3" "1732.5" "1659.9" "1824.6" "1610.0" "1637.9" "1676.1" "1636.5" "1596.1" "1551.2" "" "" "" "" "" "" "" "" "" "" "1553.8" "1336.4" "1283.8" "1228.7" "1343.0" "1397.9" "1421.8" "1184.3" "1076.5" "1551.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-915816600694735360" "False" "High" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "0.000" "False" "49.346" "10" "10" "14" "10" "1071" "123.3" "6.06" "40.75" "10" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition; Maturation of hRSV A proteins" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "19" "0" "0.930" "0.869" "0.912" "0.932" "0.924" "0.948" "0.808" "0.912" "2.650" "696.6" "648.1" "605.1" "635.5" "649.4" "643.8" "660.6" "562.7" "635.3" "1845.8" "" "" "" "" "" "" "" "" "" "" "628.8" "499.9" "468.0" "427.9" "541.7" "549.5" "560.4" "407.2" "428.5" "1845.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2616426161905977358" "False" "High" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "0.000" "False" "49.331" "18" "12" "21" "12" "623" "71.2" "7.37" "55.10" "12" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "NFE2L2 regulating MDR associated enzymes" "VEGFA-VEGFR2 signaling" "2" "0" "1.078" "0.784" "1.019" "1.095" "0.796" "0.979" "0.999" "0.814" "0.786" "1033.5" "1114.1" "809.8" "1053.3" "1132.0" "822.6" "1012.2" "1032.7" "840.9" "812.4" "" "" "" "" "" "" "" "" "" "" "932.9" "859.3" "626.3" "709.3" "944.3" "702.1" "858.6" "747.3" "567.2" "812.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4087674429968217888" "False" "High" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "0.000" "False" "49.277" "11" "11" "16" "2" "937" "104.5" "5.38" "54.73" "11" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "MHC class II antigen presentation; Potential therapeutics for SARS; Recycling pathway of L1; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "20" "0" "1.072" "1.088" "0.985" "1.124" "1.096" "0.911" "1.070" "1.166" "0.987" "86.5" "92.7" "94.1" "85.2" "97.2" "94.8" "78.8" "92.5" "100.8" "85.4" "" "" "" "" "" "" "" "" "" "" "78.1" "71.5" "72.8" "57.3" "81.0" "80.9" "66.8" "66.9" "68.0" "85.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3565723958770546681" "False" "High" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "0.000" "False" "49.141" "8" "12" "13" "12" "1498" "167.3" "5.44" "44.64" "12" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "RND2 GTPase cycle" "" "1" "0" "0.973" "0.880" "1.058" "0.992" "0.900" "0.976" "0.983" "0.879" "0.976" "750.7" "730.3" "660.4" "794.1" "744.6" "676.0" "732.9" "737.9" "660.2" "732.9" "" "" "" "" "" "" "" "" "" "" "677.6" "563.3" "510.8" "534.7" "621.1" "576.9" "621.7" "534.0" "445.3" "732.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2123612860387903516" "False" "High" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "0.000" "False" "48.991" "17" "9" "20" "9" "561" "64.3" "6.86" "59.33" "9" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "6" "0" "1.011" "0.870" "0.994" "1.003" "0.883" "0.974" "1.018" "0.840" "0.753" "1004.7" "1015.5" "874.5" "998.9" "1007.9" "887.5" "978.9" "1022.4" "843.5" "756.3" "" "" "" "" "" "" "" "" "" "" "906.9" "783.3" "676.4" "672.7" "840.8" "757.5" "830.4" "739.9" "569.0" "756.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106966376198238351" "False" "High" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "0.000" "False" "48.945" "10" "4" "17" "4" "656" "68.4" "9.33" "67.79" "4" "" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.008" "1.072" "1.019" "0.964" "1.095" "0.964" "1.001" "1.018" "0.760" "923.4" "931.0" "989.6" "941.0" "889.7" "1011.4" "890.3" "923.9" "939.8" "702.1" "" "" "" "" "" "" "" "" "" "" "833.5" "718.1" "765.4" "633.7" "742.2" "863.3" "755.3" "668.6" "633.9" "702.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6985960340352969870" "False" "High" "IsMasterProtein" "P62714" "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1" "0.000" "False" "48.940" "32" "8" "20" "1" "309" "35.6" "5.43" "60.30" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00149" "5516" "ENSG00000104695" "PPP2CB" "D3DSV4; hsa:5516; P11082; P62714; Q6FHK5" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RAF activation; Negative regulation of MAPK pathway; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Serotonin transporter activity; Dopamine metabolism; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; Exercise-induced circadian regulation; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Monoamine transport" "45" "0" "0.984" "1.066" "1.169" "1.143" "0.945" "0.935" "0.936" "0.868" "0.768" "132.8" "130.6" "141.6" "155.2" "151.8" "125.5" "124.2" "124.3" "115.3" "102.0" "" "" "" "" "" "" "" "" "" "" "119.9" "100.7" "109.5" "104.5" "126.6" "107.1" "105.4" "90.0" "77.7" "102.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017068245716453317" "False" "High" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "0.000" "False" "48.893" "12" "12" "17" "6" "977" "107.5" "7.03" "50.91" "12" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "21" "5" "1.028" "1.180" "0.978" "1.069" "1.262" "0.936" "1.000" "1.151" "1.001" "1013.2" "1042.0" "1195.2" "991.4" "1082.6" "1278.3" "948.4" "1013.4" "1165.8" "1013.8" "" "" "" "" "" "" "" "" "" "" "914.6" "803.8" "924.4" "667.6" "903.1" "1091.0" "804.5" "733.4" "786.3" "1013.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6094529598036827804" "False" "High" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "0.000" "False" "48.825" "41" "6" "15" "6" "181" "20.6" "8.87" "60.98" "6" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "Neutrophil degranulation" "" "1" "0" "0.960" "1.053" "0.992" "0.895" "0.965" "0.960" "1.066" "1.087" "0.665" "946.0" "908.5" "995.7" "938.7" "847.1" "913.2" "908.3" "1008.5" "1028.3" "629.4" "" "" "" "" "" "" "" "" "" "" "853.9" "700.8" "770.1" "632.1" "706.6" "779.5" "770.5" "729.9" "693.6" "629.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8919089648667332764" "False" "High" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "0.000" "False" "48.808" "13" "7" "11" "7" "707" "78.5" "4.87" "40.54" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "1.087" "0.919" "1.059" "0.964" "0.872" "1.110" "1.036" "0.925" "0.632" "492.7" "535.5" "452.6" "521.7" "475.2" "429.5" "547.1" "510.6" "455.5" "311.6" "" "" "" "" "" "" "" "" "" "" "444.7" "413.1" "350.1" "351.3" "396.4" "366.6" "464.1" "369.5" "307.3" "311.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741293636862823993" "False" "High" "IsMasterProtein" "Q5T1M5" "FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2" "0.000" "False" "48.791" "8" "9" "13" "9" "1219" "133.5" "5.20" "45.14" "9" "transport" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00254" "23307" "ENSG00000119321" "FKBP15" "hsa:23307; Q05DK8; Q5T1M2; Q5T1M5; Q6DD85; Q9Y4D0" "" "TYROBP causal network in microglia" "1" "0" "0.943" "0.983" "0.989" "0.930" "0.995" "0.899" "0.889" "1.010" "1.749" "593.3" "559.7" "583.3" "586.6" "551.9" "590.1" "533.4" "527.3" "598.9" "1037.4" "" "" "" "" "" "" "" "" "" "" "535.5" "431.7" "451.1" "395.0" "460.4" "503.6" "452.5" "381.6" "404.0" "1037.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221367924290970171" "False" "High" "IsMasterProtein" "Q07812" "Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1" "0.000" "False" "48.768" "33" "5" "13" "5" "192" "21.2" "5.22" "38.49" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "581" "ENSG00000087088" "BAX" "A8K4W1; hsa:581; P55269; Q07812; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6" "Release of apoptotic factors from the mitochondria; Pyroptosis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Activation, translocation and oligomerization of BAX; NTRK3 as a dependence receptor" "miRNA regulation of DNA damage response; TP53 network; Leptin signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; p53 transcriptional gene network; Pleural mesothelioma; Complement system in neuronal development and plasticity; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; IL-26 signaling pathways; HDAC6 interactions in the central nervous system; DNA damage response; DNA damage response (only ATM dependent)" "48" "0" "1.096" "0.835" "1.040" "1.034" "0.819" "1.030" "0.992" "0.851" "0.755" "343.5" "376.5" "286.8" "357.3" "355.4" "281.4" "353.8" "340.7" "292.2" "259.2" "" "" "" "" "" "" "" "" "" "" "310.1" "290.4" "221.9" "240.6" "296.5" "240.2" "300.1" "246.5" "197.1" "259.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4934809763916306973" "False" "High" "IsMasterProtein" "Q6ZS81" "WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3" "0.000" "False" "48.765" "5" "12" "15" "12" "3184" "353.4" "6.32" "43.43" "12" "other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf00400, Pf02138" "57705" "ENSG00000128815" "WDFY4" "B9ZVP2; hsa:57705; Q6ZS81; Q86WZ4; Q8N4A3; Q8TEN7; Q96BE1; Q9H7H8; Q9HCG5" "" "10q11.21q11.23 copy number variation syndrome" "1" "0" "1.076" "0.882" "1.106" "1.020" "0.819" "0.880" "0.844" "0.916" "2.362" "114.4" "123.0" "100.8" "126.5" "116.6" "93.7" "100.6" "96.5" "104.7" "270.1" "" "" "" "" "" "" "" "" "" "" "103.2" "94.9" "78.0" "85.2" "97.3" "79.9" "85.3" "69.8" "70.6" "270.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8008274239603490952" "False" "High" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "0.000" "False" "48.643" "22" "7" "25" "5" "378" "39.6" "9.01" "74.53" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "" "2" "0" "1.112" "1.650" "1.154" "1.080" "1.726" "1.053" "0.945" "1.797" "2.345" "554.6" "616.8" "915.3" "639.9" "599.1" "957.6" "584.0" "524.1" "996.5" "1300.7" "" "" "" "" "" "" "" "" "" "" "500.7" "475.8" "707.9" "430.9" "499.7" "817.3" "495.4" "379.3" "672.1" "1300.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7585773354798248656" "False" "High" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "0.000" "False" "48.643" "31" "5" "12" "5" "199" "21.5" "5.24" "45.99" "5" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "1.063" "0.830" "1.012" "1.057" "0.893" "1.049" "1.136" "0.893" "0.658" "517.5" "550.0" "429.2" "523.9" "546.7" "462.1" "542.6" "587.6" "462.2" "340.7" "" "" "" "" "" "" "" "" "" "" "467.1" "424.2" "332.0" "352.8" "456.1" "394.4" "460.3" "425.2" "311.8" "340.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028893805167112372" "False" "High" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "0.000" "False" "48.629" "24" "11" "16" "10" "444" "49.3" "7.23" "48.75" "11" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "1" "1.040" "0.798" "1.016" "1.038" "0.823" "1.065" "1.065" "0.830" "0.856" "881.9" "916.8" "704.1" "896.0" "915.1" "725.6" "939.0" "939.3" "731.8" "755.2" "" "" "" "" "" "" "" "" "" "" "796.1" "707.2" "544.5" "603.4" "763.4" "619.3" "796.5" "679.7" "493.6" "755.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7263541365096533312" "False" "High" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "0.000" "False" "48.613" "11" "10" "20" "10" "895" "100.2" "5.67" "71.80" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "0.984" "1.179" "1.210" "0.962" "1.147" "1.035" "1.007" "1.116" "0.917" "1929.4" "1899.2" "2275.1" "2335.5" "1856.7" "2212.5" "1997.6" "1943.1" "2153.1" "1769.0" "" "" "" "" "" "" "" "" "" "" "1741.6" "1465.0" "1759.6" "1572.7" "1548.8" "1888.4" "1694.5" "1406.2" "1452.2" "1769.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1403066018753267541" "False" "High" "IsMasterProtein" "Q96RU3" "Formin-binding protein 1 OS=Homo sapiens OX=9606 GN=FNBP1 PE=1 SV=2" "0.000" "False" "48.497" "19" "10" "15" "10" "617" "71.3" "5.72" "50.21" "10" "transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "23048" "ENSG00000187239" "FNBP1" "B7ZL12; E9PGQ4; hsa:23048; O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q96RU3; Q9H8H8; Q9NWD1" "Clathrin-mediated endocytosis; RND2 GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "" "5" "0" "1.002" "0.927" "0.900" "0.913" "0.921" "0.901" "0.830" "0.900" "3.091" "954.4" "956.1" "884.8" "859.1" "871.7" "879.3" "859.9" "791.9" "858.6" "2950.0" "" "" "" "" "" "" "" "" "" "" "861.5" "737.5" "684.4" "578.5" "727.2" "750.5" "729.4" "573.1" "579.1" "2950.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5810129024139572187" "False" "High" "IsMasterProtein" "P34931" "Heat shock 70 kDa protein 1-like OS=Homo sapiens OX=9606 GN=HSPA1L PE=1 SV=2" "0.000" "False" "48.420" "13" "7" "28" "2" "641" "70.3" "6.02" "89.95" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3305" "ENSG00000204390; ENSG00000206383; ENSG00000234258; ENSG00000236251" "HSPA1L" "A6NNB0; B0UXW8; hsa:3305; O75634; P34931; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Attenuation phase" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection" "8" "0" "0.968" "0.890" "0.957" "0.855" "1.064" "0.966" "0.873" "0.919" "1.129" "190.1" "184.0" "169.2" "182.0" "162.6" "202.4" "183.6" "166.0" "174.7" "214.7" "" "" "" "" "" "" "" "" "" "" "171.6" "142.0" "130.9" "122.6" "135.6" "172.7" "155.8" "120.2" "117.8" "214.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428916693947129614" "False" "High" "IsMasterProtein" "Q92556" "Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2" "0.000" "False" "48.407" "18" "15" "20" "15" "727" "83.8" "6.28" "50.18" "15" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf04727, Pf11841, Pf16457" "9844" "ENSG00000155849" "ELMO1" "A4D1X6; hsa:9844; Q29R79; Q6ZTJ0; Q92556; Q96PB0; Q9H0I1" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction" "Chemokine signaling pathway; CCL18 signaling pathway" "7" "0" "0.989" "1.002" "0.937" "1.005" "0.942" "0.992" "0.962" "1.010" "1.829" "1154.6" "1142.3" "1157.2" "1082.1" "1160.0" "1087.9" "1145.8" "1110.7" "1165.6" "2111.9" "" "" "" "" "" "" "" "" "" "" "1042.2" "881.1" "895.0" "728.7" "967.7" "928.6" "972.0" "803.8" "786.2" "2111.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951583387108982266" "False" "High" "IsMasterProtein" "P11171" "Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4" "0.000" "False" "48.307" "11" "9" "11" "9" "864" "97.0" "5.58" "35.74" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2035" "ENSG00000159023" "EPB41" "B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579" "Neurexins and neuroligins" "VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway" "4" "0" "0.974" "0.959" "1.041" "1.098" "1.049" "1.017" "0.965" "1.013" "0.956" "586.0" "570.9" "562.0" "610.1" "643.4" "615.0" "595.9" "565.5" "593.6" "560.4" "" "" "" "" "" "" "" "" "" "" "529.0" "440.3" "434.6" "410.8" "536.7" "524.9" "505.5" "409.2" "400.4" "560.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7186431258293956911" "False" "High" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "0.000" "False" "48.293" "43" "6" "18" "6" "148" "17.2" "9.60" "49.91" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "" "2" "0" "0.977" "1.067" "0.906" "0.991" "1.050" "0.879" "1.029" "1.052" "0.542" "1316.1" "1286.5" "1404.7" "1192.4" "1304.2" "1382.5" "1156.9" "1354.0" "1385.0" "713.0" "" "" "" "" "" "" "" "" "" "" "1188.0" "992.3" "1086.4" "803.0" "1087.9" "1180.0" "981.4" "979.9" "934.2" "713.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009427819375188157" "False" "High" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "0.000" "False" "48.242" "25" "9" "17" "9" "389" "44.1" "7.49" "54.85" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "1.018" "0.770" "0.947" "1.035" "0.791" "0.976" "1.013" "0.765" "0.771" "1890.4" "1925.1" "1455.4" "1789.7" "1956.4" "1495.0" "1845.3" "1915.3" "1446.7" "1456.9" "" "" "" "" "" "" "" "" "" "" "1706.4" "1484.9" "1125.7" "1205.2" "1632.0" "1276.0" "1565.3" "1386.1" "975.8" "1456.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7367615421387894087" "False" "High" "IsMasterProtein" "Q9Y5X3" "Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1" "0.000" "False" "48.238" "24" "9" "13" "8" "404" "46.8" "6.76" "47.39" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "27131" "ENSG00000089006" "SNX5" "B7ZKN3; D3DW26; hsa:27131; Q52LC4; Q7KZN0; Q9BWP0; Q9Y5X3" "Golgi Associated Vesicle Biogenesis" "" "1" "1" "0.987" "0.917" "0.956" "0.916" "0.913" "0.978" "0.906" "0.898" "1.217" "1539.5" "1519.6" "1412.3" "1471.4" "1409.6" "1405.5" "1506.1" "1394.4" "1382.1" "1874.0" "" "" "" "" "" "" "" "" "" "" "1389.6" "1172.1" "1092.3" "990.8" "1175.8" "1199.6" "1277.6" "1009.2" "932.2" "1874.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588161142439279914" "False" "High" "IsMasterProtein" "Q96RG2" "PAS domain-containing serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=PASK PE=1 SV=3" "0.000" "False" "48.230" "8" "8" "13" "8" "1323" "142.8" "4.86" "44.41" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13426" "23178" "ENSG00000115687" "PASK" "G5E9F1; hsa:23178; Q05BE4; Q68DY3; Q6GSJ5; Q86XH6; Q96RG2; Q99763; Q9UFR7" "" "2q37 copy number variation syndrome" "1" "0" "0.990" "0.772" "1.099" "0.930" "0.903" "0.976" "0.934" "0.854" "1.048" "214.1" "212.0" "165.3" "235.2" "199.2" "193.3" "208.9" "199.9" "182.7" "224.3" "" "" "" "" "" "" "" "" "" "" "193.2" "163.5" "127.8" "158.4" "166.1" "164.9" "177.2" "144.6" "123.3" "224.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980650416735823729" "False" "High" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "0.000" "False" "48.186" "24" "9" "16" "9" "332" "37.5" "7.87" "56.58" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "1.015" "0.878" "0.992" "0.882" "0.881" "1.005" "1.044" "0.800" "0.755" "1687.4" "1712.7" "1480.9" "1673.1" "1488.0" "1485.7" "1696.3" "1761.1" "1350.7" "1274.2" "" "" "" "" "" "" "" "" "" "" "1523.1" "1321.0" "1145.4" "1126.7" "1241.2" "1268.1" "1438.9" "1274.5" "911.0" "1274.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6734575471453550747" "False" "High" "IsMasterProtein" "Q6FI81" "Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2" "0.000" "False" "48.073" "26" "8" "14" "8" "312" "33.6" "5.62" "46.42" "8" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05093, Pf20922" "57019" "ENSG00000005194" "CIAPIN1" "A8K8B6; hsa:57019; O75206; O75207; Q6FI81; Q9H0W1; Q9P1L7" "Cytosolic iron-sulfur cluster assembly" "" "1" "0" "0.975" "0.964" "1.016" "0.956" "0.978" "0.965" "1.027" "0.944" "1.053" "1271.2" "1239.7" "1225.9" "1291.5" "1215.6" "1243.1" "1226.4" "1305.9" "1200.1" "1338.7" "" "" "" "" "" "" "" "" "" "" "1147.5" "956.2" "948.2" "869.7" "1014.0" "1061.0" "1040.4" "945.0" "809.5" "1338.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1887782222287180929" "False" "High" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "0.000" "False" "48.006" "17" "9" "17" "8" "474" "53.2" "7.08" "54.01" "9" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "1.017" "1.120" "0.892" "0.956" "1.040" "0.963" "0.966" "1.034" "0.857" "846.4" "860.7" "948.1" "755.1" "808.9" "880.3" "815.4" "817.5" "874.9" "725.2" "" "" "" "" "" "" "" "" "" "" "764.0" "663.9" "733.3" "508.5" "674.7" "751.4" "691.7" "591.6" "590.1" "725.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6575601821171362980" "False" "High" "IsMasterProtein" "P39019" "Small ribosomal subunit protein eS19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "0.000" "False" "47.994" "46" "7" "29" "7" "145" "16.1" "10.32" "86.86" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Complement system; Cytoplasmic ribosomal proteins" "20" "0" "0.970" "0.985" "1.044" "1.048" "0.980" "0.983" "0.983" "0.991" "0.579" "1162.9" "1127.5" "1145.5" "1214.3" "1218.9" "1139.9" "1143.0" "1143.5" "1152.4" "673.0" "" "" "" "" "" "" "" "" "" "" "1049.7" "869.7" "886.0" "817.7" "1016.7" "972.9" "969.6" "827.5" "777.3" "673.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4459716120349710015" "False" "High" "IsMasterProtein" "O14545" "TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1" "0.000" "False" "47.989" "21" "11" "16" "11" "582" "64.8" "5.29" "45.08" "11" "other biological processes" "mitochondrion" "other molecular function" "Pf21366" "10906" "ENSG00000135148" "TRAFD1" "A8K5L6; B4DI89; hsa:10906; O14545" "" "" "0" "0" "0.991" "1.343" "0.996" "1.140" "1.244" "1.213" "1.367" "1.275" "1.061" "844.2" "836.9" "1133.7" "840.5" "962.2" "1050.0" "1024.0" "1154.2" "1076.2" "895.3" "" "" "" "" "" "" "" "" "" "" "762.0" "645.6" "876.9" "566.0" "802.6" "896.2" "868.6" "835.3" "725.9" "895.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106198041571123129" "False" "High" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "0.000" "False" "47.981" "22" "10" "18" "10" "504" "55.1" "6.61" "50.84" "10" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "Q9UMS4" "mRNA Splicing - Major Pathway; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of TC-NER Pre-Incision Complex" "" "5" "0" "0.975" "0.986" "1.070" "1.033" "1.004" "0.993" "1.004" "0.942" "0.594" "1016.4" "991.2" "1002.0" "1087.5" "1049.5" "1020.5" "1009.3" "1020.5" "957.3" "603.7" "" "" "" "" "" "" "" "" "" "" "917.4" "764.5" "775.0" "732.3" "875.4" "871.0" "856.2" "738.6" "645.7" "603.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577661902964436810" "False" "High" "IsMasterProtein" "Q3LXA3" "Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2" "0.000" "False" "47.971" "19" "10" "14" "10" "575" "58.9" "7.49" "46.11" "10" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf02733, Pf02734" "26007" "ENSG00000149476" "TKFC" "hsa:26007; Q2L9C1; Q3LXA3; Q53EQ9; Q9BVA7; Q9H895" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; Fructose catabolism" "Novel intracellular components of RIG-I-like receptor pathway" "5" "0" "0.999" "0.899" "0.982" "0.961" "0.927" "1.041" "0.956" "0.902" "0.819" "692.7" "692.0" "622.9" "680.1" "665.7" "642.5" "721.4" "662.0" "624.9" "567.5" "" "" "" "" "" "" "" "" "" "" "625.3" "533.7" "481.7" "458.0" "555.3" "548.4" "612.0" "479.1" "421.5" "567.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792306396308701389" "False" "High" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "0.000" "False" "47.953" "12" "12" "14" "11" "955" "108.6" "10.15" "43.06" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "Interactome of polycomb repressive complex 2 (PRC2)" "3" "1" "1.029" "1.295" "1.026" "1.114" "1.180" "1.040" "0.997" "1.287" "1.032" "873.1" "898.1" "1130.9" "896.2" "972.3" "1030.2" "907.9" "870.5" "1123.3" "901.3" "" "" "" "" "" "" "" "" "" "" "788.1" "692.8" "874.7" "603.5" "811.1" "879.3" "770.1" "630.0" "757.7" "901.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197939441703168183" "False" "High" "IsMasterProtein" "Cont_P12763" "Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2" "0.000" "True" "47.863" "26" "8" "17" "8" "359" "38.4" "5.50" "58.83" "8" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00031" "280988" "ENSBTAG00000000522" "AHSG" "A6QLF7; B0JYN6; bta:280988; P12763" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "4" "0" "1.040" "0.993" "1.184" "0.922" "1.374" "0.888" "0.937" "1.614" "0.800" "488.0" "507.5" "484.8" "577.9" "450.0" "670.6" "433.1" "457.1" "787.6" "390.7" "" "" "" "" "" "" "" "" "" "" "440.5" "391.5" "375.0" "389.2" "375.3" "572.4" "367.4" "330.8" "531.3" "390.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6598258105920115633" "False" "High" "IsMasterProtein" "Q5TDH0" "Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1" "0.000" "False" "47.834" "24" "7" "12" "7" "399" "44.5" "5.05" "38.67" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf09668" "84301" "ENSG00000197312" "DDI2" "A8KAE1; hsa:84301; Q5TDH0; Q7RTZ0; Q9BRT1" "" "" "0" "0" "0.969" "0.862" "0.994" "0.978" "0.873" "0.997" "1.005" "0.847" "0.813" "535.3" "518.5" "461.4" "532.3" "523.7" "467.4" "533.9" "537.8" "453.4" "435.3" "" "" "" "" "" "" "" "" "" "" "483.2" "399.9" "356.9" "358.5" "436.8" "399.0" "452.9" "389.2" "305.8" "435.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1811724669038293962" "False" "High" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "0.000" "False" "47.832" "14" "12" "15" "12" "751" "83.4" "7.01" "46.66" "12" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "Mitochondrial translation elongation" "" "1" "0" "0.953" "0.874" "0.934" "0.993" "0.855" "0.965" "0.911" "0.891" "1.579" "1126.0" "1072.5" "983.8" "1051.3" "1117.8" "962.6" "1086.7" "1025.5" "1002.7" "1778.1" "" "" "" "" "" "" "" "" "" "" "1016.4" "827.3" "760.9" "707.9" "932.4" "821.6" "921.8" "742.1" "676.3" "1778.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5379927886480691395" "False" "High" "IsMasterProtein" "O95456" "Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1" "0.000" "False" "47.827" "26" "8" "19" "8" "288" "32.8" "7.17" "56.22" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf16094" "8624" "ENSG00000183527" "PSMG1" "B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713" "" "" "0" "0" "1.021" "0.910" "1.112" "0.973" "0.926" "1.074" "0.970" "0.987" "0.737" "611.1" "623.7" "556.3" "679.6" "594.5" "566.1" "656.2" "592.7" "603.3" "450.6" "" "" "" "" "" "" "" "" "" "" "551.6" "481.1" "430.3" "457.7" "495.9" "483.1" "556.6" "428.9" "406.9" "450.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570733689934674061" "False" "High" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "0.000" "False" "47.734" "34" "7" "12" "6" "215" "23.9" "6.21" "41.03" "7" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "7" "0" "1.007" "1.170" "1.005" "1.000" "1.166" "0.981" "1.024" "1.154" "0.655" "1227.9" "1236.9" "1436.4" "1234.0" "1228.0" "1431.2" "1203.9" "1257.4" "1416.8" "804.0" "" "" "" "" "" "" "" "" "" "" "1108.4" "954.1" "1110.9" "830.9" "1024.3" "1221.5" "1021.3" "910.0" "955.6" "804.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4107495286689168051" "False" "High" "IsMasterProtein" "P42566" "Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2" "0.000" "False" "47.717" "14" "10" "11" "10" "896" "98.6" "4.64" "36.08" "10" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "" "2060" "ENSG00000085832" "EPS15" "B2R8J7; D3DPJ2; hsa:2060; P42566; Q5SRH4" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; EGF/EGFR signaling pathway" "8" "0" "1.013" "0.905" "0.983" "0.893" "0.895" "0.982" "0.888" "0.876" "1.386" "413.5" "419.0" "374.0" "406.4" "369.4" "370.1" "405.8" "367.3" "362.0" "573.1" "" "" "" "" "" "" "" "" "" "" "373.2" "323.2" "289.2" "273.7" "308.1" "315.9" "344.2" "265.8" "244.2" "573.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002487047349753336" "False" "High" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "0.000" "False" "47.701" "48" "9" "50" "1" "152" "17.3" "8.41" "138.38" "9" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Neutrophil degranulation; Azathioprine ADME; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME" "Pyrimidine metabolism" "5" "7" "0.947" "1.024" "1.070" "0.983" "1.071" "0.992" "0.991" "1.129" "0.702" "2650.4" "2511.0" "2714.4" "2837.0" "2604.7" "2839.4" "2628.8" "2627.1" "2991.7" "1861.2" "" "" "" "" "" "" "" "" "" "" "2392.4" "1936.9" "2099.4" "1910.4" "2172.8" "2423.4" "2230.0" "1901.2" "2017.8" "1861.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7164252361216930989" "False" "High" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "0.000" "False" "47.679" "26" "6" "17" "6" "260" "30.5" "5.21" "55.82" "6" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Pyrimidine salvage; Purine salvage" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "4" "0" "0.986" "0.916" "0.955" "0.967" "0.913" "1.023" "1.013" "0.887" "0.746" "595.0" "586.8" "545.1" "568.4" "575.7" "543.1" "608.8" "602.5" "527.5" "444.0" "" "" "" "" "" "" "" "" "" "" "537.1" "452.6" "421.6" "382.8" "480.2" "463.5" "516.4" "436.1" "355.8" "444.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625268949045148761" "False" "High" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "0.000" "False" "47.637" "12" "10" "11" "10" "923" "102.8" "5.22" "35.47" "10" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "Regulation of HSF1-mediated heat shock response" "TAR syndrome" "2" "0" "0.899" "1.376" "1.139" "0.979" "1.295" "1.015" "0.575" "1.362" "6.491" "236.4" "212.5" "325.3" "269.2" "231.5" "306.3" "240.1" "135.9" "322.1" "1534.8" "" "" "" "" "" "" "" "" "" "" "213.4" "163.9" "251.6" "181.3" "193.1" "261.4" "203.6" "98.4" "217.3" "1534.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6733467377289635687" "False" "High" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "0.000" "False" "47.522" "25" "11" "21" "3" "428" "49.0" "5.67" "59.60" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle" "" "5" "0" "0.977" "0.870" "1.063" "0.984" "0.845" "0.946" "0.903" "0.970" "0.922" "155.2" "151.7" "135.1" "164.9" "152.7" "131.2" "146.9" "140.1" "150.5" "143.1" "" "" "" "" "" "" "" "" "" "" "140.1" "117.0" "104.5" "111.1" "127.4" "112.0" "124.6" "101.4" "101.5" "143.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2851468461982241185" "False" "High" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "0.000" "False" "47.491" "26" "5" "22" "5" "198" "21.7" "5.59" "62.19" "5" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13499, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "" "5" "0" "1.024" "1.155" "1.221" "1.071" "1.160" "1.101" "1.055" "1.188" "0.792" "1141.5" "1169.4" "1317.9" "1394.0" "1222.7" "1324.2" "1256.9" "1204.2" "1355.9" "904.4" "" "" "" "" "" "" "" "" "" "" "1030.4" "902.0" "1019.3" "938.7" "1019.9" "1130.2" "1066.2" "871.4" "914.6" "904.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5898955459380036323" "False" "High" "IsMasterProtein" "Q05048" "Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1" "0.000" "False" "47.422" "22" "9" "14" "9" "431" "48.3" "6.58" "43.24" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00400, Pf16699" "1477" "ENSG00000101138" "CSTF1" "hsa:1477; Q05048; Q5QPD8" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "1.041" "0.923" "1.047" "0.991" "0.941" "0.971" "1.013" "0.958" "0.792" "548.3" "570.9" "506.0" "573.9" "543.2" "516.1" "532.6" "555.4" "525.1" "434.0" "" "" "" "" "" "" "" "" "" "" "494.9" "440.3" "391.4" "386.5" "453.1" "440.5" "451.8" "402.0" "354.2" "434.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7915311945115274700" "False" "High" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "0.000" "False" "47.414" "49" "7" "14" "7" "129" "14.6" "8.88" "44.58" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "0.912" "0.930" "0.967" "0.869" "0.920" "0.900" "0.893" "0.909" "0.633" "558.1" "509.0" "519.1" "539.6" "484.9" "513.2" "502.4" "498.2" "507.3" "353.2" "" "" "" "" "" "" "" "" "" "" "503.8" "392.6" "401.5" "363.4" "404.5" "438.1" "426.2" "360.5" "342.2" "353.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3142486401368971215" "False" "High" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "0.000" "False" "47.393" "14" "8" "11" "8" "729" "79.5" "5.22" "39.21" "8" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08477" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "0.990" "0.921" "1.075" "0.988" "0.941" "0.986" "0.959" "0.959" "0.741" "793.4" "785.4" "730.6" "852.6" "783.5" "746.4" "782.4" "760.8" "760.8" "588.1" "" "" "" "" "" "" "" "" "" "" "716.2" "605.8" "565.1" "574.1" "653.6" "637.1" "663.7" "550.6" "513.2" "588.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "714954485545523239" "False" "High" "IsMasterProtein" "P27986" "Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2" "0.000" "False" "47.346" "16" "12" "13" "11" "724" "83.5" "6.16" "39.61" "12" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5295" "ENSG00000145675" "PIK3R1" "B3KT19; D3DWA0; E7EX19; hsa:5295; P27986; Q15747; Q4VBZ7; Q53EM6; Q8IXA2; Q8N1C5" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RAF/MAP kinase cascade; PI3K Cascade; PI-3K cascade:FGFR4; Signaling by FGFR4 in disease; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOC GTPase cycle; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; G alpha (q) signalling events; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "154" "0" "0.989" "0.770" "0.911" "0.972" "0.790" "0.971" "0.958" "0.841" "1.116" "792.0" "783.6" "610.1" "721.7" "770.1" "625.9" "769.1" "758.7" "666.0" "884.2" "" "" "" "" "" "" "" "" "" "" "714.9" "604.4" "471.9" "486.0" "642.4" "534.2" "652.4" "549.1" "449.2" "884.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "170444545631699205" "False" "High" "IsMasterProtein" "Q9Y4E1" "WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=5" "0.000" "False" "47.233" "8" "7" "10" "7" "1341" "147.1" "4.81" "36.80" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "253725" "ENSG00000172661" "WASHC2C" "A0A096LPC5; B4DZQ6; B9EK53; F5H0J6; F5H871; hsa:253725; Q5SQU4; Q5SQU5; Q7L521; Q9UG79; Q9Y4E1" "" "" "0" "0" "1.048" "1.172" "1.139" "1.011" "1.049" "0.984" "1.010" "1.085" "1.212" "513.3" "538.0" "601.5" "584.7" "519.0" "538.6" "505.0" "518.4" "557.0" "622.2" "" "" "" "" "" "" "" "" "" "" "463.3" "415.0" "465.2" "393.7" "433.0" "459.7" "428.4" "375.2" "375.7" "622.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642544614061212331" "False" "High" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "0.000" "False" "47.220" "28" "12" "21" "12" "391" "42.3" "10.05" "59.52" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "mRNA Splicing - Major Pathway; RND2 GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "8" "0" "1.029" "1.551" "1.097" "1.268" "1.674" "1.019" "1.024" "1.585" "1.852" "583.8" "600.8" "905.4" "640.2" "739.9" "977.3" "594.6" "597.8" "925.2" "1081.3" "" "" "" "" "" "" "" "" "" "" "527.0" "463.4" "700.3" "431.1" "617.2" "834.2" "504.4" "432.6" "624.0" "1081.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-536665306058471520" "False" "High" "IsMasterProtein" "Q07020" "Large ribosomal subunit protein eL18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "0.000" "False" "47.132" "35" "6" "18" "6" "188" "21.6" "11.72" "62.00" "6" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "0.839" "0.991" "0.958" "0.936" "0.909" "0.945" "0.940" "0.912" "0.344" "882.2" "739.9" "874.5" "845.1" "826.0" "802.1" "834.1" "829.4" "805.0" "303.8" "" "" "" "" "" "" "" "" "" "" "796.3" "570.7" "676.4" "569.1" "689.0" "684.6" "707.6" "600.2" "542.9" "303.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1852571755298916304" "False" "High" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "0.000" "False" "47.049" "21" "9" "12" "9" "468" "50.1" "7.06" "41.07" "9" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Early Events; snRNP Assembly; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "1.001" "0.944" "0.979" "0.988" "0.953" "0.932" "1.021" "0.924" "0.796" "874.6" "875.2" "825.9" "856.6" "863.9" "833.2" "814.8" "892.9" "807.8" "696.1" "" "" "" "" "" "" "" "" "" "" "789.5" "675.1" "638.8" "576.9" "720.6" "711.2" "691.2" "646.2" "544.9" "696.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135385361793162553" "False" "High" "IsMasterProtein" "Q9BQA1" "Methylosome protein WDR77 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "0.000" "False" "46.954" "27" "6" "17" "6" "342" "36.7" "5.17" "54.43" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "snRNP Assembly; RMTs methylate histone arginines" "" "2" "0" "0.949" "0.801" "0.976" "0.916" "0.850" "0.962" "0.984" "0.820" "0.628" "428.8" "407.1" "343.5" "418.3" "392.8" "364.5" "412.3" "422.1" "351.6" "269.4" "" "" "" "" "" "" "" "" "" "" "387.1" "314.0" "265.7" "281.7" "327.6" "311.1" "349.8" "305.5" "237.1" "269.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518810540954697302" "False" "High" "IsMasterProtein" "Q8TAT6" "Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3" "0.000" "False" "46.906" "19" "11" "14" "11" "608" "68.1" "6.38" "47.26" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05020, Pf05021, Pf11543" "55666" "ENSG00000182446" "NPLOC4" "hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229" "KEAP1-NFE2L2 pathway; Neddylation; Translesion Synthesis by POLH" "" "3" "0" "1.021" "1.035" "0.988" "1.042" "1.030" "1.058" "0.990" "1.010" "0.915" "942.7" "962.9" "975.7" "931.4" "982.7" "970.9" "997.1" "933.5" "952.0" "862.2" "" "" "" "" "" "" "" "" "" "" "850.9" "742.8" "754.7" "627.2" "819.8" "828.7" "845.8" "675.6" "642.1" "862.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5749593247568362596" "False" "High" "IsMasterProtein" "Q9NYV4" "Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2" "0.000" "False" "46.793" "6" "8" "11" "7" "1490" "164.1" "9.44" "37.90" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "51755" "ENSG00000167258" "CDK12" "A7E2B2; B4DYX4; B9EIQ6; hsa:51755; O94978; Q9NYV4" "TP53 Regulates Transcription of DNA Repair Genes" "17q12 copy number variation syndrome" "2" "1" "1.016" "0.826" "0.951" "1.037" "0.872" "0.933" "1.007" "0.912" "0.874" "480.3" "488.2" "396.8" "456.9" "498.3" "418.8" "448.0" "483.8" "437.9" "419.9" "" "" "" "" "" "" "" "" "" "" "433.5" "376.5" "306.9" "307.7" "415.6" "357.5" "380.1" "350.1" "295.4" "419.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1351774447437735542" "False" "High" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "0.000" "False" "46.702" "17" "10" "14" "9" "623" "69.9" "5.67" "41.11" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "1" "0.955" "1.006" "1.032" "0.952" "0.999" "1.044" "0.966" "1.030" "0.999" "564.0" "538.4" "567.5" "582.2" "536.9" "563.5" "588.9" "544.9" "581.2" "563.2" "" "" "" "" "" "" "" "" "" "" "509.1" "415.3" "439.0" "392.0" "447.8" "480.9" "499.5" "394.4" "392.0" "563.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3464884523288308990" "False" "High" "IsMasterProtein" "Q12972" "Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2" "0.000" "False" "46.649" "11" "3" "6" "3" "351" "38.5" "7.37" "28.29" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00498" "5511" "ENSG00000117751" "PPP1R8" "hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.057" "1.044" "1.125" "0.910" "0.873" "1.016" "1.008" "1.023" "1.048" "215.9" "228.2" "225.5" "242.9" "196.4" "188.5" "219.4" "217.7" "220.8" "226.3" "" "" "" "" "" "" "" "" "" "" "194.9" "176.0" "174.4" "163.6" "163.8" "160.9" "186.1" "157.5" "149.0" "226.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8973265240341480372" "False" "High" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "0.000" "False" "46.536" "20" "9" "14" "9" "517" "57.4" "6.76" "48.09" "9" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Purine ribonucleoside monophosphate biosynthesis" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "3" "0" "0.802" "0.920" "0.833" "0.764" "0.993" "0.800" "0.906" "0.884" "0.726" "465.0" "372.8" "427.9" "387.2" "355.1" "461.6" "372.0" "421.1" "411.2" "337.5" "" "" "" "" "" "" "" "" "" "" "419.8" "287.6" "331.0" "260.8" "296.2" "394.0" "315.6" "304.8" "277.4" "337.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2297110738803864325" "False" "High" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "0.000" "False" "46.528" "22" "4" "22" "4" "214" "22.1" "8.70" "58.82" "4" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "" "Selenium micronutrient network" "1" "0" "1.016" "0.856" "0.946" "0.975" "0.882" "0.993" "0.985" "0.833" "0.637" "861.0" "874.6" "737.0" "814.9" "839.3" "759.4" "854.8" "848.5" "717.3" "548.8" "" "" "" "" "" "" "" "" "" "" "777.2" "674.6" "570.0" "548.7" "700.1" "648.1" "725.1" "614.1" "483.8" "548.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5310524526174993710" "False" "High" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "0.000" "False" "46.403" "12" "9" "14" "5" "745" "82.8" "7.37" "41.73" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "3" "0.990" "0.842" "0.947" "0.974" "0.881" "0.985" "1.055" "0.822" "0.864" "344.5" "341.2" "290.0" "326.4" "335.7" "303.6" "339.3" "363.4" "283.2" "297.8" "" "" "" "" "" "" "" "" "" "" "311.0" "263.1" "224.3" "219.8" "280.0" "259.1" "287.8" "263.0" "191.0" "297.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534228375388649933" "False" "High" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "0.000" "False" "46.401" "6" "11" "14" "11" "1817" "197.5" "6.40" "44.56" "11" "cell organization and biogenesis;protein metabolism;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110, Pf21240" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "1" "0" "1.027" "0.880" "0.974" "1.041" "0.895" "1.000" "1.047" "0.862" "1.098" "930.9" "955.7" "818.8" "906.9" "968.8" "833.2" "930.6" "975.1" "802.3" "1022.2" "" "" "" "" "" "" "" "" "" "" "840.3" "737.1" "633.3" "610.7" "808.1" "711.2" "789.4" "705.7" "541.1" "1022.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939366548436887845" "False" "High" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "0.000" "False" "46.257" "28" "11" "17" "11" "403" "47.3" "9.36" "44.54" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "" "3" "0" "0.889" "0.742" "0.900" "0.869" "0.731" "0.943" "0.971" "0.737" "0.745" "461.9" "410.6" "342.6" "415.7" "401.5" "337.6" "435.6" "448.5" "340.3" "344.1" "" "" "" "" "" "" "" "" "" "" "417.0" "316.7" "265.0" "279.9" "334.9" "288.1" "369.5" "324.6" "229.5" "344.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101901840121098087" "False" "High" "IsMasterProtein" "P52788" "Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2" "0.000" "False" "46.250" "20" "7" "18" "7" "366" "41.2" "5.02" "58.20" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf01564, Pf17284, Pf17950" "6611" "ENSG00000102172" "SMS" "A6NHA7; A6NI34; B2R9M0; hsa:6611; O00544; P52788; Q9UQS1" "Metabolism of polyamines" "Methionine de novo and salvage pathway; Amino acid metabolism" "3" "0" "1.032" "1.107" "1.076" "0.998" "1.128" "1.065" "0.984" "1.076" "0.729" "683.7" "705.6" "756.6" "735.6" "682.1" "771.0" "728.0" "672.9" "736.0" "498.5" "" "" "" "" "" "" "" "" "" "" "617.2" "544.2" "585.2" "495.3" "569.0" "658.1" "617.6" "486.9" "496.4" "498.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051331415144919391" "False" "High" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "0.000" "False" "46.234" "18" "9" "17" "9" "494" "53.8" "5.87" "50.24" "9" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "Carnitine synthesis" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "4" "0" "1.036" "1.063" "1.004" "1.009" "1.067" "1.010" "0.972" "1.032" "0.625" "978.6" "1013.8" "1039.9" "982.8" "987.9" "1044.4" "988.8" "951.1" "1009.6" "611.8" "" "" "" "" "" "" "" "" "" "" "883.4" "782.0" "804.3" "661.8" "824.1" "891.4" "838.8" "688.3" "681.0" "611.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2637590011477773491" "False" "High" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "0.000" "False" "46.217" "16" "12" "13" "12" "744" "82.5" "6.95" "42.83" "12" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; P46459; Q8N6D7; Q9UKZ2" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Vasopressin-regulated water reabsorption" "9" "0" "1.019" "0.849" "1.048" "1.129" "0.930" "1.207" "1.019" "0.957" "0.811" "1165.3" "1187.1" "989.2" "1220.8" "1315.6" "1083.2" "1406.8" "1187.9" "1115.5" "945.1" "" "" "" "" "" "" "" "" "" "" "1051.9" "915.6" "765.1" "822.1" "1097.5" "924.5" "1193.4" "859.7" "752.4" "945.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328397515797573102" "False" "High" "IsMasterProtein" "A6NDG6" "Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1" "0.000" "False" "46.138" "24" "6" "13" "6" "321" "34.0" "6.14" "42.61" "6" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13242, Pf13344" "283871" "ENSG00000184207" "PGP" "A6NDG6; hsa:283871" "Glycolysis" "" "1" "0" "1.017" "1.036" "1.014" "0.975" "0.976" "1.027" "1.043" "1.022" "0.718" "704.1" "715.9" "729.3" "713.9" "686.8" "687.5" "723.0" "734.3" "719.7" "505.6" "" "" "" "" "" "" "" "" "" "" "635.6" "552.2" "564.0" "480.8" "572.9" "586.8" "613.3" "531.4" "485.4" "505.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654081652263858131" "False" "High" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "0.000" "False" "46.049" "32" "8" "14" "8" "390" "43.0" "5.26" "34.17" "8" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07528, Pf20965" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "Neutrophil degranulation; PKR-mediated signaling" "B cell receptor signaling pathway" "3" "0" "1.048" "1.177" "1.091" "0.925" "1.313" "1.076" "0.979" "1.277" "0.995" "371.4" "389.1" "437.2" "405.3" "343.5" "487.7" "399.8" "363.4" "474.4" "369.4" "" "" "" "" "" "" "" "" "" "" "335.2" "300.1" "338.1" "272.9" "286.5" "416.3" "339.1" "263.0" "320.0" "369.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980500697727064305" "False" "High" "IsMasterProtein" "O43815" "Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4" "0.000" "False" "46.021" "17" "10" "13" "10" "780" "86.1" "5.27" "43.59" "10" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400, Pf08232" "6801" "ENSG00000115808" "STRN" "hsa:6801; O43815; Q3KP65; Q53TQ8; Q9NP38" "PIP3 activates AKT signaling; Extra-nuclear estrogen signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "MET in type 1 papillary renal cell carcinoma" "8" "0" "1.011" "1.095" "1.049" "0.901" "1.190" "1.142" "1.080" "1.201" "0.953" "292.2" "295.4" "320.0" "306.5" "263.4" "347.8" "333.6" "315.8" "351.0" "278.5" "" "" "" "" "" "" "" "" "" "" "263.8" "227.9" "247.5" "206.4" "219.7" "296.8" "283.0" "228.5" "236.7" "278.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198800325193539681" "False" "High" "IsMasterProtein" "P30050" "Large ribosomal subunit protein uL11 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "0.000" "False" "45.978" "44" "5" "9" "5" "165" "17.8" "9.42" "34.30" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.891" "1.132" "0.955" "0.960" "0.938" "0.944" "0.997" "1.055" "0.348" "636.4" "567.0" "720.2" "608.0" "610.7" "597.1" "601.0" "634.7" "671.3" "221.5" "" "" "" "" "" "" "" "" "" "" "574.4" "437.3" "557.0" "409.4" "509.4" "509.6" "509.8" "459.3" "452.8" "221.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755296670490160775" "False" "High" "IsMasterProtein" "Q96SB3" "Neurabin-2 OS=Homo sapiens OX=9606 GN=PPP1R9B PE=1 SV=3" "0.000" "False" "45.961" "10" "8" "10" "8" "817" "89.3" "4.97" "36.14" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00595, Pf17817" "84687" "ENSG00000108819" "PPP1R9B" "D3DTX6; hsa:84687; Q8TCR9; Q96SB3" "" "" "0" "0" "0.950" "1.018" "1.025" "1.070" "1.010" "1.004" "0.925" "1.178" "1.868" "242.9" "230.7" "247.3" "248.9" "259.9" "245.3" "243.9" "224.8" "286.1" "453.8" "" "" "" "" "" "" "" "" "" "" "219.3" "178.0" "191.3" "167.6" "216.8" "209.4" "206.9" "162.7" "192.9" "453.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459362278607736604" "False" "High" "IsMasterProtein" "Q9HB07" "MYG1 exonuclease OS=Homo sapiens OX=9606 GN=MYG1 PE=1 SV=4" "0.000" "False" "45.958" "16" "5" "11" "5" "376" "42.5" "6.84" "33.68" "5" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03690" "60314" "ENSG00000139637; ENSG00000291835" "MYG1" "hsa:60314; Q86UA3; Q9HB07" "" "" "0" "0" "1.046" "0.992" "1.034" "1.049" "1.163" "1.006" "0.966" "1.086" "1.098" "371.3" "388.4" "368.3" "383.8" "389.5" "431.9" "373.6" "358.6" "403.3" "407.5" "" "" "" "" "" "" "" "" "" "" "335.1" "299.6" "284.9" "258.4" "324.9" "368.6" "316.9" "259.5" "272.0" "407.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3944775931209301438" "False" "High" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "0.000" "False" "45.860" "36" "5" "25" "3" "151" "16.9" "4.65" "87.20" "5" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Ciliary landscape" "8" "3" "1.044" "0.925" "0.908" "0.923" "0.807" "0.956" "1.084" "0.894" "0.984" "1527.0" "1594.9" "1413.0" "1386.5" "1408.9" "1233.1" "1460.3" "1655.4" "1365.1" "1502.2" "" "" "" "" "" "" "" "" "" "" "1378.4" "1230.2" "1092.9" "933.7" "1175.3" "1052.4" "1238.8" "1198.0" "920.7" "1502.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5526079506929447963" "False" "High" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "0.000" "False" "45.832" "11" "11" "14" "11" "1153" "130.1" "8.48" "42.33" "11" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "1.021" "0.959" "0.962" "0.931" "0.926" "0.907" "0.928" "0.981" "1.167" "659.8" "673.9" "632.4" "634.4" "614.4" "611.1" "598.4" "612.2" "647.3" "769.8" "" "" "" "" "" "" "" "" "" "" "595.5" "519.8" "489.1" "427.2" "512.5" "521.6" "507.6" "443.0" "436.6" "769.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3035595102958398127" "False" "High" "IsMasterProtein" "P46777" "Large ribosomal subunit protein uL18 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "0.000" "False" "45.813" "24" "8" "26" "8" "297" "34.3" "9.72" "77.05" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.957" "1.309" "0.857" "1.034" "1.171" "1.018" "1.057" "1.190" "0.416" "1315.8" "1259.0" "1722.1" "1127.2" "1360.9" "1541.1" "1339.3" "1391.3" "1565.8" "547.2" "" "" "" "" "" "" "" "" "" "" "1187.8" "971.1" "1331.9" "759.1" "1135.2" "1315.4" "1136.1" "1006.9" "1056.1" "547.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264120083815806641" "False" "High" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "0.000" "False" "45.762" "52" "6" "14" "6" "125" "14.3" "6.04" "45.83" "6" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "0.974" "1.035" "0.843" "0.921" "0.983" "0.995" "1.033" "0.957" "0.694" "956.5" "931.2" "989.8" "806.3" "881.4" "940.7" "952.2" "988.4" "915.3" "663.5" "" "" "" "" "" "" "" "" "" "" "863.4" "718.3" "765.5" "543.0" "735.2" "802.9" "807.7" "715.3" "617.4" "663.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5119731611670534936" "False" "High" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "0.000" "False" "45.705" "10" "12" "13" "12" "1272" "141.3" "5.41" "41.70" "12" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "14" "0" "0.953" "0.951" "1.001" "0.928" "0.894" "0.916" "0.619" "0.853" "4.891" "387.9" "369.5" "368.9" "388.4" "360.0" "346.9" "355.2" "240.1" "330.7" "1897.3" "" "" "" "" "" "" "" "" "" "" "350.1" "285.0" "285.4" "261.6" "300.3" "296.1" "301.3" "173.8" "223.1" "1897.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6930052097087835026" "False" "High" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "0.000" "False" "45.679" "11" "7" "9" "7" "741" "82.5" "5.06" "31.67" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "Condensation of Prometaphase Chromosomes" "2q11.2 copy number variation syndrome" "2" "0" "0.964" "0.745" "0.994" "0.873" "0.901" "0.898" "0.803" "0.868" "3.041" "112.8" "108.8" "84.0" "112.1" "98.4" "101.6" "101.3" "90.7" "97.9" "343.1" "" "" "" "" "" "" "" "" "" "" "101.8" "83.9" "65.0" "75.5" "82.1" "86.7" "85.9" "65.6" "66.1" "343.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591568921065242388" "False" "High" "IsMasterProtein" "Q8NB90" "ATPase family gene 2 protein homolog A OS=Homo sapiens OX=9606 GN=AFG2A PE=1 SV=3" "0.000" "False" "45.553" "12" "10" "15" "9" "893" "97.8" "5.66" "47.45" "10" "developmental processes;other biological processes" "cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf17862" "166378" "ENSG00000145375" "AFG2A" "C9JT97; hsa:166378; Q86XW1; Q8NB90; Q8NI20; Q8TDL7" "" "" "0" "0" "0.986" "0.771" "0.981" "0.901" "0.624" "1.019" "1.025" "0.749" "0.684" "1019.0" "1004.4" "785.4" "999.8" "917.7" "635.7" "1038.7" "1044.6" "762.9" "697.1" "" "" "" "" "" "" "" "" "" "" "919.8" "774.7" "607.4" "673.3" "765.5" "542.6" "881.1" "756.0" "514.6" "697.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737911317243548471" "False" "High" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "0.000" "False" "45.510" "25" "7" "13" "7" "228" "26.2" "6.44" "46.79" "7" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "Small interfering RNA (siRNA) biogenesis" "" "1" "0" "0.961" "1.110" "1.004" "0.905" "1.105" "0.987" "0.942" "0.988" "0.829" "606.2" "582.3" "672.8" "608.5" "548.7" "670.0" "598.5" "571.1" "599.2" "502.5" "" "" "" "" "" "" "" "" "" "" "547.2" "449.1" "520.4" "409.8" "457.7" "571.8" "507.7" "413.3" "404.1" "502.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4915588766185396896" "False" "High" "IsMasterProtein" "Q86U44" "N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2" "0.000" "False" "45.466" "19" "9" "10" "9" "580" "64.4" "6.42" "33.71" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "56339" "ENSG00000165819" "METTL3" "hsa:56339; O14736; Q86U44; Q86V05; Q9HB32" "Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "2" "0" "1.123" "0.976" "1.029" "1.025" "1.096" "1.056" "1.143" "0.950" "0.907" "212.4" "238.4" "207.3" "218.5" "217.8" "232.7" "224.3" "242.6" "201.8" "192.5" "" "" "" "" "" "" "" "" "" "" "191.7" "183.9" "160.3" "147.1" "181.7" "198.6" "190.3" "175.6" "136.1" "192.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636638520442762569" "False" "High" "IsMasterProtein" "P54725" "UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1" "0.000" "False" "45.444" "22" "8" "21" "6" "363" "39.6" "4.58" "66.24" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5886" "ENSG00000179262" "RAD23A" "hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "6" "0" "0.980" "1.069" "1.035" "1.094" "1.139" "0.953" "1.001" "1.126" "0.787" "763.2" "747.9" "815.6" "789.8" "834.9" "869.4" "727.6" "763.8" "859.0" "600.3" "" "" "" "" "" "" "" "" "" "" "688.9" "576.9" "630.8" "531.8" "696.4" "742.0" "617.2" "552.8" "579.4" "600.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459435427997336669" "False" "High" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "0.000" "False" "45.405" "10" "10" "11" "9" "1041" "119.2" "6.80" "39.58" "10" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.018" "0.982" "0.935" "0.984" "0.958" "0.968" "0.965" "1.061" "1.431" "391.6" "398.5" "384.4" "366.3" "385.3" "375.3" "379.1" "377.8" "415.4" "560.5" "" "" "" "" "" "" "" "" "" "" "353.5" "307.4" "297.3" "246.6" "321.4" "320.3" "321.6" "273.4" "280.2" "560.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602347345364685954" "False" "High" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "0.000" "False" "45.385" "18" "3" "14" "3" "215" "24.9" "5.74" "46.31" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "ER-Phagosome pathway; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Suppression of HMGB1-mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "20" "0" "1.120" "1.075" "0.950" "0.899" "1.165" "0.967" "0.939" "0.972" "0.705" "718.8" "805.1" "772.8" "683.0" "646.5" "837.7" "694.7" "674.6" "698.5" "506.7" "" "" "" "" "" "" "" "" "" "" "648.8" "621.0" "597.7" "459.9" "539.2" "715.0" "589.3" "488.2" "471.1" "506.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100353375695918439" "False" "High" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "0.000" "False" "45.333" "40" "4" "20" "4" "127" "14.4" "9.60" "67.54" "4" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "1.087" "1.266" "1.033" "1.079" "1.408" "0.984" "0.993" "1.341" "0.824" "1016.4" "1105.3" "1286.9" "1050.3" "1096.7" "1431.3" "1000.6" "1008.8" "1363.1" "837.3" "" "" "" "" "" "" "" "" "" "" "917.5" "852.6" "995.4" "707.2" "914.8" "1221.6" "848.8" "730.1" "919.4" "837.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3970443704612931563" "False" "High" "IsMasterProtein" "P36578" "Large ribosomal subunit protein uL4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5" "0.000" "False" "45.233" "21" "10" "21" "10" "427" "47.7" "11.06" "63.83" "10" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00573, Pf14374" "6124" "ENSG00000174444" "RPL4" "A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.945" "1.093" "0.940" "1.084" "1.035" "1.063" "1.105" "1.016" "0.356" "1158.2" "1094.4" "1266.3" "1088.8" "1255.3" "1198.9" "1230.6" "1280.3" "1176.8" "412.9" "" "" "" "" "" "" "" "" "" "" "1045.5" "844.2" "979.4" "733.2" "1047.1" "1023.3" "1043.9" "926.6" "793.7" "412.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199308046116639924" "False" "High" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "0.000" "False" "45.201" "8" "7" "7" "5" "1337" "150.7" "7.91" "29.94" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "1" "0.952" "0.908" "1.136" "0.999" "0.785" "1.054" "0.820" "0.941" "4.080" "116.8" "111.3" "106.1" "132.7" "116.7" "91.7" "123.1" "95.8" "109.9" "476.5" "" "" "" "" "" "" "" "" "" "" "105.4" "85.8" "82.1" "89.4" "97.4" "78.3" "104.5" "69.4" "74.2" "476.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5250221047475229599" "False" "High" "IsMasterProtein" "Q7LBC6" "Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2" "0.000" "False" "45.198" "5" "8" "11" "8" "1761" "191.5" "7.18" "36.04" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "51780" "ENSG00000120733" "KDM3B" "A6H8X7; hsa:51780; Q7LBC6; Q9BVH6; Q9BW93; Q9BZ52; Q9NYF4; Q9UPS0" "HDMs demethylate histones" "Thermogenesis" "2" "0" "0.893" "0.938" "1.095" "1.040" "1.015" "0.987" "0.835" "1.014" "3.037" "178.0" "159.0" "167.0" "195.0" "185.1" "180.8" "175.8" "148.6" "180.5" "540.6" "" "" "" "" "" "" "" "" "" "" "160.7" "122.7" "129.1" "131.3" "154.4" "154.3" "149.1" "107.5" "121.8" "540.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167307694424558965" "False" "High" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "0.000" "False" "45.192" "26" "6" "13" "6" "258" "27.5" "6.05" "40.37" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate pathway" "Pentose phosphate metabolism" "2" "0" "0.929" "0.947" "0.979" "0.985" "0.922" "0.985" "0.916" "0.993" "0.697" "499.9" "464.3" "473.4" "489.2" "492.3" "460.9" "492.3" "457.9" "496.7" "348.5" "" "" "" "" "" "" "" "" "" "" "451.3" "358.1" "366.2" "329.4" "410.7" "393.3" "417.6" "331.4" "335.0" "348.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100210059596347713" "False" "High" "IsMasterProtein" "P04899" "Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3" "0.000" "False" "45.169" "24" "7" "11" "4" "355" "40.4" "5.54" "34.71" "7" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2771" "ENSG00000114353" "GNAI2" "B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion" "Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "22" "2" "1.028" "0.894" "1.074" "1.003" "0.923" "1.009" "1.054" "0.869" "0.837" "176.2" "181.1" "157.5" "189.2" "176.7" "162.6" "177.7" "185.7" "153.1" "147.5" "" "" "" "" "" "" "" "" "" "" "159.1" "139.7" "121.8" "127.4" "147.4" "138.8" "150.7" "134.4" "103.3" "147.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819248738273411506" "False" "High" "IsMasterProtein" "O14981" "TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2" "0.000" "False" "45.147" "6" "10" "13" "10" "1849" "206.8" "6.52" "33.71" "10" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf12054" "9044" "ENSG00000095564" "BTAF1" "B4E0W6; hsa:9044; O14981; O43578" "" "" "0" "0" "0.983" "0.855" "1.099" "0.926" "0.798" "1.075" "0.914" "0.844" "1.446" "448.3" "440.5" "383.3" "492.5" "415.2" "358.0" "481.7" "409.7" "378.5" "648.2" "" "" "" "" "" "" "" "" "" "" "404.7" "339.8" "296.5" "331.6" "346.3" "305.5" "408.6" "296.5" "255.3" "648.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-525798378457225330" "False" "High" "IsMasterProtein" "P0CG39" "POTE ankyrin domain family member J OS=Homo sapiens OX=9606 GN=POTEJ PE=1 SV=1" "0.000" "False" "45.132" "4" "3" "48" "1" "1038" "117.3" "5.97" "163.68" "3" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022, Pf12796, Pf14915" "653781" "ENSG00000222038" "POTEJ" "hsa:653781; P0CG39" "" "" "0" "0" "0.992" "0.853" "0.799" "1.002" "1.031" "1.449" "1.328" "0.846" "0.879" "168.5" "167.2" "143.8" "134.7" "169.0" "173.7" "244.2" "223.9" "142.7" "148.2" "" "" "" "" "" "" "" "" "" "" "152.1" "129.0" "111.2" "90.7" "140.9" "148.3" "207.2" "162.0" "96.2" "148.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6712994512663593747" "False" "High" "IsMasterProtein" "Q4G0N4" "NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2" "0.000" "False" "45.123" "22" "10" "14" "10" "442" "49.4" "8.18" "41.59" "10" "other metabolic processes" "mitochondrion" "kinase activity;other molecular function" "Pf01513" "133686" "ENSG00000152620" "NADK2" "B5MC93; hsa:133686; Q4G0N4; Q6UTX5; Q96NM0" "Mitochondrial protein degradation; Nicotinate metabolism" "" "2" "0" "1.119" "1.129" "1.181" "1.013" "1.083" "1.032" "1.096" "1.150" "0.703" "880.3" "984.8" "994.2" "1039.7" "891.8" "953.4" "908.4" "965.1" "1012.1" "619.3" "" "" "" "" "" "" "" "" "" "" "794.6" "759.6" "769.0" "700.1" "743.9" "813.7" "770.6" "698.4" "682.7" "619.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557205944014884156" "False" "High" "IsMasterProtein" "P20339" "Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2" "0.000" "False" "45.068" "35" "6" "18" "3" "215" "23.6" "8.15" "50.16" "6" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5868" "ENSG00000144566" "RAB5A" "B4DJA5; hsa:5868; P20339; Q6FI44" "Synthesis of PIPs at the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; Factors involved in megakaryocyte development and platelet production; Prevention of phagosomal-lysosomal fusion; TBC/RABGAPs" "Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; Vasopressin-regulated water reabsorption" "16" "0" "1.055" "0.874" "1.109" "1.024" "0.850" "1.041" "0.950" "0.940" "0.756" "315.1" "332.4" "275.5" "349.4" "322.8" "267.9" "328.0" "299.4" "296.2" "238.3" "" "" "" "" "" "" "" "" "" "" "284.5" "256.4" "213.0" "235.3" "269.3" "228.7" "278.2" "216.7" "199.8" "238.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902692244369353681" "False" "High" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "0.000" "False" "44.940" "22" "10" "14" "10" "523" "56.5" "6.42" "35.00" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Neutrophil degranulation; HCMV Early Events; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "16" "0" "1.012" "0.800" "0.915" "0.972" "0.826" "0.981" "0.975" "0.827" "0.960" "489.9" "495.8" "392.1" "448.5" "476.2" "404.6" "480.8" "477.8" "405.4" "470.3" "" "" "" "" "" "" "" "" "" "" "442.2" "382.4" "303.3" "302.0" "397.2" "345.3" "407.9" "345.8" "273.4" "470.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4709536422529614216" "False" "High" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "0.000" "False" "44.938" "31" "8" "20" "8" "241" "26.5" "8.13" "63.38" "8" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Neutrophil degranulation" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "1.014" "1.051" "1.036" "1.043" "1.131" "1.012" "1.029" "1.126" "0.884" "961.0" "974.1" "1009.6" "996.0" "1002.1" "1086.6" "972.7" "988.5" "1081.9" "849.6" "" "" "" "" "" "" "" "" "" "" "867.5" "751.3" "780.8" "670.7" "835.9" "927.4" "825.2" "715.4" "729.7" "849.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8112712839841425381" "False" "High" "IsMasterProtein" "Q8TAQ2" "SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1" "0.000" "False" "44.903" "8" "8" "11" "7" "1214" "132.8" "5.69" "34.85" "8" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6601" "ENSG00000139613" "SMARCC2" "F8VTJ5; hsa:6601; Q59GV3; Q8TAQ2; Q92923; Q96E12; Q96GY4" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "7" "0" "0.736" "1.062" "0.749" "0.755" "0.964" "0.746" "0.633" "0.976" "2.836" "410.2" "302.0" "435.5" "307.3" "309.6" "395.3" "306.2" "259.7" "400.5" "1163.3" "" "" "" "" "" "" "" "" "" "" "370.3" "232.9" "336.9" "207.0" "258.3" "337.4" "259.7" "187.9" "270.2" "1163.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5432753500567823498" "False" "High" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "0.000" "False" "44.895" "17" "8" "20" "8" "466" "51.7" "8.32" "57.05" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "Mitochondrial protein import; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "0.985" "1.015" "1.018" "1.047" "1.092" "0.951" "0.926" "1.104" "0.716" "667.3" "657.0" "677.5" "679.0" "698.7" "728.9" "634.8" "618.1" "736.7" "477.9" "" "" "" "" "" "" "" "" "" "" "602.4" "506.8" "524.0" "457.2" "582.9" "622.1" "538.5" "447.3" "496.9" "477.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491921153129945541" "False" "High" "IsMasterProtein" "Q9UHV9" "Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1" "0.000" "False" "44.879" "46" "7" "13" "7" "154" "16.6" "6.58" "45.89" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5202" "ENSG00000143256" "PFDN2" "hsa:5202; Q9P0P7; Q9UHV9; Q9UN05" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.021" "1.036" "0.991" "0.973" "1.056" "0.975" "1.097" "0.977" "0.760" "698.2" "712.8" "723.3" "691.6" "679.5" "737.2" "680.7" "766.0" "682.2" "530.5" "" "" "" "" "" "" "" "" "" "" "630.2" "549.8" "559.4" "465.8" "566.8" "629.2" "577.5" "554.3" "460.1" "530.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607274144029287900" "False" "High" "IsMasterProtein" "O14929" "Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2" "0.000" "False" "44.860" "16" "5" "15" "5" "419" "49.5" "5.69" "39.60" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10394, Pf21183" "8520" "ENSG00000128708" "HAT1" "hsa:8520; O14929; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9" "HATs acetylate histones" "Ethanol effects on histone modifications" "2" "0" "1.035" "1.053" "1.038" "1.076" "1.006" "1.087" "1.003" "1.029" "1.254" "572.3" "592.2" "602.3" "594.3" "615.8" "575.5" "622.1" "573.8" "588.8" "717.7" "" "" "" "" "" "" "" "" "" "" "516.6" "456.8" "465.9" "400.2" "513.7" "491.2" "527.7" "415.3" "397.1" "717.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911764670660096816" "False" "High" "IsMasterProtein" "P08195" "Amino acid transporter heavy chain SLC3A2 OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "0.000" "False" "44.828" "10" "5" "9" "5" "630" "68.0" "5.01" "31.41" "5" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "8" "0" "1.077" "1.001" "1.097" "0.986" "0.867" "1.177" "1.094" "0.914" "0.628" "424.3" "457.1" "424.9" "465.3" "418.5" "368.1" "499.5" "464.1" "387.9" "266.7" "" "" "" "" "" "" "" "" "" "" "383.0" "352.6" "328.6" "313.3" "349.1" "314.2" "423.7" "335.9" "261.6" "266.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3377056009907556172" "False" "High" "IsMasterProtein" "O14745" "Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=NHERF1 PE=1 SV=4" "0.000" "False" "44.808" "27" "8" "14" "8" "358" "38.8" "5.77" "46.80" "8" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf00595, Pf09007" "9368" "ENSG00000109062" "NHERF1" "B3KY21; hsa:9368; O14745; O43552; Q86WQ5" "" "TAR syndrome" "1" "0" "0.911" "0.950" "0.973" "0.899" "1.023" "0.853" "0.971" "0.929" "0.692" "587.3" "534.8" "558.1" "571.4" "528.1" "601.0" "500.9" "570.4" "545.8" "406.5" "" "" "" "" "" "" "" "" "" "" "530.1" "412.6" "431.7" "384.8" "440.5" "512.9" "424.9" "412.8" "368.1" "406.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6575553270224251994" "False" "High" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "0.000" "False" "44.794" "24" "10" "19" "10" "431" "49.2" "5.58" "57.45" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "4" "0" "1.039" "0.837" "0.992" "0.951" "0.888" "1.017" "0.989" "0.871" "1.036" "1349.5" "1401.8" "1130.0" "1338.4" "1284.0" "1198.4" "1373.0" "1334.9" "1174.8" "1397.8" "" "" "" "" "" "" "" "" "" "" "1218.2" "1081.2" "874.0" "901.3" "1071.1" "1022.8" "1164.7" "966.1" "792.4" "1397.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-61842363996650095" "False" "High" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "0.000" "False" "44.760" "21" "6" "19" "6" "302" "33.8" "5.49" "60.92" "6" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Metabolism of polyamines" "Methionine de novo and salvage pathway; Amino acid metabolism" "3" "0" "0.988" "0.876" "1.027" "0.981" "0.913" "0.938" "0.996" "0.872" "0.775" "885.1" "874.7" "774.9" "909.0" "868.2" "807.7" "829.9" "882.0" "771.8" "685.6" "" "" "" "" "" "" "" "" "" "" "799.0" "674.7" "599.4" "612.1" "724.3" "689.4" "704.0" "638.3" "520.6" "685.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5757828644476711483" "False" "High" "IsMasterProtein" "Q9NXR1" "Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1 PE=1 SV=3" "0.000" "False" "44.741" "41" "12" "12" "12" "335" "37.7" "5.15" "36.07" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "54820" "ENSG00000072864; ENSG00000275911" "NDE1" "hsa:54820; Q49AQ2; Q9NXR1" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "13" "0" "1.023" "0.929" "0.971" "1.015" "0.968" "0.944" "0.991" "1.030" "1.003" "566.2" "579.0" "526.2" "550.0" "574.7" "548.1" "534.3" "560.9" "583.2" "568.0" "" "" "" "" "" "" "" "" "" "" "511.1" "446.6" "407.0" "370.3" "479.4" "467.8" "453.3" "405.9" "393.3" "568.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585562482268553685" "False" "High" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "0.000" "False" "44.656" "23" "7" "13" "7" "352" "39.9" "6.54" "43.49" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "10" "0" "1.013" "1.030" "1.034" "1.079" "1.002" "1.128" "1.081" "0.965" "2.022" "861.6" "872.4" "887.4" "891.2" "929.3" "863.4" "972.2" "931.7" "831.5" "1742.4" "" "" "" "" "" "" "" "" "" "" "777.7" "672.9" "686.3" "600.2" "775.2" "736.9" "824.7" "674.2" "560.8" "1742.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4476528208765438767" "False" "High" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "0.000" "False" "44.643" "32" "6" "15" "6" "174" "19.9" "5.72" "53.55" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "6" "0" "0.896" "1.063" "0.905" "0.933" "1.011" "0.943" "0.987" "1.059" "0.936" "1325.3" "1187.9" "1408.2" "1198.8" "1236.9" "1339.5" "1250.1" "1307.6" "1403.6" "1241.0" "" "" "" "" "" "" "" "" "" "" "1196.3" "916.2" "1089.2" "807.3" "1031.8" "1143.3" "1060.5" "946.3" "946.7" "1241.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3644173202538667698" "False" "High" "IsMasterProtein" "Q9Y4B6" "DDB1- and CUL4-associated factor 1 OS=Homo sapiens OX=9606 GN=DCAF1 PE=1 SV=3" "0.000" "False" "44.547" "8" "13" "17" "13" "1507" "168.9" "5.06" "49.08" "13" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "" "9730" "ENSG00000145041" "DCAF1" "hsa:9730; Q2YD74; Q8TBD9; Q9HCA1; Q9UG37; Q9Y4B6" "Antigen processing: Ubiquitination & Proteasome degradation" "Hippo-Merlin signaling dysregulation" "2" "0" "1.010" "0.891" "1.008" "0.948" "0.969" "1.024" "0.958" "0.979" "0.941" "765.5" "772.8" "682.4" "771.4" "725.5" "741.5" "784.2" "733.1" "749.1" "720.5" "" "" "" "" "" "" "" "" "" "" "691.0" "596.1" "527.8" "519.5" "605.2" "632.9" "665.2" "530.5" "505.2" "720.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8415712224574136193" "False" "High" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "0.000" "False" "44.494" "18" "7" "12" "7" "483" "54.4" "8.66" "38.40" "7" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.031" "1.032" "1.041" "1.079" "1.047" "1.050" "0.967" "1.037" "0.919" "536.0" "552.5" "553.2" "557.9" "578.6" "561.2" "563.1" "518.3" "555.7" "492.4" "" "" "" "" "" "" "" "" "" "" "483.9" "426.2" "427.8" "375.7" "482.7" "479.0" "477.7" "375.1" "374.8" "492.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5216339322949848557" "False" "High" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "0.000" "False" "44.430" "18" "12" "14" "12" "661" "75.0" "6.37" "36.91" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.014" "0.942" "0.848" "0.962" "1.055" "0.855" "0.972" "0.990" "1.014" "491.3" "498.2" "462.9" "416.8" "472.8" "518.5" "420.2" "477.5" "486.5" "498.3" "" "" "" "" "" "" "" "" "" "" "443.5" "384.3" "358.0" "280.6" "394.4" "442.6" "356.4" "345.5" "328.1" "498.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406338825216404645" "False" "High" "IsMasterProtein" "Q16740" "ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1" "0.000" "False" "44.407" "30" "7" "15" "7" "277" "30.2" "8.09" "42.21" "7" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00574" "8192" "ENSG00000125656" "CLPP" "B2R4W5; hsa:8192; Q16740" "Mitochondrial protein degradation" "Primary ovarian insufficiency" "2" "0" "1.156" "1.213" "1.100" "1.003" "1.070" "1.146" "0.991" "1.151" "0.841" "232.1" "268.2" "281.5" "255.2" "232.9" "248.3" "265.9" "229.9" "267.0" "195.2" "" "" "" "" "" "" "" "" "" "" "209.5" "206.8" "217.7" "171.9" "194.2" "212.0" "225.6" "166.4" "180.1" "195.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2767928129327746769" "False" "High" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "0.000" "False" "44.348" "35" "5" "26" "5" "172" "19.8" "4.84" "81.85" "5" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13499" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "9" "0" "1.153" "1.021" "1.129" "1.050" "0.912" "1.062" "1.135" "1.081" "0.900" "1114.4" "1284.4" "1137.4" "1258.7" "1170.7" "1015.9" "1183.5" "1264.3" "1204.9" "1002.9" "" "" "" "" "" "" "" "" "" "" "1006.0" "990.7" "879.7" "847.6" "976.5" "867.1" "1003.9" "915.0" "812.7" "1002.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1146438711958021826" "False" "High" "IsMasterProtein" "Q16851" "UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5" "0.000" "False" "44.321" "18" "10" "19" "10" "508" "56.9" "8.15" "54.75" "10" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf01704" "7360" "ENSG00000169764" "UGP2" "hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15" "Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate" "Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation" "5" "0" "0.950" "0.963" "0.972" "1.015" "1.083" "1.016" "0.942" "1.082" "0.776" "780.5" "741.5" "751.5" "759.0" "792.5" "845.2" "793.1" "735.4" "844.5" "605.7" "" "" "" "" "" "" "" "" "" "" "704.5" "572.0" "581.2" "511.1" "661.1" "721.4" "672.8" "532.2" "569.6" "605.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4048246386295190521" "False" "High" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "0.000" "False" "44.278" "17" "7" "8" "4" "443" "49.3" "5.69" "30.29" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "Apoptotic cleavage of cellular proteins" "" "2" "2" "1.030" "0.946" "0.947" "0.976" "0.953" "1.038" "1.042" "0.877" "0.831" "409.6" "421.8" "387.5" "387.7" "399.6" "390.3" "425.1" "426.9" "359.3" "340.2" "" "" "" "" "" "" "" "" "" "" "369.7" "325.4" "299.7" "261.1" "333.4" "333.2" "360.6" "308.9" "242.4" "340.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225336690214534054" "False" "High" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "0.000" "False" "44.234" "40" "5" "12" "4" "121" "13.4" "7.24" "41.28" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "MASTL Facilitates Mitotic Progression" "" "1" "2" "1.040" "1.063" "0.969" "0.943" "0.953" "1.053" "1.127" "0.971" "0.598" "1128.2" "1173.7" "1198.7" "1093.7" "1063.4" "1075.7" "1188.0" "1271.5" "1095.2" "675.0" "" "" "" "" "" "" "" "" "" "" "1018.4" "905.3" "927.1" "736.5" "887.1" "918.1" "1007.7" "920.1" "738.7" "675.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7983353042055504763" "False" "High" "IsMasterProtein" "Q6SZW1" "NAD(+) hydrolase SARM1 OS=Homo sapiens OX=9606 GN=SARM1 PE=1 SV=1" "0.000" "False" "44.219" "12" "9" "11" "9" "724" "79.3" "6.55" "37.45" "9" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf07647, Pf13676" "23098" "ENSG00000004139" "SARM1" "hsa:23098; O60277; Q6SZW1; Q7LGG3; Q9NXY5" "" "" "0" "0" "0.942" "0.740" "1.000" "0.951" "0.773" "0.923" "0.927" "0.812" "0.848" "710.6" "669.0" "525.6" "710.8" "676.1" "549.5" "655.6" "659.0" "576.7" "602.3" "" "" "" "" "" "" "" "" "" "" "641.4" "516.1" "406.5" "478.7" "564.0" "469.0" "556.2" "476.9" "389.0" "602.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339242402032558616" "False" "High" "IsMasterProtein" "P05091" "Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH2 PE=1 SV=2" "0.000" "False" "44.217" "17" "8" "14" "7" "517" "56.3" "7.05" "42.78" "8" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00171" "217" "ENSG00000111275" "ALDH2" "B4DW54; E7EUE5; hsa:217; P05091; Q03639; Q6IB13; Q6IV71" "Mitochondrial protein degradation; Smooth Muscle Contraction; Ethanol oxidation; Metabolism of serotonin" "Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity" "8" "0" "1.037" "0.999" "1.032" "1.076" "1.022" "1.018" "1.118" "1.047" "0.714" "395.7" "410.4" "395.3" "408.4" "425.8" "404.4" "403.0" "442.4" "414.5" "282.4" "" "" "" "" "" "" "" "" "" "" "357.2" "316.6" "305.7" "275.0" "355.2" "345.2" "341.8" "320.1" "279.5" "282.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037069693652576559" "False" "High" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "0.000" "False" "44.195" "21" "7" "14" "5" "449" "49.2" "6.30" "39.14" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; P31943; Q6IBM4" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "6" "2" "1.188" "1.297" "1.224" "1.152" "1.183" "1.153" "0.997" "1.127" "4.796" "245.0" "291.0" "317.9" "300.0" "282.2" "289.7" "282.5" "244.3" "276.1" "1175.1" "" "" "" "" "" "" "" "" "" "" "221.2" "224.4" "245.9" "202.0" "235.4" "247.3" "239.7" "176.8" "186.2" "1175.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824521577804774203" "False" "High" "IsMasterProtein" "Q53GS9" "Ubiquitin carboxyl-terminal hydrolase 39 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "0.000" "False" "44.065" "18" "11" "19" "11" "565" "65.3" "8.91" "52.84" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "mRNA Splicing - Major Pathway" "" "1" "0" "1.059" "1.045" "1.008" "1.010" "1.079" "0.957" "0.983" "1.127" "0.588" "655.6" "694.1" "684.8" "660.7" "662.1" "707.2" "627.6" "644.7" "739.1" "385.6" "" "" "" "" "" "" "" "" "" "" "591.8" "535.4" "529.6" "444.9" "552.3" "603.6" "532.4" "466.6" "498.5" "385.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7059158695698353069" "False" "High" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "0.000" "False" "44.004" "40" "8" "14" "1" "201" "22.2" "5.73" "42.60" "8" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119616111706856744" "False" "High" "IsMasterProtein" "Q9ULZ3" "Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2" "0.000" "False" "43.988" "39" "7" "15" "7" "195" "21.6" "6.34" "42.25" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00619, Pf02758" "29108" "ENSG00000103490" "PYCARD" "hsa:29108; Q96D12; Q9BSZ5; Q9HBD0; Q9NXJ8; Q9ULZ3" "Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CLEC7A/inflammasome pathway" "Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling" "13" "0" "1.052" "0.936" "0.990" "1.000" "1.048" "1.004" "1.047" "1.003" "0.800" "640.6" "673.9" "599.6" "634.1" "640.6" "671.1" "643.1" "670.7" "642.4" "512.3" "" "" "" "" "" "" "" "" "" "" "578.2" "519.8" "463.8" "427.0" "534.4" "572.8" "545.5" "485.4" "433.3" "512.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4697370261215889932" "False" "High" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "0.000" "False" "43.987" "29" "5" "13" "5" "198" "22.1" "5.30" "47.73" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253, Pf21023" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "0.938" "1.015" "1.002" "0.968" "0.989" "0.983" "0.913" "1.088" "0.687" "558.6" "523.9" "567.0" "559.5" "540.5" "552.5" "549.3" "510.2" "607.6" "383.5" "" "" "" "" "" "" "" "" "" "" "504.2" "404.1" "438.5" "376.7" "450.9" "471.6" "465.9" "369.2" "409.9" "383.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833035186099414895" "False" "High" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "0.000" "False" "43.950" "8" "7" "8" "7" "1074" "116.9" "9.04" "31.63" "7" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874, Pf20965" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "" "Exercise-induced circadian regulation" "1" "0" "0.939" "0.995" "0.857" "1.010" "0.987" "1.016" "1.005" "0.903" "1.012" "278.5" "261.7" "277.2" "238.8" "281.1" "274.9" "283.1" "279.8" "251.5" "281.7" "" "" "" "" "" "" "" "" "" "" "251.4" "201.8" "214.4" "160.8" "234.5" "234.7" "240.1" "202.5" "169.6" "281.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-629472087456424791" "False" "High" "IsMasterProtein" "Q09472" "Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2" "0.000" "False" "43.906" "5" "9" "10" "7" "2414" "264.0" "8.50" "37.18" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "2033" "ENSG00000100393" "EP300" "B1AKC2; hsa:2033; Q09472" "Regulation of RUNX3 expression and activity; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Transcriptional regulation of granulopoiesis; STAT3 nuclear events downstream of ALK signaling; Attenuation phase; PPARA activates gene expression; Metalloprotease DUBs; Zygotic genome activation (ZGA); Transcriptional regulation of white adipocyte differentiation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NGF-stimulated transcription; Heme signaling; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; SUMOylation of transcription cofactors; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Methylation; NFE2L2 regulating anti-oxidant/detoxification enzymes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; NOTCH1 Intracellular Domain Regulates Transcription; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NFE2L2 regulating MDR associated enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; NOTCH3 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; CD209 (DC-SIGN) signaling; Polo-like kinase mediated events; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; RUNX3 regulates p14-ARF; Regulation of gene expression by Hypoxia-inducible Factor; PI5P Regulates TP53 Acetylation; NOTCH2 intracellular domain regulates transcription; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; IL-4 signaling pathway; Wnt signaling pathway and pluripotency; Prion disease pathway; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; CAMKK2 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; CCL18 signaling pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Urotensin-II-mediated signaling pathway; Pathophysiological roles of DUX4 in FSHD1; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "91" "2" "1.072" "0.965" "0.976" "0.997" "0.983" "1.081" "1.002" "0.880" "1.105" "654.8" "702.2" "632.0" "639.3" "652.9" "643.6" "708.1" "656.2" "576.2" "723.4" "" "" "" "" "" "" "" "" "" "" "591.1" "541.7" "488.8" "430.5" "544.6" "549.3" "600.7" "474.9" "388.6" "723.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381164833794741619" "False" "High" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "0.000" "False" "43.879" "19" "13" "17" "13" "639" "71.4" "6.40" "43.27" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf07653, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Nephrin family interactions" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "5" "0" "0.991" "1.119" "0.943" "0.934" "1.086" "0.943" "0.995" "1.074" "0.906" "1257.8" "1246.1" "1407.6" "1186.6" "1175.3" "1365.7" "1185.6" "1251.2" "1350.9" "1139.3" "" "" "" "" "" "" "" "" "" "" "1135.4" "961.2" "1088.7" "799.0" "980.4" "1165.7" "1005.7" "905.5" "911.1" "1139.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6965600281876429507" "False" "High" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "0.000" "False" "43.877" "15" "9" "14" "8" "649" "73.4" "7.88" "45.51" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; P46063" "" "Progeria-associated lipodystrophy" "1" "0" "1.117" "1.044" "1.003" "1.193" "1.177" "1.082" "1.121" "1.036" "0.809" "569.8" "636.7" "594.9" "571.7" "679.5" "670.6" "616.3" "638.8" "590.5" "460.8" "" "" "" "" "" "" "" "" "" "" "514.3" "491.1" "460.1" "385.0" "566.8" "572.3" "522.8" "462.3" "398.3" "460.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5329658274444496515" "False" "High" "IsMasterProtein" "O95394" "Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1" "0.000" "False" "43.874" "20" "10" "11" "10" "542" "59.8" "6.25" "32.88" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00408, Pf02878, Pf21404, Pf21405" "5238" "ENSG00000013375" "PGM3" "B2RB65; B4DX94; D6RF12; E1P547; E9PF86; hsa:5238; O95394; Q5JWR4; Q96J46; Q9H8G5; Q9NS94; Q9NTT6; Q9UFV5; Q9UIY2" "Synthesis of UDP-N-acetyl-glucosamine" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "3" "0" "1.004" "0.877" "0.923" "0.971" "0.954" "0.929" "0.899" "0.942" "0.962" "767.9" "770.6" "673.7" "708.8" "745.4" "732.9" "713.0" "690.6" "723.1" "738.5" "" "" "" "" "" "" "" "" "" "" "693.1" "594.4" "521.1" "477.3" "621.8" "625.5" "604.8" "499.8" "487.8" "738.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697367026041443041" "False" "High" "IsMasterProtein" "Q96A49" "Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1" "0.000" "False" "43.861" "26" "8" "15" "8" "352" "39.9" "4.53" "46.47" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03909" "94056" "ENSG00000169895" "SYAP1" "hsa:94056; Q68CP1; Q96A49; Q96C60; Q96JQ6; Q96T20" "" "" "0" "0" "1.073" "0.844" "1.038" "1.042" "0.785" "0.984" "1.035" "0.684" "0.701" "526.0" "564.4" "444.1" "546.1" "548.1" "413.1" "517.5" "544.2" "360.0" "368.5" "" "" "" "" "" "" "" "" "" "" "474.8" "435.3" "343.5" "367.7" "457.2" "352.6" "439.0" "393.8" "242.8" "368.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4783590985173723979" "False" "High" "IsMasterProtein" "Q96CN7" "Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3" "0.000" "False" "43.840" "24" "6" "12" "6" "298" "32.2" "7.39" "39.76" "6" "" "other cytoplasmic organelle;other cell component" "" "Pf00857" "51015" "ENSG00000066583" "ISOC1" "hsa:51015; Q7Z770; Q96CN7" "" "" "0" "0" "1.052" "1.019" "0.971" "0.975" "1.065" "1.068" "1.017" "1.088" "0.718" "477.1" "501.7" "486.1" "463.2" "465.3" "507.9" "509.5" "485.0" "518.9" "342.7" "" "" "" "" "" "" "" "" "" "" "430.7" "387.0" "376.0" "311.9" "388.1" "433.5" "432.2" "351.0" "350.0" "342.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1871609499973025843" "False" "High" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "0.000" "False" "43.785" "16" "3" "19" "3" "282" "31.3" "4.84" "61.16" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "8" "0" "1.001" "0.995" "1.017" "0.948" "0.977" "0.975" "1.068" "1.001" "0.829" "746.5" "747.1" "742.4" "759.2" "708.0" "729.4" "727.5" "797.5" "747.1" "618.8" "" "" "" "" "" "" "" "" "" "" "673.9" "576.3" "574.2" "511.3" "590.6" "622.6" "617.1" "577.1" "503.9" "618.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6706450895826488783" "False" "High" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "0.000" "False" "43.775" "20" "4" "10" "4" "264" "29.6" "6.15" "34.34" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "Ciliary landscape" "5" "0" "1.132" "0.958" "0.926" "0.962" "0.995" "1.056" "1.090" "0.934" "0.761" "271.1" "307.0" "259.8" "251.0" "260.7" "269.8" "286.3" "295.4" "253.3" "206.3" "" "" "" "" "" "" "" "" "" "" "244.8" "236.8" "201.0" "169.0" "217.5" "230.3" "242.8" "213.8" "170.8" "206.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6441918618070782743" "False" "High" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "0.000" "False" "43.759" "8" "14" "19" "14" "2035" "208.6" "7.46" "52.06" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415, Pf13854" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "Mitochondrial gene expression; Pleural mesothelioma" "6" "0" "0.990" "0.958" "0.994" "1.004" "0.939" "0.974" "1.030" "0.978" "0.973" "838.3" "829.9" "802.7" "833.6" "842.1" "787.6" "816.2" "863.9" "819.6" "815.8" "" "" "" "" "" "" "" "" "" "" "756.7" "640.1" "620.9" "561.3" "702.5" "672.2" "692.3" "625.2" "552.8" "815.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8235165147539186554" "False" "High" "IsMasterProtein" "Q16666" "Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3" "0.000" "False" "43.587" "12" "8" "10" "8" "785" "88.2" "9.28" "31.60" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "3428" "ENSG00000163565" "IFI16" "A0A346JEQ3; B4DJT8; H3BLV7; hsa:3428; Q16666; Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; Q9UH78" "IRF3-mediated induction of type I IFN" "" "2" "0" "1.135" "1.030" "1.109" "1.101" "1.144" "1.041" "0.599" "1.098" "5.810" "491.0" "557.1" "505.7" "544.6" "540.7" "561.7" "511.1" "293.9" "538.9" "2852.5" "" "" "" "" "" "" "" "" "" "" "443.2" "429.7" "391.1" "366.8" "451.0" "479.4" "433.6" "212.7" "363.5" "2852.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2537127350626285919" "False" "High" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "0.000" "False" "43.563" "14" "10" "15" "10" "708" "80.5" "5.90" "43.72" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "31" "0" "0.994" "0.884" "0.937" "1.007" "0.904" "1.002" "0.974" "0.896" "1.461" "1157.5" "1150.8" "1023.5" "1084.7" "1166.1" "1046.7" "1159.2" "1127.3" "1037.0" "1690.8" "" "" "" "" "" "" "" "" "" "" "1044.8" "887.7" "791.6" "730.4" "972.7" "893.4" "983.4" "815.8" "699.4" "1690.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088552440920446999" "False" "High" "IsMasterProtein" "Q9Y570" "Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3" "0.000" "False" "43.427" "24" "8" "11" "8" "386" "42.3" "5.97" "32.88" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12697" "51400" "ENSG00000214517" "PPME1" "B3KMU6; B5MEE7; hsa:51400; J3QT22; Q8WYG8; Q9NVT5; Q9UI18; Q9Y570" "Cyclin A/B1/B2 associated events during G2/M transition" "" "1" "0" "1.031" "0.990" "0.940" "0.982" "0.944" "1.016" "0.952" "0.956" "0.803" "363.1" "374.5" "359.5" "341.3" "356.5" "342.9" "368.9" "345.8" "347.0" "291.6" "" "" "" "" "" "" "" "" "" "" "327.8" "288.9" "278.1" "229.8" "297.4" "292.7" "312.9" "250.2" "234.0" "291.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-651184813655133351" "False" "High" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "0.000" "False" "43.371" "12" "7" "8" "7" "737" "83.7" "6.18" "27.73" "7" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "12" "0" "0.970" "0.917" "0.977" "0.938" "0.882" "0.922" "0.955" "0.885" "0.762" "549.4" "532.8" "504.0" "536.7" "515.1" "484.5" "506.6" "525.0" "486.3" "418.9" "" "" "" "" "" "" "" "" "" "" "496.0" "411.0" "389.8" "361.4" "429.7" "413.5" "429.8" "379.9" "328.0" "418.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6717857941727919032" "False" "High" "IsMasterProtein" "Q8WZA9" "Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1" "0.000" "False" "43.360" "16" "9" "15" "9" "623" "62.7" "4.88" "52.78" "9" "" "" "other molecular function" "" "126298" "ENSG00000167378" "IRGQ" "B2RNP3; hsa:126298; Q8WZA9" "" "" "0" "0" "0.956" "0.929" "1.019" "1.009" "0.964" "1.022" "0.990" "0.967" "1.037" "771.0" "737.0" "716.3" "785.7" "777.9" "743.5" "788.1" "762.9" "745.3" "799.6" "" "" "" "" "" "" "" "" "" "" "695.9" "568.5" "554.0" "529.1" "648.9" "634.6" "668.6" "552.1" "502.7" "799.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293533738236197165" "False" "High" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "0.000" "False" "43.350" "50" "7" "42" "7" "108" "12.8" "5.29" "132.25" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "Post-chaperonin tubulin folding pathway" "VEGFA-VEGFR2 signaling" "2" "0" "0.961" "1.116" "1.014" "0.931" "1.108" "0.899" "1.124" "1.084" "0.682" "3161.4" "3039.0" "3528.6" "3207.0" "2942.0" "3503.2" "2840.7" "3554.1" "3425.6" "2156.5" "" "" "" "" "" "" "" "" "" "" "2853.7" "2344.1" "2729.1" "2159.6" "2454.1" "2990.0" "2409.7" "2572.1" "2310.5" "2156.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010766793389346536" "False" "High" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "0.000" "False" "43.241" "42" "6" "47" "6" "149" "16.8" "4.22" "145.21" "6" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "17" "0" "0.986" "1.095" "1.117" "1.000" "1.027" "0.998" "1.134" "1.117" "0.764" "3015.5" "2972.1" "3302.7" "3368.6" "3015.2" "3097.8" "3010.5" "3420.5" "3367.9" "2305.1" "" "" "" "" "" "" "" "" "" "" "2722.0" "2292.5" "2554.4" "2268.4" "2515.2" "2644.0" "2553.8" "2475.4" "2271.6" "2305.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4473457085686512926" "False" "High" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "0.000" "False" "43.165" "17" "6" "17" "6" "407" "42.1" "5.07" "59.39" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Ub-specific processing proteases; UCH proteinases" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "4" "0" "0.951" "0.802" "0.948" "1.005" "0.842" "1.012" "1.045" "0.752" "1.016" "617.1" "586.5" "494.8" "585.1" "620.1" "519.7" "624.7" "645.1" "463.8" "627.2" "" "" "" "" "" "" "" "" "" "" "557.0" "452.4" "382.7" "394.0" "517.3" "443.5" "529.9" "466.9" "312.9" "627.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1416539979039474058" "False" "High" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "0.000" "False" "43.128" "23" "5" "14" "5" "244" "27.3" "5.15" "48.09" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "Post-chaperonin tubulin folding pathway" "" "1" "0" "1.012" "1.045" "1.079" "1.046" "0.986" "1.063" "1.031" "1.018" "1.980" "659.6" "667.4" "689.5" "711.9" "689.9" "650.3" "701.4" "679.7" "671.7" "1306.1" "" "" "" "" "" "" "" "" "" "" "595.4" "514.8" "533.3" "479.4" "575.5" "555.0" "595.0" "491.9" "453.0" "1306.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4520162396586865811" "False" "High" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "0.000" "False" "43.115" "35" "6" "12" "3" "216" "23.5" "8.41" "36.57" "6" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "10" "1" "1.077" "1.111" "1.176" "1.084" "1.017" "1.144" "1.137" "1.069" "0.776" "269.2" "289.8" "299.0" "316.6" "291.9" "273.8" "308.1" "306.0" "287.8" "208.9" "" "" "" "" "" "" "" "" "" "" "243.0" "223.6" "231.3" "213.2" "243.5" "233.7" "261.4" "221.5" "194.1" "208.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2836831182499166141" "False" "High" "IsMasterProtein" "O00148" "ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2" "0.000" "False" "43.084" "22" "11" "20" "3" "427" "49.1" "5.68" "56.85" "11" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "10212" "ENSG00000123136" "DDX39A" "B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "5" "1.117" "0.922" "1.163" "1.149" "1.037" "1.065" "1.029" "1.018" "1.652" "485.1" "542.0" "447.1" "564.3" "557.2" "502.8" "516.6" "499.4" "493.9" "801.4" "" "" "" "" "" "" "" "" "" "" "437.9" "418.0" "345.8" "380.0" "464.8" "429.2" "438.2" "361.4" "333.1" "801.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2799145337949175211" "False" "High" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "0.000" "False" "43.076" "9" "10" "13" "10" "1046" "116.9" "6.70" "44.68" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Regulation of necroptotic cell death; HATs acetylate histones" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "8" "0" "0.961" "0.779" "1.033" "1.035" "0.783" "0.986" "0.978" "0.852" "1.339" "1112.1" "1068.9" "866.7" "1148.5" "1151.4" "871.1" "1096.1" "1087.8" "947.0" "1489.5" "" "" "" "" "" "" "" "" "" "" "1003.9" "824.5" "670.3" "773.4" "960.4" "743.5" "929.8" "787.2" "638.7" "1489.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "32097797701443302" "False" "High" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "0.000" "False" "43.007" "5" "10" "11" "10" "2032" "225.4" "7.80" "38.59" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21041" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "4p16.3 copy number variation" "14" "0" "0.938" "1.228" "0.867" "0.914" "1.079" "0.880" "0.749" "1.117" "2.878" "586.1" "549.8" "719.8" "508.3" "535.8" "632.3" "516.0" "439.1" "654.8" "1686.6" "" "" "" "" "" "" "" "" "" "" "529.1" "424.1" "556.7" "342.3" "446.9" "539.7" "437.7" "317.8" "441.7" "1686.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9192930488046834202" "False" "High" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "0.000" "False" "42.975" "28" "7" "19" "7" "261" "29.5" "7.72" "63.22" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "63" "0" "1.004" "1.038" "0.997" "0.995" "1.106" "0.988" "0.994" "1.133" "0.859" "1199.5" "1204.4" "1244.6" "1195.9" "1193.9" "1326.3" "1184.9" "1191.8" "1359.3" "1030.6" "" "" "" "" "" "" "" "" "" "" "1082.8" "929.0" "962.7" "805.3" "995.9" "1132.0" "1005.2" "862.5" "916.8" "1030.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314781854584049203" "False" "High" "IsMasterProtein" "O75436" "Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2" "0.000" "False" "42.943" "25" "7" "12" "6" "327" "38.1" "6.57" "37.57" "7" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "9559" "ENSG00000122958" "VPS26A" "A8MZ56; B2RDD3; hsa:9559; O75436; Q8TBH4; Q9H982" "WNT ligand biogenesis and trafficking" "" "1" "0" "1.000" "1.114" "0.629" "0.601" "0.946" "0.657" "1.032" "0.765" "0.796" "274.3" "274.3" "305.7" "172.4" "164.8" "259.4" "180.2" "283.0" "209.8" "218.4" "" "" "" "" "" "" "" "" "" "" "247.6" "211.6" "236.5" "116.1" "137.4" "221.4" "152.9" "204.8" "141.5" "218.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214504578644122811" "False" "High" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "0.000" "False" "42.938" "28" "2" "12" "2" "108" "11.9" "8.16" "41.97" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "14" "0" "1.073" "1.148" "1.008" "1.125" "1.196" "1.053" "1.213" "1.139" "0.771" "540.2" "579.4" "620.3" "544.7" "607.6" "645.8" "568.9" "655.5" "615.4" "416.7" "" "" "" "" "" "" "" "" "" "" "487.6" "446.9" "479.7" "366.8" "506.8" "551.2" "482.6" "474.4" "415.1" "416.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586713697824146806" "False" "High" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "0.000" "False" "42.895" "7" "7" "12" "7" "1132" "119.3" "5.60" "40.61" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057, Pf20960" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "1.047" "1.099" "1.091" "1.184" "1.094" "1.058" "1.042" "1.117" "1.383" "548.1" "573.8" "602.2" "598.0" "649.0" "599.4" "580.1" "570.9" "612.1" "757.8" "" "" "" "" "" "" "" "" "" "" "494.8" "442.6" "465.8" "402.7" "541.4" "511.6" "492.1" "413.2" "412.8" "757.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3013067335374835843" "False" "High" "IsMasterProtein" "Q13153" "Serine/threonine-protein kinase PAK 1 OS=Homo sapiens OX=9606 GN=PAK1 PE=1 SV=2" "0.000" "False" "42.881" "17" "7" "11" "5" "545" "60.6" "5.76" "36.25" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5058" "ENSG00000149269" "PAK1" "hsa:5058; O75561; Q13153; Q13567; Q32M53; Q32M54; Q86W79" "CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOU GTPase cycle; Generation of second messenger molecules; MAPK6/MAPK4 signaling; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; RHOQ GTPase cycle; RHOV GTPase cycle; EPHB-mediated forward signaling; Ephrin signaling; G beta:gamma signalling through CDC42; Sema3A PAK dependent Axon repulsion; Signal transduction by L1; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; DSCAM interactions; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Androgen receptor network in prostate cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway; T-cell receptor signaling pathway" "56" "0" "0.999" "1.003" "1.065" "0.981" "1.070" "0.917" "0.981" "1.063" "0.710" "585.3" "585.0" "586.9" "623.5" "574.1" "626.5" "536.7" "574.2" "622.4" "415.7" "" "" "" "" "" "" "" "" "" "" "528.4" "451.3" "453.9" "419.9" "478.9" "534.8" "455.3" "415.5" "419.8" "415.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3785691322693480288" "False" "High" "IsMasterProtein" "O95834" "Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1" "0.000" "False" "42.877" "12" "8" "12" "8" "649" "70.6" "6.32" "37.53" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "24139" "ENSG00000125746" "EML2" "B7Z3I2; B7Z3Q9; hsa:24139; K7ERL7; O95834; Q59EN8; Q8N5A2; Q9UG50" "" "" "0" "0" "0.998" "0.964" "0.973" "1.047" "1.072" "0.944" "1.016" "1.059" "0.814" "715.8" "714.4" "689.7" "696.7" "749.2" "767.3" "675.4" "727.3" "758.3" "582.7" "" "" "" "" "" "" "" "" "" "" "646.1" "551.0" "533.4" "469.2" "625.0" "654.9" "572.9" "526.3" "511.5" "582.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6367954742648610470" "False" "High" "IsMasterProtein" "Cont_E1BJK2" "Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB1 PE=3 SV=1" "0.000" "True" "42.860" "14" "6" "31" "2" "450" "50.0" "5.11" "67.31" "6" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "541271" "ENSBIXG00000020524; ENSBTAG00000018785" "TUBB1" "A0A4W2CSS1; bta:541271; E1BJK2" "" "Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway" "2" "0" "0.902" "0.758" "1.073" "1.002" "0.844" "0.886" "0.781" "0.904" "0.651" "360.8" "325.5" "273.7" "387.1" "361.6" "304.7" "319.6" "281.9" "326.1" "235.0" "" "" "" "" "" "" "" "" "" "" "325.7" "251.1" "211.7" "260.7" "301.6" "260.0" "271.1" "204.0" "219.9" "235.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3113703590403153606" "False" "High" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "0.000" "False" "42.821" "19" "5" "12" "5" "407" "43.4" "8.56" "40.88" "5" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "1.019" "0.938" "1.023" "1.011" "0.989" "1.046" "1.097" "0.979" "0.896" "434.2" "442.6" "407.1" "444.3" "438.8" "429.2" "454.0" "476.1" "425.1" "388.9" "" "" "" "" "" "" "" "" "" "" "391.9" "341.4" "314.8" "299.2" "366.0" "366.3" "385.2" "344.5" "286.7" "388.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6066576864868279087" "False" "High" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "0.000" "False" "42.810" "15" "11" "14" "11" "795" "87.1" "6.37" "44.16" "11" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "0.940" "0.881" "0.930" "0.921" "0.875" "0.956" "0.869" "0.956" "2.270" "557.8" "524.5" "491.4" "519.0" "513.6" "487.9" "533.0" "484.8" "533.4" "1266.5" "" "" "" "" "" "" "" "" "" "" "503.5" "404.6" "380.0" "349.5" "428.4" "416.4" "452.2" "350.9" "359.8" "1266.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834517730795482410" "False" "High" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "0.000" "False" "42.797" "14" "9" "12" "9" "676" "77.5" "7.75" "39.45" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf21494" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Interferon gamma signaling; VEGFR2 mediated cell proliferation; Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "47" "0" "1.041" "0.770" "0.932" "0.991" "0.729" "0.976" "0.980" "0.820" "0.929" "376.9" "392.5" "290.2" "351.2" "373.5" "274.7" "368.0" "369.5" "309.0" "350.2" "" "" "" "" "" "" "" "" "" "" "340.2" "302.8" "224.5" "236.5" "311.6" "234.5" "312.2" "267.4" "208.4" "350.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7497019614434814723" "False" "High" "IsMasterProtein" "Q9NQH7" "Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1" "0.000" "False" "42.768" "23" "9" "14" "8" "507" "57.0" "6.83" "35.42" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00557, Pf05195" "63929" "ENSG00000196236" "XPNPEP3" "B2R9G1; B7Z790; B7Z7B2; hsa:63929; Q6I9V9; Q8NDA6; Q9BV27; Q9BVH0; Q9NQH7" "" "Ciliary landscape; Ciliopathies" "2" "0" "1.012" "0.981" "1.073" "1.013" "1.000" "0.973" "1.095" "1.034" "0.677" "282.0" "285.3" "276.6" "302.7" "285.5" "282.0" "274.4" "308.8" "291.4" "190.9" "" "" "" "" "" "" "" "" "" "" "254.5" "220.1" "213.9" "203.8" "238.2" "240.7" "232.8" "223.4" "196.6" "190.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994856410542386969" "False" "High" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "0.000" "False" "42.613" "19" "13" "15" "13" "718" "81.0" "7.30" "42.14" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.107" "0.818" "0.990" "1.060" "0.762" "1.084" "1.015" "0.819" "1.326" "560.8" "620.5" "458.4" "554.9" "594.5" "427.5" "607.7" "569.0" "459.0" "743.7" "" "" "" "" "" "" "" "" "" "" "506.2" "478.6" "354.6" "373.7" "495.9" "364.9" "515.5" "411.8" "309.6" "743.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100342078982033337" "False" "High" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "0.000" "False" "42.606" "19" "9" "14" "9" "471" "52.0" "8.00" "41.19" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; RHOBTB1 GTPase cycle" "" "5" "0" "1.015" "1.202" "0.984" "1.068" "1.176" "1.015" "1.037" "1.158" "0.922" "559.8" "568.3" "672.8" "550.9" "597.9" "658.3" "568.3" "580.7" "648.0" "516.3" "" "" "" "" "" "" "" "" "" "" "505.3" "438.4" "520.3" "371.0" "498.7" "561.9" "482.1" "420.2" "437.1" "516.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314014285931232470" "False" "High" "IsMasterProtein" "P18124" "Large ribosomal subunit protein uL30 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "0.000" "False" "42.594" "24" "6" "15" "6" "248" "29.2" "10.65" "49.29" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.969" "1.182" "0.860" "0.855" "0.962" "0.884" "1.112" "0.906" "0.421" "679.6" "658.8" "803.3" "584.5" "581.1" "653.9" "600.5" "755.6" "616.0" "286.0" "" "" "" "" "" "" "" "" "" "" "613.5" "508.2" "621.3" "393.6" "484.7" "558.1" "509.4" "546.9" "415.5" "286.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769761607326504072" "False" "High" "IsMasterProtein" "Q9Y3P9" "Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3" "0.000" "False" "42.582" "9" "11" "13" "10" "1069" "121.7" "5.25" "41.09" "11" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00566, Pf00640, Pf12473" "23637" "ENSG00000011454" "RABGAP1" "B9A6L2; hsa:23637; Q05CW2; Q6ZMY1; Q9HA28; Q9P0E2; Q9UG67; Q9Y3P9" "TBC/RABGAPs" "" "1" "0" "0.977" "0.886" "1.068" "1.039" "0.878" "1.064" "0.979" "0.928" "1.412" "700.1" "684.2" "620.5" "747.5" "727.1" "615.0" "745.2" "685.2" "649.7" "988.7" "" "" "" "" "" "" "" "" "" "" "632.0" "527.7" "479.9" "503.4" "606.5" "524.9" "632.1" "495.8" "438.2" "988.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3240734639385883819" "False" "High" "IsMasterProtein" "P53004" "Biliverdin reductase A OS=Homo sapiens OX=9606 GN=BLVRA PE=1 SV=2" "0.000" "False" "42.560" "21" "6" "12" "6" "296" "33.4" "6.44" "33.38" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01408, Pf09166" "644" "ENSG00000106605" "BLVRA" "A8K747; hsa:644; O95019; P53004; Q86UX0; Q96QL4; Q9BRW8" "Cytoprotection by HMOX1; Heme degradation" "IL-10 anti-inflammatory signaling pathway" "3" "0" "0.975" "0.838" "0.991" "0.955" "0.872" "1.012" "0.969" "0.833" "0.815" "955.5" "931.1" "801.1" "947.2" "912.3" "833.6" "966.5" "926.1" "795.9" "778.2" "" "" "" "" "" "" "" "" "" "" "862.5" "718.2" "619.6" "637.8" "761.0" "711.5" "819.9" "670.2" "536.8" "778.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1150602487247342071" "False" "High" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "0.000" "False" "42.542" "29" "8" "12" "8" "307" "34.5" "6.70" "35.68" "8" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "22q11.2 copy number variation syndrome" "5" "0" "1.063" "1.074" "1.122" "1.067" "1.121" "0.958" "1.061" "1.154" "0.829" "415.2" "441.5" "445.9" "465.7" "442.9" "465.5" "397.9" "440.7" "479.3" "344.3" "" "" "" "" "" "" "" "" "" "" "374.8" "340.5" "344.8" "313.6" "369.5" "397.3" "337.5" "318.9" "323.3" "344.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692075332981007833" "False" "High" "IsMasterProtein" "Q13451" "Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2" "0.000" "False" "42.541" "20" "8" "11" "8" "457" "51.2" "5.90" "29.64" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00254, Pf00515" "2289" "ENSG00000096060" "FKBP5" "F5H7R1; hsa:2289; Q13451; Q59EB8; Q5TGM6" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; ESR-mediated signaling; MECP2 regulates neuronal receptors and channels" "Androgen receptor network in prostate cancer; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; MECP2 and associated Rett syndrome" "7" "0" "1.014" "1.030" "1.007" "0.914" "1.028" "1.006" "0.477" "1.015" "8.038" "216.3" "219.4" "222.8" "217.7" "197.8" "222.5" "217.7" "103.1" "219.7" "1738.9" "" "" "" "" "" "" "" "" "" "" "195.3" "169.3" "172.3" "146.6" "165.0" "189.9" "184.7" "74.6" "148.2" "1738.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516272036315922492" "False" "High" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "0.000" "False" "42.472" "13" "7" "16" "7" "639" "68.3" "8.98" "53.87" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.006" "1.012" "0.967" "1.062" "1.043" "0.976" "1.030" "0.995" "0.682" "1067.2" "1073.9" "1080.3" "1032.2" "1133.0" "1112.9" "1041.1" "1098.9" "1062.4" "728.2" "" "" "" "" "" "" "" "" "" "" "963.3" "828.4" "835.5" "695.1" "945.1" "949.9" "883.1" "795.3" "716.6" "728.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1505271825198651647" "False" "High" "IsMasterProtein" "P41236" "Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2" "0.000" "False" "42.435" "26" "4" "9" "4" "205" "23.0" "4.74" "33.10" "4" "other metabolic processes;other biological processes" "" "enzyme regulator activity;other molecular function" "Pf04979" "5504" "ENSG00000184203" "PPP1R2" "hsa:5504; P41236" "" "" "0" "0" "1.047" "1.141" "0.976" "1.021" "1.086" "1.053" "1.224" "1.093" "0.739" "777.0" "813.4" "886.8" "758.6" "793.5" "844.1" "818.5" "950.9" "849.0" "573.9" "" "" "" "" "" "" "" "" "" "" "701.4" "627.4" "685.9" "510.9" "661.9" "720.4" "694.3" "688.2" "572.6" "573.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980726595472841033" "False" "High" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "0.000" "False" "42.403" "25" "7" "15" "5" "298" "33.9" "8.68" "51.33" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "47" "1" "0.961" "0.952" "0.971" "1.002" "1.021" "1.016" "0.939" "0.991" "1.389" "427.5" "410.9" "406.9" "415.1" "428.3" "436.3" "434.3" "401.5" "423.6" "594.0" "" "" "" "" "" "" "" "" "" "" "385.9" "317.0" "314.7" "279.5" "357.3" "372.4" "368.4" "290.5" "285.7" "594.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516801179277526941" "False" "High" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "0.000" "False" "42.373" "23" "6" "25" "6" "228" "26.2" "8.25" "68.00" "6" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "" "Gastric cancer network 2" "1" "0" "0.958" "0.917" "0.947" "0.901" "0.888" "0.972" "0.936" "0.907" "0.746" "1238.5" "1187.0" "1135.4" "1172.3" "1115.5" "1099.3" "1203.3" "1159.5" "1123.4" "924.2" "" "" "" "" "" "" "" "" "" "" "1117.9" "915.6" "878.2" "789.4" "930.5" "938.3" "1020.7" "839.1" "757.7" "924.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178776459123092866" "False" "High" "IsMasterProtein" "P05387" "Large ribosomal subunit protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "0.000" "False" "42.307" "37" "4" "22" "4" "115" "11.7" "4.54" "64.29" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "16" "0" "0.970" "1.135" "1.059" "0.964" "1.108" "0.950" "1.065" "1.154" "0.482" "732.7" "711.0" "831.8" "775.8" "706.6" "811.6" "696.3" "780.0" "845.4" "353.3" "" "" "" "" "" "" "" "" "" "" "661.4" "548.4" "643.3" "522.5" "589.4" "692.7" "590.6" "564.5" "570.2" "353.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-508494988063673287" "False" "High" "IsMasterProtein" "Q9NXG2" "THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2" "0.000" "False" "42.304" "17" "6" "12" "6" "353" "39.3" "7.88" "40.98" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02926" "55623" "ENSG00000066654" "THUMPD1" "hsa:55623; Q9BWC3; Q9NXG2" "rRNA modification in the nucleus and cytosol" "" "1" "0" "0.934" "1.037" "0.940" "0.951" "1.036" "0.982" "1.016" "1.039" "0.766" "957.4" "893.8" "992.4" "900.1" "910.6" "991.4" "939.7" "972.2" "994.4" "732.9" "" "" "" "" "" "" "" "" "" "" "864.2" "689.4" "767.6" "606.1" "759.6" "846.2" "797.1" "703.6" "670.7" "732.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178646061152564690" "False" "High" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "0.000" "False" "42.109" "13" "4" "6" "4" "356" "40.5" "8.34" "28.18" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "1.056" "0.775" "0.954" "1.012" "0.805" "1.064" "1.082" "0.906" "0.790" "389.4" "411.3" "301.9" "371.5" "394.1" "313.4" "414.4" "421.4" "352.7" "307.8" "" "" "" "" "" "" "" "" "" "" "351.5" "317.2" "233.5" "250.2" "328.7" "267.5" "351.6" "305.0" "237.9" "307.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669002677123591675" "False" "High" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "0.000" "False" "41.916" "27" "7" "16" "5" "297" "34.1" "8.40" "46.43" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "Golgi Cisternae Pericentriolar Stack Reorganization; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "50" "0" "1.018" "0.890" "1.071" "1.068" "0.912" "1.022" "0.971" "0.913" "1.784" "543.7" "553.7" "484.0" "582.1" "580.5" "496.0" "555.9" "528.2" "496.3" "970.1" "" "" "" "" "" "" "" "" "" "" "490.8" "427.1" "374.3" "392.0" "484.2" "423.3" "471.6" "382.2" "334.8" "970.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8827666052570193854" "False" "High" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "0.000" "False" "41.846" "26" "7" "18" "7" "248" "27.4" "7.23" "51.60" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "Translation factors; 7q11.23 copy number variation syndrome" "7" "0" "0.951" "0.782" "1.100" "0.987" "0.836" "0.996" "1.084" "0.871" "0.946" "843.6" "802.6" "659.8" "927.7" "832.6" "705.3" "840.2" "914.9" "735.1" "798.1" "" "" "" "" "" "" "" "" "" "" "761.5" "619.1" "510.3" "624.7" "694.6" "602.0" "712.7" "662.1" "495.8" "798.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "412989267492622894" "False" "High" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "0.000" "False" "41.821" "18" "7" "13" "7" "501" "58.8" "5.38" "42.78" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "mRNA Splicing - Major Pathway" "Exercise-induced circadian regulation; mRNA processing" "3" "0" "1.068" "1.130" "1.154" "0.952" "1.092" "0.938" "0.934" "1.202" "1.413" "313.1" "334.5" "354.0" "361.5" "298.2" "342.1" "293.8" "292.4" "376.4" "442.4" "" "" "" "" "" "" "" "" "" "" "282.7" "258.0" "273.8" "243.4" "248.7" "292.0" "249.3" "211.6" "253.9" "442.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3460049962588220827" "False" "High" "IsMasterProtein" "Q96CX2" "BTB/POZ domain-containing protein KCTD12 OS=Homo sapiens OX=9606 GN=KCTD12 PE=1 SV=1" "0.000" "False" "41.812" "26" "7" "12" "7" "325" "35.7" "5.64" "39.14" "7" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02214" "115207" "ENSG00000178695" "KCTD12" "hsa:115207; Q96CX2" "" "" "0" "0" "0.940" "0.887" "0.893" "1.018" "0.978" "0.931" "0.950" "1.047" "0.717" "397.2" "373.4" "352.1" "354.9" "404.4" "388.4" "369.9" "377.3" "416.0" "284.7" "" "" "" "" "" "" "" "" "" "" "358.6" "288.0" "272.4" "239.0" "337.3" "331.5" "313.8" "273.0" "280.6" "284.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993945663539599820" "False" "High" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "0.000" "False" "41.743" "37" "7" "12" "4" "200" "22.5" "8.38" "41.92" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; RAB geranylgeranylation" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "5" "0" "0.995" "1.157" "0.965" "0.964" "1.167" "0.968" "1.082" "1.160" "0.881" "483.2" "480.6" "559.3" "466.5" "465.9" "563.8" "467.6" "522.8" "560.4" "425.8" "" "" "" "" "" "" "" "" "" "" "436.2" "370.7" "432.6" "314.1" "388.6" "481.2" "396.6" "378.3" "378.0" "425.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629412907813045008" "False" "High" "IsMasterProtein" "Q14997" "Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2" "0.000" "False" "41.736" "5" "8" "9" "8" "1843" "211.2" "6.90" "33.19" "8" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11919, Pf16507" "23198" "ENSG00000068878" "PSME4" "hsa:23198; Q14997; Q1XBG4; Q1XBG5; Q1XBG6; Q2M1Z0; Q6IPR2; Q86XF8" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "" "52" "0" "0.950" "0.896" "1.062" "0.976" "0.929" "0.925" "0.916" "0.813" "0.862" "109.9" "104.3" "98.4" "116.7" "107.2" "102.0" "101.7" "100.6" "89.4" "94.7" "" "" "" "" "" "" "" "" "" "" "99.2" "80.5" "76.1" "78.6" "89.5" "87.1" "86.2" "72.8" "60.3" "94.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5964794776079938030" "False" "High" "IsMasterProtein" "P56537" "Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1" "0.000" "False" "41.711" "33" "6" "15" "6" "245" "26.6" "4.68" "40.03" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01912" "3692" "ENSG00000242372" "EIF6" "B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5" "" "Translation factors; Genetic causes of porto-sinusoidal vascular disease" "2" "0" "1.007" "1.240" "1.028" "1.051" "1.270" "1.092" "1.064" "1.372" "0.822" "287.6" "289.6" "356.7" "295.5" "302.4" "365.2" "314.1" "306.0" "394.5" "236.3" "" "" "" "" "" "" "" "" "" "" "259.6" "223.4" "275.9" "199.0" "252.2" "311.7" "266.5" "221.4" "266.1" "236.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826261878749587371" "False" "High" "IsMasterProtein" "P39023" "Large ribosomal subunit protein uL3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "0.000" "False" "41.646" "26" "12" "25" "12" "403" "46.1" "10.18" "70.99" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.871" "1.082" "0.914" "0.933" "0.915" "0.970" "0.934" "0.918" "0.252" "1573.8" "1370.4" "1702.3" "1437.7" "1468.6" "1440.0" "1526.3" "1469.2" "1444.5" "397.1" "" "" "" "" "" "" "" "" "" "" "1420.6" "1057.1" "1316.6" "968.1" "1225.1" "1229.1" "1294.7" "1063.3" "974.3" "397.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656717572997732758" "False" "High" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "0.000" "False" "41.621" "18" "9" "19" "9" "484" "54.9" "7.11" "62.44" "9" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "Purine ribonucleoside monophosphate biosynthesis" "" "1" "0" "1.047" "1.052" "1.043" "1.067" "1.069" "1.064" "1.045" "1.099" "0.671" "1398.3" "1464.4" "1471.3" "1458.9" "1491.7" "1494.7" "1487.9" "1461.1" "1537.1" "938.7" "" "" "" "" "" "" "" "" "" "" "1262.2" "1129.6" "1138.0" "982.4" "1244.3" "1275.8" "1262.2" "1057.4" "1036.7" "938.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5340528139668487905" "False" "High" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "0.000" "False" "41.608" "13" "7" "9" "7" "613" "66.9" "8.95" "35.68" "7" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "3" "0" "0.995" "1.447" "1.035" "1.079" "1.486" "1.025" "0.984" "1.415" "0.626" "544.6" "542.1" "788.2" "563.7" "587.5" "809.2" "558.3" "535.8" "770.6" "340.8" "" "" "" "" "" "" "" "" "" "" "491.6" "418.1" "609.7" "379.6" "490.1" "690.6" "473.6" "387.7" "519.7" "340.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778599060552415361" "False" "High" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "0.000" "False" "41.448" "13" "10" "12" "10" "730" "77.5" "8.70" "35.99" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing" "4" "0" "0.974" "1.015" "1.093" "1.159" "1.088" "1.007" "0.436" "0.944" "13.316" "330.3" "321.9" "335.4" "361.2" "382.9" "359.5" "332.7" "143.9" "311.7" "4398.8" "" "" "" "" "" "" "" "" "" "" "298.2" "248.3" "259.4" "243.2" "319.4" "306.9" "282.2" "104.1" "210.3" "4398.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2904127799800100027" "False" "High" "IsMasterProtein" "Q8IYS1" "Xaa-Arg dipeptidase OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2" "0.000" "False" "41.391" "19" "8" "12" "8" "436" "47.7" "5.85" "41.47" "8" "protein metabolism;other biological processes" "nucleus" "other molecular function" "Pf01546, Pf07687" "135293" "ENSG00000146281" "PM20D2" "B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1" "" "" "0" "0" "0.992" "1.076" "0.980" "0.925" "1.138" "0.927" "0.854" "1.131" "1.058" "539.0" "534.4" "579.9" "528.0" "498.3" "613.4" "499.5" "460.4" "609.8" "570.4" "" "" "" "" "" "" "" "" "" "" "486.5" "412.2" "448.5" "355.5" "415.7" "523.5" "423.8" "333.2" "411.3" "570.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1455362657326634232" "False" "High" "IsMasterProtein" "Q02543" "Large ribosomal subunit protein eL20 OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2" "0.000" "False" "41.305" "33" "6" "14" "6" "176" "20.7" "10.71" "52.63" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01775" "6142" "ENSG00000105640" "RPL18A" "hsa:6142; Q02543" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.949" "1.103" "1.014" "1.062" "1.092" "1.048" "1.053" "1.074" "0.447" "918.5" "871.8" "1012.8" "931.0" "975.2" "1002.6" "962.7" "966.8" "986.7" "410.9" "" "" "" "" "" "" "" "" "" "" "829.1" "672.5" "783.3" "626.9" "813.5" "855.7" "816.6" "699.6" "665.5" "410.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8439683798465219975" "False" "High" "IsMasterProtein" "P08621" "U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2" "0.000" "False" "41.297" "19" "9" "12" "9" "437" "51.5" "9.94" "38.48" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf12220" "6625" "ENSG00000104852" "SNRNP70" "B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.000" "1.139" "0.978" "1.021" "1.021" "0.903" "0.840" "1.021" "0.969" "1354.8" "1354.9" "1543.3" "1324.7" "1382.7" "1383.2" "1223.5" "1138.7" "1383.4" "1312.4" "" "" "" "" "" "" "" "" "" "" "1223.0" "1045.1" "1193.6" "892.0" "1153.4" "1180.5" "1037.8" "824.1" "933.1" "1312.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658594625945977388" "False" "High" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "0.000" "False" "41.285" "14" "10" "15" "9" "706" "79.9" "6.68" "50.73" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "9" "0" "0.958" "0.775" "0.922" "0.963" "0.769" "0.921" "0.891" "0.790" "0.995" "1139.9" "1092.3" "883.7" "1050.7" "1097.6" "876.2" "1050.3" "1015.6" "900.9" "1133.7" "" "" "" "" "" "" "" "" "" "" "1029.0" "842.6" "683.5" "707.6" "915.6" "747.8" "890.9" "735.0" "607.7" "1133.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5955155913055998566" "False" "High" "IsMasterProtein" "P28062" "Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3" "0.000" "False" "41.285" "24" "6" "16" "6" "276" "30.3" "7.43" "57.21" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5696" "ENSG00000204264; ENSG00000206298; ENSG00000226201; ENSG00000230034; ENSG00000230669; ENSG00000231631; ENSG00000235715; ENSG00000236443" "PSMB8" "B0UZC0; hsa:5696; P28062; Q29824; Q5JNW6; Q5QNR8; Q96J48" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Interferon alpha/beta signaling" "Proteasome degradation; Immune response to tuberculosis" "62" "0" "0.959" "1.144" "0.831" "0.944" "1.282" "0.927" "1.128" "1.002" "0.829" "510.8" "489.8" "584.5" "424.6" "482.2" "654.8" "473.4" "576.4" "511.7" "423.6" "" "" "" "" "" "" "" "" "" "" "461.1" "377.8" "452.1" "285.9" "402.2" "558.9" "401.5" "417.1" "345.1" "423.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2652497111054879184" "False" "High" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "0.000" "False" "41.212" "18" "7" "10" "7" "468" "54.4" "5.68" "31.36" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "Detoxification of Reactive Oxygen Species" "" "1" "0" "1.062" "0.974" "1.027" "1.043" "1.098" "1.027" "1.048" "1.096" "0.814" "205.7" "218.5" "200.3" "211.2" "214.5" "226.0" "211.3" "215.5" "225.5" "167.5" "" "" "" "" "" "" "" "" "" "" "185.7" "168.6" "154.9" "142.2" "178.9" "192.9" "179.2" "156.0" "152.1" "167.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8333902830713908614" "False" "High" "IsMasterProtein" "P05388" "Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "0.000" "False" "41.171" "29" "7" "14" "7" "317" "34.3" "5.97" "36.71" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "0.961" "1.089" "1.018" "1.038" "0.973" "1.019" "1.084" "1.097" "0.365" "435.9" "418.8" "474.8" "443.7" "452.5" "424.0" "444.0" "472.6" "478.2" "159.2" "" "" "" "" "" "" "" "" "" "" "393.5" "323.1" "367.2" "298.8" "377.5" "361.9" "376.6" "342.0" "322.5" "159.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6518875519697934580" "False" "High" "IsMasterProtein" "Q92576" "PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3" "0.000" "False" "41.166" "5" "10" "11" "10" "2039" "229.3" "6.96" "35.19" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00628, Pf07500, Pf07744" "23469" "ENSG00000118482" "PHF3" "A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45" "" "" "0" "0" "1.027" "0.988" "0.932" "1.053" "0.900" "0.969" "1.030" "0.918" "0.700" "564.2" "579.3" "557.3" "525.5" "594.0" "507.8" "546.8" "581.3" "517.8" "395.2" "" "" "" "" "" "" "" "" "" "" "509.3" "446.8" "431.0" "353.9" "495.5" "433.4" "463.8" "420.7" "349.2" "395.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4862457629609710254" "False" "High" "IsMasterProtein" "Q5SW79" "Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1" "0.000" "False" "41.157" "7" "11" "12" "11" "1584" "175.2" "7.11" "35.94" "11" "" "cytosol;cytoskeleton;other cell component" "" "Pf00498, Pf15308" "9859" "ENSG00000143702; ENSG00000276725" "CEP170" "hsa:9859; O75058; Q5SW77; Q5SW78; Q5SW79; Q7LGA9; Q86W31; Q9UQ08; Q9UQ09" "" "Ciliary landscape" "1" "0" "1.022" "1.237" "0.979" "1.090" "1.240" "1.049" "1.078" "1.218" "1.213" "882.5" "901.6" "1091.9" "863.5" "961.5" "1094.7" "925.8" "951.1" "1074.9" "1070.0" "" "" "" "" "" "" "" "" "" "" "796.6" "695.4" "844.5" "581.5" "802.1" "934.3" "785.3" "688.3" "725.0" "1070.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-693009755778798309" "False" "High" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=5" "0.000" "False" "41.148" "29" "5" "10" "5" "215" "24.7" "8.51" "35.29" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00957, Pf13774" "9554" "ENSG00000265808" "SEC22B" "A8K1G0; hsa:9554; O75396" "COPI-dependent Golgi-to-ER retrograde traffic; ER-Phagosome pathway; COPII-mediated vesicle transport; Cargo concentration in the ER" "" "4" "0" "1.098" "1.225" "0.966" "1.131" "1.312" "1.033" "1.080" "1.244" "0.798" "386.9" "424.7" "474.0" "373.6" "437.7" "507.7" "399.8" "417.7" "481.5" "308.6" "" "" "" "" "" "" "" "" "" "" "349.2" "327.6" "366.6" "251.6" "365.1" "433.3" "339.1" "302.3" "324.8" "308.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591250137459754120" "False" "High" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "0.000" "False" "41.131" "15" "10" "13" "10" "624" "70.8" "6.86" "39.47" "10" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "Sulfation biotransformation reaction" "4" "0" "0.960" "0.989" "0.955" "1.039" "0.910" "1.025" "1.013" "0.981" "0.741" "663.6" "637.2" "656.6" "633.5" "689.7" "603.6" "680.0" "672.2" "651.1" "491.5" "" "" "" "" "" "" "" "" "" "" "599.0" "491.5" "507.8" "426.6" "575.4" "515.2" "576.8" "486.4" "439.2" "491.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9022416781062355686" "False" "High" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "0.000" "False" "41.124" "5" "14" "15" "13" "2620" "294.2" "6.14" "42.74" "14" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf00443" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "Ub-specific processing proteases" "" "1" "0" "1.042" "0.903" "1.031" "1.107" "0.910" "1.035" "0.916" "0.915" "1.080" "455.3" "474.3" "411.2" "469.3" "504.1" "414.2" "471.1" "416.9" "416.4" "491.7" "" "" "" "" "" "" "" "" "" "" "411.0" "365.9" "318.0" "316.0" "420.5" "353.5" "399.7" "301.7" "280.8" "491.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5080369595642031285" "False" "High" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "0.000" "False" "41.107" "24" "6" "12" "6" "233" "26.0" "4.79" "38.54" "6" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "1.021" "1.131" "0.971" "1.017" "1.124" "1.023" "1.019" "1.102" "1.018" "675.4" "689.8" "764.0" "655.6" "686.6" "759.4" "690.8" "688.3" "744.1" "687.8" "" "" "" "" "" "" "" "" "" "" "609.6" "532.0" "590.9" "441.5" "572.7" "648.2" "586.0" "498.1" "501.9" "687.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381305641147496779" "False" "High" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "0.000" "False" "41.092" "41" "9" "15" "9" "217" "24.3" "8.12" "49.96" "9" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "Mitochondrial protein import" "" "1" "0" "1.004" "1.139" "0.975" "0.978" "1.035" "1.022" "1.056" "1.098" "0.661" "1483.6" "1489.3" "1689.7" "1446.5" "1450.3" "1536.1" "1515.9" "1566.9" "1628.4" "981.4" "" "" "" "" "" "" "" "" "" "" "1339.2" "1148.7" "1306.9" "974.1" "1209.8" "1311.0" "1285.9" "1134.0" "1098.4" "981.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9215017324203505863" "False" "High" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "0.000" "False" "40.991" "8" "11" "13" "11" "1299" "150.0" "5.54" "35.94" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.986" "1.377" "1.054" "1.068" "1.278" "0.985" "0.910" "1.281" "1.756" "692.2" "682.2" "953.2" "729.2" "739.4" "884.6" "682.1" "629.6" "886.5" "1215.2" "" "" "" "" "" "" "" "" "" "" "624.8" "526.2" "737.2" "491.0" "616.8" "755.0" "578.6" "455.7" "598.0" "1215.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4157182932771800811" "False" "High" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "0.000" "False" "40.917" "33" "8" "16" "8" "248" "27.7" "10.36" "46.74" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "0" "0.967" "1.058" "0.926" "1.034" "1.089" "0.932" "0.886" "0.979" "0.983" "930.3" "900.0" "984.0" "861.1" "961.7" "1013.3" "866.7" "824.6" "911.1" "914.2" "" "" "" "" "" "" "" "" "" "" "839.8" "694.2" "761.0" "579.9" "802.2" "864.8" "735.2" "596.8" "614.5" "914.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2595781739747339031" "False" "High" "IsMasterProtein" "Q14677" "Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1" "0.000" "False" "40.864" "14" "9" "10" "9" "625" "68.2" "6.42" "35.69" "9" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "9685" "ENSG00000113282" "CLINT1" "B7Z6F8; D3DQJ6; hsa:9685; Q14677; Q8NAF1; Q96E05" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "0.931" "1.155" "0.882" "0.914" "0.986" "0.926" "0.990" "1.062" "0.907" "920.9" "857.3" "1063.2" "811.9" "842.1" "908.0" "852.4" "912.1" "977.6" "835.6" "" "" "" "" "" "" "" "" "" "" "831.3" "661.2" "822.3" "546.7" "702.5" "775.0" "723.1" "660.1" "659.4" "835.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "124053754926249858" "False" "High" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "0.000" "False" "40.797" "9" "8" "10" "7" "871" "97.6" "5.81" "35.79" "8" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "0.971" "0.895" "0.866" "0.964" "0.971" "0.971" "0.949" "0.909" "0.864" "826.1" "802.0" "739.3" "715.4" "796.4" "802.1" "802.1" "784.3" "751.2" "713.7" "" "" "" "" "" "" "" "" "" "" "745.7" "618.6" "571.8" "481.8" "664.4" "684.6" "680.4" "567.6" "506.7" "713.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9189590484777075943" "False" "High" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "0.000" "False" "40.758" "26" "5" "11" "5" "183" "20.8" "5.33" "42.41" "5" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "Transcriptional Regulation by E2F6; RNA Polymerase I Promoter Escape; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "Exercise-induced circadian regulation; Effect of progerin on genes involved in progeria; NIPBL role in DNA damage - Cornelia de Lange syndrome" "6" "0" "1.038" "1.309" "1.107" "1.026" "1.235" "1.081" "1.056" "1.299" "1.265" "849.9" "882.3" "1112.9" "940.5" "871.9" "1049.4" "918.9" "897.2" "1104.1" "1075.0" "" "" "" "" "" "" "" "" "" "" "767.1" "680.5" "860.7" "633.3" "727.3" "895.6" "779.5" "649.3" "744.7" "1075.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6460139479284416051" "False" "High" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "0.000" "False" "40.749" "13" "10" "12" "10" "904" "98.6" "8.40" "34.17" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "0.984" "1.074" "0.982" "0.981" "1.098" "0.974" "0.838" "1.069" "1.694" "336.8" "331.3" "361.6" "330.6" "330.3" "370.0" "328.2" "282.3" "360.0" "570.4" "" "" "" "" "" "" "" "" "" "" "304.0" "255.6" "279.7" "222.7" "275.5" "315.8" "278.4" "204.3" "242.8" "570.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656401588938308742" "False" "High" "IsMasterProtein" "Q14676" "Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3" "0.000" "False" "40.630" "5" "9" "11" "9" "2089" "226.5" "5.47" "38.33" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00498, Pf16589, Pf16770" "9656" "ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095" "MDC1" "A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2" "SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "9" "0" "1.109" "1.360" "1.179" "1.071" "1.442" "1.027" "1.029" "1.345" "0.982" "270.4" "299.8" "367.8" "318.9" "289.5" "389.9" "277.7" "278.2" "363.6" "265.7" "" "" "" "" "" "" "" "" "" "" "244.1" "231.2" "284.5" "214.7" "241.5" "332.8" "235.6" "201.4" "245.3" "265.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5966605329502245695" "False" "High" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "0.000" "False" "40.614" "54" "5" "51" "5" "105" "11.7" "4.92" "176.35" "5" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome" "20" "0" "0.936" "1.021" "0.960" "0.921" "0.986" "0.967" "1.043" "1.010" "0.658" "4459.2" "4172.3" "4552.1" "4281.3" "4108.6" "4398.3" "4313.2" "4653.1" "4506.0" "2936.1" "" "" "" "" "" "" "" "" "" "" "4025.2" "3218.3" "3520.7" "2883.0" "3427.3" "3754.0" "3658.8" "3367.4" "3039.3" "2936.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1376480877538073283" "False" "High" "IsMasterProtein" "Q14232" "Translation initiation factor eIF2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1" "0.000" "False" "40.594" "26" "7" "17" "7" "305" "33.7" "7.33" "49.69" "7" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "1967" "ENSG00000111361" "EIF2B1" "A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4" "Recycling of eIF2:GDP" "Translation factors" "2" "0" "0.889" "0.949" "0.989" "0.992" "0.917" "0.993" "0.928" "0.960" "0.671" "724.7" "644.5" "687.8" "716.6" "719.3" "664.4" "719.9" "672.5" "695.7" "486.1" "" "" "" "" "" "" "" "" "" "" "654.2" "497.1" "532.0" "482.6" "600.0" "567.1" "610.7" "486.7" "469.2" "486.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5285928462194255524" "False" "High" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "0.000" "False" "40.525" "12" "7" "10" "7" "665" "75.7" "6.84" "28.83" "7" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "0.922" "0.992" "0.919" "0.912" "1.059" "0.882" "0.912" "1.050" "1.669" "262.3" "241.8" "260.2" "241.0" "239.2" "277.9" "231.3" "239.3" "275.3" "437.7" "" "" "" "" "" "" "" "" "" "" "236.8" "186.5" "201.3" "162.3" "199.5" "237.2" "196.2" "173.2" "185.7" "437.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8725302829576246174" "False" "High" "IsMasterProtein" "P63151" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1" "0.000" "False" "40.343" "17" "9" "13" "6" "447" "51.7" "6.20" "41.61" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "" "5520" "ENSG00000221914" "PPP2R2A" "B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "7" "3" "0.995" "0.962" "1.020" "1.032" "1.029" "1.086" "1.046" "0.972" "0.717" "948.0" "943.1" "912.3" "967.2" "978.3" "975.4" "1029.1" "991.3" "921.1" "679.3" "" "" "" "" "" "" "" "" "" "" "855.7" "727.5" "705.6" "651.3" "816.1" "832.5" "873.0" "717.4" "621.3" "679.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3912553749902594293" "False" "High" "IsMasterProtein" "P15880" "Small ribosomal subunit protein uS5 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "0.000" "False" "40.334" "28" "9" "19" "9" "293" "31.3" "10.24" "49.25" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988; ENSG00000291931" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Regulation of expression of SLITs and ROBOs; Protein methylation; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; RMTs methylate histone arginines; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "22" "0" "0.911" "0.975" "0.960" "0.996" "0.964" "0.949" "0.929" "0.927" "0.649" "1719.6" "1567.3" "1676.0" "1651.6" "1712.8" "1656.9" "1632.0" "1597.8" "1594.0" "1116.7" "" "" "" "" "" "" "" "" "" "" "1552.2" "1209.0" "1296.3" "1112.2" "1428.8" "1414.1" "1384.4" "1156.3" "1075.1" "1116.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9162404171034655345" "False" "High" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "0.000" "False" "40.328" "10" "7" "10" "7" "722" "79.2" "6.80" "31.46" "7" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "Sialylation" "3" "0" "1.115" "0.775" "1.189" "1.047" "0.879" "1.050" "1.091" "0.871" "0.813" "209.0" "233.0" "161.9" "248.5" "218.7" "183.7" "219.5" "228.0" "182.0" "169.9" "" "" "" "" "" "" "" "" "" "" "188.6" "179.8" "125.2" "167.4" "182.4" "156.7" "186.2" "165.0" "122.8" "169.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318017384069718868" "False" "High" "IsMasterProtein" "Q9Y5B0" "RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3" "0.000" "False" "40.303" "12" "11" "12" "11" "961" "104.3" "5.27" "36.07" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00533, Pf03031, Pf09309" "9150" "ENSG00000060069" "CTDP1" "A8MY97; hsa:9150; Q7Z644; Q96BZ1; Q9Y5B0; Q9Y6F5" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "" "14" "0" "0.989" "1.681" "1.035" "0.974" "1.541" "0.928" "0.900" "1.648" "3.274" "165.6" "163.8" "278.4" "171.4" "161.2" "255.1" "153.7" "149.0" "272.9" "542.1" "" "" "" "" "" "" "" "" "" "" "149.5" "126.3" "215.3" "115.4" "134.5" "217.7" "130.4" "107.8" "184.0" "542.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-692133851352470930" "False" "High" "IsMasterProtein" "Q14376" "UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2" "0.000" "False" "40.178" "18" "5" "10" "5" "348" "38.3" "6.73" "32.11" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf16363" "2582" "ENSG00000117308" "GALE" "A0A024RAH5; B3KQ39; hsa:2582; Q14376; Q38G75; Q86W41; Q9BVE3; Q9UJB4" "Galactose catabolism; Defective GALE causes EDG" "Disorders of galactose metabolism ; UDP-derived sugars synthesis in fibroblasts" "4" "0" "1.030" "0.674" "0.895" "0.979" "0.723" "0.980" "0.985" "0.720" "0.651" "527.9" "543.8" "355.5" "472.7" "516.6" "381.8" "517.3" "519.8" "380.0" "343.6" "" "" "" "" "" "" "" "" "" "" "476.5" "419.5" "275.0" "318.3" "430.9" "325.9" "438.9" "376.2" "256.3" "343.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4495210949063335174" "False" "High" "IsMasterProtein" "Q7L576" "Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1" "0.000" "False" "40.121" "8" "10" "12" "5" "1253" "145.1" "6.90" "41.89" "10" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf05994, Pf07159" "23191" "ENSG00000273749; ENSG00000288461" "CYFIP1" "A8K6D9; hsa:23191; Q14467; Q5IED0; Q6ZSX1; Q7L576; Q9BSD9; Q9BVC7" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; G13 signaling pathway" "15" "0" "0.929" "0.808" "1.008" "0.967" "0.822" "0.979" "0.938" "0.852" "1.582" "302.8" "281.3" "244.7" "305.3" "292.8" "248.8" "296.5" "284.0" "257.8" "479.0" "" "" "" "" "" "" "" "" "" "" "273.3" "217.0" "189.3" "205.6" "244.2" "212.4" "251.5" "205.6" "173.9" "479.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338451157516248926" "False" "High" "IsMasterProtein" "Q96IZ0" "PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1" "0.000" "False" "40.119" "32" "7" "9" "7" "340" "36.5" "5.41" "33.45" "7" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "5074" "ENSG00000177425" "PAWR" "hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0" "" "" "0" "0" "1.067" "1.125" "1.047" "1.048" "1.016" "1.086" "1.143" "0.982" "0.806" "212.8" "227.1" "239.4" "222.8" "223.0" "216.2" "231.0" "243.2" "208.9" "171.5" "" "" "" "" "" "" "" "" "" "" "192.1" "175.2" "185.2" "150.0" "186.0" "184.5" "196.0" "176.0" "140.9" "171.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8479423548841098522" "False" "High" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "0.000" "False" "40.116" "25" "10" "10" "10" "382" "43.9" "7.46" "32.11" "10" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "0.969" "0.969" "0.870" "0.940" "1.053" "0.917" "0.932" "0.945" "1.253" "702.9" "681.0" "681.4" "611.4" "660.8" "740.1" "644.8" "655.3" "664.4" "881.0" "" "" "" "" "" "" "" "" "" "" "634.5" "525.3" "527.0" "411.7" "551.2" "631.7" "547.0" "474.2" "448.1" "881.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2205363031532401399" "False" "High" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "0.000" "False" "40.087" "27" "6" "10" "6" "222" "23.8" "8.38" "31.91" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "Senescence-Associated Secretory Phenotype (SASP); Separation of Sister Chromatids; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "19" "0" "0.953" "0.792" "0.880" "0.990" "0.866" "0.957" "0.975" "0.870" "0.923" "617.6" "588.8" "489.0" "543.7" "611.2" "534.9" "591.1" "602.3" "537.4" "570.1" "" "" "" "" "" "" "" "" "" "" "557.5" "454.2" "378.2" "366.2" "509.8" "456.6" "501.4" "435.9" "362.5" "570.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7242737941757580841" "False" "High" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "0.000" "False" "40.043" "25" "3" "11" "3" "237" "26.2" "4.11" "28.53" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "snRNP Assembly" "" "1" "0" "1.021" "0.946" "1.132" "1.003" "0.972" "1.105" "1.044" "1.064" "0.775" "160.7" "164.0" "152.0" "182.0" "161.2" "156.2" "177.6" "167.8" "171.1" "124.5" "" "" "" "" "" "" "" "" "" "" "145.1" "126.5" "117.5" "122.5" "134.5" "133.3" "150.6" "121.4" "115.4" "124.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "875070389354990237" "False" "High" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "0.000" "False" "39.897" "21" "7" "11" "7" "331" "36.5" "4.79" "37.76" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis induced DNA fragmentation" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "4" "0" "1.086" "1.027" "0.941" "1.036" "1.017" "1.129" "1.166" "0.954" "0.730" "588.1" "638.5" "604.0" "553.5" "609.2" "597.9" "664.0" "685.7" "560.8" "429.0" "" "" "" "" "" "" "" "" "" "" "530.9" "492.5" "467.1" "372.7" "508.2" "510.3" "563.3" "496.2" "378.3" "429.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335320329939268762" "False" "High" "IsMasterProtein" "Q9UBR2" "Cathepsin Z OS=Homo sapiens OX=9606 GN=CTSZ PE=1 SV=1" "0.000" "False" "39.881" "25" "7" "14" "7" "303" "33.8" "7.11" "47.56" "7" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112" "1522" "ENSG00000101160" "CTSZ" "B2RC40; hsa:1522; O75331; Q9UBR2; Q9UQV5; Q9UQV6" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; COPII-mediated vesicle transport; Cargo concentration in the ER; Lysosome Vesicle Biogenesis" "" "5" "0" "1.097" "1.058" "0.851" "1.016" "1.159" "0.954" "1.121" "1.043" "0.844" "1012.5" "1110.7" "1071.4" "861.2" "1028.3" "1173.5" "966.3" "1134.6" "1055.8" "854.9" "" "" "" "" "" "" "" "" "" "" "914.0" "856.7" "828.6" "579.9" "857.7" "1001.6" "819.7" "821.1" "712.1" "854.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-91982353768306611" "False" "High" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "0.000" "False" "39.861" "32" "6" "16" "6" "218" "24.6" "6.68" "45.14" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "Mesodermal commitment pathway" "4" "0" "0.906" "0.910" "0.918" "0.928" "0.974" "0.937" "0.955" "0.940" "0.666" "744.2" "674.0" "677.3" "682.9" "690.6" "724.6" "697.5" "710.7" "699.9" "495.6" "" "" "" "" "" "" "" "" "" "" "671.8" "519.9" "523.8" "459.9" "576.1" "618.5" "591.7" "514.3" "472.1" "495.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8995832376771225777" "False" "High" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "0.000" "False" "39.837" "20" "7" "10" "7" "358" "40.5" "6.18" "34.46" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response" "2" "0" "1.024" "0.927" "1.175" "1.013" "0.935" "0.990" "0.899" "0.972" "1.321" "1053.7" "1079.0" "976.7" "1238.2" "1067.6" "985.4" "1042.6" "947.5" "1024.6" "1392.2" "" "" "" "" "" "" "" "" "" "" "951.1" "832.3" "755.4" "833.8" "890.6" "841.0" "884.4" "685.7" "691.1" "1392.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7607180034342260294" "False" "High" "IsMasterProtein" "Q6P179" "Endoplasmic reticulum aminopeptidase 2 OS=Homo sapiens OX=9606 GN=ERAP2 PE=1 SV=2" "0.000" "False" "39.816" "8" "9" "17" "9" "960" "110.4" "6.71" "49.41" "9" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "64167" "ENSG00000164308" "ERAP2" "hsa:64167; Q6P179; Q7Z5K1; Q8TD32; Q8WVJ4; Q9HBX2" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "" "1" "0" "1.020" "1.007" "0.865" "0.972" "1.046" "1.004" "0.978" "1.035" "0.738" "671.8" "685.3" "676.4" "580.9" "652.8" "702.6" "674.2" "657.1" "695.6" "496.1" "" "" "" "" "" "" "" "" "" "" "606.4" "528.6" "523.1" "391.2" "544.5" "599.7" "571.9" "475.5" "469.2" "496.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375658416039081200" "False" "High" "IsMasterProtein" "Q9GZU8" "PSME3-interacting protein OS=Homo sapiens OX=9606 GN=PSME3IP1 PE=1 SV=1" "0.000" "False" "39.733" "28" "7" "9" "7" "254" "28.9" "5.45" "31.17" "7" "other biological processes" "nucleus;other cell component" "" "Pf10187" "80011" "ENSG00000172775" "PSME3IP1" "hsa:80011; Q9GZU8" "" "" "0" "0" "1.014" "0.953" "1.090" "1.210" "0.885" "1.061" "0.975" "0.908" "0.675" "849.9" "861.6" "810.1" "926.0" "1028.5" "751.9" "901.9" "828.8" "771.4" "573.8" "" "" "" "" "" "" "" "" "" "" "767.2" "664.6" "626.5" "623.6" "857.9" "641.8" "765.0" "599.8" "520.3" "573.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "699961986535192658" "False" "High" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "0.000" "False" "39.719" "32" "5" "9" "4" "191" "21.3" "8.12" "28.25" "5" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Neutrophil degranulation; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHOG GTPase cycle; RHO GTPases activate KTN1" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "8" "1" "0.896" "0.805" "0.902" "0.914" "0.795" "0.932" "0.926" "0.883" "1.018" "364.6" "326.7" "293.3" "328.9" "333.1" "290.0" "339.8" "337.5" "322.0" "371.3" "" "" "" "" "" "" "" "" "" "" "329.1" "252.0" "226.9" "221.5" "277.9" "247.5" "288.2" "244.2" "217.2" "371.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7470161461111362497" "False" "High" "IsMasterProtein" "Q7Z4S6" "Kinesin-like protein KIF21A OS=Homo sapiens OX=9606 GN=KIF21A PE=1 SV=2" "0.000" "False" "39.648" "6" "9" "10" "8" "1674" "187.1" "6.42" "30.37" "9" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00400" "55605" "ENSG00000139116" "KIF21A" "A8MX28; B0I1R9; B9EGE4; F5H0C3; F5H219; hsa:55605; Q2UVF1; Q6UKL9; Q7Z4S6; Q7Z668; Q86WZ5; Q8IVZ8; Q9C0F5; Q9NXU4; Q9Y590" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "" "2" "1" "0.948" "0.997" "1.043" "1.128" "1.060" "1.051" "0.984" "1.045" "1.761" "179.2" "169.9" "178.5" "186.9" "202.1" "190.0" "188.3" "176.4" "187.2" "315.4" "" "" "" "" "" "" "" "" "" "" "161.7" "131.0" "138.1" "125.9" "168.6" "162.1" "159.7" "127.6" "126.3" "315.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740854368523393254" "False" "High" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "0.000" "False" "39.636" "6" "4" "8" "4" "783" "87.3" "9.28" "27.48" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "10q11.21q11.23 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "4" "0" "1.041" "3.542" "1.060" "0.958" "3.082" "1.021" "0.953" "3.228" "1.235" "446.3" "464.7" "1580.6" "473.1" "427.5" "1375.5" "455.7" "425.5" "1440.7" "551.2" "" "" "" "" "" "" "" "" "" "" "402.8" "358.4" "1222.5" "318.6" "356.6" "1174.0" "386.6" "307.9" "971.7" "551.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3824226989303919527" "False" "High" "IsMasterProtein" "Q68EM7" "Rho GTPase-activating protein 17 OS=Homo sapiens OX=9606 GN=ARHGAP17 PE=1 SV=1" "0.000" "False" "39.573" "10" "9" "13" "9" "881" "95.4" "7.62" "38.28" "9" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "55114" "ENSG00000140750; ENSG00000288353" "ARHGAP17" "A8K6M6; hsa:55114; Q68EM7; Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "" "6" "0" "0.972" "0.909" "0.968" "0.965" "0.876" "1.003" "0.674" "0.920" "5.491" "614.0" "596.8" "558.2" "594.5" "592.4" "537.9" "616.1" "413.8" "564.8" "3371.4" "" "" "" "" "" "" "" "" "" "" "554.2" "460.3" "431.8" "400.4" "494.1" "459.1" "522.6" "299.4" "380.9" "3371.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6326411103029325143" "False" "High" "IsMasterProtein" "P53602" "Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1" "0.000" "False" "39.481" "19" "7" "20" "7" "400" "43.4" "7.23" "57.17" "7" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00288, Pf18376" "4597" "ENSG00000167508" "MVD" "P53602; Q53Y65" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Synthesis of Dolichyl-phosphate" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Aspirin and miRNAs; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "11" "0" "1.015" "0.959" "1.034" "1.030" "0.922" "0.989" "1.009" "0.984" "0.747" "966.9" "981.4" "927.4" "1000.1" "995.6" "891.2" "956.1" "975.9" "951.4" "722.0" "" "" "" "" "" "" "" "" "" "" "872.8" "757.0" "717.3" "673.5" "830.5" "760.7" "811.0" "706.2" "641.7" "722.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988285782465549683" "False" "High" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "0.000" "False" "39.434" "19" "8" "10" "8" "399" "44.2" "4.73" "35.65" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "DNA Damage/Telomere Stress Induced Senescence; Meiotic synapsis; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Telomere Extension By Telomerase; Removal of the Flap Intermediate from the C-strand" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "16" "0" "0.978" "0.943" "1.159" "0.958" "0.878" "0.996" "0.896" "0.954" "1.729" "618.5" "605.1" "583.4" "717.1" "592.7" "542.7" "616.0" "554.4" "589.7" "1069.1" "" "" "" "" "" "" "" "" "" "" "558.3" "466.7" "451.2" "482.9" "494.4" "463.2" "522.5" "401.2" "397.8" "1069.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216931438576770944" "False" "High" "IsMasterProtein" "Q9UK76" "Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3" "0.000" "False" "39.424" "51" "6" "19" "6" "154" "16.0" "5.60" "68.68" "6" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf17054" "51155" "ENSG00000189159" "JPT1" "B2R6K3; hsa:51155; Q53FG7; Q7Z2D2; Q7Z2F0; Q9UK76" "" "" "0" "0" "1.041" "1.088" "1.060" "1.021" "1.045" "1.045" "1.227" "1.116" "0.701" "861.8" "897.3" "937.6" "913.3" "879.5" "900.3" "900.7" "1057.4" "961.8" "604.2" "" "" "" "" "" "" "" "" "" "" "777.9" "692.1" "725.2" "615.0" "733.6" "768.4" "764.1" "765.2" "648.7" "604.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532813342924820659" "False" "High" "IsMasterProtein" "Q9Y383" "Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2" "0.000" "False" "39.403" "18" "8" "12" "7" "392" "46.5" "10.01" "33.08" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "51631" "ENSG00000146963" "LUC7L2" "B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383" "" "" "0" "1" "1.011" "1.201" "1.123" "1.085" "1.179" "1.124" "0.921" "1.183" "1.413" "445.9" "450.6" "535.3" "500.7" "483.8" "525.8" "501.3" "410.7" "527.5" "630.0" "" "" "" "" "" "" "" "" "" "" "402.5" "347.5" "414.0" "337.1" "403.5" "448.7" "425.3" "297.2" "355.8" "630.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777002652342293914" "False" "High" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "0.000" "False" "39.321" "13" "10" "12" "9" "717" "81.6" "7.14" "36.85" "10" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "mRNA Splicing - Major Pathway" "" "1" "0" "1.014" "1.083" "1.155" "1.127" "0.961" "1.040" "1.005" "1.131" "1.110" "462.1" "468.5" "500.5" "533.5" "521.0" "443.9" "480.6" "464.5" "522.7" "512.8" "" "" "" "" "" "" "" "" "" "" "417.1" "361.3" "387.1" "359.3" "434.6" "378.8" "407.6" "336.1" "352.5" "512.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6634363274650926044" "False" "High" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "0.000" "False" "39.119" "6" "10" "11" "9" "1912" "217.9" "5.86" "32.17" "10" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "Q14839; Q8IXZ5" "Potential therapeutics for SARS; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; Regulation of TP53 Activity through Acetylation; NGF-stimulated transcription" "Rett syndrome; Effect of progerin on genes involved in progeria" "9" "0" "0.823" "1.648" "1.107" "1.006" "1.640" "1.055" "0.579" "1.695" "7.554" "242.0" "199.3" "398.9" "268.0" "243.4" "396.9" "255.3" "140.0" "410.3" "1828.4" "" "" "" "" "" "" "" "" "" "" "218.5" "153.7" "308.6" "180.5" "203.1" "338.8" "216.5" "101.3" "276.8" "1828.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4061147392346931585" "False" "High" "IsMasterProtein" "P61006" "Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1" "0.000" "False" "39.076" "34" "7" "11" "2" "207" "23.7" "9.07" "36.96" "7" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "4218" "ENSG00000167461" "RAB8A" "B4DEK7; hsa:4218; P24407; P61006; Q6FHV5" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; VxPx cargo-targeting to cilium; TBC/RABGAPs" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome" "10" "0" "0.982" "1.119" "0.872" "0.927" "1.192" "0.954" "1.058" "1.366" "0.722" "154.2" "151.4" "172.5" "134.4" "142.9" "183.8" "147.1" "163.1" "210.6" "111.3" "" "" "" "" "" "" "" "" "" "" "139.2" "116.8" "133.4" "90.5" "119.2" "156.9" "124.8" "118.0" "142.0" "111.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2982172693089125932" "False" "High" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "0.000" "False" "39.037" "29" "5" "16" "5" "241" "26.4" "4.79" "52.47" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "Downstream TCR signaling; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "0.981" "1.108" "0.964" "1.059" "1.114" "1.051" "1.019" "1.142" "0.779" "769.3" "755.1" "852.4" "741.6" "814.5" "856.9" "808.8" "783.8" "878.2" "599.3" "" "" "" "" "" "" "" "" "" "" "694.5" "582.4" "659.3" "499.4" "679.4" "731.4" "686.1" "567.2" "592.3" "599.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466542288326959120" "False" "High" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "0.000" "False" "39.024" "36" "7" "24" "7" "168" "19.7" "8.43" "73.13" "7" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "0.985" "1.026" "1.099" "1.023" "1.035" "1.019" "0.985" "1.093" "0.743" "1570.8" "1548.0" "1611.2" "1725.7" "1606.7" "1625.9" "1600.6" "1547.1" "1716.9" "1167.6" "" "" "" "" "" "" "" "" "" "" "1417.9" "1194.0" "1246.2" "1162.1" "1340.2" "1387.7" "1357.7" "1119.6" "1158.0" "1167.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230612763215460817" "False" "High" "IsMasterProtein" "Q99829" "Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1" "0.000" "False" "39.015" "19" "11" "19" "11" "537" "59.0" "5.83" "54.20" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf07002" "8904" "ENSG00000214078" "CPNE1" "E1P5Q4; hsa:8904; Q6IBL3; Q99829; Q9H243; Q9NTZ7" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "" "2" "0" "1.003" "0.863" "0.968" "0.926" "0.866" "0.931" "0.962" "0.908" "0.829" "1366.5" "1370.5" "1179.0" "1322.6" "1265.4" "1183.2" "1272.6" "1314.9" "1240.8" "1133.0" "" "" "" "" "" "" "" "" "" "" "1233.5" "1057.1" "911.9" "890.7" "1055.6" "1009.9" "1079.5" "951.6" "836.9" "1133.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254798804738061271" "False" "High" "IsMasterProtein" "O60271" "C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4" "0.000" "False" "38.966" "9" "11" "13" "11" "1321" "146.1" "5.15" "37.24" "11" "transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "9043" "ENSG00000008294" "SPAG9" "A6H8U5; A8MSX0; B4DHH2; hsa:9043; O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811" "Myogenesis" "" "1" "0" "0.958" "0.886" "0.894" "0.926" "0.874" "0.884" "0.815" "0.902" "2.066" "438.6" "420.3" "388.5" "392.0" "406.2" "383.2" "387.7" "357.6" "395.6" "906.3" "" "" "" "" "" "" "" "" "" "" "395.9" "324.2" "300.4" "264.0" "338.8" "327.1" "328.9" "258.8" "266.8" "906.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1951462620907489343" "False" "High" "IsMasterProtein" "O75326" "Semaphorin-7A OS=Homo sapiens OX=9606 GN=SEMA7A PE=1 SV=1" "0.000" "False" "38.919" "11" "7" "10" "7" "666" "74.8" "7.64" "26.70" "7" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf01403, Pf01437, Pf13895" "8482" "ENSG00000138623; ENSG00000288455" "SEMA7A" "B4DDP7; F5H1S0; hsa:8482; O75326; Q1XE81; Q1XE82; Q1XE83; Q1XE84; Q3MIY5" "Other semaphorin interactions" "" "1" "0" "1.019" "0.984" "1.147" "1.085" "1.048" "1.028" "1.070" "1.042" "0.734" "762.7" "777.0" "750.6" "874.9" "827.7" "799.4" "784.1" "816.5" "795.1" "559.5" "" "" "" "" "" "" "" "" "" "" "688.5" "599.3" "580.6" "589.2" "690.4" "682.3" "665.2" "590.9" "536.3" "559.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705673583208632788" "False" "High" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "0.000" "False" "38.900" "27" "6" "12" "6" "234" "25.5" "8.51" "30.99" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Pyrimidine salvage; G1/S-Specific Transcription" "Fluoropyrimidine activity; Pyrimidine metabolism" "4" "0" "0.921" "0.791" "0.950" "0.971" "0.841" "0.962" "0.995" "0.804" "0.700" "552.1" "508.5" "436.5" "524.6" "535.9" "464.4" "531.2" "549.5" "444.1" "386.4" "" "" "" "" "" "" "" "" "" "" "498.4" "392.2" "337.6" "353.2" "447.0" "396.3" "450.6" "397.7" "299.5" "386.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980690536672084448" "False" "High" "IsMasterProtein" "Q8NHV4" "Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1" "0.000" "False" "38.875" "15" "9" "12" "9" "660" "71.9" "7.97" "37.35" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "121441" "ENSG00000139350" "NEDD1" "B0AZN0; B4E145; G3V3F1; hsa:121441; Q8NA30; Q8NHV4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.021" "0.802" "0.994" "0.945" "0.847" "0.933" "0.968" "0.820" "0.944" "691.5" "706.1" "554.8" "687.4" "653.6" "585.5" "645.5" "669.6" "567.3" "652.7" "" "" "" "" "" "" "" "" "" "" "624.2" "544.6" "429.1" "462.9" "545.2" "499.7" "547.6" "484.6" "382.7" "652.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6821815504623325969" "False" "High" "IsMasterProtein" "Q9UMX0" "Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2" "0.000" "False" "38.844" "10" "4" "9" "2" "589" "62.5" "5.11" "32.61" "4" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29979" "ENSG00000135018" "UBQLN1" "A0A024R284; hsa:29979; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; Q9UMX0" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "0" "0.911" "0.848" "1.016" "0.906" "0.883" "0.861" "0.926" "0.877" "0.685" "296.8" "270.5" "251.7" "301.7" "268.9" "262.1" "255.6" "274.7" "260.2" "203.4" "" "" "" "" "" "" "" "" "" "" "267.9" "208.6" "194.6" "203.2" "224.3" "223.7" "216.8" "198.8" "175.5" "203.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1166927996766443346" "False" "High" "IsMasterProtein" "P28482" "Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3" "0.000" "False" "38.787" "26" "10" "16" "8" "360" "41.4" "6.98" "47.20" "10" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "5594" "ENSG00000100030" "MAPK1" "A8CZ64; hsa:5594; P28482" "NPAS4 regulates expression of target genes; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Recycling pathway of L1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; NCAM signaling for neurite out-growth; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants" "IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; LTF danger signal response pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway" "208" "2" "1.056" "1.014" "1.070" "0.989" "1.040" "0.987" "1.042" "1.065" "0.727" "1254.0" "1324.4" "1271.5" "1342.1" "1240.4" "1304.3" "1237.8" "1306.1" "1335.3" "912.1" "" "" "" "" "" "" "" "" "" "" "1131.9" "1021.6" "983.4" "903.8" "1034.7" "1113.2" "1050.0" "945.2" "900.6" "912.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938619972574952291" "False" "High" "IsMasterProtein" "Q9ULW0" "Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2" "0.000" "False" "38.757" "12" "9" "10" "9" "747" "85.6" "9.23" "31.37" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06886, Pf09041, Pf12214" "22974" "ENSG00000088325" "TPX2" "hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1" "AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation" "Gastric cancer network 1" "3" "0" "1.154" "0.683" "0.997" "1.099" "0.694" "1.065" "1.027" "0.631" "0.764" "206.8" "238.7" "141.4" "206.2" "227.3" "143.5" "220.3" "212.4" "130.5" "158.1" "" "" "" "" "" "" "" "" "" "" "186.7" "184.1" "109.3" "138.8" "189.6" "122.5" "186.9" "153.7" "88.0" "158.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594033010686828793" "False" "High" "IsMasterProtein" "P48637" "Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1" "0.000" "False" "38.756" "22" "11" "17" "11" "474" "52.4" "5.92" "52.46" "11" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf03199, Pf03917" "2937" "ENSG00000100983" "GSS" "B2R697; B6F210; E1P5P9; hsa:2937; P48637; Q4TTD9" "Glutathione synthesis and recycling; Defective GSS causes GSS deficiency" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "8" "0" "1.034" "1.034" "1.112" "1.037" "1.058" "0.967" "1.012" "1.041" "0.778" "1074.6" "1111.0" "1111.4" "1195.1" "1113.8" "1136.5" "1039.2" "1087.9" "1118.7" "835.7" "" "" "" "" "" "" "" "" "" "" "970.0" "857.0" "859.6" "804.8" "929.1" "970.0" "881.5" "787.3" "754.5" "835.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8338185896590092974" "False" "High" "IsMasterProtein" "Q9H0B6" "Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1" "0.000" "False" "38.713" "13" "6" "8" "6" "622" "68.9" "7.15" "27.18" "6" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf13424" "64837" "ENSG00000174996" "KLC2" "A8MXL7; B2RDY4; hsa:64837; Q9H0B6; Q9H9C8; Q9HA20" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "6" "0" "0.948" "1.093" "1.011" "0.866" "1.301" "0.958" "0.897" "1.190" "2.015" "101.8" "96.5" "111.3" "102.9" "88.2" "132.4" "97.5" "91.3" "121.1" "205.1" "" "" "" "" "" "" "" "" "" "" "91.9" "74.4" "86.1" "69.3" "73.5" "113.0" "82.7" "66.1" "81.6" "205.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4706681870966743539" "False" "High" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=2" "0.000" "False" "38.687" "11" "7" "9" "7" "742" "82.8" "5.10" "36.84" "7" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00035, Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A0A087X0M4; A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "0.956" "0.790" "0.964" "0.965" "0.765" "0.968" "1.052" "0.834" "1.114" "774.9" "740.7" "612.1" "746.7" "747.8" "593.1" "750.5" "815.3" "646.3" "863.2" "" "" "" "" "" "" "" "" "" "" "699.5" "571.3" "473.4" "502.8" "623.8" "506.3" "636.6" "590.0" "435.9" "863.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350297391460659300" "False" "High" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "0.000" "False" "38.674" "34" "8" "12" "8" "223" "25.8" "9.54" "37.56" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.962" "1.110" "1.133" "1.025" "1.099" "1.061" "1.074" "1.073" "0.489" "587.1" "564.7" "651.4" "665.2" "601.6" "645.0" "623.1" "630.4" "629.9" "287.0" "" "" "" "" "" "" "" "" "" "" "529.9" "435.5" "503.8" "447.9" "501.9" "550.5" "528.6" "456.2" "424.9" "287.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4267228453861492918" "False" "High" "IsMasterProtein" "Q8IVM0" "Coiled-coil domain-containing protein 50 OS=Homo sapiens OX=9606 GN=CCDC50 PE=1 SV=1" "0.000" "False" "38.673" "23" "7" "16" "7" "306" "35.8" "6.65" "57.90" "7" "other biological processes" "cytosol;other cell component" "other molecular function" "Pf15295" "152137" "ENSG00000152492" "CCDC50" "hsa:152137; Q86VH7; Q8IVM0" "" "" "0" "0" "1.000" "0.974" "1.098" "1.000" "0.997" "1.019" "1.033" "1.056" "0.813" "935.0" "934.7" "911.1" "1027.1" "935.1" "932.3" "952.6" "965.7" "987.0" "760.0" "" "" "" "" "" "" "" "" "" "" "844.0" "721.0" "704.7" "691.6" "780.0" "795.7" "808.1" "698.9" "665.8" "760.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575206036117319314" "False" "High" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "0.000" "False" "38.639" "12" "8" "10" "7" "721" "82.1" "6.95" "33.00" "8" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; Q68CV3; Q9NXH5; Q9Y608" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.988" "1.110" "0.959" "1.016" "1.069" "0.979" "1.041" "1.049" "0.991" "546.6" "540.1" "606.7" "524.2" "555.6" "584.2" "535.1" "569.2" "573.5" "541.9" "" "" "" "" "" "" "" "" "" "" "493.4" "416.6" "469.3" "353.0" "463.5" "498.7" "453.9" "411.9" "386.8" "541.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625236690753071245" "False" "High" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "0.000" "False" "38.582" "31" "8" "16" "8" "227" "24.6" "7.21" "51.87" "8" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Protein repair" "Primary ovarian insufficiency" "2" "0" "0.984" "0.914" "1.024" "0.948" "0.961" "0.997" "1.002" "0.974" "0.825" "1160.3" "1141.2" "1061.0" "1188.1" "1099.6" "1114.5" "1156.8" "1162.8" "1130.6" "957.7" "" "" "" "" "" "" "" "" "" "" "1047.3" "880.3" "820.6" "800.1" "917.2" "951.2" "981.3" "841.5" "762.5" "957.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2447510198658431817" "False" "High" "IsMasterProtein" "Q9H910" "Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1" "0.000" "False" "38.554" "33" "5" "11" "5" "190" "20.1" "9.26" "41.76" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf17054" "90861" "ENSG00000206053" "JPT2" "B1AJY2; B4DLH4; hsa:90861; Q6EIC7; Q9H910" "" "" "0" "0" "1.021" "1.074" "1.018" "0.960" "0.997" "1.046" "1.040" "1.086" "0.752" "268.1" "273.6" "287.9" "273.0" "257.4" "267.3" "280.5" "278.9" "291.2" "201.5" "" "" "" "" "" "" "" "" "" "" "242.0" "211.1" "222.7" "183.8" "214.7" "228.2" "237.9" "201.8" "196.4" "201.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969393992682693722" "False" "High" "IsMasterProtein" "Q9NUJ1" "Palmitoyl-protein thioesterase ABHD10, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1" "0.000" "False" "38.537" "24" "6" "10" "6" "306" "33.9" "8.57" "33.95" "6" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00561" "55347" "ENSG00000144827" "ABHD10" "B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1" "Glucuronidation" "" "1" "0" "1.002" "1.066" "0.911" "1.023" "1.170" "1.054" "1.099" "1.028" "0.688" "328.6" "329.3" "350.3" "299.4" "336.1" "384.4" "346.2" "361.0" "337.9" "226.2" "" "" "" "" "" "" "" "" "" "" "296.6" "254.0" "270.9" "201.6" "280.4" "328.1" "293.7" "261.2" "227.9" "226.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236542177406705002" "False" "High" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "0.000" "False" "38.362" "18" "6" "10" "4" "415" "45.6" "5.58" "35.55" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "MECP2 and associated Rett syndrome" "5" "0" "1.050" "0.993" "1.074" "1.008" "1.069" "0.988" "0.794" "1.069" "4.760" "256.2" "269.0" "254.4" "275.1" "258.3" "273.8" "253.1" "203.3" "273.9" "1219.4" "" "" "" "" "" "" "" "" "" "" "231.2" "207.5" "196.8" "185.2" "215.5" "233.7" "214.7" "147.2" "184.7" "1219.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457086219515973345" "False" "High" "IsMasterProtein" "P61086" "Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3" "0.000" "False" "38.346" "28" "5" "18" "5" "200" "22.4" "5.44" "60.97" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179, Pf00627" "3093" "ENSG00000078140" "UBE2K" "A6NJC1; A8K5Y9; B2RDF8; C9JGP1; hsa:3093; O54806; P27924; P61086; Q16721; Q9CVV9; Q9Y2D3" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Negative regulators of DDX58/IFIH1 signaling" "" "3" "0" "1.012" "0.971" "1.046" "0.967" "1.042" "0.969" "0.946" "0.978" "0.726" "877.7" "888.5" "852.2" "918.4" "848.8" "914.3" "850.7" "830.0" "858.8" "637.2" "" "" "" "" "" "" "" "" "" "" "792.3" "685.3" "659.1" "618.4" "708.0" "780.3" "721.6" "600.7" "579.2" "637.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8026992804565503724" "False" "High" "IsMasterProtein" "Q13257" "Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1" "0.000" "False" "38.247" "33" "7" "12" "7" "205" "23.5" "5.08" "33.30" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02301" "4085" "ENSG00000164109" "MAD2L1" "hsa:4085; Q13257; Q53F56; Q548X9; Q6IRW7; Q8IZX3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma" "13" "0" "0.933" "1.024" "0.986" "0.921" "1.056" "0.943" "0.911" "1.069" "1.414" "974.0" "908.5" "997.0" "960.5" "897.4" "1029.0" "918.9" "887.0" "1041.7" "1377.4" "" "" "" "" "" "" "" "" "" "" "879.2" "700.7" "771.2" "646.8" "748.5" "878.3" "779.5" "641.9" "702.6" "1377.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958719848471143183" "False" "High" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "0.000" "False" "38.241" "16" "6" "16" "6" "386" "42.9" "5.30" "49.13" "6" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Branched-chain amino acid catabolism" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways" "4" "0" "1.010" "0.996" "1.026" "1.075" "1.062" "0.926" "0.940" "1.067" "0.683" "426.8" "430.9" "425.1" "438.1" "458.7" "453.1" "395.3" "401.1" "455.4" "291.4" "" "" "" "" "" "" "" "" "" "" "385.2" "332.4" "328.8" "295.0" "382.6" "386.7" "335.3" "290.2" "307.2" "291.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1626409123411173154" "False" "High" "IsMasterProtein" "Q99598" "Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1" "0.000" "False" "38.192" "27" "8" "16" "8" "290" "33.1" "6.55" "42.65" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01997" "7257" "ENSG00000116918" "TSNAX" "B1APC6; hsa:7257; Q99598" "Small interfering RNA (siRNA) biogenesis" "" "1" "0" "1.078" "1.188" "0.972" "0.985" "1.070" "1.124" "1.077" "1.074" "0.813" "562.0" "605.9" "667.4" "546.0" "553.6" "601.1" "631.9" "605.4" "603.3" "456.7" "" "" "" "" "" "" "" "" "" "" "507.3" "467.3" "516.2" "367.7" "461.8" "513.1" "536.0" "438.1" "406.9" "456.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6341568024441871550" "False" "High" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "0.000" "False" "38.120" "17" "10" "14" "9" "537" "60.1" "5.85" "40.41" "10" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "" "2" "0" "1.008" "1.029" "1.052" "1.071" "1.068" "0.963" "0.744" "1.087" "1.048" "469.0" "472.9" "482.6" "493.5" "502.5" "500.8" "451.7" "348.9" "509.6" "491.4" "" "" "" "" "" "" "" "" "" "" "423.4" "364.8" "373.3" "332.3" "419.1" "427.5" "383.1" "252.5" "343.7" "491.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2364171353668644168" "False" "High" "IsMasterProtein" "Q00653" "Nuclear factor NF-kappa-B p100 subunit OS=Homo sapiens OX=9606 GN=NFKB2 PE=1 SV=4" "0.000" "False" "38.116" "10" "8" "10" "8" "900" "96.7" "6.25" "33.60" "8" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4791" "ENSG00000077150" "NFKB2" "A8K9D9; D3DR83; hsa:4791; Q00653; Q04860; Q9BU75; Q9H471; Q9H472" "PKMTs methylate histone lysines; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; Interleukin-1 processing; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus infection in host; Breast cancer pathway; Acute viral myocarditis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "43" "0" "0.920" "1.047" "1.105" "0.978" "1.073" "0.951" "0.464" "1.089" "10.650" "261.7" "240.7" "273.9" "289.1" "256.0" "280.8" "248.8" "121.3" "284.9" "2786.8" "" "" "" "" "" "" "" "" "" "" "236.2" "185.6" "211.8" "194.7" "213.5" "239.7" "211.1" "87.8" "192.1" "2786.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240907950946080993" "False" "High" "IsMasterProtein" "Q9BV44" "tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "0.000" "False" "38.071" "21" "10" "13" "10" "507" "57.0" "6.37" "36.57" "10" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "1.003" "0.826" "0.975" "1.006" "0.753" "1.039" "1.048" "0.815" "0.865" "613.8" "615.7" "506.8" "598.2" "617.6" "461.9" "637.5" "643.4" "500.2" "530.8" "" "" "" "" "" "" "" "" "" "" "554.0" "474.9" "392.0" "402.8" "515.2" "394.2" "540.7" "465.7" "337.4" "530.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2487901490658103836" "False" "High" "IsMasterProtein" "O75995" "SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2" "0.000" "False" "38.016" "22" "5" "14" "5" "380" "41.6" "5.27" "45.25" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf00536, Pf07653, Pf12485" "54440" "ENSG00000122122" "SASH3" "A6NCH1; A8K7K8; hsa:54440; O75995; Q5JZ38" "" "" "0" "0" "0.962" "0.927" "0.874" "0.887" "0.922" "0.925" "1.006" "0.867" "0.702" "415.3" "399.6" "385.0" "363.0" "368.3" "382.8" "384.1" "418.0" "360.2" "291.4" "" "" "" "" "" "" "" "" "" "" "374.9" "308.3" "297.8" "244.4" "307.2" "326.7" "325.8" "302.5" "242.9" "291.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8046944082778510554" "False" "High" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "0.000" "False" "37.974" "27" "6" "35" "5" "198" "21.9" "5.97" "113.52" "6" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Selenium micronutrient network; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "6" "0" "1.019" "0.988" "0.904" "0.939" "1.034" "0.941" "1.025" "1.015" "0.788" "2718.6" "2770.8" "2686.5" "2457.6" "2552.6" "2811.0" "2559.0" "2786.0" "2760.5" "2142.0" "" "" "" "" "" "" "" "" "" "" "2454.0" "2137.3" "2077.9" "1654.9" "2129.3" "2399.2" "2170.8" "2016.2" "1861.9" "2142.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7556916282893625233" "False" "High" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "0.000" "False" "37.959" "31" "4" "9" "4" "200" "23.0" "8.37" "31.55" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "0.955" "1.058" "0.982" "0.987" "1.038" "0.849" "0.996" "1.010" "0.759" "388.7" "371.1" "411.3" "381.7" "383.5" "403.5" "329.9" "387.1" "392.5" "294.9" "" "" "" "" "" "" "" "" "" "" "350.8" "286.2" "318.1" "257.0" "319.9" "344.4" "279.9" "280.2" "264.7" "294.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1761615694951134021" "False" "High" "IsMasterProtein" "P62888" "Large ribosomal subunit protein eL30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "0.000" "False" "37.912" "39" "4" "18" "4" "115" "12.8" "9.63" "49.58" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Selenium metabolism and selenoproteins; Cytoplasmic ribosomal proteins" "15" "0" "0.922" "1.142" "0.920" "1.022" "0.935" "0.986" "0.988" "0.979" "0.256" "1012.4" "933.6" "1156.4" "931.8" "1034.9" "947.1" "998.7" "1000.5" "990.9" "259.3" "" "" "" "" "" "" "" "" "" "" "913.9" "720.1" "894.4" "627.5" "863.3" "808.3" "847.1" "724.0" "668.3" "259.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945585302651271031" "False" "High" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "0.000" "False" "37.867" "8" "6" "14" "6" "847" "94.6" "6.25" "51.26" "6" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "0.929" "6.024" "1.048" "1.062" "5.038" "1.092" "0.815" "5.575" "3.554" "246.4" "228.9" "1484.1" "258.3" "261.7" "1241.2" "269.1" "200.8" "1373.6" "875.6" "" "" "" "" "" "" "" "" "" "" "222.4" "176.6" "1147.9" "174.0" "218.3" "1059.4" "228.3" "145.4" "926.5" "875.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8210818149912646419" "False" "High" "IsMasterProtein" "P11216" "Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5" "0.000" "False" "37.805" "13" "13" "18" "13" "843" "96.6" "6.86" "50.96" "13" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00343" "5834" "ENSG00000100994" "PYGB" "hsa:5834; P11216; Q96AK1; Q9NPX8" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "IL-18 signaling pathway; Glycogen synthesis and degradation" "4" "0" "0.957" "0.848" "0.895" "0.976" "0.908" "0.978" "0.947" "0.891" "0.758" "886.9" "848.9" "751.8" "793.7" "865.6" "805.6" "867.1" "839.6" "789.8" "671.9" "" "" "" "" "" "" "" "" "" "" "800.6" "654.8" "581.5" "534.5" "722.1" "687.6" "735.6" "607.6" "532.7" "671.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894400129343683729" "False" "High" "IsMasterProtein" "Q9BUH6" "Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2" "0.000" "False" "37.786" "31" "5" "6" "5" "204" "21.6" "5.48" "24.15" "5" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf15384" "286257" "ENSG00000148362" "PAXX" "hsa:286257; Q8IY19; Q9BUH6" "" "" "0" "0" "1.131" "1.036" "1.176" "0.989" "1.024" "1.090" "1.087" "1.070" "0.722" "262.5" "297.0" "272.0" "308.7" "259.7" "268.9" "286.2" "285.3" "281.0" "189.5" "" "" "" "" "" "" "" "" "" "" "237.0" "229.1" "210.3" "207.9" "216.6" "229.5" "242.8" "206.5" "189.5" "189.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5921429182500705176" "False" "High" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "0.000" "False" "37.727" "21" "6" "12" "6" "313" "34.0" "4.87" "39.79" "6" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "0.912" "0.794" "1.027" "0.985" "0.804" "0.948" "0.907" "0.816" "1.028" "801.4" "730.7" "636.5" "823.0" "789.7" "644.2" "760.0" "726.9" "654.1" "823.5" "" "" "" "" "" "" "" "" "" "" "723.4" "563.6" "492.3" "554.2" "658.7" "549.9" "644.7" "526.0" "441.2" "823.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677465183251509063" "False" "High" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=3" "0.000" "False" "37.708" "40" "4" "15" "4" "121" "13.6" "4.82" "41.71" "4" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf19026" "25764" "ENSG00000242028" "HYPK" "C9JKJ0; hsa:25764; O75408; Q8WUW8; Q9NX55; Q9P024" "" "" "0" "0" "1.033" "1.048" "1.015" "1.006" "1.029" "0.990" "1.138" "1.114" "0.752" "584.5" "603.9" "612.8" "593.1" "588.1" "601.3" "578.5" "665.1" "651.1" "439.3" "" "" "" "" "" "" "" "" "" "" "527.7" "465.8" "474.0" "399.4" "490.6" "513.2" "490.7" "481.3" "439.1" "439.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7462216625703255168" "False" "High" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "0.000" "False" "37.680" "7" "7" "12" "7" "1151" "131.6" "4.98" "44.19" "7" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "1.082" "1.076" "1.007" "0.960" "1.009" "1.025" "0.974" "1.021" "1.042" "715.7" "774.0" "769.9" "720.9" "686.7" "721.8" "733.8" "697.2" "730.5" "745.5" "" "" "" "" "" "" "" "" "" "" "646.0" "597.0" "595.4" "485.4" "572.8" "616.1" "622.5" "504.6" "492.7" "745.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5761790178817742854" "False" "High" "IsMasterProtein" "Q96P70" "Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3" "0.000" "False" "37.600" "10" "11" "15" "11" "1041" "115.9" "4.81" "41.69" "11" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03810" "55705" "ENSG00000198700" "IPO9" "B1ASV5; hsa:55705; Q8N1Y1; Q8N3I2; Q8NCG9; Q96P70; Q96SU6; Q9NW01; Q9P0A8; Q9ULM8" "" "" "0" "0" "1.008" "1.296" "1.143" "1.000" "1.295" "1.056" "0.950" "1.329" "1.907" "773.5" "779.4" "1002.4" "884.4" "773.4" "1001.4" "816.9" "734.5" "1027.7" "1475.4" "" "" "" "" "" "" "" "" "" "" "698.2" "601.2" "775.3" "595.6" "645.1" "854.7" "693.0" "531.5" "693.2" "1475.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260357318160893257" "False" "High" "IsMasterProtein" "O75439" "Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2" "0.000" "False" "37.554" "16" "8" "14" "8" "489" "54.3" "6.83" "43.01" "8" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "9512" "ENSG00000105819" "PMPCB" "hsa:9512; O60416; O75439; Q96FV4" "Mitochondrial protein import; Processing of SMDT1" "" "2" "0" "1.045" "0.990" "1.024" "1.112" "1.098" "1.051" "1.105" "1.140" "0.813" "530.2" "554.0" "524.8" "542.8" "589.6" "582.0" "557.3" "586.1" "604.4" "431.1" "" "" "" "" "" "" "" "" "" "" "478.6" "427.3" "405.9" "365.6" "491.9" "496.7" "472.7" "424.1" "407.7" "431.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4018200245095699536" "False" "High" "IsMasterProtein" "P55327" "Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52 PE=1 SV=2" "0.000" "False" "37.549" "28" "4" "10" "4" "224" "24.3" "4.83" "38.56" "4" "transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf04201" "7163" "ENSG00000076554" "TPD52" "B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4; hsa:7163; P55327; Q13056; Q53EK8; Q6FGP3; Q6FGS3; Q86YZ2; Q9UCX8" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "1.042" "0.924" "0.880" "0.889" "0.971" "0.968" "1.130" "0.902" "0.682" "802.1" "835.7" "741.5" "705.9" "712.8" "778.6" "776.7" "906.3" "723.8" "547.3" "" "" "" "" "" "" "" "" "" "" "724.1" "644.6" "573.5" "475.3" "594.6" "664.6" "658.9" "655.9" "488.2" "547.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4895248664825856717" "False" "High" "IsMasterProtein" "Q9UGP4" "LIM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LIMD1 PE=1 SV=1" "0.000" "False" "37.511" "8" "4" "7" "4" "676" "72.1" "6.65" "29.38" "4" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00412" "8994" "ENSG00000144791" "LIMD1" "hsa:8994; Q17RQ1; Q9BQQ9; Q9NQ47; Q9UGP4" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Pleural mesothelioma" "3" "0" "1.125" "0.914" "1.038" "1.058" "0.977" "1.107" "1.032" "0.857" "1.198" "466.9" "525.3" "426.9" "484.9" "494.1" "456.0" "517.0" "482.1" "400.2" "559.1" "" "" "" "" "" "" "" "" "" "" "421.5" "405.2" "330.2" "326.5" "412.1" "389.2" "438.6" "348.9" "269.9" "559.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551881844425109656" "False" "High" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "0.000" "False" "37.492" "13" "7" "10" "7" "536" "61.5" "9.52" "35.14" "7" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "16" "0" "1.004" "0.943" "0.918" "0.974" "1.002" "0.906" "1.055" "1.002" "0.649" "650.0" "652.6" "613.0" "596.9" "633.3" "651.0" "589.2" "685.5" "651.6" "421.6" "" "" "" "" "" "" "" "" "" "" "586.8" "503.4" "474.1" "401.9" "528.3" "555.6" "499.8" "496.1" "439.5" "421.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2439136335340173205" "False" "High" "IsMasterProtein" "P22681" "E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2" "0.000" "False" "37.375" "11" "8" "9" "8" "906" "99.6" "6.54" "25.03" "8" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762" "867" "ENSG00000110395" "CBL" "A3KMP8; P22681" "Spry regulation of FGF signaling; Regulation of signaling by CBL; Regulation of KIT signaling; Negative regulation of FLT3; Cargo recognition for clathrin-mediated endocytosis; Interleukin-6 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Signaling by CSF1 (M-CSF) in myeloid cells; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; FLT3 signaling by CBL mutants" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Insulin signaling; IL-2 signaling pathway; 4p16.3 copy number variation; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "39" "0" "1.056" "0.936" "0.944" "0.965" "0.886" "0.957" "0.984" "0.978" "0.765" "238.8" "252.1" "223.6" "225.4" "230.4" "211.6" "228.5" "235.1" "233.6" "182.7" "" "" "" "" "" "" "" "" "" "" "215.6" "194.5" "173.0" "151.8" "192.2" "180.6" "193.8" "170.1" "157.6" "182.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5588804604694799714" "False" "High" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "0.000" "False" "37.293" "15" "7" "14" "7" "453" "48.7" "8.95" "45.99" "7" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle)" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "10" "0" "1.027" "0.945" "0.976" "0.984" "1.002" "1.004" "1.008" "0.953" "0.593" "745.5" "765.8" "704.2" "727.9" "733.9" "747.1" "748.3" "751.5" "710.6" "441.9" "" "" "" "" "" "" "" "" "" "" "672.9" "590.7" "544.7" "490.2" "612.2" "637.6" "634.8" "543.8" "479.3" "441.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "105236357953779316" "False" "High" "IsMasterProtein" "Q9H0R4" "Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1" "0.000" "False" "37.262" "19" "4" "10" "4" "259" "28.5" "6.24" "32.27" "4" "other metabolic processes" "" "other molecular function" "Pf13242, Pf13344" "84064" "ENSG00000167220" "HDHD2" "A8K7T3; hsa:84064; Q96NV4; Q9H0R4" "" "" "0" "0" "1.058" "0.945" "1.072" "1.010" "1.076" "0.992" "0.997" "1.157" "0.711" "204.2" "216.1" "193.0" "218.9" "206.4" "219.7" "202.6" "203.6" "236.3" "145.2" "" "" "" "" "" "" "" "" "" "" "184.4" "166.7" "149.3" "147.4" "172.1" "187.6" "171.9" "147.3" "159.4" "145.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291285492636401918" "False" "High" "IsMasterProtein" "Q9H974" "Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1" "0.000" "False" "37.215" "15" "5" "10" "5" "415" "46.7" "6.81" "29.83" "5" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01702" "79691" "ENSG00000151576" "QTRT2" "A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.060" "0.951" "1.011" "0.928" "1.006" "1.036" "0.965" "1.012" "0.773" "427.8" "453.6" "407.1" "432.7" "397.1" "430.5" "443.3" "412.8" "433.1" "330.7" "" "" "" "" "" "" "" "" "" "" "386.2" "349.9" "314.9" "291.4" "331.3" "367.4" "376.1" "298.7" "292.1" "330.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481599324901596636" "False" "High" "IsMasterProtein" "O75391" "Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2" "0.000" "False" "37.149" "33" "6" "8" "6" "227" "26.0" "7.91" "25.61" "6" "" "nucleus" "nucleic acid binding activity" "Pf01424" "9552" "ENSG00000091640" "SPAG7" "hsa:9552; O75391; Q96EU5" "" "" "0" "0" "1.035" "1.039" "0.990" "1.113" "1.046" "1.026" "1.089" "1.000" "0.735" "386.2" "399.7" "401.1" "382.1" "429.7" "403.8" "396.0" "420.4" "386.4" "284.0" "" "" "" "" "" "" "" "" "" "" "348.6" "308.3" "310.2" "257.3" "358.4" "344.6" "336.0" "304.2" "260.6" "284.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7717168989126712836" "False" "High" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "0.000" "False" "37.052" "12" "8" "9" "8" "677" "76.2" "7.03" "29.39" "8" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "DNA repair pathways, full network" "5" "0" "1.078" "1.031" "1.124" "1.070" "1.059" "1.090" "0.921" "1.080" "0.979" "463.5" "499.8" "477.7" "521.0" "496.1" "491.0" "505.4" "426.8" "500.5" "453.9" "" "" "" "" "" "" "" "" "" "" "418.4" "385.5" "369.5" "350.8" "413.8" "419.0" "428.7" "308.9" "337.6" "453.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3245672403803654152" "False" "High" "IsMasterProtein" "P62263" "Small ribosomal subunit protein uS11 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "0.000" "False" "37.051" "36" "5" "15" "5" "151" "16.3" "10.05" "58.50" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "0.949" "1.005" "0.968" "1.023" "0.964" "0.931" "1.009" "1.009" "0.684" "537.4" "509.8" "540.1" "520.3" "549.6" "517.9" "500.1" "542.3" "542.1" "367.8" "" "" "" "" "" "" "" "" "" "" "485.1" "393.2" "417.8" "350.4" "458.4" "442.0" "424.2" "392.4" "365.6" "367.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6570966043889327404" "False" "High" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "0.000" "False" "37.043" "10" "7" "9" "6" "767" "86.4" "6.89" "29.37" "7" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "" "Sterol regulatory element-binding proteins (SREBP) signaling" "1" "1" "0.972" "0.918" "1.074" "0.963" "0.965" "1.087" "0.979" "1.087" "1.533" "486.8" "473.3" "447.0" "522.7" "468.7" "469.8" "529.1" "476.6" "529.0" "746.1" "" "" "" "" "" "" "" "" "" "" "439.4" "365.1" "345.7" "352.0" "391.0" "401.0" "448.8" "344.9" "356.8" "746.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2599348248423270713" "False" "High" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "0.000" "False" "36.989" "18" "7" "12" "7" "451" "51.1" "6.14" "36.97" "7" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Alstrom syndrome" "8" "0" "1.111" "0.861" "0.919" "0.990" "0.878" "0.926" "0.930" "0.914" "1.080" "386.5" "429.4" "332.8" "355.3" "382.7" "339.4" "357.9" "359.6" "353.5" "417.6" "" "" "" "" "" "" "" "" "" "" "348.9" "331.2" "257.4" "239.2" "319.2" "289.7" "303.6" "260.2" "238.4" "417.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "710012249327667382" "False" "High" "IsMasterProtein" "P48449" "Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1" "0.000" "False" "36.946" "10" "7" "12" "7" "732" "83.3" "6.61" "39.90" "7" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00432" "4047" "ENSG00000160285" "LSS" "B4DJZ9; D3DSN0; E9PEI9; G5E9Q9; P48449; Q8IYL6; Q9UEZ1" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "1.032" "0.977" "1.047" "0.999" "0.973" "1.028" "0.930" "0.977" "1.153" "418.0" "431.2" "408.3" "437.7" "417.6" "406.9" "429.6" "388.6" "408.3" "481.8" "" "" "" "" "" "" "" "" "" "" "377.3" "332.6" "315.8" "294.7" "348.4" "347.3" "364.4" "281.3" "275.4" "481.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "185652229165611282" "False" "High" "IsMasterProtein" "Q9NY27" "Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3" "0.000" "False" "36.944" "29" "8" "11" "8" "417" "46.9" "4.54" "38.11" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09184" "151987" "ENSG00000163605" "PPP4R2" "A8K1I6; hsa:151987; Q2TAJ9; Q498B8; Q8WXX6; Q9NY27" "Processing of DNA double-strand break ends" "16p11.2 proximal deletion syndrome" "2" "0" "1.057" "0.987" "0.998" "0.971" "0.985" "0.978" "1.093" "0.974" "1.002" "848.1" "896.8" "837.2" "846.3" "823.7" "835.3" "829.8" "927.1" "825.8" "849.8" "" "" "" "" "" "" "" "" "" "" "765.6" "691.8" "647.5" "569.9" "687.1" "713.0" "703.9" "670.9" "557.0" "849.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7405730642826192701" "False" "High" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "0.000" "False" "36.936" "16" "7" "12" "7" "522" "56.2" "8.50" "36.04" "7" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "11" "0" "1.049" "1.073" "0.960" "1.001" "1.100" "1.023" "1.011" "1.073" "0.746" "774.4" "812.6" "831.1" "743.2" "775.2" "851.9" "792.4" "783.1" "830.7" "577.6" "" "" "" "" "" "" "" "" "" "" "699.1" "626.8" "642.8" "500.4" "646.7" "727.1" "672.2" "566.8" "560.3" "577.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6313231503744566384" "False" "High" "IsMasterProtein" "O00754" "Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3" "0.000" "False" "36.927" "9" "10" "12" "10" "1011" "113.7" "7.28" "37.20" "10" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf21260" "4125" "ENSG00000104774" "MAN2B1" "G5E928; hsa:4125; O00754; O15330; Q16680; Q93094; Q9BW13" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "" "2" "0" "0.989" "1.036" "0.982" "0.963" "1.117" "1.088" "1.082" "1.021" "0.760" "775.7" "767.5" "803.7" "761.4" "747.3" "866.4" "844.2" "839.0" "791.8" "589.6" "" "" "" "" "" "" "" "" "" "" "700.2" "592.0" "621.6" "512.7" "623.4" "739.5" "716.1" "607.2" "534.1" "589.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9134021061211319467" "False" "High" "IsMasterProtein" "Q9HA77" "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" "0.000" "False" "36.883" "15" "8" "12" "8" "564" "62.2" "8.34" "38.93" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01406" "79587" "ENSG00000134905" "CARS2" "hsa:79587; Q8NI84; Q96IV4; Q9HA77" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.068" "0.993" "0.971" "1.063" "1.043" "1.117" "1.079" "1.016" "0.655" "961.6" "1027.1" "954.9" "933.7" "1022.3" "1003.4" "1074.3" "1037.7" "976.9" "630.1" "" "" "" "" "" "" "" "" "" "" "868.0" "792.3" "738.5" "628.7" "852.8" "856.4" "911.3" "751.0" "658.9" "630.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5309458315612800198" "False" "High" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "0.000" "False" "36.817" "12" "7" "11" "7" "669" "72.4" "8.34" "36.18" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "1.004" "0.870" "1.093" "1.108" "0.822" "1.054" "1.078" "0.943" "0.867" "440.8" "442.8" "383.3" "482.0" "488.3" "362.2" "464.8" "475.1" "415.9" "382.3" "" "" "" "" "" "" "" "" "" "" "397.9" "341.5" "296.5" "324.6" "407.4" "309.1" "394.3" "343.8" "280.5" "382.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5894079024390586831" "False" "High" "IsMasterProtein" "Q9NQ29" "Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1" "0.000" "False" "36.811" "14" "5" "8" "4" "371" "43.7" "9.92" "29.10" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "55692" "ENSG00000007392" "LUC7L" "B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.977" "1.167" "1.004" "1.033" "1.109" "1.006" "0.941" "1.089" "0.945" "493.4" "481.9" "575.7" "495.3" "509.9" "547.0" "496.5" "464.5" "537.3" "466.1" "" "" "" "" "" "" "" "" "" "" "445.4" "371.7" "445.3" "333.6" "425.3" "466.9" "421.2" "336.1" "362.4" "466.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3281625266906913156" "False" "High" "IsMasterProtein" "Q7RTP6" "[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2" "0.000" "False" "36.758" "4" "8" "10" "8" "2002" "224.2" "5.55" "29.54" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "57553" "ENSG00000243156" "MICAL3" "B2RXJ5; E9PEF0; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3" "" "" "0" "0" "0.994" "1.035" "1.031" "0.954" "0.992" "1.044" "1.005" "1.077" "1.234" "364.5" "362.4" "377.3" "375.8" "347.8" "361.7" "380.4" "366.1" "392.5" "449.9" "" "" "" "" "" "" "" "" "" "" "329.0" "279.6" "291.8" "253.1" "290.1" "308.7" "322.7" "265.0" "264.7" "449.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115574768027660471" "False" "High" "IsMasterProtein" "P30837" "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=4" "0.000" "False" "36.748" "16" "9" "15" "8" "517" "57.2" "6.99" "42.51" "9" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00171" "219" "ENSG00000137124" "ALDH1B1" "B2R8F0; hsa:219; P30837; Q8WX76; Q9BV45" "Mitochondrial protein degradation; Ethanol oxidation" "" "2" "1" "0.934" "0.860" "0.980" "0.965" "0.880" "0.994" "0.961" "0.876" "0.632" "1231.3" "1149.9" "1059.3" "1206.6" "1187.8" "1084.0" "1224.4" "1183.1" "1078.4" "778.4" "" "" "" "" "" "" "" "" "" "" "1111.5" "887.0" "819.3" "812.5" "990.8" "925.2" "1038.6" "856.2" "727.3" "778.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-327475496585371320" "False" "High" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "0.000" "False" "36.726" "16" "6" "13" "6" "397" "41.3" "6.92" "45.51" "6" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Cholesterol biosynthesis" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "6" "0" "1.003" "1.091" "1.022" "1.004" "1.046" "1.043" "1.088" "1.094" "0.725" "1168.1" "1171.5" "1273.8" "1193.7" "1173.0" "1221.7" "1218.5" "1271.3" "1277.7" "847.0" "" "" "" "" "" "" "" "" "" "" "1054.4" "903.7" "985.2" "803.8" "978.5" "1042.7" "1033.6" "920.0" "861.8" "847.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4440624783436864340" "False" "High" "IsMasterProtein" "P01911" "HLA class II histocompatibility antigen, DRB1 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" "0.000" "False" "36.699" "29" "6" "15" "4" "266" "29.9" "7.74" "49.91" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00969, Pf07654" "3123" "ENSG00000196126" "HLA-DRB1" "A0MWF2; A0N0W1; A2ICT1; A2TGX3; A4F5N0; A4ZXA5; A4ZXA6; A4ZY86; A5H000; A5HKN8; A7DZP9; A7LA26; A7UHG2; A7X5B1; A7X5B7; A7X5E0; A7X5E6; A7X5H8; A7X5J4; A7X5K7; A8K098; A8YQE9; A9JPG0; B0BK85; B0LUZ6; B0UYW1; B1GWE7; B2CR03; B2LVF9; B2NJ29; B2ZCY1; B3VTP8; B3VTQ3; B5A8Y2; B5A8Y3; B5B8U0; B5B9V5; B5B9V6; B5LZ25; B5QSK8; B6VCX2; B6VEL9; B7UDB2; B9VRA4; B9X248; C0LAB5; hsa:3123; O02876; O02930; O19585; O19717; O19718; O19739; O19788; O46699; O46793; O46872; O62869; O62889; O77969; O78047; O78210; O98212; P01911; P01912; P01914; P04229; P13758; P13759; P13760; P13761; P20039; P79545; Q06662; Q0PGR5; Q0PQ39; Q14280; Q14QT2; Q155F7; Q19AF2; Q19K86; Q1AP33; Q1G0Z9; Q1JRP3; Q1KLJ6; Q27PR6; Q27PR7; Q29673; Q29720; Q29722; Q29734; Q29770; Q29771; Q29772; Q29790; Q29792; Q29800; Q29806; Q29833; Q29874; Q29875; Q29886; Q29968; Q29974; Q29975; Q2A120; Q2HZE5; Q2L9H4; Q2LE76; Q2MF40; Q2MJA6; Q2MZ92; Q2VQU1; Q2YHQ2; Q30006; Q30108; Q30112; Q30115; Q30116; Q30117; Q30120; Q30134; Q30142; Q30145; Q30149; Q30159; Q30166; Q30167; Q30200; Q307W5; Q31636; Q32MY7; Q3HUP9; Q3KTM1; Q3LA84; Q3LA87; Q3LA88; Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3LA93; Q3LA94; Q3LA95; Q3LA96; Q3LA97; Q3LA98; Q3LA99; Q3LAA0; Q3LAA1; Q3LAA2; Q3MQ60; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7; Q53IG1; Q56FN9; Q56FP1; Q56FP2; Q56FP3; Q58F52; Q5BM92; Q5EER6; Q5K3W2; Q5NDB9; Q5U9W6; Q5UBA2; Q5UT58; Q5W3L4; Q5Y7A7; Q5Y7B0; Q5Y7B9; Q5Y7E9; Q5Y7G0; Q683P7; Q6REE2; Q6T865; Q6U387; Q701T1; Q70GL2; Q70Q85; Q768U2; Q768U4; Q7M2H4; Q7YNY9; Q7YP03; Q7YP04; Q7YQ26; Q7YQA3; Q7YQA5; Q860D8; Q860D9; Q860E5; Q860H8; Q860S0; Q860Z3; Q861G6; Q861H0; Q861H4; Q861H5; Q861H7; Q861H8; Q8HWQ6; Q8MH59; Q8MH60; Q8WLU3; Q8WMA0; Q95348; Q95383; Q95389; Q95461; Q95HK1; Q95HL0; Q95HL1; Q95IE3; Q95IG2; Q95IT6; Q96HZ9; Q9BCL7; Q9BCP0; Q9BCP1; Q9BCP2; Q9BCP5; Q9BD21; Q9BD33; Q9BD40; Q9GIK5; Q9GIL5; Q9GIL6; Q9GIP3; Q9GIX8; Q9GIX9; Q9GIY0; Q9GIY1; Q9GIY2; Q9GIY3; Q9GIY4; Q9GJ25; Q9GJ56; Q9GJ57; Q9GJ58; Q9GJ60; Q9GJF8; Q9GJF9; Q9GJG0; Q9MXZ0; Q9MXZ5; Q9MY13; Q9MY45; Q9MY56; Q9MYF5; Q9TPB6; Q9TPW1; Q9TPW3; Q9TPW9; Q9TPX4; Q9TQ37; Q9TQ91; Q9TQE0; Q9UBY1; Q9UIM9; Q9UIN0; Q9XRX1; Q9XRY4; Q9XRY5; Q9Y453; Q9Y4H7" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; Primary ovarian insufficiency" "17" "1" "1.028" "1.116" "1.020" "0.983" "1.127" "0.982" "1.038" "1.103" "0.707" "1062.3" "1091.5" "1185.4" "1083.9" "1043.9" "1196.7" "1043.6" "1102.4" "1171.2" "751.4" "" "" "" "" "" "" "" "" "" "" "958.9" "842.0" "916.8" "729.9" "870.8" "1021.4" "885.3" "797.8" "789.9" "751.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4163681238843766636" "False" "High" "IsMasterProtein" "Q13144" "Translation initiation factor eIF2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "0.000" "False" "36.694" "12" "6" "9" "6" "721" "80.3" "5.08" "32.63" "6" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Recycling of eIF2:GDP" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "5" "0" "0.965" "0.814" "0.960" "0.929" "0.841" "1.038" "0.973" "0.883" "0.803" "363.2" "350.5" "295.8" "348.8" "337.4" "305.4" "376.9" "353.2" "320.8" "291.5" "" "" "" "" "" "" "" "" "" "" "327.8" "270.4" "228.8" "234.9" "281.5" "260.7" "319.7" "255.6" "216.4" "291.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3931502688338012469" "False" "High" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "0.000" "False" "36.624" "25" "8" "9" "8" "363" "39.7" "8.02" "31.13" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "0.998" "0.753" "1.044" "1.076" "0.771" "1.073" "1.109" "0.755" "0.824" "376.1" "375.5" "283.1" "392.8" "404.8" "290.2" "403.5" "417.1" "283.8" "309.9" "" "" "" "" "" "" "" "" "" "" "339.5" "289.6" "219.0" "264.5" "337.6" "247.7" "342.3" "301.8" "191.4" "309.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984641138409737976" "False" "High" "IsMasterProtein" "Q9BXK5" "Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1" "0.000" "False" "36.606" "14" "5" "8" "5" "485" "52.7" "4.44" "29.94" "5" "other biological processes" "other membranes;mitochondrion;nucleus" "enzyme regulator activity" "Pf00452" "23786" "ENSG00000099968" "BCL2L13" "B3KPE7; hsa:23786; Q96B37; Q96IB7; Q9BXK5; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3" "" "Regulation of apoptosis by parathyroid hormone-related protein; TAR syndrome" "2" "0" "0.959" "0.947" "0.996" "0.905" "0.947" "0.994" "0.942" "0.939" "1.015" "430.0" "412.1" "407.2" "428.1" "388.9" "407.1" "427.4" "404.9" "403.7" "436.2" "" "" "" "" "" "" "" "" "" "" "388.1" "317.9" "315.0" "288.3" "324.4" "347.5" "362.5" "293.0" "272.3" "436.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8417991388953307590" "False" "High" "IsMasterProtein" "O75064" "DENN domain-containing protein 4B OS=Homo sapiens OX=9606 GN=DENND4B PE=1 SV=4" "0.000" "False" "36.540" "7" "11" "14" "11" "1496" "163.7" "7.21" "40.47" "11" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "9909" "ENSG00000198837" "DENND4B" "hsa:9909; O75064; Q5T4K0" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.999" "0.867" "1.003" "0.995" "0.845" "0.957" "0.966" "0.879" "1.034" "432.3" "431.7" "374.8" "433.7" "430.0" "365.4" "413.7" "417.5" "379.9" "447.0" "" "" "" "" "" "" "" "" "" "" "390.2" "333.0" "289.9" "292.1" "358.7" "311.9" "350.9" "302.1" "256.3" "447.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6456635449604072928" "False" "High" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "0.000" "False" "36.520" "17" "7" "12" "7" "496" "56.8" "7.80" "36.36" "7" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "" "3" "0" "1.064" "0.998" "0.966" "1.003" "0.995" "1.010" "0.947" "0.995" "0.815" "672.3" "715.4" "670.6" "649.2" "674.1" "668.8" "678.9" "636.5" "669.2" "547.7" "" "" "" "" "" "" "" "" "" "" "606.8" "551.9" "518.7" "437.2" "562.3" "570.9" "575.9" "460.6" "451.4" "547.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6282846472165231546" "False" "High" "IsMasterProtein" "Q9P289" "Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2" "0.000" "False" "36.519" "19" "7" "10" "3" "416" "46.5" "5.29" "29.69" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "51765" "ENSG00000134602" "STK26" "B2RAU2; hsa:51765; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4; Q9P289" "Apoptotic cleavage of cellular proteins" "" "1" "1" "0.937" "0.760" "0.910" "1.074" "0.896" "0.982" "0.976" "0.877" "1.308" "306.9" "287.5" "233.1" "279.1" "329.7" "274.9" "301.3" "299.5" "269.2" "401.2" "" "" "" "" "" "" "" "" "" "" "277.0" "221.8" "180.3" "187.9" "275.0" "234.6" "255.6" "216.8" "181.6" "401.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4576818443980197018" "False" "High" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "0.000" "False" "36.509" "12" "5" "8" "5" "529" "57.8" "5.40" "29.96" "5" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "" "8" "0" "1.083" "1.060" "1.131" "0.931" "1.180" "0.993" "0.833" "1.157" "3.843" "105.0" "113.7" "111.3" "118.8" "97.8" "123.9" "104.3" "87.4" "121.5" "403.5" "" "" "" "" "" "" "" "" "" "" "94.8" "87.7" "86.1" "80.0" "81.6" "105.8" "88.5" "63.3" "81.9" "403.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4481377694352566724" "False" "High" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "0.000" "False" "36.423" "19" "8" "15" "8" "316" "35.8" "6.98" "49.04" "8" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Pregnenolone biosynthesis; Fructose biosynthesis" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Omega-6-fatty acids in senescence; Polyol pathway; Metapathway biotransformation Phase I and II" "7" "0" "1.005" "0.986" "0.990" "1.026" "1.029" "1.090" "1.048" "1.043" "0.788" "750.3" "754.3" "739.9" "742.5" "769.7" "771.9" "817.6" "786.1" "782.4" "591.4" "" "" "" "" "" "" "" "" "" "" "677.3" "581.8" "572.3" "500.0" "642.0" "658.8" "693.5" "568.9" "527.7" "591.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3853404113387134869" "False" "High" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "0.000" "False" "36.376" "16" "6" "10" "6" "544" "61.5" "5.47" "26.84" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "1.105" "0.997" "1.095" "1.083" "1.055" "1.035" "1.011" "1.028" "0.787" "237.5" "262.4" "236.7" "259.9" "257.1" "250.5" "245.9" "240.0" "244.0" "186.8" "" "" "" "" "" "" "" "" "" "" "214.4" "202.4" "183.1" "175.0" "214.5" "213.8" "208.6" "173.7" "164.6" "186.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8722067118007621165" "False" "High" "IsMasterProtein" "P23497" "Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3" "0.000" "False" "36.288" "10" "8" "10" "8" "879" "100.4" "8.22" "31.27" "8" "cell organization and biogenesis;DNA metabolism;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01342, Pf03172, Pf09011" "6672" "ENSG00000067066" "SP100" "B4DDX5; B8ZZD8; E7EUA7; E9PH61; F8WFE2; hsa:6672; O75450; P23497; Q13343; Q8TE34; Q96F70; Q96T24; Q96T95; Q9NP33; Q9UE32" "SUMOylation of DNA damage response and repair proteins; Interferon gamma signaling" "" "2" "0" "1.003" "0.907" "1.066" "1.055" "0.866" "1.054" "1.125" "0.882" "0.932" "363.9" "365.1" "330.2" "388.0" "384.0" "315.1" "383.5" "409.3" "320.8" "339.2" "" "" "" "" "" "" "" "" "" "" "328.5" "281.6" "255.4" "261.3" "320.3" "269.0" "325.3" "296.2" "216.4" "339.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5573566891233996467" "False" "High" "IsMasterProtein" "Q96FV2" "Secernin-2 OS=Homo sapiens OX=9606 GN=SCRN2 PE=1 SV=3" "0.000" "False" "36.244" "17" "6" "8" "6" "425" "46.6" "5.67" "27.42" "6" "protein metabolism" "" "other molecular function" "Pf03577" "90507" "ENSG00000141295" "SCRN2" "A8K3N1; B7Z8S7; E9PBV5; hsa:90507; Q96AC3; Q96FV2; Q9BU04" "" "" "0" "0" "1.139" "1.153" "1.035" "1.017" "1.128" "1.028" "1.217" "1.120" "1.049" "85.7" "97.6" "98.8" "88.7" "87.1" "96.7" "88.1" "104.3" "95.9" "89.9" "" "" "" "" "" "" "" "" "" "" "77.4" "75.3" "76.4" "59.7" "72.7" "82.5" "74.7" "75.5" "64.7" "89.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8127348192762311520" "False" "High" "IsMasterProtein" "Q96HN2" "Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1" "0.000" "False" "36.222" "13" "7" "12" "2" "611" "66.7" "7.36" "37.18" "7" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00670, Pf05221" "23382" "ENSG00000158467" "AHCYL2" "B4DIZ5; D9N155; hsa:23382; O94917; Q96HN2" "Bicarbonate transporters" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Spina bifida" "4" "0" "1.003" "0.763" "0.971" "0.993" "0.880" "1.065" "1.003" "0.881" "0.736" "89.4" "89.8" "68.2" "86.9" "88.8" "78.7" "95.2" "89.7" "78.8" "65.8" "" "" "" "" "" "" "" "" "" "" "80.7" "69.2" "52.8" "58.5" "74.1" "67.2" "80.8" "64.9" "53.1" "65.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2120449807322374936" "False" "High" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "0.000" "False" "36.188" "18" "6" "8" "6" "365" "41.0" "5.16" "25.62" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "Nucleotide-binding oligomerization domain (NOD) pathway" "3" "0" "0.911" "0.757" "0.921" "0.968" "0.901" "0.929" "0.965" "0.928" "1.148" "396.1" "360.9" "299.8" "364.9" "383.5" "356.7" "367.9" "382.3" "367.5" "454.7" "" "" "" "" "" "" "" "" "" "" "357.5" "278.4" "231.8" "245.8" "319.9" "304.5" "312.1" "276.6" "247.8" "454.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "598569642609282214" "False" "High" "IsMasterProtein" "Q9BRS2" "Serine/threonine-protein kinase RIO1 OS=Homo sapiens OX=9606 GN=RIOK1 PE=1 SV=2" "0.000" "False" "36.175" "16" "8" "12" "8" "568" "65.5" "6.19" "30.02" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163" "83732" "ENSG00000124784" "RIOK1" "B2RB28; Q8NDC8; Q96NV9; Q9BRS2" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.016" "0.701" "0.998" "0.962" "0.727" "1.022" "0.964" "0.756" "0.864" "626.2" "636.3" "438.9" "624.9" "602.4" "455.4" "640.3" "603.6" "473.2" "541.0" "" "" "" "" "" "" "" "" "" "" "565.2" "490.8" "339.4" "420.8" "502.5" "388.7" "543.1" "436.8" "319.2" "541.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1018884242771776576" "False" "High" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "0.000" "False" "36.172" "16" "4" "19" "4" "256" "27.7" "7.78" "60.00" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Detoxification of Reactive Oxygen Species" "Selenium micronutrient network" "2" "0" "0.971" "1.067" "0.885" "1.010" "1.231" "0.955" "1.022" "1.059" "0.800" "421.0" "408.6" "449.3" "372.7" "425.0" "518.3" "402.1" "430.2" "445.9" "336.8" "" "" "" "" "" "" "" "" "" "" "380.0" "315.2" "347.5" "251.0" "354.6" "442.4" "341.1" "311.4" "300.8" "336.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020319621841403457" "False" "High" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "0.000" "False" "36.170" "42" "7" "21" "7" "180" "19.6" "6.02" "56.92" "7" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "" "3" "0" "1.024" "0.971" "0.993" "1.005" "0.994" "1.002" "1.014" "0.959" "0.696" "1035.7" "1060.9" "1006.1" "1028.5" "1041.4" "1029.2" "1037.9" "1050.5" "993.6" "720.8" "" "" "" "" "" "" "" "" "" "" "934.9" "818.3" "778.2" "692.6" "868.7" "878.4" "880.4" "760.2" "670.2" "720.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198738028437086806" "False" "High" "IsMasterProtein" "Q7Z2W4" "Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3" "0.000" "False" "36.101" "7" "5" "7" "5" "902" "101.4" "8.40" "22.62" "5" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf02825, Pf18606, Pf18633" "56829" "ENSG00000105939" "ZC3HAV1" "A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "1.008" "1.073" "1.059" "1.013" "1.138" "0.925" "0.884" "1.231" "2.250" "348.9" "351.5" "374.5" "369.3" "353.6" "397.0" "322.9" "308.5" "429.3" "784.9" "" "" "" "" "" "" "" "" "" "" "314.9" "271.2" "289.7" "248.7" "295.0" "338.9" "273.9" "223.2" "289.6" "784.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5594688980084840223" "False" "High" "IsMasterProtein" "Q63HN8" "E3 ubiquitin-protein ligase RNF213 OS=Homo sapiens OX=9606 GN=RNF213 PE=1 SV=3" "0.000" "False" "36.085" "2" "11" "12" "10" "5207" "591.0" "6.48" "35.34" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf20173" "57674" "ENSG00000173821" "RNF213" "C9JCP4; D6RI12; F8WKS1; hsa:57674; Q63HN8; Q658P6; Q69YK7; Q6MZR1; Q8IWF4; Q8IZX1; Q8IZX2; Q8N406; Q8TEU0; Q9H6C9; Q9H6H9; Q9H6P3; Q9H8A9; Q9HCF4; Q9HCL8" "Antigen processing: Ubiquitination & Proteasome degradation; Signaling by ALK fusions and activated point mutants; Suppression of apoptosis" "" "3" "0" "0.952" "1.495" "0.988" "0.979" "1.411" "1.026" "0.897" "1.468" "2.814" "327.3" "311.5" "489.2" "323.3" "320.4" "461.7" "335.8" "293.5" "480.4" "921.1" "" "" "" "" "" "" "" "" "" "" "295.4" "240.3" "378.3" "217.7" "267.3" "394.1" "284.8" "212.4" "324.0" "921.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4764020307768204184" "False" "High" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "0.000" "False" "36.049" "24" "4" "19" "4" "193" "21.8" "6.10" "51.13" "4" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; VEGFA-VEGFR2 Pathway; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; GNAQ pathways in port-wine stain; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "71" "0" "0.979" "1.047" "1.068" "1.041" "1.011" "1.047" "0.940" "1.004" "0.760" "761.1" "745.0" "797.1" "812.7" "792.5" "769.7" "797.0" "715.6" "764.5" "578.4" "" "" "" "" "" "" "" "" "" "" "687.0" "574.6" "616.5" "547.3" "661.0" "656.9" "676.1" "517.9" "515.7" "578.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190744193783032342" "False" "High" "IsMasterProtein" "Q92619" "Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2" "0.000" "False" "35.999" "6" "7" "9" "7" "1136" "124.5" "6.10" "29.93" "7" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "23526" "ENSG00000180448" "ARHGAP45" "B4DTS4; F6QP70; hsa:23526; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q92619; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24" "Neutrophil degranulation; RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "" "4" "0" "1.049" "0.832" "1.069" "1.096" "0.821" "1.065" "1.026" "0.858" "1.033" "363.1" "381.0" "302.1" "388.1" "398.0" "298.0" "386.6" "372.4" "311.5" "375.1" "" "" "" "" "" "" "" "" "" "" "327.8" "293.9" "233.7" "261.3" "332.0" "254.3" "327.9" "269.5" "210.1" "375.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4204109305997435954" "False" "High" "IsMasterProtein" "Q07960" "Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1" "0.000" "False" "35.989" "22" "8" "9" "8" "439" "50.4" "6.29" "31.12" "8" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf13716" "392" "ENSG00000175220" "ARHGAP1" "D3DQQ6; hsa:392; Q07960" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RND2 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle" "" "13" "0" "1.003" "1.125" "0.976" "0.995" "1.136" "1.027" "0.879" "0.991" "1.021" "236.3" "237.1" "265.9" "230.7" "235.2" "268.4" "242.7" "207.7" "234.2" "241.2" "" "" "" "" "" "" "" "" "" "" "213.3" "182.8" "205.7" "155.3" "196.2" "229.1" "205.9" "150.3" "158.0" "241.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "57787487465406304" "False" "High" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "0.000" "False" "35.956" "11" "6" "8" "6" "709" "81.0" "6.87" "27.22" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292, Pf21092, Pf21103" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "" "12" "0" "1.083" "3.220" "1.105" "1.133" "3.260" "1.172" "1.071" "2.891" "1.493" "242.4" "262.5" "780.5" "267.9" "274.7" "790.1" "284.0" "259.6" "700.8" "361.9" "" "" "" "" "" "" "" "" "" "" "218.8" "202.5" "603.6" "180.4" "229.1" "674.4" "240.9" "187.9" "472.7" "361.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144155955974209704" "False" "High" "IsMasterProtein" "P16220" "Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=3" "0.000" "False" "35.943" "20" "5" "9" "3" "327" "35.1" "5.27" "29.88" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "1385" "ENSG00000118260" "CREB1" "hsa:1385; P16220; P21934; Q6V963; Q9UMA7" "ADORA2B mediated anti-inflammatory cytokines production; FCGR3A-mediated IL10 synthesis; HCMV Early Events; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription of neuronal ligands; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Regulation of MECP2 expression and activity; Transcriptional regulation of granulopoiesis; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK; NOTCH2 intracellular domain regulates transcription; MECP2 regulates neuronal receptors and channels; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of Adenylate Cyclase; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; PKA-mediated phosphorylation of CREB; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling; MECP2 regulates transcription factors" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Energy metabolism; miRNAs involved in DNA damage response; Folate-alcohol and cancer pathway hypotheses; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Ovarian infertility; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB signaling; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; p38 MAPK signaling pathway; NO/cGMP/PKG mediated neuroprotection; White fat cell differentiation; PI3K-Akt signaling pathway; Phosphodiesterases in neuronal function; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; G1 to S cell cycle control; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Hepatitis B infection; Melanoma; mBDNF and proBDNF regulation of GABA neurotransmission; CAMKK2 pathway; GPR143 in melanocytes and retinal pigment epithelium cells; Galanin receptor pathway; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Rubinstein-Taybi syndrome 1; Smith-Magenis and Potocki-Lupski syndrome copy number variation; Interferon type I signaling pathways; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "85" "1" "1.027" "0.834" "0.960" "0.941" "0.831" "0.996" "0.940" "0.889" "0.712" "264.9" "272.0" "220.9" "254.3" "249.3" "220.1" "263.9" "249.0" "235.6" "188.7" "" "" "" "" "" "" "" "" "" "" "239.2" "209.8" "170.9" "171.3" "208.0" "187.8" "223.9" "180.2" "158.9" "188.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844416647535235754" "False" "High" "IsMasterProtein" "O00233" "26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3" "0.000" "False" "35.933" "30" "6" "14" "6" "223" "24.7" "6.95" "47.38" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf17820, Pf18265" "5715" "ENSG00000110801" "PSMD9" "B2RD35; G3V1Q6; hsa:5715; O00233; Q9BQ42" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "63" "0" "0.949" "0.924" "0.974" "0.988" "0.898" "1.006" "1.002" "0.963" "0.762" "897.0" "851.7" "829.2" "873.3" "886.1" "805.5" "902.3" "898.8" "863.4" "683.4" "" "" "" "" "" "" "" "" "" "" "809.7" "656.9" "641.3" "588.0" "739.2" "687.5" "765.4" "650.4" "582.4" "683.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4793391525152750587" "False" "High" "IsMasterProtein" "P61020" "Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1" "0.000" "False" "35.868" "29" "5" "12" "2" "215" "23.7" "8.13" "33.52" "5" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5869" "ENSG00000111540" "RAB5B" "A8K982; B4DKD7; hsa:5869; P35239; P35277; P61020; Q6PIK9; Q86TH0; Q8IXL2" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "9" "0" "1.021" "1.073" "1.194" "1.068" "1.000" "1.045" "1.026" "1.013" "0.884" "211.3" "215.8" "226.8" "252.2" "225.7" "211.3" "220.8" "216.9" "214.2" "186.8" "" "" "" "" "" "" "" "" "" "" "190.7" "166.5" "175.4" "169.9" "188.3" "180.3" "187.3" "157.0" "144.4" "186.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272121550069660062" "False" "High" "IsMasterProtein" "P35268" "Large ribosomal subunit protein eL22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "0.000" "False" "35.792" "30" "3" "9" "3" "128" "14.8" "9.19" "29.88" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "Major pathway of rRNA processing in the nucleolus and cytosol; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.979" "1.145" "1.005" "1.037" "1.058" "0.965" "1.068" "1.125" "0.356" "256.9" "251.6" "294.2" "258.3" "266.4" "271.7" "247.8" "274.3" "288.9" "91.5" "" "" "" "" "" "" "" "" "" "" "231.9" "194.0" "227.6" "173.9" "222.2" "231.9" "210.2" "198.5" "194.9" "91.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-996241339141020167" "False" "High" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "0.000" "False" "35.789" "8" "7" "7" "7" "1091" "126.2" "6.99" "26.60" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13476" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "1.128" "0.919" "1.060" "1.043" "0.866" "1.009" "0.871" "0.926" "1.091" "421.7" "475.6" "387.6" "447.2" "439.6" "365.3" "425.6" "367.3" "390.6" "460.1" "" "" "" "" "" "" "" "" "" "" "380.6" "366.8" "299.8" "301.1" "366.7" "311.8" "361.0" "265.8" "263.4" "460.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4414098033661647234" "False" "High" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "0.000" "False" "35.781" "26" "8" "12" "8" "359" "39.6" "7.17" "28.92" "8" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin activation and detoxification" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "3" "0" "1.084" "1.104" "0.784" "1.054" "1.028" "1.117" "1.078" "1.048" "0.897" "386.4" "418.9" "426.7" "303.0" "407.4" "397.1" "431.7" "416.6" "405.0" "346.5" "" "" "" "" "" "" "" "" "" "" "348.8" "323.1" "330.0" "204.0" "339.8" "338.9" "366.2" "301.5" "273.2" "346.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3647234260862617095" "False" "High" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "0.000" "False" "35.778" "25" "5" "14" "5" "209" "23.4" "8.24" "37.84" "5" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "1.019" "1.354" "0.951" "1.241" "1.122" "1.324" "1.095" "1.185" "0.616" "605.2" "616.7" "819.6" "575.4" "750.9" "679.2" "801.2" "662.5" "717.1" "372.6" "" "" "" "" "" "" "" "" "" "" "546.3" "475.7" "633.9" "387.5" "626.4" "579.7" "679.6" "479.5" "483.7" "372.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184402302268645522" "False" "High" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "0.000" "False" "35.773" "11" "12" "14" "12" "1037" "117.3" "6.92" "42.68" "12" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "Mitochondrial protein import" "" "1" "0" "1.088" "1.484" "1.136" "1.014" "1.440" "1.142" "0.968" "1.396" "1.559" "250.9" "273.0" "372.5" "285.0" "254.5" "361.4" "286.7" "242.9" "350.4" "391.2" "" "" "" "" "" "" "" "" "" "" "226.5" "210.6" "288.1" "191.9" "212.3" "308.5" "243.2" "175.8" "236.3" "391.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079074271338885879" "False" "High" "IsMasterProtein" "P16403" "Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2" "0.000" "False" "35.760" "26" "6" "11" "1" "213" "21.4" "10.93" "35.97" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3006" "ENSG00000187837" "H1-2" "A8K4I2; hsa:3006; P16403" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8736083768290238180" "False" "High" "IsMasterProtein" "Cont_P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "0.000" "True" "35.758" "15" "10" "13" "6" "590" "62.3" "7.74" "39.71" "10" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "Formation of the cornified envelope; Type I hemidesmosome assembly" "" "3" "1" "0.970" "1.468" "1.244" "0.580" "0.792" "0.644" "0.968" "0.789" "0.706" "549.3" "532.6" "806.1" "683.5" "318.5" "435.2" "353.6" "531.7" "433.2" "388.0" "" "" "" "" "" "" "" "" "" "" "495.8" "410.8" "623.5" "460.3" "265.7" "371.4" "300.0" "384.8" "292.2" "388.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9177231757861531522" "False" "High" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "0.000" "False" "35.756" "24" "8" "9" "7" "340" "38.0" "8.63" "30.27" "8" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "Nuclear receptors meta-pathway; NRF2 pathway" "7" "1" "1.027" "1.046" "0.999" "1.045" "1.050" "1.031" "0.886" "1.082" "2.692" "661.4" "679.1" "691.8" "660.5" "691.5" "694.3" "681.7" "585.9" "715.6" "1780.5" "" "" "" "" "" "" "" "" "" "" "597.1" "523.8" "535.1" "444.8" "576.8" "592.6" "578.3" "424.0" "482.7" "1780.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043086942307680796" "False" "High" "IsMasterProtein" "P63220" "Small ribosomal subunit protein eS21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "0.000" "False" "35.753" "48" "4" "15" "4" "83" "9.1" "8.50" "45.39" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.962" "1.160" "1.039" "1.037" "1.084" "1.056" "1.114" "1.142" "0.638" "1228.9" "1182.6" "1425.6" "1277.2" "1274.8" "1332.5" "1298.1" "1369.4" "1403.6" "784.3" "" "" "" "" "" "" "" "" "" "" "1109.3" "912.2" "1102.6" "860.0" "1063.4" "1137.3" "1101.2" "991.0" "946.7" "784.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3313635736816900772" "False" "High" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "0.000" "False" "35.722" "17" "7" "11" "7" "429" "47.4" "5.60" "31.98" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "RMTs methylate histone arginines; UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; HATs acetylate histones; DNA Damage Recognition in GG-NER" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "10" "0" "1.035" "1.018" "0.970" "0.969" "0.885" "0.967" "0.900" "1.010" "1.215" "901.2" "932.9" "917.6" "874.5" "873.3" "797.3" "871.4" "811.2" "910.3" "1095.2" "" "" "" "" "" "" "" "" "" "" "813.5" "719.6" "709.7" "588.9" "728.5" "680.5" "739.2" "587.0" "614.0" "1095.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075280951894741873" "False" "High" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "0.000" "False" "35.704" "29" "3" "10" "3" "134" "15.3" "4.53" "35.70" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.011" "0.997" "1.151" "0.954" "1.036" "1.027" "1.097" "1.070" "0.733" "623.0" "630.0" "620.9" "717.3" "594.2" "645.6" "640.0" "683.4" "666.5" "456.6" "" "" "" "" "" "" "" "" "" "" "562.3" "485.9" "480.2" "483.0" "495.7" "551.1" "542.9" "494.6" "449.5" "456.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4306142825200876867" "False" "High" "IsMasterProtein" "P11766" "Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4" "0.000" "False" "35.700" "26" "10" "15" "10" "374" "39.7" "7.49" "45.38" "10" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00107, Pf08240" "128" "ENSG00000197894" "ADH5" "hsa:128; P11766; Q6FHR2" "Ethanol oxidation" "Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism" "3" "0" "1.049" "0.980" "1.134" "1.099" "1.048" "1.217" "1.118" "1.017" "0.784" "938.3" "984.3" "919.5" "1064.1" "1031.0" "983.3" "1142.0" "1048.6" "954.2" "736.0" "" "" "" "" "" "" "" "" "" "" "847.0" "759.2" "711.2" "716.6" "860.0" "839.3" "968.8" "758.9" "643.6" "736.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630318732500359632" "False" "High" "IsMasterProtein" "P62280" "Small ribosomal subunit protein uS17 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "0.000" "False" "35.648" "44" "8" "19" "8" "158" "18.4" "10.30" "47.82" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "21" "0" "0.906" "0.919" "0.895" "0.944" "0.890" "0.925" "0.938" "0.905" "0.519" "1666.1" "1509.4" "1531.6" "1490.4" "1572.7" "1483.3" "1540.6" "1563.1" "1507.2" "864.2" "" "" "" "" "" "" "" "" "" "" "1503.9" "1164.2" "1184.6" "1003.6" "1311.9" "1266.1" "1306.8" "1131.2" "1016.6" "864.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8106811875095759613" "False" "High" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "0.000" "False" "35.596" "22" "3" "30" "3" "111" "12.2" "3.78" "109.37" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.040" "0.768" "1.053" "0.978" "0.894" "0.975" "1.141" "0.846" "0.721" "3263.5" "3393.0" "2507.5" "3437.3" "3192.5" "2917.7" "3181.5" "3722.3" "2762.0" "2353.5" "" "" "" "" "" "" "" "" "" "" "2945.8" "2617.2" "1939.4" "2314.7" "2663.1" "2490.3" "2698.8" "2693.8" "1862.9" "2353.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2260332764015544813" "False" "High" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "0.000" "False" "35.586" "8" "9" "11" "9" "1192" "132.5" "6.19" "37.83" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "Post-chaperonin tubulin folding pathway" "" "1" "0" "1.089" "0.891" "1.034" "1.004" "0.999" "1.073" "0.949" "1.057" "1.431" "230.4" "251.0" "205.2" "238.2" "231.3" "230.2" "247.1" "218.6" "243.5" "329.7" "" "" "" "" "" "" "" "" "" "" "207.9" "193.6" "158.7" "160.4" "193.0" "196.5" "209.6" "158.2" "164.3" "329.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6956886752181187117" "False" "High" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "0.000" "False" "35.546" "27" "10" "13" "9" "364" "40.7" "8.88" "33.83" "10" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "Protein hydroxylation" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "1" "1.066" "0.908" "1.028" "1.036" "0.922" "1.062" "0.960" "0.958" "0.922" "794.1" "846.8" "721.0" "816.0" "822.4" "731.8" "843.3" "762.3" "760.9" "732.3" "" "" "" "" "" "" "" "" "" "" "716.8" "653.2" "557.6" "549.5" "686.0" "624.6" "715.3" "551.6" "513.2" "732.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6978617919950458725" "False" "High" "IsMasterProtein" "O43592" "Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2" "0.000" "False" "35.459" "10" "9" "11" "9" "962" "109.9" "5.39" "26.88" "9" "transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19282" "11260" "ENSG00000184575" "XPOT" "A6NLH1; hsa:11260; O43592; O43784; Q8WUG2; Q9BVS7" "tRNA processing in the nucleus" "" "1" "0" "1.103" "0.779" "0.963" "1.034" "0.987" "0.954" "0.857" "1.072" "2.713" "150.1" "165.6" "117.0" "144.5" "155.3" "148.1" "143.2" "128.7" "161.0" "407.3" "" "" "" "" "" "" "" "" "" "" "135.5" "127.7" "90.5" "97.3" "129.5" "126.4" "121.5" "93.1" "108.6" "407.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1468233501590493710" "False" "High" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "0.000" "False" "35.446" "16" "8" "10" "8" "514" "57.6" "9.42" "35.35" "8" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "1.012" "2.161" "1.019" "0.933" "2.083" "0.982" "0.906" "2.163" "1.109" "448.7" "454.1" "969.6" "457.3" "418.7" "934.5" "440.5" "406.4" "970.4" "497.7" "" "" "" "" "" "" "" "" "" "" "405.0" "350.3" "749.9" "307.9" "349.2" "797.6" "373.7" "294.1" "654.5" "497.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-105519067553436175" "False" "High" "IsMasterProtein" "Q04323" "UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2" "0.000" "False" "35.417" "21" "6" "10" "6" "297" "33.3" "5.25" "33.95" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00627, Pf00789" "51035" "ENSG00000162191" "UBXN1" "hsa:51035; Q04323; Q9BV93; Q9BVV5" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "2" "0" "0.964" "0.844" "1.117" "1.038" "0.854" "1.063" "1.041" "0.864" "1.362" "704.0" "678.8" "594.2" "786.1" "731.1" "601.0" "748.4" "733.2" "608.1" "958.5" "" "" "" "" "" "" "" "" "" "" "635.5" "523.6" "459.6" "529.4" "609.8" "513.0" "634.9" "530.6" "410.2" "958.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8291794919948140528" "False" "High" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "0.000" "False" "35.267" "7" "9" "11" "9" "1278" "141.6" "5.81" "34.85" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; XBP1(S) activates chaperone genes" "Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "8" "0" "0.972" "0.872" "1.035" "0.910" "0.829" "0.950" "0.827" "0.910" "2.519" "624.3" "606.7" "544.5" "646.0" "568.0" "517.6" "593.4" "516.1" "567.9" "1572.4" "" "" "" "" "" "" "" "" "" "" "563.5" "468.0" "421.2" "435.0" "473.8" "441.8" "503.3" "373.5" "383.0" "1572.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8219779968186532826" "False" "High" "IsMasterProtein" "Q9UI26" "Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1" "0.000" "False" "35.253" "9" "8" "9" "8" "975" "112.5" "5.25" "26.95" "8" "transport" "cytosol;nucleus" "other molecular function" "Pf03810" "51194" "ENSG00000086200" "IPO11" "A6NGJ5; B4DZ73; D3DW98; hsa:51194; Q8N5R2; Q9NSJ6; Q9NVB1; Q9UI26" "" "" "0" "0" "0.982" "0.844" "0.992" "0.934" "0.789" "1.017" "1.023" "0.892" "0.983" "494.1" "485.1" "417.3" "490.1" "461.5" "389.8" "502.6" "505.7" "440.8" "485.6" "" "" "" "" "" "" "" "" "" "" "446.0" "374.2" "322.7" "330.1" "385.0" "332.7" "426.3" "366.0" "297.3" "485.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "197200824509217859" "False" "High" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "0.000" "False" "35.241" "10" "5" "9" "5" "664" "72.6" "7.39" "29.24" "5" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "9" "0" "1.112" "0.950" "1.026" "1.019" "1.131" "0.985" "1.028" "1.151" "0.758" "140.2" "155.9" "133.2" "143.9" "142.8" "158.6" "138.1" "144.1" "161.4" "106.3" "" "" "" "" "" "" "" "" "" "" "126.6" "120.2" "103.0" "96.9" "119.2" "135.3" "117.1" "104.3" "108.8" "106.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6465314109903613014" "False" "High" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "0.000" "False" "35.152" "16" "8" "9" "8" "494" "56.4" "6.96" "31.65" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Regulation of HSF1-mediated heat shock response" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "4" "0" "0.990" "0.801" "0.885" "0.977" "0.795" "0.925" "0.772" "0.788" "3.674" "653.4" "647.2" "523.7" "578.4" "638.3" "519.1" "604.4" "504.7" "514.9" "2400.8" "" "" "" "" "" "" "" "" "" "" "589.8" "499.2" "405.0" "389.5" "532.5" "443.1" "512.7" "365.3" "347.3" "2400.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5639426559288223252" "False" "High" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "0.000" "False" "35.128" "32" "5" "9" "5" "172" "18.8" "5.69" "31.80" "5" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "1.047" "1.071" "0.923" "1.074" "1.202" "0.970" "1.083" "1.076" "0.754" "283.3" "296.6" "303.4" "261.5" "304.3" "340.4" "274.8" "306.8" "304.8" "213.7" "" "" "" "" "" "" "" "" "" "" "255.7" "228.8" "234.7" "176.1" "253.9" "290.5" "233.1" "222.0" "205.6" "213.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2943690132932996841" "False" "High" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "0.000" "False" "35.117" "26" "6" "10" "1" "219" "21.9" "11.03" "33.97" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Pathways affected in adenoid cystic carcinoma" "3" "3" "0.941" "0.682" "0.919" "0.974" "0.684" "1.036" "1.131" "0.672" "0.489" "505.8" "475.8" "344.7" "464.7" "492.8" "345.9" "524.1" "572.2" "340.0" "247.5" "" "" "" "" "" "" "" "" "" "" "456.6" "367.0" "266.6" "312.9" "411.0" "295.3" "444.6" "414.1" "229.3" "247.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951553745667677229" "False" "High" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "0.000" "False" "35.072" "15" "5" "7" "5" "397" "44.8" "7.08" "20.22" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; HDAC6 interactions in the central nervous system" "4" "0" "1.012" "0.899" "0.867" "0.950" "0.873" "0.973" "0.931" "0.870" "1.980" "95.2" "96.4" "85.6" "82.5" "90.5" "83.1" "92.7" "88.6" "82.8" "188.5" "" "" "" "" "" "" "" "" "" "" "86.0" "74.4" "66.2" "55.6" "75.5" "71.0" "78.6" "64.1" "55.9" "188.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047661720353379507" "False" "High" "IsMasterProtein" "Q03426" "Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1" "0.000" "False" "35.025" "14" "4" "9" "4" "396" "42.4" "6.46" "32.24" "4" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544" "4598" "ENSG00000110921" "MVK" "hsa:4598; Q03426" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "0.906" "0.775" "0.880" "0.913" "0.827" "1.001" "0.939" "0.725" "1.370" "682.8" "618.7" "529.4" "600.8" "623.3" "564.6" "683.2" "640.8" "494.9" "935.4" "" "" "" "" "" "" "" "" "" "" "616.3" "477.2" "409.4" "404.6" "520.0" "481.9" "579.5" "463.7" "333.8" "935.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585168671336988915" "False" "High" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=3" "0.000" "False" "35.022" "11" "9" "12" "8" "825" "94.8" "6.55" "38.36" "9" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "A0A5F9UK94; B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "Purine salvage" "" "1" "0" "1.043" "0.993" "1.077" "1.064" "0.932" "1.068" "1.105" "1.041" "0.822" "334.4" "348.7" "332.0" "360.3" "355.7" "311.7" "357.3" "369.5" "348.1" "274.8" "" "" "" "" "" "" "" "" "" "" "301.9" "269.0" "256.7" "242.6" "296.7" "266.0" "303.1" "267.4" "234.8" "274.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8769135798573244061" "False" "High" "IsMasterProtein" "P35658" "Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2" "0.000" "False" "35.005" "4" "8" "9" "8" "2090" "213.5" "7.47" "30.05" "8" "other metabolic processes;transport;other biological processes" "cytosol;nucleus" "other molecular function" "Pf18617" "8021" "ENSG00000126883" "NUP214" "A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3" "SUMOylation of DNA replication proteins; HCMV Early Events; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HuR (ELAVL1) binds and stabilizes mRNA" "TGF-beta signaling pathway" "30" "0" "0.939" "0.976" "0.918" "1.083" "1.013" "0.955" "0.964" "0.989" "1.336" "424.8" "399.1" "414.8" "390.0" "460.0" "430.2" "405.7" "409.4" "420.2" "567.6" "" "" "" "" "" "" "" "" "" "" "383.5" "307.8" "320.8" "262.6" "383.7" "367.2" "344.1" "296.3" "283.4" "567.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4746768512254432328" "False" "High" "IsMasterProtein" "Q9Y4X5" "E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2" "0.000" "False" "34.993" "11" "6" "9" "6" "557" "64.1" "5.08" "34.29" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf01485, Pf19422, Pf21235" "25820" "ENSG00000166233" "ARIH1" "B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5" "PKR-mediated signaling; RSV-host interactions; ISG15 antiviral mechanism" "" "3" "0" "0.891" "0.931" "0.897" "0.887" "1.027" "0.912" "0.923" "0.919" "0.741" "345.6" "307.9" "321.7" "309.9" "306.7" "355.1" "315.4" "318.9" "317.5" "256.1" "" "" "" "" "" "" "" "" "" "" "312.0" "237.5" "248.8" "208.7" "255.8" "303.1" "267.5" "230.8" "214.1" "256.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6735907081845110604" "False" "High" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "0.000" "False" "34.990" "10" "7" "8" "7" "958" "108.9" "7.14" "29.26" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "1.050" "0.977" "1.177" "1.148" "0.972" "1.132" "0.803" "0.953" "4.506" "221.5" "232.7" "216.3" "260.7" "254.3" "215.3" "250.8" "178.0" "211.1" "998.2" "" "" "" "" "" "" "" "" "" "" "200.0" "179.5" "167.3" "175.6" "212.2" "183.8" "212.8" "128.8" "142.4" "998.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260804329009372873" "False" "High" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "0.000" "False" "34.974" "7" "8" "11" "8" "1269" "144.7" "6.05" "31.12" "8" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00560, Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "" "VEGFA-VEGFR2 signaling; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "0.943" "0.911" "1.020" "1.051" "0.868" "1.018" "0.995" "0.896" "1.838" "399.0" "376.4" "363.6" "406.8" "419.2" "346.2" "406.0" "397.0" "357.5" "733.3" "" "" "" "" "" "" "" "" "" "" "360.1" "290.4" "281.2" "273.9" "349.7" "295.5" "344.4" "287.3" "241.1" "733.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7131720843867798084" "False" "High" "IsMasterProtein" "Q9BT09" "Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1" "0.000" "False" "34.942" "28" "7" "10" "7" "278" "30.7" "5.49" "32.08" "7" "stress response" "ER/Golgi" "signal transduction activity or receptor binding" "Pf11938" "10695" "ENSG00000137161" "CNPY3" "hsa:10695; O15412; Q0P6I2; Q8NF54; Q8WTU8; Q9BT09; Q9P0F2" "Trafficking and processing of endosomal TLR" "" "1" "0" "1.014" "1.010" "0.876" "0.957" "1.031" "0.977" "1.103" "0.965" "0.682" "747.7" "758.4" "754.9" "654.9" "715.8" "771.0" "730.5" "824.5" "721.8" "509.9" "" "" "" "" "" "" "" "" "" "" "675.0" "585.0" "583.9" "441.0" "597.1" "658.1" "619.6" "596.7" "486.8" "509.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6701833234650983688" "False" "High" "IsMasterProtein" "O43865" "S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2" "0.000" "False" "34.826" "17" "9" "13" "4" "530" "58.9" "6.89" "38.40" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00670, Pf05221" "10768" "ENSG00000168710" "AHCYL1" "B4E168; hsa:10768; O43865; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "12" "3" "1.028" "0.780" "1.221" "1.040" "0.770" "1.043" "1.085" "0.910" "0.815" "574.9" "590.8" "448.7" "702.2" "598.1" "442.5" "599.5" "624.0" "523.1" "468.8" "" "" "" "" "" "" "" "" "" "" "519.0" "455.7" "347.0" "472.8" "498.9" "377.7" "508.5" "451.6" "352.8" "468.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2413702222549115072" "False" "High" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "0.000" "False" "34.824" "20" "3" "15" "3" "172" "19.6" "4.93" "52.58" "3" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "0.992" "1.019" "1.006" "0.931" "1.042" "0.923" "0.944" "1.006" "0.828" "1083.7" "1075.4" "1104.7" "1090.3" "1009.2" "1129.6" "1000.6" "1023.1" "1090.0" "897.7" "" "" "" "" "" "" "" "" "" "" "978.3" "829.5" "854.4" "734.2" "841.8" "964.1" "848.8" "740.4" "735.2" "897.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2749057131699299074" "False" "High" "IsMasterProtein" "Q9BSY4" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 OS=Homo sapiens OX=9606 GN=CHCHD5 PE=1 SV=1" "0.000" "False" "34.778" "49" "4" "8" "4" "110" "12.4" "6.73" "23.47" "4" "other metabolic processes" "mitochondrion" "" "Pf06747, Pf16860" "84269" "ENSG00000125611" "CHCHD5" "hsa:84269; Q585T4; Q8N8C4; Q9BSY4" "Mitochondrial protein import" "2q13 copy number variation syndrome" "2" "0" "1.215" "0.926" "1.019" "1.238" "1.104" "1.163" "1.148" "1.100" "0.897" "90.7" "110.3" "84.0" "92.5" "112.3" "100.2" "105.5" "104.2" "99.8" "81.4" "" "" "" "" "" "" "" "" "" "" "81.9" "85.0" "65.0" "62.3" "93.7" "85.5" "89.5" "75.4" "67.3" "81.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719545438223687688" "False" "High" "IsMasterProtein" "Q9NWV8" "BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1" "0.000" "False" "34.766" "22" "5" "6" "5" "329" "36.5" "4.64" "22.49" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "" "29086" "ENSG00000105393" "BABAM1" "A8MQT0; B4DRY9; B4DVR1; hsa:29086; Q6FIA0; Q9NWV8; Q9P018" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "1.062" "1.111" "1.194" "1.205" "0.921" "1.041" "1.168" "1.125" "0.892" "110.1" "117.0" "122.3" "131.5" "132.7" "101.4" "114.6" "128.6" "123.9" "98.2" "" "" "" "" "" "" "" "" "" "" "99.4" "90.2" "94.6" "88.5" "110.7" "86.6" "97.2" "93.1" "83.5" "98.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257643935121491465" "False" "High" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "0.000" "False" "34.679" "18" "8" "9" "8" "406" "46.9" "8.37" "30.94" "8" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "" "2" "0" "1.009" "0.880" "0.980" "1.000" "0.802" "1.080" "1.026" "0.814" "0.785" "830.0" "837.3" "730.5" "813.5" "829.9" "665.9" "896.8" "851.7" "675.7" "651.2" "" "" "" "" "" "" "" "" "" "" "749.2" "645.9" "565.0" "547.8" "692.3" "568.4" "760.7" "616.4" "455.8" "651.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659608677254824690" "False" "High" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "0.000" "False" "34.602" "15" "5" "8" "5" "386" "43.2" "7.17" "26.66" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "Inactivation, recovery and regulation of the phototransduction cascade" "" "1" "0" "0.989" "0.885" "0.972" "0.965" "0.990" "0.922" "0.932" "1.018" "1.305" "344.2" "340.3" "304.8" "334.4" "332.2" "340.7" "317.3" "320.9" "350.3" "449.1" "" "" "" "" "" "" "" "" "" "" "310.7" "262.5" "235.7" "225.2" "277.1" "290.8" "269.1" "232.2" "236.2" "449.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3533689105478908948" "False" "High" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "0.000" "False" "34.601" "47" "4" "10" "4" "112" "12.5" "4.78" "36.24" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "22" "0" "1.010" "1.086" "0.815" "1.040" "0.962" "0.922" "0.969" "1.030" "0.789" "337.3" "340.7" "366.4" "274.8" "350.9" "324.6" "311.1" "326.8" "347.3" "266.2" "" "" "" "" "" "" "" "" "" "" "304.5" "262.8" "283.4" "185.1" "292.7" "277.0" "263.9" "236.5" "234.3" "266.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762043181650020657" "False" "High" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "0.000" "False" "34.572" "24" "5" "8" "5" "303" "33.8" "6.74" "30.23" "5" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Downstream signal transduction; Regulation of signaling by CBL; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1; MET receptor recycling" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "22" "0" "1.000" "1.136" "1.185" "1.091" "1.057" "1.128" "1.038" "1.132" "2.114" "203.8" "203.8" "231.5" "241.6" "222.5" "215.4" "230.0" "211.6" "230.7" "430.8" "" "" "" "" "" "" "" "" "" "" "184.0" "157.2" "179.1" "162.7" "185.6" "183.9" "195.1" "153.2" "155.6" "430.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802670806529502835" "False" "High" "IsMasterProtein" "Q6NYC8" "Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1" "0.000" "False" "34.572" "14" "7" "8" "7" "613" "67.9" "5.40" "29.24" "7" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf13914, Pf13916" "170954" "ENSG00000146112; ENSG00000206485; ENSG00000225060; ENSG00000229998; ENSG00000230341; ENSG00000234000" "PPP1R18" "A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; hsa:170954; Q68CK8; Q6NYC8; Q6ZTV1; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9" "" "TYROBP causal network in microglia" "1" "0" "0.985" "1.163" "0.946" "1.013" "1.187" "1.016" "0.986" "1.282" "0.946" "315.5" "310.9" "367.0" "298.4" "319.7" "374.6" "320.6" "311.2" "404.5" "298.3" "" "" "" "" "" "" "" "" "" "" "284.8" "239.8" "283.8" "201.0" "266.7" "319.7" "271.9" "225.2" "272.8" "298.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6604733771635373365" "False" "High" "IsMasterProtein" "P84085" "ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2" "0.000" "False" "34.569" "31" "5" "14" "2" "180" "20.5" "6.79" "37.77" "5" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "381" "ENSG00000004059" "ARF5" "hsa:381; P26437; P84085" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2q37 copy number variation syndrome" "3" "0" "0.974" "1.005" "0.923" "0.927" "0.926" "0.874" "1.014" "0.946" "0.659" "364.7" "355.4" "366.6" "336.6" "338.1" "337.8" "318.7" "369.7" "344.9" "240.2" "" "" "" "" "" "" "" "" "" "" "329.2" "274.1" "283.6" "226.7" "282.0" "288.3" "270.3" "267.6" "232.6" "240.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8476150003951297336" "False" "High" "IsMasterProtein" "Q96KG9" "N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1" "0.000" "False" "34.568" "10" "8" "11" "8" "808" "89.6" "6.30" "32.51" "8" "stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "57410" "ENSG00000142186" "SCYL1" "A6NJF1; hsa:57410; Q96G50; Q96KG8; Q96KG9; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53" "" "" "0" "0" "0.978" "0.953" "0.977" "1.015" "0.882" "1.014" "0.979" "0.924" "1.109" "367.9" "359.9" "350.5" "359.5" "373.5" "324.4" "372.9" "360.2" "340.0" "408.0" "" "" "" "" "" "" "" "" "" "" "332.1" "277.6" "271.1" "242.1" "311.5" "276.8" "316.3" "260.7" "229.3" "408.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4078763853778873139" "False" "High" "IsMasterProtein" "O95816" "BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1" "0.000" "False" "34.506" "26" "6" "7" "6" "211" "23.8" "6.70" "26.42" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "9532" "ENSG00000112208" "BAG2" "B4DXE2; hsa:9532; O95816; Q08AS9; Q6FID0" "Regulation of HSF1-mediated heat shock response" "Pleural mesothelioma" "2" "0" "0.894" "1.050" "0.984" "0.906" "1.062" "0.898" "0.809" "1.032" "2.165" "555.5" "496.5" "583.1" "546.6" "503.5" "590.0" "498.6" "449.7" "573.2" "1202.6" "" "" "" "" "" "" "" "" "" "" "501.4" "383.0" "451.0" "368.1" "420.0" "503.6" "422.9" "325.4" "386.6" "1202.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006297447401564784" "False" "High" "IsMasterProtein" "Q96B23" "Protein ARK2N OS=Homo sapiens OX=9606 GN=ARK2N PE=1 SV=3" "0.000" "False" "34.487" "12" "4" "10" "4" "404" "43.4" "4.88" "32.70" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15303" "147339" "ENSG00000152242" "ARK2N" "A8K123; A8KAB6; hsa:147339; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5; Q96B23" "" "" "0" "0" "0.912" "0.908" "0.967" "0.943" "0.919" "0.998" "1.022" "0.876" "0.807" "511.8" "466.8" "465.0" "494.8" "482.8" "470.3" "510.9" "523.1" "448.4" "413.0" "" "" "" "" "" "" "" "" "" "" "462.0" "360.0" "359.6" "333.2" "402.7" "401.4" "433.4" "378.6" "302.4" "413.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3957617844882623254" "False" "High" "IsMasterProtein" "Q7Z3B4" "Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2" "0.000" "False" "34.442" "14" "7" "9" "7" "507" "55.4" "7.02" "22.51" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13874, Pf18437" "53371" "ENSG00000138750" "NUP54" "B2RCK7; B4DT35; hsa:53371; Q7Z3B4; Q96EA7; Q9NVL5; Q9P0I1" "HCMV Early Events; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "0.982" "0.931" "0.996" "1.070" "0.905" "1.071" "1.044" "0.923" "0.958" "413.9" "406.4" "385.6" "412.4" "442.9" "374.5" "443.4" "432.0" "382.2" "396.5" "" "" "" "" "" "" "" "" "" "" "373.6" "313.5" "298.2" "277.7" "369.5" "319.6" "376.2" "312.6" "257.8" "396.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3635452200201599036" "False" "High" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "0.000" "False" "34.437" "25" "7" "10" "7" "312" "34.3" "8.43" "30.28" "7" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Ciliary landscape" "3" "0" "0.878" "0.807" "0.853" "0.939" "0.849" "0.891" "0.817" "0.895" "2.727" "304.7" "267.5" "245.8" "259.9" "285.9" "258.8" "271.4" "248.8" "272.8" "830.9" "" "" "" "" "" "" "" "" "" "" "275.0" "206.3" "190.1" "175.0" "238.5" "220.8" "230.3" "180.1" "184.0" "830.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454366493935613494" "False" "High" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "0.000" "False" "34.428" "24" "4" "8" "4" "249" "27.4" "8.06" "29.80" "4" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "1.272" "1.210" "1.246" "1.077" "1.325" "1.173" "1.258" "1.383" "0.750" "186.6" "237.3" "225.8" "232.5" "201.0" "247.2" "218.9" "234.7" "258.0" "140.0" "" "" "" "" "" "" "" "" "" "" "168.4" "183.0" "174.6" "156.6" "167.7" "211.0" "185.7" "169.9" "174.0" "140.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2016868097673482949" "False" "High" "IsMasterProtein" "Q9GZY6" "Linker for activation of T-cells family member 2 OS=Homo sapiens OX=9606 GN=LAT2 PE=1 SV=1" "0.000" "False" "34.406" "20" "4" "6" "4" "243" "26.5" "4.78" "20.44" "4" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15703" "7462" "ENSG00000086730" "LAT2" "A6NFK6; A8K209; A8K4F1; D3DXF9; hsa:7462; Q9BXX8; Q9GZY6; Q9NZY9" "Role of LAT2/NTAL/LAB on calcium mobilization" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome" "3" "0" "0.968" "0.833" "1.030" "1.064" "0.836" "1.011" "1.067" "0.950" "0.736" "290.3" "281.2" "241.9" "299.1" "309.1" "242.8" "293.5" "309.7" "275.9" "213.8" "" "" "" "" "" "" "" "" "" "" "262.1" "216.9" "187.1" "201.4" "257.8" "207.2" "249.0" "224.1" "186.1" "213.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1941852327752543049" "False" "High" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "0.000" "False" "34.356" "7" "9" "12" "9" "1102" "128.2" "5.55" "33.03" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Regulation of TP53 Degradation; Ub-specific processing proteases; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of PTEN localization" "Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates" "10" "0" "0.762" "0.737" "1.118" "0.753" "0.811" "0.704" "0.754" "0.778" "3.762" "21.7" "16.6" "16.0" "24.3" "16.4" "17.6" "15.3" "16.4" "16.9" "81.8" "" "" "" "" "" "" "" "" "" "" "19.6" "12.8" "12.4" "16.4" "13.7" "15.0" "13.0" "11.9" "11.4" "81.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952075756115425488" "False" "High" "IsMasterProtein" "Cont_P34955" "Alpha-1-antiproteinase OS=Bos taurus OX=9913 GN=SERPINA1 PE=1 SV=1" "0.000" "True" "34.306" "19" "9" "16" "9" "416" "46.1" "6.52" "49.47" "9" "" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "109575576; 280699" "ENSBIXG00000014418; ENSBIXG00005018236; ENSBTAG00000018843" "SERPINA1" "A0A4W2DYT6; A0A6P5DQE7; biu:109575576; bta:280699; P34955; Q3SZS3" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER; COPII-mediated vesicle transport" "Complement and coagulation cascades; NRF2 pathway" "8" "0" "1.148" "1.087" "1.183" "1.028" "1.462" "1.014" "1.082" "1.660" "0.857" "1281.8" "1471.8" "1393.1" "1516.3" "1317.3" "1874.5" "1299.7" "1387.2" "2127.5" "1098.1" "" "" "" "" "" "" "" "" "" "" "1157.1" "1135.3" "1077.5" "1021.0" "1098.9" "1599.9" "1102.5" "1003.9" "1435.0" "1098.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "306109377846906281" "False" "High" "IsMasterProtein" "P49247" "Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3" "0.000" "False" "34.181" "23" "7" "10" "7" "311" "33.2" "8.54" "35.76" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf06026" "22934" "ENSG00000153574" "RPIA" "hsa:22934; P49247; Q541P9; Q96BJ6" "Pentose phosphate pathway; RPIA deficiency: failed conversion of R5P to RU5P; RPIA deficiency: failed conversion of RU5P to R5P" "Pentose phosphate metabolism; Metabolic reprogramming in colon cancer; Pentose phosphate pathway in senescent cells" "6" "0" "1.005" "0.910" "0.996" "0.986" "0.969" "0.969" "0.974" "0.936" "0.690" "816.2" "820.6" "742.6" "812.8" "804.6" "791.2" "791.0" "795.4" "764.0" "563.5" "" "" "" "" "" "" "" "" "" "" "736.8" "633.0" "574.3" "547.3" "671.2" "675.3" "671.0" "575.6" "515.3" "563.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325736081283403068" "False" "High" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "0.000" "False" "34.175" "14" "7" "14" "7" "526" "53.4" "9.36" "45.68" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "MECP2 and associated Rett syndrome; mRNA processing; HDAC6 interactions in the central nervous system" "5" "0" "1.059" "1.201" "0.968" "1.017" "1.183" "0.908" "1.032" "1.123" "0.715" "694.8" "735.7" "834.5" "672.9" "706.6" "821.7" "630.6" "716.9" "780.6" "496.8" "" "" "" "" "" "" "" "" "" "" "627.2" "567.4" "645.4" "453.1" "589.4" "701.3" "534.9" "518.8" "526.5" "496.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7478524853152137733" "False" "High" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "0.000" "False" "34.152" "19" "4" "25" "4" "201" "23.3" "5.29" "71.69" "4" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "Rev-mediated nuclear export of HIV RNA" "22q11.2 copy number variation syndrome" "2" "0" "0.992" "0.897" "1.007" "0.962" "0.870" "0.965" "1.078" "0.856" "1.112" "1578.8" "1566.5" "1415.9" "1590.3" "1518.5" "1374.2" "1522.9" "1702.6" "1352.1" "1755.9" "" "" "" "" "" "" "" "" "" "" "1425.1" "1208.3" "1095.1" "1070.9" "1266.6" "1172.9" "1291.9" "1232.2" "912.0" "1755.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9217624131527771053" "False" "High" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "0.000" "False" "34.133" "16" "8" "11" "8" "501" "54.1" "8.66" "37.09" "8" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "Amino acid metabolism" "5" "0" "0.962" "0.932" "0.865" "0.956" "0.911" "1.043" "0.955" "0.972" "0.722" "733.2" "705.1" "683.7" "634.3" "700.7" "668.1" "765.0" "700.1" "712.7" "529.5" "" "" "" "" "" "" "" "" "" "" "661.8" "543.9" "528.8" "427.1" "584.5" "570.2" "648.9" "506.7" "480.7" "529.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574193745658390357" "False" "High" "IsMasterProtein" "P46926" "Glucosamine-6-phosphate isomerase 1 OS=Homo sapiens OX=9606 GN=GNPDA1 PE=1 SV=1" "0.000" "False" "34.109" "19" "5" "10" "4" "289" "32.6" "6.92" "26.92" "5" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01182" "10007" "ENSG00000113552" "GNPDA1" "B7Z3X4; D3DQE7; hsa:10007; P46926" "Glycolysis" "" "1" "1" "0.991" "1.037" "1.044" "0.968" "1.099" "0.998" "1.073" "1.048" "0.766" "508.1" "503.4" "527.2" "530.5" "492.0" "558.3" "506.9" "545.0" "532.6" "389.4" "" "" "" "" "" "" "" "" "" "" "458.7" "388.3" "407.7" "357.3" "410.4" "476.5" "430.0" "394.4" "359.2" "389.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3553931004733427798" "False" "High" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "0.000" "False" "34.093" "24" "3" "21" "3" "86" "9.7" "4.67" "66.08" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.016" "1.061" "1.079" "1.077" "1.032" "0.941" "0.936" "1.087" "0.692" "835.1" "848.3" "886.2" "901.5" "899.7" "862.0" "785.5" "781.6" "907.4" "578.3" "" "" "" "" "" "" "" "" "" "" "753.8" "654.3" "685.4" "607.0" "750.5" "735.7" "666.4" "565.6" "612.0" "578.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7944368975479606522" "False" "High" "IsMasterProtein" "O94979" "Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3" "0.000" "False" "34.059" "7" "9" "10" "9" "1220" "132.9" "6.89" "33.08" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf12931" "22872" "ENSG00000138674" "SEC31A" "B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; hsa:22872; O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "6" "0" "0.978" "1.017" "1.124" "1.037" "1.089" "1.082" "0.820" "1.099" "2.811" "499.3" "488.4" "507.6" "561.2" "517.7" "543.7" "540.3" "409.4" "548.9" "1403.7" "" "" "" "" "" "" "" "" "" "" "450.7" "376.7" "392.6" "377.9" "431.8" "464.0" "458.3" "296.3" "370.2" "1403.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6750207652327358618" "False" "High" "IsMasterProtein" "O43719" "17S U2 SnRNP complex component HTATSF1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1" "0.000" "False" "34.047" "12" "11" "11" "11" "755" "85.8" "4.40" "31.58" "11" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "27336" "ENSG00000102241" "HTATSF1" "D3DWG9; hsa:27336; O43719; Q59G06; Q99730" "mRNA Splicing - Major Pathway" "" "1" "0" "1.027" "1.350" "1.102" "1.026" "1.294" "1.018" "0.769" "1.381" "6.026" "492.9" "506.3" "665.3" "542.9" "505.8" "637.7" "501.8" "379.1" "680.9" "2970.4" "" "" "" "" "" "" "" "" "" "" "444.9" "390.5" "514.6" "365.6" "422.0" "544.3" "425.7" "274.3" "459.2" "2970.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678846149867540289" "False" "High" "IsMasterProtein" "Q9H4A4" "Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2" "0.000" "False" "33.976" "14" "8" "10" "8" "650" "72.5" "5.74" "27.95" "8" "protein metabolism" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01433, Pf09127, Pf17900" "6051" "ENSG00000176393" "RNPEP" "hsa:6051; Q9BVM9; Q9H1D4; Q9H4A4; Q9NPT7" "" "" "0" "0" "0.968" "0.966" "0.950" "0.998" "1.048" "0.976" "0.941" "0.946" "1.724" "247.9" "240.0" "239.5" "235.6" "247.3" "259.7" "242.0" "233.2" "234.5" "427.4" "" "" "" "" "" "" "" "" "" "" "223.8" "185.2" "185.3" "158.6" "206.3" "221.7" "205.3" "168.7" "158.1" "427.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5446146544739154360" "False" "High" "IsMasterProtein" "Q15654" "Thyroid receptor-interacting protein 6 OS=Homo sapiens OX=9606 GN=TRIP6 PE=1 SV=3" "0.000" "False" "33.946" "19" "7" "10" "7" "476" "50.3" "7.37" "31.92" "7" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00412" "7205" "ENSG00000087077" "TRIP6" "A4D2E7; F2ZC07; F2ZC08; hsa:7205; O15170; O15275; Q15654; Q9BTB2; Q9BUE5; Q9BXP3; Q9UNT4" "" "" "0" "0" "1.051" "0.965" "1.089" "1.063" "1.010" "1.069" "1.033" "0.998" "0.968" "277.4" "291.6" "267.5" "302.1" "295.0" "280.1" "296.4" "286.7" "276.8" "268.5" "" "" "" "" "" "" "" "" "" "" "250.4" "224.9" "206.9" "203.4" "246.1" "239.1" "251.4" "207.4" "186.7" "268.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2037005348220660879" "False" "High" "IsMasterProtein" "O00151" "PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4" "0.000" "False" "33.910" "17" "5" "10" "5" "329" "36.0" "7.02" "37.19" "5" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "9124" "ENSG00000107438" "PDLIM1" "B2RBS6; hsa:9124; O00151; Q5VZH5; Q9BPZ9" "" "" "0" "0" "0.973" "0.945" "1.002" "1.043" "0.940" "1.001" "1.070" "0.974" "0.702" "590.8" "574.9" "558.2" "591.9" "616.4" "555.2" "591.5" "632.1" "575.7" "414.5" "" "" "" "" "" "" "" "" "" "" "533.3" "443.4" "431.7" "398.6" "514.1" "473.9" "501.7" "457.5" "388.3" "414.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8845776874603627941" "False" "High" "IsMasterProtein" "Q92930" "Ras-related protein Rab-8B OS=Homo sapiens OX=9606 GN=RAB8B PE=1 SV=2" "0.000" "False" "33.898" "31" "7" "11" "2" "207" "23.6" "9.07" "35.46" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "51762" "ENSG00000166128" "RAB8B" "hsa:51762; Q5JPC4; Q92930; Q9P293" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "Ectoderm differentiation; Ectoderm differentiation" "5" "0" "0.933" "1.159" "0.888" "0.958" "1.015" "1.025" "1.092" "1.077" "0.694" "131.3" "122.5" "152.2" "116.6" "125.7" "133.2" "134.6" "143.4" "141.5" "91.2" "" "" "" "" "" "" "" "" "" "" "118.5" "94.5" "117.7" "78.5" "104.9" "113.7" "114.1" "103.8" "95.4" "91.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222501069186758979" "False" "High" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "0.000" "False" "33.866" "16" "5" "7" "5" "341" "37.5" "7.43" "24.38" "5" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "1.052" "1.005" "0.978" "0.878" "0.860" "1.138" "0.966" "0.948" "0.695" "117.2" "123.3" "117.8" "114.7" "102.9" "100.8" "133.3" "113.2" "111.1" "81.4" "" "" "" "" "" "" "" "" "" "" "105.8" "95.1" "91.1" "77.2" "85.9" "86.0" "113.1" "81.9" "74.9" "81.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936479494832144237" "False" "High" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "0.000" "False" "33.853" "12" "9" "12" "9" "783" "85.9" "7.77" "28.66" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "Mitochondrial RNA degradation" "Pyrimidine metabolism; miRNA degrading enzymes" "3" "0" "1.064" "0.885" "0.970" "1.023" "0.943" "1.052" "0.936" "0.948" "2.084" "293.1" "311.8" "259.5" "284.4" "299.9" "276.4" "308.4" "274.2" "277.9" "610.8" "" "" "" "" "" "" "" "" "" "" "264.6" "240.5" "200.7" "191.5" "250.2" "235.9" "261.6" "198.5" "187.5" "610.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3945672141617060885" "False" "High" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "0.000" "False" "33.829" "6" "7" "7" "7" "1410" "152.4" "8.60" "20.17" "7" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Signaling by ALK fusions and activated point mutants" "Ectoderm differentiation" "2" "0" "1.406" "1.085" "2.205" "1.419" "1.177" "1.463" "1.094" "1.555" "1.010" "95.7" "134.6" "103.8" "211.0" "135.8" "112.6" "140.0" "104.7" "148.8" "96.6" "" "" "" "" "" "" "" "" "" "" "86.4" "103.8" "80.3" "142.1" "113.2" "96.1" "118.7" "75.8" "100.4" "96.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7115142250704838097" "False" "High" "IsMasterProtein" "P08670" "Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4" "0.000" "False" "33.746" "21" "10" "11" "9" "466" "53.6" "5.12" "30.61" "10" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf04732" "7431" "ENSG00000026025" "VIM" "B0YJC2; D3DRU4; hsa:7431; P08670; Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3" "Aggrephagy; Interleukin-4 and Interleukin-13 signaling; Chaperone Mediated Autophagy; Late endosomal microautophagy; Striated Muscle Contraction; RHOBTB1 GTPase cycle; Caspase-mediated cleavage of cytoskeletal proteins" "Allograft rejection; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Puberty (Stage 2 of 4); Apoptosis-related network due to altered Notch3 in ovarian cancer; Striated muscle contraction pathway; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Ciliary landscape; Burn wound healing; CCL18 signaling pathway; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "21" "0" "1.043" "1.230" "1.138" "1.057" "1.235" "1.058" "1.135" "1.255" "0.702" "377.2" "393.5" "464.1" "429.3" "398.7" "465.8" "399.2" "428.1" "473.5" "265.0" "" "" "" "" "" "" "" "" "" "" "340.5" "303.5" "359.0" "289.1" "332.6" "397.6" "338.6" "309.8" "319.3" "265.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962903921157164287" "False" "High" "IsMasterProtein" "Q8IYD1" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B OS=Homo sapiens OX=9606 GN=GSPT2 PE=1 SV=2" "0.000" "False" "33.736" "13" "9" "10" "3" "628" "68.8" "5.43" "30.86" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf07145" "23708" "ENSG00000189369" "GSPT2" "hsa:23708; Q8IYD1; Q9H909; Q9NVY0; Q9NY44" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Translation factors" "5" "0" "1.035" "0.922" "1.249" "0.884" "0.695" "1.071" "1.090" "0.924" "1.042" "83.0" "85.8" "76.5" "103.6" "73.4" "57.7" "88.8" "90.4" "76.7" "86.4" "" "" "" "" "" "" "" "" "" "" "74.9" "66.2" "59.2" "69.8" "61.2" "49.2" "75.4" "65.4" "51.7" "86.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452221919959736930" "False" "High" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "0.000" "False" "33.719" "8" "7" "9" "7" "1294" "141.0" "8.40" "24.27" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348, Pf21040" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "7q11.23 copy number variation syndrome" "8" "0" "1.160" "1.033" "1.239" "1.085" "1.116" "1.201" "0.955" "1.162" "1.302" "193.0" "223.9" "199.4" "239.2" "209.4" "215.3" "231.7" "184.3" "224.4" "251.4" "" "" "" "" "" "" "" "" "" "" "174.2" "172.7" "154.2" "161.1" "174.7" "183.8" "196.6" "133.4" "151.3" "251.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516016884332694472" "False" "High" "IsMasterProtein" "O60361" "Putative nucleoside diphosphate kinase OS=Homo sapiens OX=9606 GN=NME2P1 PE=5 SV=1" "0.000" "False" "33.691" "40" "6" "38" "1" "137" "15.5" "8.57" "100.94" "6" "other metabolic processes;other biological processes" "" "kinase activity;other molecular function" "Pf00334" "" "" "NME2P1" "O60361" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "380147253527428052" "False" "High" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "0.000" "False" "33.672" "9" "4" "8" "2" "601" "63.8" "5.22" "28.75" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "2" "0.984" "0.949" "1.148" "0.993" "0.995" "0.960" "1.037" "0.946" "0.814" "306.2" "301.3" "290.6" "351.4" "304.1" "304.7" "293.9" "317.5" "289.5" "249.3" "" "" "" "" "" "" "" "" "" "" "276.4" "232.4" "224.8" "236.7" "253.7" "260.1" "249.3" "229.8" "195.3" "249.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211480978683405727" "False" "High" "IsMasterProtein" "O95232" "Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2" "0.000" "False" "33.627" "18" "8" "10" "8" "432" "51.4" "9.79" "28.80" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf03194" "51747" "ENSG00000108848" "LUC7L3" "B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7" "mRNA Splicing - Major Pathway" "" "1" "0" "1.012" "1.075" "1.077" "1.099" "1.044" "1.109" "1.111" "0.973" "0.913" "192.4" "194.8" "206.9" "207.2" "211.4" "200.9" "213.4" "213.7" "187.2" "175.7" "" "" "" "" "" "" "" "" "" "" "173.7" "150.2" "160.0" "139.6" "176.3" "171.4" "181.0" "154.7" "126.2" "175.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1849398190907063362" "False" "High" "IsMasterProtein" "P35813" "Protein phosphatase 1A OS=Homo sapiens OX=9606 GN=PPM1A PE=1 SV=1" "0.000" "False" "33.589" "18" "6" "6" "4" "382" "42.4" "5.36" "20.68" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5494" "ENSG00000100614" "PPM1A" "B5BU11; hsa:5494; J3KNM0; O75551; P35813" "Energy dependent regulation of mTOR by LKB1-AMPK; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "TGF-beta signaling pathway; MAPK signaling pathway" "4" "0" "1.075" "1.130" "1.037" "1.020" "1.150" "1.036" "1.046" "1.052" "0.917" "269.9" "290.2" "305.1" "280.0" "275.3" "310.5" "279.7" "282.4" "283.9" "247.5" "" "" "" "" "" "" "" "" "" "" "243.7" "223.8" "236.0" "188.5" "229.6" "265.0" "237.3" "204.4" "191.5" "247.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2410269861090895387" "False" "High" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "0.000" "False" "33.578" "11" "6" "8" "6" "677" "73.3" "4.84" "29.41" "6" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "1.037" "1.062" "1.086" "0.976" "1.009" "1.038" "0.756" "1.050" "5.835" "342.4" "355.1" "363.8" "371.9" "334.1" "345.5" "355.5" "258.7" "359.6" "1998.0" "" "" "" "" "" "" "" "" "" "" "309.1" "273.9" "281.3" "250.4" "278.7" "294.9" "301.6" "187.2" "242.5" "1998.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201863361074030149" "False" "High" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0.000" "False" "33.402" "3" "8" "8" "8" "2799" "309.2" "5.85" "24.18" "8" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "" "Mesodermal commitment pathway" "1" "0" "0.994" "0.927" "1.049" "1.093" "0.994" "0.999" "0.852" "1.028" "3.476" "390.1" "387.9" "361.7" "409.4" "426.2" "387.7" "389.6" "332.5" "401.0" "1356.1" "" "" "" "" "" "" "" "" "" "" "352.1" "299.2" "279.8" "275.7" "355.6" "330.9" "330.5" "240.6" "270.5" "1356.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4281551287497306931" "False" "High" "IsMasterProtein" "Q9Y2B9" "cAMP-dependent protein kinase inhibitor gamma OS=Homo sapiens OX=9606 GN=PKIG PE=1 SV=1" "0.000" "False" "33.368" "72" "3" "10" "3" "76" "7.9" "4.25" "32.28" "3" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf02827" "11142" "ENSG00000168734" "PKIG" "hsa:11142; Q9Y2B9" "" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "2" "0" "1.067" "0.879" "1.087" "0.998" "0.918" "1.042" "1.092" "0.981" "0.758" "368.0" "392.7" "323.3" "400.1" "367.4" "337.9" "383.4" "402.1" "361.0" "279.0" "" "" "" "" "" "" "" "" "" "" "332.2" "302.9" "250.1" "269.5" "306.5" "288.4" "325.2" "291.0" "243.5" "279.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5860856138791644160" "False" "High" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "0.000" "False" "33.344" "11" "7" "11" "4" "579" "62.3" "8.79" "41.16" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "3" "0.966" "1.259" "1.022" "1.043" "1.231" "1.052" "0.963" "1.233" "1.226" "1030.6" "995.4" "1297.9" "1053.5" "1074.9" "1268.8" "1084.4" "992.6" "1270.7" "1263.6" "" "" "" "" "" "" "" "" "" "" "930.3" "767.8" "1003.8" "709.4" "896.6" "1082.9" "919.9" "718.3" "857.1" "1263.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1694253408134936187" "False" "High" "IsMasterProtein" "P50452" "Serpin B8 OS=Homo sapiens OX=9606 GN=SERPINB8 PE=1 SV=2" "0.000" "False" "33.339" "18" "6" "10" "6" "374" "42.7" "5.57" "30.42" "6" "cell adhesion;other biological processes" "non-structural extracellular;cytosol;other cell component" "enzyme regulator activity" "Pf00079" "5271" "ENSG00000166401" "SERPINB8" "B4DTW2; P50452; Q7Z2V6; Q8N178" "Dissolution of Fibrin Clot" "" "1" "0" "0.997" "1.016" "0.978" "0.963" "1.061" "0.995" "0.951" "1.035" "0.783" "486.2" "484.9" "493.8" "475.7" "468.0" "516.0" "483.6" "462.2" "503.1" "380.5" "" "" "" "" "" "" "" "" "" "" "438.9" "374.0" "382.0" "320.4" "390.4" "440.4" "410.2" "334.5" "339.4" "380.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939496649029224586" "False" "High" "IsMasterProtein" "P51812" "Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1" "0.000" "False" "33.298" "15" "11" "14" "5" "740" "83.7" "6.89" "35.48" "11" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6197" "ENSG00000177189" "RPS6KA3" "B2R9V4; hsa:6197; P51812; Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7" "Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Thermogenesis; EGF/EGFR signaling pathway; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "18" "1" "1.012" "0.833" "0.787" "1.015" "0.866" "0.935" "0.864" "0.840" "1.812" "273.7" "277.0" "228.0" "215.4" "277.8" "237.0" "255.9" "236.4" "230.0" "496.0" "" "" "" "" "" "" "" "" "" "" "247.1" "213.7" "176.3" "145.1" "231.7" "202.3" "217.1" "171.1" "155.1" "496.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646887584104105884" "False" "High" "IsMasterProtein" "Q9BW61" "DET1- and DDB1-associated protein 1 OS=Homo sapiens OX=9606 GN=DDA1 PE=1 SV=1" "0.000" "False" "33.274" "28" "3" "6" "3" "102" "11.8" "8.68" "21.18" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10172" "79016" "ENSG00000130311" "DDA1" "hsa:79016; Q9BW61" "Neddylation" "" "1" "0" "0.892" "0.924" "1.000" "1.034" "0.982" "0.975" "0.933" "1.008" "1.071" "192.3" "171.6" "177.7" "192.4" "198.8" "188.9" "187.5" "179.4" "193.8" "205.9" "" "" "" "" "" "" "" "" "" "" "173.6" "132.4" "137.5" "129.5" "165.8" "161.2" "159.1" "129.9" "130.7" "205.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910881260683280979" "False" "High" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "0.000" "False" "33.263" "19" "6" "10" "6" "299" "33.6" "4.81" "34.01" "6" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "1.041" "0.917" "1.040" "1.087" "0.825" "1.140" "1.105" "0.932" "0.742" "793.0" "825.4" "727.1" "824.5" "862.1" "654.3" "904.0" "876.1" "739.3" "588.8" "" "" "" "" "" "" "" "" "" "" "715.8" "636.6" "562.4" "555.2" "719.1" "558.5" "766.9" "634.0" "498.6" "588.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-34001002036977343" "False" "High" "IsMasterProtein" "O76003" "Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2" "0.000" "False" "33.248" "11" "3" "5" "3" "335" "37.4" "5.39" "19.98" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00085, Pf00462" "10539" "ENSG00000108010" "GLRX3" "B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1" "Iron uptake and transport" "" "1" "0" "0.998" "1.074" "1.049" "0.950" "1.048" "1.042" "0.971" "1.161" "2.056" "437.9" "437.0" "470.2" "459.5" "415.8" "458.9" "456.2" "425.1" "508.6" "900.3" "" "" "" "" "" "" "" "" "" "" "395.3" "337.1" "363.6" "309.5" "346.8" "391.7" "387.0" "307.6" "343.0" "900.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3973865475325375053" "False" "High" "IsMasterProtein" "P15374" "Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1" "0.000" "False" "33.200" "25" "5" "12" "5" "230" "26.2" "4.92" "38.03" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01088" "7347" "ENSG00000118939" "UCHL3" "B2R970; hsa:7347; P15374; Q5TBK8; Q6IBE9" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation" "Proteasome degradation" "4" "0" "1.051" "1.011" "0.943" "0.919" "1.066" "0.897" "1.010" "0.952" "0.923" "458.9" "482.4" "463.9" "432.9" "421.8" "489.1" "411.8" "463.5" "436.9" "423.5" "" "" "" "" "" "" "" "" "" "" "414.3" "372.1" "358.8" "291.5" "351.8" "417.5" "349.3" "335.4" "294.7" "423.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877506006391296740" "False" "High" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "0.000" "False" "33.191" "21" "5" "12" "5" "239" "25.3" "4.92" "39.03" "5" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.985" "1.174" "0.998" "1.032" "1.221" "1.002" "1.067" "1.199" "0.850" "816.6" "804.5" "958.6" "814.7" "843.2" "997.0" "818.3" "871.5" "979.3" "694.4" "" "" "" "" "" "" "" "" "" "" "737.1" "620.6" "741.5" "548.6" "703.3" "850.9" "694.2" "630.7" "660.6" "694.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6317068778034787864" "False" "High" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "0.000" "False" "33.086" "12" "6" "8" "6" "642" "72.9" "5.87" "29.68" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "0.962" "1.036" "1.027" "1.013" "1.029" "0.993" "0.917" "1.055" "1.645" "291.0" "280.1" "301.6" "299.0" "294.8" "299.4" "289.0" "266.9" "307.0" "478.9" "" "" "" "" "" "" "" "" "" "" "262.7" "216.1" "233.3" "201.4" "245.9" "255.6" "245.1" "193.2" "207.1" "478.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8782574511401724651" "False" "High" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "0.000" "False" "32.988" "16" "10" "14" "10" "593" "68.0" "7.30" "40.52" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PD-1 signaling; PIP3 activates AKT signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Signal regulatory protein family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; PI3K Cascade; GPVI-mediated activation cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; Platelet sensitization by LDL; PECAM1 interactions; CTLA4 inhibitory signaling; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "91" "0" "1.027" "1.010" "1.034" "0.989" "0.918" "1.041" "1.091" "0.979" "0.827" "936.9" "962.4" "945.8" "968.9" "926.6" "859.7" "975.7" "1022.4" "917.6" "774.7" "" "" "" "" "" "" "" "" "" "" "845.7" "742.3" "731.6" "652.4" "772.9" "733.8" "827.7" "739.9" "618.9" "774.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3372054881013806202" "False" "High" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "0.000" "False" "32.981" "29" "5" "10" "5" "263" "28.3" "8.38" "32.15" "5" "transport" "other membranes" "" "Pf07933" "55707" "ENSG00000157191; ENSG00000291380" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "0.999" "0.998" "1.324" "1.087" "0.933" "1.063" "0.985" "1.099" "0.983" "300.4" "300.0" "299.7" "397.8" "326.6" "280.2" "319.3" "296.0" "330.0" "295.4" "" "" "" "" "" "" "" "" "" "" "271.1" "231.4" "231.8" "267.9" "272.5" "239.1" "270.8" "214.2" "222.6" "295.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9034564449228548140" "False" "High" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "0.000" "False" "32.972" "26" "5" "10" "5" "188" "21.0" "5.14" "29.94" "5" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "Glutathione synthesis and recycling" "" "1" "0" "0.931" "1.004" "0.947" "0.876" "1.173" "0.941" "0.878" "1.072" "0.765" "456.1" "424.7" "457.7" "432.0" "399.7" "535.1" "429.1" "400.4" "489.0" "349.0" "" "" "" "" "" "" "" "" "" "" "411.7" "327.6" "354.0" "290.9" "333.4" "456.7" "364.0" "289.8" "329.8" "349.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "467994795181612484" "False" "High" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "0.000" "False" "32.966" "3" "7" "7" "5" "2442" "265.2" "8.53" "28.93" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; O00147; Q16376; Q4LE28; Q92793" "Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; NPAS4 regulates expression of target genes; Heme signaling; Formation of the beta-catenin:TCF transactivating complex; SUMOylation of transcription cofactors; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NFE2L2 regulating anti-oxidant/detoxification enzymes; HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; Rubinstein-Taybi syndrome 1; 15q11q13 copy number variation; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "74" "0" "0.951" "0.893" "0.911" "0.992" "0.883" "1.028" "0.977" "0.926" "0.961" "351.6" "334.3" "313.9" "320.1" "348.9" "310.5" "361.3" "343.5" "325.5" "337.7" "" "" "" "" "" "" "" "" "" "" "317.3" "257.9" "242.8" "215.6" "291.0" "265.0" "306.5" "248.6" "219.5" "337.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5418508312129097166" "False" "High" "IsMasterProtein" "P35626" "G protein-coupled receptor kinase 3 OS=Homo sapiens OX=9606 GN=GRK3 PE=1 SV=2" "0.000" "False" "32.952" "8" "5" "6" "1" "688" "79.7" "7.62" "21.16" "5" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "157" "ENSG00000100077" "GRK3" "hsa:157; P35626; Q9UGW9" "G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis" "Corticotropin-releasing hormone signaling pathway; Hedgehog signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209519133895389976" "False" "High" "IsMasterProtein" "Q9P107" "GEM-interacting protein OS=Homo sapiens OX=9606 GN=GMIP PE=1 SV=2" "0.000" "False" "32.905" "10" "8" "8" "8" "970" "106.6" "5.72" "26.13" "8" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00620" "51291" "ENSG00000089639" "GMIP" "A0AVN9; B7ZLZ0; hsa:51291; Q9P107" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle" "" "3" "0" "1.012" "1.256" "1.105" "1.017" "1.192" "0.956" "1.043" "1.200" "2.367" "276.0" "279.4" "346.7" "305.0" "280.6" "329.0" "263.9" "287.7" "331.3" "653.3" "" "" "" "" "" "" "" "" "" "" "249.1" "215.5" "268.1" "205.4" "234.1" "280.8" "223.9" "208.2" "223.4" "653.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2007854671863603578" "False" "High" "IsMasterProtein" "P46734" "Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2" "0.000" "False" "32.898" "16" "6" "9" "6" "347" "39.3" "7.43" "30.30" "6" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5606" "ENSG00000034152" "MAP2K3" "B3KSK7; hsa:5606; P46734; Q99441; Q9UE71; Q9UE72" "Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Endoderm differentiation; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "34" "0" "1.011" "0.907" "1.010" "1.147" "1.003" "1.055" "1.011" "0.969" "1.564" "508.2" "514.0" "461.1" "513.3" "582.7" "509.9" "536.0" "514.0" "492.6" "794.6" "" "" "" "" "" "" "" "" "" "" "458.7" "396.4" "356.6" "345.7" "486.0" "435.2" "454.7" "372.0" "332.3" "794.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5422158606125759469" "False" "High" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "0.000" "False" "32.889" "17" "6" "13" "6" "306" "32.7" "5.06" "41.83" "6" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "mRNA processing" "7" "0" "1.058" "1.598" "1.001" "1.083" "1.517" "1.000" "0.917" "1.578" "1.554" "913.8" "966.6" "1459.9" "915.1" "989.6" "1385.9" "914.1" "837.7" "1442.3" "1420.3" "" "" "" "" "" "" "" "" "" "" "824.8" "745.5" "1129.1" "616.2" "825.5" "1182.9" "775.4" "606.2" "972.8" "1420.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993927886623036395" "False" "High" "IsMasterProtein" "P31947" "14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1" "0.000" "False" "32.859" "17" "5" "46" "1" "248" "27.8" "4.74" "119.86" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "2810" "ENSG00000175793" "SFN" "hsa:2810; P31947; Q6FH30; Q6FH51; Q96DH0" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest" "miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; p53 transcriptional gene network; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; DNA damage response" "16" "0" "0.928" "0.997" "0.834" "0.877" "0.902" "0.959" "0.915" "0.918" "0.642" "240.8" "223.4" "240.0" "200.9" "211.1" "217.1" "231.0" "220.5" "221.0" "154.7" "" "" "" "" "" "" "" "" "" "" "217.4" "172.4" "185.6" "135.3" "176.1" "185.3" "196.0" "159.5" "149.1" "154.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926098929249154387" "False" "High" "IsMasterProtein" "Q9NR28" "Diablo IAP-binding mitochondrial protein OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "0.000" "False" "32.856" "32" "7" "12" "7" "239" "27.1" "5.90" "44.32" "7" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "Regulation of the apoptosome activity; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Release of apoptotic factors from the mitochondria" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "10" "0" "0.954" "0.788" "0.955" "0.984" "0.875" "0.975" "1.001" "0.847" "0.658" "560.2" "534.5" "441.3" "534.8" "551.4" "490.2" "546.0" "560.8" "474.7" "368.7" "" "" "" "" "" "" "" "" "" "" "505.7" "412.3" "341.3" "360.1" "459.9" "418.4" "463.1" "405.8" "320.2" "368.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3146791204946970239" "False" "High" "IsMasterProtein" "Q9Y6W5" "Actin-binding protein WASF2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "0.000" "False" "32.825" "16" "8" "10" "8" "498" "54.3" "5.53" "31.34" "8" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "Regulation of actin cytoskeleton" "8" "0" "1.022" "0.929" "1.060" "0.991" "0.904" "1.033" "1.060" "0.888" "1.107" "589.8" "602.6" "548.0" "625.0" "584.8" "533.0" "609.2" "625.2" "523.5" "652.7" "" "" "" "" "" "" "" "" "" "" "532.4" "464.8" "423.8" "420.9" "487.8" "454.9" "516.7" "452.5" "353.1" "652.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6844923263172623256" "False" "High" "IsMasterProtein" "Q9BXP5" "Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1" "0.000" "False" "32.816" "11" "10" "10" "10" "876" "100.6" "5.96" "30.55" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04959, Pf12066" "51593" "ENSG00000087087" "SRRT" "A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4" "mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes" "" "2" "0" "1.000" "1.360" "1.059" "0.999" "1.304" "0.998" "0.507" "1.367" "7.603" "295.3" "295.3" "401.6" "312.6" "294.9" "385.1" "294.7" "149.7" "403.8" "2245.5" "" "" "" "" "" "" "" "" "" "" "266.6" "227.8" "310.6" "210.5" "246.0" "328.7" "250.0" "108.3" "272.4" "2245.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3039044237151127382" "False" "High" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "0.000" "False" "32.658" "17" "5" "8" "4" "376" "42.6" "6.64" "30.98" "5" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "HDAC6 interactions in the central nervous system" "12" "1" "0.969" "1.051" "0.982" "0.986" "1.020" "1.107" "1.025" "1.090" "0.917" "608.7" "590.1" "639.6" "597.4" "600.1" "620.8" "673.9" "623.8" "663.2" "558.3" "" "" "" "" "" "" "" "" "" "" "549.4" "455.1" "494.7" "402.3" "500.6" "529.9" "571.7" "451.4" "447.4" "558.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4143955501491186019" "False" "High" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "0.000" "False" "32.638" "15" "7" "9" "7" "474" "51.3" "9.41" "23.16" "7" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "12" "0" "1.040" "0.987" "0.960" "1.045" "0.870" "1.030" "0.959" "0.818" "1.283" "406.0" "422.2" "400.9" "389.6" "424.4" "353.2" "418.3" "389.4" "332.2" "521.0" "" "" "" "" "" "" "" "" "" "" "366.5" "325.7" "310.1" "262.4" "354.0" "301.5" "354.9" "281.8" "224.1" "521.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653311583040189549" "False" "High" "IsMasterProtein" "Q9H2P9" "Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2" "0.000" "False" "32.598" "16" "4" "7" "4" "285" "31.6" "5.31" "28.10" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00590" "51611" "ENSG00000117543" "DPH5" "A8JZY6; D3DT62; hsa:51611; Q9H2P9; Q9P017; Q9P0I4; Q9Y319" "Synthesis of diphthamide-EEF2" "" "1" "0" "0.960" "0.957" "0.913" "0.997" "1.012" "0.854" "0.891" "1.016" "0.797" "443.1" "425.3" "424.2" "404.4" "441.9" "448.2" "378.4" "394.7" "450.1" "353.2" "" "" "" "" "" "" "" "" "" "" "400.0" "328.1" "328.1" "272.3" "368.6" "382.5" "321.0" "285.6" "303.6" "353.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3343567279109484109" "False" "High" "IsMasterProtein" "P61326" "Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1" "0.000" "False" "32.587" "32" "5" "16" "5" "146" "17.2" "6.11" "50.78" "5" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus" "" "Pf02792" "4116" "ENSG00000162385" "MAGOH" "B1ARP8; B2R5A2; hsa:4116; O35169; P50606; P61326; Q5SW69" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "TAR syndrome" "7" "0" "0.975" "1.072" "1.071" "1.017" "1.083" "0.968" "1.013" "1.175" "1.121" "782.3" "762.8" "838.4" "837.7" "795.8" "847.1" "757.1" "792.2" "919.6" "877.0" "" "" "" "" "" "" "" "" "" "" "706.2" "588.4" "648.5" "564.1" "663.9" "723.0" "642.2" "573.3" "620.2" "877.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858767456070720034" "False" "High" "IsMasterProtein" "P55735" "Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3" "0.000" "False" "32.584" "28" "7" "10" "7" "322" "35.5" "5.48" "34.89" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "6396" "ENSG00000157020" "SEC13" "A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Regulation of HSF1-mediated heat shock response; Separation of Sister Chromatids; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "Sterol regulatory element-binding proteins (SREBP) signaling" "40" "0" "1.023" "0.997" "1.019" "0.986" "0.986" "1.042" "0.938" "0.954" "1.686" "654.7" "669.6" "652.9" "667.1" "645.6" "645.6" "682.5" "614.1" "624.6" "1103.7" "" "" "" "" "" "" "" "" "" "" "591.0" "516.5" "504.9" "449.2" "538.5" "551.1" "579.0" "444.4" "421.3" "1103.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454971752249747449" "False" "High" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "0.000" "False" "32.538" "20" "3" "10" "3" "190" "20.7" "9.54" "36.40" "3" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "1.078" "0.831" "0.990" "1.068" "0.898" "1.009" "1.000" "0.877" "0.767" "383.1" "412.8" "318.5" "379.3" "408.9" "344.0" "386.6" "383.0" "335.9" "293.6" "" "" "" "" "" "" "" "" "" "" "345.8" "318.4" "246.3" "255.4" "341.1" "293.6" "328.0" "277.2" "226.6" "293.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5706954355209209913" "False" "High" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "0.000" "False" "32.487" "10" "3" "12" "3" "277" "29.9" "7.68" "37.65" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "ER-Phagosome pathway; Neutrophil degranulation; Ub-specific processing proteases; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "1.013" "1.118" "0.964" "1.052" "1.119" "1.065" "1.012" "1.125" "0.729" "991.1" "1003.7" "1107.8" "954.9" "1042.2" "1108.7" "1055.2" "1003.1" "1115.3" "722.8" "" "" "" "" "" "" "" "" "" "" "894.6" "774.2" "856.8" "643.0" "869.3" "946.3" "895.1" "726.0" "752.3" "722.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6550652705279003104" "False" "High" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "0.000" "False" "32.477" "22" "7" "10" "7" "380" "39.8" "8.94" "34.37" "7" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "Integrin-mediated cell adhesion; Focal adhesion" "5" "0" "0.917" "0.949" "1.062" "0.972" "0.960" "0.899" "0.919" "1.018" "3.120" "353.7" "324.5" "335.7" "375.7" "343.9" "339.6" "318.0" "324.9" "360.2" "1103.5" "" "" "" "" "" "" "" "" "" "" "319.3" "250.3" "259.6" "253.0" "286.9" "289.8" "269.7" "235.1" "242.9" "1103.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7900354501110065761" "False" "High" "IsMasterProtein" "O00170" "AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3" "0.000" "False" "32.474" "23" "7" "14" "7" "330" "37.6" "6.42" "33.93" "7" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "9049" "ENSG00000110711" "AIP" "A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; hsa:9049; O00170; Q2M3Q2; Q99606" "Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "5" "0" "0.934" "0.910" "1.002" "0.993" "0.879" "1.007" "0.787" "0.942" "2.028" "332.6" "310.7" "302.8" "333.3" "330.4" "292.3" "334.9" "261.7" "313.5" "674.5" "" "" "" "" "" "" "" "" "" "" "300.3" "239.6" "234.2" "224.4" "275.6" "249.5" "284.0" "189.4" "211.4" "674.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1056370544189754053" "False" "High" "IsMasterProtein" "P28065" "Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2" "0.000" "False" "32.466" "37" "6" "15" "6" "219" "23.3" "5.03" "44.38" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5698" "ENSG00000239836; ENSG00000240065; ENSG00000240118; ENSG00000240508; ENSG00000242711; ENSG00000243067; ENSG00000243594; ENSG00000243958" "PSMB9" "B0V0T1; hsa:5698; P28065; Q16523; Q5JNW4" "Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Type II interferon signaling" "61" "0" "0.959" "1.060" "1.070" "0.964" "1.045" "1.010" "1.010" "1.117" "0.747" "776.7" "744.6" "823.5" "831.0" "748.7" "811.7" "784.3" "784.3" "867.9" "580.0" "" "" "" "" "" "" "" "" "" "" "701.1" "574.3" "636.9" "559.6" "624.5" "692.8" "665.3" "567.6" "585.4" "580.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059296943260836861" "False" "High" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "0.000" "False" "32.396" "25" "5" "8" "3" "201" "23.0" "8.29" "27.94" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "" "3" "0" "0.993" "1.197" "0.954" "0.980" "1.258" "0.940" "1.071" "1.181" "0.870" "462.7" "459.7" "553.7" "441.5" "453.6" "582.0" "434.9" "495.4" "546.4" "402.4" "" "" "" "" "" "" "" "" "" "" "417.7" "354.6" "428.2" "297.3" "378.4" "496.8" "368.9" "358.5" "368.6" "402.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684590373995147366" "False" "High" "IsMasterProtein" "P35237" "Serpin B6 OS=Homo sapiens OX=9606 GN=SERPINB6 PE=1 SV=3" "0.000" "False" "32.390" "19" "6" "9" "6" "376" "42.6" "5.27" "22.74" "6" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5269" "ENSG00000124570" "SERPINB6" "B2RBA8; hsa:5269; P35237; Q59F97; Q5TD06; Q7Z2Y7; Q96J44; Q9UDI7" "Neutrophil degranulation; Dissolution of Fibrin Clot" "Ectoderm differentiation" "3" "0" "1.073" "1.074" "1.014" "1.135" "1.195" "1.139" "1.083" "1.232" "0.754" "226.1" "242.6" "242.8" "229.3" "256.6" "270.2" "257.5" "244.8" "278.5" "170.4" "" "" "" "" "" "" "" "" "" "" "204.1" "187.2" "187.8" "154.4" "214.0" "230.6" "218.4" "177.1" "187.8" "170.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4632135778776149030" "False" "High" "IsMasterProtein" "P18085" "ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3" "0.000" "False" "32.338" "30" "5" "14" "3" "180" "20.5" "7.14" "36.77" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00025" "378" "ENSG00000168374" "ARF4" "B2R7J7; hsa:378; P18085; P21371" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; VxPx cargo-targeting to cilium" "VEGFA-VEGFR2 signaling" "4" "0" "0.945" "0.885" "0.917" "0.980" "0.858" "1.013" "0.999" "0.858" "0.702" "275.1" "259.9" "243.4" "252.2" "269.4" "235.9" "278.7" "274.8" "235.9" "193.2" "" "" "" "" "" "" "" "" "" "" "248.3" "200.5" "188.2" "169.8" "224.8" "201.4" "236.4" "198.9" "159.1" "193.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5438538710980627953" "False" "High" "IsMasterProtein" "Q9H2C0" "Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1" "0.000" "False" "32.316" "14" "8" "10" "8" "597" "67.6" "5.85" "27.36" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "" "Pf00651, Pf01344, Pf07707" "8139" "ENSG00000261609" "GAN" "hsa:8139; Q9H2C0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.072" "1.128" "1.204" "1.104" "1.221" "1.134" "1.112" "1.152" "1.166" "729.1" "781.5" "822.4" "878.2" "804.8" "890.0" "826.8" "810.4" "839.7" "849.8" "" "" "" "" "" "" "" "" "" "" "658.1" "602.8" "636.0" "591.3" "671.3" "759.6" "701.4" "586.5" "566.3" "849.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181464862980127615" "False" "High" "IsMasterProtein" "Q13630" "GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=GFUS PE=1 SV=1" "0.000" "False" "32.314" "18" "5" "9" "5" "321" "35.9" "6.60" "30.10" "5" "cell adhesion;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01370" "7264" "ENSG00000104522; ENSG00000278243" "GFUS" "B2R8Y7; D3DWK5; hsa:7264; Q13630; Q567Q9; Q9UDG7" "GDP-fucose biosynthesis" "" "1" "0" "0.961" "0.998" "1.061" "0.995" "0.992" "0.960" "1.017" "1.053" "0.746" "531.4" "510.4" "530.4" "563.8" "528.8" "527.3" "510.3" "540.4" "559.3" "396.3" "" "" "" "" "" "" "" "" "" "" "479.7" "393.7" "410.2" "379.7" "441.1" "450.0" "432.9" "391.1" "377.2" "396.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819475231177228561" "False" "High" "IsMasterProtein" "O94966" "Ubiquitin carboxyl-terminal hydrolase 19 OS=Homo sapiens OX=9606 GN=USP19 PE=1 SV=2" "0.000" "False" "32.255" "6" "5" "5" "5" "1318" "145.6" "6.28" "20.96" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00443, Pf01753, Pf04969, Pf16602" "10869" "ENSG00000172046" "USP19" "A5PKX8; A6H8U2; B4DGT3; B4DTZ0; E7EN22; E7ETS0; E9PEG8; hsa:10869; O94966; Q3KQW4; Q641Q9; Q6NZY8; Q86XV9" "Ub-specific processing proteases" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "2" "0" "1.135" "0.968" "1.099" "1.133" "1.030" "1.051" "0.916" "0.972" "1.172" "121.6" "138.1" "117.8" "133.6" "137.8" "125.4" "127.9" "111.4" "118.2" "142.5" "" "" "" "" "" "" "" "" "" "" "109.8" "106.5" "91.1" "90.0" "115.0" "107.0" "108.5" "80.6" "79.7" "142.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4837224883862522345" "False" "High" "IsMasterProtein" "Q9BYD1" "Large ribosomal subunit protein uL13m OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" "0.000" "False" "32.224" "27" "5" "6" "5" "178" "20.7" "9.16" "26.06" "5" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00572" "28998" "ENSG00000172172" "MRPL13" "B2R4R8; hsa:28998; Q9BYD1; Q9UI04" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.025" "0.803" "1.007" "0.993" "0.725" "0.980" "0.835" "0.808" "0.863" "136.9" "140.3" "110.0" "138.0" "136.0" "99.2" "134.2" "114.4" "110.6" "118.2" "" "" "" "" "" "" "" "" "" "" "123.6" "108.2" "85.0" "92.9" "113.4" "84.7" "113.8" "82.8" "74.6" "118.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1716870644817082742" "False" "High" "IsMasterProtein" "Q15751" "Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2" "0.000" "False" "32.169" "2" "11" "13" "11" "4861" "531.9" "6.04" "33.01" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00415, Pf00622, Pf00632" "8925" "ENSG00000103657" "HERC1" "hsa:8925; Q15751; Q8IW65" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.013" "0.863" "1.022" "1.067" "0.932" "1.049" "1.032" "0.974" "1.158" "204.8" "207.5" "176.7" "209.3" "218.7" "191.0" "215.0" "211.4" "199.5" "237.2" "" "" "" "" "" "" "" "" "" "" "184.9" "160.1" "136.6" "141.0" "182.4" "163.0" "182.4" "153.0" "134.6" "237.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179215368678635356" "False" "High" "IsMasterProtein" "Q8IYB8" "ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1" "0.000" "False" "32.165" "10" "6" "8" "6" "786" "87.9" "7.99" "24.84" "6" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00271, Pf12513, Pf18114, Pf18147" "6832" "ENSG00000156502" "SUPV3L1" "A8K301; hsa:6832; O43630; Q8IYB8" "Mitochondrial RNA degradation" "" "1" "0" "1.028" "1.076" "1.109" "1.107" "1.034" "1.026" "1.023" "1.023" "0.912" "318.9" "327.9" "343.2" "353.5" "353.1" "329.8" "327.3" "326.2" "326.2" "290.9" "" "" "" "" "" "" "" "" "" "" "287.8" "252.9" "265.5" "238.1" "294.6" "281.5" "277.7" "236.0" "220.0" "290.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634047056467408227" "False" "High" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "0.000" "False" "32.140" "40" "3" "6" "3" "126" "13.9" "10.32" "26.83" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.026" "1.118" "0.833" "0.952" "1.139" "0.824" "1.009" "1.031" "0.856" "336.6" "345.3" "376.5" "280.4" "320.3" "383.5" "277.4" "339.6" "346.9" "288.3" "" "" "" "" "" "" "" "" "" "" "303.9" "266.3" "291.2" "188.8" "267.2" "327.4" "235.3" "245.8" "234.0" "288.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9007113237130658680" "False" "High" "IsMasterProtein" "O15498" "Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1" "0.000" "False" "32.094" "38" "8" "10" "8" "198" "22.4" "6.92" "34.18" "8" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "10652" "ENSG00000106636" "YKT6" "B4DR94; hsa:10652; O15498; Q53F01; Q6FGU9; Q6IB15" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport" "" "8" "0" "0.930" "0.998" "1.050" "1.033" "0.994" "0.972" "0.939" "1.005" "0.716" "1250.2" "1162.4" "1248.1" "1312.8" "1291.4" "1243.0" "1215.6" "1173.8" "1256.7" "895.0" "" "" "" "" "" "" "" "" "" "" "1128.6" "896.6" "965.3" "884.1" "1077.2" "1060.9" "1031.2" "849.5" "847.6" "895.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305466471512972771" "False" "High" "IsMasterProtein" "P0DMU9" "Cancer/testis antigen family 45 member A10 OS=Homo sapiens OX=9606 GN=CT45A10 PE=1 SV=1" "0.000" "False" "32.067" "27" "5" "11" "1" "189" "21.1" "9.55" "35.26" "5" "" "" "other molecular function" "Pf15300" "102723631" "ENSG00000269586" "CT45A10" "A8K842; B7ZMC5; hsa:102723631; P0DMU9; Q6NSH3" "" "" "0" "0" "0.907" "0.878" "0.716" "0.975" "0.840" "0.908" "0.881" "0.750" "0.789" "78.4" "71.2" "68.9" "56.2" "76.5" "65.9" "71.2" "69.1" "58.8" "61.9" "" "" "" "" "" "" "" "" "" "" "70.8" "54.9" "53.3" "37.8" "63.8" "56.2" "60.4" "50.0" "39.7" "61.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174444924925407144" "False" "High" "IsMasterProtein" "P61088" "Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1" "0.000" "False" "31.943" "35" "5" "15" "5" "152" "17.1" "6.57" "46.90" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7334" "ENSG00000177889" "UBE2N" "hsa:7334; P61088; Q16781; Q53Y81" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; Prader-Willi and Angelman syndrome; 3q29 copy number variation syndrome" "28" "0" "0.966" "1.014" "0.862" "0.875" "1.021" "0.943" "1.066" "0.848" "0.749" "923.9" "892.9" "936.6" "796.2" "808.0" "943.4" "871.1" "984.8" "783.2" "691.7" "" "" "" "" "" "" "" "" "" "" "834.0" "688.8" "724.4" "536.1" "674.0" "805.2" "739.0" "712.7" "528.3" "691.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5348588292702008792" "False" "High" "IsMasterProtein" "O94888" "UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2" "0.000" "False" "31.859" "15" "8" "11" "8" "489" "54.8" "5.16" "34.50" "8" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf13899, Pf14555" "26043" "ENSG00000163960" "UBXN7" "D3DXB3; hsa:26043; O94888; Q6ZP77; Q86X20; Q8N327" "Neddylation; KEAP1-NFE2L2 pathway" "3q29 copy number variation syndrome" "3" "0" "0.968" "0.862" "1.010" "0.992" "0.931" "1.034" "0.897" "0.981" "0.871" "454.3" "440.0" "391.4" "458.7" "450.8" "422.9" "469.8" "407.6" "445.8" "395.6" "" "" "" "" "" "" "" "" "" "" "410.1" "339.4" "302.7" "308.9" "376.0" "360.9" "398.5" "295.0" "300.7" "395.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652533075202528091" "False" "High" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "0.000" "False" "31.818" "17" "5" "11" "5" "400" "43.4" "5.10" "33.86" "5" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport" "" "2" "0" "1.025" "1.031" "0.931" "1.013" "1.220" "1.011" "1.077" "1.112" "1.104" "278.9" "286.0" "287.6" "259.7" "282.6" "340.4" "282.1" "300.4" "310.2" "308.0" "" "" "" "" "" "" "" "" "" "" "251.8" "220.6" "222.4" "174.9" "235.7" "290.5" "239.3" "217.4" "209.3" "308.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6610589870849209696" "False" "High" "IsMasterProtein" "Q9NZ63" "Splicing factor C9orf78 OS=Homo sapiens OX=9606 GN=C9orf78 PE=1 SV=1" "0.000" "False" "31.801" "19" "5" "8" "5" "289" "33.7" "6.74" "28.54" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07052" "51759" "ENSG00000136819" "C9orf78" "B3KPX8; Q8WVU6; Q9NT39; Q9NZ63" "mRNA Splicing - Major Pathway" "" "1" "0" "1.031" "1.031" "0.998" "1.008" "1.047" "0.951" "1.040" "1.051" "0.780" "589.4" "607.4" "607.8" "588.1" "593.9" "616.9" "560.5" "612.9" "619.2" "459.4" "" "" "" "" "" "" "" "" "" "" "532.0" "468.5" "470.1" "396.0" "495.4" "526.5" "475.5" "443.6" "417.6" "459.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3647581331953333811" "False" "High" "IsMasterProtein" "Q658Y4" "Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3" "0.000" "False" "31.796" "8" "7" "10" "7" "838" "93.9" "6.39" "31.75" "7" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf14647, Pf14648" "157769" "ENSG00000176853" "FAM91A1" "B6YY23; hsa:157769; Q658T5; Q658Y4; Q8TE89" "RHOH GTPase cycle" "Gastric cancer network 2" "2" "0" "0.974" "0.997" "0.963" "0.997" "0.883" "1.071" "1.048" "0.941" "0.909" "344.5" "335.5" "343.5" "331.7" "343.6" "304.4" "369.1" "361.0" "324.4" "313.0" "" "" "" "" "" "" "" "" "" "" "311.0" "258.8" "265.7" "223.4" "286.6" "259.8" "313.1" "261.3" "218.8" "313.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2309568012740462624" "False" "High" "IsMasterProtein" "Q02750" "Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2" "0.000" "False" "31.782" "11" "6" "10" "4" "393" "43.4" "6.62" "30.20" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5604" "ENSG00000169032" "MAP2K1" "hsa:5604; Q02750" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAP3K8 (TPL2)-dependent MAPK1/3 activation; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "102" "0" "0.990" "0.784" "1.015" "0.981" "0.750" "1.019" "1.007" "0.770" "0.702" "344.2" "340.8" "269.8" "349.3" "337.7" "258.1" "350.7" "346.5" "265.2" "241.7" "" "" "" "" "" "" "" "" "" "" "310.7" "262.9" "208.7" "235.2" "281.7" "220.3" "297.5" "250.8" "178.9" "241.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1785172786280045072" "False" "High" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "0.000" "False" "31.765" "27" "5" "10" "5" "217" "25.1" "6.15" "31.93" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "33" "0" "1.066" "1.153" "0.978" "1.103" "1.135" "1.107" "0.972" "1.162" "1.335" "524.1" "558.7" "604.5" "512.6" "577.9" "594.6" "580.3" "509.5" "609.1" "699.8" "" "" "" "" "" "" "" "" "" "" "473.1" "430.9" "467.5" "345.2" "482.1" "507.5" "492.3" "368.7" "410.8" "699.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271968905262141895" "False" "High" "IsMasterProtein" "Q4VC31" "Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1" "0.000" "False" "31.705" "30" "4" "11" "4" "144" "16.6" "7.81" "35.36" "4" "" "mitochondrion" "" "Pf09774" "131076" "ENSG00000160124" "MIX23" "hsa:131076; Q32LY6; Q4VC31" "" "" "0" "0" "0.939" "1.054" "0.929" "0.887" "0.945" "0.950" "1.102" "0.938" "0.627" "925.1" "868.8" "975.5" "859.4" "820.9" "874.2" "878.8" "1019.4" "868.2" "580.2" "" "" "" "" "" "" "" "" "" "" "835.1" "670.1" "754.5" "578.7" "684.8" "746.2" "745.5" "737.7" "585.6" "580.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792882720935006206" "False" "High" "IsMasterProtein" "Q9HAV4" "Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1" "0.000" "False" "31.649" "6" "5" "8" "5" "1204" "136.2" "5.80" "22.75" "5" "RNA metabolism OR transcription;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19273" "57510" "ENSG00000124571" "XPO5" "hsa:57510; Q5JTE6; Q96G48; Q96HN3; Q9BWM6; Q9BZV5; Q9H9M4; Q9HAV4; Q9NT89; Q9NW39; Q9ULC9" "MicroRNA (miRNA) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Primary ovarian insufficiency" "4" "0" "0.994" "0.972" "1.053" "1.043" "0.906" "1.093" "1.003" "1.058" "2.584" "368.9" "366.5" "358.4" "388.5" "384.8" "334.3" "403.3" "370.1" "390.4" "953.1" "" "" "" "" "" "" "" "" "" "" "333.0" "282.7" "277.2" "261.6" "321.0" "285.3" "342.1" "267.8" "263.3" "953.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5667017434232915728" "False" "High" "IsMasterProtein" "Q9Y618" "Nuclear receptor corepressor 2 OS=Homo sapiens OX=9606 GN=NCOR2 PE=1 SV=3" "0.000" "False" "31.626" "4" "8" "9" "7" "2514" "273.5" "7.59" "24.34" "8" "transport;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9612" "ENSG00000196498" "NCOR2" "hsa:9612; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; Q9Y618" "Cytoprotection by HMOX1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; SUMOylation of transcription cofactors; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; HDACs deacetylate histones; Nuclear Receptor transcription pathway; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "Androgen receptor signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Notch signaling; Rett syndrome; Notch signaling pathway" "23" "0" "1.046" "1.046" "1.013" "1.030" "1.004" "1.013" "1.039" "1.125" "1.051" "293.4" "306.8" "306.8" "297.1" "302.1" "294.6" "297.1" "304.9" "330.0" "308.4" "" "" "" "" "" "" "" "" "" "" "264.8" "236.6" "237.3" "200.1" "252.0" "251.4" "252.1" "220.6" "222.6" "308.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3934264021141742446" "False" "High" "IsMasterProtein" "Q9UI12" "V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1" "0.000" "False" "31.603" "17" "8" "10" "8" "483" "55.8" "6.48" "27.48" "8" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity;enzyme regulator activity" "Pf03224, Pf11698" "51606" "ENSG00000047249" "ATP6V1H" "B3KMR0; hsa:51606; Q6PK44; Q9H3E3; Q9UI12; Q9Y300" "ROS and RNS production in phagocytes; Nef Mediated CD4 Down-regulation; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; Nef Mediated CD8 Down-regulation; Blockage of phagosome acidification" "Proximal tubule transport" "9" "0" "0.987" "0.925" "0.905" "1.007" "0.987" "1.004" "0.873" "0.961" "0.955" "422.6" "417.1" "391.1" "382.4" "425.6" "416.9" "424.3" "369.1" "406.2" "403.6" "" "" "" "" "" "" "" "" "" "" "381.5" "321.7" "302.5" "257.5" "355.0" "355.8" "359.9" "267.1" "274.0" "403.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5464068146291938331" "False" "High" "IsMasterProtein" "P49840" "Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2" "0.000" "False" "31.572" "10" "5" "6" "2" "483" "50.9" "8.75" "24.09" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2931" "ENSG00000105723" "GSK3A" "hsa:2931; O14959; P49840" "Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein" "IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation; HDAC6 interactions in the central nervous system" "18" "0" "1.023" "0.924" "1.033" "0.965" "0.909" "1.081" "1.034" "0.951" "0.756" "231.3" "236.5" "213.6" "239.0" "223.1" "210.3" "249.9" "239.0" "219.9" "174.8" "" "" "" "" "" "" "" "" "" "" "208.8" "182.4" "165.2" "160.9" "186.1" "179.5" "212.0" "173.0" "148.3" "174.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7082716862048425116" "False" "High" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "0.000" "False" "31.557" "9" "7" "8" "7" "1015" "114.3" "5.59" "24.31" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "Condensation of Prometaphase Chromosomes" "" "1" "0" "1.044" "0.845" "1.020" "0.895" "0.857" "0.924" "0.715" "0.897" "4.547" "199.5" "208.1" "168.5" "203.4" "178.6" "170.9" "184.4" "142.7" "178.9" "906.9" "" "" "" "" "" "" "" "" "" "" "180.0" "160.5" "130.4" "137.0" "149.0" "145.9" "156.4" "103.3" "120.7" "906.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8157399823022384529" "False" "High" "IsMasterProtein" "Q99567" "Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2" "0.000" "False" "31.517" "13" "8" "8" "8" "741" "83.5" "5.69" "28.01" "8" "other metabolic processes;transport" "cytosol;nucleus" "other molecular function" "Pf10168" "4927" "ENSG00000108559" "NUP88" "D3DTM2; hsa:4927; Q99567; Q9BWE5" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "Ciliary landscape" "29" "0" "0.979" "0.782" "0.870" "0.948" "0.948" "0.848" "0.849" "0.791" "1.747" "325.9" "319.1" "254.8" "283.5" "308.9" "309.0" "276.2" "276.6" "257.6" "569.4" "" "" "" "" "" "" "" "" "" "" "294.2" "246.1" "197.1" "190.9" "257.6" "263.8" "234.3" "200.2" "173.8" "569.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "677526654360538548" "False" "High" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "0.000" "False" "31.434" "16" "5" "15" "4" "375" "42.8" "4.69" "37.72" "5" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "0" "1.009" "0.982" "1.054" "0.964" "0.953" "1.001" "0.932" "0.991" "0.778" "933.3" "941.4" "916.7" "983.4" "900.0" "889.1" "934.2" "870.2" "925.2" "726.1" "" "" "" "" "" "" "" "" "" "" "842.5" "726.1" "709.0" "662.2" "750.7" "758.9" "792.4" "629.7" "624.0" "726.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7020268087964795198" "False" "High" "IsMasterProtein" "Q9Y3B7" "Large ribosomal subunit protein uL11m OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "0.000" "False" "31.421" "27" "4" "5" "4" "192" "20.7" "9.91" "17.02" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.008" "0.777" "1.077" "1.098" "0.742" "1.058" "1.002" "0.788" "1.232" "117.7" "118.7" "91.5" "126.8" "129.3" "87.4" "124.6" "117.9" "92.7" "145.1" "" "" "" "" "" "" "" "" "" "" "106.3" "91.5" "70.8" "85.4" "107.9" "74.6" "105.7" "85.4" "62.6" "145.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3259776130493618651" "False" "High" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "0.000" "False" "31.417" "13" "9" "12" "9" "645" "73.5" "8.02" "36.08" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.094" "0.808" "1.090" "1.055" "0.872" "1.039" "1.024" "0.844" "0.750" "674.4" "738.1" "545.2" "735.1" "711.2" "588.3" "700.5" "690.7" "569.0" "505.9" "" "" "" "" "" "" "" "" "" "" "608.7" "569.3" "421.6" "495.0" "593.2" "502.1" "594.2" "499.8" "383.8" "505.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905591351439676835" "False" "High" "IsMasterProtein" "P50995" "Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1" "0.000" "False" "31.400" "15" "7" "10" "7" "505" "54.4" "7.65" "25.29" "7" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00191" "311" "ENSG00000122359" "ANXA11" "B4DVE7; hsa:311; P50995" "" "" "0" "0" "0.846" "1.121" "0.957" "0.954" "0.897" "0.933" "0.893" "1.053" "2.842" "616.8" "521.6" "691.5" "590.4" "588.4" "553.3" "575.2" "551.1" "649.8" "1752.9" "" "" "" "" "" "" "" "" "" "" "556.8" "402.3" "534.8" "397.6" "490.8" "472.3" "488.0" "398.8" "438.3" "1752.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200038646673232615" "False" "High" "IsMasterProtein" "Q9P287" "BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1" "0.000" "False" "31.388" "19" "5" "6" "5" "314" "36.0" "4.61" "22.84" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;cytoskeletal activity" "Pf13862" "56647" "ENSG00000107949" "BCCIP" "B3KP45; hsa:56647; Q8ND15; Q96GC4; Q9P287; Q9P288" "" "" "0" "0" "0.953" "0.896" "0.982" "0.993" "0.958" "0.960" "1.001" "0.925" "0.834" "249.4" "237.6" "223.5" "244.9" "247.7" "238.8" "239.3" "249.7" "230.7" "207.9" "" "" "" "" "" "" "" "" "" "" "225.1" "183.3" "172.9" "164.9" "206.6" "203.8" "203.0" "180.7" "155.6" "207.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1264593624988505849" "False" "High" "IsMasterProtein" "Q14694" "Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2" "0.000" "False" "31.384" "11" "7" "8" "7" "798" "87.1" "5.31" "26.48" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf07145" "9100" "ENSG00000103194" "USP10" "B2RDJ8; B4DS84; hsa:9100; Q14694; Q9BWG7; Q9NSL7" "Ub-specific processing proteases; Termination of translesion DNA synthesis" "VEGFA-VEGFR2 signaling" "3" "0" "0.914" "1.163" "0.995" "1.003" "1.129" "0.976" "0.895" "1.240" "1.130" "462.2" "422.4" "537.4" "459.7" "463.7" "521.9" "451.0" "413.7" "573.2" "522.2" "" "" "" "" "" "" "" "" "" "" "417.2" "325.8" "415.6" "309.6" "386.8" "445.4" "382.5" "299.4" "386.6" "522.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546315403352841289" "False" "High" "IsMasterProtein" "Q9Y2B0" "Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1" "0.000" "False" "31.378" "26" "4" "8" "4" "182" "20.6" "4.92" "30.96" "4" "other biological processes" "ER/Golgi" "" "Pf11938" "10330" "ENSG00000257727" "CNPY2" "B2R7B9; Q9UHE9; Q9Y2B0" "" "" "0" "0" "0.999" "1.173" "1.055" "0.955" "1.128" "1.034" "1.104" "1.175" "0.806" "385.1" "384.6" "451.8" "406.3" "367.9" "434.4" "398.3" "425.2" "452.6" "310.2" "" "" "" "" "" "" "" "" "" "" "347.6" "296.6" "349.4" "273.6" "306.9" "370.8" "337.8" "307.7" "305.3" "310.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1038572201038202760" "False" "High" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "0.000" "False" "31.328" "32" "3" "10" "3" "100" "10.7" "9.60" "39.30" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "1.030" "1.305" "0.992" "0.924" "1.073" "1.061" "1.067" "1.239" "0.757" "1321.1" "1361.0" "1724.4" "1310.2" "1220.5" "1417.9" "1402.3" "1409.6" "1637.3" "1000.2" "" "" "" "" "" "" "" "" "" "" "1192.5" "1049.8" "1333.7" "882.3" "1018.1" "1210.2" "1189.5" "1020.1" "1104.4" "1000.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2210442272290705579" "False" "High" "IsMasterProtein" "P09493" "Tropomyosin alpha-1 chain OS=Homo sapiens OX=9606 GN=TPM1 PE=1 SV=2" "0.000" "False" "31.259" "17" "5" "21" "1" "284" "32.7" "4.74" "65.94" "5" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00261" "7168" "ENSG00000140416" "TPM1" "B7Z5T7; D9YZV2; D9YZV3; D9YZV8; hsa:7168; P09493; P09494; P10469; Q6DV89; Q6DV90; Q7Z6L8; Q86W64; Q96IK2; Q9UCI1; Q9UCI2; Q9UCY9; Q9Y427" "Smooth Muscle Contraction; Striated Muscle Contraction" "Vitamin D receptor pathway; Striated muscle contraction pathway; Cell lineage map for neuronal differentiation" "5" "0" "0.892" "1.088" "1.035" "0.945" "1.095" "0.976" "1.067" "1.055" "0.777" "99.3" "88.6" "108.0" "102.7" "93.8" "108.7" "96.9" "106.0" "104.8" "77.2" "" "" "" "" "" "" "" "" "" "" "89.6" "68.3" "83.5" "69.2" "78.2" "92.8" "82.2" "76.7" "70.7" "77.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6086246065885053041" "False" "High" "IsMasterProtein" "Cont_P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "0.000" "True" "31.252" "21" "10" "15" "7" "472" "51.5" "5.16" "32.64" "10" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Formation of the cornified envelope; Type I hemidesmosome assembly" "Corticotropin-releasing hormone signaling pathway" "4" "0" "0.576" "0.614" "0.979" "0.409" "0.433" "0.440" "0.644" "0.598" "0.500" "297.2" "171.2" "182.5" "290.9" "121.4" "128.8" "130.7" "191.5" "177.6" "148.5" "" "" "" "" "" "" "" "" "" "" "268.3" "132.0" "141.2" "195.9" "101.3" "109.9" "110.9" "138.6" "119.8" "148.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073830227573610312" "False" "High" "IsMasterProtein" "Q9NR45" "Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2" "0.000" "False" "31.252" "18" "6" "12" "6" "359" "40.3" "6.74" "37.19" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03102, Pf08666" "54187" "ENSG00000095380" "NANS" "B2RE98; Q8WUV9; Q9BWS6; Q9NR45; Q9NVD4" "Sialic acid metabolism" "Sialylation" "2" "0" "1.110" "1.018" "0.964" "1.065" "1.149" "1.033" "1.131" "1.076" "1.071" "539.0" "598.4" "548.6" "519.4" "574.3" "619.2" "557.1" "609.6" "579.9" "577.2" "" "" "" "" "" "" "" "" "" "" "486.6" "461.6" "424.3" "349.8" "479.1" "528.5" "472.6" "441.2" "391.1" "577.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758380383998066899" "False" "High" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "0.000" "False" "31.215" "14" "3" "8" "3" "257" "26.9" "11.15" "32.18" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "mRNA Splicing - Major Pathway; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "7" "0" "1.035" "2.167" "1.060" "1.085" "1.944" "1.051" "1.052" "1.995" "0.984" "345.8" "358.0" "749.2" "366.7" "375.3" "672.2" "363.3" "363.8" "689.8" "340.2" "" "" "" "" "" "" "" "" "" "" "312.1" "276.2" "579.5" "246.9" "313.1" "573.8" "308.1" "263.3" "465.3" "340.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857038607970442570" "False" "High" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "0.000" "False" "31.202" "16" "6" "20" "6" "314" "34.3" "8.85" "54.89" "6" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Mitochondrial protein degradation; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "12" "0" "0.986" "0.976" "0.930" "0.928" "0.947" "0.926" "0.954" "0.950" "0.642" "1882.8" "1855.9" "1837.8" "1750.5" "1747.6" "1783.0" "1743.8" "1796.5" "1788.9" "1208.4" "" "" "" "" "" "" "" "" "" "" "1699.5" "1431.5" "1421.4" "1178.8" "1457.8" "1521.8" "1479.2" "1300.1" "1206.6" "1208.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6508547570803101910" "False" "High" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "0.000" "False" "31.198" "32" "9" "10" "7" "270" "31.8" "6.55" "28.44" "9" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "" "2" "2" "1.000" "1.052" "1.014" "0.930" "1.016" "0.984" "0.924" "1.077" "0.699" "962.7" "962.2" "1012.4" "976.4" "895.5" "978.3" "947.7" "889.5" "1036.7" "672.8" "" "" "" "" "" "" "" "" "" "" "869.0" "742.2" "783.0" "657.5" "747.0" "835.0" "803.9" "643.7" "699.2" "672.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5965687288212214297" "False" "High" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "0.000" "False" "31.195" "13" "4" "7" "4" "374" "42.5" "5.63" "25.12" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "" "6" "0" "1.007" "0.861" "1.014" "1.027" "0.918" "1.084" "0.861" "0.976" "3.250" "257.0" "258.7" "221.2" "260.7" "263.9" "235.8" "278.5" "221.3" "250.9" "835.2" "" "" "" "" "" "" "" "" "" "" "232.0" "199.5" "171.1" "175.5" "220.1" "201.3" "236.2" "160.2" "169.2" "835.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4145241579063427930" "False" "High" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "0.000" "False" "31.093" "20" "7" "10" "7" "391" "45.1" "7.74" "27.55" "7" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "22" "0" "1.005" "1.002" "1.045" "1.040" "1.131" "0.982" "0.895" "1.080" "1.094" "350.2" "352.1" "351.1" "366.1" "364.2" "396.0" "343.8" "313.3" "378.3" "383.1" "" "" "" "" "" "" "" "" "" "" "316.1" "271.6" "271.5" "246.5" "303.8" "338.0" "291.7" "226.7" "255.2" "383.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100436114582122401" "False" "High" "IsMasterProtein" "Q93034" "Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4" "0.000" "False" "31.069" "10" "9" "9" "9" "780" "90.9" "7.94" "27.87" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf00888, Pf10557" "8065" "ENSG00000166266" "CUL5" "A8K960; O14766; Q93034; Q9BZC6" "Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Downregulation of ERBB2 signaling; Evasion by RSV of host interferon responses" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation; 10q11.21q11.23 copy number variation syndrome" "10" "0" "1.005" "0.919" "1.015" "0.974" "0.987" "0.928" "0.993" "0.996" "0.825" "680.8" "684.0" "625.3" "691.3" "662.9" "672.2" "631.4" "676.0" "677.7" "561.6" "" "" "" "" "" "" "" "" "" "" "614.5" "527.6" "483.7" "465.5" "553.0" "573.8" "535.6" "489.2" "457.1" "561.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5070657134179306573" "False" "High" "IsMasterProtein" "P55160" "Nck-associated protein 1-like OS=Homo sapiens OX=9606 GN=NCKAP1L PE=1 SV=3" "0.000" "False" "31.050" "9" "9" "9" "9" "1127" "128.1" "6.86" "26.50" "9" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf09735" "3071" "ENSG00000123338" "NCKAP1L" "B4DUT5; hsa:3071; P55160; Q52LW0" "Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "Hematopoietic stem cell differentiation; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia" "11" "0" "0.961" "0.810" "0.889" "0.908" "0.771" "0.935" "0.925" "0.802" "1.116" "719.0" "690.8" "582.3" "639.5" "653.0" "554.6" "672.0" "665.0" "576.5" "802.4" "" "" "" "" "" "" "" "" "" "" "649.0" "532.9" "450.4" "430.6" "544.7" "473.4" "570.0" "481.3" "388.8" "802.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254459010250463691" "False" "High" "IsMasterProtein" "Cont_Q3ZBD7" "Glucose-6-phosphate isomerase OS=Bos taurus OX=9913 GN=GPI PE=2 SV=4" "0.000" "True" "31.046" "13" "5" "12" "1" "557" "62.8" "7.71" "44.98" "5" "other metabolic processes;signal transduction" "non-structural extracellular;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "104995211; 109572099; 280808" "ENSBTAG00000006396" "GPI" "A0A6B0R509; A0A6P3HXC3; A0A6P5DB13; biu:109572099; bta:280808; F1MD19; O46595; Q3ZBD7" "TP53 Regulates Metabolic Genes; Neutrophil degranulation; Gluconeogenesis; Glycolysis" "Glycolysis and gluconeogenesis; Cori cycle" "6" "0" "1.041" "0.803" "0.951" "1.081" "1.122" "1.180" "0.849" "0.880" "0.942" "38.8" "40.4" "31.2" "36.9" "42.0" "43.6" "45.8" "33.0" "34.2" "36.6" "" "" "" "" "" "" "" "" "" "" "35.0" "31.2" "24.1" "24.9" "35.0" "37.2" "38.9" "23.8" "23.0" "36.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4989435524198560061" "False" "High" "IsMasterProtein" "P48506" "Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2" "0.000" "False" "30.992" "10" "6" "10" "5" "637" "72.7" "6.09" "30.75" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03074" "2729" "ENSG00000001084" "GCLC" "hsa:2729; P48506; Q14399" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "17" "1" "1.099" "0.891" "1.009" "0.961" "0.971" "0.960" "0.929" "0.958" "0.859" "281.7" "309.7" "250.9" "284.2" "270.7" "273.6" "270.5" "261.7" "269.9" "242.1" "" "" "" "" "" "" "" "" "" "" "254.3" "238.9" "194.1" "191.4" "225.8" "233.5" "229.5" "189.4" "182.0" "242.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7014036665860809700" "False" "High" "IsMasterProtein" "Q13459" "Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3" "0.000" "False" "30.939" "5" "8" "8" "8" "2157" "243.2" "8.75" "22.29" "8" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf00620, Pf00788" "4650" "ENSG00000099331" "MYO9B" "hsa:4650; O75314; Q13459; Q9NUJ2; Q9UHN0" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOA GTPase cycle; RAC1 GTPase cycle; RHOC GTPase cycle; CDC42 GTPase cycle; RHOB GTPase cycle; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity" "Vitamin D receptor pathway" "10" "0" "1.058" "0.999" "1.052" "1.060" "0.944" "1.016" "0.934" "0.952" "1.969" "443.9" "469.4" "443.4" "466.9" "470.6" "419.1" "450.8" "414.4" "422.7" "874.0" "" "" "" "" "" "" "" "" "" "" "400.7" "362.1" "342.9" "314.4" "392.6" "357.7" "382.4" "299.9" "285.1" "874.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3455107625301328378" "False" "High" "IsMasterProtein" "Q86TX2" "Acyl-coenzyme A thioesterase 1 OS=Homo sapiens OX=9606 GN=ACOT1 PE=1 SV=1" "0.000" "False" "30.930" "15" "7" "8" "7" "421" "46.2" "7.34" "23.92" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf04775, Pf08840" "641371" "ENSG00000184227" "ACOT1" "A1L173; hsa:641371; Q3I5F9; Q86TX2" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "1.061" "1.064" "1.034" "1.090" "1.159" "1.006" "0.959" "1.174" "0.966" "404.1" "428.6" "429.9" "418.0" "440.4" "468.2" "406.7" "387.5" "474.4" "390.5" "" "" "" "" "" "" "" "" "" "" "364.8" "330.6" "332.5" "281.5" "367.3" "399.7" "345.0" "280.4" "320.0" "390.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1738440604026587204" "False" "High" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "0.000" "False" "30.930" "19" "4" "9" "3" "307" "35.1" "5.06" "30.34" "4" "DNA metabolism;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "Processing of DNA double-strand break ends" "16p11.2 proximal deletion syndrome" "2" "0" "0.975" "0.934" "1.111" "1.018" "1.003" "1.104" "1.087" "1.019" "0.788" "132.5" "129.2" "123.7" "147.2" "134.8" "132.9" "146.2" "143.9" "135.0" "104.4" "" "" "" "" "" "" "" "" "" "" "119.6" "99.6" "95.7" "99.1" "112.5" "113.4" "124.0" "104.2" "91.0" "104.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3716051439609727834" "False" "High" "IsMasterProtein" "Q9NW82" "WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1" "0.000" "False" "30.900" "7" "5" "7" "5" "654" "73.2" "6.33" "25.55" "5" "" "nucleus;other cell component" "other molecular function" "Pf00400" "55100" "ENSG00000082068" "WDR70" "hsa:55100; Q9H053; Q9NW82" "mRNA Splicing - Major Pathway" "" "1" "0" "1.047" "0.848" "0.951" "0.983" "0.905" "1.000" "1.013" "0.955" "0.887" "384.0" "402.2" "325.6" "365.4" "377.5" "347.5" "384.0" "388.9" "366.6" "340.7" "" "" "" "" "" "" "" "" "" "" "346.6" "310.2" "251.9" "246.1" "314.9" "296.6" "325.8" "281.4" "247.3" "340.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8434101151437963191" "False" "High" "IsMasterProtein" "Q7Z2K8" "G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2" "0.000" "False" "30.891" "11" "12" "13" "12" "1008" "102.3" "8.06" "36.32" "12" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf15235" "114787" "ENSG00000169258" "GPRIN1" "C9JM70; hsa:114787; Q7Z2K8; Q8ND74; Q96PZ4" "MECP2 regulates neuronal receptors and channels" "MECP2 and associated Rett syndrome; 5q35 copy number variation" "3" "0" "0.932" "1.111" "1.199" "0.910" "1.017" "0.960" "1.038" "1.086" "0.748" "668.5" "622.8" "742.4" "801.2" "608.3" "679.6" "641.8" "693.7" "726.1" "499.8" "" "" "" "" "" "" "" "" "" "" "603.4" "480.4" "574.2" "539.5" "507.4" "580.1" "544.4" "502.0" "489.8" "499.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676501743634657271" "False" "High" "IsMasterProtein" "P40855" "Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1" "0.000" "False" "30.856" "19" "5" "6" "5" "299" "32.8" "4.34" "21.96" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04614" "5824" "ENSG00000162735" "PEX19" "D3DVE7; E9PPB4; G3V3G9; hsa:5824; P40855; Q5QNY4; Q8NI97" "Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "TAR syndrome" "3" "0" "0.888" "0.895" "0.891" "0.960" "0.910" "0.867" "1.054" "0.871" "0.679" "678.4" "602.3" "606.9" "604.2" "651.1" "617.3" "587.8" "715.1" "590.9" "460.5" "" "" "" "" "" "" "" "" "" "" "612.3" "464.6" "469.4" "406.9" "543.1" "526.9" "498.6" "517.5" "398.6" "460.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4596787228496680093" "False" "High" "IsMasterProtein" "Q9BV86" "N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3" "0.000" "False" "30.823" "22" "3" "5" "3" "223" "25.4" "5.52" "21.71" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05891" "28989" "ENSG00000148335" "NTMT1" "A8K4J2; A8K8G7; hsa:28989; Q5SZB9; Q9BV86; Q9UI28" "" "" "0" "0" "1.028" "0.696" "0.988" "1.018" "0.741" "0.985" "0.948" "0.675" "0.982" "80.2" "82.4" "55.8" "79.3" "81.7" "59.4" "79.0" "76.0" "54.2" "78.8" "" "" "" "" "" "" "" "" "" "" "72.4" "63.6" "43.2" "53.4" "68.1" "50.7" "67.0" "55.0" "36.5" "78.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2555536461123867922" "False" "High" "IsMasterProtein" "Q86U90" "Threonylcarbamoyl-AMP synthase OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1" "0.000" "False" "30.806" "18" "4" "7" "4" "279" "29.3" "8.57" "25.59" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01300" "79693" "ENSG00000196449" "YRDC" "hsa:79693; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q86U90; Q9H5F8" "" "" "0" "0" "0.901" "0.770" "0.926" "0.945" "0.795" "0.919" "0.923" "0.762" "0.716" "177.2" "159.7" "136.5" "164.0" "167.4" "140.9" "162.8" "163.5" "135.0" "126.8" "" "" "" "" "" "" "" "" "" "" "160.0" "123.2" "105.6" "110.4" "139.6" "120.3" "138.1" "118.3" "91.1" "126.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6258947584785222358" "False" "High" "IsMasterProtein" "P62906" "Large ribosomal subunit protein uL1 OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "0.000" "False" "30.803" "26" "5" "8" "5" "217" "24.8" "9.94" "23.26" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.858" "1.100" "0.816" "0.991" "1.015" "0.966" "1.082" "0.985" "0.306" "433.1" "371.8" "476.4" "353.6" "429.1" "439.5" "418.3" "468.8" "426.8" "132.6" "" "" "" "" "" "" "" "" "" "" "391.0" "286.8" "368.5" "238.1" "357.9" "375.1" "354.9" "339.3" "287.9" "132.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6470269132294442760" "False" "High" "IsMasterProtein" "Q8WUM0" "Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2" "0.000" "False" "30.799" "8" "9" "12" "9" "1156" "128.9" "5.10" "28.50" "9" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03177" "55746" "ENSG00000069248" "NUP133" "B2RAZ8; hsa:55746; Q5T8N0; Q8WUM0; Q9H9W2; Q9NV71; Q9NVC4" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; ISG15 antiviral mechanism; Regulation of HSF1-mediated heat shock response; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Early Events; tRNA processing in the nucleus; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "Ciliary landscape" "36" "0" "1.007" "0.789" "0.968" "1.053" "0.881" "0.939" "1.038" "0.840" "1.085" "814.2" "820.1" "642.3" "788.4" "857.4" "717.7" "764.3" "844.9" "684.1" "883.5" "" "" "" "" "" "" "" "" "" "" "734.9" "632.6" "496.8" "530.9" "715.2" "612.5" "648.4" "611.4" "461.4" "883.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133999276561542569" "False" "High" "IsMasterProtein" "Q86X55" "Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3" "0.000" "False" "30.760" "13" "8" "15" "8" "608" "65.8" "6.73" "46.18" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06325, Pf11531" "10498" "ENSG00000142453" "CARM1" "A6NN38; hsa:10498; Q86X55" "Estrogen-dependent gene expression; RMTs methylate histone arginines; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression" "Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis" "15" "0" "0.963" "0.891" "0.873" "0.967" "0.889" "1.018" "1.024" "0.880" "0.729" "1024.0" "986.3" "912.5" "894.4" "990.2" "910.0" "1042.3" "1048.3" "900.9" "746.9" "" "" "" "" "" "" "" "" "" "" "924.4" "760.8" "705.8" "602.3" "826.0" "776.7" "884.1" "758.6" "607.6" "746.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5859818642723021868" "False" "High" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "0.000" "False" "30.757" "11" "6" "8" "6" "583" "66.7" "5.11" "25.63" "6" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "1.002" "0.922" "0.968" "1.038" "0.924" "1.007" "1.076" "0.955" "1.037" "508.9" "510.0" "469.4" "492.8" "528.5" "470.2" "512.3" "547.8" "486.0" "527.7" "" "" "" "" "" "" "" "" "" "" "459.4" "393.4" "363.1" "331.8" "440.9" "401.3" "434.5" "396.5" "327.8" "527.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6973365880698085835" "False" "High" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "0.000" "False" "30.751" "12" "7" "12" "7" "586" "65.4" "8.97" "41.61" "7" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "0.981" "1.029" "1.057" "0.955" "0.988" "0.988" "0.967" "0.982" "0.684" "748.5" "734.1" "770.1" "790.8" "714.9" "739.4" "739.6" "723.5" "735.3" "512.2" "" "" "" "" "" "" "" "" "" "" "675.6" "566.2" "595.6" "532.5" "596.3" "631.1" "627.4" "523.6" "496.0" "512.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8650097818779685703" "False" "High" "IsMasterProtein" "P62857" "Small ribosomal subunit protein eS28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "0.000" "False" "30.743" "46" "3" "29" "3" "69" "7.8" "10.70" "72.13" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.963" "1.085" "1.137" "1.001" "0.993" "0.984" "0.989" "1.122" "0.595" "815.2" "785.0" "884.4" "926.9" "815.7" "809.9" "802.2" "806.0" "914.8" "485.5" "" "" "" "" "" "" "" "" "" "" "735.9" "605.5" "684.0" "624.1" "680.4" "691.2" "680.5" "583.3" "617.0" "485.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5102173735616793815" "False" "High" "IsMasterProtein" "Q9BWH6" "RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3" "0.000" "False" "30.693" "7" "8" "9" "8" "1393" "152.7" "6.38" "28.79" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08620, Pf08621" "26015" "ENSG00000103932" "RPAP1" "hsa:26015; Q9BWH6; Q9H9I2; Q9NSQ5; Q9P2E4; Q9UFS7" "" "" "0" "0" "1.077" "0.955" "1.138" "1.085" "0.912" "1.099" "1.103" "1.009" "1.251" "431.9" "465.4" "412.3" "491.3" "468.6" "393.7" "474.7" "476.5" "435.9" "540.3" "" "" "" "" "" "" "" "" "" "" "389.9" "359.0" "318.9" "330.8" "390.9" "336.0" "402.7" "344.9" "294.0" "540.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5615919369887998349" "False" "High" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "0.000" "False" "30.659" "12" "3" "9" "3" "392" "42.9" "5.97" "20.16" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "0" "1.049" "1.038" "1.019" "1.038" "1.116" "0.979" "1.056" "1.060" "0.683" "241.2" "252.9" "250.3" "245.9" "250.4" "269.1" "236.0" "254.7" "255.7" "164.6" "" "" "" "" "" "" "" "" "" "" "217.7" "195.1" "193.6" "165.6" "208.9" "229.7" "200.2" "184.3" "172.5" "164.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205660111365886564" "False" "High" "IsMasterProtein" "Q92599" "Septin-8 OS=Homo sapiens OX=9606 GN=SEPTIN8 PE=1 SV=4" "0.000" "False" "30.635" "13" "7" "14" "4" "483" "55.7" "6.28" "29.76" "7" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23176" "ENSG00000164402" "SEPTIN8" "A6NC65; A6NKP6; F6W7K9; hsa:23176; Q8IX36; Q8IX37; Q92599; Q9BVB3" "" "22q11.2 copy number variation syndrome" "1" "0" "1.049" "1.202" "1.106" "1.012" "1.112" "1.081" "1.079" "1.011" "0.872" "204.2" "214.1" "245.4" "225.8" "206.7" "227.0" "220.7" "220.3" "206.5" "178.1" "" "" "" "" "" "" "" "" "" "" "184.3" "165.2" "189.8" "152.1" "172.4" "193.7" "187.2" "159.4" "139.3" "178.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667619497174905717" "False" "High" "IsMasterProtein" "Q96MW1" "Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2" "0.000" "False" "30.629" "30" "5" "6" "5" "224" "25.2" "4.92" "20.57" "5" "" "cytosol" "" "" "124808" "ENSG00000180329" "CCDC43" "C9JVK9; hsa:124808; Q96MW1" "" "" "0" "0" "1.012" "0.944" "0.893" "0.941" "0.902" "1.023" "1.030" "0.837" "0.693" "467.5" "473.3" "441.4" "417.5" "440.0" "421.5" "478.3" "481.6" "391.3" "323.8" "" "" "" "" "" "" "" "" "" "" "422.0" "365.1" "341.4" "281.1" "367.0" "359.7" "405.8" "348.6" "263.9" "323.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375122853346024923" "False" "High" "IsMasterProtein" "Q9C0E2" "Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2" "0.000" "False" "30.549" "6" "7" "9" "7" "1151" "130.1" "5.05" "26.57" "7" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08767" "64328" "ENSG00000132953" "XPO4" "hsa:64328; Q5VUZ5; Q8N3V6; Q9C0E2; Q9H934" "" "eIF5A regulation in response to inhibition of the nuclear export system" "1" "0" "1.065" "0.899" "1.137" "0.985" "0.970" "0.979" "0.959" "1.128" "0.799" "133.9" "142.6" "120.4" "152.2" "131.9" "129.8" "131.1" "128.3" "151.1" "107.0" "" "" "" "" "" "" "" "" "" "" "120.8" "110.0" "93.1" "102.5" "110.0" "110.8" "111.2" "92.9" "101.9" "107.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8976168612742678464" "False" "High" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "0.000" "False" "30.443" "17" "4" "8" "3" "272" "31.2" "11.59" "25.51" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "1.032" "0.851" "0.955" "1.063" "0.884" "1.029" "0.883" "0.807" "0.845" "392.8" "405.5" "334.4" "375.0" "417.7" "347.2" "404.1" "346.9" "316.8" "332.0" "" "" "" "" "" "" "" "" "" "" "354.6" "312.7" "258.7" "252.5" "348.4" "296.3" "342.8" "251.0" "213.7" "332.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2665594491149638353" "False" "High" "IsMasterProtein" "P12931" "Proto-oncogene tyrosine-protein kinase Src OS=Homo sapiens OX=9606 GN=SRC PE=1 SV=3" "0.000" "False" "30.429" "13" "7" "9" "6" "536" "59.8" "7.42" "27.96" "7" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "6714" "ENSG00000197122; ENSG00000291971" "SRC" "E1P5V4; hsa:6714; P12931; Q76P87; Q86VB9; Q9H5A8" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; G alpha (i) signalling events; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; Signaling by BRAF and RAF1 fusions; Regulation of RUNX3 expression and activity; RHOU GTPase cycle; DCC mediated attractive signaling; Downstream signal transduction; Signaling by ERBB2; Nuclear signaling by ERBB4; RAF activation; GAB1 signalosome; MET activates PTK2 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; RUNX2 regulates osteoblast differentiation; Long-term potentiation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of commissural axon pathfinding by SLIT and ROBO; Netrin mediated repulsion signals; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Activated NTRK2 signals through FYN; Downregulation of ERBB4 signaling; Regulation of RUNX1 Expression and Activity; Activated NTRK3 signals through PI3K" "Androgen receptor signaling pathway; Angiogenesis; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Aryl hydrocarbon receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Robo4 and VEGF signaling pathways crosstalk; Fibrin complement receptor 3 signaling pathway; MET in type 1 papillary renal cell carcinoma; Acute viral myocarditis; NRF2-ARE regulation; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway" "90" "1" "1.134" "0.924" "0.927" "1.133" "0.974" "0.999" "1.058" "1.000" "0.870" "338.5" "384.0" "312.8" "313.6" "383.5" "329.6" "338.1" "358.2" "338.5" "294.6" "" "" "" "" "" "" "" "" "" "" "305.6" "296.2" "242.0" "211.2" "319.9" "281.3" "286.8" "259.2" "228.3" "294.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4729149100999833326" "False" "High" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "0.000" "False" "30.411" "17" "5" "9" "5" "314" "35.8" "4.74" "30.14" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Macroautophagy" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "6" "0" "0.905" "0.782" "0.901" "0.875" "0.810" "0.943" "0.894" "0.782" "0.672" "608.5" "550.7" "475.6" "548.3" "532.5" "492.7" "574.1" "544.2" "476.1" "409.1" "" "" "" "" "" "" "" "" "" "" "549.3" "424.8" "367.9" "369.2" "444.2" "420.5" "487.0" "393.8" "321.1" "409.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647128743561798150" "False" "High" "IsMasterProtein" "P78417" "Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2" "0.000" "False" "30.391" "26" "6" "9" "6" "241" "27.5" "6.60" "27.79" "6" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13409, Pf14497" "9446" "ENSG00000148834" "GSTO1" "D3DRA3; F5H7H0; hsa:9446; P78417; Q5TA03; Q7Z3T2" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Vitamin C (ascorbate) metabolism; Methylation" "Myometrial relaxation and contraction pathways; Arsenic metabolism and reactive oxygen species generation; Metapathway biotransformation Phase I and II" "7" "0" "0.965" "1.052" "0.961" "1.017" "1.093" "0.958" "1.004" "1.013" "0.771" "941.2" "907.9" "990.6" "904.2" "957.7" "1029.2" "902.1" "945.2" "953.7" "725.7" "" "" "" "" "" "" "" "" "" "" "849.6" "700.3" "766.2" "608.9" "798.8" "878.4" "765.2" "684.0" "643.3" "725.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1760362922626917016" "False" "High" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "0.000" "False" "30.374" "21" "3" "8" "3" "172" "18.6" "9.51" "23.87" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "1.161" "0.989" "0.947" "1.123" "1.138" "0.994" "1.017" "1.112" "0.883" "451.1" "523.7" "446.0" "427.3" "506.5" "513.2" "448.4" "458.8" "501.8" "398.3" "" "" "" "" "" "" "" "" "" "" "407.2" "404.0" "345.0" "287.7" "422.5" "438.0" "380.4" "332.0" "338.4" "398.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7707069974883679945" "False" "High" "IsMasterProtein" "P11836" "B-lymphocyte antigen CD20 OS=Homo sapiens OX=9606 GN=MS4A1 PE=1 SV=1" "0.000" "False" "30.336" "13" "4" "8" "4" "297" "33.1" "5.05" "26.91" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04103" "931" "ENSG00000156738" "MS4A1" "A6NMS4; B4DT24; hsa:931; P08984; P11836; Q13963" "" "Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "2" "0" "1.149" "0.995" "1.044" "0.954" "0.783" "1.089" "1.142" "0.872" "0.545" "1058.7" "1216.8" "1053.7" "1104.9" "1009.7" "828.5" "1153.0" "1208.9" "923.5" "577.5" "" "" "" "" "" "" "" "" "" "" "955.6" "938.6" "815.0" "744.0" "842.2" "707.1" "978.0" "874.8" "622.9" "577.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4424001123554839232" "False" "High" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "0.000" "False" "30.334" "19" "9" "12" "9" "435" "49.6" "9.54" "35.04" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "Potential therapeutics for SARS; MHC class II antigen presentation; EPH-ephrin mediated repulsion of cells; Cargo recognition for clathrin-mediated endocytosis; VLDLR internalisation and degradation; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "21" "0" "1.039" "1.184" "0.987" "1.018" "1.170" "1.059" "1.111" "1.151" "0.981" "536.8" "557.9" "635.5" "529.7" "546.6" "627.9" "568.6" "596.6" "617.6" "526.8" "" "" "" "" "" "" "" "" "" "" "484.6" "430.3" "491.5" "356.7" "456.0" "535.9" "482.3" "431.8" "416.6" "526.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634155616669097337" "False" "High" "IsMasterProtein" "P42768" "Actin nucleation-promoting factor WAS OS=Homo sapiens OX=9606 GN=WAS PE=1 SV=4" "0.000" "False" "30.311" "14" "6" "9" "6" "502" "52.9" "6.64" "29.31" "6" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00568, Pf00786, Pf02205" "7454" "ENSG00000015285" "WAS" "hsa:7454; P42768; Q9BU11; Q9UNJ9" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Generation of second messenger molecules; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle" "Pathogenic Escherichia coli infection; Complement system; Chemokine signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor signaling pathway" "13" "0" "1.032" "1.205" "1.081" "1.011" "1.167" "1.023" "0.956" "1.232" "1.246" "390.2" "402.6" "470.2" "421.8" "394.4" "455.5" "399.1" "373.2" "480.9" "486.1" "" "" "" "" "" "" "" "" "" "" "352.2" "310.6" "363.7" "284.0" "329.0" "388.8" "338.6" "270.1" "324.4" "486.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8328010223539768625" "False" "High" "IsMasterProtein" "P0DMU7" "Cancer/testis antigen family 45 member A6 OS=Homo sapiens OX=9606 GN=CT45A6 PE=2 SV=1" "0.000" "False" "30.275" "29" "6" "13" "2" "189" "21.2" "9.69" "39.97" "6" "" "" "" "Pf15300" "101060211; 441521; 541465" "ENSG00000278289" "CT45A6" "hsa:101060211; hsa:441521; hsa:541465; P0DMU7; Q8N7B7" "" "" "0" "3" "0.941" "0.965" "0.903" "0.897" "0.882" "0.936" "0.967" "0.795" "0.664" "803.3" "755.9" "775.3" "725.2" "720.5" "708.2" "751.7" "777.1" "638.4" "533.1" "" "" "" "" "" "" "" "" "" "" "725.1" "583.1" "599.7" "488.3" "601.0" "604.5" "637.7" "562.4" "430.6" "533.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5775237487534858758" "False" "High" "IsMasterProtein" "P62750" "Large ribosomal subunit protein uL23 OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "0.000" "False" "30.250" "30" "5" "15" "5" "156" "17.7" "10.45" "47.45" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.871" "1.096" "0.932" "0.934" "0.936" "0.994" "0.998" "0.993" "0.319" "1352.2" "1177.2" "1482.1" "1260.8" "1262.3" "1265.9" "1344.7" "1349.7" "1342.7" "431.1" "" "" "" "" "" "" "" "" "" "" "1220.6" "908.0" "1146.3" "849.0" "1053.0" "1080.5" "1140.7" "976.8" "905.6" "431.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812741614734953835" "False" "High" "IsMasterProtein" "Q7L9L4" "MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3" "0.000" "False" "30.180" "22" "4" "7" "4" "216" "25.1" "6.73" "21.60" "4" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "92597" "ENSG00000173542" "MOB1B" "B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23" "Signaling by Hippo" "Pleural mesothelioma" "2" "0" "0.839" "0.975" "0.932" "1.011" "0.967" "1.010" "0.983" "1.011" "0.767" "407.2" "341.8" "396.8" "379.4" "411.7" "393.7" "411.1" "400.4" "411.5" "312.3" "" "" "" "" "" "" "" "" "" "" "367.5" "263.7" "306.9" "255.5" "343.4" "336.0" "348.7" "289.8" "277.5" "312.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1721823371863977969" "False" "High" "IsMasterProtein" "Q92973" "Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2" "0.000" "False" "30.136" "8" "6" "10" "5" "898" "102.3" "4.98" "34.37" "6" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "3842" "ENSG00000083312" "TNPO1" "B4DVC6; hsa:3842; Q92957; Q92973; Q92975" "Postmitotic nuclear pore complex (NPC) reformation; Intraflagellar transport; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" "22q11.2 copy number variation syndrome" "4" "0" "0.905" "0.783" "0.955" "0.932" "0.764" "1.015" "0.827" "0.762" "2.695" "457.2" "413.8" "357.9" "436.8" "425.9" "349.2" "464.1" "378.3" "348.4" "1232.3" "" "" "" "" "" "" "" "" "" "" "412.7" "319.2" "276.8" "294.1" "355.3" "298.0" "393.7" "273.8" "235.0" "1232.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839612719642205858" "False" "High" "IsMasterProtein" "P09417" "Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2" "0.000" "False" "30.096" "22" "4" "7" "4" "244" "25.8" "7.37" "30.05" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00106" "5860" "ENSG00000151552" "QDPR" "A8K158; B3KW71; hsa:5860; P09417; Q53F52; Q9H3M5" "Phenylalanine metabolism" "" "1" "0" "0.947" "0.897" "0.983" "0.992" "0.946" "1.008" "1.073" "0.992" "0.738" "464.1" "439.4" "416.4" "456.4" "460.3" "439.0" "467.7" "497.9" "460.3" "342.7" "" "" "" "" "" "" "" "" "" "" "418.9" "339.0" "322.0" "307.3" "384.0" "374.7" "396.7" "360.4" "310.5" "342.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "291264612704325176" "False" "High" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "0.000" "False" "30.082" "17" "7" "8" "7" "434" "46.7" "4.42" "27.65" "7" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF" "Nucleotide-binding oligomerization domain (NOD) pathway" "5" "0" "1.011" "1.009" "1.023" "1.094" "1.060" "1.004" "1.091" "1.099" "1.155" "489.1" "494.3" "493.4" "500.4" "534.9" "518.3" "491.0" "533.7" "537.4" "565.1" "" "" "" "" "" "" "" "" "" "" "441.5" "381.3" "381.6" "337.0" "446.2" "442.4" "416.5" "386.3" "362.4" "565.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5669236386910036788" "False" "High" "IsMasterProtein" "P46783" "Small ribosomal subunit protein eS10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "0.000" "False" "30.052" "42" "7" "17" "6" "165" "18.9" "10.15" "54.88" "7" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.930" "0.996" "0.919" "1.087" "0.980" "0.937" "1.045" "0.984" "0.663" "898.5" "835.5" "894.6" "825.7" "976.3" "880.4" "842.0" "939.0" "883.7" "595.9" "" "" "" "" "" "" "" "" "" "" "811.1" "644.4" "691.9" "556.0" "814.4" "751.5" "714.2" "679.6" "596.1" "595.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700726988884900620" "False" "High" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "0.000" "False" "30.051" "25" "4" "13" "4" "176" "18.4" "9.44" "42.33" "4" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "1.009" "1.051" "1.072" "0.881" "0.948" "1.001" "1.103" "0.960" "0.644" "722.8" "728.9" "759.6" "775.0" "637.1" "685.5" "723.2" "797.2" "693.8" "465.7" "" "" "" "" "" "" "" "" "" "" "652.4" "562.3" "587.5" "521.9" "531.4" "585.1" "613.5" "576.9" "468.0" "465.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251900378438964283" "False" "High" "IsMasterProtein" "Q13188" "Serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=STK3 PE=1 SV=2" "0.000" "False" "29.891" "14" "6" "10" "2" "491" "56.3" "5.24" "28.14" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6788" "ENSG00000104375" "STK3" "A8K722; B3KYA7; hsa:6788; Q13188; Q15445; Q15801; Q96FM6" "Signaling by Hippo" "MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "9" "0" "1.160" "1.020" "1.244" "1.110" "0.917" "1.083" "1.272" "1.027" "0.779" "219.3" "254.4" "223.8" "272.9" "243.5" "201.0" "237.5" "278.8" "225.2" "170.9" "" "" "" "" "" "" "" "" "" "" "198.0" "196.2" "173.1" "183.7" "203.1" "171.6" "201.5" "201.8" "151.9" "170.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4660808662127601060" "False" "High" "IsMasterProtein" "Q9NR09" "Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=3" "0.000" "False" "29.870" "2" "11" "11" "11" "4857" "529.9" "6.05" "29.36" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00179, Pf00653, Pf12356" "57448" "ENSG00000115760" "BIRC6" "hsa:57448; Q9NR09; Q9ULD1" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "" "2" "0" "0.935" "0.905" "1.003" "1.012" "0.903" "0.992" "1.080" "0.879" "1.128" "239.8" "224.3" "217.1" "240.6" "242.8" "216.6" "238.0" "258.9" "210.8" "270.4" "" "" "" "" "" "" "" "" "" "" "216.4" "173.0" "167.9" "162.0" "202.5" "184.8" "201.9" "187.3" "142.2" "270.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6289921617317730415" "False" "High" "IsMasterProtein" "Q9BWF3" "RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1" "0.000" "False" "29.811" "21" "8" "11" "8" "364" "40.3" "7.08" "34.25" "8" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00098" "5936" "ENSG00000173933" "RBM4" "B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3" "Circadian Clock" "" "1" "0" "0.935" "0.895" "0.871" "0.990" "0.939" "0.941" "0.832" "0.943" "3.101" "334.2" "312.5" "299.0" "291.0" "330.7" "313.6" "314.5" "277.9" "315.2" "1036.1" "" "" "" "" "" "" "" "" "" "" "301.6" "241.0" "231.2" "196.0" "275.9" "267.7" "266.8" "201.1" "212.6" "1036.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928558694847449526" "False" "High" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "0.000" "False" "29.803" "21" "4" "12" "4" "218" "25.0" "4.93" "33.96" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "" "6" "0" "0.992" "0.994" "0.966" "1.040" "0.908" "1.033" "0.966" "0.923" "1.014" "580.9" "576.1" "577.5" "561.1" "604.4" "527.2" "599.9" "561.0" "536.5" "589.2" "" "" "" "" "" "" "" "" "" "" "524.4" "444.4" "446.7" "377.8" "504.2" "450.0" "508.9" "406.0" "361.8" "589.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5375173174660804131" "False" "High" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "0.000" "False" "29.772" "16" "5" "7" "5" "335" "36.0" "9.28" "24.60" "5" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Omega-6-fatty acids in senescence" "5" "0" "0.963" "1.101" "1.090" "1.035" "1.052" "1.049" "1.133" "1.101" "0.637" "615.8" "593.2" "677.8" "671.0" "637.2" "648.1" "646.0" "697.6" "678.0" "392.1" "" "" "" "" "" "" "" "" "" "" "555.9" "457.6" "524.2" "451.8" "531.5" "553.1" "548.0" "504.8" "457.3" "392.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1723896581553543701" "False" "High" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "0.000" "False" "29.769" "12" "5" "11" "5" "443" "48.2" "8.66" "35.64" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "PTK6 Regulates Proteins Involved in RNA Processing" "Leptin signaling pathway; Primary ovarian insufficiency" "3" "0" "1.044" "1.123" "0.926" "0.923" "1.020" "0.908" "1.011" "1.060" "0.882" "1170.2" "1221.8" "1314.3" "1083.5" "1080.3" "1193.6" "1062.2" "1183.0" "1240.0" "1032.0" "" "" "" "" "" "" "" "" "" "" "1056.3" "942.4" "1016.5" "729.6" "901.1" "1018.8" "901.0" "856.1" "836.4" "1032.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7222850354556005820" "False" "High" "IsMasterProtein" "P20839" "Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2" "0.000" "False" "29.736" "11" "6" "10" "4" "514" "55.4" "6.90" "33.30" "6" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3614" "ENSG00000106348" "IMPDH1" "A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; hsa:3614; J3KNX8; P20839; Q8N194; Q96NU2" "Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "" "4" "0" "1.034" "0.723" "1.112" "1.009" "0.711" "1.057" "1.021" "0.738" "0.481" "343.9" "355.5" "248.8" "382.3" "347.0" "244.6" "363.6" "351.1" "254.0" "165.3" "" "" "" "" "" "" "" "" "" "" "310.4" "274.2" "192.4" "257.4" "289.4" "208.8" "308.4" "254.1" "171.3" "165.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3338073365584811594" "False" "High" "IsMasterProtein" "P83731" "Large ribosomal subunit protein eL24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "0.000" "False" "29.724" "30" "5" "11" "5" "157" "17.8" "11.25" "32.87" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.967" "1.172" "1.053" "1.118" "1.029" "1.176" "1.103" "1.094" "0.519" "1206.3" "1166.2" "1413.9" "1270.4" "1349.1" "1241.4" "1419.0" "1331.0" "1319.2" "626.5" "" "" "" "" "" "" "" "" "" "" "1088.9" "899.5" "1093.6" "855.5" "1125.4" "1059.6" "1203.7" "963.3" "889.8" "626.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6083245125138804483" "False" "High" "IsMasterProtein" "Q15027" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ACAP1 PE=1 SV=1" "0.000" "False" "29.667" "9" "5" "5" "5" "740" "81.5" "7.66" "19.34" "5" "transport" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00023, Pf00169, Pf01412, Pf16746" "9744" "ENSG00000072818; ENSG00000288169" "ACAP1" "hsa:9744; Q15027; Q53XN9" "" "Nucleotide-binding oligomerization domain (NOD) pathway" "1" "0" "0.964" "0.926" "0.905" "0.933" "0.864" "0.921" "0.890" "0.830" "2.212" "136.8" "131.9" "126.7" "123.8" "127.5" "118.2" "126.0" "121.7" "113.5" "302.5" "" "" "" "" "" "" "" "" "" "" "123.4" "101.7" "98.0" "83.3" "106.4" "100.9" "106.9" "88.0" "76.6" "302.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2331175161516182807" "False" "High" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "0.000" "False" "29.577" "12" "5" "7" "5" "418" "45.4" "7.99" "25.36" "5" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "1.018" "0.926" "0.976" "1.043" "0.914" "1.074" "0.977" "0.923" "1.078" "710.4" "723.0" "658.0" "693.6" "740.6" "649.3" "762.8" "694.3" "655.7" "765.9" "" "" "" "" "" "" "" "" "" "" "641.2" "557.7" "508.9" "467.0" "617.8" "554.2" "647.1" "502.5" "442.3" "765.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5215276665585730267" "False" "High" "IsMasterProtein" "Q9BTD8" "RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1" "0.000" "False" "29.555" "13" "5" "8" "5" "480" "50.4" "9.63" "22.11" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79171" "ENSG00000126254" "RBM42" "hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66" "mRNA Splicing - Major Pathway" "" "1" "0" "0.918" "1.086" "1.034" "0.873" "1.012" "1.117" "1.068" "0.976" "0.959" "116.2" "106.7" "126.2" "120.1" "101.4" "117.6" "129.8" "124.1" "113.4" "111.4" "" "" "" "" "" "" "" "" "" "" "104.9" "82.3" "97.6" "80.9" "84.6" "100.3" "110.1" "89.8" "76.5" "111.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8117558468974038429" "False" "High" "IsMasterProtein" "Q96Q11" "CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2" "0.000" "False" "29.471" "16" "8" "12" "8" "434" "50.1" "8.10" "33.27" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01743, Pf12627" "51095" "ENSG00000072756" "TRNT1" "A8K2Z6; B7WP13; C9JKA2; hsa:51095; Q8ND57; Q96Q11; Q9BS97; Q9Y362" "tRNA processing in the nucleus; tRNA processing in the mitochondrion" "" "2" "0" "1.071" "1.079" "1.148" "1.089" "1.090" "1.102" "1.113" "1.079" "1.029" "646.8" "692.5" "697.8" "742.6" "704.2" "704.8" "712.5" "719.9" "697.6" "665.5" "" "" "" "" "" "" "" "" "" "" "583.8" "534.2" "539.7" "500.1" "587.4" "601.6" "604.4" "521.0" "470.5" "665.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6115802108714275107" "False" "High" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "0.000" "False" "29.439" "32" "6" "12" "6" "225" "25.0" "5.69" "31.41" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Serine biosynthesis" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "6" "0" "0.970" "0.993" "0.976" "0.991" "1.014" "0.989" "1.021" "1.019" "0.664" "915.5" "888.1" "909.4" "893.2" "907.2" "928.2" "905.7" "934.6" "933.1" "607.6" "" "" "" "" "" "" "" "" "" "" "826.4" "685.1" "703.4" "601.5" "756.8" "792.3" "768.3" "676.4" "629.4" "607.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558081350695480590" "False" "High" "IsMasterProtein" "O43172" "U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2" "0.000" "False" "29.416" "15" "8" "9" "8" "522" "58.4" "7.42" "26.68" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08799" "9128" "ENSG00000136875" "PRPF4" "hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.998" "0.879" "0.976" "0.907" "0.851" "0.950" "0.979" "0.905" "1.715" "436.4" "435.3" "383.6" "425.8" "395.7" "371.4" "414.8" "427.3" "395.2" "748.5" "" "" "" "" "" "" "" "" "" "" "394.0" "335.8" "296.7" "286.7" "330.1" "317.0" "351.9" "309.2" "266.5" "748.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823041984393634953" "False" "High" "IsMasterProtein" "P25774" "Cathepsin S OS=Homo sapiens OX=9606 GN=CTSS PE=1 SV=3" "0.000" "False" "29.415" "22" "6" "7" "6" "331" "37.5" "8.34" "22.51" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1520" "ENSG00000163131" "CTSS" "B4DWC9; D3DV05; hsa:1520; P25774; Q5T5I0; Q6FHS5; Q9BUG3" "MHC class II antigen presentation; Neutrophil degranulation; Degradation of the extracellular matrix; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "" "6" "0" "0.989" "1.086" "0.961" "1.066" "1.111" "0.918" "0.998" "1.079" "0.804" "401.2" "396.6" "435.5" "385.4" "427.7" "445.7" "368.2" "400.5" "432.9" "322.4" "" "" "" "" "" "" "" "" "" "" "362.1" "305.9" "336.8" "259.5" "356.7" "380.4" "312.4" "289.8" "292.0" "322.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-705908850981217680" "False" "High" "IsMasterProtein" "Q9NWZ5" "Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2" "0.000" "False" "29.384" "14" "8" "9" "8" "548" "61.1" "7.36" "26.76" "8" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00485, Pf14681" "54963" "ENSG00000198276" "UCKL1" "B7Z8N2; hsa:54963; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2; Q9NWZ5" "Pyrimidine salvage" "Pyrimidine metabolism" "2" "0" "1.037" "0.823" "1.016" "1.001" "0.785" "0.984" "1.000" "0.890" "1.000" "261.0" "270.6" "214.9" "265.1" "261.2" "205.0" "256.8" "260.9" "232.2" "260.9" "" "" "" "" "" "" "" "" "" "" "235.6" "208.7" "166.2" "178.5" "217.8" "174.9" "217.8" "188.8" "156.6" "260.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1347928425928225454" "False" "High" "IsMasterProtein" "O60925" "Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2" "0.000" "False" "29.384" "35" "5" "12" "5" "122" "14.2" "6.81" "39.98" "5" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "5201" "ENSG00000113068" "PFDN1" "B2RD02; hsa:5201; O60925; Q53F95; Q96EX6" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "1.018" "1.004" "1.066" "0.941" "0.987" "1.000" "1.086" "0.941" "0.670" "742.6" "756.1" "745.4" "791.4" "698.7" "732.8" "742.5" "806.4" "698.4" "497.4" "" "" "" "" "" "" "" "" "" "" "670.3" "583.2" "576.5" "532.9" "582.9" "625.5" "629.8" "583.6" "471.1" "497.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8809739148280005605" "False" "High" "IsMasterProtein" "P46776" "Large ribosomal subunit protein uL15 OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "0.000" "False" "29.371" "29" "4" "8" "4" "148" "16.6" "11.00" "27.83" "4" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "0.876" "1.010" "0.899" "0.975" "0.948" "1.029" "0.995" "0.926" "0.326" "414.7" "363.4" "419.0" "372.7" "404.5" "393.2" "426.8" "412.6" "384.0" "135.2" "" "" "" "" "" "" "" "" "" "" "374.3" "280.3" "324.1" "251.0" "337.4" "335.6" "362.1" "298.6" "259.0" "135.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7212838211136634633" "False" "High" "IsMasterProtein" "Q9NYY8" "FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1" "0.000" "False" "29.336" "9" "5" "7" "5" "710" "81.4" "8.05" "22.13" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "22868" "ENSG00000118246" "FASTKD2" "hsa:22868; Q9NVX6; Q9NYY8; Q9Y2H7" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "" "1" "0" "0.984" "0.886" "0.900" "1.052" "0.948" "0.873" "0.961" "0.949" "1.225" "133.1" "130.9" "117.9" "119.8" "140.1" "126.2" "116.2" "127.9" "126.3" "163.1" "" "" "" "" "" "" "" "" "" "" "120.2" "101.0" "91.2" "80.7" "116.9" "107.7" "98.5" "92.5" "85.2" "163.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4990507016878311040" "False" "High" "IsMasterProtein" "P42126" "Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1" "0.000" "False" "29.329" "18" "5" "11" "5" "302" "32.8" "8.54" "27.58" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1632" "ENSG00000167969" "ECI1" "A8K512; hsa:1632; P42126; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6" "Mitochondrial protein degradation; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "5" "0" "0.802" "0.995" "0.887" "0.866" "1.019" "0.863" "0.817" "0.973" "0.721" "380.3" "305.2" "378.4" "337.5" "329.4" "387.5" "328.4" "310.9" "369.9" "274.4" "" "" "" "" "" "" "" "" "" "" "343.3" "235.4" "292.6" "227.3" "274.8" "330.7" "278.5" "225.0" "249.5" "274.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137976061761612537" "False" "High" "IsMasterProtein" "Q16512" "Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2" "0.000" "False" "29.317" "11" "8" "8" "8" "942" "103.9" "6.37" "23.92" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5585" "ENSG00000123143" "PKN1" "A8K7W5; B2R9R4; B3KVN3; hsa:5585; Q15143; Q16512; Q504U4; Q8IUV5; Q9UD44" "RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; RHOC GTPase cycle" "Apoptosis-related network due to altered Notch3 in ovarian cancer; PI3K-Akt signaling pathway; IL-18 signaling pathway; G13 signaling pathway" "10" "0" "0.969" "0.833" "0.916" "0.966" "0.935" "0.947" "0.905" "0.680" "1.548" "145.9" "141.4" "121.6" "133.6" "140.9" "136.5" "138.2" "132.1" "99.3" "225.8" "" "" "" "" "" "" "" "" "" "" "131.7" "109.1" "94.0" "90.0" "117.6" "116.5" "117.3" "95.6" "67.0" "225.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2986049448252169894" "False" "High" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "0.000" "False" "29.315" "5" "7" "10" "6" "1231" "141.2" "5.43" "31.64" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "9" "0" "0.964" "0.775" "0.964" "0.993" "0.762" "0.891" "0.938" "0.827" "0.663" "662.4" "638.5" "513.1" "638.5" "658.1" "504.8" "590.1" "621.4" "547.8" "439.0" "" "" "" "" "" "" "" "" "" "" "598.0" "492.5" "396.8" "430.0" "548.9" "430.8" "500.5" "449.7" "369.5" "439.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174641781052764353" "False" "High" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "0.000" "False" "29.306" "19" "7" "9" "7" "348" "37.9" "7.23" "24.99" "7" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "Purine salvage" "" "1" "0" "0.996" "1.012" "0.945" "1.062" "1.118" "0.977" "1.020" "1.097" "0.686" "408.7" "407.2" "413.6" "386.3" "433.9" "457.1" "399.2" "416.9" "448.4" "280.4" "" "" "" "" "" "" "" "" "" "" "368.9" "314.1" "319.9" "260.1" "362.0" "390.1" "338.6" "301.7" "302.5" "280.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980948205033410350" "False" "High" "IsMasterProtein" "Q8WXI9" "Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1" "0.000" "False" "29.306" "12" "6" "7" "5" "593" "65.2" "9.70" "20.93" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "57459" "ENSG00000143614; ENSG00000261992" "GATAD2B" "D3DUZ2; hsa:57459; Q5VUR2; Q7LG68; Q8WXI9; Q9ULS0" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "" "6" "1" "1.034" "1.339" "1.044" "1.121" "1.314" "1.061" "0.955" "1.387" "3.202" "228.8" "236.5" "306.2" "238.9" "256.5" "300.5" "242.8" "218.5" "317.4" "732.4" "" "" "" "" "" "" "" "" "" "" "206.5" "182.5" "236.8" "160.9" "214.0" "256.5" "205.9" "158.1" "214.1" "732.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-566189082840404496" "False" "High" "IsMasterProtein" "Q8WVM7" "Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3" "0.000" "False" "29.296" "3" "5" "5" "4" "1258" "144.3" "5.59" "18.35" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10274" "ENSG00000118007" "STAG1" "hsa:10274; O00539; Q6P275; Q8WVM7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "10" "0" "0.952" "0.821" "1.090" "0.972" "0.779" "0.894" "0.899" "0.854" "0.725" "96.7" "92.0" "79.4" "105.4" "94.0" "75.3" "86.5" "87.0" "82.5" "70.1" "" "" "" "" "" "" "" "" "" "" "87.3" "71.0" "61.4" "71.0" "78.4" "64.3" "73.4" "62.9" "55.7" "70.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008482199911470815" "False" "High" "IsMasterProtein" "O43516" "WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3" "0.000" "False" "29.292" "16" "7" "8" "7" "503" "51.2" "11.47" "25.47" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "7456" "ENSG00000115935" "WIPF1" "B8ZZM1; D3DPE4; hsa:7456; O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs" "" "5" "0" "0.935" "0.842" "1.108" "0.935" "0.905" "1.009" "1.030" "0.798" "0.598" "215.4" "201.4" "181.4" "238.7" "201.4" "195.0" "217.4" "221.8" "172.0" "128.8" "" "" "" "" "" "" "" "" "" "" "194.4" "155.4" "140.3" "160.7" "168.0" "166.5" "184.4" "160.5" "116.0" "128.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272350597619465793" "False" "High" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "0.000" "False" "29.281" "23" "6" "10" "6" "305" "35.1" "5.69" "29.12" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "0.933" "0.861" "0.923" "0.924" "0.865" "0.933" "0.948" "0.967" "0.781" "556.2" "518.7" "478.6" "513.5" "514.1" "481.2" "519.0" "527.5" "538.0" "434.5" "" "" "" "" "" "" "" "" "" "" "502.1" "400.1" "370.2" "345.8" "428.8" "410.7" "440.3" "381.7" "362.9" "434.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6056381579766233841" "False" "High" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "0.000" "False" "29.262" "18" "8" "11" "7" "406" "46.6" "6.16" "27.05" "8" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "0" "0.910" "0.903" "1.025" "0.908" "0.876" "0.946" "0.928" "0.849" "1.276" "403.9" "367.6" "364.9" "414.0" "366.9" "354.0" "382.3" "374.7" "343.0" "515.5" "" "" "" "" "" "" "" "" "" "" "364.6" "283.6" "282.2" "278.8" "306.1" "302.1" "324.3" "271.1" "231.4" "515.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-729542664091126034" "False" "High" "IsMasterProtein" "Q93008" "Ubiquitin carboxyl-terminal hydrolase 9X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4" "0.000" "False" "29.256" "4" "9" "10" "9" "2554" "290.3" "5.80" "30.42" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8239" "ENSG00000124486" "USP9X" "hsa:8239; O75550; Q8WWT3; Q8WX12; Q93008" "Ub-specific processing proteases; Amyloid fiber formation; RHOV GTPase cycle; RHOU GTPase cycle; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Peroxisomal protein import; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "Ciliopathies; Bardet-Biedl syndrome" "9" "0" "0.903" "0.852" "1.030" "1.004" "0.794" "0.916" "0.995" "0.829" "1.448" "238.0" "214.8" "202.7" "245.1" "238.9" "188.9" "218.1" "236.8" "197.4" "344.5" "" "" "" "" "" "" "" "" "" "" "214.8" "165.7" "156.8" "165.0" "199.3" "161.3" "185.0" "171.4" "133.1" "344.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029493779746441827" "False" "High" "IsMasterProtein" "Q7L1Q6" "eIF5-mimic protein 2 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "0.000" "False" "29.245" "18" "9" "10" "8" "419" "48.0" "5.92" "31.30" "9" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "0.732" "0.760" "0.776" "0.839" "0.596" "0.707" "0.671" "0.724" "3.943" "85.0" "62.3" "64.6" "65.9" "71.3" "50.7" "60.1" "57.0" "61.5" "335.1" "" "" "" "" "" "" "" "" "" "" "76.7" "48.0" "50.0" "44.4" "59.5" "43.3" "51.0" "41.2" "41.5" "335.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "647250025127974157" "False" "High" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "0.000" "False" "29.212" "35" "3" "7" "3" "111" "12.0" "9.83" "24.41" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "Termination of translesion DNA synthesis" "" "1" "0" "0.978" "0.844" "0.855" "0.955" "0.825" "0.972" "1.084" "0.832" "0.679" "249.7" "244.1" "210.6" "213.5" "238.4" "205.9" "242.6" "270.6" "207.8" "169.4" "" "" "" "" "" "" "" "" "" "" "225.4" "188.3" "162.9" "143.8" "198.9" "175.8" "205.8" "195.8" "140.1" "169.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838480320139969571" "False" "High" "IsMasterProtein" "Q13951" "Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2" "0.000" "False" "29.165" "24" "4" "7" "4" "182" "21.5" "6.60" "20.92" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02312" "865" "ENSG00000067955" "CBFB" "A8K347; hsa:865; Q13124; Q13951; Q9HCT2" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; RUNX2 regulates osteoblast differentiation; Transcriptional regulation of granulopoiesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Estrogen-dependent gene expression; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; RUNX2 regulates genes involved in cell migration; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX2 regulates chondrocyte maturation; RUNX3 Regulates Immune Response and Cell Migration; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX3 regulates RUNX1-mediated transcription" "Dual hijack model of Vif in HIV infection; Hijack of ubiquitination by SARS-CoV-2" "27" "0" "0.994" "0.808" "0.975" "1.020" "0.840" "0.975" "0.908" "0.778" "1.976" "311.1" "309.4" "251.4" "303.5" "317.5" "261.3" "303.4" "282.5" "242.1" "614.7" "" "" "" "" "" "" "" "" "" "" "280.9" "238.6" "194.4" "204.4" "264.8" "223.0" "257.4" "204.4" "163.3" "614.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "272489793728892869" "False" "High" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "0.000" "False" "29.147" "27" "7" "24" "7" "234" "26.1" "7.78" "60.81" "7" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "1.004" "1.073" "1.024" "1.016" "1.034" "0.928" "1.011" "1.070" "0.711" "1601.7" "1607.4" "1718.7" "1639.8" "1627.9" "1656.9" "1485.8" "1618.8" "1713.7" "1138.0" "" "" "" "" "" "" "" "" "" "" "1445.8" "1239.9" "1329.3" "1104.2" "1358.0" "1414.2" "1260.3" "1171.5" "1155.9" "1138.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636367879172640363" "False" "High" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "0.000" "False" "29.116" "36" "4" "6" "4" "158" "18.0" "6.74" "23.48" "4" "" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.059" "0.835" "1.197" "0.984" "0.815" "0.988" "0.914" "0.861" "2.724" "245.6" "260.1" "205.1" "293.9" "241.7" "200.2" "242.6" "224.5" "211.4" "668.9" "" "" "" "" "" "" "" "" "" "" "221.7" "200.6" "158.6" "197.9" "201.6" "170.9" "205.8" "162.5" "142.6" "668.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683899515612259900" "False" "High" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "0.000" "False" "29.115" "12" "9" "13" "9" "668" "75.0" "9.66" "42.12" "9" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in progeria" "7" "0" "1.020" "1.350" "1.082" "1.068" "1.446" "1.040" "0.953" "1.348" "2.456" "957.9" "977.3" "1293.4" "1036.9" "1022.6" "1385.3" "996.1" "913.1" "1291.5" "2352.5" "" "" "" "" "" "" "" "" "" "" "864.6" "753.8" "1000.3" "698.2" "853.0" "1182.4" "845.0" "660.8" "871.1" "2352.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3546401136209877532" "False" "High" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "0.000" "False" "29.060" "16" "5" "10" "5" "320" "35.6" "6.13" "34.15" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.973" "1.125" "0.985" "1.043" "1.087" "0.910" "0.983" "1.193" "1.612" "496.2" "483.0" "558.3" "489.0" "517.6" "539.4" "451.4" "487.6" "591.8" "799.8" "" "" "" "" "" "" "" "" "" "" "447.9" "372.6" "431.8" "329.3" "431.8" "460.4" "382.9" "352.9" "399.1" "799.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5439043522832827691" "False" "High" "IsMasterProtein" "Q8WZA0" "Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1" "0.000" "False" "29.021" "32" "6" "6" "6" "190" "21.5" "4.94" "21.43" "6" "other biological processes" "" "other molecular function" "Pf06384" "84328" "ENSG00000162441" "LZIC" "B2R6F0; B4E2N0; hsa:84328; Q8WZA0; Q96IU1" "" "" "0" "0" "0.956" "0.880" "0.968" "0.820" "0.869" "0.870" "0.938" "0.821" "0.600" "444.2" "424.6" "391.0" "430.0" "364.4" "386.1" "386.3" "416.6" "364.6" "266.6" "" "" "" "" "" "" "" "" "" "" "400.9" "327.5" "302.4" "289.6" "304.0" "329.5" "327.7" "301.5" "245.9" "266.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6835034816184829460" "False" "High" "IsMasterProtein" "Q13363" "C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2" "0.000" "False" "28.971" "15" "6" "10" "6" "440" "47.5" "6.77" "31.32" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1487" "ENSG00000159692" "CTBP1" "Q13363; Q4W5N3; Q7Z2Q5" "SUMOylation of transcription cofactors; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes; Signaling by TCF7L2 mutants" "Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "14" "0" "1.027" "0.810" "1.073" "1.011" "0.819" "0.935" "0.989" "0.773" "0.745" "265.4" "272.5" "214.9" "284.8" "268.3" "217.4" "248.1" "262.5" "205.2" "197.7" "" "" "" "" "" "" "" "" "" "" "239.6" "210.2" "166.2" "191.8" "223.8" "185.5" "210.5" "190.0" "138.4" "197.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428754804967895147" "False" "High" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "0.000" "False" "28.907" "40" "6" "9" "5" "172" "19.5" "6.34" "29.09" "6" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "Synthesis of pyrophosphates in the cytosol" "" "1" "1" "1.041" "1.001" "0.987" "1.031" "1.244" "1.169" "1.124" "1.162" "1.175" "186.7" "194.3" "186.8" "184.3" "192.4" "232.3" "218.2" "209.9" "216.9" "219.2" "" "" "" "" "" "" "" "" "" "" "168.5" "149.8" "144.5" "124.1" "160.5" "198.2" "185.1" "151.9" "146.3" "219.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1789067979643489698" "False" "High" "IsMasterProtein" "P46976" "Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4" "0.000" "False" "28.818" "19" "6" "15" "6" "350" "39.4" "5.53" "36.12" "6" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01501" "2992" "ENSG00000163754" "GYG1" "D3DNH0; D3DNH1; D3DNH2; hsa:2992; P46976; Q6FHZ1; Q9UNV0" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Myoclonic epilepsy of Lafora; Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism" "10" "0" "1.189" "1.213" "1.049" "1.051" "1.311" "1.104" "1.208" "1.184" "0.806" "168.6" "200.5" "204.5" "176.8" "177.1" "221.0" "186.1" "203.6" "199.6" "135.9" "" "" "" "" "" "" "" "" "" "" "152.2" "154.7" "158.1" "119.1" "147.8" "188.7" "157.9" "147.3" "134.6" "135.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6062683060595135562" "False" "High" "IsMasterProtein" "Q9NVE7" "4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1" "0.000" "False" "28.783" "9" "7" "9" "7" "773" "85.9" "6.28" "25.40" "7" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01937, Pf03630" "55229" "ENSG00000157881; ENSG00000273494" "PANK4" "B9DI84; hsa:55229; Q53EU3; Q5TA84; Q7RTX3; Q9H3X5; Q9NVE7" "Vitamin B5 (pantothenate) metabolism" "1p36 copy number variation syndrome" "2" "0" "1.098" "0.802" "0.959" "1.067" "0.854" "0.980" "1.040" "1.016" "0.934" "169.0" "185.6" "135.6" "162.0" "180.4" "144.3" "165.7" "175.8" "171.7" "157.8" "" "" "" "" "" "" "" "" "" "" "152.6" "143.2" "104.9" "109.1" "150.5" "123.2" "140.6" "127.2" "115.8" "157.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8044840362148842225" "False" "High" "IsMasterProtein" "O95376" "E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1" "0.000" "False" "28.782" "9" "4" "5" "4" "493" "57.8" "5.63" "19.08" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01485, Pf19422" "10425" "ENSG00000177479" "ARIH2" "hsa:10425; O95376; Q9HBZ6; Q9UEM9" "Antigen processing: Ubiquitination & Proteasome degradation" "Modulators of TCR signaling and T cell activation" "2" "0" "0.865" "0.905" "0.994" "1.004" "0.899" "0.984" "0.892" "0.907" "0.768" "217.7" "188.4" "197.0" "216.3" "218.7" "195.7" "214.1" "194.2" "197.4" "167.3" "" "" "" "" "" "" "" "" "" "" "196.5" "145.3" "152.4" "145.7" "182.4" "167.0" "181.7" "140.5" "133.1" "167.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5053375512568543969" "False" "High" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "0.000" "False" "28.757" "13" "7" "9" "7" "509" "54.8" "5.59" "26.87" "7" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Regulation of HSF1-mediated heat shock response" "Parkin-ubiquitin proteasomal system pathway" "2" "0" "1.078" "1.090" "1.056" "1.105" "0.991" "1.068" "0.864" "1.062" "4.214" "336.1" "362.4" "366.3" "354.9" "371.3" "333.0" "359.2" "290.3" "357.1" "1416.4" "" "" "" "" "" "" "" "" "" "" "303.4" "279.6" "283.3" "239.0" "309.7" "284.3" "304.7" "210.1" "240.9" "1416.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4976528031312254709" "False" "High" "IsMasterProtein" "Q92506" "(3R)-3-hydroxyacyl-CoA dehydrogenase OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "0.000" "False" "28.715" "19" "4" "5" "4" "261" "27.0" "6.54" "19.51" "4" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "Fatty acyl-CoA biosynthesis" "" "1" "0" "1.110" "1.045" "1.197" "1.225" "1.188" "1.183" "1.156" "1.116" "0.714" "229.8" "255.0" "240.2" "275.0" "281.5" "273.0" "271.9" "265.5" "256.5" "164.1" "" "" "" "" "" "" "" "" "" "" "207.4" "196.7" "185.8" "185.2" "234.8" "233.0" "230.7" "192.2" "173.0" "164.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8682459872602538883" "False" "High" "IsMasterProtein" "Q8N108" "Mesoderm induction early response protein 1 OS=Homo sapiens OX=9606 GN=MIER1 PE=1 SV=2" "0.000" "False" "28.606" "12" "5" "6" "5" "512" "57.9" "4.42" "19.51" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "57708" "ENSG00000198160" "MIER1" "C9JFD4; hsa:57708; Q08AE0; Q32NC4; Q5T104; Q5TAD1; Q5TAD2; Q5TAD4; Q5TAD5; Q6AHY8; Q86TB4; Q8N108; Q8N156; Q8N161; Q8NC37; Q8NES4; Q8NES5; Q8NES6; Q8WWG2; Q9HCG2" "" "" "0" "0" "1.085" "0.987" "1.228" "1.048" "1.144" "1.063" "0.985" "1.058" "1.500" "243.3" "264.1" "240.1" "298.9" "255.0" "278.3" "258.6" "239.6" "257.5" "365.0" "" "" "" "" "" "" "" "" "" "" "219.6" "203.7" "185.7" "201.3" "212.7" "237.6" "219.4" "173.4" "173.7" "365.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890686096526149286" "False" "High" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "0.000" "False" "28.559" "19" "6" "7" "6" "325" "36.5" "5.64" "24.65" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400, Pf12894" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.933" "0.817" "1.108" "0.870" "0.769" "0.963" "0.725" "0.845" "3.229" "186.4" "173.9" "152.3" "206.6" "162.2" "143.4" "179.5" "135.1" "157.5" "601.8" "" "" "" "" "" "" "" "" "" "" "168.3" "134.2" "117.8" "139.1" "135.3" "122.4" "152.3" "97.8" "106.3" "601.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492366251309725518" "False" "High" "IsMasterProtein" "Q9BZ23" "Pantothenate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PANK2 PE=1 SV=3" "0.000" "False" "28.552" "14" "6" "7" "3" "570" "62.6" "9.28" "23.15" "6" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf03630" "80025" "ENSG00000125779" "PANK2" "B1AK33; B2Z3X0; D3DVZ0; hsa:80025; Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9BZ23; Q9HAF2" "Coenzyme A biosynthesis" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "3" "1" "1.031" "0.791" "0.901" "0.917" "0.887" "0.998" "1.022" "1.001" "0.819" "202.6" "208.8" "160.2" "182.4" "185.7" "179.7" "202.2" "207.1" "202.7" "165.9" "" "" "" "" "" "" "" "" "" "" "182.8" "161.0" "123.9" "122.8" "154.9" "153.4" "171.5" "149.8" "136.7" "165.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869916031675078190" "False" "High" "IsMasterProtein" "O95486" "Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2" "0.000" "False" "28.501" "4" "4" "5" "4" "1093" "119.7" "7.66" "19.16" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10802" "ENSG00000113615" "SEC24A" "A8MVW3; hsa:10802; O95486; Q8WUV2; Q96GP7" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "0.865" "0.765" "0.968" "0.857" "0.791" "0.946" "0.826" "0.799" "2.490" "272.4" "235.7" "208.5" "263.9" "233.4" "215.6" "257.8" "224.9" "217.6" "678.3" "" "" "" "" "" "" "" "" "" "" "245.9" "181.8" "161.3" "177.7" "194.7" "184.0" "218.7" "162.8" "146.8" "678.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-630716066930521994" "False" "High" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "0.000" "False" "28.447" "27" "3" "23" "3" "195" "22.0" "5.44" "67.11" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "30" "0" "0.993" "0.815" "0.981" "0.982" "0.811" "0.945" "0.992" "0.828" "0.624" "991.5" "984.7" "807.8" "972.8" "974.2" "804.2" "937.2" "983.7" "821.3" "618.7" "" "" "" "" "" "" "" "" "" "" "895.0" "759.6" "624.8" "655.1" "812.6" "686.4" "795.0" "711.9" "554.0" "618.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4218486089971029806" "False" "High" "IsMasterProtein" "Q92608" "Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2" "0.000" "False" "28.440" "4" "7" "7" "7" "1830" "211.8" "6.87" "19.06" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "1794" "ENSG00000134516" "DOCK2" "hsa:1794; Q2M3I0; Q92608; Q96AK7" "RAC1 GTPase cycle; Neutrophil degranulation; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction" "Chemokine signaling pathway" "8" "0" "0.902" "0.785" "0.942" "0.929" "0.796" "0.975" "0.525" "0.859" "6.057" "254.4" "229.4" "199.7" "239.6" "236.2" "202.5" "248.1" "133.7" "218.6" "1540.8" "" "" "" "" "" "" "" "" "" "" "229.6" "176.9" "154.5" "161.4" "197.0" "172.8" "210.4" "96.7" "147.5" "1540.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9091705123101461009" "False" "High" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "0.000" "False" "28.428" "31" "3" "11" "3" "105" "11.7" "9.57" "34.14" "3" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "36" "0" "1.012" "1.167" "0.830" "1.112" "1.273" "1.053" "1.195" "1.072" "0.711" "369.8" "374.2" "431.5" "307.0" "411.1" "470.7" "389.4" "441.9" "396.3" "263.0" "" "" "" "" "" "" "" "" "" "" "333.8" "288.6" "333.7" "206.8" "342.9" "401.7" "330.3" "319.8" "267.3" "263.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299507636150983864" "False" "High" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "0.000" "False" "28.391" "15" "6" "8" "6" "457" "50.2" "8.31" "24.56" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "" "Iron-sulfur cluster biogenesis" "1" "0" "0.996" "1.053" "0.960" "1.136" "1.100" "1.048" "1.018" "1.094" "0.857" "352.3" "350.8" "370.9" "338.3" "400.3" "387.7" "369.3" "358.7" "385.4" "302.0" "" "" "" "" "" "" "" "" "" "" "318.0" "270.6" "286.9" "227.8" "333.9" "330.9" "313.2" "259.6" "259.9" "302.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "506200805167063951" "False" "High" "IsMasterProtein" "P42229" "Signal transducer and activator of transcription 5A OS=Homo sapiens OX=9606 GN=STAT5A PE=1 SV=1" "0.000" "False" "28.385" "7" "6" "7" "6" "794" "90.6" "6.39" "21.12" "6" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6776" "ENSG00000126561" "STAT5A" "hsa:6776; P42229; Q1KLZ6" "Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Nuclear signaling by ERBB4; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; Nuclear events stimulated by ALK signaling in cancer; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "IL-5 signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Puberty (Stage 2 of 4); Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; TYROBP causal network in microglia; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Th17 cell differentiation pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; Interferon type I signaling pathways; ErbB signaling pathway" "54" "0" "0.925" "0.982" "1.061" "0.966" "0.868" "1.033" "0.646" "0.919" "7.149" "187.7" "173.7" "184.4" "199.2" "181.3" "163.0" "193.9" "121.3" "172.5" "1342.0" "" "" "" "" "" "" "" "" "" "" "169.5" "134.0" "142.6" "134.1" "151.3" "139.1" "164.5" "87.8" "116.3" "1342.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7482655995969634953" "False" "High" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "0.000" "False" "28.296" "34" "4" "7" "4" "131" "13.8" "9.77" "21.08" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "1.050" "1.200" "1.048" "1.037" "1.100" "0.992" "1.087" "1.188" "0.740" "407.6" "428.0" "489.3" "427.3" "422.8" "448.6" "404.5" "443.1" "484.4" "301.6" "" "" "" "" "" "" "" "" "" "" "368.0" "330.2" "378.4" "287.7" "352.7" "382.9" "343.2" "320.6" "326.7" "301.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-715832753700784142" "False" "High" "IsMasterProtein" "P22830" "Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2" "0.000" "False" "28.153" "14" "6" "8" "6" "423" "47.8" "8.73" "24.26" "6" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00762" "2235" "ENSG00000066926" "FECH" "A8KA72; hsa:2235; P22830; Q8IXN1; Q8NAN0" "Mitochondrial protein degradation; Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "4" "0" "1.059" "1.054" "1.008" "1.012" "1.083" "1.024" "1.082" "1.102" "0.666" "297.3" "315.0" "313.5" "299.7" "301.0" "322.1" "304.5" "321.9" "327.5" "198.0" "" "" "" "" "" "" "" "" "" "" "268.4" "243.0" "242.5" "201.8" "251.1" "274.9" "258.3" "232.9" "220.9" "198.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2659505507426523226" "False" "High" "IsMasterProtein" "P0CAP2" "DNA-directed RNA polymerase II subunit GRINL1A OS=Homo sapiens OX=9606 GN=POLR2M PE=1 SV=1" "0.000" "False" "28.152" "17" "5" "5" "5" "368" "41.7" "6.39" "18.13" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15328" "81488" "ENSG00000255529" "POLR2M" "hsa:81488; P0CAP2; Q6EER8; Q6EES2; Q6EEV3; Q6EF00; Q6EF01; Q6EF02; Q6EF46; Q6EFN8; Q6EM48; Q6K046; Q6K050; Q6K051; Q6ZQZ3; Q8NC58; Q8NCF3; Q96DI5; Q96JB7; Q96NF5; Q9Y3V6" "" "" "0" "0" "1.303" "1.126" "1.226" "1.142" "1.220" "1.102" "1.039" "1.256" "1.077" "365.6" "476.5" "411.8" "448.2" "417.6" "446.0" "402.8" "379.7" "459.4" "393.6" "" "" "" "" "" "" "" "" "" "" "330.0" "367.5" "318.5" "301.8" "348.4" "380.7" "341.7" "274.8" "309.9" "393.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8349989266333908893" "False" "High" "IsMasterProtein" "P49841" "Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2" "0.000" "False" "28.139" "17" "6" "7" "3" "420" "46.7" "8.78" "25.76" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2932" "ENSG00000082701" "GSK3B" "D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47" "Regulation of HSF1-mediated heat shock response; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein" "IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)" "95" "2" "0.992" "0.881" "1.073" "1.007" "0.949" "1.038" "1.013" "0.893" "0.871" "488.9" "484.8" "430.9" "524.7" "492.5" "464.1" "507.2" "495.0" "436.8" "425.9" "" "" "" "" "" "" "" "" "" "" "441.3" "373.9" "333.3" "353.3" "410.8" "396.1" "430.3" "358.3" "294.6" "425.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848605729142375391" "False" "High" "IsMasterProtein" "P00813" "Adenosine deaminase OS=Homo sapiens OX=9606 GN=ADA PE=1 SV=3" "0.000" "False" "28.138" "22" "8" "11" "8" "363" "40.7" "5.95" "27.87" "8" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00962" "100" "ENSG00000196839" "ADA" "hsa:100; P00813; Q53F92; Q6LA59" "Ribavirin ADME; Purine salvage; Defective ADA disrupts (deoxy)adenosine deamination" "" "3" "0" "0.962" "1.042" "0.964" "1.016" "1.130" "0.997" "0.968" "1.048" "0.795" "588.3" "566.3" "613.2" "567.2" "597.6" "664.7" "586.5" "569.3" "616.5" "467.9" "" "" "" "" "" "" "" "" "" "" "531.1" "436.8" "474.3" "381.9" "498.5" "567.3" "497.6" "412.0" "415.8" "467.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3289616204838975461" "False" "High" "IsMasterProtein" "P62851" "Small ribosomal subunit protein eS25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "0.000" "False" "28.039" "37" "5" "16" "5" "125" "13.7" "10.11" "46.73" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.919" "0.963" "0.919" "1.056" "1.025" "1.008" "0.981" "1.014" "0.585" "617.9" "567.6" "594.9" "567.9" "652.4" "633.0" "622.8" "606.4" "626.4" "361.4" "" "" "" "" "" "" "" "" "" "" "557.7" "437.8" "460.1" "382.4" "544.2" "540.3" "528.3" "438.8" "422.5" "361.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407233124236787373" "False" "High" "IsMasterProtein" "Q96DB5" "Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1" "0.000" "False" "28.010" "21" "7" "9" "7" "314" "35.8" "8.50" "27.58" "7" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity" "Pf21033" "51115" "ENSG00000176623" "RMDN1" "A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; hsa:51115; Q96DB5; Q9Y398" "" "" "0" "0" "1.045" "0.758" "0.907" "1.013" "0.905" "0.935" "0.968" "0.874" "0.753" "224.7" "234.9" "170.4" "203.8" "227.6" "203.4" "210.1" "217.6" "196.3" "169.2" "" "" "" "" "" "" "" "" "" "" "202.8" "181.2" "131.8" "137.2" "189.9" "173.6" "178.2" "157.5" "132.4" "169.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "769140260772308897" "False" "High" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "0.000" "False" "28.002" "19" "6" "10" "6" "306" "33.7" "5.08" "25.68" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "6" "0" "0.995" "1.221" "1.114" "1.097" "1.064" "1.014" "0.781" "1.098" "5.756" "410.0" "407.9" "500.8" "456.7" "449.7" "436.4" "415.7" "320.2" "450.1" "2360.3" "" "" "" "" "" "" "" "" "" "" "370.1" "314.6" "387.3" "307.6" "375.1" "372.4" "352.6" "231.8" "303.6" "2360.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2253036871243965201" "False" "High" "IsMasterProtein" "Q15014" "Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1" "0.000" "False" "28.001" "18" "5" "7" "5" "288" "32.3" "9.72" "25.82" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf05712" "9643" "ENSG00000123562" "MORF4L2" "B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026" "HATs acetylate histones" "" "1" "0" "1.019" "0.935" "1.044" "1.038" "0.896" "1.012" "0.967" "0.901" "0.911" "448.5" "457.0" "419.5" "468.0" "465.4" "401.9" "454.1" "433.8" "403.9" "408.6" "" "" "" "" "" "" "" "" "" "" "404.8" "352.5" "324.5" "315.2" "388.2" "343.0" "385.2" "313.9" "272.4" "408.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4600920651766906085" "False" "High" "IsMasterProtein" "O14602" "Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AY PE=1 SV=4" "0.000" "False" "27.988" "31" "5" "16" "5" "144" "16.4" "5.24" "52.59" "5" "protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01176" "9086" "ENSG00000198692" "EIF1AY" "hsa:9086; O14602; Q9BS77" "" "Translation factors" "1" "0" "0.898" "0.888" "0.868" "0.936" "0.901" "0.901" "0.927" "0.899" "0.707" "578.8" "519.6" "513.9" "502.5" "541.6" "521.7" "521.3" "536.8" "520.5" "409.1" "" "" "" "" "" "" "" "" "" "" "522.4" "400.8" "397.4" "338.4" "451.8" "445.3" "442.2" "388.5" "351.1" "409.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5853240527723212968" "False" "High" "IsMasterProtein" "Q9H7Z7" "Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1" "0.000" "False" "27.978" "18" "7" "9" "7" "377" "41.9" "9.16" "26.33" "7" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf13410, Pf13417" "80142" "ENSG00000148334" "PTGES2" "hsa:80142; Q53EW9; Q5SYV6; Q96GI0; Q96GL2; Q9H7Z7" "Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Relationship between inflammation, COX-2 and EGFR; Omega-6-fatty acids in senescence" "4" "0" "1.002" "0.862" "0.894" "1.000" "0.818" "0.959" "1.016" "0.825" "0.731" "654.5" "655.5" "564.2" "585.5" "654.7" "535.4" "627.8" "665.2" "540.0" "478.4" "" "" "" "" "" "" "" "" "" "" "590.8" "505.6" "436.4" "394.3" "546.1" "457.0" "532.5" "481.4" "364.2" "478.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1695167521897825927" "False" "High" "IsMasterProtein" "P53609" "Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2" "0.000" "False" "27.967" "19" "7" "9" "7" "377" "42.3" "6.83" "31.03" "7" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00432" "5229" "ENSG00000164219" "PGGT1B" "hsa:5229; P53609; Q5MJP9" "" "" "0" "0" "1.050" "1.078" "1.013" "1.051" "0.962" "1.162" "1.172" "1.022" "0.835" "857.6" "900.4" "924.7" "868.5" "901.0" "824.6" "996.8" "1004.8" "876.2" "716.5" "" "" "" "" "" "" "" "" "" "" "774.1" "694.5" "715.2" "584.8" "751.6" "703.8" "845.5" "727.2" "591.0" "716.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5841636671217917151" "False" "High" "IsMasterProtein" "Q5JTJ3" "Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1" "0.000" "False" "27.966" "38" "4" "8" "4" "125" "14.1" "8.25" "28.32" "4" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf02297" "388753" "ENSG00000168275" "COA6" "hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88" "Mitochondrial protein import" "Mitochondrial complex IV assembly" "2" "0" "0.965" "0.770" "0.989" "0.921" "0.779" "0.943" "1.025" "0.841" "0.616" "587.0" "566.7" "452.2" "580.7" "540.5" "457.4" "553.3" "601.6" "493.9" "361.5" "" "" "" "" "" "" "" "" "" "" "529.9" "437.1" "349.8" "391.0" "450.9" "390.4" "469.4" "435.4" "333.1" "361.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8004592446864816783" "False" "High" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "0.000" "False" "27.959" "15" "6" "7" "4" "479" "52.6" "5.05" "19.30" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "MAPK signaling pathway" "4" "2" "0.969" "0.933" "0.862" "1.012" "1.037" "0.909" "0.972" "1.011" "0.715" "423.5" "410.2" "395.2" "364.9" "428.8" "439.0" "384.9" "411.8" "428.2" "302.6" "" "" "" "" "" "" "" "" "" "" "382.3" "316.4" "305.7" "245.7" "357.7" "374.7" "326.5" "298.0" "288.8" "302.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388316332710741736" "False" "High" "IsMasterProtein" "Q96FS4" "Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1" "0.000" "False" "27.933" "7" "6" "7" "6" "1042" "112.1" "6.60" "20.00" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf21022" "6494" "ENSG00000213445" "SIPA1" "hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4" "Rap1 signalling" "MAPK cascade" "2" "0" "1.037" "1.069" "1.063" "1.026" "1.073" "0.975" "0.909" "1.047" "1.140" "212.2" "219.9" "226.9" "225.5" "217.7" "227.6" "206.9" "192.8" "222.2" "241.9" "" "" "" "" "" "" "" "" "" "" "191.5" "169.6" "175.5" "151.9" "181.6" "194.2" "175.5" "139.5" "149.9" "241.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104369569183716546" "False" "High" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "0.000" "False" "27.926" "16" "8" "10" "8" "607" "68.6" "5.80" "27.62" "8" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "1.022" "0.802" "0.939" "1.070" "0.799" "1.023" "1.019" "0.811" "1.062" "516.2" "527.3" "414.2" "484.8" "552.1" "412.5" "528.2" "526.0" "418.7" "548.3" "" "" "" "" "" "" "" "" "" "" "465.9" "406.7" "320.3" "326.5" "460.6" "352.0" "448.1" "380.7" "282.4" "548.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7576876112341409561" "False" "High" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "0.000" "False" "27.904" "15" "6" "12" "6" "399" "45.3" "7.75" "38.30" "6" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "0.980" "0.972" "1.103" "0.998" "1.081" "0.955" "1.034" "1.017" "0.683" "799.4" "783.0" "777.0" "881.4" "798.1" "864.0" "763.1" "826.5" "813.4" "546.0" "" "" "" "" "" "" "" "" "" "" "721.6" "604.0" "600.9" "593.6" "665.8" "737.4" "647.3" "598.2" "548.6" "546.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7331213768411445402" "False" "High" "IsMasterProtein" "O95777" "U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3" "0.000" "False" "27.898" "69" "5" "9" "5" "96" "10.4" "4.48" "37.04" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51691" "ENSG00000128534" "LSM8" "hsa:51691; O95777" "mRNA Splicing - Major Pathway" "" "1" "0" "0.956" "1.016" "1.134" "0.984" "1.049" "0.977" "1.030" "1.060" "0.687" "367.6" "351.6" "373.5" "416.7" "361.8" "385.7" "359.2" "378.6" "389.7" "252.4" "" "" "" "" "" "" "" "" "" "" "331.8" "271.2" "288.8" "280.6" "301.8" "329.2" "304.7" "274.0" "262.9" "252.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830366311257218609" "False" "High" "IsMasterProtein" "P48147" "Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2" "0.000" "False" "27.876" "10" "6" "7" "6" "710" "80.6" "5.86" "24.61" "6" "protein metabolism" "cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf02897" "5550" "ENSG00000085377" "PREP" "hsa:5550; P48147; Q8N6D4" "" "" "0" "0" "0.953" "0.897" "0.919" "0.890" "1.007" "0.859" "0.912" "1.075" "2.669" "165.7" "158.0" "148.6" "152.2" "147.5" "166.9" "142.3" "151.1" "178.2" "442.3" "" "" "" "" "" "" "" "" "" "" "149.6" "121.9" "114.9" "102.5" "123.0" "142.5" "120.7" "109.4" "120.2" "442.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494127544242029271" "False" "High" "IsMasterProtein" "P62249" "Small ribosomal subunit protein uS9 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "0.000" "False" "27.846" "45" "8" "17" "8" "146" "16.4" "10.21" "48.40" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; SARS-CoV-1 modulates host translation machinery; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "19" "0" "0.952" "1.120" "0.964" "1.024" "1.013" "1.068" "0.982" "0.981" "0.584" "801.6" "763.1" "897.4" "773.1" "820.5" "811.7" "856.1" "787.4" "786.0" "467.9" "" "" "" "" "" "" "" "" "" "" "723.6" "588.6" "694.1" "520.6" "684.4" "692.8" "726.2" "569.8" "530.1" "467.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088218542987526353" "False" "High" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "0.000" "False" "27.820" "12" "5" "6" "5" "469" "51.3" "5.58" "21.32" "5" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Polymerase switching on the C-strand of the telomere; Polymerase switching" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "25" "0" "1.189" "0.852" "1.013" "1.041" "0.867" "1.149" "1.148" "0.841" "1.955" "155.8" "185.3" "132.8" "157.9" "162.3" "135.2" "179.1" "178.9" "131.0" "304.7" "" "" "" "" "" "" "" "" "" "" "140.7" "143.0" "102.7" "106.3" "135.4" "115.4" "151.9" "129.5" "88.4" "304.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2854050072506968056" "False" "High" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "0.000" "False" "27.789" "27" "7" "7" "7" "298" "32.8" "9.57" "21.17" "7" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "Base excision repair; DNA repair pathways, full network" "5" "0" "1.071" "0.875" "1.041" "1.125" "0.952" "0.910" "0.885" "0.966" "1.082" "299.2" "320.3" "261.8" "311.5" "336.8" "284.8" "272.4" "264.7" "289.0" "323.7" "" "" "" "" "" "" "" "" "" "" "270.1" "247.1" "202.5" "209.8" "280.9" "243.0" "231.1" "191.6" "194.9" "323.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1581896134396951467" "False" "High" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "0.000" "False" "27.773" "14" "2" "5" "2" "195" "19.5" "4.67" "26.79" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "1.076" "1.290" "1.040" "1.005" "1.119" "1.061" "1.211" "1.190" "0.778" "655.2" "705.3" "845.2" "681.7" "658.7" "733.2" "695.4" "793.8" "779.6" "509.5" "" "" "" "" "" "" "" "" "" "" "591.5" "544.0" "653.7" "459.1" "549.5" "625.8" "589.9" "574.5" "525.8" "509.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8295272483259113664" "False" "High" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "0.000" "False" "27.762" "39" "3" "16" "3" "95" "10.8" "6.52" "56.46" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "mRNA processing" "3" "0" "0.947" "1.095" "1.038" "1.013" "1.065" "0.966" "0.927" "1.041" "0.607" "583.0" "551.8" "638.4" "605.1" "590.6" "620.9" "563.1" "540.7" "606.6" "354.1" "" "" "" "" "" "" "" "" "" "" "526.3" "425.6" "493.8" "407.5" "492.6" "530.0" "477.7" "391.3" "409.2" "354.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7689745804882425318" "False" "High" "IsMasterProtein" "Q6XQN6" "Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2" "0.000" "False" "27.762" "10" "5" "6" "5" "538" "57.5" "5.68" "20.76" "5" "other metabolic processes;stress response" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf17767, Pf17956" "93100" "ENSG00000147813; ENSG00000278488" "NAPRT" "A7BFI3; hsa:93100; Q6PJL1; Q6XQN4; Q6XQN5; Q6XQN6; Q8N5E8; Q9BRG0" "Neutrophil degranulation; Nicotinamide salvaging" "NAD+ biosynthetic pathways" "3" "0" "1.054" "0.927" "0.982" "0.928" "0.987" "1.037" "0.977" "1.025" "0.714" "353.6" "372.8" "327.8" "347.3" "328.0" "349.2" "366.8" "345.3" "362.4" "252.5" "" "" "" "" "" "" "" "" "" "" "319.2" "287.6" "253.5" "233.9" "273.6" "298.0" "311.2" "249.9" "244.5" "252.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6090154179084716209" "False" "High" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "0.000" "False" "27.753" "16" "6" "7" "6" "454" "50.1" "8.25" "24.99" "6" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "1.033" "0.970" "1.187" "1.072" "1.076" "1.098" "1.042" "1.017" "0.749" "172.2" "177.9" "167.1" "204.3" "184.6" "185.2" "189.1" "179.4" "175.2" "128.9" "" "" "" "" "" "" "" "" "" "" "155.4" "137.2" "129.2" "137.6" "154.0" "158.1" "160.4" "129.8" "118.1" "128.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173318319984318675" "False" "High" "IsMasterProtein" "Q9BXR0" "Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3" "0.000" "False" "27.715" "12" "4" "5" "4" "403" "44.0" "7.23" "17.76" "4" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01702" "81890" "ENSG00000213339" "QTRT1" "B4DFM7; hsa:81890; Q96BQ4; Q9BXQ9; Q9BXR0" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.957" "0.968" "1.023" "1.091" "1.133" "1.024" "0.996" "1.057" "0.680" "259.6" "248.5" "251.4" "265.6" "283.3" "294.1" "265.8" "258.6" "274.5" "176.4" "" "" "" "" "" "" "" "" "" "" "234.3" "191.7" "194.4" "178.9" "236.3" "251.0" "225.5" "187.1" "185.1" "176.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137341147702067960" "False" "High" "IsMasterProtein" "P26440" "Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2" "0.000" "False" "27.698" "10" "4" "6" "4" "426" "46.6" "8.05" "17.99" "4" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "3712" "ENSG00000128928" "IVD" "B2RCV5; B3KVI7; hsa:3712; J3KR54; P26440; Q53XZ9; Q96AF6" "Branched-chain amino acid catabolism" "Valproic acid pathway" "2" "0" "0.886" "0.880" "0.936" "0.960" "0.932" "0.934" "0.984" "0.917" "0.721" "449.8" "398.7" "395.8" "420.9" "431.6" "419.1" "420.0" "442.7" "412.5" "324.4" "" "" "" "" "" "" "" "" "" "" "406.1" "307.5" "306.1" "283.5" "360.1" "357.7" "356.3" "320.4" "278.2" "324.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7841395992400372766" "False" "High" "IsMasterProtein" "Q9NVG8" "TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3" "0.000" "False" "27.683" "22" "8" "10" "8" "400" "46.5" "5.24" "30.32" "8" "transport" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00566" "54662" "ENSG00000107021" "TBC1D13" "A7E2E7; B3KW04; B9EGJ8; hsa:54662; Q5T270; Q5T271; Q9NVG8" "TBC/RABGAPs" "" "1" "0" "1.044" "0.975" "1.031" "0.998" "0.996" "1.067" "0.956" "0.972" "0.812" "226.5" "236.4" "220.9" "233.6" "226.1" "225.7" "241.7" "216.5" "220.1" "183.9" "" "" "" "" "" "" "" "" "" "" "204.5" "182.4" "170.9" "157.3" "188.6" "192.6" "205.0" "156.7" "148.5" "183.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6062730820723703914" "False" "High" "IsMasterProtein" "P82094" "TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2" "0.000" "False" "27.645" "8" "8" "8" "8" "1093" "122.8" "4.92" "22.29" "8" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf12325, Pf12329" "7110" "ENSG00000144747" "TMF1" "B7ZLJ2; hsa:7110; P82094; Q17R87; Q59GK0" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.067" "0.919" "1.287" "1.109" "1.058" "1.045" "1.014" "1.056" "0.773" "248.5" "265.3" "228.3" "319.8" "275.6" "263.0" "259.7" "252.0" "262.5" "192.2" "" "" "" "" "" "" "" "" "" "" "224.3" "204.6" "176.6" "215.4" "229.9" "224.5" "220.3" "182.4" "177.0" "192.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2160621710341352314" "False" "High" "IsMasterProtein" "O14964" "Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1" "0.000" "False" "27.636" "8" "7" "9" "7" "777" "86.1" "6.16" "28.86" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf01363, Pf12210" "9146" "ENSG00000185359" "HGS" "hsa:9146; O14964; Q9NR36" "Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway" "16" "0" "0.946" "1.091" "0.948" "1.007" "1.125" "0.970" "1.032" "1.109" "1.130" "612.0" "579.3" "667.9" "579.9" "616.3" "688.3" "593.9" "631.8" "679.0" "691.4" "" "" "" "" "" "" "" "" "" "" "552.5" "446.8" "516.6" "390.5" "514.1" "587.4" "503.8" "457.2" "458.0" "691.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7123841880797263349" "False" "High" "IsMasterProtein" "P09382" "Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2" "0.000" "False" "27.604" "46" "6" "11" "6" "135" "14.7" "5.50" "33.77" "6" "cell adhesion;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00337" "3956" "ENSG00000100097" "LGALS1" "B2R5E8; hsa:3956; P09382; Q9UDK5" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Immune infiltration in pancreatic cancer" "3" "0" "1.073" "1.124" "1.068" "1.129" "1.153" "1.093" "1.183" "1.194" "0.819" "872.6" "936.4" "980.5" "931.5" "984.9" "1006.0" "953.5" "1032.2" "1041.6" "714.6" "" "" "" "" "" "" "" "" "" "" "787.6" "722.3" "758.3" "627.3" "821.5" "858.7" "808.8" "747.0" "702.5" "714.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7337665348008384774" "False" "High" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "0.000" "False" "27.603" "10" "4" "5" "4" "494" "55.0" "7.12" "19.78" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "Formation of the active cofactor, UDP-glucuronate" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "3" "0" "0.970" "0.877" "1.026" "1.019" "0.785" "1.014" "0.994" "0.819" "0.724" "285.0" "276.5" "250.0" "292.4" "290.4" "223.8" "289.0" "283.2" "233.5" "206.4" "" "" "" "" "" "" "" "" "" "" "257.3" "213.3" "193.4" "196.9" "242.2" "191.0" "245.1" "205.0" "157.5" "206.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832676921386861974" "False" "High" "IsMasterProtein" "Q8WW33" "Gametocyte-specific factor 1 OS=Homo sapiens OX=9606 GN=GTSF1 PE=1 SV=2" "0.000" "False" "27.601" "32" "4" "8" "4" "167" "19.3" "6.51" "31.74" "4" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05253" "121355" "ENSG00000170627" "GTSF1" "B3KQ60; hsa:121355; Q0VGM4; Q8N778; Q8WW33" "" "" "0" "0" "1.007" "0.824" "1.122" "1.035" "0.785" "1.058" "1.108" "0.830" "0.680" "465.8" "469.0" "383.6" "522.5" "481.9" "365.5" "492.8" "515.9" "386.4" "316.7" "" "" "" "" "" "" "" "" "" "" "420.5" "361.8" "296.7" "351.9" "402.0" "311.9" "418.0" "373.3" "260.7" "316.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372358057775812967" "False" "High" "IsMasterProtein" "Q9UMZ2" "Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2" "0.000" "False" "27.538" "6" "7" "8" "7" "1314" "140.6" "5.03" "26.65" "7" "transport" "other membranes;ER/Golgi;other cell component" "" "" "11276" "ENSG00000274047; ENSG00000275066" "SYNRG" "A8MWU4; B7ZKZ2; B7ZKZ3; hsa:11276; Q17RI2; Q5BKU5; Q6ZT17; Q9UMZ2" "" "17q12 copy number variation syndrome" "1" "0" "1.036" "1.003" "1.004" "1.023" "0.978" "1.006" "1.011" "0.994" "1.004" "256.7" "265.9" "257.6" "257.7" "262.7" "251.2" "258.4" "259.6" "255.3" "257.9" "" "" "" "" "" "" "" "" "" "" "231.7" "205.1" "199.3" "173.5" "219.2" "214.4" "219.2" "187.8" "172.2" "257.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337195466672693139" "False" "High" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "0.000" "False" "27.532" "19" "5" "10" "4" "261" "29.3" "6.70" "32.70" "5" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Pyrimidine salvage" "Fluoropyrimidine activity; Pyrimidine metabolism" "3" "1" "0.958" "0.784" "0.970" "0.978" "0.773" "1.004" "1.038" "0.812" "0.781" "644.6" "617.7" "505.2" "625.3" "630.6" "498.2" "647.2" "669.3" "523.3" "503.3" "" "" "" "" "" "" "" "" "" "" "581.9" "476.5" "390.8" "421.1" "526.1" "425.2" "549.0" "484.4" "352.9" "503.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "280272277997118017" "False" "High" "IsMasterProtein" "Q9Y316" "Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1" "0.000" "False" "27.451" "18" "6" "8" "6" "297" "33.7" "7.14" "29.33" "6" "other biological processes" "" "" "Pf01875" "51072" "ENSG00000162959" "MEMO1" "B4DLS0; D6W575; hsa:51072; Q5R2V8; Q5R2V9; Q6NSL5; Q9Y316" "ERBB2 Regulates Cell Motility" "" "1" "0" "0.950" "0.899" "0.890" "0.955" "1.112" "0.897" "0.985" "1.102" "0.770" "359.8" "341.8" "323.5" "320.3" "343.7" "400.1" "322.7" "354.3" "396.6" "277.0" "" "" "" "" "" "" "" "" "" "" "324.8" "263.7" "250.2" "215.7" "286.7" "341.5" "273.8" "256.4" "267.5" "277.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7547854547274614235" "False" "High" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "0.000" "False" "27.413" "4" "4" "5" "4" "1059" "112.1" "7.30" "18.51" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "1.058" "0.815" "1.062" "1.046" "0.936" "1.010" "0.942" "0.923" "1.561" "284.7" "301.3" "232.1" "302.5" "298.0" "266.4" "287.5" "268.2" "262.9" "444.4" "" "" "" "" "" "" "" "" "" "" "257.0" "232.4" "179.5" "203.7" "248.6" "227.4" "243.8" "194.1" "177.3" "444.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "687508345564059484" "False" "High" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "0.000" "False" "27.366" "8" "6" "9" "5" "765" "86.1" "7.08" "27.22" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "1.065" "0.984" "1.007" "1.047" "0.958" "1.096" "0.996" "1.011" "1.661" "196.6" "209.5" "193.6" "198.1" "205.8" "188.3" "215.6" "195.9" "198.8" "326.7" "" "" "" "" "" "" "" "" "" "" "177.5" "161.6" "149.7" "133.4" "171.7" "160.7" "182.9" "141.8" "134.1" "326.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846678346596657924" "False" "High" "IsMasterProtein" "Q7L775" "EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1" "0.000" "False" "27.340" "15" "9" "10" "9" "607" "70.3" "6.11" "29.52" "9" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf18658" "9852" "ENSG00000178567" "EPM2AIP1" "hsa:9852; O94866; Q7L775; Q9H3L3" "" "" "0" "0" "0.981" "0.870" "1.028" "0.989" "0.903" "0.962" "0.975" "0.882" "0.974" "950.8" "933.2" "827.6" "977.4" "940.2" "858.9" "914.9" "927.1" "838.8" "926.4" "" "" "" "" "" "" "" "" "" "" "858.3" "719.8" "640.1" "658.2" "784.3" "733.1" "776.1" "671.0" "565.7" "926.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8070677658803742602" "False" "High" "IsMasterProtein" "P20585" "DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4" "0.000" "False" "27.330" "5" "6" "6" "6" "1137" "127.3" "8.02" "20.59" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05192" "4437" "ENSG00000113318" "MSH3" "A1L480; A1L482; A6NMM6; hsa:4437; P20585; Q6PJT5; Q86UQ6; Q92867" "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2" "Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network" "5" "0" "0.896" "0.664" "1.044" "0.892" "0.649" "0.850" "0.853" "0.756" "1.201" "200.8" "180.0" "133.4" "209.6" "179.1" "130.4" "170.6" "171.4" "151.8" "241.2" "" "" "" "" "" "" "" "" "" "" "181.3" "138.8" "103.2" "141.2" "149.4" "111.3" "144.7" "124.0" "102.4" "241.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-81494833362564834" "False" "High" "IsMasterProtein" "Q8WVJ2" "NudC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NUDCD2 PE=1 SV=1" "0.000" "False" "27.322" "29" "3" "5" "3" "157" "17.7" "5.07" "17.68" "3" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04969" "134492" "ENSG00000170584" "NUDCD2" "B2R4V0; hsa:134492; Q8WVJ2" "" "" "0" "0" "1.007" "0.772" "1.159" "1.092" "0.914" "1.042" "0.951" "1.027" "5.133" "101.5" "102.2" "78.3" "117.6" "110.9" "92.8" "105.7" "96.5" "104.2" "521.0" "" "" "" "" "" "" "" "" "" "" "91.6" "78.8" "60.6" "79.2" "92.5" "79.2" "89.7" "69.9" "70.3" "521.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4287058177622287432" "False" "High" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "0.000" "False" "27.294" "5" "3" "5" "2" "839" "94.5" "5.88" "21.35" "3" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "1.150" "0.769" "1.164" "0.988" "0.773" "1.251" "0.822" "0.811" "0.868" "62.6" "72.0" "48.2" "72.9" "61.9" "48.4" "78.4" "51.5" "50.8" "54.4" "" "" "" "" "" "" "" "" "" "" "56.5" "55.6" "37.3" "49.1" "51.6" "41.3" "66.5" "37.3" "34.3" "54.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8294412632701656103" "False" "High" "IsMasterProtein" "O60239" "SH3 domain-binding protein 5 OS=Homo sapiens OX=9606 GN=SH3BP5 PE=1 SV=2" "0.000" "False" "27.255" "12" "5" "6" "5" "455" "50.4" "4.97" "22.08" "5" "signal transduction" "other membranes;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05276" "9467" "ENSG00000131370" "SH3BP5" "B3KQW6; hsa:9467; O60239; Q5JWV9" "" "" "0" "0" "0.977" "0.867" "1.024" "1.066" "0.898" "1.049" "1.007" "1.005" "0.873" "263.1" "257.0" "228.1" "269.5" "280.5" "236.2" "276.1" "264.9" "264.5" "229.7" "" "" "" "" "" "" "" "" "" "" "237.5" "198.3" "176.4" "181.5" "234.0" "201.6" "234.2" "191.7" "178.4" "229.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8786307772961790223" "False" "High" "IsMasterProtein" "Q6QNY1" "Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Homo sapiens OX=9606 GN=BLOC1S2 PE=1 SV=1" "0.000" "False" "27.248" "17" "2" "4" "2" "142" "16.0" "4.86" "16.29" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf10046" "282991" "ENSG00000196072" "BLOC1S2" "B4DQV2; hsa:282991; Q5W040; Q6QNY1; Q8WUI8" "" "" "0" "0" "1.126" "1.048" "1.217" "1.201" "1.175" "1.091" "1.034" "1.048" "0.783" "79.2" "89.1" "83.0" "96.4" "95.1" "93.1" "86.4" "81.9" "83.0" "62.0" "" "" "" "" "" "" "" "" "" "" "71.5" "68.8" "64.2" "64.9" "79.4" "79.4" "73.3" "59.3" "56.0" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2794156240078795368" "False" "High" "IsMasterProtein" "Q8NEZ5" "F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1" "0.000" "False" "27.232" "16" "6" "7" "6" "403" "44.5" "7.03" "19.87" "6" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00646, Pf10442" "26263" "ENSG00000167196" "FBXO22" "hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.119" "0.806" "1.037" "1.272" "0.981" "1.040" "1.111" "0.983" "0.780" "130.1" "145.6" "104.8" "135.0" "165.6" "127.6" "135.3" "144.5" "127.9" "101.5" "" "" "" "" "" "" "" "" "" "" "117.5" "112.3" "81.1" "90.9" "138.1" "108.9" "114.8" "104.6" "86.3" "101.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2708632979130541749" "False" "High" "IsMasterProtein" "Cont_P02584" "Profilin-1 OS=Bos taurus OX=9913 GN=PFN1 PE=1 SV=2" "0.000" "True" "27.181" "31" "4" "14" "1" "140" "15.0" "8.28" "37.69" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00235" "102175326; 104993965; 109573782; 513895" "ENSBGRG00000026249; ENSBIXG00000014601; ENSBIXG00005028693; ENSBTAG00000004915; ENSCHIG00000025972; ENSMMSG00000006925" "PFN1" "A0A212D7Q6; A0A452G587; A0A4W2IHQ6; A0A5N3WG60; A0A5N3X3I9; A0A6B0S5H7; A0A6J0Z611; A0A6P3HSX5; A0A6P5DHW6; A0A8B9YVA5; A0A8C6DAC0; bbis:104993965; biu:109573782; bta:513895; chx:102175326; P02584; Q3ZCH4; Q5E942" "PCP/CE pathway; RHO GTPases Activate Formins" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2971731893176673056" "False" "High" "IsMasterProtein" "O15305" "Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1" "0.000" "False" "27.156" "20" "5" "10" "5" "246" "28.1" "6.77" "32.57" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03332" "5373" "ENSG00000140650" "PMM2" "A8K672; B7Z6R0; D3DUF3; hsa:5373; O15305" "Defective PMM2 causes PMM2-CDG; Synthesis of GDP-mannose" "Nephrotic syndrome; N-glycan biosynthesis; Primary ovarian insufficiency" "5" "0" "0.951" "0.972" "0.947" "0.947" "0.995" "1.008" "0.951" "1.040" "0.745" "646.9" "615.4" "628.9" "612.7" "612.4" "643.9" "651.9" "615.5" "672.6" "482.1" "" "" "" "" "" "" "" "" "" "" "584.0" "474.7" "486.4" "412.6" "510.8" "549.6" "553.0" "445.4" "453.7" "482.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697340015663074004" "False" "High" "IsMasterProtein" "P56211" "cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2" "0.000" "False" "27.130" "33" "3" "10" "2" "112" "12.3" "9.09" "31.64" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "10776" "ENSG00000128989" "ARPP19" "B2R497; hsa:10776; P56211; Q6IAM2; Q86TA6; Q9UD70" "MASTL Facilitates Mitotic Progression" "" "1" "0" "0.966" "0.803" "1.003" "0.890" "0.750" "0.916" "0.947" "0.884" "0.683" "493.7" "476.8" "396.6" "495.1" "439.3" "370.3" "452.1" "467.4" "436.5" "337.3" "" "" "" "" "" "" "" "" "" "" "445.6" "367.8" "306.7" "333.4" "366.4" "316.0" "383.5" "338.3" "294.4" "337.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1732426368668540463" "False" "High" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "0.000" "False" "27.097" "37" "4" "7" "4" "165" "19.0" "5.21" "25.03" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "1.095" "0.973" "0.976" "0.884" "0.984" "0.969" "0.895" "1.055" "0.860" "205.6" "225.0" "200.1" "200.6" "181.8" "202.4" "199.1" "183.9" "216.9" "176.9" "" "" "" "" "" "" "" "" "" "" "185.5" "173.5" "154.8" "135.1" "151.6" "172.7" "168.9" "133.1" "146.3" "176.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741204735065001472" "False" "High" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "0.000" "False" "27.091" "11" "5" "8" "5" "523" "58.7" "6.67" "24.39" "5" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "0" "1.005" "1.063" "1.089" "1.114" "1.141" "1.036" "0.937" "1.068" "2.814" "388.8" "390.7" "413.5" "423.3" "433.2" "443.7" "402.7" "364.3" "415.2" "1094.3" "" "" "" "" "" "" "" "" "" "" "351.0" "301.3" "319.8" "285.0" "361.4" "378.7" "341.6" "263.7" "280.0" "1094.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978965257736533934" "False" "High" "IsMasterProtein" "Q9NYK5" "Large ribosomal subunit protein mL39 OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "0.000" "False" "27.064" "18" "6" "8" "6" "338" "38.7" "7.65" "24.85" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.916" "0.885" "0.972" "0.941" "0.874" "1.012" "0.845" "0.911" "0.874" "280.2" "256.6" "247.9" "272.2" "263.8" "245.0" "283.5" "236.7" "255.3" "244.9" "" "" "" "" "" "" "" "" "" "" "252.9" "198.0" "191.7" "183.3" "220.0" "209.1" "240.5" "171.3" "172.2" "244.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2031700092780878303" "False" "High" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "0.000" "False" "27.056" "37" "3" "8" "3" "95" "10.5" "8.18" "22.53" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "Mitochondrial protein import" "" "1" "0" "1.064" "1.001" "1.267" "1.010" "0.995" "0.955" "1.103" "0.861" "0.583" "239.3" "254.7" "239.6" "303.3" "241.8" "238.3" "228.6" "264.1" "206.2" "139.4" "" "" "" "" "" "" "" "" "" "" "216.1" "196.5" "185.4" "204.3" "201.7" "203.4" "193.9" "191.1" "139.1" "139.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5104868076877432039" "False" "High" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "0.000" "False" "27.026" "16" "5" "7" "5" "313" "34.8" "5.60" "23.81" "5" "" "mitochondrion" "" "Pf21207, Pf21701" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "0.845" "1.020" "0.874" "0.911" "1.055" "0.901" "0.852" "0.998" "1.599" "501.9" "424.4" "512.1" "438.5" "457.2" "529.6" "452.1" "427.4" "500.7" "802.7" "" "" "" "" "" "" "" "" "" "" "453.1" "327.3" "396.1" "295.3" "381.4" "452.0" "383.5" "309.3" "337.7" "802.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421392599925785436" "False" "High" "IsMasterProtein" "Q9HD15" "Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=2" "0.000" "False" "27.021" "26" "5" "9" "5" "224" "24.4" "7.50" "29.77" "5" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07304" "10011" "ENSG00000213523" "SRA1" "hsa:10011; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14; Q9HD15" "" "" "0" "0" "0.898" "0.824" "1.037" "0.876" "0.860" "0.853" "0.926" "0.896" "0.712" "927.0" "832.5" "763.4" "961.4" "812.0" "797.0" "790.6" "858.3" "830.3" "659.7" "" "" "" "" "" "" "" "" "" "" "836.7" "642.2" "590.5" "647.4" "677.4" "680.3" "670.7" "621.1" "560.0" "659.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7827642572833014462" "False" "High" "IsMasterProtein" "P14649" "Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1" "0.000" "False" "27.009" "22" "4" "14" "2" "208" "22.8" "5.73" "39.18" "4" "other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "140465" "ENSG00000196465" "MYL6B" "hsa:140465; P14649" "Smooth Muscle Contraction" "Ciliary landscape" "2" "0" "0.973" "0.789" "0.847" "1.016" "0.724" "1.144" "0.731" "0.779" "0.710" "27.9" "27.1" "22.0" "23.6" "28.3" "20.2" "31.9" "20.4" "21.7" "19.8" "" "" "" "" "" "" "" "" "" "" "25.2" "20.9" "17.0" "15.9" "23.6" "17.2" "27.0" "14.8" "14.7" "19.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5541233720560719878" "False" "High" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "0.000" "False" "27.009" "33" "8" "12" "8" "227" "26.2" "8.82" "33.51" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "5" "0" "1.016" "0.973" "1.047" "1.052" "1.039" "0.893" "0.970" "0.963" "0.626" "666.9" "677.3" "648.7" "698.3" "701.4" "692.6" "595.7" "646.9" "642.3" "417.3" "" "" "" "" "" "" "" "" "" "" "602.0" "522.5" "501.7" "470.2" "585.1" "591.2" "505.3" "468.2" "433.3" "417.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8732346175470674622" "False" "High" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "0.000" "False" "26.977" "5" "8" "8" "7" "1357" "156.2" "5.64" "22.55" "8" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOG GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RHO GTPases activate KTN1" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "11" "0" "0.915" "2.072" "1.003" "1.063" "2.026" "1.003" "0.986" "2.106" "2.025" "242.4" "221.8" "502.2" "243.0" "257.6" "491.1" "243.2" "239.0" "510.6" "490.7" "" "" "" "" "" "" "" "" "" "" "218.8" "171.1" "388.5" "163.6" "214.9" "419.2" "206.3" "172.9" "344.4" "490.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5798091253452066801" "False" "High" "IsMasterProtein" "Cont_Q86YZ3" "Hornerin OS=Homo sapiens OX=9606 GN=HRNR PE=1 SV=2" "0.000" "True" "26.965" "8" "6" "7" "6" "2850" "282.2" "10.04" "19.52" "6" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01023" "388697" "ENSG00000197915" "HRNR" "hsa:388697; Q5DT20; Q5U1F4; Q86YZ3" "Neutrophil degranulation" "" "1" "0" "1.032" "1.499" "0.662" "0.562" "0.510" "0.709" "0.439" "0.829" "0.642" "100.2" "103.4" "150.2" "66.3" "56.3" "51.1" "71.1" "44.0" "83.1" "64.3" "" "" "" "" "" "" "" "" "" "" "90.4" "79.8" "116.2" "44.6" "47.0" "43.6" "60.3" "31.9" "56.0" "64.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7873771796286241695" "False" "High" "IsMasterProtein" "A6NHL2" "Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2" "0.000" "False" "26.943" "7" "3" "20" "1" "446" "49.9" "6.05" "62.41" "3" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "79861" "ENSG00000178462" "TUBAL3" "A6NHL2; B4DKL2; hsa:79861; Q4QQJ5; Q9H6Z0" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "32" "0" "1.253" "1.262" "1.084" "1.292" "1.271" "1.723" "1.151" "1.113" "0.924" "81.7" "102.3" "103.1" "88.5" "105.5" "103.8" "140.7" "94.0" "90.9" "75.5" "" "" "" "" "" "" "" "" "" "" "73.7" "78.9" "79.8" "59.6" "88.0" "88.6" "119.4" "68.0" "61.3" "75.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6767865713948388298" "False" "High" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "0.000" "False" "26.917" "27" "5" "9" "5" "205" "22.9" "6.55" "30.14" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.957" "1.023" "0.997" "1.007" "1.094" "0.970" "0.943" "1.031" "0.698" "519.5" "497.1" "531.2" "517.9" "522.9" "568.1" "503.8" "489.6" "535.8" "362.7" "" "" "" "" "" "" "" "" "" "" "468.9" "383.4" "410.9" "348.7" "436.2" "484.8" "427.4" "354.3" "361.4" "362.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3690320084066520669" "False" "High" "IsMasterProtein" "Cont_P04259" "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" "0.000" "True" "26.905" "11" "7" "11" "2" "564" "60.0" "8.00" "33.52" "7" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3854" "ENSG00000185479" "KRT6B" "hsa:3854; P04259; P48669" "Formation of the cornified envelope" "" "2" "0" "0.531" "1.251" "0.294" "0.504" "0.429" "0.290" "0.342" "0.401" "0.346" "108.9" "57.8" "136.1" "32.1" "54.8" "46.7" "31.6" "37.2" "43.6" "37.7" "" "" "" "" "" "" "" "" "" "" "98.3" "44.6" "105.3" "21.6" "45.7" "39.9" "26.8" "26.9" "29.4" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4736314326613788604" "False" "High" "IsMasterProtein" "P62277" "Small ribosomal subunit protein uS15 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2" "0.000" "False" "26.886" "34" "6" "14" "6" "151" "17.2" "10.54" "39.19" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00312, Pf08069" "6207" "ENSG00000110700" "RPS13" "B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Selenocysteine synthesis; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.634" "1.025" "0.690" "0.642" "0.960" "0.663" "0.784" "0.602" "0.376" "862.2" "546.6" "883.8" "594.9" "553.4" "827.8" "571.9" "675.6" "519.2" "323.8" "" "" "" "" "" "" "" "" "" "" "778.3" "421.6" "683.6" "400.6" "461.6" "706.5" "485.1" "488.9" "350.2" "323.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2548334964560567831" "False" "High" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "0.000" "False" "26.849" "16" "7" "9" "7" "377" "41.9" "6.65" "27.70" "7" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "1.014" "1.091" "1.141" "1.029" "1.092" "1.105" "1.075" "1.109" "0.803" "668.5" "677.6" "729.1" "762.6" "687.9" "729.7" "738.6" "719.0" "741.3" "536.8" "" "" "" "" "" "" "" "" "" "" "603.5" "522.7" "563.9" "513.5" "573.8" "622.8" "626.5" "520.3" "500.0" "536.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176127761844367310" "False" "High" "IsMasterProtein" "Q9H2G2" "STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1" "0.000" "False" "26.786" "6" "7" "7" "7" "1235" "142.6" "5.15" "22.64" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "9748" "ENSG00000065613" "SLK" "D3DRA0; D3DRA1; hsa:9748; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9H2G2; Q9NQL0; Q9NQL1" "RHOA GTPase cycle; RHOC GTPase cycle; RHOB GTPase cycle" "TAR syndrome" "4" "0" "0.898" "0.838" "0.982" "0.854" "0.818" "0.932" "0.813" "0.813" "0.960" "402.8" "361.6" "337.5" "395.5" "344.1" "329.5" "375.5" "327.6" "327.4" "386.9" "" "" "" "" "" "" "" "" "" "" "363.6" "278.9" "261.1" "266.3" "287.0" "281.3" "318.5" "237.1" "220.8" "386.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818907558764607522" "False" "High" "IsMasterProtein" "Q8IWD4" "Coiled-coil domain-containing protein 117 OS=Homo sapiens OX=9606 GN=CCDC117 PE=1 SV=1" "0.000" "False" "26.754" "19" "5" "8" "5" "279" "30.5" "5.07" "27.15" "5" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf15810" "150275" "ENSG00000159873" "CCDC117" "A8K0F1; B7Z2V1; B7Z860; hsa:150275; Q6ICA7; Q8IWD4; Q8N278" "" "" "0" "0" "0.883" "0.811" "0.947" "0.864" "0.817" "0.873" "1.046" "0.699" "0.637" "519.9" "459.3" "421.4" "492.6" "449.0" "424.8" "453.9" "543.7" "363.3" "331.0" "" "" "" "" "" "" "" "" "" "" "469.3" "354.3" "326.0" "331.7" "374.5" "362.6" "385.1" "393.5" "245.1" "331.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8811809090486028216" "False" "High" "IsMasterProtein" "Q6QNY0" "Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1" "0.000" "False" "26.746" "26" "4" "6" "4" "202" "21.2" "5.15" "19.98" "4" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cell component" "transporter activity" "Pf15753" "388552" "ENSG00000189114" "BLOC1S3" "B2RXB8; hsa:388552; Q6QNY0" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "0.951" "0.891" "1.055" "1.034" "0.966" "0.991" "0.934" "1.000" "0.921" "111.2" "105.8" "99.1" "117.3" "115.0" "107.4" "110.2" "103.9" "111.2" "102.5" "" "" "" "" "" "" "" "" "" "" "100.4" "81.6" "76.6" "79.0" "95.9" "91.7" "93.5" "75.2" "75.0" "102.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "854871700707894946" "False" "High" "IsMasterProtein" "Q9NZL4" "Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2" "0.000" "False" "26.742" "19" "6" "11" "6" "359" "39.3" "5.21" "35.10" "6" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf08609" "23640" "ENSG00000133265" "HSPBP1" "B3KQP0; B4DG11; hsa:23640; O95351; Q6ZNU5; Q9NZL4" "" "" "0" "0" "0.956" "1.129" "1.028" "0.938" "1.049" "0.933" "0.869" "1.117" "1.504" "374.3" "357.9" "422.8" "384.8" "351.2" "392.8" "349.2" "325.2" "418.2" "562.9" "" "" "" "" "" "" "" "" "" "" "337.9" "276.1" "327.0" "259.2" "292.9" "335.3" "296.2" "235.4" "282.1" "562.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6087199310060456450" "False" "High" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "0.000" "False" "26.733" "22" "2" "5" "2" "125" "14.2" "5.26" "22.33" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "Eukaryotic Translation Termination; tRNA modification in the nucleus and cytosol; rRNA modification in the nucleus and cytosol; Methylation" "" "4" "0" "0.984" "0.867" "0.962" "0.943" "0.912" "0.945" "0.962" "0.898" "0.782" "390.6" "384.5" "338.5" "375.9" "368.2" "356.2" "369.0" "375.8" "350.7" "305.6" "" "" "" "" "" "" "" "" "" "" "352.6" "296.6" "261.8" "253.1" "307.1" "304.0" "313.0" "271.9" "236.6" "305.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4559140579210949167" "False" "High" "IsMasterProtein" "P62917" "Large ribosomal subunit protein uL2 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "0.000" "False" "26.687" "22" "6" "12" "6" "257" "28.0" "11.03" "38.65" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Protein hydroxylation; Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "15" "0" "0.923" "1.094" "0.945" "0.995" "0.961" "0.999" "1.101" "1.003" "0.321" "722.6" "666.8" "790.7" "682.5" "718.7" "694.3" "722.1" "795.6" "724.7" "232.3" "" "" "" "" "" "" "" "" "" "" "652.3" "514.3" "611.6" "459.6" "599.5" "592.6" "612.5" "575.7" "488.8" "232.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066776278631376418" "False" "High" "IsMasterProtein" "P17612" "cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2" "0.000" "False" "26.641" "17" "6" "9" "1" "351" "40.6" "8.79" "30.96" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5566" "ENSG00000072062; ENSG00000288516" "PRKACA" "hsa:5566; P17612; Q32P54; Q9H2Y0; Q9NRB4; Q9NRH9" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Mitochondrial protein degradation; FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Phosphodiesterases in neuronal function; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; GDNF signaling; Urotensin-II-mediated signaling pathway; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "75" "0" "0.928" "0.931" "1.449" "1.070" "1.103" "1.019" "1.117" "1.226" "0.977" "41.4" "38.5" "38.6" "60.0" "44.4" "45.7" "42.2" "46.3" "50.8" "40.5" "" "" "" "" "" "" "" "" "" "" "37.4" "29.7" "29.8" "40.4" "37.0" "39.0" "35.8" "33.5" "34.3" "40.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120785921578449656" "False" "High" "IsMasterProtein" "A0A0B4J2D5" "Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=5 SV=1" "0.000" "False" "26.632" "23" "6" "6" "6" "268" "28.1" "8.27" "21.21" "6" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "" "Gastric cancer network 1" "1" "0" "1.014" "0.984" "0.952" "0.970" "1.051" "0.967" "0.984" "1.009" "0.794" "426.2" "432.0" "419.4" "405.8" "413.2" "447.7" "412.2" "419.4" "430.1" "338.4" "" "" "" "" "" "" "" "" "" "" "384.7" "333.2" "324.4" "273.2" "344.7" "382.1" "349.7" "303.5" "290.1" "338.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013273140133158732" "False" "High" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "0.000" "False" "26.532" "7" "2" "4" "2" "528" "60.6" "5.06" "20.28" "2" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "1.056" "1.180" "1.033" "0.786" "1.313" "0.936" "0.899" "1.118" "1.349" "65.2" "68.9" "77.0" "67.4" "51.3" "85.7" "61.1" "58.6" "72.9" "88.0" "" "" "" "" "" "" "" "" "" "" "58.9" "53.2" "59.6" "45.4" "42.8" "73.1" "51.8" "42.4" "49.2" "88.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9042131036706186365" "False" "High" "IsMasterProtein" "Q13485" "Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1" "0.000" "False" "26.514" "12" "6" "9" "6" "552" "60.4" "6.99" "28.00" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4089" "ENSG00000141646" "SMAD4" "A8K405; hsa:4089; Q13485" "Ub-specific processing proteases; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by BMP; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Transcriptional regulation of pluripotent stem cells; RUNX3 regulates BCL2L11 (BIM) transcription; RUNX2 regulates bone development; Signaling by Activin; TGF-beta receptor signaling activates SMADs; RUNX3 regulates CDKN1A transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Heart development; Cell cycle; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Progeria-associated lipodystrophy; Clock-controlled autophagy in bone metabolism; Rubinstein-Taybi syndrome 1; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "53" "0" "0.953" "0.858" "1.063" "1.025" "0.943" "1.021" "0.962" "0.913" "0.996" "749.3" "714.1" "643.1" "796.8" "767.9" "706.5" "764.7" "720.5" "684.2" "746.2" "" "" "" "" "" "" "" "" "" "" "676.4" "550.8" "497.4" "536.6" "640.5" "603.0" "648.7" "521.4" "461.5" "746.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8263646129409186084" "False" "High" "IsMasterProtein" "Q14814" "Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1" "0.000" "False" "26.508" "11" "6" "11" "5" "521" "55.9" "7.88" "36.24" "6" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4209" "ENSG00000116604; ENSG00000291761" "MEF2D" "D3DVC0; hsa:4209; Q14814; Q14815; Q5T9U5; Q5T9U6" "NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "18" "1" "1.058" "1.028" "1.076" "1.027" "0.992" "1.081" "1.062" "1.011" "0.819" "1009.3" "1067.5" "1037.6" "1085.6" "1036.7" "1001.3" "1090.6" "1072.2" "1020.8" "826.7" "" "" "" "" "" "" "" "" "" "" "911.1" "823.4" "802.5" "731.0" "864.7" "854.6" "925.2" "775.9" "688.5" "826.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "499510966834701259" "False" "High" "IsMasterProtein" "Q96GS4" "BLOC-1-related complex subunit 6 OS=Homo sapiens OX=9606 GN=BORCS6 PE=1 SV=2" "0.000" "False" "26.470" "12" "3" "5" "3" "357" "37.2" "5.76" "20.44" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10157" "54785" "ENSG00000196544" "BORCS6" "hsa:54785; Q53HS4; Q96GS4; Q9NXW8" "" "" "0" "0" "1.221" "1.421" "1.429" "1.257" "1.271" "1.343" "1.426" "1.543" "1.001" "75.0" "91.6" "106.6" "107.2" "94.3" "95.4" "100.7" "107.0" "115.7" "75.1" "" "" "" "" "" "" "" "" "" "" "67.7" "70.7" "82.5" "72.2" "78.6" "81.4" "85.4" "77.4" "78.0" "75.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153257875265109999" "False" "High" "IsMasterProtein" "Q9NYJ1" "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2" "0.000" "False" "26.416" "29" "3" "8" "3" "87" "10.1" "6.04" "25.79" "3" "cell organization and biogenesis" "mitochondrion" "" "Pf06747" "51287" "ENSG00000181924" "COA4" "B2RAA0; hsa:51287; Q69YU4; Q9NYJ1" "Mitochondrial protein import" "" "1" "0" "0.908" "0.854" "1.017" "0.968" "0.843" "0.900" "1.050" "0.901" "0.930" "470.2" "426.9" "401.7" "478.3" "455.3" "396.3" "423.2" "493.7" "423.8" "437.1" "" "" "" "" "" "" "" "" "" "" "424.4" "329.3" "310.7" "322.1" "379.8" "338.3" "359.0" "357.3" "285.8" "437.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7829507115951982075" "False" "High" "IsMasterProtein" "P19387" "DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens OX=9606 GN=POLR2C PE=1 SV=2" "0.000" "False" "26.407" "22" "5" "8" "5" "275" "31.4" "4.92" "20.51" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "5432" "ENSG00000102978" "POLR2C" "hsa:5432; O15161; P19387" "TP53 Regulates Transcription of DNA Repair Genes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Primary ovarian insufficiency" "44" "0" "0.947" "0.817" "1.018" "0.976" "0.866" "0.954" "0.966" "0.881" "1.011" "226.8" "214.7" "185.3" "230.8" "221.2" "196.3" "216.3" "219.0" "199.8" "229.3" "" "" "" "" "" "" "" "" "" "" "204.7" "165.6" "143.3" "155.4" "184.6" "167.5" "183.4" "158.5" "134.8" "229.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7333180136300150104" "False" "High" "IsMasterProtein" "Q96S44" "EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2" "0.000" "False" "26.379" "19" "4" "8" "4" "253" "28.1" "9.54" "23.68" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf06293" "112858" "ENSG00000172315" "TP53RK" "B3KU44; hsa:112858; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q96S44; Q9NQE6" "Regulation of TP53 Activity through Phosphorylation; tRNA modification in the nucleus and cytosol" "" "2" "0" "0.953" "1.033" "0.956" "1.025" "0.976" "0.948" "0.950" "0.887" "0.792" "371.4" "354.1" "383.5" "355.0" "380.6" "362.5" "352.0" "352.9" "329.4" "294.0" "" "" "" "" "" "" "" "" "" "" "335.2" "273.1" "296.6" "239.1" "317.4" "309.4" "298.6" "255.4" "222.2" "294.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6144698658960758490" "False" "High" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "0.000" "False" "26.318" "6" "4" "6" "4" "793" "91.0" "7.18" "17.97" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "1.062" "1.046" "1.031" "1.128" "1.120" "1.052" "1.093" "1.188" "0.887" "148.2" "157.5" "155.0" "152.8" "167.2" "166.0" "155.9" "162.0" "176.1" "131.4" "" "" "" "" "" "" "" "" "" "" "133.8" "121.5" "119.9" "102.9" "139.5" "141.7" "132.2" "117.2" "118.8" "131.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8311044657227682609" "False" "High" "IsMasterProtein" "Q9BZE9" "Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1" "0.000" "False" "26.273" "13" "6" "9" "6" "553" "60.1" "6.64" "28.09" "6" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf00789, Pf11470" "79058" "ENSG00000169696" "ASPSCR1" "A8K3K9; hsa:79058; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; Q9BZE9" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "1.000" "1.080" "1.138" "0.902" "0.905" "1.052" "1.035" "1.038" "0.971" "123.8" "123.8" "133.7" "140.9" "111.7" "112.0" "130.2" "128.1" "128.5" "120.1" "" "" "" "" "" "" "" "" "" "" "111.7" "95.5" "103.4" "94.9" "93.2" "95.6" "110.5" "92.7" "86.6" "120.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2834511568131292996" "False" "High" "IsMasterProtein" "O00329" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2" "0.000" "False" "26.191" "9" "10" "11" "10" "1044" "119.4" "7.18" "29.13" "10" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5293" "ENSG00000171608" "PIK3CD" "A6NCG0; G1FFP1; hsa:5293; O00329; O15445; Q5SR49" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; IL-3 signaling pathway; Focal adhesion; Overview of nanoparticle effects; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "56" "0" "0.958" "0.706" "0.977" "0.975" "0.763" "0.943" "0.930" "0.763" "1.199" "421.9" "404.3" "298.0" "412.2" "411.2" "321.8" "398.1" "392.3" "322.1" "506.1" "" "" "" "" "" "" "" "" "" "" "380.9" "311.8" "230.5" "277.6" "343.0" "274.7" "337.7" "283.9" "217.3" "506.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644721245290312006" "False" "High" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "0.000" "False" "26.183" "13" "6" "9" "6" "423" "47.8" "6.65" "27.79" "6" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf21215" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "6" "0" "1.029" "0.982" "0.937" "1.073" "1.030" "1.074" "1.071" "0.949" "0.773" "457.5" "470.5" "449.4" "428.6" "490.9" "471.2" "491.1" "489.8" "433.9" "353.8" "" "" "" "" "" "" "" "" "" "" "412.9" "362.9" "347.5" "288.6" "409.5" "402.2" "416.6" "354.4" "292.7" "353.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144550306187805462" "False" "High" "IsMasterProtein" "Q68E01" "Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1" "0.000" "False" "26.179" "7" "6" "6" "6" "1043" "118.0" "5.80" "19.24" "6" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf10189" "65123" "ENSG00000143624; ENSG00000262826" "INTS3" "A8K1W0; B4DQC8; B4E3U9; D3DV57; hsa:65123; Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q68E01; Q69YR5; Q6AI57; Q6DKG7; Q6MZQ4; Q6MZZ9; Q8NC46; Q8TB23; Q9H6S9" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "0.800" "1.367" "1.111" "1.019" "1.316" "0.993" "0.890" "1.348" "1.498" "142.1" "113.6" "194.3" "157.8" "144.8" "187.0" "141.0" "126.5" "191.5" "212.9" "" "" "" "" "" "" "" "" "" "" "128.2" "87.6" "150.3" "106.3" "120.8" "159.6" "119.6" "91.5" "129.2" "212.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1483529755144940188" "False" "High" "IsMasterProtein" "P78324" "Tyrosine-protein phosphatase non-receptor type substrate 1 OS=Homo sapiens OX=9606 GN=SIRPA PE=1 SV=2" "0.000" "False" "26.176" "12" "5" "5" "5" "504" "54.9" "6.98" "18.15" "5" "cell adhesion;stress response;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf07654, Pf07686" "140885" "ENSG00000198053" "SIRPA" "A2A2E1; A8K411; B2R6C3; hsa:140885; O00683; O43799; P78324; Q8N517; Q8TAL8; Q9H0Z2; Q9UDX2; Q9UIJ6; Q9Y4U9" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions" "Prolactin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Male infertility" "7" "0" "1.075" "0.894" "1.085" "1.040" "0.994" "1.035" "1.096" "0.952" "0.782" "205.1" "220.4" "183.3" "222.6" "213.2" "203.9" "212.3" "224.8" "195.3" "160.3" "" "" "" "" "" "" "" "" "" "" "185.1" "170.0" "141.8" "149.9" "177.9" "174.0" "180.1" "162.7" "131.7" "160.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8095037981369694658" "False" "High" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "0.000" "False" "26.145" "25" "3" "8" "3" "150" "17.1" "4.68" "31.82" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of the Early Elongation Complex; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Abortive elongation of HIV-1 transcript in the absence of Tat; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "0.972" "0.973" "1.079" "1.014" "0.992" "1.073" "0.969" "0.955" "1.261" "331.7" "322.5" "322.9" "357.8" "336.2" "329.0" "355.8" "321.4" "316.7" "418.2" "" "" "" "" "" "" "" "" "" "" "299.4" "248.7" "249.7" "240.9" "280.4" "280.8" "301.8" "232.6" "213.6" "418.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9080862626962095597" "False" "High" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "0.000" "False" "26.143" "13" "6" "8" "6" "459" "50.9" "4.73" "26.15" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "0.946" "0.864" "1.071" "0.965" "0.822" "0.989" "0.975" "0.798" "0.801" "321.2" "303.8" "277.6" "344.1" "310.0" "264.0" "317.8" "313.1" "256.4" "257.2" "" "" "" "" "" "" "" "" "" "" "289.9" "234.3" "214.7" "231.7" "258.6" "225.4" "269.6" "226.6" "173.0" "257.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1319936172901890664" "False" "High" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "0.000" "False" "26.116" "20" "4" "5" "4" "191" "22.2" "5.86" "17.00" "4" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6; Factors involved in megakaryocyte development and platelet production" "Effect of progerin on genes involved in progeria; 22q11.2 copy number variation syndrome" "5" "0" "1.087" "1.173" "1.008" "1.126" "1.366" "1.028" "1.052" "1.304" "1.533" "308.8" "335.7" "362.3" "311.4" "347.7" "421.6" "317.4" "324.7" "402.5" "473.2" "" "" "" "" "" "" "" "" "" "" "278.7" "258.9" "280.2" "209.7" "290.0" "359.9" "269.3" "235.0" "271.5" "473.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5055182102876441761" "False" "High" "IsMasterProtein" "Q9BRT9" "DNA replication complex GINS protein SLD5 OS=Homo sapiens OX=9606 GN=GINS4 PE=1 SV=1" "0.000" "False" "26.072" "22" "4" "5" "4" "223" "26.0" "4.98" "21.41" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf05916, Pf16922" "84296" "ENSG00000147536" "GINS4" "B2R8H5; D3DSY0; hsa:84296; Q8N648; Q9BRT9" "Unwinding of DNA" "" "1" "0" "1.121" "1.029" "1.084" "1.094" "1.163" "1.271" "1.163" "1.085" "1.108" "108.1" "121.2" "111.3" "117.2" "118.3" "125.7" "137.4" "125.7" "117.3" "119.8" "" "" "" "" "" "" "" "" "" "" "97.6" "93.5" "86.1" "78.9" "98.7" "107.3" "116.6" "91.0" "79.1" "119.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-204711257539491149" "False" "High" "IsMasterProtein" "O96017" "Serine/threonine-protein kinase Chk2 OS=Homo sapiens OX=9606 GN=CHEK2 PE=1 SV=1" "0.000" "False" "26.058" "11" "5" "7" "5" "543" "60.9" "5.91" "22.89" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00498" "11200" "ENSG00000183765" "CHEK2" "A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5; hsa:11200; O96017; Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; Q6QA11; Q6QA12; Q6QA13; Q9HBS5; Q9HCQ8; Q9UGF0; Q9UGF1" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response" "13" "0" "0.984" "1.102" "1.024" "1.116" "1.037" "1.158" "1.092" "1.124" "0.972" "124.1" "122.2" "136.8" "127.1" "138.6" "128.7" "143.7" "135.5" "139.5" "120.6" "" "" "" "" "" "" "" "" "" "" "112.1" "94.2" "105.8" "85.6" "115.6" "109.9" "121.9" "98.1" "94.1" "120.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242309002880936469" "False" "High" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "0.000" "False" "26.025" "5" "7" "7" "7" "1593" "182.7" "8.44" "19.65" "7" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.173" "1.056" "1.050" "1.088" "0.955" "0.980" "1.044" "1.083" "1.905" "242.8" "284.7" "256.2" "254.9" "264.2" "231.9" "238.0" "253.5" "263.0" "462.5" "" "" "" "" "" "" "" "" "" "" "219.1" "219.6" "198.2" "171.7" "220.4" "198.0" "201.9" "183.5" "177.4" "462.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7237194878275625611" "False" "High" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "0.000" "False" "26.022" "27" "8" "15" "8" "244" "28.1" "6.65" "43.47" "8" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "tRNA processing in the nucleus" "" "1" "0" "0.942" "0.860" "0.857" "0.861" "0.926" "0.864" "0.932" "0.892" "0.937" "1230.3" "1158.6" "1058.4" "1054.2" "1058.7" "1138.9" "1063.1" "1147.1" "1097.8" "1152.5" "" "" "" "" "" "" "" "" "" "" "1110.6" "893.7" "818.6" "709.9" "883.1" "972.1" "901.8" "830.2" "740.4" "1152.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728784246141405942" "False" "High" "IsMasterProtein" "P09543" "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" "0.000" "False" "26.012" "17" "7" "9" "7" "421" "47.5" "9.07" "26.45" "7" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf05881, Pf13671" "1267" "ENSG00000173786" "CNP" "hsa:1267; P09543" "" "Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Cell lineage map for neuronal differentiation" "5" "0" "1.090" "0.933" "1.039" "1.140" "0.911" "1.077" "1.209" "0.970" "1.119" "332.7" "362.7" "310.6" "345.6" "379.3" "303.0" "358.3" "402.2" "322.9" "372.4" "" "" "" "" "" "" "" "" "" "" "300.3" "279.7" "240.2" "232.7" "316.4" "258.6" "303.9" "291.1" "217.8" "372.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064398730154585057" "False" "High" "IsMasterProtein" "Q15061" "WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3" "0.000" "False" "25.971" "7" "5" "7" "5" "677" "74.8" "5.57" "25.06" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04003" "23160" "ENSG00000163811" "WDR43" "hsa:23160; Q15061; Q15395; Q92577" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.059" "1.087" "1.102" "1.145" "0.962" "1.053" "1.085" "1.119" "0.366" "670.4" "709.9" "728.7" "738.7" "767.8" "644.8" "705.6" "727.4" "750.4" "245.7" "" "" "" "" "" "" "" "" "" "" "605.1" "547.6" "563.6" "497.4" "640.5" "550.3" "598.6" "526.4" "506.1" "245.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900163226744829744" "False" "High" "IsMasterProtein" "Q99590" "Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2" "0.000" "False" "25.961" "4" "5" "7" "5" "1463" "164.6" "8.41" "24.36" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf13639" "9169" "ENSG00000139218" "SCAF11" "A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590" "" "Apoptosis" "1" "0" "1.009" "1.104" "1.187" "1.070" "1.109" "1.025" "1.040" "1.242" "0.950" "123.8" "124.8" "136.6" "146.9" "132.4" "137.3" "126.9" "128.8" "153.7" "117.6" "" "" "" "" "" "" "" "" "" "" "111.7" "96.3" "105.7" "98.9" "110.4" "117.2" "107.6" "93.2" "103.7" "117.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6090359432096684388" "False" "High" "IsMasterProtein" "Q8NCN5" "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2" "0.000" "False" "25.939" "6" "6" "6" "6" "879" "99.3" "6.35" "20.18" "6" "" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "55066" "ENSG00000090857" "PDPR" "A7E298; A8K8Y7; B3KSE1; Q6AI20; Q6AWC9; Q8NCN5" "Regulation of pyruvate dehydrogenase (PDH) complex" "" "1" "0" "0.959" "0.951" "0.970" "0.943" "1.078" "0.892" "0.947" "1.087" "0.790" "479.4" "459.8" "455.7" "465.1" "452.1" "516.9" "427.6" "453.7" "521.2" "378.9" "" "" "" "" "" "" "" "" "" "" "432.7" "354.7" "352.4" "313.2" "377.1" "441.2" "362.7" "328.4" "351.6" "378.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9147063981897791280" "False" "High" "IsMasterProtein" "P04632" "Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1" "0.000" "False" "25.902" "14" "3" "7" "3" "268" "28.3" "5.20" "27.79" "3" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "" "826" "ENSG00000126247" "CAPNS1" "A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0" "Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Integrin-mediated cell adhesion" "4" "0" "0.887" "0.945" "1.027" "0.906" "0.868" "0.929" "0.935" "0.775" "0.715" "311.7" "276.6" "294.4" "320.0" "282.3" "270.5" "289.7" "291.5" "241.4" "222.7" "" "" "" "" "" "" "" "" "" "" "281.4" "213.3" "227.7" "215.5" "235.5" "230.9" "245.7" "211.0" "162.8" "222.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876256361286906855" "False" "High" "IsMasterProtein" "P62269" "Small ribosomal subunit protein uS13 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "0.000" "False" "25.869" "34" "6" "20" "6" "152" "17.7" "10.99" "63.99" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.888" "0.952" "0.905" "0.907" "0.988" "0.894" "0.933" "0.895" "0.519" "1495.2" "1327.0" "1423.9" "1352.6" "1356.2" "1477.8" "1336.6" "1395.1" "1337.8" "776.6" "" "" "" "" "" "" "" "" "" "" "1349.7" "1023.6" "1101.3" "910.9" "1131.3" "1261.3" "1133.8" "1009.6" "902.4" "776.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1129418023889810362" "False" "High" "IsMasterProtein" "P40429" "Large ribosomal subunit protein uL13 OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2" "0.000" "False" "25.852" "24" "5" "6" "5" "203" "23.6" "10.93" "21.51" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00572" "23521" "ENSG00000142541" "RPL13A" "A8K505; hsa:23521; P40429" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.948" "1.156" "0.792" "0.959" "0.967" "1.038" "1.056" "1.024" "0.399" "313.8" "297.5" "362.6" "248.7" "300.9" "303.5" "325.7" "331.5" "321.4" "125.2" "" "" "" "" "" "" "" "" "" "" "283.3" "229.4" "280.5" "167.4" "251.0" "259.1" "276.3" "239.9" "216.7" "125.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4208729749156870383" "False" "High" "IsMasterProtein" "O60678" "Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4" "0.000" "False" "25.841" "15" "6" "6" "6" "531" "59.9" "5.35" "16.75" "6" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf06325, Pf21137, Pf21336" "10196" "ENSG00000185238" "PRMT3" "A0A0A0MSN7; B4DUC7; hsa:10196; O60678" "RMTs methylate histone arginines; Protein methylation" "Nitric oxide metabolism in cystic fibrosis" "3" "0" "1.053" "0.968" "1.002" "1.068" "1.026" "1.089" "0.878" "1.046" "0.997" "137.4" "144.7" "132.9" "137.7" "146.7" "140.9" "149.6" "120.7" "143.7" "137.0" "" "" "" "" "" "" "" "" "" "" "124.0" "111.6" "102.8" "92.8" "122.4" "120.3" "126.9" "87.3" "96.9" "137.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-843135532772952093" "False" "High" "IsMasterProtein" "Q8TD55" "Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1" "0.000" "False" "25.811" "8" "4" "5" "4" "490" "53.3" "5.43" "17.55" "4" "other biological processes" "non-structural extracellular;other cell component" "" "Pf00169" "80301" "ENSG00000241839" "PLEKHO2" "hsa:80301; Q7L4H4; Q8TD55; Q8WYS8" "Neutrophil degranulation" "" "1" "0" "1.060" "1.120" "1.086" "1.100" "1.011" "0.998" "1.072" "1.018" "0.971" "248.1" "263.1" "277.9" "269.4" "272.9" "250.8" "247.6" "266.1" "252.6" "240.9" "" "" "" "" "" "" "" "" "" "" "224.0" "202.9" "215.0" "181.4" "227.7" "214.1" "210.0" "192.6" "170.4" "240.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476306151852591039" "False" "High" "IsMasterProtein" "Q15102" "Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1" "0.000" "False" "25.809" "22" "5" "9" "5" "231" "25.7" "6.84" "30.44" "5" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13472" "5050" "ENSG00000079462" "PAFAH1B3" "hsa:5050; Q15102; Q53X88" "COPI-independent Golgi-to-ER retrograde traffic" "PAFAH1B1 copy number variation" "2" "0" "0.978" "0.853" "0.995" "0.835" "0.865" "0.814" "1.020" "0.600" "1.003" "208.5" "203.9" "177.8" "207.5" "174.2" "180.4" "169.7" "212.7" "125.0" "209.1" "" "" "" "" "" "" "" "" "" "" "188.2" "157.3" "137.5" "139.7" "145.3" "153.9" "143.9" "154.0" "84.3" "209.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414945439185658993" "False" "High" "IsMasterProtein" "P84090" "Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1" "0.000" "False" "25.704" "27" "2" "6" "2" "104" "12.3" "5.92" "22.11" "2" "cell cycle OR cell proliferation;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01133" "2079" "ENSG00000100632" "ERH" "B2R5H2; hsa:2079; P70659; P84090; Q14259" "" "" "0" "0" "0.986" "1.283" "0.880" "1.077" "1.348" "0.993" "1.200" "1.270" "0.746" "445.0" "438.8" "571.1" "391.8" "479.1" "599.8" "442.0" "534.2" "564.9" "332.0" "" "" "" "" "" "" "" "" "" "" "401.7" "338.5" "441.7" "263.8" "399.6" "512.0" "374.9" "386.6" "381.0" "332.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3468928122779261644" "False" "High" "IsMasterProtein" "P51398" "Small ribosomal subunit protein mS29 OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "0.000" "False" "25.562" "16" "6" "7" "6" "398" "45.5" "8.88" "17.02" "6" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.968" "0.935" "0.881" "1.002" "0.909" "1.018" "0.970" "0.899" "1.269" "236.5" "228.8" "221.0" "208.3" "236.9" "214.9" "240.9" "229.5" "212.6" "300.2" "" "" "" "" "" "" "" "" "" "" "213.5" "176.5" "171.0" "140.3" "197.6" "183.4" "204.3" "166.1" "143.4" "300.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5022575274388480768" "False" "High" "IsMasterProtein" "P28161" "Glutathione S-transferase Mu 2 OS=Homo sapiens OX=9606 GN=GSTM2 PE=1 SV=2" "0.000" "False" "25.557" "28" "6" "9" "3" "218" "25.7" "6.37" "25.48" "6" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00043, Pf02798" "2946" "ENSG00000213366" "GSTM2" "B4DRY4; E9PEM9; hsa:2946; P28161; Q2M318; Q5TZY5; Q8WWE1" "Glutathione conjugation" "Glutathione metabolism; Nuclear receptors meta-pathway; NRF2 pathway; FOXA2 pathway; Metapathway biotransformation Phase I and II" "6" "0" "1.040" "1.020" "0.977" "0.879" "0.802" "0.930" "0.922" "0.994" "0.783" "92.4" "96.1" "94.3" "90.3" "81.3" "74.2" "86.0" "85.2" "91.9" "72.4" "" "" "" "" "" "" "" "" "" "" "83.4" "74.1" "72.9" "60.8" "67.8" "63.3" "72.9" "61.7" "62.0" "72.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2531564844693564972" "False" "High" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "0.000" "False" "25.538" "12" "7" "10" "6" "530" "60.1" "9.13" "26.70" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "Formation of WDR5-containing histone-modifying complexes; Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "MECP2 and associated Rett syndrome" "8" "0" "1.077" "0.973" "0.817" "1.061" "0.960" "0.981" "0.981" "0.979" "0.929" "309.9" "333.7" "301.5" "253.1" "328.8" "297.6" "303.9" "304.0" "303.5" "288.0" "" "" "" "" "" "" "" "" "" "" "279.8" "257.4" "233.2" "170.4" "274.2" "254.0" "257.8" "220.0" "204.7" "288.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524460011519656721" "False" "High" "IsMasterProtein" "P50749" "Ras association domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RASSF2 PE=1 SV=1" "0.000" "False" "25.516" "17" "5" "6" "5" "326" "37.8" "8.84" "20.87" "5" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity" "Pf00788, Pf16517" "9770" "ENSG00000101265" "RASSF2" "A6NIX9; A8K5Z3; hsa:9770; P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5" "" "Pleural mesothelioma" "1" "0" "1.033" "0.867" "0.985" "1.123" "0.936" "1.055" "0.377" "0.876" "9.073" "117.8" "121.6" "102.1" "116.0" "132.3" "110.2" "124.2" "44.4" "103.2" "1068.4" "" "" "" "" "" "" "" "" "" "" "106.3" "93.8" "78.9" "78.1" "110.3" "94.1" "105.4" "32.1" "69.6" "1068.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232907791819213920" "False" "High" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "0.000" "False" "25.483" "16" "3" "5" "3" "205" "22.9" "4.63" "19.23" "3" "" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "Neutrophil degranulation" "" "1" "0" "0.999" "0.977" "0.834" "0.973" "1.105" "0.864" "1.013" "1.100" "0.799" "365.4" "365.0" "357.0" "304.9" "355.5" "403.9" "315.6" "370.4" "402.0" "291.8" "" "" "" "" "" "" "" "" "" "" "329.9" "281.6" "276.1" "205.3" "296.6" "344.7" "267.8" "268.0" "271.2" "291.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5394846730023349610" "False" "High" "IsMasterProtein" "P55081" "Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2" "0.000" "False" "25.431" "15" "5" "6" "5" "439" "51.9" "4.98" "16.92" "5" "RNA metabolism OR transcription;other metabolic processes" "extracellular matrix;cytoskeleton;nucleus" "" "Pf06991" "4236" "ENSG00000140259" "MFAP1" "hsa:4236; P55081; Q86TG6" "mRNA Splicing - Major Pathway" "Canonical and non-canonical Notch signaling; Ciliary landscape" "3" "0" "1.049" "1.136" "1.170" "0.995" "1.046" "1.081" "1.091" "1.079" "0.398" "484.8" "508.8" "550.8" "567.3" "482.3" "507.1" "524.2" "529.1" "523.2" "192.8" "" "" "" "" "" "" "" "" "" "" "437.7" "392.4" "426.0" "382.0" "402.3" "432.8" "444.7" "382.9" "352.9" "192.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4335544546222164902" "False" "High" "IsMasterProtein" "Q9NRX4" "14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1" "0.000" "False" "25.418" "42" "5" "9" "5" "125" "13.8" "6.07" "27.27" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05005" "29085" "ENSG00000054148" "PHPT1" "B1AMX0; B1AMX1; hsa:29085; Q9H0Y3; Q9NRX4" "" "" "0" "0" "1.056" "1.050" "1.017" "1.018" "1.054" "1.029" "1.115" "1.010" "0.758" "749.5" "791.5" "787.0" "762.2" "763.0" "790.0" "771.3" "836.0" "757.2" "567.8" "" "" "" "" "" "" "" "" "" "" "676.6" "610.5" "608.7" "513.3" "636.5" "674.3" "654.3" "605.0" "510.7" "567.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7563735417890983721" "False" "High" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "0.000" "False" "25.411" "28" "4" "8" "4" "172" "19.7" "5.00" "22.98" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400; ENSG00000292191" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Recruitment of NuMA to mitotic centrosomes; SUMOylation of DNA damage response and repair proteins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "13" "0" "1.015" "1.047" "0.990" "0.938" "0.958" "0.964" "1.024" "1.008" "1.172" "303.0" "307.6" "317.2" "300.1" "284.3" "290.4" "292.1" "310.3" "305.6" "355.2" "" "" "" "" "" "" "" "" "" "" "273.6" "237.2" "245.3" "202.1" "237.1" "247.9" "247.8" "224.6" "206.1" "355.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4682343242687865588" "False" "High" "IsMasterProtein" "O43818" "U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1" "0.000" "False" "25.375" "13" "7" "12" "7" "475" "51.8" "7.85" "40.44" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400" "9136" "ENSG00000114767" "RRP9" "B2R996; hsa:9136; O43818; Q8IZ30" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.059" "1.142" "0.988" "1.062" "1.229" "0.986" "1.002" "1.132" "0.737" "991.4" "1049.6" "1132.5" "979.5" "1052.9" "1218.0" "977.3" "993.6" "1122.2" "730.8" "" "" "" "" "" "" "" "" "" "" "895.0" "809.6" "875.9" "659.6" "878.3" "1039.6" "829.0" "719.1" "756.9" "730.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174147483962909046" "False" "High" "IsMasterProtein" "Q9NRX1" "RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1" "0.000" "False" "25.337" "16" "4" "5" "4" "252" "27.9" "9.73" "17.09" "4" "other biological processes" "cytosol;nucleus;other cell component" "" "" "56902" "ENSG00000115946" "PNO1" "A8K6Q0; hsa:56902; Q53G13; Q8WVB8; Q9NRX1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.060" "0.939" "1.015" "0.972" "0.879" "0.926" "0.929" "0.848" "1.413" "322.9" "342.2" "303.2" "327.7" "313.9" "283.7" "299.0" "299.9" "273.7" "456.4" "" "" "" "" "" "" "" "" "" "" "291.5" "264.0" "234.5" "220.7" "261.8" "242.1" "253.6" "217.0" "184.6" "456.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428809261446700766" "False" "High" "IsMasterProtein" "Q9UNN5" "FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2" "0.000" "False" "25.334" "10" "8" "11" "8" "650" "73.9" "4.88" "35.05" "8" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "11124" "ENSG00000185104" "FAF1" "hsa:11124; Q549F0; Q9UF34; Q9UNN5; Q9UNT3; Q9Y2Z3" "" "Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; VEGFA-VEGFR2 signaling" "3" "0" "1.088" "0.916" "1.124" "1.090" "1.000" "0.938" "0.962" "1.015" "0.851" "381.8" "415.4" "349.8" "429.2" "416.1" "381.9" "358.3" "367.3" "387.4" "324.8" "" "" "" "" "" "" "" "" "" "" "344.6" "320.4" "270.5" "289.0" "347.1" "325.9" "303.9" "265.8" "261.3" "324.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4076214252454433299" "False" "High" "IsMasterProtein" "Q969G3" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2" "0.000" "False" "25.331" "11" "4" "7" "4" "411" "46.6" "4.88" "22.83" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6605" "ENSG00000073584" "SMARCE1" "B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6; hsa:6605; O43539; Q969G3" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis" "6" "0" "0.971" "1.040" "1.124" "0.966" "1.017" "1.033" "0.799" "1.114" "3.421" "233.2" "226.4" "242.4" "262.0" "225.2" "237.2" "241.0" "186.4" "259.8" "797.9" "" "" "" "" "" "" "" "" "" "" "210.5" "174.6" "187.5" "176.4" "187.9" "202.4" "204.4" "134.9" "175.2" "797.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4683582367495080514" "False" "High" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "0.000" "False" "25.309" "7" "5" "7" "5" "826" "92.4" "5.96" "21.85" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "HATs acetylate histones" "" "1" "0" "0.943" "0.965" "1.014" "1.020" "0.851" "1.030" "0.929" "0.908" "1.190" "131.7" "124.2" "127.1" "133.6" "134.3" "112.1" "135.6" "122.4" "119.6" "156.7" "" "" "" "" "" "" "" "" "" "" "118.9" "95.8" "98.3" "90.0" "112.0" "95.6" "115.1" "88.6" "80.7" "156.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9069432479560653681" "False" "High" "IsMasterProtein" "Q08AM6" "Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1" "0.000" "False" "25.300" "8" "7" "9" "7" "782" "87.9" "6.13" "33.87" "7" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11916, Pf12755" "55697" "ENSG00000103043" "VAC14" "B3KPJ5; B3KSM8; hsa:55697; Q08AM6; Q13174; Q6IA12; Q7L4Y1; Q9BW96; Q9H6V6" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "0.995" "0.835" "0.990" "1.003" "0.833" "0.974" "1.012" "0.883" "0.797" "759.5" "755.5" "634.2" "751.8" "761.7" "632.8" "739.6" "768.7" "670.7" "605.5" "" "" "" "" "" "" "" "" "" "" "685.6" "582.7" "490.5" "506.2" "635.4" "540.1" "627.4" "556.3" "452.4" "605.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779852501093026521" "False" "High" "IsMasterProtein" "P15153" "Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1" "0.000" "False" "25.293" "20" "4" "10" "3" "192" "21.4" "7.61" "33.56" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5880" "ENSG00000128340" "RAC2" "hsa:5880; P15153; Q9UDJ4" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; PCP/CE pathway; ROS and RNS production in phagocytes; RHO GTPases Activate NADPH Oxidases" "Integrin-mediated cell adhesion; RalA downstream regulated genes; B cell receptor signaling pathway; Focal adhesion; MAPK signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Macrophage markers; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Insulin signaling; Regulation of actin cytoskeleton; Pathways in cancer; DNA damage response (only ATM dependent)" "24" "0" "1.086" "0.854" "1.127" "0.996" "0.884" "0.990" "0.974" "0.883" "0.786" "694.3" "754.1" "593.1" "782.7" "691.8" "613.5" "687.5" "676.0" "613.4" "545.6" "" "" "" "" "" "" "" "" "" "" "626.7" "581.7" "458.7" "527.1" "577.1" "523.7" "583.2" "489.2" "413.7" "545.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3124234521907955571" "False" "High" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "0.000" "False" "25.288" "30" "3" "4" "3" "153" "17.2" "8.22" "17.54" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "0.982" "1.049" "0.945" "1.062" "0.955" "0.974" "0.863" "0.966" "1.103" "285.5" "280.5" "299.6" "269.7" "303.1" "272.7" "278.2" "246.3" "275.9" "314.9" "" "" "" "" "" "" "" "" "" "" "257.7" "216.4" "231.7" "181.6" "252.8" "232.8" "236.0" "178.2" "186.1" "314.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2304396321486536577" "False" "High" "IsMasterProtein" "Q8IXQ4" "GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1" "0.000" "False" "25.285" "13" "4" "5" "4" "340" "38.1" "5.41" "18.30" "4" "" "" "" "Pf12572" "55425" "ENSG00000133114" "GPALPP1" "A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6" "" "" "0" "0" "0.909" "1.008" "1.085" "0.983" "1.075" "0.849" "1.001" "1.091" "0.779" "102.3" "93.0" "103.1" "111.1" "100.6" "110.0" "86.9" "102.4" "111.6" "79.7" "" "" "" "" "" "" "" "" "" "" "92.4" "71.8" "79.8" "74.8" "83.9" "93.9" "73.7" "74.1" "75.3" "79.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819373703684901703" "False" "High" "IsMasterProtein" "Q2KHT3" "Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2" "0.000" "False" "25.267" "6" "7" "8" "7" "1053" "117.6" "5.86" "24.55" "7" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf09758, Pf19439" "23274" "ENSG00000038532" "CLEC16A" "hsa:23274; O15058; Q2KHT3; Q6ZTB2" "" "Vitamin D receptor pathway" "1" "0" "0.964" "0.967" "1.047" "0.999" "0.959" "1.033" "1.102" "0.969" "0.816" "442.7" "426.7" "428.1" "463.4" "442.3" "424.3" "457.4" "487.9" "429.1" "361.1" "" "" "" "" "" "" "" "" "" "" "399.6" "329.1" "331.1" "312.1" "368.9" "362.2" "388.0" "353.1" "289.4" "361.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4839945324263831738" "False" "High" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "0.000" "False" "25.245" "20" "6" "6" "6" "307" "33.7" "8.21" "18.36" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "" "Fatty acid biosynthesis" "1" "0" "0.934" "0.992" "0.965" "0.935" "1.030" "0.949" "0.891" "1.042" "0.652" "379.7" "354.7" "376.6" "366.5" "354.9" "390.9" "360.5" "338.4" "395.8" "247.6" "" "" "" "" "" "" "" "" "" "" "342.7" "273.6" "291.3" "246.8" "296.1" "333.7" "305.8" "244.9" "266.9" "247.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-366099160936262297" "False" "High" "IsMasterProtein" "Q9NQG5" "Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1" "0.000" "False" "25.209" "12" "3" "5" "3" "326" "36.9" "5.97" "21.81" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "58490" "ENSG00000101413" "RPRD1B" "hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5" "RNA polymerase II transcribes snRNA genes" "Modulators of TCR signaling and T cell activation" "2" "0" "0.919" "0.852" "0.975" "0.939" "0.834" "1.029" "0.935" "0.828" "1.065" "392.6" "360.9" "334.4" "383.0" "368.5" "327.3" "404.2" "367.0" "325.2" "418.1" "" "" "" "" "" "" "" "" "" "" "354.4" "278.3" "258.7" "257.9" "307.4" "279.4" "342.8" "265.6" "219.4" "418.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6020211284576112703" "False" "High" "IsMasterProtein" "Q86UY8" "5'-nucleotidase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NT5DC3 PE=1 SV=1" "0.000" "False" "25.204" "13" "8" "10" "8" "548" "63.4" "8.31" "23.76" "8" "" "cytosol;other cell component" "other molecular function" "Pf05761" "51559" "ENSG00000111696" "NT5DC3" "hsa:51559; Q86UY8; Q9NUM7; Q9P2T2; Q9P2T3" "" "" "0" "0" "1.047" "1.220" "1.030" "0.936" "1.167" "1.033" "1.004" "1.112" "0.752" "278.1" "291.3" "339.4" "286.6" "260.4" "324.5" "287.3" "279.3" "309.2" "209.1" "" "" "" "" "" "" "" "" "" "" "251.0" "224.7" "262.5" "193.0" "217.2" "277.0" "243.7" "202.1" "208.6" "209.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3715797868298302435" "False" "High" "IsMasterProtein" "Q5ST30" "Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2" "0.000" "False" "25.202" "6" "6" "8" "6" "1063" "118.4" "7.02" "24.88" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00133, Pf08264" "57176" "ENSG00000137411; ENSG00000223494" "VARS2" "A2ABL7; B4DET4; B4E3P5; F5GXJ0; F5H323; hsa:57176; Q2M2A0; Q59FI1; Q5SQ96; Q5SS98; Q5ST30; Q6DKJ5; Q6ZV24; Q96GN2; Q96H77; Q96Q02; Q9H6R2; Q9UFH7" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.039" "0.911" "1.121" "1.037" "0.969" "1.063" "1.083" "1.013" "0.894" "456.7" "474.5" "416.0" "512.0" "473.4" "442.5" "485.6" "494.4" "462.7" "408.2" "" "" "" "" "" "" "" "" "" "" "412.2" "366.0" "321.7" "344.8" "394.9" "377.6" "411.9" "357.8" "312.1" "408.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864018122010782004" "False" "High" "IsMasterProtein" "P35080" "Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3" "0.000" "False" "25.193" "27" "3" "7" "3" "140" "15.0" "6.99" "17.25" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5217" "ENSG00000070087" "PFN2" "B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2" "RHO GTPases Activate Formins; Signaling by ROBO receptors" "Physico-chemical features and toxicity-associated pathways" "3" "0" "1.070" "0.946" "0.848" "1.158" "1.332" "0.991" "0.919" "1.198" "1.094" "160.0" "171.2" "151.4" "135.6" "185.3" "213.1" "158.5" "147.0" "191.7" "175.1" "" "" "" "" "" "" "" "" "" "" "144.4" "132.1" "117.1" "91.3" "154.6" "181.9" "134.4" "106.4" "129.3" "175.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7950271419257628424" "False" "High" "IsMasterProtein" "P30049" "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" "0.000" "False" "25.185" "14" "2" "6" "2" "168" "17.5" "5.49" "22.72" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf02823, Pf21335" "513" "ENSG00000099624" "ATP5F1D" "D6W5Y3; hsa:513; P30049; Q6FG90" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "5" "0" "1.049" "1.176" "1.110" "1.051" "1.190" "1.048" "1.088" "1.179" "0.635" "443.8" "465.4" "521.9" "492.7" "466.2" "528.2" "465.0" "482.7" "523.0" "281.9" "" "" "" "" "" "" "" "" "" "" "400.6" "359.0" "403.6" "331.8" "388.9" "450.8" "394.4" "349.3" "352.7" "281.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-572232975925861742" "False" "High" "IsMasterProtein" "P46779" "Large ribosomal subunit protein eL28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "0.000" "False" "25.157" "38" "6" "8" "6" "137" "15.7" "12.02" "26.96" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "0.863" "1.236" "1.183" "1.005" "1.152" "1.160" "1.120" "1.228" "0.372" "1111.6" "959.3" "1373.4" "1314.7" "1116.9" "1280.5" "1289.1" "1245.5" "1365.1" "413.8" "" "" "" "" "" "" "" "" "" "" "1003.4" "740.0" "1062.2" "885.3" "931.7" "1092.9" "1093.6" "901.3" "920.7" "413.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6380773280211833227" "False" "High" "IsMasterProtein" "Q9Y508" "E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1" "0.000" "False" "25.140" "30" "4" "5" "4" "228" "25.7" "7.25" "18.92" "4" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf05605, Pf13445, Pf18574" "55905" "ENSG00000124226" "RNF114" "B2RDQ9; B4DWY5; E1P627; hsa:55905; Q6N0B0; Q9Y508" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.006" "1.021" "1.072" "1.094" "0.980" "1.119" "1.010" "0.904" "0.941" "105.7" "106.3" "107.9" "113.3" "115.6" "103.6" "118.2" "106.7" "95.5" "99.4" "" "" "" "" "" "" "" "" "" "" "95.4" "82.0" "83.4" "76.3" "96.4" "88.4" "100.3" "77.2" "64.4" "99.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4672476971480337418" "False" "High" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "0.000" "False" "25.117" "23" "4" "9" "4" "215" "24.9" "5.55" "35.31" "4" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Condensation of Prometaphase Chromosomes; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Regulation of PTEN stability and activity; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "21" "0" "1.011" "1.012" "0.963" "1.065" "1.144" "0.991" "1.056" "1.077" "1.136" "373.3" "377.4" "377.7" "359.4" "397.5" "427.2" "370.0" "394.2" "401.9" "424.0" "" "" "" "" "" "" "" "" "" "" "337.0" "291.1" "292.1" "242.0" "331.5" "364.6" "313.9" "285.3" "271.1" "424.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1699375806796057255" "False" "High" "IsMasterProtein" "Q6IA69" "Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3" "0.000" "False" "25.106" "7" "4" "8" "4" "706" "79.2" "6.44" "20.16" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00795, Pf02540" "55191" "ENSG00000172890" "NADSYN1" "B3KUU4; hsa:55191; Q6IA69; Q86SN2; Q9HA25; Q9NVM8" "Nicotinate metabolism" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways" "3" "0" "1.023" "1.004" "0.959" "1.001" "0.943" "1.011" "1.123" "0.948" "0.676" "339.4" "347.3" "340.8" "325.4" "339.7" "320.0" "343.3" "381.2" "321.7" "229.5" "" "" "" "" "" "" "" "" "" "" "306.4" "267.9" "263.6" "219.1" "283.4" "273.2" "291.2" "275.8" "217.0" "229.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8650406954565681421" "False" "High" "IsMasterProtein" "P48426" "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2" "0.000" "False" "25.102" "17" "6" "9" "3" "406" "46.2" "6.99" "28.53" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "5305" "ENSG00000150867" "PIP4K2A" "B0YJ66; B4DGX2; D3DRV1; hsa:5305; P48426; P53807; Q5VUX3" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton; G13 signaling pathway" "6" "2" "0.991" "0.955" "1.029" "0.944" "0.925" "0.936" "1.005" "1.002" "0.965" "760.3" "753.4" "726.4" "782.7" "717.8" "703.3" "711.8" "763.8" "762.2" "733.6" "" "" "" "" "" "" "" "" "" "" "686.3" "581.1" "561.8" "527.1" "598.8" "600.3" "603.8" "552.8" "514.1" "733.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9037349892504840241" "False" "High" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "0.000" "False" "25.088" "22" "7" "10" "7" "312" "35.1" "6.13" "30.61" "7" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "O00764; Q7Z2Y0; Q9BS02" "Neutrophil degranulation; Vitamin B6 activation to pyridoxal phosphate" "" "2" "0" "0.940" "1.025" "1.037" "0.979" "0.967" "0.999" "0.975" "1.099" "0.808" "495.7" "466.2" "508.3" "514.0" "485.3" "479.2" "495.5" "483.5" "544.7" "400.4" "" "" "" "" "" "" "" "" "" "" "447.5" "359.6" "393.2" "346.1" "404.8" "409.0" "420.3" "349.9" "367.4" "400.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6259860464076082435" "False" "High" "IsMasterProtein" "Q9NR31" "Small COPII coat GTPase SAR1A OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1" "0.000" "False" "25.072" "20" "4" "9" "2" "198" "22.4" "6.68" "27.14" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00025" "56681" "ENSG00000079332" "SAR1A" "B4DQ19; hsa:56681; Q9NR31" "" "Sterol regulatory element-binding proteins (SREBP) signaling" "1" "1" "0.787" "0.851" "0.822" "0.866" "0.753" "0.849" "0.949" "0.867" "0.702" "617.4" "485.8" "525.1" "507.5" "534.7" "465.2" "524.1" "585.7" "535.3" "433.1" "" "" "" "" "" "" "" "" "" "" "557.3" "374.7" "406.1" "341.7" "446.0" "397.0" "444.6" "423.9" "361.0" "433.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8633785530779633839" "False" "High" "IsMasterProtein" "P49354" "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1" "0.000" "False" "25.062" "13" "5" "6" "5" "379" "44.4" "5.08" "18.32" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01239" "2339" "ENSG00000168522" "FNTA" "A6NJW0; hsa:2339; P49354; Q53XJ9; Q9UDC1" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing; Apoptotic cleavage of cellular proteins" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "9" "0" "0.883" "0.885" "0.881" "0.991" "1.002" "0.916" "1.065" "1.071" "0.785" "170.9" "150.9" "151.3" "150.5" "169.4" "171.2" "156.5" "182.1" "183.0" "134.2" "" "" "" "" "" "" "" "" "" "" "154.3" "116.4" "117.0" "101.3" "141.3" "146.1" "132.7" "131.8" "123.4" "134.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2886709730536475345" "False" "High" "IsMasterProtein" "Q9BTT0" "Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1" "0.000" "False" "25.015" "10" "2" "9" "2" "268" "30.7" "3.85" "24.33" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14580" "81611" "ENSG00000143401" "ANP32E" "B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0" "" "" "0" "0" "1.062" "0.938" "1.082" "0.983" "1.158" "1.109" "0.599" "1.002" "6.632" "65.2" "69.2" "61.2" "70.6" "64.1" "75.5" "72.3" "39.1" "65.3" "432.4" "" "" "" "" "" "" "" "" "" "" "58.9" "53.4" "47.3" "47.5" "53.5" "64.5" "61.4" "28.3" "44.1" "432.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4621514541592481866" "False" "High" "IsMasterProtein" "O75376" "Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2" "0.000" "False" "24.992" "3" "7" "8" "6" "2440" "270.0" "7.11" "19.15" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9611" "ENSG00000141027" "NCOR1" "B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18" "HDACs deacetylate histones; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome; 22q11.2 copy number variation syndrome; Notch signaling pathway" "30" "0" "1.017" "0.948" "1.122" "1.040" "1.099" "1.191" "1.038" "1.100" "1.345" "79.7" "81.0" "75.5" "89.4" "82.8" "87.6" "94.9" "82.7" "87.6" "107.1" "" "" "" "" "" "" "" "" "" "" "71.9" "62.5" "58.4" "60.2" "69.1" "74.7" "80.5" "59.9" "59.1" "107.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9188891296985920952" "False" "High" "IsMasterProtein" "P31483" "Cytotoxic granule associated RNA binding protein TIA1 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "0.000" "False" "24.976" "11" "4" "9" "2" "386" "42.9" "7.74" "30.13" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "FGFR2 alternative splicing" "" "1" "2" "0.982" "1.182" "0.882" "1.071" "1.155" "0.986" "1.064" "1.051" "0.967" "314.8" "309.1" "372.0" "277.5" "337.2" "363.7" "310.4" "335.0" "330.9" "304.5" "" "" "" "" "" "" "" "" "" "" "284.1" "238.4" "287.7" "186.9" "281.3" "310.4" "263.3" "242.4" "223.2" "304.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369435830510499583" "False" "High" "IsMasterProtein" "Q9GZP4" "PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1" "0.000" "False" "24.965" "30" "6" "7" "6" "211" "24.2" "5.74" "20.71" "6" "other biological processes" "other cell component" "" "Pf06201" "57095" "ENSG00000057757" "PITHD1" "B2R7J4; hsa:57095; Q5QPN6; Q5QPN7; Q9GZP4; Q9NRI8" "" "" "0" "0" "0.904" "1.033" "0.922" "0.898" "1.008" "0.946" "1.044" "0.986" "0.671" "708.4" "640.6" "731.5" "653.0" "636.1" "713.9" "670.4" "739.8" "698.8" "475.1" "" "" "" "" "" "" "" "" "" "" "639.5" "494.1" "565.8" "439.7" "530.6" "609.3" "568.7" "535.4" "471.3" "475.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4528933939237155494" "False" "High" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "0.000" "False" "24.956" "12" "4" "4" "4" "414" "44.7" "6.25" "17.45" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "8" "0" "1.086" "0.953" "1.146" "1.058" "0.914" "1.129" "1.039" "0.961" "2.584" "362.6" "393.9" "345.4" "415.4" "383.6" "331.4" "409.2" "376.7" "348.6" "937.0" "" "" "" "" "" "" "" "" "" "" "327.3" "303.9" "267.2" "279.8" "320.0" "282.9" "347.1" "272.6" "235.1" "937.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7112262159952005485" "False" "High" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "0.000" "False" "24.948" "18" "5" "6" "5" "356" "38.1" "9.83" "19.96" "5" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "1.003" "1.026" "1.040" "0.982" "1.069" "1.000" "1.031" "1.108" "0.825" "328.7" "329.7" "337.2" "341.9" "322.8" "351.5" "328.7" "338.8" "364.1" "271.1" "" "" "" "" "" "" "" "" "" "" "296.7" "254.3" "260.8" "230.2" "269.3" "300.0" "278.8" "245.2" "245.6" "271.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "385044699666679526" "False" "High" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "0.000" "False" "24.940" "6" "4" "4" "4" "843" "100.1" "6.32" "15.20" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "mRNA Splicing - Major Pathway" "" "1" "0" "0.949" "0.900" "1.056" "0.987" "0.967" "0.962" "0.900" "0.944" "2.405" "255.7" "242.8" "230.1" "270.1" "252.3" "247.3" "245.9" "230.2" "241.4" "615.0" "" "" "" "" "" "" "" "" "" "" "230.8" "187.2" "177.9" "181.9" "210.5" "211.1" "208.6" "166.6" "162.8" "615.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2714329419910624829" "False" "High" "IsMasterProtein" "P47985" "Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2" "0.000" "False" "24.934" "18" "5" "6" "5" "274" "29.6" "8.32" "21.57" "5" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "7386" "ENSG00000169021" "UQCRFS1" "A8K519; hsa:7386; P47985; Q6NVX5; Q9UPH2" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; Iron metabolism disorders; Arsenic metabolism and reactive oxygen species generation" "6" "0" "1.052" "1.063" "1.033" "1.087" "0.954" "1.050" "1.016" "1.079" "1.254" "379.2" "398.9" "402.9" "391.6" "412.3" "361.6" "398.1" "385.2" "409.1" "475.5" "" "" "" "" "" "" "" "" "" "" "342.3" "307.7" "311.6" "263.7" "343.9" "308.6" "337.7" "278.8" "276.0" "475.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8446655200423982377" "False" "High" "IsMasterProtein" "Q8N4C8" "Misshapen-like kinase 1 OS=Homo sapiens OX=9606 GN=MINK1 PE=1 SV=2" "0.000" "False" "24.911" "5" "5" "6" "2" "1332" "149.7" "7.85" "16.49" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "50488" "ENSG00000141503" "MINK1" "D3DTK3; D3DTK4; hsa:50488; Q5U8Z0; Q8N4C8; Q9P1X1; Q9P2R8" "Oxidative Stress Induced Senescence" "Angiopoietin-like protein 8 regulatory pathway; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "5" "0" "1.048" "0.921" "1.096" "1.047" "0.959" "1.042" "1.039" "0.981" "0.995" "107.9" "113.1" "99.4" "118.3" "113.0" "103.5" "112.5" "112.1" "105.9" "107.4" "" "" "" "" "" "" "" "" "" "" "97.4" "87.2" "76.9" "79.7" "94.3" "88.3" "95.4" "81.1" "71.4" "107.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208446995115017732" "False" "High" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "0.000" "False" "24.905" "18" "7" "9" "7" "455" "51.8" "6.35" "20.45" "7" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "0.948" "1.172" "0.794" "0.777" "1.084" "0.781" "0.996" "0.863" "0.676" "703.0" "666.3" "824.1" "557.9" "546.2" "762.1" "549.1" "700.0" "606.6" "475.1" "" "" "" "" "" "" "" "" "" "" "634.5" "513.9" "637.4" "375.7" "455.6" "650.4" "465.8" "506.6" "409.1" "475.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841386405994122390" "False" "High" "IsMasterProtein" "Q92785" "Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2" "0.000" "False" "24.903" "12" "4" "8" "4" "391" "44.1" "6.33" "20.33" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "5977" "ENSG00000133884" "DPF2" "A8K7C9; B4DT58; hsa:5977; Q92785" "" "Tumor suppressor activity of SMARCB1" "1" "0" "1.231" "1.529" "0.934" "1.115" "1.355" "1.015" "1.087" "1.414" "2.184" "188.1" "231.6" "287.6" "175.6" "209.9" "254.9" "191.0" "204.6" "266.0" "410.9" "" "" "" "" "" "" "" "" "" "" "169.8" "178.7" "222.5" "118.3" "175.1" "217.6" "162.0" "148.1" "179.4" "410.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3988284594388072596" "False" "High" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "0.000" "False" "24.886" "9" "10" "10" "10" "986" "111.5" "7.27" "27.79" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOA GTPase cycle; RHOB GTPase cycle" "Pathogenic Escherichia coli infection" "5" "0" "0.966" "0.999" "1.170" "1.071" "0.989" "1.057" "0.863" "0.988" "3.846" "202.4" "195.5" "202.1" "236.9" "216.8" "200.1" "214.0" "174.7" "199.9" "778.5" "" "" "" "" "" "" "" "" "" "" "182.7" "150.8" "156.3" "159.5" "180.8" "170.8" "181.5" "126.4" "134.8" "778.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6008736440558391918" "False" "High" "IsMasterProtein" "O75157" "TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3" "0.000" "False" "24.879" "6" "4" "5" "4" "780" "79.2" "5.02" "21.36" "4" "stress response;other biological processes" "" "" "Pf01166" "9819" "ENSG00000196428" "TSC22D2" "D3DNI5; hsa:9819; O75157; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8" "" "" "0" "0" "1.015" "0.844" "1.154" "1.030" "0.902" "0.988" "1.007" "0.968" "0.787" "189.2" "192.0" "159.8" "218.4" "194.8" "170.6" "186.9" "190.6" "183.2" "148.9" "" "" "" "" "" "" "" "" "" "" "170.8" "148.1" "123.6" "147.1" "162.5" "145.7" "158.6" "137.9" "123.6" "148.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369433181564394735" "False" "High" "IsMasterProtein" "P08708" "Small ribosomal subunit protein eS17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "0.000" "False" "24.852" "37" "4" "9" "4" "135" "15.5" "9.85" "28.33" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.866" "1.031" "1.011" "1.002" "0.969" "0.964" "1.040" "1.038" "0.761" "360.1" "311.8" "371.1" "364.1" "360.9" "349.0" "347.2" "374.6" "373.7" "274.0" "" "" "" "" "" "" "" "" "" "" "325.0" "240.5" "287.0" "245.2" "301.1" "297.8" "294.5" "271.1" "252.0" "274.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625862126903742140" "False" "High" "IsMasterProtein" "P48556" "26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2" "0.000" "False" "24.843" "16" "7" "11" "7" "350" "39.6" "9.70" "32.31" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf10075" "5714" "ENSG00000099341" "PSMD8" "B4DX18; hsa:5714; P48556; Q6P1L7" "Regulation of PTEN stability and activity; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "64" "0" "0.923" "0.692" "0.857" "0.952" "0.753" "0.964" "0.864" "0.778" "0.749" "635.9" "586.6" "439.8" "544.7" "605.3" "478.6" "613.0" "549.3" "494.8" "476.3" "" "" "" "" "" "" "" "" "" "" "574.0" "452.5" "340.2" "366.8" "504.9" "408.5" "520.0" "397.5" "333.7" "476.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4146618986531713622" "False" "High" "IsMasterProtein" "P46782" "Small ribosomal subunit protein uS7 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "0.000" "False" "24.804" "24" "5" "10" "5" "204" "22.9" "9.72" "30.37" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.993" "0.976" "0.947" "1.040" "1.153" "0.966" "1.064" "1.030" "0.654" "678.6" "673.5" "662.4" "642.6" "705.7" "782.5" "655.6" "722.0" "699.1" "443.9" "" "" "" "" "" "" "" "" "" "" "612.5" "519.5" "512.4" "432.7" "588.7" "667.8" "556.1" "522.5" "471.5" "443.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3263618484320997085" "False" "High" "IsMasterProtein" "Q9H098" "Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1" "0.000" "False" "24.781" "31" "4" "8" "4" "131" "15.5" "8.29" "24.36" "4" "" "" "" "Pf06625" "83641" "ENSG00000065809" "FAM107B" "A8K1P4; D3DRT2; hsa:83641; Q5T9K7; Q5T9K8; Q6ZSI4; Q9H098" "" "" "0" "0" "1.064" "1.084" "0.951" "0.871" "1.050" "1.035" "1.085" "1.091" "0.678" "477.0" "507.7" "517.1" "453.6" "415.6" "501.0" "493.5" "517.6" "520.5" "323.6" "" "" "" "" "" "" "" "" "" "" "430.6" "391.6" "399.9" "305.5" "346.7" "427.6" "418.6" "374.6" "351.1" "323.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9193624318579361527" "False" "High" "IsMasterProtein" "Q9UGI8" "Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1" "0.000" "False" "24.724" "14" "6" "10" "6" "421" "48.0" "7.68" "29.49" "6" "other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412, Pf06297" "26136" "ENSG00000135269" "TES" "A4D0U6; hsa:26136; Q9GZQ1; Q9HAJ9; Q9UGI8" "" "" "0" "0" "1.023" "0.930" "0.956" "0.994" "0.956" "0.971" "0.994" "0.964" "0.766" "666.8" "682.0" "620.0" "637.5" "662.5" "637.4" "647.7" "662.7" "642.6" "510.4" "" "" "" "" "" "" "" "" "" "" "601.9" "526.1" "479.5" "429.3" "552.6" "544.1" "549.4" "479.6" "433.4" "510.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7722178459817833286" "False" "High" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "0.000" "False" "24.703" "17" "2" "8" "2" "127" "14.5" "5.38" "21.69" "2" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "0" "1.067" "0.953" "1.065" "1.043" "1.066" "1.079" "1.064" "1.040" "0.736" "256.5" "273.6" "244.6" "273.1" "267.7" "273.5" "276.7" "273.0" "266.9" "188.8" "" "" "" "" "" "" "" "" "" "" "231.6" "211.1" "189.2" "183.9" "223.3" "233.5" "234.7" "197.6" "180.0" "188.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-902532758451743562" "False" "High" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "0.000" "False" "24.694" "15" "4" "5" "4" "276" "30.0" "5.30" "18.17" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "0.908" "0.769" "0.927" "0.894" "0.747" "0.902" "0.882" "0.856" "0.421" "182.3" "165.5" "140.1" "169.0" "163.0" "136.1" "164.4" "160.8" "156.0" "76.8" "" "" "" "" "" "" "" "" "" "" "164.5" "127.6" "108.3" "113.8" "136.0" "116.2" "139.5" "116.4" "105.2" "76.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141936988023863748" "False" "High" "IsMasterProtein" "Q9NP61" "ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1" "0.000" "False" "24.681" "15" "8" "9" "8" "516" "56.9" "7.36" "26.98" "8" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "26286" "ENSG00000242247" "ARFGAP3" "E9PB03; hsa:26286; Q9BSC6; Q9H9J0; Q9NP61; Q9NT10; Q9NUP5; Q9Y4V3; Q9Y4V4" "COPI-mediated anterograde transport; CDC42 GTPase cycle; RHOG GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic" "Ciliary landscape" "5" "0" "1.039" "0.981" "1.001" "1.058" "0.880" "1.028" "1.094" "0.936" "1.085" "689.2" "715.9" "676.0" "689.6" "729.2" "606.3" "708.8" "754.0" "644.8" "747.6" "" "" "" "" "" "" "" "" "" "" "622.2" "552.2" "522.8" "464.4" "608.2" "517.5" "601.2" "545.6" "434.9" "747.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570551838394526128" "False" "High" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "0.000" "False" "24.628" "16" "6" "7" "6" "386" "43.8" "7.20" "21.88" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "Network map of SARS-CoV-2 signaling pathway" "3" "0" "1.027" "0.947" "1.153" "0.983" "0.789" "0.975" "0.972" "0.949" "1.103" "178.2" "183.1" "168.8" "205.5" "175.3" "140.7" "173.9" "173.2" "169.1" "196.5" "" "" "" "" "" "" "" "" "" "" "160.9" "141.2" "130.5" "138.4" "146.2" "120.1" "147.5" "125.4" "114.1" "196.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1274747088330592999" "False" "High" "IsMasterProtein" "O94973" "AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2" "0.000" "False" "24.617" "7" "7" "9" "1" "939" "103.9" "6.96" "27.58" "7" "transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02296, Pf02883" "161" "ENSG00000183020" "AP2A2" "hsa:161; O75403; O94973; Q53ET1; Q96SI8" "MHC class II antigen presentation; Potential therapeutics for SARS; Recycling pathway of L1; Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "18" "0" "1.105" "1.201" "0.953" "0.939" "0.880" "0.798" "0.718" "1.127" "0.774" "37.5" "41.5" "45.1" "35.8" "35.2" "33.0" "30.0" "27.0" "42.3" "29.1" "" "" "" "" "" "" "" "" "" "" "33.9" "32.0" "34.9" "24.1" "29.4" "28.2" "25.4" "19.5" "28.5" "29.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8973056022317677667" "False" "High" "IsMasterProtein" "Q9BVS4" "Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2" "0.000" "False" "24.563" "12" "6" "7" "6" "552" "63.2" "5.94" "19.36" "6" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163, Pf09202" "55781" "ENSG00000058729" "RIOK2" "D6RDI3; hsa:55781; Q9BVS4; Q9NUT0" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.932" "0.758" "0.857" "0.931" "0.791" "0.800" "0.978" "0.787" "0.819" "260.4" "242.8" "197.5" "223.2" "242.5" "206.0" "208.3" "254.7" "205.1" "213.3" "" "" "" "" "" "" "" "" "" "" "235.1" "187.3" "152.7" "150.3" "202.3" "175.8" "176.7" "184.3" "138.3" "213.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5641944312381893453" "False" "High" "IsMasterProtein" "Q8IYB7" "DIS3-like exonuclease 2 OS=Homo sapiens OX=9606 GN=DIS3L2 PE=1 SV=4" "0.000" "False" "24.559" "6" "6" "7" "6" "885" "99.2" "6.10" "19.45" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf17216, Pf17849, Pf17877" "129563" "ENSG00000144535" "DIS3L2" "hsa:129563; Q53S79; Q580W6; Q5XKH0; Q69YG5; Q6AW99; Q7Z4T6; Q8IYB7; Q8N9K9" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "" "1" "0" "1.028" "0.984" "1.187" "1.060" "0.893" "1.044" "1.062" "1.109" "1.153" "339.5" "349.1" "334.0" "402.9" "359.7" "303.1" "354.4" "360.6" "376.5" "391.6" "" "" "" "" "" "" "" "" "" "" "306.4" "269.2" "258.3" "271.3" "300.1" "258.7" "300.6" "260.9" "254.0" "391.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7303961078788059209" "False" "High" "IsMasterProtein" "P49792" "E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2" "0.000" "False" "24.552" "3" "8" "8" "7" "3224" "358.0" "6.20" "22.82" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00160, Pf00638, Pf00641, Pf12185" "5903" "ENSG00000153201" "RANBP2" "hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7" "Transport of Mature mRNA derived from an Intron-Containing Transcript; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)" "" "35" "0" "0.987" "1.674" "1.134" "1.260" "1.576" "1.286" "1.014" "1.595" "6.210" "157.2" "155.2" "263.1" "178.2" "198.0" "247.7" "202.1" "159.4" "250.6" "976.0" "" "" "" "" "" "" "" "" "" "" "141.9" "119.7" "203.5" "120.0" "165.2" "211.4" "171.4" "115.4" "169.0" "976.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802113826893248650" "False" "High" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "0.000" "False" "24.534" "32" "2" "9" "2" "87" "10.0" "6.57" "27.40" "2" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Mitochondrial Fatty Acid Beta-Oxidation" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "6" "0" "0.909" "1.103" "1.053" "1.002" "1.040" "1.037" "1.094" "1.065" "0.608" "559.0" "508.2" "616.5" "588.5" "560.1" "581.4" "579.6" "611.5" "595.4" "339.8" "" "" "" "" "" "" "" "" "" "" "504.6" "392.0" "476.8" "396.3" "467.2" "496.2" "491.6" "442.5" "401.6" "339.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2776993726351284183" "False" "High" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "0.000" "False" "24.507" "8" "5" "7" "5" "771" "87.9" "7.87" "20.40" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "0.997" "1.013" "0.936" "1.055" "0.993" "0.952" "0.967" "1.025" "0.609" "407.5" "406.3" "413.0" "381.4" "430.1" "404.6" "387.9" "393.9" "417.6" "248.2" "" "" "" "" "" "" "" "" "" "" "367.9" "313.4" "319.4" "256.8" "358.8" "345.4" "329.1" "285.1" "281.7" "248.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6736379060781022662" "False" "High" "IsMasterProtein" "P21399" "Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3" "0.000" "False" "24.480" "8" "7" "8" "7" "889" "98.3" "6.68" "20.57" "7" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "48" "ENSG00000122729" "ACO1" "D3DRK7; hsa:48; P21399; Q14652; Q5VZA7" "Iron uptake and transport" "Iron metabolism in placenta; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)" "3" "0" "0.914" "1.041" "1.025" "0.992" "1.093" "0.982" "0.925" "1.073" "1.258" "348.2" "318.3" "362.4" "357.0" "345.5" "380.4" "341.9" "322.1" "373.7" "438.0" "" "" "" "" "" "" "" "" "" "" "314.3" "245.6" "280.3" "240.4" "288.2" "324.7" "290.0" "233.1" "252.0" "438.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1799847195195984928" "False" "High" "IsMasterProtein" "Q5VYK3" "Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2" "0.000" "False" "24.457" "4" "7" "9" "7" "1845" "204.2" "7.12" "24.02" "7" "cell organization and biogenesis" "cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12755, Pf13001" "23392" "ENSG00000136813" "ECPAS" "A0A804HJA4; B3KXF2; O15074; Q5VYK3; Q8WU82" "" "" "0" "0" "0.934" "0.995" "0.942" "0.922" "0.933" "1.012" "0.816" "0.854" "2.793" "375.6" "350.9" "373.7" "353.8" "346.2" "350.3" "380.2" "306.6" "321.0" "1049.0" "" "" "" "" "" "" "" "" "" "" "339.1" "270.7" "289.1" "238.3" "288.8" "299.0" "322.6" "221.9" "216.5" "1049.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6811152372553307115" "False" "High" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "0.000" "False" "24.454" "10" "5" "7" "5" "529" "59.5" "8.92" "23.27" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "" "3" "0" "1.080" "0.981" "1.167" "1.273" "0.971" "1.058" "1.131" "1.039" "1.136" "189.9" "205.1" "186.3" "221.7" "241.7" "184.4" "201.0" "214.8" "197.4" "215.8" "" "" "" "" "" "" "" "" "" "" "171.4" "158.2" "144.1" "149.3" "201.6" "157.4" "170.5" "155.4" "133.1" "215.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901270763620924094" "False" "High" "IsMasterProtein" "Q6P1N9" "Deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "0.000" "False" "24.453" "20" "6" "6" "6" "297" "33.6" "6.96" "19.86" "6" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687; ENSG00000291730" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "0.881" "1.023" "0.977" "0.923" "0.984" "0.845" "0.864" "0.993" "0.691" "207.5" "182.7" "212.3" "202.6" "191.5" "204.0" "175.3" "179.3" "206.0" "143.4" "" "" "" "" "" "" "" "" "" "" "187.3" "140.9" "164.2" "136.4" "159.8" "174.1" "148.7" "129.7" "139.0" "143.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415570283207223737" "False" "High" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "0.000" "False" "24.451" "21" "7" "7" "7" "329" "35.2" "8.44" "23.45" "7" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "0.933" "0.901" "0.981" "0.916" "1.050" "0.848" "0.845" "1.091" "0.636" "292.9" "273.1" "263.8" "287.2" "268.4" "307.5" "248.4" "247.6" "319.5" "186.2" "" "" "" "" "" "" "" "" "" "" "264.4" "210.7" "204.0" "193.4" "223.9" "262.4" "210.8" "179.2" "215.5" "186.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1698483045954744258" "False" "High" "IsMasterProtein" "Q15018" "BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2" "0.000" "False" "24.446" "12" "5" "5" "5" "415" "46.9" "6.21" "18.11" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21125" "23172" "ENSG00000165660" "ABRAXAS2" "B4DKR2; hsa:23172; Q15018; Q96H11" "Metalloprotease DUBs" "" "1" "0" "0.998" "0.948" "1.075" "1.023" "0.984" "1.008" "0.943" "1.003" "0.788" "409.3" "408.7" "388.2" "439.9" "418.7" "402.7" "412.6" "386.1" "410.5" "322.6" "" "" "" "" "" "" "" "" "" "" "369.5" "315.2" "300.3" "296.2" "349.3" "343.7" "350.0" "279.4" "276.9" "322.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3391234540397172253" "False" "High" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "0.000" "False" "24.405" "8" "7" "10" "7" "1008" "114.7" "7.68" "20.27" "7" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "VEGFA-VEGFR2 signaling" "2" "0" "1.053" "0.915" "0.777" "0.971" "0.821" "0.874" "0.927" "0.855" "1.040" "115.6" "121.8" "105.7" "89.8" "112.2" "94.9" "101.1" "107.1" "98.9" "120.3" "" "" "" "" "" "" "" "" "" "" "104.3" "93.9" "81.8" "60.5" "93.6" "81.0" "85.7" "77.5" "66.7" "120.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8834965082719872925" "False" "High" "IsMasterProtein" "Q96EQ0" "Small glutamine-rich tetratricopeptide repeat-containing protein beta OS=Homo sapiens OX=9606 GN=SGTB PE=1 SV=1" "0.000" "False" "24.352" "18" "5" "8" "5" "304" "33.4" "4.92" "23.09" "5" "cell organization and biogenesis;other biological processes" "other membranes;cytosol" "other molecular function" "Pf00515, Pf13414, Pf16546" "54557" "ENSG00000197860" "SGTB" "hsa:54557; Q96EQ0" "" "" "0" "0" "1.065" "1.085" "0.956" "1.004" "1.045" "1.077" "1.125" "1.063" "0.920" "229.4" "244.4" "248.8" "219.3" "230.2" "239.7" "247.1" "258.0" "243.8" "210.9" "" "" "" "" "" "" "" "" "" "" "207.1" "188.5" "192.4" "147.7" "192.1" "204.6" "209.6" "186.7" "164.5" "210.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982542769367786087" "False" "High" "IsMasterProtein" "O75116" "Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4" "0.000" "False" "24.352" "4" "6" "7" "4" "1388" "160.8" "6.02" "22.50" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "9475" "ENSG00000134318" "ROCK2" "hsa:9475; O75116; Q53QZ0; Q53SJ7; Q9UQN5" "Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "27" "0" "0.973" "0.908" "0.910" "0.925" "0.777" "0.984" "0.862" "0.850" "2.406" "225.6" "219.4" "204.8" "205.2" "208.6" "175.2" "222.0" "194.5" "191.7" "542.8" "" "" "" "" "" "" "" "" "" "" "203.6" "169.3" "158.4" "138.2" "174.0" "149.5" "188.3" "140.8" "129.3" "542.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8173179408617438185" "False" "High" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "0.000" "False" "24.320" "15" "5" "9" "5" "405" "44.5" "6.70" "21.65" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "12" "0" "0.990" "1.092" "0.981" "1.064" "1.127" "1.038" "1.071" "1.087" "0.889" "496.5" "491.4" "542.2" "487.1" "528.2" "559.6" "515.3" "531.6" "539.7" "441.6" "" "" "" "" "" "" "" "" "" "" "448.2" "379.0" "419.4" "328.0" "440.6" "477.7" "437.1" "384.7" "364.0" "441.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4996953049836216410" "False" "High" "IsMasterProtein" "O14618" "Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1" "0.000" "False" "24.302" "19" "6" "9" "6" "274" "29.0" "5.58" "27.81" "6" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00080, Pf00403" "9973" "ENSG00000173992" "CCS" "hsa:9973; O14618; Q2M366; Q8NEV0" "Detoxification of Reactive Oxygen Species" "Amyotrophic lateral sclerosis (ALS); Copper homeostasis" "3" "0" "0.958" "0.858" "1.103" "0.973" "0.933" "0.978" "0.988" "0.998" "1.098" "303.3" "290.7" "260.3" "334.5" "295.2" "283.0" "296.7" "299.8" "302.8" "332.9" "" "" "" "" "" "" "" "" "" "" "273.8" "224.3" "201.3" "225.3" "246.3" "241.5" "251.7" "217.0" "204.3" "332.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260610778738387308" "False" "High" "IsMasterProtein" "Q13907" "Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2" "0.000" "False" "24.290" "20" "4" "11" "4" "227" "26.3" "6.34" "32.48" "4" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00293" "3422" "ENSG00000067064" "IDI1" "B4E155; hsa:3422; Q13907; Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Exercise-induced circadian regulation; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "11" "0" "0.985" "1.016" "0.982" "0.865" "1.036" "0.923" "0.952" "0.998" "0.856" "296.1" "291.6" "300.9" "290.7" "256.1" "306.8" "273.3" "281.7" "295.6" "253.4" "" "" "" "" "" "" "" "" "" "" "267.3" "225.0" "232.7" "195.8" "213.6" "261.9" "231.8" "203.9" "199.4" "253.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "515980508248597386" "False" "High" "IsMasterProtein" "Q5T1V6" "Probable ATP-dependent RNA helicase DDX59 OS=Homo sapiens OX=9606 GN=DDX59 PE=1 SV=1" "0.000" "False" "24.285" "7" "4" "5" "4" "619" "68.8" "7.44" "15.69" "4" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04438" "83479" "ENSG00000118197" "DDX59" "hsa:83479; Q5T1V6; Q6PJL2; Q8IVW3; Q9H0W3" "" "Ciliopathies" "1" "0" "1.005" "0.848" "1.036" "1.067" "0.790" "0.990" "0.984" "0.854" "0.957" "185.2" "186.2" "157.0" "191.9" "197.6" "146.3" "183.5" "182.3" "158.3" "177.3" "" "" "" "" "" "" "" "" "" "" "167.2" "143.6" "121.5" "129.2" "164.8" "124.9" "155.6" "131.9" "106.7" "177.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4996428185622591073" "False" "High" "IsMasterProtein" "Q9NZB2" "Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2" "0.000" "False" "24.283" "4" "4" "7" "4" "1118" "121.8" "8.88" "19.57" "4" "" "plasma membrane;other membranes;cytosol;nucleus" "" "" "23196" "ENSG00000048828" "FAM120A" "A6NGU0; C4AMC6; hsa:23196; O60649; Q14688; Q4VXF4; Q4VXF5; Q4VXG2; Q86V69; Q96I21; Q9NZB1; Q9NZB2" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.996" "0.874" "1.079" "0.967" "0.980" "0.941" "0.870" "0.939" "0.975" "183.8" "183.1" "160.6" "198.4" "177.7" "180.2" "172.9" "159.9" "172.6" "179.3" "" "" "" "" "" "" "" "" "" "" "165.9" "141.3" "124.2" "133.6" "148.2" "153.8" "146.7" "115.7" "116.4" "179.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2928934229844812076" "False" "High" "IsMasterProtein" "Q8TCD5" "5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2" "0.000" "False" "24.258" "27" "5" "9" "5" "201" "23.4" "6.64" "28.75" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06941" "30833" "ENSG00000125458" "NT5C" "hsa:30833; Q8TCD5; Q96HS6; Q9NP82" "Purine catabolism; Pyrimidine catabolism" "Pyrimidine metabolism" "3" "0" "1.106" "1.017" "1.052" "1.039" "1.094" "1.063" "1.152" "1.139" "0.776" "289.2" "319.9" "294.0" "304.3" "300.4" "316.2" "307.3" "333.1" "329.4" "224.4" "" "" "" "" "" "" "" "" "" "" "261.0" "246.7" "227.4" "204.9" "250.6" "269.9" "260.6" "241.1" "222.2" "224.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3469585503029869905" "False" "High" "IsMasterProtein" "Q96PU5" "E3 ubiquitin-protein ligase NEDD4-like OS=Homo sapiens OX=9606 GN=NEDD4L PE=1 SV=2" "0.000" "False" "24.223" "10" "9" "10" "9" "975" "111.9" "5.82" "26.99" "9" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf00397, Pf00632" "23327" "ENSG00000049759" "NEDD4L" "hsa:23327; O43165; Q3LSM7; Q7Z5F1; Q7Z5F2; Q7Z5N3; Q8N5A7; Q8WUU9; Q96PU5; Q9BW58; Q9H2W4; Q9NT88" "Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Stimuli-sensing channels; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "TGF-beta signaling pathway" "6" "0" "1.027" "0.941" "1.051" "1.071" "0.922" "0.953" "0.914" "1.049" "2.512" "143.5" "147.3" "135.1" "150.8" "153.7" "132.3" "136.7" "131.2" "150.5" "360.5" "" "" "" "" "" "" "" "" "" "" "129.5" "113.6" "104.5" "101.5" "128.2" "112.9" "116.0" "94.9" "101.5" "360.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7302016058410828571" "False" "High" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "0.000" "False" "24.216" "9" "2" "4" "2" "238" "26.7" "7.24" "10.80" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "mRNA Splicing - Major Pathway" "" "1" "0" "1.195" "0.960" "0.965" "1.023" "0.961" "1.081" "1.091" "0.911" "0.749" "197.5" "236.0" "189.5" "190.6" "202.0" "189.7" "213.5" "215.4" "180.0" "148.0" "" "" "" "" "" "" "" "" "" "" "178.3" "182.0" "146.6" "128.3" "168.5" "162.0" "181.1" "155.9" "121.4" "148.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4992003344612717305" "False" "High" "IsMasterProtein" "P30260" "Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2" "0.000" "False" "24.111" "6" "4" "6" "4" "824" "91.8" "7.02" "22.60" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00515, Pf12895" "996" "ENSG00000004897" "CDC27" "G3V1C4; hsa:996; P30260; Q16349; Q96F35" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle; 2q21.1 copy number variation syndrome" "20" "0" "0.921" "0.961" "1.077" "1.005" "0.913" "1.005" "0.886" "0.931" "0.910" "256.7" "236.3" "246.6" "276.4" "258.0" "234.3" "258.1" "227.4" "239.1" "233.6" "" "" "" "" "" "" "" "" "" "" "231.7" "182.3" "190.7" "186.1" "215.2" "199.9" "218.9" "164.6" "161.3" "233.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7328219287373480262" "False" "High" "IsMasterProtein" "Q7LG56" "Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1" "0.000" "False" "24.102" "18" "6" "9" "4" "351" "40.7" "4.97" "27.79" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00268" "50484" "ENSG00000048392" "RRM2B" "B4E2N4; hsa:50484; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q7LG56; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3" "Interconversion of nucleotide di- and triphosphates; TP53 Regulates Metabolic Genes" "miRNA regulation of DNA damage response; Pyrimidine metabolism; p53 transcriptional gene network; DNA damage response" "6" "0" "0.994" "1.035" "0.917" "0.919" "0.952" "1.008" "1.014" "0.982" "0.711" "395.9" "393.7" "409.6" "363.2" "363.9" "376.8" "399.2" "401.7" "388.6" "281.6" "" "" "" "" "" "" "" "" "" "" "357.4" "303.7" "316.8" "244.5" "303.6" "321.6" "338.6" "290.7" "262.1" "281.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1957491016862499710" "False" "High" "IsMasterProtein" "P13073" "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" "0.000" "False" "24.067" "18" "3" "9" "3" "169" "19.6" "9.51" "19.47" "3" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion;nucleus" "transporter activity" "Pf02936" "1327" "ENSG00000131143" "COX4I1" "B2R4J2; D3DUM7; hsa:1327; P13073; Q6P666" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "8" "0" "1.129" "1.298" "0.946" "1.014" "1.208" "1.094" "1.199" "1.239" "0.749" "215.1" "242.9" "279.1" "203.5" "218.2" "259.9" "235.3" "257.9" "266.6" "161.2" "" "" "" "" "" "" "" "" "" "" "194.1" "187.4" "215.9" "137.0" "182.0" "221.8" "199.6" "186.7" "179.8" "161.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8542796064985296864" "False" "High" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "0.000" "False" "24.056" "10" "4" "6" "4" "492" "52.0" "6.48" "20.32" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "tRNA modification in the mitochondrion" "" "1" "0" "1.003" "0.900" "0.978" "1.085" "0.749" "0.880" "1.002" "0.897" "0.793" "79.0" "79.2" "71.1" "77.3" "85.7" "59.2" "69.5" "79.1" "70.9" "62.6" "" "" "" "" "" "" "" "" "" "" "71.3" "61.1" "55.0" "52.0" "71.5" "50.5" "59.0" "57.2" "47.8" "62.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1014508030414011044" "False" "High" "IsMasterProtein" "P62899" "Large ribosomal subunit protein eL31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "0.000" "False" "24.028" "29" "5" "12" "5" "125" "14.5" "10.54" "38.59" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.936" "1.209" "1.022" "1.006" "0.993" "1.019" "1.118" "1.071" "0.383" "942.4" "881.8" "1139.7" "963.1" "948.1" "936.0" "960.0" "1053.6" "1009.0" "361.3" "" "" "" "" "" "" "" "" "" "" "850.7" "680.2" "881.5" "648.5" "790.9" "798.9" "814.3" "762.5" "680.5" "361.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4023730213020721894" "False" "High" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "0.000" "False" "23.995" "8" "4" "5" "4" "485" "53.3" "7.34" "17.61" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "" "17q12 copy number variation syndrome" "1" "0" "0.911" "0.896" "0.994" "0.975" "1.020" "0.986" "0.988" "0.953" "0.980" "308.2" "280.9" "276.3" "306.2" "300.6" "314.5" "303.9" "304.4" "293.8" "301.9" "" "" "" "" "" "" "" "" "" "" "278.2" "216.7" "213.7" "206.2" "250.8" "268.4" "257.8" "220.3" "198.2" "301.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4234558439794556747" "False" "High" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "0.000" "False" "23.992" "10" "6" "7" "6" "521" "56.7" "7.99" "25.26" "6" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "CDC42 GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "IL-18 signaling pathway; 5q35 copy number variation" "5" "0" "0.880" "0.856" "0.882" "1.012" "0.734" "0.969" "0.867" "0.796" "1.657" "378.1" "332.7" "323.5" "333.3" "382.8" "277.6" "366.3" "327.7" "301.1" "626.4" "" "" "" "" "" "" "" "" "" "" "341.3" "256.6" "250.2" "224.5" "319.3" "236.9" "310.7" "237.2" "203.1" "626.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5978569898189539548" "False" "High" "IsMasterProtein" "O75694" "Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1" "0.000" "False" "23.953" "5" "8" "9" "8" "1391" "155.1" "6.16" "25.73" "8" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf08801" "9631" "ENSG00000113569" "NUP155" "hsa:9631; O75694; Q9UBE9; Q9UFL5" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "0.969" "0.932" "0.964" "1.074" "0.920" "0.964" "0.988" "0.956" "0.967" "325.0" "315.1" "302.9" "313.3" "349.0" "299.1" "313.4" "321.3" "310.8" "314.4" "" "" "" "" "" "" "" "" "" "" "293.4" "243.0" "234.3" "211.0" "291.1" "255.3" "265.9" "232.5" "209.7" "314.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6364343737777032179" "False" "High" "IsMasterProtein" "P08754" "Guanine nucleotide-binding protein G(i) subunit alpha-3 OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3" "0.000" "False" "23.935" "19" "6" "8" "3" "354" "40.5" "5.69" "16.55" "6" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2773" "ENSG00000065135" "GNAI3" "hsa:2773; P08754; P17539; Q5TZX1" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production" "Thyroid stimulating hormone (TSH) signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "18" "0" "0.927" "0.865" "0.982" "0.861" "0.781" "1.102" "1.046" "0.806" "0.544" "125.0" "115.9" "108.2" "122.8" "107.7" "97.7" "137.8" "130.8" "100.8" "68.0" "" "" "" "" "" "" "" "" "" "" "112.9" "89.4" "83.7" "82.7" "89.8" "83.4" "116.9" "94.6" "68.0" "68.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181785604482644820" "False" "High" "IsMasterProtein" "Q9NR50" "Translation initiation factor eIF2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1" "0.000" "False" "23.915" "12" "5" "6" "5" "452" "50.2" "6.47" "16.72" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00483" "8891" "ENSG00000070785" "EIF2B3" "B2RBH8; D3DPZ2; hsa:8891; Q5QP89; Q5QP90; Q8NDB5; Q8WV57; Q9H850; Q9NR50" "Recycling of eIF2:GDP" "Translation factors; Primary ovarian insufficiency" "3" "0" "1.072" "0.872" "0.973" "1.010" "0.859" "1.126" "1.032" "0.784" "0.932" "353.3" "378.9" "307.9" "343.8" "357.0" "303.3" "398.0" "364.5" "277.0" "329.3" "" "" "" "" "" "" "" "" "" "" "318.9" "292.2" "238.1" "231.5" "297.8" "258.9" "337.6" "263.8" "186.8" "329.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697914900789617779" "False" "High" "IsMasterProtein" "Q7RTV0" "PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1" "0.000" "False" "23.884" "39" "5" "8" "5" "110" "12.4" "8.41" "24.24" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03660" "84844" "ENSG00000100410" "PHF5A" "hsa:84844; Q7RTV0; Q9UH06" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.951" "0.953" "0.922" "0.964" "0.890" "1.044" "1.103" "0.898" "0.608" "924.9" "879.6" "881.6" "853.1" "892.0" "823.3" "965.9" "1020.2" "831.0" "562.0" "" "" "" "" "" "" "" "" "" "" "834.9" "678.5" "681.8" "574.5" "744.1" "702.7" "819.4" "738.3" "560.5" "562.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8706245126759521959" "False" "High" "IsMasterProtein" "Q9BRP4" "Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2" "0.000" "False" "23.839" "20" "8" "9" "8" "392" "42.2" "6.32" "22.04" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80227" "ENSG00000175575" "PAAF1" "A6NDR5; B4DPB0; B7ZAS9; hsa:80227; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9BRP4; Q9HAB6" "" "" "0" "0" "0.930" "0.928" "1.121" "0.986" "0.762" "1.044" "0.953" "0.929" "0.791" "153.4" "142.6" "142.4" "171.9" "151.2" "116.9" "160.1" "146.1" "142.4" "121.3" "" "" "" "" "" "" "" "" "" "" "138.4" "110.0" "110.1" "115.8" "126.1" "99.8" "135.8" "105.7" "96.1" "121.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3168317114658066086" "False" "High" "IsMasterProtein" "Q9UH03" "Neuronal-specific septin-3 OS=Homo sapiens OX=9606 GN=SEPTIN3 PE=1 SV=3" "0.000" "False" "23.810" "13" "5" "8" "5" "358" "40.7" "7.20" "26.18" "5" "cell cycle OR cell proliferation" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55964" "ENSG00000100167" "SEPTIN3" "B1AHR0; hsa:55964; Q2NKJ7; Q59GF7; Q6IBZ6; Q8N3P3; Q9HD35; Q9UH03" "" "" "0" "0" "1.022" "1.078" "1.011" "1.009" "1.073" "1.024" "1.025" "1.070" "0.805" "924.7" "945.1" "997.2" "935.3" "933.3" "991.9" "947.2" "947.9" "989.3" "744.1" "" "" "" "" "" "" "" "" "" "" "834.7" "729.0" "771.2" "629.8" "778.6" "846.6" "803.5" "686.0" "667.3" "744.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912307548831863099" "False" "High" "IsMasterProtein" "P25398" "Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "0.000" "False" "23.805" "28" "4" "12" "4" "132" "14.5" "7.21" "36.44" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.922" "1.062" "0.805" "0.933" "1.157" "0.911" "1.108" "1.043" "0.578" "657.5" "606.5" "698.5" "529.6" "613.4" "760.4" "598.9" "728.8" "685.6" "380.2" "" "" "" "" "" "" "" "" "" "" "593.5" "467.8" "540.3" "356.6" "511.7" "649.1" "508.0" "527.4" "462.4" "380.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1603503262744250251" "False" "High" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C16 PE=1 SV=2" "0.000" "False" "23.803" "27" "3" "11" "3" "103" "11.4" "11.36" "32.98" "3" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; SUMOylation of chromatin organization proteins; HCMV Late Events; Amyloid fiber formation; Meiotic synapsis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling" "52" "0" "1.197" "1.292" "1.078" "1.325" "1.564" "1.212" "1.151" "1.448" "1.375" "508.2" "608.2" "656.6" "547.7" "673.2" "794.9" "616.1" "584.9" "735.7" "698.7" "" "" "" "" "" "" "" "" "" "" "458.7" "469.1" "507.8" "368.8" "561.5" "678.5" "522.6" "423.3" "496.2" "698.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3946682035619075212" "False" "High" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "0.000" "False" "23.768" "20" "4" "9" "4" "224" "25.2" "9.28" "30.13" "4" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "1.006" "1.020" "1.049" "1.021" "1.001" "1.006" "1.056" "1.029" "0.693" "752.0" "756.8" "767.0" "788.9" "767.7" "752.6" "756.2" "793.7" "773.5" "520.9" "" "" "" "" "" "" "" "" "" "" "678.8" "583.7" "593.2" "531.3" "640.4" "642.4" "641.5" "574.4" "521.7" "520.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8735053905858643513" "False" "High" "IsMasterProtein" "Q16401" "26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3" "0.000" "False" "23.735" "12" "7" "11" "7" "504" "56.2" "5.48" "30.93" "7" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf10508" "5711" "ENSG00000095261" "PSMD5" "B4DZM8; hsa:5711; Q15045; Q16401; Q4VXG8" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "61" "0" "1.037" "0.855" "1.021" "1.046" "0.851" "0.998" "0.948" "0.853" "0.997" "407.3" "422.2" "348.3" "416.0" "426.0" "346.7" "406.4" "386.2" "347.4" "406.1" "" "" "" "" "" "" "" "" "" "" "367.7" "325.7" "269.4" "280.1" "355.3" "295.9" "344.8" "279.5" "234.3" "406.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4122456609389434317" "False" "High" "IsMasterProtein" "Q04724" "Transducin-like enhancer protein 1 OS=Homo sapiens OX=9606 GN=TLE1 PE=1 SV=2" "0.000" "False" "23.720" "6" "5" "9" "1" "770" "83.1" "7.24" "28.01" "5" "cell-cell signaling;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7088" "ENSG00000196781" "TLE1" "A8K495; hsa:7088; Q04724; Q5T3G4; Q969V9" "Deactivation of the beta-catenin transactivating complex; NOTCH1 Intracellular Domain Regulates Transcription; Formation of the beta-catenin:TCF transactivating complex; Repression of WNT target genes" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Notch signaling pathway" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5219962160653880547" "False" "High" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "0.000" "False" "23.672" "21" "6" "6" "6" "309" "34.5" "8.98" "19.45" "6" "other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "1.102" "0.879" "0.979" "0.965" "0.915" "0.932" "0.713" "0.997" "5.409" "216.7" "238.8" "190.4" "212.2" "209.2" "198.2" "201.9" "154.4" "216.0" "1172.0" "" "" "" "" "" "" "" "" "" "" "195.6" "184.2" "147.2" "142.9" "174.5" "169.1" "171.3" "111.8" "145.7" "1172.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3037731205086659877" "False" "High" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "0.000" "False" "23.672" "25" "3" "5" "3" "159" "17.4" "9.67" "16.51" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "mRNA Splicing - Major Pathway" "" "1" "0" "1.010" "1.207" "1.002" "1.028" "1.126" "0.965" "1.045" "1.035" "0.797" "378.4" "382.3" "456.6" "379.3" "389.1" "426.2" "365.3" "395.4" "391.8" "301.8" "" "" "" "" "" "" "" "" "" "" "341.6" "294.9" "353.2" "255.4" "324.6" "363.7" "309.9" "286.1" "264.2" "301.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2449426517635308859" "False" "High" "IsMasterProtein" "Q9H6F5" "Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1" "0.000" "False" "23.657" "13" "4" "7" "4" "360" "40.2" "10.33" "24.03" "4" "" "nucleus;other cell component" "" "Pf03879" "79080" "ENSG00000110104" "CCDC86" "B4DY99; hsa:79080; Q9H6F5" "" "" "0" "0" "1.066" "0.957" "1.047" "0.990" "1.082" "1.004" "0.993" "0.948" "0.695" "420.2" "447.9" "402.1" "439.8" "416.2" "454.9" "421.7" "417.2" "398.6" "291.9" "" "" "" "" "" "" "" "" "" "" "379.3" "345.5" "311.0" "296.2" "347.2" "388.2" "357.8" "301.9" "268.8" "291.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6175620915795625691" "False" "High" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "0.000" "False" "23.620" "14" "4" "12" "3" "305" "30.8" "9.29" "37.18" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "1.074" "2.937" "1.076" "1.113" "2.828" "1.086" "0.525" "2.750" "10.657" "138.7" "149.0" "407.4" "149.2" "154.4" "392.3" "150.7" "72.8" "381.5" "1478.4" "" "" "" "" "" "" "" "" "" "" "125.2" "115.0" "315.1" "100.5" "128.8" "334.8" "127.9" "52.7" "257.3" "1478.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1086503050039846823" "False" "High" "IsMasterProtein" "Q15847" "Adipogenesis regulatory factor OS=Homo sapiens OX=9606 GN=ADIRF PE=1 SV=1" "0.000" "False" "23.619" "38" "3" "11" "3" "76" "7.9" "5.31" "41.01" "3" "other biological processes" "cytosol;nucleus" "" "" "10974" "ENSG00000148671" "ADIRF" "hsa:10974; Q15847" "Transcriptional regulation of white adipocyte differentiation" "10q22q23 copy number variation" "2" "0" "0.991" "0.946" "0.972" "0.937" "0.930" "0.958" "1.064" "0.850" "0.616" "1574.6" "1559.7" "1489.4" "1531.1" "1475.5" "1465.0" "1507.7" "1674.6" "1339.0" "969.3" "" "" "" "" "" "" "" "" "" "" "1421.4" "1203.1" "1152.0" "1031.0" "1230.8" "1250.4" "1279.0" "1211.9" "903.1" "969.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3232925650926593770" "False" "High" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "0.000" "False" "23.611" "5" "7" "8" "7" "1729" "181.7" "4.86" "19.71" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "Ciliary landscape" "4" "0" "0.955" "0.975" "1.008" "0.970" "0.879" "0.878" "1.002" "0.942" "0.705" "430.9" "411.3" "420.0" "434.2" "417.8" "378.7" "378.1" "431.8" "405.7" "303.7" "" "" "" "" "" "" "" "" "" "" "389.0" "317.3" "324.8" "292.4" "348.5" "323.2" "320.8" "312.5" "273.7" "303.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7324571001266765675" "False" "High" "IsMasterProtein" "P29350" "Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1" "0.000" "False" "23.594" "13" "8" "9" "8" "595" "67.5" "7.78" "25.41" "8" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00017, Pf00102" "5777" "ENSG00000111679" "PTPN6" "A8K306; G3V0F8; hsa:5777; P29350; Q969V8; Q9UK67" "Neutrophil degranulation; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PD-1 signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signal regulatory protein family interactions; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; Signaling by ALK; Regulation of KIT signaling; Interleukin-37 signaling; Platelet sensitization by LDL; PECAM1 interactions; Nuclear events stimulated by ALK signaling in cancer" "Prolactin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; IL-3 signaling pathway; Kit receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways" "33" "0" "1.004" "1.019" "1.076" "1.123" "1.032" "1.100" "0.496" "1.144" "9.061" "207.4" "208.3" "211.4" "223.3" "232.9" "214.1" "228.1" "102.8" "237.2" "1879.5" "" "" "" "" "" "" "" "" "" "" "187.2" "160.7" "163.5" "150.3" "194.3" "182.8" "193.5" "74.4" "160.0" "1879.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6009675423733223461" "False" "High" "IsMasterProtein" "Q96B54" "Zinc finger protein 428 OS=Homo sapiens OX=9606 GN=ZNF428 PE=1 SV=2" "0.000" "False" "23.592" "22" "3" "5" "3" "188" "20.5" "4.17" "17.60" "3" "" "" "other molecular function" "" "126299" "ENSG00000131116" "ZNF428" "hsa:126299; O95054; Q6X3Y3; Q96B54" "" "" "0" "0" "0.811" "1.068" "1.112" "0.884" "0.961" "0.902" "0.993" "1.056" "0.718" "58.6" "47.5" "62.6" "65.1" "51.8" "56.3" "52.8" "58.1" "61.9" "42.1" "" "" "" "" "" "" "" "" "" "" "52.9" "36.6" "48.4" "43.9" "43.2" "48.0" "44.8" "42.1" "41.7" "42.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4185147082170088293" "False" "High" "IsMasterProtein" "Q9ULD0" "2-oxoglutarate dehydrogenase-like, mitochondrial OS=Homo sapiens OX=9606 GN=OGDHL PE=1 SV=3" "0.000" "False" "23.554" "7" "7" "8" "1" "1010" "114.4" "6.65" "22.23" "7" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "55753" "ENSG00000197444" "OGDHL" "A8K2G1; B4DKG2; B4E193; hsa:55753; Q8TAN9; Q9NVA0; Q9ULD0" "" "10q11.21q11.23 copy number variation syndrome" "1" "0" "0.907" "1.269" "1.117" "1.087" "1.267" "1.025" "1.091" "1.289" "2.043" "114.0" "103.4" "144.6" "127.3" "123.9" "144.4" "116.8" "124.3" "146.9" "232.8" "" "" "" "" "" "" "" "" "" "" "102.9" "79.7" "111.8" "85.7" "103.3" "123.2" "99.1" "90.0" "99.1" "232.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6983483800967602038" "False" "High" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "0.000" "False" "23.541" "8" "5" "7" "5" "706" "80.2" "6.70" "19.81" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.035" "0.832" "1.089" "0.981" "0.895" "0.964" "0.872" "0.967" "1.262" "221.4" "229.1" "184.3" "241.1" "217.2" "198.2" "213.5" "193.1" "214.1" "279.4" "" "" "" "" "" "" "" "" "" "" "199.9" "176.7" "142.6" "162.4" "181.1" "169.2" "181.1" "139.7" "144.4" "279.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822360151641721881" "False" "High" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "0.000" "False" "23.533" "19" "9" "10" "9" "518" "58.2" "8.13" "26.02" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Mitochondrial tRNA aminoacylation" "Selenium metabolism and selenoproteins" "2" "0" "1.130" "1.032" "1.174" "1.164" "1.014" "1.197" "1.276" "1.014" "0.972" "186.5" "210.7" "192.5" "218.9" "217.1" "189.0" "223.2" "237.9" "189.1" "181.2" "" "" "" "" "" "" "" "" "" "" "168.3" "162.5" "148.9" "147.4" "181.1" "161.3" "189.3" "172.2" "127.6" "181.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1721155162359169472" "False" "High" "IsMasterProtein" "Q9UBQ0" "Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1" "0.000" "False" "23.493" "26" "5" "8" "5" "182" "20.5" "6.79" "28.12" "5" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12850" "51699" "ENSG00000111237" "VPS29" "hsa:51699; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7; Q9UBQ0" "WNT ligand biogenesis and trafficking" "" "1" "0" "0.976" "1.069" "1.028" "1.083" "1.192" "1.020" "1.107" "1.099" "0.815" "614.7" "600.1" "657.4" "631.7" "665.5" "732.8" "627.2" "680.6" "675.7" "501.1" "" "" "" "" "" "" "" "" "" "" "554.9" "462.9" "508.5" "425.4" "555.1" "625.5" "532.1" "492.5" "455.8" "501.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219195248541824635" "False" "High" "IsMasterProtein" "Q92609" "TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1" "0.000" "False" "23.486" "8" "5" "6" "5" "795" "88.9" "6.54" "13.78" "5" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9779" "ENSG00000131374" "TBC1D5" "A6NP25; C9JP52; hsa:9779; Q92609" "" "" "0" "0" "1.022" "0.963" "0.988" "1.043" "1.008" "1.022" "1.019" "1.082" "1.787" "198.6" "203.1" "191.3" "196.2" "207.2" "200.3" "203.1" "202.5" "214.9" "355.1" "" "" "" "" "" "" "" "" "" "" "179.3" "156.6" "147.9" "132.1" "172.8" "171.0" "172.3" "146.5" "145.0" "355.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7690147936594120282" "False" "High" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "0.000" "False" "23.485" "14" "6" "7" "6" "361" "39.3" "7.18" "22.54" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "0.921" "0.945" "0.910" "0.984" "0.966" "1.046" "0.928" "1.046" "0.924" "326.5" "300.6" "308.7" "297.2" "321.2" "315.5" "341.5" "303.0" "341.6" "301.8" "" "" "" "" "" "" "" "" "" "" "294.8" "231.9" "238.7" "200.1" "268.0" "269.3" "289.7" "219.3" "230.4" "301.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8897927759308668761" "False" "High" "IsMasterProtein" "Q3KQV9" "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens OX=9606 GN=UAP1L1 PE=1 SV=2" "0.000" "False" "23.478" "10" "5" "6" "3" "507" "57.0" "6.32" "18.00" "5" "other metabolic processes" "" "other molecular function" "Pf01704" "91373" "ENSG00000197355" "UAP1L1" "A2AMJ8; hsa:91373; Q3KQV9; Q5SPZ2; Q69YQ3; Q6ZR38" "" "" "0" "0" "1.013" "0.737" "0.867" "1.087" "0.913" "0.861" "0.963" "0.758" "0.667" "49.1" "49.8" "36.2" "42.6" "53.4" "44.8" "42.3" "47.3" "37.2" "32.8" "" "" "" "" "" "" "" "" "" "" "44.3" "38.4" "28.0" "28.7" "44.5" "38.2" "35.9" "34.2" "25.1" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1860975273197737865" "False" "High" "IsMasterProtein" "P19784" "Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1" "0.000" "False" "23.445" "19" "5" "6" "5" "350" "41.2" "8.56" "18.75" "5" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1459" "ENSG00000070770" "CSNK2A2" "hsa:1459; P19784" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "21" "0" "1.011" "0.901" "1.001" "1.059" "1.014" "1.108" "1.027" "0.928" "1.181" "180.1" "182.1" "162.3" "180.2" "190.8" "182.7" "199.6" "185.0" "167.2" "212.6" "" "" "" "" "" "" "" "" "" "" "162.6" "140.5" "125.6" "121.4" "159.1" "155.9" "169.3" "133.9" "112.8" "212.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2934429115890705699" "False" "High" "IsMasterProtein" "P49821" "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4" "0.000" "False" "23.443" "12" "5" "9" "5" "464" "50.8" "8.21" "23.31" "5" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion" "transporter activity;other molecular function" "Pf01512, Pf10589" "4723" "ENSG00000167792" "NDUFV1" "hsa:4723; O60924; O60940; P49821; Q16104; Q6IBR3; Q96BF8; Q96HS7" "Mitochondrial protein degradation; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; HDAC6 interactions in the central nervous system; Oxidative phosphorylation" "7" "0" "1.034" "1.291" "1.030" "1.134" "1.306" "1.080" "1.191" "1.355" "0.567" "224.0" "231.7" "289.2" "230.7" "254.1" "292.7" "241.9" "266.9" "303.6" "127.1" "" "" "" "" "" "" "" "" "" "" "202.2" "178.7" "223.7" "155.4" "212.0" "249.8" "205.2" "193.1" "204.7" "127.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3461601812333061569" "False" "High" "IsMasterProtein" "Q9NRJ5" "Poly(A) polymerase beta OS=Homo sapiens OX=9606 GN=PAPOLB PE=1 SV=2" "0.000" "False" "23.440" "8" "5" "9" "1" "637" "71.8" "6.44" "23.55" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "56903" "ENSG00000218823" "PAPOLB" "hsa:56903; Q75LH1; Q8NE14; Q9NRJ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619075754329803082" "False" "High" "IsMasterProtein" "P17275" "Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1" "0.000" "False" "23.419" "16" "5" "7" "4" "347" "35.9" "9.22" "26.34" "5" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3726" "ENSG00000171223" "JUNB" "hsa:3726; P17275; Q96GH3" "NGF-stimulated transcription; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Oxidative stress response; Host-pathogen interaction of human coronaviruses - MAPK signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "18" "1" "0.978" "1.066" "0.992" "1.080" "0.930" "0.985" "1.061" "0.891" "0.785" "486.4" "475.7" "518.3" "482.4" "525.2" "452.3" "479.1" "515.9" "433.4" "381.8" "" "" "" "" "" "" "" "" "" "" "439.0" "366.9" "400.9" "324.9" "438.1" "386.1" "406.4" "373.4" "292.3" "381.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "777273144622755670" "False" "High" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "0.000" "False" "23.412" "8" "4" "5" "4" "535" "57.2" "8.28" "17.32" "4" "cell-cell signaling;other metabolic processes;developmental processes" "mitochondrion;other cell component" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Degradation of GABA" "Fragile X syndrome" "2" "0" "1.043" "1.015" "0.989" "1.062" "1.079" "0.959" "1.003" "1.113" "0.762" "382.1" "398.7" "387.8" "378.0" "405.9" "412.3" "366.6" "383.3" "425.3" "291.4" "" "" "" "" "" "" "" "" "" "" "344.9" "307.5" "300.0" "254.5" "338.6" "351.9" "311.0" "277.4" "286.8" "291.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4223527727478599420" "False" "High" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "0.000" "False" "23.403" "6" "4" "5" "4" "816" "91.3" "6.25" "21.33" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf21245" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "Synthesis of PIPs at the Golgi membrane" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144982604897555779" "False" "High" "IsMasterProtein" "P52306" "Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3" "0.000" "False" "23.402" "11" "6" "8" "6" "607" "66.3" "5.31" "22.56" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus" "enzyme regulator activity" "Pf00514" "5910" "ENSG00000138698" "RAP1GDS1" "E9PH06; G5E9P9; hsa:5910; P52306; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8" "RHOT2 GTPase cycle; RHOT1 GTPase cycle" "" "2" "0" "1.027" "0.848" "1.049" "0.878" "0.909" "1.015" "0.848" "0.927" "2.792" "201.9" "207.4" "171.3" "211.8" "177.3" "183.5" "204.9" "171.2" "187.2" "563.9" "" "" "" "" "" "" "" "" "" "" "182.3" "160.0" "132.5" "142.6" "147.9" "156.6" "173.8" "123.9" "126.2" "563.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5153257351632709387" "False" "High" "IsMasterProtein" "P26374" "Rab proteins geranylgeranyltransferase component A 2 OS=Homo sapiens OX=9606 GN=CHML PE=1 SV=2" "0.000" "False" "23.383" "11" "8" "8" "6" "656" "74.0" "4.93" "22.00" "8" "protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1122" "ENSG00000203668" "CHML" "B2RAB9; hsa:1122; P26374; Q17RE0; Q9H1Y4" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "" "2" "1" "0.952" "0.935" "0.875" "0.897" "1.050" "0.806" "0.976" "0.845" "0.900" "196.0" "186.6" "183.3" "171.6" "175.8" "205.9" "157.9" "191.3" "165.7" "176.3" "" "" "" "" "" "" "" "" "" "" "176.9" "144.0" "141.8" "115.5" "146.7" "175.7" "134.0" "138.5" "111.8" "176.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971041458510100973" "False" "High" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "0.000" "False" "23.375" "13" "7" "12" "7" "443" "51.6" "5.53" "32.34" "7" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "Ciliary landscape" "6" "0" "0.884" "0.942" "1.054" "0.891" "0.972" "1.010" "0.959" "0.957" "0.767" "286.4" "253.3" "269.7" "301.7" "255.2" "278.3" "289.2" "274.5" "274.0" "219.7" "" "" "" "" "" "" "" "" "" "" "258.5" "195.4" "208.6" "203.2" "212.8" "237.5" "245.3" "198.7" "184.8" "219.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8148433569690540229" "False" "High" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "0.000" "False" "23.367" "14" "4" "6" "4" "320" "33.6" "7.77" "18.14" "4" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Glutamate and glutamine metabolism" "Metabolic reprogramming in colon cancer" "2" "0" "0.946" "1.059" "1.056" "1.111" "0.936" "1.118" "1.126" "0.953" "0.692" "382.0" "361.2" "404.5" "403.3" "424.5" "357.6" "427.2" "430.1" "364.1" "264.3" "" "" "" "" "" "" "" "" "" "" "344.8" "278.6" "312.8" "271.6" "354.1" "305.2" "362.4" "311.2" "245.6" "264.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6270565792586481652" "False" "High" "IsMasterProtein" "Q9UHY7" "Enolase-phosphatase E1 OS=Homo sapiens OX=9606 GN=ENOPH1 PE=1 SV=1" "0.000" "False" "23.296" "15" "4" "7" "4" "261" "28.9" "4.78" "20.27" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00702" "58478" "ENSG00000145293" "ENOPH1" "hsa:58478; Q7Z4C5; Q9BVC2; Q9UHY7" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "0.880" "0.962" "0.867" "0.854" "0.982" "0.779" "0.816" "1.000" "1.198" "181.6" "159.9" "174.7" "157.3" "155.0" "178.4" "141.4" "148.2" "181.6" "217.5" "" "" "" "" "" "" "" "" "" "" "163.9" "123.3" "135.1" "105.9" "129.3" "152.2" "119.9" "107.2" "122.5" "217.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5796509123597455273" "False" "High" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "0.000" "False" "23.271" "9" "3" "4" "2" "356" "39.4" "7.20" "15.30" "3" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "1.099" "0.816" "1.232" "1.098" "0.889" "1.016" "1.084" "0.933" "0.953" "110.0" "120.8" "89.7" "135.5" "120.7" "97.8" "111.7" "119.1" "102.6" "104.7" "" "" "" "" "" "" "" "" "" "" "99.3" "93.2" "69.4" "91.2" "100.7" "83.5" "94.7" "86.2" "69.2" "104.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5217952952055268548" "False" "High" "IsMasterProtein" "P49207" "Large ribosomal subunit protein eL34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3" "0.000" "False" "23.247" "36" "5" "16" "5" "117" "13.3" "11.47" "44.92" "5" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01199" "6164" "ENSG00000109475" "RPL34" "hsa:6164; P49207; Q6FG66; Q9BUZ2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.885" "1.191" "0.786" "0.958" "0.974" "1.050" "1.042" "1.001" "0.293" "1077.8" "953.8" "1284.2" "847.6" "1032.1" "1050.4" "1131.5" "1123.0" "1078.8" "316.1" "" "" "" "" "" "" "" "" "" "" "972.9" "735.7" "993.2" "570.8" "860.9" "896.5" "959.9" "812.7" "727.7" "316.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694143023947037177" "False" "High" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "0.000" "False" "23.227" "15" "6" "8" "6" "445" "48.1" "7.12" "20.80" "6" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "Selenium metabolism and selenoproteins; 2q37 copy number variation syndrome" "3" "0" "0.951" "1.053" "1.115" "0.998" "1.101" "0.963" "1.067" "1.068" "0.795" "109.5" "104.2" "115.3" "122.1" "109.3" "120.5" "105.5" "116.9" "117.0" "87.0" "" "" "" "" "" "" "" "" "" "" "98.9" "80.4" "89.2" "82.2" "91.1" "102.9" "89.5" "84.6" "78.9" "87.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703778072310238355" "False" "High" "IsMasterProtein" "Q9Y6I3" "Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2" "0.000" "False" "23.205" "9" "4" "5" "4" "576" "60.3" "4.83" "16.98" "4" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01417" "29924" "ENSG00000063245" "EPN1" "hsa:29924; Q86ST3; Q9HA18; Q9Y6I3" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "5" "0" "1.196" "0.938" "1.068" "0.963" "1.023" "1.049" "0.847" "0.900" "1.148" "128.6" "153.7" "120.7" "137.3" "123.8" "131.6" "134.8" "108.9" "115.7" "147.5" "" "" "" "" "" "" "" "" "" "" "116.0" "118.6" "93.3" "92.4" "103.2" "112.3" "114.4" "78.8" "78.0" "147.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491360545906137157" "False" "High" "IsMasterProtein" "P54920" "Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3" "0.000" "False" "23.202" "21" "6" "12" "6" "295" "33.2" "5.36" "24.94" "6" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf14938" "8775" "ENSG00000105402" "NAPA" "A8K879; hsa:8775; P54920; Q96IK3; Q9BVJ3" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Golgi Associated Vesicle Biogenesis; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic; COPII-mediated vesicle transport" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling" "8" "0" "0.996" "1.143" "1.134" "0.950" "1.114" "1.044" "1.033" "1.262" "0.783" "381.4" "380.0" "435.9" "432.6" "362.2" "425.0" "398.3" "393.9" "481.2" "298.6" "" "" "" "" "" "" "" "" "" "" "344.3" "293.1" "337.1" "291.3" "302.2" "362.8" "337.9" "285.0" "324.6" "298.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7534759113121094513" "False" "High" "IsMasterProtein" "Q9Y3D9" "Small ribosomal subunit protein mS23 OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "0.000" "False" "23.195" "33" "6" "6" "6" "190" "21.8" "8.90" "21.10" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.031" "0.960" "1.016" "1.111" "0.867" "1.068" "1.006" "0.884" "1.345" "550.9" "568.2" "529.0" "559.9" "612.1" "477.6" "588.1" "554.3" "486.9" "741.0" "" "" "" "" "" "" "" "" "" "" "497.3" "438.3" "409.1" "377.0" "510.6" "407.6" "498.9" "401.2" "328.4" "741.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "76993751311903605" "False" "High" "IsMasterProtein" "Q9GZZ9" "Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1" "0.000" "False" "23.185" "12" "5" "10" "5" "404" "44.8" "4.84" "31.45" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00899" "79876" "ENSG00000081307" "UBA5" "A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.987" "0.865" "0.828" "0.980" "0.837" "0.967" "1.033" "0.843" "0.725" "783.2" "773.0" "677.5" "648.8" "767.9" "655.6" "757.5" "808.7" "660.5" "568.2" "" "" "" "" "" "" "" "" "" "" "706.9" "596.3" "524.0" "436.9" "640.5" "559.6" "642.6" "585.3" "445.5" "568.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "988734972597675031" "False" "High" "IsMasterProtein" "P01833" "Polymeric immunoglobulin receptor OS=Homo sapiens OX=9606 GN=PIGR PE=1 SV=4" "0.000" "False" "23.174" "4" "2" "4" "2" "764" "83.2" "5.74" "14.27" "2" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07686" "5284" "ENSG00000162896" "PIGR" "hsa:5284; P01833; Q68D81; Q8IZY7" "Neutrophil degranulation" "" "1" "0" "1.068" "1.049" "1.036" "1.047" "1.007" "1.179" "1.254" "1.073" "0.655" "275.3" "294.1" "288.8" "285.2" "288.4" "277.3" "324.5" "345.4" "295.6" "180.4" "" "" "" "" "" "" "" "" "" "" "248.5" "226.9" "223.4" "192.0" "240.5" "236.7" "275.3" "250.0" "199.4" "180.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926750901402698685" "False" "High" "IsMasterProtein" "Q9UKG1" "DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1" "0.000" "False" "23.162" "10" "7" "11" "7" "709" "79.6" "5.41" "28.95" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00640, Pf16746" "26060" "ENSG00000157500" "APPL1" "hsa:26060; Q9P2B9; Q9UKG1" "Caspase activation via Dependence Receptors in the absence of ligand" "Follicle stimulating hormone (FSH) signaling pathway; Chromosomal and microsatellite instability in colorectal cancer" "3" "0" "0.931" "1.074" "1.007" "1.011" "1.036" "1.060" "1.003" "0.984" "1.568" "742.3" "691.1" "797.0" "747.5" "750.2" "769.0" "786.7" "744.5" "730.4" "1163.9" "" "" "" "" "" "" "" "" "" "" "670.1" "533.1" "616.4" "503.4" "625.8" "656.4" "667.3" "538.8" "492.6" "1163.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097595206598813277" "False" "High" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "0.000" "False" "23.161" "21" "6" "10" "4" "282" "31.3" "9.83" "29.12" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "1" "1.060" "1.256" "0.993" "1.090" "1.257" "1.159" "1.088" "1.236" "0.865" "602.6" "638.9" "757.0" "598.2" "656.7" "757.2" "698.2" "655.9" "744.8" "521.0" "" "" "" "" "" "" "" "" "" "" "543.9" "492.8" "585.5" "402.8" "547.8" "646.2" "592.2" "474.7" "502.3" "521.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2633610480889665575" "False" "High" "IsMasterProtein" "O75608" "Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1" "0.000" "False" "23.111" "14" "3" "9" "3" "230" "24.7" "6.77" "30.95" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "10434" "ENSG00000120992" "LYPLA1" "hsa:10434; O43202; O75608; Q9UQF9" "RAS processing; eNOS activation" "" "2" "0" "1.058" "0.979" "1.041" "0.989" "1.046" "0.947" "1.027" "1.020" "0.675" "744.5" "787.6" "729.2" "775.3" "736.5" "779.1" "705.3" "764.9" "759.3" "502.3" "" "" "" "" "" "" "" "" "" "" "672.1" "607.5" "564.0" "522.1" "614.3" "665.0" "598.3" "553.5" "512.1" "502.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450891647387080638" "False" "High" "IsMasterProtein" "Q9BUL8" "Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1" "0.000" "False" "23.090" "19" "4" "6" "4" "212" "24.7" "8.19" "17.39" "4" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06840, Pf20929" "11235" "ENSG00000114209" "PDCD10" "A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8" "" "" "0" "0" "0.960" "0.889" "1.081" "0.955" "0.984" "1.032" "0.998" "1.001" "0.845" "367.8" "353.0" "326.8" "397.5" "351.1" "362.0" "379.4" "366.9" "368.3" "310.9" "" "" "" "" "" "" "" "" "" "" "332.0" "272.3" "252.8" "267.7" "292.9" "309.0" "321.9" "265.6" "248.4" "310.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5945011317712517661" "False" "High" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "0.000" "False" "23.082" "22" "4" "8" "4" "234" "25.9" "7.43" "25.86" "4" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "63" "0" "1.008" "0.937" "0.993" "0.962" "1.098" "0.961" "0.899" "1.127" "0.764" "188.8" "190.2" "176.9" "187.4" "181.6" "207.3" "181.4" "169.7" "212.8" "144.2" "" "" "" "" "" "" "" "" "" "" "170.4" "146.7" "136.8" "126.2" "151.5" "177.0" "153.8" "122.8" "143.5" "144.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321925279742634811" "False" "High" "IsMasterProtein" "Q9Y6Y8" "SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1" "0.000" "False" "23.066" "5" "5" "6" "5" "1000" "111.0" "5.54" "23.38" "5" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "11196" "ENSG00000107651" "SEC23IP" "D3DRD2; hsa:11196; Q8IXH5; Q9BUK5; Q9Y6Y8" "COPII-mediated vesicle transport" "" "1" "0" "0.919" "1.049" "0.887" "0.876" "1.025" "0.913" "0.892" "1.057" "1.876" "376.0" "345.5" "394.5" "333.4" "329.3" "385.3" "343.3" "335.5" "397.4" "705.4" "" "" "" "" "" "" "" "" "" "" "339.4" "266.5" "305.1" "224.5" "274.7" "328.8" "291.3" "242.8" "268.1" "705.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551730055028160476" "False" "High" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "0.000" "False" "23.061" "23" "5" "9" "3" "225" "25.5" "9.72" "28.04" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA Splicing - Major Pathway" "mRNA processing; Ciliary landscape" "3" "0" "1.033" "0.924" "0.946" "1.035" "0.930" "1.042" "0.974" "0.926" "0.910" "332.8" "343.6" "307.6" "314.8" "344.5" "309.4" "346.9" "324.0" "308.1" "302.8" "" "" "" "" "" "" "" "" "" "" "300.4" "265.1" "237.9" "212.0" "287.4" "264.1" "294.3" "234.5" "207.8" "302.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "212659989141045460" "False" "High" "IsMasterProtein" "P78356" "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1" "0.000" "False" "23.051" "14" "5" "8" "2" "416" "47.3" "7.33" "24.89" "5" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf01504" "8396" "ENSG00000276293; ENSG00000277292" "PIP4K2B" "hsa:8396; P78356; Q5U0E8; Q8TBP2" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton; 17q12 copy number variation syndrome" "6" "0" "0.961" "0.813" "1.024" "0.957" "0.843" "0.891" "0.938" "0.935" "0.920" "313.3" "301.2" "254.8" "320.7" "299.8" "264.2" "279.1" "293.8" "292.9" "288.3" "" "" "" "" "" "" "" "" "" "" "282.8" "232.3" "197.0" "216.0" "250.0" "225.5" "236.8" "212.6" "197.6" "288.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631999146533429965" "False" "High" "IsMasterProtein" "Q02878" "Large ribosomal subunit protein eL6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "0.000" "False" "23.016" "15" "5" "11" "5" "288" "32.7" "10.58" "33.26" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.929" "1.067" "0.989" "0.932" "1.012" "1.005" "1.024" "1.094" "0.301" "424.9" "394.6" "453.2" "420.1" "395.8" "429.8" "426.9" "435.3" "464.9" "127.8" "" "" "" "" "" "" "" "" "" "" "383.6" "304.4" "350.5" "282.9" "330.2" "366.8" "362.1" "315.0" "313.6" "127.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7071014728097244949" "False" "High" "IsMasterProtein" "Q9BW27" "Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1" "0.000" "False" "23.016" "6" "4" "4" "4" "656" "75.0" "5.55" "15.03" "4" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07575" "79902" "ENSG00000125450" "NUP85" "B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1" "Transport of Mature mRNA derived from an Intron-Containing Transcript; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "1.128" "0.813" "1.226" "1.248" "0.933" "1.183" "1.095" "0.862" "1.012" "235.6" "265.9" "191.6" "288.9" "294.0" "219.9" "278.8" "258.1" "203.0" "238.4" "" "" "" "" "" "" "" "" "" "" "212.7" "205.1" "148.2" "194.6" "245.2" "187.7" "236.5" "186.8" "136.9" "238.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5842118922115640430" "False" "High" "IsMasterProtein" "P36405" "ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2" "0.000" "False" "23.010" "20" "4" "7" "4" "182" "20.4" "7.24" "22.63" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "403" "ENSG00000138175" "ARL3" "B2R6C7; hsa:403; P36405; Q53X83; Q5JSM2" "Trafficking of myristoylated proteins to the cilium" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "5" "0" "1.079" "0.949" "1.096" "1.025" "0.940" "1.103" "1.063" "0.894" "0.658" "512.6" "552.9" "486.7" "561.8" "525.3" "481.7" "565.6" "544.7" "458.0" "337.3" "" "" "" "" "" "" "" "" "" "" "462.7" "426.5" "376.4" "378.3" "438.2" "411.2" "479.8" "394.2" "308.9" "337.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271910638518906992" "False" "High" "IsMasterProtein" "Q92552" "Small ribosomal subunit protein mS27 OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "0.000" "False" "22.994" "15" "5" "5" "5" "414" "47.6" "6.18" "18.93" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.940" "0.891" "1.027" "0.985" "0.867" "0.985" "1.007" "0.932" "0.872" "418.6" "393.6" "373.0" "429.9" "412.2" "362.9" "412.2" "421.7" "390.0" "365.1" "" "" "" "" "" "" "" "" "" "" "377.9" "303.6" "288.5" "289.5" "343.8" "309.8" "349.6" "305.2" "263.1" "365.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363881983208351205" "False" "High" "IsMasterProtein" "Q15438" "Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1" "0.000" "False" "22.968" "16" "6" "6" "6" "398" "46.4" "5.54" "20.86" "6" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9267" "ENSG00000108669" "CYTH1" "A6NFW7; B7Z1T4; hsa:9267; Q15438; Q9P123; Q9P124" "Intra-Golgi traffic" "2q37 copy number variation syndrome" "2" "0" "1.021" "0.847" "1.049" "1.024" "0.948" "0.954" "0.954" "0.941" "0.965" "351.8" "359.2" "298.1" "369.0" "360.3" "333.7" "335.6" "335.6" "331.2" "339.4" "" "" "" "" "" "" "" "" "" "" "317.6" "277.1" "230.5" "248.5" "300.6" "284.8" "284.7" "242.9" "223.4" "339.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991774416485678648" "False" "High" "IsMasterProtein" "P51948" "CDK-activating kinase assembly factor MAT1 OS=Homo sapiens OX=9606 GN=MNAT1 PE=1 SV=1" "0.000" "False" "22.945" "14" "5" "7" "5" "309" "35.8" "6.09" "21.14" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf06391, Pf17121" "4331" "ENSG00000020426" "MNAT1" "G3V1U8; hsa:4331; P51948; Q15817; Q6ICQ7" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "38" "0" "1.111" "0.848" "1.196" "1.063" "0.935" "1.039" "1.029" "1.013" "0.916" "483.5" "537.4" "410.1" "578.3" "514.0" "452.3" "502.1" "497.7" "489.7" "442.9" "" "" "" "" "" "" "" "" "" "" "436.5" "414.5" "317.2" "389.4" "428.7" "386.1" "426.0" "360.2" "330.3" "442.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5802267777781672264" "False" "High" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "0.000" "False" "22.939" "16" "3" "7" "3" "181" "21.2" "7.49" "25.86" "3" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "G alpha (i) signalling events" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "4" "0" "1.038" "0.924" "1.095" "1.057" "1.021" "1.160" "1.054" "0.916" "0.948" "294.1" "305.2" "271.7" "322.0" "311.0" "300.4" "341.3" "310.1" "269.5" "278.9" "" "" "" "" "" "" "" "" "" "" "265.5" "235.4" "210.2" "216.8" "259.4" "256.4" "289.5" "224.4" "181.8" "278.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3324031393637842436" "False" "High" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "0.000" "False" "22.882" "42" "4" "9" "4" "86" "10.1" "7.97" "27.64" "4" "other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "1.029" "1.179" "0.989" "1.046" "1.016" "1.101" "1.071" "1.060" "0.727" "392.4" "403.7" "462.8" "388.2" "410.5" "398.7" "432.0" "420.2" "415.9" "285.3" "" "" "" "" "" "" "" "" "" "" "354.2" "311.4" "357.9" "261.4" "342.4" "340.3" "366.5" "304.1" "280.5" "285.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1425618486899947959" "False" "High" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "0.000" "False" "22.876" "24" "4" "6" "4" "204" "23.4" "5.49" "16.25" "4" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "1.057" "1.015" "1.038" "1.034" "0.937" "1.122" "1.205" "0.903" "0.681" "203.7" "215.3" "206.8" "211.5" "210.5" "190.8" "228.5" "245.3" "184.0" "138.8" "" "" "" "" "" "" "" "" "" "" "183.8" "166.1" "159.9" "142.4" "175.6" "162.9" "193.8" "177.6" "124.1" "138.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3338411764392514561" "False" "High" "IsMasterProtein" "P45954" "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1" "0.000" "False" "22.876" "11" "4" "6" "4" "432" "47.5" "6.99" "16.15" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "36" "ENSG00000196177" "ACADSB" "B4DQ51; hsa:36; P45954; Q5SQN6; Q96CX7" "Branched-chain amino acid catabolism; Mitochondrial protein degradation" "Valproic acid pathway" "3" "0" "0.992" "0.718" "0.721" "0.926" "0.957" "0.935" "1.019" "0.721" "0.782" "62.8" "62.3" "45.1" "45.2" "58.1" "60.1" "58.7" "64.0" "45.3" "49.1" "" "" "" "" "" "" "" "" "" "" "56.7" "48.0" "34.8" "30.5" "48.5" "51.3" "49.8" "46.3" "30.5" "49.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908270249902800016" "False" "High" "IsMasterProtein" "P35573" "Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3" "0.000" "False" "22.846" "5" "7" "7" "7" "1532" "174.7" "6.76" "19.58" "7" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06202, Pf14699, Pf14701, Pf14702" "178" "ENSG00000162688" "AGL" "A6NCX7; A6NEK2; D3DT51; hsa:178; P35573; P78354; P78544; Q59H92; Q6AZ90; Q9UF08" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "Glycogen synthesis and degradation" "3" "0" "1.063" "0.900" "1.078" "0.941" "0.911" "1.187" "0.982" "0.998" "1.243" "199.9" "212.5" "179.9" "215.5" "188.0" "182.1" "237.1" "196.4" "199.4" "248.3" "" "" "" "" "" "" "" "" "" "" "180.4" "163.9" "139.1" "145.1" "156.9" "155.4" "201.2" "142.1" "134.5" "248.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "317033728722267888" "False" "High" "IsMasterProtein" "P34913" "Bifunctional epoxide hydrolase 2 OS=Homo sapiens OX=9606 GN=EPHX2 PE=1 SV=2" "0.000" "False" "22.781" "12" "6" "6" "6" "555" "62.6" "6.28" "17.93" "6" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00561, Pf00702" "2053" "ENSG00000120915" "EPHX2" "B2Z3B1; B3KTU8; B3KUA0; G3V134; hsa:2053; J3KPH7; P34913; Q16764; Q9HBJ1; Q9HBJ2" "Peroxisomal protein import; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET); Biosynthesis of maresins" "Eicosanoid metabolism via cytochrome P450 monooxygenases pathway; Familial hyperlipidemia type 2; ALA oxylipin metabolism; Linoleic acid oxylipin metabolism; Docosahexaenoic acid oxylipin metabolism; Arachidonic acid (AA, ARA) oxylipin metabolism; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "12" "0" "1.084" "1.074" "0.978" "0.958" "0.897" "0.896" "0.909" "1.005" "0.735" "206.3" "223.7" "221.6" "201.7" "197.5" "185.0" "184.9" "187.6" "207.3" "151.5" "" "" "" "" "" "" "" "" "" "" "186.2" "172.5" "171.4" "135.8" "164.8" "157.9" "156.9" "135.7" "139.8" "151.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6512701136026714686" "False" "High" "IsMasterProtein" "O95379" "Tumor necrosis factor alpha-induced protein 8 OS=Homo sapiens OX=9606 GN=TNFAIP8 PE=1 SV=1" "0.000" "False" "22.723" "34" "6" "8" "6" "198" "23.0" "7.93" "21.19" "6" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05527" "25816" "ENSG00000145779" "TNFAIP8" "B3KMH1; B3KMI2; B7Z713; hsa:25816; O95379; Q9P1Q1; Q9UER5; Q9UP47" "PI Metabolism" "" "1" "0" "1.067" "1.044" "1.042" "0.986" "1.122" "1.068" "0.910" "1.081" "0.973" "115.5" "123.3" "120.7" "120.4" "113.9" "129.7" "123.4" "105.1" "124.9" "112.5" "" "" "" "" "" "" "" "" "" "" "104.3" "95.1" "93.3" "81.1" "95.0" "110.7" "104.7" "76.1" "84.2" "112.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8303204193391828869" "False" "High" "IsMasterProtein" "Q8WUI4" "Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2" "0.000" "False" "22.706" "5" "5" "5" "5" "952" "102.9" "7.58" "15.86" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "51564" "ENSG00000061273" "HDAC7" "B3KY08; B4DWI0; B4E0Q5; hsa:51564; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q8WUI4; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7" "SUMOylation of DNA damage response and repair proteins; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Gastrin signaling pathway" "13" "0" "1.060" "0.849" "1.048" "0.970" "0.910" "0.934" "1.070" "0.939" "0.770" "234.8" "248.9" "199.5" "246.2" "227.8" "213.7" "219.4" "251.3" "220.5" "180.8" "" "" "" "" "" "" "" "" "" "" "212.0" "192.0" "154.3" "165.8" "190.0" "182.4" "186.1" "181.9" "148.7" "180.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3728877322360888626" "False" "High" "IsMasterProtein" "P62854" "Small ribosomal subunit protein eS26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3" "0.000" "False" "22.696" "21" "2" "7" "2" "115" "13.0" "11.00" "25.38" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01283" "6231" "ENSG00000197728" "RPS26" "hsa:6231; P02383; P62854; P70394; Q06722; Q3MHD8; Q6IRY4" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.237" "0.779" "0.793" "0.986" "0.916" "1.019" "1.080" "0.914" "0.621" "46.4" "57.4" "36.1" "36.8" "45.8" "42.5" "47.3" "50.1" "42.4" "28.8" "" "" "" "" "" "" "" "" "" "" "41.9" "44.3" "27.9" "24.8" "38.2" "36.3" "40.1" "36.3" "28.6" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "672780113730382771" "False" "High" "IsMasterProtein" "Q99952" "Tyrosine-protein phosphatase non-receptor type 18 OS=Homo sapiens OX=9606 GN=PTPN18 PE=1 SV=2" "0.000" "False" "22.691" "9" "3" "6" "3" "460" "50.5" "8.25" "25.96" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26469" "ENSG00000072135" "PTPN18" "B4E1E6; hsa:26469; Q53P42; Q99952" "Downregulation of ERBB2 signaling; Interleukin-37 signaling" "B cell receptor signaling pathway" "3" "0" "0.909" "0.952" "0.995" "0.977" "0.932" "0.937" "1.050" "0.930" "0.777" "267.7" "243.5" "254.9" "266.3" "261.5" "249.4" "250.8" "281.0" "248.9" "208.0" "" "" "" "" "" "" "" "" "" "" "241.7" "187.8" "197.1" "179.3" "218.2" "212.9" "212.7" "203.4" "167.9" "208.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8217852517475646555" "False" "High" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "0.000" "False" "22.673" "7" "6" "6" "6" "944" "103.0" "6.07" "18.22" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "0.833" "0.850" "0.959" "0.869" "0.747" "0.883" "0.627" "0.858" "5.765" "392.4" "326.8" "333.5" "376.4" "340.9" "293.1" "346.6" "246.0" "336.8" "2262.0" "" "" "" "" "" "" "" "" "" "" "354.2" "252.0" "257.9" "253.5" "284.4" "250.1" "294.0" "178.1" "227.2" "2262.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8170052287552769839" "False" "High" "IsMasterProtein" "Q13905" "Rap guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=RAPGEF1 PE=1 SV=3" "0.000" "False" "22.651" "6" "6" "8" "6" "1077" "120.5" "5.92" "27.08" "6" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00617, Pf00618" "2889" "ENSG00000107263" "RAPGEF1" "hsa:2889; Q13905; Q5JUE4; Q68DL3; Q8IV73" "MET activates RAP1 and RAC1; RAC3 GTPase cycle; Regulation of signaling by CBL; Downstream signal transduction; Erythropoietin activates RAS; Frs2-mediated activation" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MET in type 1 papillary renal cell carcinoma; Insulin signaling; Interferon type I signaling pathways" "17" "0" "0.977" "1.055" "0.902" "0.916" "1.154" "0.948" "0.801" "1.163" "2.249" "271.7" "265.5" "286.5" "245.1" "248.7" "313.4" "257.5" "217.5" "316.0" "610.9" "" "" "" "" "" "" "" "" "" "" "245.2" "204.8" "221.6" "165.0" "207.5" "267.5" "218.4" "157.4" "213.1" "610.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5279606303405418158" "False" "High" "IsMasterProtein" "Q9H2K8" "Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2" "0.000" "False" "22.647" "7" "7" "11" "6" "898" "105.3" "7.30" "27.32" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "51347" "ENSG00000135090" "TAOK3" "hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "MAPK signaling pathway" "4" "0" "1.041" "0.900" "1.177" "1.142" "0.934" "0.990" "0.901" "0.907" "0.914" "109.2" "113.7" "98.3" "128.6" "124.8" "102.1" "108.1" "98.4" "99.1" "99.8" "" "" "" "" "" "" "" "" "" "" "98.6" "87.7" "76.0" "86.6" "104.1" "87.1" "91.7" "71.2" "66.8" "99.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1767684544015944843" "False" "High" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "0.000" "False" "22.637" "24" "6" "9" "6" "240" "24.6" "11.19" "22.72" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.015" "1.203" "1.094" "1.093" "1.055" "2.106" "1.072" "1.219" "0.881" "424.1" "430.5" "510.4" "464.2" "463.5" "447.5" "893.1" "454.6" "517.0" "373.6" "" "" "" "" "" "" "" "" "" "" "382.8" "332.0" "394.8" "312.6" "386.6" "382.0" "757.6" "329.0" "348.7" "373.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042042739323188079" "False" "High" "IsMasterProtein" "Q9UQ35" "Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2" "0.000" "False" "22.609" "3" "8" "8" "8" "2752" "299.4" "12.06" "24.00" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08312" "23524" "ENSG00000167978" "SRRM2" "A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40" "mRNA Splicing - Major Pathway" "" "1" "0" "0.931" "1.111" "0.983" "1.111" "1.330" "0.956" "1.040" "1.154" "1.537" "308.2" "286.8" "342.4" "303.0" "342.4" "410.0" "294.7" "320.4" "355.6" "473.5" "" "" "" "" "" "" "" "" "" "" "278.2" "221.2" "264.8" "204.0" "285.6" "349.9" "250.0" "231.9" "239.9" "473.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502404100025205194" "False" "High" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "0.000" "False" "22.586" "7" "4" "6" "4" "592" "67.5" "4.60" "20.76" "4" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "15q11q13 copy number variation" "9" "0" "0.958" "0.991" "1.048" "0.971" "0.954" "0.892" "0.885" "0.873" "1.770" "583.0" "558.6" "578.0" "611.0" "566.3" "556.5" "519.9" "515.9" "508.9" "1032.2" "" "" "" "" "" "" "" "" "" "" "526.3" "430.9" "447.1" "411.4" "472.4" "475.0" "441.0" "373.3" "343.3" "1032.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238479499176412626" "False" "High" "IsMasterProtein" "O60828" "Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1" "0.000" "False" "22.563" "26" "6" "7" "6" "265" "30.5" "6.33" "24.28" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "10084" "ENSG00000102103; ENSG00000292208" "PQBP1" "C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4" "mRNA Splicing - Major Pathway" "" "1" "0" "1.075" "0.989" "0.841" "0.946" "0.998" "1.010" "1.291" "0.856" "0.628" "582.9" "626.6" "576.7" "490.1" "551.6" "581.5" "588.9" "752.6" "499.0" "366.1" "" "" "" "" "" "" "" "" "" "" "526.1" "483.3" "446.0" "330.0" "460.1" "496.3" "499.6" "544.6" "336.6" "366.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7918100123629271451" "False" "High" "IsMasterProtein" "Q9NWV4" "CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1" "0.000" "False" "22.553" "36" "5" "5" "5" "160" "18.0" "5.01" "17.76" "5" "" "" "other molecular function" "Pf05907" "54987" "ENSG00000162384" "CZIB" "hsa:54987; Q9NWV4" "" "" "0" "0" "1.013" "0.985" "1.008" "0.944" "1.030" "0.993" "1.015" "1.005" "0.759" "572.5" "580.2" "564.2" "577.4" "540.3" "589.8" "568.4" "581.0" "575.5" "434.4" "" "" "" "" "" "" "" "" "" "" "516.8" "447.5" "436.3" "388.8" "450.7" "503.4" "482.2" "420.4" "388.2" "434.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1418350428187629844" "False" "High" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "0.000" "False" "22.534" "48" "4" "4" "4" "99" "10.9" "9.57" "15.07" "4" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "6" "0" "0.990" "1.254" "1.020" "0.992" "1.295" "1.023" "0.884" "1.383" "0.548" "117.0" "115.8" "146.7" "119.3" "116.1" "151.5" "119.6" "103.4" "161.8" "64.2" "" "" "" "" "" "" "" "" "" "" "105.6" "89.3" "113.4" "80.4" "96.8" "129.3" "101.5" "74.9" "109.1" "64.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846658872779087383" "False" "High" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "0.000" "False" "22.528" "19" "5" "7" "5" "334" "36.6" "8.27" "18.12" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Neddylation; RMTs methylate histone arginines; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis" "Pleural mesothelioma; Kleefstra syndrome" "10" "0" "0.921" "1.092" "1.013" "0.922" "1.004" "1.207" "1.043" "0.907" "1.147" "54.4" "50.1" "59.4" "55.1" "50.1" "54.6" "65.6" "56.7" "49.3" "62.4" "" "" "" "" "" "" "" "" "" "" "49.1" "38.6" "45.9" "37.1" "41.8" "46.6" "55.7" "41.0" "33.2" "62.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3353134017530951509" "False" "High" "IsMasterProtein" "Q9Y5K5" "Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5 PE=1 SV=3" "0.000" "False" "22.511" "19" "6" "8" "6" "329" "37.6" "5.33" "23.02" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01088, Pf18031" "51377" "ENSG00000116750" "UCHL5" "hsa:51377; Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2; Q9Y5K5" "UCH proteinases; Downregulation of TGF-beta receptor signaling" "TGF-beta signaling pathway" "3" "0" "1.142" "0.942" "1.122" "1.062" "1.021" "1.089" "0.831" "1.090" "4.432" "125.0" "142.7" "117.8" "140.3" "132.8" "127.7" "136.2" "103.9" "136.3" "554.2" "" "" "" "" "" "" "" "" "" "" "112.9" "110.1" "91.1" "94.4" "110.8" "109.0" "115.5" "75.2" "91.9" "554.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2438255133986472284" "False" "High" "IsMasterProtein" "Q9H8H0" "Nucleolar protein 11 OS=Homo sapiens OX=9606 GN=NOL11 PE=1 SV=1" "0.000" "False" "22.506" "9" "7" "7" "7" "719" "81.1" "6.07" "19.52" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf08168, Pf20998" "25926" "ENSG00000130935" "NOL11" "B7Z5V9; hsa:25926; Q7L5S1; Q9H8H0; Q9UG18" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.052" "0.887" "0.959" "1.009" "0.871" "0.959" "0.996" "1.012" "0.414" "282.9" "297.8" "251.1" "271.4" "285.6" "246.4" "271.3" "281.7" "286.4" "117.1" "" "" "" "" "" "" "" "" "" "" "255.4" "229.7" "194.2" "182.7" "238.2" "210.3" "230.1" "203.9" "193.2" "117.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065211085214910630" "False" "High" "IsMasterProtein" "Q96EL3" "Large ribosomal subunit protein mL53 OS=Homo sapiens OX=9606 GN=MRPL53 PE=1 SV=1" "0.000" "False" "22.477" "34" "3" "4" "3" "112" "12.1" "8.76" "15.43" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10780" "116540" "ENSG00000204822" "MRPL53" "hsa:116540; Q96EL3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.054" "1.131" "0.994" "1.070" "1.241" "1.321" "1.189" "1.123" "1.146" "157.2" "165.8" "177.9" "156.2" "168.3" "195.1" "207.6" "186.9" "176.5" "180.1" "" "" "" "" "" "" "" "" "" "" "141.9" "127.9" "137.6" "105.2" "140.4" "166.5" "176.1" "135.3" "119.1" "180.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190260410723795831" "False" "High" "IsMasterProtein" "Q14257" "Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1" "0.000" "False" "22.430" "18" "4" "5" "4" "317" "36.9" "4.40" "14.56" "4" "" "ER/Golgi;nucleus" "other molecular function" "Pf13202, Pf13499" "5955" "ENSG00000117906" "RCN2" "A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8" "" "" "0" "0" "1.135" "0.926" "0.907" "0.881" "0.933" "0.904" "0.862" "0.977" "1.823" "117.3" "133.1" "108.6" "106.3" "103.3" "109.5" "106.1" "101.0" "114.5" "213.7" "" "" "" "" "" "" "" "" "" "" "105.9" "102.7" "84.0" "71.6" "86.2" "93.4" "90.0" "73.1" "77.3" "213.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-115181160460478952" "False" "High" "IsMasterProtein" "P35754" "Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2" "0.000" "False" "22.406" "30" "2" "3" "2" "106" "11.8" "8.09" "12.96" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00462" "2745" "ENSG00000173221" "GLRX" "B2R4L2; hsa:2745; P35754; Q3KQS1; Q6ICT1" "Interconversion of nucleotide di- and triphosphates" "One-carbon metabolism" "2" "0" "1.207" "0.985" "1.145" "1.440" "1.237" "1.409" "1.392" "1.130" "0.763" "24.6" "29.7" "24.3" "28.2" "35.5" "30.5" "34.7" "34.3" "27.8" "18.8" "" "" "" "" "" "" "" "" "" "" "22.2" "22.9" "18.8" "19.0" "29.6" "26.0" "29.4" "24.8" "18.8" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-92542688516821267" "False" "High" "IsMasterProtein" "Q14699" "Raftlin OS=Homo sapiens OX=9606 GN=RFTN1 PE=1 SV=4" "0.000" "False" "22.390" "10" "6" "11" "6" "578" "63.1" "5.67" "30.38" "6" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf15250" "23180" "ENSG00000131378" "RFTN1" "hsa:23180; Q0D2G0; Q14699; Q496Y2; Q4QQI7; Q5JB48; Q7Z7P2" "" "" "0" "0" "0.967" "0.944" "1.066" "0.999" "0.808" "1.038" "1.027" "0.932" "0.701" "347.1" "335.9" "327.7" "369.9" "346.9" "280.6" "360.3" "356.5" "323.5" "243.5" "" "" "" "" "" "" "" "" "" "" "313.4" "259.1" "253.4" "249.1" "289.4" "239.5" "305.7" "258.0" "218.2" "243.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3062212909163771863" "False" "High" "IsMasterProtein" "P19838" "Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2" "0.000" "False" "22.377" "5" "4" "4" "4" "968" "105.3" "5.40" "14.17" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4790" "ENSG00000109320" "NFKB1" "A8K5Y5; B3KVE8; hsa:4790; P19838; Q68D84; Q86V43; Q8N4X7; Q9NZC0" "Neutrophil degranulation; FCERI mediated NF-kB activation; Downstream TCR signaling; Transcriptional regulation of white adipocyte differentiation; Activation of NF-kappaB in B cells; HCMV Early Events; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; PDGF pathway; Apoptosis; T cell receptor and co-stimulatory signaling; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Selenium metabolism and selenoproteins; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; Oxidative stress response; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; Nonalcoholic fatty liver disease; LTF danger signal response pathway; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Canonical NF-kB pathway; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Aspirin and miRNAs; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; FGF23 signaling in hypophosphatemic rickets and related disorders; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; RAS and bradykinin pathways in COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Prostaglandin signaling; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Inclusion body myositis; Alzheimer's disease; Th17 cell differentiation pathway; Lung pathology of COVID-19; Ulcerative colitis signaling; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Inflammatory bowel disease signaling; Role of ROS in COVID-19 endothelial dysfunction; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; TROP2 regulatory signaling; Autophagy in pancreatic ductal adenocarcinoma; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; 10q22q23 copy number variation; IL-19 signaling pathway; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; Notch signaling pathway; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway" "151" "0" "0.905" "0.973" "1.073" "0.986" "0.900" "1.024" "0.652" "1.042" "6.074" "119.3" "107.9" "116.0" "128.0" "117.6" "107.3" "122.1" "77.8" "124.3" "724.3" "" "" "" "" "" "" "" "" "" "" "107.6" "83.2" "89.7" "86.2" "98.1" "91.6" "103.5" "56.3" "83.8" "724.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494116660910275017" "False" "High" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "0.000" "False" "22.373" "13" "5" "9" "5" "394" "44.4" "5.40" "29.29" "5" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "" "2" "0" "1.003" "0.951" "0.963" "1.003" "1.018" "1.052" "0.964" "1.029" "0.949" "415.5" "416.7" "395.3" "400.2" "416.8" "422.7" "437.2" "400.5" "427.7" "394.2" "" "" "" "" "" "" "" "" "" "" "375.0" "321.4" "305.7" "269.5" "347.7" "360.8" "370.8" "289.9" "288.4" "394.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6687870354662644574" "False" "High" "IsMasterProtein" "Q8N3D4" "EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2" "0.000" "False" "22.348" "3" "4" "5" "4" "1523" "161.8" "4.83" "15.77" "4" "" "other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "254102" "ENSG00000173442" "EHBP1L1" "hsa:254102; Q8N3D4; Q8TB89; Q9H7M7" "" "" "0" "0" "1.064" "1.363" "1.196" "1.102" "1.291" "1.104" "0.959" "1.290" "2.230" "246.1" "261.7" "335.4" "294.4" "271.2" "317.7" "271.6" "236.0" "317.5" "548.7" "" "" "" "" "" "" "" "" "" "" "222.1" "201.9" "259.4" "198.3" "226.2" "271.2" "230.4" "170.8" "214.2" "548.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492167490634941437" "False" "High" "IsMasterProtein" "P49914" "5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2" "0.000" "False" "22.335" "23" "4" "8" "4" "203" "23.2" "7.88" "24.54" "4" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01812" "10588" "ENSG00000136371" "MTHFS" "H3BQ75; hsa:10588; P49914" "Metabolism of folate and pterines" "Folate metabolism; One-carbon metabolism; Disorders of folate metabolism and transport" "4" "0" "1.031" "0.869" "0.911" "1.054" "0.954" "0.953" "1.067" "0.954" "0.922" "380.2" "391.8" "330.4" "346.3" "400.7" "362.8" "362.3" "405.6" "362.5" "350.4" "" "" "" "" "" "" "" "" "" "" "343.2" "302.2" "255.6" "233.2" "334.2" "309.7" "307.4" "293.5" "244.5" "350.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459643991948160099" "False" "High" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "0.000" "False" "22.275" "6" "8" "9" "8" "1034" "117.1" "7.87" "25.27" "8" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "1.040" "1.171" "1.050" "1.040" "1.111" "0.986" "0.982" "1.187" "0.889" "284.5" "296.0" "333.2" "298.8" "295.8" "316.2" "280.4" "279.3" "337.8" "252.9" "" "" "" "" "" "" "" "" "" "" "256.8" "228.3" "257.7" "201.2" "246.7" "269.9" "237.9" "202.2" "227.8" "252.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5241124612822470915" "False" "High" "IsMasterProtein" "P36639" "Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4" "0.000" "False" "22.263" "26" "3" "7" "3" "156" "17.9" "5.08" "25.26" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "4521" "ENSG00000106268" "NUDT1" "A4D205; hsa:4521; P36639; Q6LES7; Q6P0Y6; Q7Z7N6; Q8IV95; Q9UBM0; Q9UBM9" "" "" "0" "0" "1.058" "0.814" "0.946" "0.923" "0.787" "0.920" "1.054" "0.853" "1.331" "163.0" "172.5" "132.7" "154.2" "150.5" "128.2" "149.9" "171.8" "139.1" "217.0" "" "" "" "" "" "" "" "" "" "" "147.1" "133.1" "102.7" "103.9" "125.5" "109.4" "127.2" "124.4" "93.8" "217.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179525910857735181" "False" "High" "IsMasterProtein" "P49590" "Histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1" "0.000" "False" "22.258" "11" "6" "8" "2" "506" "56.9" "8.24" "23.55" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf03129, Pf13393" "23438" "ENSG00000112855" "HARS2" "B4DDY8; hsa:23438; P49590" "Mitochondrial tRNA aminoacylation" "Primary ovarian insufficiency" "2" "0" "1.232" "0.769" "0.943" "1.251" "0.816" "1.105" "1.155" "0.815" "0.767" "129.3" "159.3" "99.5" "121.9" "161.8" "105.5" "142.9" "149.4" "105.4" "99.2" "" "" "" "" "" "" "" "" "" "" "116.7" "122.9" "76.9" "82.1" "135.0" "90.0" "121.2" "108.1" "71.1" "99.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3678214923131327318" "False" "High" "IsMasterProtein" "Q96RQ3" "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC1 PE=1 SV=3" "0.000" "False" "22.238" "6" "4" "6" "4" "725" "80.4" "7.78" "19.66" "4" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786" "56922" "ENSG00000078070" "MCCC1" "hsa:56922; Q59ES4; Q96RQ3; Q9H959; Q9NS97" "Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "Amino acid metabolism" "4" "0" "1.041" "0.869" "1.090" "1.164" "0.925" "1.098" "1.124" "0.944" "0.854" "318.1" "331.0" "276.4" "346.7" "370.3" "294.4" "349.1" "357.5" "300.3" "271.5" "" "" "" "" "" "" "" "" "" "" "287.1" "255.3" "213.8" "233.5" "308.9" "251.2" "296.1" "258.7" "202.5" "271.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3257917255703740656" "False" "High" "IsMasterProtein" "Q14181" "DNA polymerase alpha subunit B OS=Homo sapiens OX=9606 GN=POLA2 PE=1 SV=2" "0.000" "False" "22.230" "9" "6" "6" "6" "598" "65.9" "5.24" "18.75" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus" "nucleic acid binding activity" "Pf04042, Pf08418" "23649" "ENSG00000014138" "POLA2" "B4DNB4; hsa:23649; Q14181; Q9BPV3" "Defective pyroptosis; Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "12" "0" "1.073" "0.762" "0.973" "1.013" "0.848" "0.864" "0.795" "0.958" "2.489" "201.1" "215.8" "153.2" "195.7" "203.8" "170.5" "173.8" "159.8" "192.6" "500.6" "" "" "" "" "" "" "" "" "" "" "181.6" "166.5" "118.5" "131.8" "170.0" "145.5" "147.4" "115.7" "129.9" "500.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6442873191784740439" "False" "High" "IsMasterProtein" "Q9BXW7" "Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1" "0.000" "False" "22.218" "14" "5" "9" "5" "423" "46.3" "8.13" "30.48" "5" "other metabolic processes" "mitochondrion" "" "Pf13344" "27440" "ENSG00000069998" "HDHD5" "B2RCK5; Q9BXW7; Q9BXW8; Q9NWA8; Q9NX41" "" "" "0" "0" "0.991" "0.861" "0.947" "0.811" "0.873" "0.802" "1.064" "0.823" "1.015" "334.8" "331.8" "288.1" "316.9" "271.5" "292.4" "268.6" "356.2" "275.4" "339.7" "" "" "" "" "" "" "" "" "" "" "302.2" "255.9" "222.8" "213.4" "226.5" "249.6" "227.9" "257.8" "185.8" "339.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1552754402547085825" "False" "High" "IsMasterProtein" "Q5MIZ7" "Serine/threonine-protein phosphatase 4 regulatory subunit 3B OS=Homo sapiens OX=9606 GN=PPP4R3B PE=1 SV=2" "0.000" "False" "22.217" "6" "5" "8" "1" "849" "97.4" "4.96" "23.77" "5" "other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "57223" "ENSG00000275052" "PPP4R3B" "hsa:57223; Q5MIZ7; Q6P9B0; Q86XB8; Q9BQJ0; Q9BRK2; Q9H913; Q9P2G0" "" "16p11.2 proximal deletion syndrome" "1" "0" "1.067" "1.174" "1.170" "1.058" "1.216" "1.139" "0.870" "1.211" "2.881" "50.5" "53.9" "59.3" "59.0" "53.4" "61.4" "57.5" "43.9" "61.1" "145.4" "" "" "" "" "" "" "" "" "" "" "45.5" "41.5" "45.8" "39.7" "44.5" "52.4" "48.7" "31.8" "41.2" "145.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604354164667528726" "False" "High" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "0.000" "False" "22.207" "9" "6" "8" "6" "683" "78.5" "6.87" "24.88" "6" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "Signaling by CSF1 (M-CSF) in myeloid cells; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "4" "0" "0.973" "0.885" "0.836" "1.012" "0.816" "1.002" "1.014" "0.909" "0.632" "604.5" "587.9" "534.9" "505.4" "611.6" "493.2" "605.8" "613.2" "549.4" "381.9" "" "" "" "" "" "" "" "" "" "" "545.7" "453.5" "413.7" "340.3" "510.2" "421.0" "513.9" "443.8" "370.6" "381.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981355964815445657" "False" "High" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "0.000" "False" "22.205" "5" "4" "4" "4" "737" "80.9" "5.83" "13.87" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "" "3" "0" "0.962" "0.820" "1.015" "0.917" "0.847" "1.028" "0.981" "0.822" "0.883" "434.6" "418.1" "356.4" "441.1" "398.6" "368.1" "446.8" "426.2" "357.2" "383.8" "" "" "" "" "" "" "" "" "" "" "392.3" "322.5" "275.6" "297.0" "332.5" "314.2" "379.0" "308.5" "240.9" "383.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-381937601164646059" "False" "High" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "0.000" "False" "22.188" "15" "5" "7" "5" "358" "40.6" "5.94" "20.45" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "7" "0" "1.143" "1.084" "1.180" "1.037" "1.106" "1.417" "1.180" "0.932" "0.627" "47.2" "53.9" "51.1" "55.7" "48.9" "52.2" "66.8" "55.7" "44.0" "29.6" "" "" "" "" "" "" "" "" "" "" "42.6" "41.6" "39.5" "37.5" "40.8" "44.5" "56.7" "40.3" "29.7" "29.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6265096555801149049" "False" "High" "IsMasterProtein" "P06132" "Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2" "0.000" "False" "22.182" "11" "4" "6" "4" "367" "40.8" "6.14" "21.76" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01208" "7389" "ENSG00000126088" "UROD" "A8K762; hsa:7389; P06132; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "0.971" "1.045" "1.096" "0.882" "1.043" "0.892" "0.948" "1.113" "0.754" "311.4" "302.5" "325.5" "341.4" "274.7" "325.0" "277.7" "295.3" "346.6" "234.9" "" "" "" "" "" "" "" "" "" "" "281.1" "233.4" "251.8" "229.9" "229.2" "277.4" "235.6" "213.7" "233.8" "234.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5034217840069919209" "False" "High" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "0.000" "False" "22.177" "20" "5" "7" "5" "258" "29.0" "5.81" "23.63" "5" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Intra-Golgi traffic; Neutrophil degranulation" "Ciliary landscape; 22q11.2 copy number variation syndrome" "4" "0" "1.055" "0.832" "1.032" "1.066" "0.820" "1.010" "1.016" "0.849" "0.811" "280.4" "295.8" "233.3" "289.3" "299.0" "229.8" "283.1" "284.9" "238.2" "227.4" "" "" "" "" "" "" "" "" "" "" "253.1" "228.1" "180.4" "194.8" "249.4" "196.1" "240.2" "206.2" "160.7" "227.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276103228213200498" "False" "High" "IsMasterProtein" "P62308" "Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1" "0.000" "False" "22.157" "25" "2" "11" "2" "76" "8.5" "8.88" "25.67" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6637" "ENSG00000143977" "SNRPG" "D6W5G6; hsa:6637; P62308; Q15357; Q6IB86" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "0.996" "1.074" "0.741" "1.011" "0.983" "1.062" "1.011" "0.836" "0.809" "572.6" "570.2" "615.3" "424.4" "578.7" "563.2" "608.2" "578.8" "478.8" "463.0" "" "" "" "" "" "" "" "" "" "" "516.9" "439.8" "475.9" "285.8" "482.8" "480.7" "515.9" "418.8" "322.9" "463.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3143517004493314389" "False" "High" "IsMasterProtein" "Q01970" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens OX=9606 GN=PLCB3 PE=1 SV=2" "0.000" "False" "22.156" "5" "6" "10" "6" "1234" "138.7" "5.90" "29.69" "6" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5331" "ENSG00000149782" "PLCB3" "A5PKZ6; G5E960; hsa:5331; Q01970; Q8N1A4" "G alpha (q) signalling events; Synthesis of IP3 and IP4 in the cytosol; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; PLC beta mediated events; Acetylcholine regulates insulin secretion" "Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells" "26" "0" "0.981" "1.035" "0.964" "0.961" "0.920" "0.990" "0.987" "1.047" "0.974" "559.7" "549.3" "579.3" "539.8" "538.1" "515.2" "554.4" "552.4" "586.2" "544.9" "" "" "" "" "" "" "" "" "" "" "505.3" "423.7" "448.1" "363.5" "448.9" "439.7" "470.3" "399.8" "395.4" "544.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377093586219491132" "False" "High" "IsMasterProtein" "Q5VW36" "Focadhesin OS=Homo sapiens OX=9606 GN=FOCAD PE=1 SV=2" "0.000" "False" "22.148" "4" "7" "7" "7" "1801" "199.9" "6.62" "20.59" "7" "other biological processes" "cytosol;other cell component" "" "Pf11229, Pf12530" "54914" "ENSG00000188352" "FOCAD" "D3DRJ9; hsa:54914; Q5VW36; Q6ZME1; Q8IZG0; Q96JM8; Q96MS9; Q9BVF3; Q9NX87" "" "" "0" "0" "0.975" "0.912" "0.886" "0.984" "0.870" "0.966" "1.043" "0.802" "0.892" "221.2" "215.7" "201.7" "196.1" "217.7" "192.5" "213.6" "230.8" "177.4" "197.4" "" "" "" "" "" "" "" "" "" "" "199.7" "166.4" "156.0" "132.0" "181.6" "164.3" "181.2" "167.0" "119.7" "197.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3425744660855709231" "False" "High" "IsMasterProtein" "O60568" "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1" "0.000" "False" "22.146" "7" "5" "6" "5" "738" "84.7" "6.05" "20.61" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf03171" "8985" "ENSG00000106397" "PLOD3" "B2R6W6; hsa:8985; O60568; Q540C3" "Collagen biosynthesis and modifying enzymes" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "3" "0" "1.022" "0.977" "1.024" "1.077" "0.983" "1.020" "0.948" "1.059" "0.973" "405.4" "414.5" "396.1" "415.3" "436.6" "398.4" "413.5" "384.5" "429.5" "394.3" "" "" "" "" "" "" "" "" "" "" "366.0" "319.7" "306.3" "279.7" "364.2" "340.0" "350.8" "278.2" "289.7" "394.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6568070672358433938" "False" "High" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=3" "0.000" "False" "22.141" "5" "7" "9" "7" "1268" "141.4" "6.87" "23.03" "7" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "HDL clearance" "2q37 copy number variation syndrome" "2" "0" "0.968" "0.856" "0.948" "1.004" "0.879" "0.962" "0.502" "0.849" "7.957" "240.0" "232.4" "205.4" "227.5" "240.8" "210.9" "230.9" "120.5" "203.6" "1909.3" "" "" "" "" "" "" "" "" "" "" "216.6" "179.2" "158.8" "153.2" "200.9" "180.0" "195.9" "87.2" "137.4" "1909.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2093622632730469128" "False" "High" "IsMasterProtein" "Q15418" "Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens OX=9606 GN=RPS6KA1 PE=1 SV=2" "0.000" "False" "22.110" "9" "7" "8" "1" "735" "82.7" "7.83" "22.88" "7" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6195" "ENSG00000117676; ENSG00000281877" "RPS6KA1" "A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4; hsa:6195; Q15418; Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2" "CREB phosphorylation; Senescence-Associated Secretory Phenotype (SASP); RSK activation; ERK/MAPK targets; Gastrin-CREB signalling pathway via PKC and MAPK; Recycling pathway of L1" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; TYROBP causal network in microglia; Thermogenesis; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map" "26" "0" "0.985" "0.952" "1.066" "1.324" "0.971" "1.095" "0.768" "1.011" "1.940" "53.3" "52.5" "50.7" "56.8" "70.5" "51.7" "58.3" "40.9" "53.8" "103.3" "" "" "" "" "" "" "" "" "" "" "48.1" "40.5" "39.2" "38.2" "58.8" "44.1" "49.5" "29.6" "36.3" "103.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1135638411849566769" "False" "High" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "0.000" "False" "22.105" "10" "5" "5" "5" "490" "54.9" "10.13" "16.36" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "1.012" "0.981" "0.936" "1.048" "0.898" "1.032" "0.948" "0.902" "0.625" "407.0" "411.9" "399.3" "380.9" "426.5" "365.3" "419.9" "385.7" "367.3" "254.3" "" "" "" "" "" "" "" "" "" "" "367.4" "317.7" "308.8" "256.5" "355.8" "311.8" "356.2" "279.1" "247.7" "254.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2375108519350628678" "False" "High" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "0.000" "False" "22.063" "12" "6" "10" "4" "482" "55.1" "5.48" "28.77" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Potential therapeutics for SARS; Estrogen-dependent gene expression; Formation of the beta-catenin:TCF transactivating complex; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Nuclear events stimulated by ALK signaling in cancer; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; TGF-beta signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome; Effect of progerin on genes involved in progeria; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "56" "2" "1.068" "1.188" "0.846" "0.983" "1.169" "0.930" "0.967" "1.132" "1.692" "593.1" "633.5" "704.7" "501.9" "582.7" "693.4" "551.7" "573.7" "671.1" "1003.7" "" "" "" "" "" "" "" "" "" "" "535.3" "488.7" "545.1" "338.0" "486.1" "591.8" "468.0" "415.2" "452.7" "1003.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8162183631045646946" "False" "High" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "0.000" "False" "22.047" "9" "3" "7" "1" "375" "41.6" "7.74" "21.79" "3" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "FGFR2 alternative splicing" "" "1" "0" "1.135" "1.088" "1.050" "0.998" "1.099" "1.074" "0.945" "1.058" "1.001" "91.9" "104.3" "100.0" "96.5" "91.7" "101.0" "98.7" "86.9" "97.3" "92.0" "" "" "" "" "" "" "" "" "" "" "83.0" "80.5" "77.3" "65.0" "76.5" "86.2" "83.7" "62.9" "65.6" "92.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5301300435928167882" "False" "High" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "0.000" "False" "22.042" "18" "4" "8" "3" "286" "32.9" "5.85" "22.51" "4" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108137657648573585" "False" "High" "IsMasterProtein" "O95571" "Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2" "0.000" "False" "22.030" "18" "4" "5" "4" "254" "27.9" "6.83" "16.87" "4" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00753" "23474" "ENSG00000105755" "ETHE1" "hsa:23474; O95571; Q96HR0; Q9H001" "Sulfide oxidation to sulfate" "" "1" "0" "1.016" "1.080" "1.117" "1.002" "1.103" "0.920" "0.992" "1.053" "0.673" "118.6" "120.5" "128.1" "132.5" "118.9" "130.8" "109.1" "117.7" "125.0" "79.9" "" "" "" "" "" "" "" "" "" "" "107.1" "92.9" "99.1" "89.2" "99.2" "111.7" "92.5" "85.2" "84.3" "79.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6438294564185077030" "False" "High" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "0.000" "False" "22.002" "17" "5" "8" "5" "284" "33.3" "9.31" "21.78" "5" "other biological processes" "plasma membrane;other membranes;mitochondrion" "" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "0" "1.127" "1.061" "1.041" "1.233" "1.098" "1.028" "1.167" "1.063" "0.678" "228.4" "257.4" "242.3" "237.7" "281.6" "250.9" "234.8" "266.5" "242.8" "155.0" "" "" "" "" "" "" "" "" "" "" "206.2" "198.6" "187.4" "160.1" "234.9" "214.1" "199.2" "192.8" "163.8" "155.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235464357787345308" "False" "High" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "0.000" "False" "21.988" "28" "4" "15" "4" "118" "13.1" "4.88" "46.19" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Regulation of expression of SLITs and ROBOs; Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Evasion by RSV of host interferon responses; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "22" "0" "0.966" "0.924" "0.942" "0.951" "0.974" "0.991" "1.033" "0.949" "0.825" "1466.0" "1415.7" "1355.1" "1381.5" "1394.8" "1428.2" "1453.1" "1513.6" "1391.1" "1209.4" "" "" "" "" "" "" "" "" "" "" "1323.3" "1092.0" "1048.1" "930.3" "1163.5" "1218.9" "1232.6" "1095.4" "938.3" "1209.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594801350968766228" "False" "High" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "0.000" "False" "21.975" "13" "4" "6" "4" "396" "45.4" "8.91" "19.62" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "Initiation of Nuclear Envelope (NE) Reformation; Nuclear Envelope Breakdown" "" "2" "0" "1.207" "0.863" "1.071" "1.216" "0.808" "1.104" "1.035" "0.725" "2.016" "153.9" "185.8" "132.8" "164.9" "187.1" "124.3" "169.9" "159.4" "111.6" "310.4" "" "" "" "" "" "" "" "" "" "" "138.9" "143.3" "102.7" "111.1" "156.1" "106.1" "144.1" "115.3" "75.3" "310.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857445100061984594" "False" "High" "IsMasterProtein" "Q8WVY7" "Ubiquitin-like domain-containing CTD phosphatase 1 OS=Homo sapiens OX=9606 GN=UBLCP1 PE=1 SV=2" "0.000" "False" "21.951" "14" "5" "8" "5" "318" "36.8" "6.46" "23.89" "5" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00240, Pf03031" "134510" "ENSG00000164332" "UBLCP1" "D3DQJ7; hsa:134510; Q8WVY7; Q96DK5" "" "" "0" "0" "0.903" "1.055" "0.920" "0.905" "1.041" "0.942" "0.893" "1.068" "1.591" "649.8" "586.7" "685.6" "597.9" "588.2" "676.7" "612.1" "580.4" "694.2" "1033.8" "" "" "" "" "" "" "" "" "" "" "586.6" "452.6" "530.3" "402.6" "490.6" "577.5" "519.3" "420.0" "468.2" "1033.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713269859164182683" "False" "High" "IsMasterProtein" "P08567" "Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3" "0.000" "False" "21.946" "10" "3" "7" "3" "350" "40.1" "8.28" "23.31" "3" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00169, Pf00610" "5341" "ENSG00000115956" "PLEK" "B2R9E8; hsa:5341; P08567; Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81" "Platelet degranulation" "Serotonin and anxiety-related events; TYROBP causal network in microglia; Serotonin and anxiety" "4" "0" "1.049" "0.836" "0.959" "1.037" "0.888" "0.996" "1.017" "0.896" "1.189" "461.9" "484.4" "386.4" "443.2" "478.9" "410.4" "459.9" "469.9" "414.0" "549.3" "" "" "" "" "" "" "" "" "" "" "417.0" "373.6" "298.8" "298.4" "399.5" "350.3" "390.1" "340.1" "279.2" "549.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1124967282390941354" "False" "High" "IsMasterProtein" "Q9HB90" "Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1" "0.000" "False" "21.911" "11" "3" "6" "3" "399" "44.2" "5.10" "15.40" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "64121" "ENSG00000116954" "RRAGC" "hsa:64121; Q9H202; Q9H8Q8; Q9HB90" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "Target of rapamycin signaling; Orexin receptor pathway; 2q37 copy number variation syndrome" "10" "0" "1.214" "0.974" "1.346" "1.142" "0.996" "1.161" "1.246" "1.168" "0.856" "346.1" "420.3" "337.2" "466.0" "395.4" "344.8" "401.9" "431.3" "404.2" "296.3" "" "" "" "" "" "" "" "" "" "" "312.4" "324.2" "260.8" "313.8" "329.8" "294.3" "340.9" "312.1" "272.7" "296.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594484432885072185" "False" "High" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "0.000" "False" "21.895" "17" "5" "6" "5" "272" "31.4" "5.91" "20.67" "5" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "" "Ciliary landscape" "1" "0" "0.997" "0.905" "0.950" "0.914" "0.958" "0.974" "0.899" "0.908" "1.167" "260.5" "259.6" "235.7" "247.4" "238.1" "249.6" "253.7" "234.2" "236.6" "304.1" "" "" "" "" "" "" "" "" "" "" "235.1" "200.3" "182.3" "166.6" "198.6" "213.0" "215.2" "169.5" "159.6" "304.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4889317708786741676" "False" "High" "IsMasterProtein" "Q96AT1" "Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2" "0.000" "False" "21.867" "28" "4" "6" "4" "154" "17.5" "6.11" "19.65" "4" "" "" "" "Pf15377" "57456" "ENSG00000163807; ENSG00000281665" "KIAA1143" "A8K0I4; hsa:57456; Q96AT1; Q96HJ8; Q9ULS7" "" "" "0" "0" "0.925" "0.920" "0.966" "0.935" "0.864" "0.961" "1.067" "0.851" "0.671" "361.1" "334.0" "332.3" "348.8" "337.8" "311.9" "346.9" "385.2" "307.1" "242.1" "" "" "" "" "" "" "" "" "" "" "325.9" "257.6" "257.0" "234.9" "281.7" "266.2" "294.2" "278.8" "207.2" "242.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2043411241930693309" "False" "High" "IsMasterProtein" "Q96JM3" "Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2" "0.000" "False" "21.859" "7" "6" "8" "6" "812" "89.0" "8.44" "25.31" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "" "283489" "ENSG00000198824" "CHAMP1" "B3KU06; hsa:283489; Q6P181; Q8NC88; Q96JM3; Q9BST0" "" "" "0" "0" "0.987" "1.111" "1.104" "0.994" "1.123" "1.108" "1.026" "1.122" "1.588" "182.1" "179.7" "202.3" "200.9" "180.9" "204.5" "201.8" "186.8" "204.2" "289.2" "" "" "" "" "" "" "" "" "" "" "164.4" "138.6" "156.5" "135.3" "150.9" "174.5" "171.2" "135.2" "137.7" "289.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662139928789152118" "False" "High" "IsMasterProtein" "Q8WYJ6" "Septin-1 OS=Homo sapiens OX=9606 GN=SEPTIN1 PE=1 SV=3" "0.000" "False" "21.858" "15" "5" "6" "5" "372" "42.4" "5.80" "19.36" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "1731" "ENSG00000180096" "SEPTIN1" "B4DVE6; hsa:1731; Q658T1; Q8NEZ1; Q8WYJ6; Q96EL4; Q9H285" "" "" "0" "0" "0.980" "0.845" "0.949" "1.013" "0.914" "0.977" "0.995" "0.952" "0.863" "441.9" "433.3" "373.4" "419.3" "447.5" "404.0" "431.8" "439.8" "420.7" "381.3" "" "" "" "" "" "" "" "" "" "" "398.9" "334.2" "288.8" "282.4" "373.3" "344.9" "366.3" "318.3" "283.8" "381.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762449723745155897" "False" "High" "IsMasterProtein" "Q9H5V9" "STING ER exit protein OS=Homo sapiens OX=9606 GN=STEEP1 PE=1 SV=1" "0.000" "False" "21.821" "29" "6" "6" "6" "222" "25.6" "8.73" "20.98" "6" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "mRNA Splicing - Major Pathway" "" "1" "0" "0.994" "1.012" "0.992" "1.018" "0.935" "0.984" "1.084" "1.050" "1.009" "331.8" "329.8" "335.7" "329.3" "337.9" "310.2" "326.4" "359.7" "348.5" "334.9" "" "" "" "" "" "" "" "" "" "" "299.5" "254.4" "259.6" "221.7" "281.8" "264.8" "276.9" "260.3" "235.0" "334.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "61926280635528933" "False" "High" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "0.000" "False" "21.797" "3" "4" "4" "4" "1362" "152.1" "9.19" "16.78" "4" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "Potential therapeutics for SARS" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "3" "0" "1.059" "1.434" "1.081" "1.237" "1.419" "1.153" "0.985" "1.403" "2.756" "256.8" "271.9" "368.2" "277.5" "317.7" "364.5" "296.0" "253.1" "360.3" "707.8" "" "" "" "" "" "" "" "" "" "" "231.8" "209.7" "284.8" "186.9" "265.0" "311.1" "251.1" "183.2" "243.0" "707.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4228584982071455131" "False" "High" "IsMasterProtein" "Q92769" "Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2" "0.000" "False" "21.790" "14" "6" "9" "4" "488" "55.3" "5.91" "25.18" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "3066" "ENSG00000196591" "HDAC2" "B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769" "Factors involved in megakaryocyte development and platelet production; Regulation of MECP2 expression and activity; Regulation of TP53 Activity through Acetylation; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; STAT3 nuclear events downstream of ALK signaling; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels" "Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in progeria; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2819715853452011200" "False" "High" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "0.000" "False" "21.740" "30" "5" "9" "5" "166" "19.2" "7.34" "31.43" "5" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "mRNA Splicing - Major Pathway" "" "1" "0" "1.011" "1.073" "0.910" "0.954" "1.070" "0.945" "1.117" "1.057" "0.669" "868.7" "878.3" "931.7" "790.1" "828.3" "929.5" "821.0" "970.3" "917.9" "581.5" "" "" "" "" "" "" "" "" "" "" "784.1" "677.5" "720.6" "532.0" "690.9" "793.4" "696.4" "702.2" "619.1" "581.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697682766688933342" "False" "High" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "0.000" "False" "21.736" "24" "4" "6" "4" "169" "19.4" "8.81" "19.18" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "" "Metapathway biotransformation Phase I and II" "1" "0" "0.872" "1.002" "0.996" "0.917" "0.918" "0.930" "1.002" "0.969" "0.746" "419.5" "366.0" "420.5" "417.7" "384.6" "385.3" "390.2" "420.2" "406.5" "312.8" "" "" "" "" "" "" "" "" "" "" "378.7" "282.3" "325.2" "281.3" "320.8" "328.8" "331.0" "304.1" "274.2" "312.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819481250379265452" "False" "High" "IsMasterProtein" "Q5JWF2" "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2" "0.000" "False" "21.734" "4" "3" "7" "2" "1037" "111.0" "5.03" "18.95" "3" "cell adhesion;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2778" "ENSG00000087460" "GNAS" "A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state" "Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling" "29" "0" "1.004" "0.919" "1.163" "1.024" "0.903" "1.047" "0.986" "1.046" "0.973" "141.0" "141.5" "129.7" "164.1" "144.5" "127.3" "147.6" "139.0" "147.5" "137.3" "" "" "" "" "" "" "" "" "" "" "127.3" "109.2" "100.3" "110.5" "120.5" "108.7" "125.2" "100.6" "99.5" "137.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2703376622299265366" "False" "High" "IsMasterProtein" "Q9UKF6" "Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1" "0.000" "False" "21.731" "9" "6" "6" "6" "684" "77.4" "5.60" "19.24" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07521, Pf10996, Pf11718, Pf16661" "51692" "ENSG00000119203" "CPSF3" "hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "0.907" "0.890" "1.013" "1.045" "0.875" "0.978" "0.973" "0.837" "1.641" "207.1" "187.9" "184.3" "209.8" "216.3" "181.1" "202.6" "201.5" "173.3" "339.9" "" "" "" "" "" "" "" "" "" "" "186.9" "144.9" "142.6" "141.3" "180.4" "154.6" "171.9" "145.8" "116.9" "339.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387736998001173674" "False" "High" "IsMasterProtein" "Q969T4" "Ubiquitin-conjugating enzyme E2 E3 OS=Homo sapiens OX=9606 GN=UBE2E3 PE=1 SV=1" "0.000" "False" "21.731" "19" "3" "7" "2" "207" "22.9" "7.18" "17.87" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "10477" "ENSG00000170035" "UBE2E3" "B2RAD6; D3DPG3; hsa:10477; Q5U0R7; Q7Z4W4; Q969T4" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "7q11.23 copy number variation syndrome" "3" "0" "0.903" "0.846" "1.079" "1.047" "1.106" "1.070" "0.760" "0.872" "1.003" "49.1" "44.4" "41.6" "53.0" "51.4" "54.3" "52.6" "37.3" "42.8" "49.3" "" "" "" "" "" "" "" "" "" "" "44.4" "34.2" "32.2" "35.7" "42.9" "46.4" "44.6" "27.0" "28.9" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5035986382802710418" "False" "High" "IsMasterProtein" "Q9NUB1" "Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Homo sapiens OX=9606 GN=ACSS1 PE=1 SV=2" "0.000" "False" "21.714" "10" "7" "8" "7" "689" "74.8" "7.11" "23.98" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193, Pf16177" "84532" "ENSG00000154930" "ACSS1" "B3KXL2; B4DJZ3; D3DW48; F5H6F4; F8W7Y1; hsa:84532; Q5TF42; Q8IV99; Q8N234; Q96JI1; Q96JX6; Q9NU28; Q9NUB1" "Ethanol oxidation" "Sterol regulatory element-binding proteins (SREBP) signaling; Amino acid metabolism; Statin inhibition of cholesterol production; Familial hyperlipidemia type 4" "5" "0" "1.091" "0.989" "0.980" "1.069" "0.989" "1.079" "1.061" "1.081" "0.952" "455.3" "496.7" "450.4" "446.1" "486.6" "450.1" "491.3" "482.8" "492.3" "433.5" "" "" "" "" "" "" "" "" "" "" "410.9" "383.1" "348.3" "300.4" "405.9" "384.1" "416.7" "349.4" "332.0" "433.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507762156530799771" "False" "High" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "0.000" "False" "21.708" "9" "3" "8" "3" "478" "50.7" "9.10" "29.37" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "1.043" "1.078" "1.121" "1.068" "1.129" "1.175" "1.127" "1.105" "0.842" "259.5" "270.6" "279.6" "290.8" "277.2" "293.0" "304.8" "292.3" "286.8" "218.4" "" "" "" "" "" "" "" "" "" "" "234.2" "208.7" "216.2" "195.8" "231.2" "250.1" "258.6" "211.6" "193.4" "218.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-313217822058437387" "False" "High" "IsMasterProtein" "P55789" "FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens OX=9606 GN=GFER PE=1 SV=2" "0.000" "False" "21.702" "24" "4" "5" "4" "205" "23.4" "7.62" "15.01" "4" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf04777" "2671" "ENSG00000127554; ENSG00000291944" "GFER" "hsa:2671; P55789; Q53YM6; Q8TAH6; Q9H290; Q9UK40" "Mitochondrial protein import" "" "1" "0" "1.017" "1.003" "1.235" "1.049" "1.031" "1.331" "1.167" "1.041" "0.811" "36.3" "36.9" "36.4" "44.8" "38.1" "37.4" "48.3" "42.4" "37.8" "29.4" "" "" "" "" "" "" "" "" "" "" "32.8" "28.5" "28.2" "30.2" "31.8" "31.9" "41.0" "30.7" "25.5" "29.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4643868144451564503" "False" "High" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "0.000" "False" "21.682" "27" "2" "10" "2" "113" "12.7" "7.44" "39.32" "2" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "2" "0" "1.039" "0.843" "0.924" "0.912" "0.881" "0.965" "1.045" "0.835" "0.659" "614.9" "638.7" "518.5" "568.3" "560.8" "542.0" "593.5" "642.9" "513.3" "405.0" "" "" "" "" "" "" "" "" "" "" "555.1" "492.7" "401.0" "382.7" "467.8" "462.6" "503.5" "465.2" "346.2" "405.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123043622142940735" "False" "High" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "0.000" "False" "21.681" "23" "4" "10" "4" "182" "20.7" "8.69" "26.74" "4" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Platelet degranulation" "Orexin receptor pathway" "2" "0" "1.006" "1.018" "0.877" "0.930" "0.974" "0.988" "1.022" "1.004" "0.672" "560.2" "563.5" "570.2" "491.5" "521.0" "545.8" "553.3" "572.4" "562.3" "376.5" "" "" "" "" "" "" "" "" "" "" "505.6" "434.6" "441.0" "331.0" "434.6" "465.8" "469.4" "414.3" "379.3" "376.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9165342661713370894" "False" "High" "IsMasterProtein" "Q969U7" "Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1" "0.000" "False" "21.662" "19" "5" "7" "5" "264" "29.4" "6.98" "22.51" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf09754" "56984" "ENSG00000128789" "PSMG2" "B0YJB3; hsa:56984; Q6IAH4; Q969U7; Q9NRV1; V9GYH7" "" "" "0" "0" "1.058" "1.005" "0.957" "1.070" "1.126" "1.066" "1.073" "0.908" "0.642" "360.2" "381.3" "362.0" "344.6" "385.4" "405.5" "384.1" "386.5" "327.2" "231.2" "" "" "" "" "" "" "" "" "" "" "325.2" "294.1" "280.0" "232.1" "321.5" "346.1" "325.8" "279.7" "220.7" "231.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8632288723347516488" "False" "High" "IsMasterProtein" "Q03013" "Glutathione S-transferase Mu 4 OS=Homo sapiens OX=9606 GN=GSTM4 PE=1 SV=3" "0.000" "False" "21.659" "27" "6" "8" "3" "218" "25.5" "5.90" "24.99" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00043, Pf02798" "2948" "ENSG00000168765" "GSTM4" "A8K765; hsa:2948; Q03013; Q05465; Q32NC1; Q4JNT8; Q6FH87" "Glutathione conjugation; Biosynthesis of maresin conjugates in tissue regeneration (MCTR)" "Nuclear receptors meta-pathway; NRF2 pathway; Metapathway biotransformation Phase I and II" "5" "3" "1.081" "0.878" "1.066" "1.135" "1.052" "0.950" "0.960" "1.049" "0.687" "319.7" "345.5" "280.8" "340.8" "362.8" "336.3" "303.7" "306.9" "335.2" "219.5" "" "" "" "" "" "" "" "" "" "" "288.6" "266.5" "217.2" "229.5" "302.7" "287.0" "257.7" "222.1" "226.1" "219.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1007819713485126010" "False" "High" "IsMasterProtein" "P83916" "Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1" "0.000" "False" "21.657" "22" "4" "6" "4" "185" "21.4" "4.93" "17.66" "4" "cell organization and biogenesis;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf01393" "10951" "ENSG00000108468" "CBX1" "hsa:10951; P23197; P83916" "HCMV Early Events" "Effect of progerin on genes involved in progeria" "2" "0" "1.124" "1.108" "1.327" "0.987" "1.169" "1.107" "0.985" "1.185" "0.917" "419.9" "472.1" "465.2" "557.0" "414.6" "490.9" "464.6" "413.5" "497.3" "385.1" "" "" "" "" "" "" "" "" "" "" "379.0" "364.1" "359.8" "375.1" "345.8" "419.0" "394.1" "299.3" "335.4" "385.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4536078631798452952" "False" "High" "IsMasterProtein" "Q6P582" "Mitotic-spindle organizing protein 2A OS=Homo sapiens OX=9606 GN=MZT2A PE=1 SV=2" "0.000" "False" "21.640" "27" "3" "4" "3" "158" "16.2" "9.64" "14.44" "3" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "653784" "ENSG00000173272" "MZT2A" "hsa:653784; Q3SWV8; Q6P582; Q8WVB2" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2q21.1 copy number variation syndrome" "3" "0" "1.037" "0.986" "1.471" "1.070" "1.178" "1.089" "1.162" "0.923" "1.078" "24.8" "25.7" "24.5" "36.5" "26.5" "29.2" "27.0" "28.8" "22.9" "26.8" "" "" "" "" "" "" "" "" "" "" "22.4" "19.9" "18.9" "24.6" "22.1" "24.9" "22.9" "20.9" "15.4" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5840066189523461680" "False" "High" "IsMasterProtein" "P22694" "cAMP-dependent protein kinase catalytic subunit beta OS=Homo sapiens OX=9606 GN=PRKACB PE=1 SV=2" "0.000" "False" "21.637" "14" "6" "9" "1" "351" "40.6" "8.78" "28.29" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5567" "ENSG00000142875" "PRKACB" "B1APG4; B4DKB0; B4E2Q1; hsa:5567; P22694; Q14VH1; Q59GC0; Q5BNE9; Q5BNF0; Q5BNF1; Q5BNF2; Q5BNF3; Q5CZ92; Q5T1K3; Q7Z3M1; Q8IYR5; Q8IZQ0; Q96B09" "FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "AMP-activated protein kinase signaling; Dopamine metabolism; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Chemokine signaling pathway; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "47" "2" "0.996" "1.147" "1.113" "0.977" "1.082" "1.078" "1.074" "1.210" "1.376" "391.9" "390.4" "449.6" "436.2" "382.8" "424.2" "422.3" "420.7" "474.3" "539.4" "" "" "" "" "" "" "" "" "" "" "353.8" "301.1" "347.7" "293.8" "319.3" "362.1" "358.2" "304.5" "319.9" "539.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531201272546720497" "False" "High" "IsMasterProtein" "P14854" "Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2" "0.000" "False" "21.633" "62" "5" "8" "5" "86" "10.2" "7.05" "24.66" "5" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02297" "1340" "ENSG00000126267" "COX6B1" "B2R5C9; hsa:1340; P14854; Q6IBL4" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "7" "0" "1.013" "1.022" "1.046" "0.989" "1.057" "0.971" "1.120" "1.063" "1.064" "934.1" "946.1" "954.9" "977.5" "923.4" "987.6" "907.0" "1046.2" "993.0" "993.5" "" "" "" "" "" "" "" "" "" "" "843.2" "729.7" "738.6" "658.2" "770.3" "842.9" "769.4" "757.1" "669.8" "993.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "568464796837822948" "False" "High" "IsMasterProtein" "O43823" "A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1" "0.000" "False" "21.559" "6" "4" "5" "4" "692" "76.1" "5.15" "18.65" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "10270" "ENSG00000105127" "AKAP8" "hsa:10270; O43823" "" "G protein signaling pathways" "1" "0" "1.091" "1.347" "1.143" "1.069" "1.248" "1.133" "1.103" "1.234" "2.042" "510.0" "556.2" "686.9" "582.7" "545.2" "636.4" "578.0" "562.6" "629.2" "1041.5" "" "" "" "" "" "" "" "" "" "" "460.3" "429.1" "531.3" "392.4" "454.8" "543.2" "490.3" "407.2" "424.4" "1041.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889177674351520658" "False" "High" "IsMasterProtein" "Q8ND24" "RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2" "0.000" "False" "21.521" "5" "3" "4" "3" "703" "77.6" "6.95" "15.40" "3" "" "" "other molecular function" "" "257160" "ENSG00000167257" "RNF214" "B2RUW0; B4DTD1; hsa:257160; Q8ND24" "" "" "0" "0" "0.963" "1.296" "1.109" "1.081" "1.267" "0.955" "0.965" "1.188" "2.242" "98.7" "95.0" "127.9" "109.4" "106.6" "125.0" "94.2" "95.2" "117.2" "221.2" "" "" "" "" "" "" "" "" "" "" "89.1" "73.3" "98.9" "73.7" "89.0" "106.7" "79.9" "68.9" "79.1" "221.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521793610303513807" "False" "High" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "0.000" "False" "21.456" "9" "7" "7" "6" "917" "102.3" "6.05" "13.70" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Glycolysis" "Clear cell renal cell carcinoma pathways; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "7" "0" "1.021" "1.149" "1.248" "1.071" "1.076" "0.936" "0.690" "1.023" "7.276" "137.9" "140.9" "158.5" "172.1" "147.8" "148.4" "129.1" "95.2" "141.1" "1003.5" "" "" "" "" "" "" "" "" "" "" "124.5" "108.7" "122.6" "115.9" "123.3" "126.7" "109.5" "68.9" "95.2" "1003.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651766820472939276" "False" "High" "IsMasterProtein" "Q12792" "Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3" "0.000" "False" "21.455" "13" "4" "5" "3" "350" "40.3" "6.96" "16.29" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "5756" "ENSG00000151239" "TWF1" "A8K5A8; B3KXS6; B4DLX9; hsa:5756; Q12792; Q59G07; Q5U0B1; Q6FHJ1; Q6FHL6; Q6NUK9; Q86XL6; Q8TCD3" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle" "" "3" "0" "0.927" "1.106" "1.101" "0.994" "1.058" "0.962" "1.056" "1.173" "0.824" "149.5" "138.5" "165.4" "164.6" "148.7" "158.2" "143.9" "157.9" "175.4" "123.2" "" "" "" "" "" "" "" "" "" "" "135.0" "106.9" "127.9" "110.9" "124.0" "135.0" "122.0" "114.3" "118.3" "123.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6273876737902892662" "False" "High" "IsMasterProtein" "P83876" "Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1" "0.000" "False" "21.439" "21" "3" "5" "3" "142" "16.8" "5.85" "14.57" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf02966" "10907" "ENSG00000141759" "TXNL4A" "B2RC18; hsa:10907; O14834; P83876" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.024" "0.867" "0.853" "0.932" "1.009" "0.921" "1.015" "0.888" "0.682" "106.1" "108.7" "92.0" "90.5" "98.9" "107.1" "97.8" "107.8" "94.2" "72.4" "" "" "" "" "" "" "" "" "" "" "95.8" "83.9" "71.1" "60.9" "82.5" "91.4" "83.0" "78.0" "63.5" "72.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "558828740565352174" "False" "High" "IsMasterProtein" "Q2VPK5" "Cytoplasmic tRNA 2-thiolation protein 2 OS=Homo sapiens OX=9606 GN=CTU2 PE=1 SV=1" "0.000" "False" "21.437" "11" "5" "6" "5" "515" "56.1" "6.32" "16.25" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf10288" "348180" "ENSG00000174177" "CTU2" "B2RXK0; hsa:348180; Q0P511; Q2VPK5; Q66K78; Q6P4C8; Q86SV4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.030" "1.018" "1.084" "1.081" "1.040" "0.990" "0.980" "1.182" "1.052" "184.0" "189.5" "187.3" "199.4" "198.8" "191.5" "182.1" "180.3" "217.6" "193.6" "" "" "" "" "" "" "" "" "" "" "166.1" "146.2" "144.9" "134.3" "165.8" "163.4" "154.5" "130.5" "146.7" "193.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9100750251972445181" "False" "High" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "0.000" "False" "21.432" "6" "9" "9" "9" "1478" "164.9" "5.22" "24.50" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "" "2" "0" "0.907" "1.286" "0.987" "0.894" "1.180" "0.845" "0.849" "1.246" "1.680" "463.6" "420.4" "596.3" "457.7" "414.3" "547.1" "391.8" "393.8" "577.6" "778.9" "" "" "" "" "" "" "" "" "" "" "418.5" "324.3" "461.2" "308.2" "345.6" "467.0" "332.4" "285.0" "389.6" "778.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4593935513655895610" "False" "High" "IsMasterProtein" "Q13614" "Myotubularin-related protein 2 OS=Homo sapiens OX=9606 GN=MTMR2 PE=1 SV=4" "0.000" "False" "21.415" "9" "5" "5" "5" "643" "73.3" "7.40" "16.76" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "8898" "ENSG00000087053" "MTMR2" "A6NN98; hsa:8898; Q13614; Q9UPS9" "Synthesis of PIPs at the ER membrane; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "Intracellular trafficking proteins involved in CMT neuropathy" "5" "0" "0.987" "0.991" "1.024" "0.996" "1.082" "1.030" "0.987" "1.103" "0.884" "295.4" "291.6" "292.8" "302.6" "294.2" "319.6" "304.2" "291.4" "325.8" "261.0" "" "" "" "" "" "" "" "" "" "" "266.6" "224.9" "226.5" "203.7" "245.4" "272.7" "258.1" "210.9" "219.8" "261.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6099589946817253427" "False" "High" "IsMasterProtein" "Q7Z417" "FMR1-interacting protein NUFIP2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "0.000" "False" "21.413" "8" "4" "4" "4" "695" "76.1" "8.70" "13.55" "4" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "1.090" "1.923" "0.994" "1.066" "1.575" "1.154" "1.404" "1.674" "1.082" "98.9" "107.8" "190.2" "98.3" "105.4" "155.8" "114.2" "138.9" "165.5" "107.1" "" "" "" "" "" "" "" "" "" "" "89.3" "83.2" "147.1" "66.2" "88.0" "133.0" "96.8" "100.5" "111.7" "107.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3997402182379015815" "False" "High" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "0.000" "False" "21.407" "13" "6" "6" "6" "548" "63.9" "6.05" "17.39" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "9" "0" "1.189" "0.957" "1.018" "1.281" "1.179" "0.810" "0.605" "0.786" "6.685" "36.3" "43.2" "34.8" "37.0" "46.5" "42.8" "29.4" "22.0" "28.6" "242.8" "" "" "" "" "" "" "" "" "" "" "32.8" "33.3" "26.9" "24.9" "38.8" "36.6" "25.0" "15.9" "19.3" "242.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6137891794897938593" "False" "High" "IsMasterProtein" "Q8NEF9" "Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1" "0.000" "False" "21.402" "14" "6" "6" "6" "429" "48.6" "9.58" "17.93" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09073" "153443" "ENSG00000151304" "SRFBP1" "hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2" "" "" "0" "0" "0.932" "1.704" "0.982" "0.957" "1.616" "0.981" "1.013" "1.560" "0.757" "61.4" "57.3" "104.7" "60.3" "58.8" "99.3" "60.3" "62.2" "95.9" "46.5" "" "" "" "" "" "" "" "" "" "" "55.5" "44.2" "81.0" "40.6" "49.1" "84.7" "51.1" "45.0" "64.7" "46.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3787459776374465912" "False" "High" "IsMasterProtein" "Q9Y5L0" "Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3" "0.000" "False" "21.378" "7" "7" "8" "7" "923" "104.1" "5.57" "21.55" "7" "transport" "other membranes;nucleus;other cell component" "other molecular function" "Pf08389" "23534" "ENSG00000064419" "TNPO3" "A4D1K9; C9IZM0; hsa:23534; Q6NUM1; Q96G71; Q96GU9; Q9Y3R2; Q9Y5L0" "" "" "0" "0" "1.020" "0.927" "1.103" "1.065" "1.041" "0.999" "0.968" "0.934" "1.117" "162.4" "165.7" "150.6" "179.1" "173.0" "169.2" "162.3" "157.3" "151.8" "181.5" "" "" "" "" "" "" "" "" "" "" "146.6" "127.8" "116.4" "120.6" "144.3" "144.4" "137.7" "113.8" "102.4" "181.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-10968856719763814" "False" "High" "IsMasterProtein" "P62081" "Small ribosomal subunit protein eS7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "0.000" "False" "21.359" "23" "5" "9" "5" "194" "22.1" "10.10" "21.15" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "0.938" "1.084" "0.901" "1.010" "1.025" "0.956" "1.010" "0.993" "0.577" "774.9" "726.6" "840.3" "697.8" "782.9" "794.5" "741.1" "782.5" "769.6" "447.1" "" "" "" "" "" "" "" "" "" "" "699.5" "560.5" "649.9" "469.9" "653.1" "678.1" "628.7" "566.3" "519.1" "447.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9020069583805455300" "False" "High" "IsMasterProtein" "O60234" "Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1" "0.000" "False" "21.333" "23" "3" "5" "2" "142" "16.8" "5.26" "17.16" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "9535" "ENSG00000130755; ENSG00000291873" "GMFG" "hsa:9535; O60234; Q6IB37" "Neutrophil degranulation" "" "1" "1" "1.059" "1.024" "1.227" "1.049" "1.069" "1.110" "1.046" "0.958" "1.008" "209.0" "221.2" "214.0" "256.4" "219.2" "223.5" "231.9" "218.7" "200.2" "210.7" "" "" "" "" "" "" "" "" "" "" "188.7" "170.7" "165.5" "172.7" "182.8" "190.8" "196.7" "158.3" "135.1" "210.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100821946699504428" "False" "High" "IsMasterProtein" "Q5QNW6" "Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3" "0.000" "False" "21.289" "35" "5" "13" "1" "126" "13.9" "10.32" "39.85" "5" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "440689" "ENSG00000203814" "H2BC18" "A8K0U9; B4DLA9; hsa:440689; Q5QNW6" "HCMV Late Events; HCMV Early Events; Ub-specific processing proteases; HDACs deacetylate histones; HATs acetylate histones" "" "5" "0" "0.971" "0.871" "0.588" "1.062" "1.231" "0.720" "1.084" "0.912" "1.857" "124.6" "121.0" "108.5" "73.3" "132.4" "153.4" "89.8" "135.1" "113.6" "231.4" "" "" "" "" "" "" "" "" "" "" "112.5" "93.4" "83.9" "49.4" "110.4" "130.9" "76.1" "97.7" "76.6" "231.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8211975543562738760" "False" "High" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "0.000" "False" "21.243" "17" "5" "7" "5" "249" "28.4" "9.23" "22.73" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "mRNA Splicing - Major Pathway; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "Eukaryotic transcription initiation" "33" "0" "0.983" "0.925" "0.870" "0.953" "0.922" "0.941" "0.906" "0.858" "0.874" "441.3" "433.8" "408.3" "383.9" "420.4" "406.8" "415.2" "399.8" "378.4" "385.5" "" "" "" "" "" "" "" "" "" "" "398.3" "334.6" "315.8" "258.5" "350.7" "347.2" "352.2" "289.3" "255.3" "385.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711793945183504944" "False" "High" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "0.000" "False" "21.239" "17" "2" "12" "2" "173" "18.9" "4.88" "31.65" "2" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905; ENSG00000291958" "GCSH" "hsa:2653; P23434; Q9H1E9" "Glycine degradation" "" "2" "0" "1.053" "1.161" "0.847" "1.025" "1.202" "0.984" "0.997" "1.121" "0.622" "159.7" "168.2" "185.3" "135.2" "163.7" "191.9" "157.1" "159.2" "179.0" "99.3" "" "" "" "" "" "" "" "" "" "" "144.1" "129.7" "143.3" "91.0" "136.6" "163.8" "133.3" "115.2" "120.7" "99.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583280322088088435" "False" "High" "IsMasterProtein" "Q9NPF4" "tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1" "0.000" "False" "21.234" "13" "5" "9" "5" "335" "36.4" "6.35" "29.58" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00814" "55644" "ENSG00000092094; ENSG00000291794" "OSGEP" "hsa:55644; Q6IAC3; Q9NPF4" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.970" "0.905" "1.014" "1.017" "0.899" "0.981" "0.948" "0.927" "0.762" "671.2" "650.9" "607.7" "680.9" "682.3" "603.5" "658.7" "636.1" "622.2" "511.7" "" "" "" "" "" "" "" "" "" "" "605.9" "502.1" "470.0" "458.5" "569.1" "515.1" "558.7" "460.3" "419.6" "511.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7598274604461767952" "False" "High" "IsMasterProtein" "P49750" "YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4" "0.000" "False" "21.168" "2" "6" "6" "6" "2146" "241.5" "6.55" "20.38" "6" "other biological processes" "nucleus" "" "Pf13671" "56252" "ENSG00000119596" "YLPM1" "hsa:56252; P49750; P49752; Q96I64; Q9P1V7" "" "" "0" "0" "1.069" "1.740" "0.981" "1.128" "1.627" "1.260" "1.112" "1.790" "1.679" "46.4" "49.6" "80.7" "45.5" "52.3" "75.5" "58.4" "51.6" "83.0" "77.9" "" "" "" "" "" "" "" "" "" "" "41.9" "38.2" "62.4" "30.6" "43.7" "64.4" "49.6" "37.3" "56.0" "77.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7680692845404357414" "False" "High" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "0.000" "False" "21.162" "27" "5" "9" "5" "196" "22.2" "5.57" "27.53" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "0.996" "0.821" "1.048" "0.889" "0.737" "0.952" "1.028" "0.780" "0.767" "882.3" "878.8" "724.5" "924.6" "784.0" "650.6" "839.7" "907.4" "687.9" "677.0" "" "" "" "" "" "" "" "" "" "" "796.4" "677.8" "560.3" "622.6" "654.0" "555.3" "712.3" "656.7" "464.0" "677.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425175822669482526" "False" "High" "IsMasterProtein" "Q9NRY5" "Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4" "0.000" "False" "21.160" "9" "4" "5" "4" "505" "55.4" "4.88" "17.32" "4" "" "" "other molecular function" "Pf05334" "10827" "ENSG00000055147" "FAM114A2" "B2R8D8; hsa:10827; Q9H7E0; Q9NRY5" "Signaling by BRAF and RAF1 fusions" "" "1" "0" "0.917" "0.910" "1.024" "0.922" "0.901" "0.995" "1.003" "0.876" "0.947" "327.8" "300.4" "298.4" "335.6" "302.2" "295.4" "326.0" "328.6" "287.1" "310.3" "" "" "" "" "" "" "" "" "" "" "295.9" "231.7" "230.8" "226.0" "252.1" "252.1" "276.5" "237.8" "193.7" "310.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8991505405555366750" "False" "High" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "0.000" "False" "21.154" "11" "6" "7" "6" "518" "58.4" "9.11" "20.15" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.034" "0.905" "1.027" "1.085" "0.857" "0.939" "0.954" "0.951" "0.435" "503.8" "520.8" "456.1" "517.6" "546.6" "431.9" "473.2" "480.5" "479.2" "219.4" "" "" "" "" "" "" "" "" "" "" "454.8" "401.7" "352.8" "348.6" "456.0" "368.6" "401.4" "347.8" "323.2" "219.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5987314834012537405" "False" "High" "IsMasterProtein" "O60888" "Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2" "0.000" "False" "21.138" "16" "2" "6" "2" "179" "19.1" "5.50" "18.14" "2" "other biological processes" "other membranes" "other molecular function" "Pf03091" "51596" "ENSG00000112514; ENSG00000226492" "CUTA" "A2AB26; A2BEL4; hsa:51596; O60888; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9" "" "" "0" "0" "1.238" "1.117" "0.830" "0.939" "1.170" "1.335" "1.191" "1.185" "0.695" "25.8" "32.0" "28.9" "21.4" "24.3" "30.2" "34.5" "30.7" "30.6" "17.9" "" "" "" "" "" "" "" "" "" "" "23.3" "24.7" "22.3" "14.4" "20.2" "25.8" "29.2" "22.2" "20.6" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5794288011295636240" "False" "High" "IsMasterProtein" "O60502" "Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2" "0.000" "False" "21.132" "7" "7" "7" "7" "916" "102.8" "4.91" "21.67" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07555" "10724" "ENSG00000198408" "OGA" "B7WPB9; D3DR79; E9PGF9; hsa:10724; O60502; O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0" "" "" "0" "0" "1.003" "0.841" "1.016" "1.044" "0.868" "1.112" "1.051" "0.891" "1.010" "668.2" "670.2" "562.2" "679.1" "697.8" "579.7" "743.3" "702.1" "595.5" "674.9" "" "" "" "" "" "" "" "" "" "" "603.1" "516.9" "434.8" "457.3" "582.1" "494.8" "630.5" "508.1" "401.7" "674.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2725190465399901470" "False" "High" "IsMasterProtein" "P62829" "Large ribosomal subunit protein uL14 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "0.000" "False" "21.101" "31" "5" "11" "5" "140" "14.9" "10.51" "33.18" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "15" "0" "0.971" "1.138" "0.991" "1.023" "1.045" "1.085" "1.092" "1.149" "0.448" "308.4" "299.5" "350.9" "305.8" "315.4" "322.2" "334.6" "336.9" "354.5" "138.3" "" "" "" "" "" "" "" "" "" "" "278.4" "231.0" "271.4" "205.9" "263.1" "275.0" "283.8" "243.8" "239.1" "138.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5713044218766232811" "False" "High" "IsMasterProtein" "Q9NXR7" "BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2" "0.000" "False" "21.082" "11" "4" "5" "4" "383" "43.5" "5.81" "17.99" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06113" "9577" "ENSG00000158019" "BABAM2" "A8K4X1; D6W562; D6W563; hsa:9577; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; Q9NXR7" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "0.905" "1.047" "1.036" "1.003" "0.901" "1.105" "0.969" "0.945" "0.724" "146.5" "132.5" "153.3" "151.8" "147.0" "132.0" "161.9" "141.9" "138.4" "106.0" "" "" "" "" "" "" "" "" "" "" "132.2" "102.2" "118.6" "102.2" "122.6" "112.6" "137.3" "102.7" "93.4" "106.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5564362200897381814" "False" "High" "IsMasterProtein" "Q9P2N5" "RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2" "0.000" "False" "21.065" "4" "4" "5" "4" "1060" "118.6" "9.19" "18.27" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00076, Pf00642, Pf01480" "54439" "ENSG00000091009" "RBM27" "hsa:54439; Q8IYW9; Q9P2N5" "" "" "0" "0" "1.141" "1.294" "1.076" "1.106" "1.414" "1.095" "1.147" "1.354" "1.863" "126.4" "144.3" "163.6" "136.0" "139.8" "178.7" "138.4" "145.0" "171.2" "235.5" "" "" "" "" "" "" "" "" "" "" "114.1" "111.3" "126.5" "91.6" "116.7" "152.5" "117.4" "104.9" "115.5" "235.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462981975688921114" "False" "High" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "0.000" "False" "21.054" "3" "2" "3" "2" "733" "81.7" "7.88" "13.98" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "0.999" "0.752" "1.010" "1.003" "0.823" "1.008" "0.814" "0.865" "0.895" "204.2" "204.0" "153.5" "206.2" "204.7" "168.0" "205.9" "166.2" "176.7" "182.8" "" "" "" "" "" "" "" "" "" "" "184.3" "157.4" "118.7" "138.8" "170.8" "143.4" "174.7" "120.3" "119.2" "182.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842107794335973179" "False" "High" "IsMasterProtein" "P15336" "Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens OX=9606 GN=ATF2 PE=1 SV=4" "0.000" "False" "21.035" "6" "3" "5" "2" "505" "54.5" "7.88" "17.71" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "1386" "ENSG00000115966" "ATF2" "A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5; hsa:1386; P15336; Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; Q96JT8" "NGF-stimulated transcription; Heme signaling; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; HATs acetylate histones; Activation of the AP-1 family of transcription factors; Response of EIF2AK4 (GCN2) to amino acid deficiency" "Energy metabolism; IL-1 signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Myometrial relaxation and contraction pathways; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; DNA IR-double strand breaks and cellular response via ATM; Ethanol effects on histone modifications; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; 10q11.21q11.23 copy number variation syndrome; T-cell receptor signaling pathway" "36" "0" "0.972" "0.774" "1.131" "0.767" "0.773" "0.860" "0.988" "0.866" "0.576" "113.4" "110.2" "87.8" "128.3" "87.0" "87.7" "97.6" "112.1" "98.3" "65.3" "" "" "" "" "" "" "" "" "" "" "102.4" "85.0" "67.9" "86.4" "72.6" "74.9" "82.8" "81.1" "66.3" "65.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6036677964263745223" "False" "High" "IsMasterProtein" "Q8NFH4" "Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1" "0.000" "False" "21.033" "16" "5" "11" "5" "326" "36.7" "5.92" "31.33" "5" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "79023" "ENSG00000075188" "NUP37" "hsa:79023; Q8NFH4; Q9H644" "Separation of Sister Chromatids; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; SUMOylation of chromatin organization proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "1.023" "0.921" "0.999" "1.058" "0.892" "1.057" "1.098" "0.940" "0.915" "391.0" "400.1" "360.1" "390.8" "413.8" "348.7" "413.3" "429.4" "367.4" "357.7" "" "" "" "" "" "" "" "" "" "" "353.0" "308.6" "278.5" "263.2" "345.2" "297.6" "350.6" "310.7" "247.8" "357.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8205136122998856932" "False" "High" "IsMasterProtein" "P60981" "Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3" "0.000" "False" "21.032" "24" "4" "7" "3" "165" "18.5" "7.85" "25.10" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00241" "11034" "ENSG00000125868" "DSTN" "B2R6N2; B4DYA6; hsa:11034; P18282; P60981; Q5W166; Q6IAW2" "" "Androgen receptor signaling pathway" "1" "0" "0.898" "0.975" "0.881" "0.904" "1.023" "0.917" "0.944" "1.023" "0.800" "720.8" "647.4" "703.0" "635.1" "651.6" "737.1" "660.9" "680.1" "737.0" "576.4" "" "" "" "" "" "" "" "" "" "" "650.6" "499.4" "543.7" "427.7" "543.5" "629.1" "560.6" "492.2" "497.1" "576.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869717489525171844" "False" "High" "IsMasterProtein" "O60306" "RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4" "0.000" "False" "21.028" "5" "7" "8" "7" "1485" "171.2" "6.37" "23.48" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf16399, Pf21143, Pf21144" "9716" "ENSG00000021776" "AQR" "A0JP17; A5YKK3; hsa:9716; O60306; Q2YDX9; Q6IRU8; Q6PIC8" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "5" "0" "0.984" "1.049" "1.159" "0.863" "1.095" "0.966" "1.039" "1.095" "1.566" "370.6" "364.8" "388.7" "429.3" "319.9" "405.9" "358.0" "384.9" "405.6" "580.2" "" "" "" "" "" "" "" "" "" "" "334.5" "281.4" "300.7" "289.1" "266.8" "346.5" "303.7" "278.6" "273.6" "580.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2819385337701029723" "False" "High" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "0.000" "False" "21.027" "7" "3" "5" "3" "627" "70.7" "8.56" "22.02" "3" "other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "0.959" "1.282" "0.827" "0.834" "0.733" "1.826" "1.087" "1.531" "1.595" "11.8" "11.3" "15.1" "9.7" "9.8" "8.6" "21.5" "12.8" "18.0" "18.8" "" "" "" "" "" "" "" "" "" "" "10.6" "8.7" "11.7" "6.6" "8.2" "7.4" "18.2" "9.3" "12.2" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4220399671961536759" "False" "High" "IsMasterProtein" "Q92918" "Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP4K1 PE=1 SV=1" "0.000" "False" "21.026" "8" "6" "6" "6" "833" "91.2" "8.34" "17.25" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11184" "ENSG00000104814" "MAP4K1" "hsa:11184; Q92918" "" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; T-cell receptor signaling pathway" "14" "0" "1.044" "1.031" "0.990" "1.073" "0.998" "1.016" "1.057" "1.016" "1.304" "320.0" "334.1" "330.0" "316.8" "343.4" "319.3" "325.1" "338.2" "325.0" "417.2" "" "" "" "" "" "" "" "" "" "" "288.9" "257.7" "255.3" "213.3" "286.5" "272.6" "275.8" "244.7" "219.2" "417.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3668121595413898342" "False" "High" "IsMasterProtein" "Q96D46" "60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1" "0.000" "False" "21.026" "12" "6" "7" "6" "503" "57.6" "7.14" "18.07" "6" "transport;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04981, Pf21192, Pf21193" "51068" "ENSG00000169251" "NMD3" "D3DNM7; hsa:51068; Q96D46; Q9Y2Z6" "" "" "0" "0" "0.994" "0.902" "0.986" "1.002" "0.967" "0.938" "0.819" "1.017" "0.844" "144.9" "144.0" "130.7" "142.9" "145.2" "140.1" "135.8" "118.7" "147.4" "122.3" "" "" "" "" "" "" "" "" "" "" "130.8" "111.1" "101.1" "96.2" "121.1" "119.6" "115.2" "85.9" "99.4" "122.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6501697818920195355" "False" "High" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "0.000" "False" "21.024" "14" "4" "6" "4" "282" "31.5" "5.52" "22.18" "4" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "0.988" "0.975" "1.037" "1.015" "0.953" "0.990" "1.035" "0.949" "0.440" "492.9" "487.3" "480.5" "511.0" "500.4" "470.0" "488.1" "510.3" "467.6" "216.7" "" "" "" "" "" "" "" "" "" "" "445.0" "375.9" "371.6" "344.1" "417.5" "401.1" "414.0" "369.3" "315.4" "216.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350737749617918576" "False" "High" "IsMasterProtein" "Q5TAQ9" "DDB1- and CUL4-associated factor 8 OS=Homo sapiens OX=9606 GN=DCAF8 PE=1 SV=1" "0.000" "False" "21.017" "8" "5" "5" "5" "597" "66.8" "5.39" "16.91" "5" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400" "50717" "ENSG00000132716" "DCAF8" "D3DVE6; hsa:50717; Q12839; Q4QQI6; Q53F14; Q5TAQ9; Q66K50; Q68CS7; Q96E00" "Neddylation" "" "1" "0" "1.014" "0.935" "1.002" "1.051" "0.969" "1.052" "1.019" "0.920" "1.144" "552.9" "560.4" "516.8" "554.1" "581.2" "535.8" "581.9" "563.2" "508.4" "632.6" "" "" "" "" "" "" "" "" "" "" "499.1" "432.2" "399.8" "373.1" "484.8" "457.3" "493.6" "407.6" "342.9" "632.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2128989799875943394" "False" "High" "IsMasterProtein" "Q92888" "Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2" "0.000" "False" "21.008" "7" "5" "6" "5" "912" "102.4" "5.66" "19.02" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00621, Pf09128, Pf17838" "9138" "ENSG00000076928" "ARHGEF1" "hsa:9138; O00513; Q6NX52; Q8N4J4; Q92888; Q96BF4; Q96F17; Q9BSB1" "RHOA GTPase cycle; RHOC GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "9" "0" "1.240" "0.798" "1.008" "0.949" "0.817" "1.211" "0.609" "1.015" "3.977" "38.0" "47.1" "30.3" "38.3" "36.1" "31.1" "46.0" "23.1" "38.6" "151.1" "" "" "" "" "" "" "" "" "" "" "34.3" "36.3" "23.5" "25.8" "30.1" "26.5" "39.0" "16.7" "26.0" "151.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2946380844768102927" "False" "High" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "0.000" "False" "21.005" "13" "8" "10" "6" "572" "61.6" "8.38" "24.42" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "1.000" "1.131" "0.981" "1.088" "1.105" "1.068" "1.020" "1.170" "2.150" "339.6" "339.5" "384.2" "333.0" "369.5" "375.2" "362.6" "346.2" "397.3" "730.0" "" "" "" "" "" "" "" "" "" "" "306.5" "261.8" "297.1" "224.3" "308.2" "320.2" "307.6" "250.5" "268.0" "730.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-997186877852076993" "False" "High" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "0.000" "False" "20.950" "18" "6" "8" "6" "352" "39.6" "5.19" "21.61" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "Striated Muscle Contraction; RND3 GTPase cycle; RHOBTB2 GTPase cycle" "VEGFA-VEGFR2 signaling" "4" "0" "1.134" "1.081" "1.027" "1.028" "1.126" "1.015" "0.924" "1.099" "2.362" "207.0" "234.8" "223.8" "212.6" "212.8" "233.0" "210.2" "191.3" "227.4" "488.9" "" "" "" "" "" "" "" "" "" "" "186.8" "181.1" "173.1" "143.1" "177.5" "198.9" "178.3" "138.4" "153.4" "488.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3545967028758689053" "False" "High" "IsMasterProtein" "P36543" "V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1" "0.000" "False" "20.950" "21" "5" "6" "5" "226" "26.1" "8.00" "19.37" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01991" "529" "ENSG00000131100" "ATP6V1E1" "A8MUE4; A8MUN4; hsa:529; P36543" "Insulin receptor recycling; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Transferrin endocytosis and recycling; Ion channel transport" "VEGFA-VEGFR2 signaling; Proximal tubule transport" "7" "0" "0.976" "1.073" "0.920" "0.957" "1.064" "1.094" "0.996" "1.015" "0.802" "339.0" "331.0" "363.6" "311.7" "324.4" "360.6" "370.7" "337.7" "343.9" "271.7" "" "" "" "" "" "" "" "" "" "" "306.0" "255.3" "281.3" "209.9" "270.6" "307.8" "314.4" "244.4" "231.9" "271.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636260914267966179" "False" "High" "IsMasterProtein" "Q6YP21" "Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1" "0.000" "False" "20.937" "14" "6" "7" "6" "454" "51.4" "8.19" "18.27" "6" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00155" "56267" "ENSG00000137944" "KYAT3" "B3KQ13; hsa:56267; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q6YP21; Q9BVY5" "Tryptophan catabolism" "Tryptophan metabolism" "2" "0" "1.204" "1.218" "1.076" "1.189" "1.135" "1.111" "1.057" "1.279" "0.822" "85.5" "103.0" "104.2" "92.0" "101.7" "97.1" "95.0" "90.5" "109.4" "70.3" "" "" "" "" "" "" "" "" "" "" "77.2" "79.5" "80.6" "62.0" "84.8" "82.9" "80.6" "65.5" "73.8" "70.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613471079569612470" "False" "High" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "0.000" "False" "20.923" "10" "6" "8" "5" "589" "64.1" "8.22" "27.21" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "mRNA processing; Hippocampal synaptogenesis and neurogenesis" "4" "0" "0.980" "1.491" "0.985" "1.131" "1.444" "1.091" "0.079" "1.498" "18.947" "146.2" "143.3" "217.9" "144.0" "165.3" "211.0" "159.6" "11.5" "218.9" "2769.9" "" "" "" "" "" "" "" "" "" "" "132.0" "110.5" "168.5" "97.0" "137.9" "180.1" "135.3" "8.3" "147.7" "2769.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874885037648560876" "False" "High" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "0.000" "False" "20.854" "28" "6" "8" "6" "148" "16.4" "9.95" "23.32" "6" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "1.150" "1.215" "1.124" "1.010" "1.169" "1.156" "1.316" "1.142" "0.760" "322.3" "370.6" "391.6" "362.2" "325.6" "376.9" "372.7" "424.1" "368.2" "245.0" "" "" "" "" "" "" "" "" "" "" "290.9" "285.9" "302.9" "243.9" "271.6" "321.7" "316.2" "306.9" "248.3" "245.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1641780535886565556" "False" "High" "IsMasterProtein" "Q7L1T6" "Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1" "0.000" "False" "20.849" "12" "6" "7" "6" "521" "59.4" "7.72" "22.49" "6" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00173, Pf00175, Pf00970, Pf04969" "51167" "ENSG00000065615" "CYB5R4" "B1AEM2; hsa:51167; Q5TGI9; Q7L1T6; Q9NUE4; Q9UHI9" "Erythrocytes take up carbon dioxide and release oxygen" "Oxidation by cytochrome P450" "2" "0" "1.180" "0.865" "1.185" "0.940" "0.846" "1.112" "1.075" "0.855" "0.929" "201.2" "237.5" "174.2" "238.6" "189.2" "170.2" "223.9" "216.2" "172.1" "186.9" "" "" "" "" "" "" "" "" "" "" "181.7" "183.2" "134.7" "160.6" "157.8" "145.3" "189.9" "156.5" "116.1" "186.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3689472973843486022" "False" "High" "IsMasterProtein" "O00505" "Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2" "0.000" "False" "20.840" "7" "4" "5" "2" "521" "57.8" "4.94" "16.09" "4" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3839" "ENSG00000102753" "KPNA3" "hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "" "2" "2" "0.918" "0.953" "1.058" "1.089" "1.004" "1.085" "0.997" "0.958" "1.195" "375.5" "344.6" "358.0" "397.2" "409.0" "376.9" "407.5" "374.5" "359.6" "448.7" "" "" "" "" "" "" "" "" "" "" "339.0" "265.8" "276.9" "267.5" "341.2" "321.7" "345.7" "271.0" "242.6" "448.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4135876604710417259" "False" "High" "IsMasterProtein" "P49593" "Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3" "0.000" "False" "20.817" "7" "2" "5" "2" "454" "49.8" "5.10" "15.59" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00481" "9647" "ENSG00000100034" "PPM1F" "A8K6G3; B7Z2C3; hsa:9647; P49593; Q96PM2" "Negative regulation of NMDA receptor-mediated neuronal transmission" "" "1" "0" "1.044" "0.966" "0.976" "0.913" "1.091" "0.903" "0.881" "1.023" "0.784" "222.3" "232.0" "214.8" "217.0" "203.0" "242.5" "200.7" "195.7" "227.4" "174.3" "" "" "" "" "" "" "" "" "" "" "200.6" "179.0" "166.1" "146.1" "169.4" "206.9" "170.3" "141.6" "153.4" "174.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9216601272429108085" "False" "High" "IsMasterProtein" "Q96GX9" "Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1" "0.000" "False" "20.806" "19" "4" "8" "4" "242" "27.1" "7.12" "21.98" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00596" "51074" "ENSG00000149089" "APIP" "A8K9D3; hsa:51074; Q6PJX6; Q8WVU2; Q96GX9; Q96HK2; Q9Y318" "Regulation of the apoptosome activity; Methionine salvage pathway" "Methionine de novo and salvage pathway" "4" "0" "1.082" "1.057" "0.999" "0.882" "1.056" "0.967" "1.105" "1.025" "0.642" "123.1" "133.3" "130.1" "123.0" "108.6" "130.1" "119.0" "136.0" "126.1" "79.1" "" "" "" "" "" "" "" "" "" "" "111.1" "102.8" "100.6" "82.9" "90.6" "111.0" "101.0" "98.4" "85.1" "79.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077624206486076316" "False" "High" "IsMasterProtein" "Q8TC07" "TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2" "0.000" "False" "20.805" "9" "5" "6" "5" "691" "79.4" "5.67" "16.23" "5" "other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00566, Pf12068" "64786" "ENSG00000121749" "TBC1D15" "B4DMT9; B9A6L6; hsa:64786; J3KNI9; Q8TC07; Q9HA83" "TBC/RABGAPs" "" "1" "0" "0.993" "0.673" "1.017" "1.063" "0.819" "0.977" "0.738" "0.853" "1.634" "87.6" "87.0" "59.0" "89.1" "93.1" "71.8" "85.6" "64.6" "74.8" "143.2" "" "" "" "" "" "" "" "" "" "" "79.1" "67.1" "45.6" "60.0" "77.7" "61.3" "72.6" "46.8" "50.4" "143.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2739049111137792080" "False" "High" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "0.000" "False" "20.790" "15" "5" "7" "5" "404" "45.5" "5.07" "22.65" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "Factors involved in megakaryocyte development and platelet production; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "Myometrial relaxation and contraction pathways; G protein signaling pathways; TGF-beta signaling pathway; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "22" "0" "0.961" "1.097" "0.934" "1.090" "1.145" "0.957" "0.965" "1.150" "1.110" "501.0" "481.4" "549.4" "467.8" "546.0" "573.9" "479.6" "483.5" "576.2" "556.3" "" "" "" "" "" "" "" "" "" "" "452.3" "371.3" "424.9" "315.0" "455.5" "489.8" "406.8" "349.9" "388.6" "556.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4921032794514216116" "False" "High" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "0.000" "False" "20.789" "18" "4" "5" "4" "260" "29.9" "5.73" "18.78" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "0.918" "1.067" "1.087" "0.934" "1.066" "0.961" "0.982" "1.075" "0.989" "298.8" "274.2" "318.9" "324.9" "279.2" "318.4" "287.3" "293.5" "321.1" "295.5" "" "" "" "" "" "" "" "" "" "" "269.7" "211.5" "246.7" "218.8" "232.9" "271.7" "243.7" "212.4" "216.6" "295.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8862135404577219062" "False" "High" "IsMasterProtein" "Q9UJZ1" "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" "0.000" "False" "20.786" "15" "4" "4" "4" "356" "38.5" "7.39" "13.72" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf01145, Pf16200" "30968" "ENSG00000165283" "STOML2" "B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1" "Processing of SMDT1; Cellular response to mitochondrial stress" "" "2" "0" "1.086" "1.219" "1.074" "1.096" "1.161" "1.068" "1.101" "1.324" "0.948" "300.8" "326.7" "366.7" "323.1" "329.7" "349.1" "321.3" "331.2" "398.1" "285.2" "" "" "" "" "" "" "" "" "" "" "271.5" "252.0" "283.6" "217.5" "275.0" "298.0" "272.6" "239.7" "268.5" "285.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6002739480164065296" "False" "High" "IsMasterProtein" "Q14137" "Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2" "0.000" "False" "20.774" "5" "3" "4" "3" "746" "83.6" "6.19" "17.84" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08145" "23246" "ENSG00000261236" "BOP1" "hsa:23246; Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.086" "3.235" "1.104" "1.086" "3.489" "1.041" "1.013" "3.478" "2.177" "45.3" "49.1" "146.4" "49.9" "49.1" "157.9" "47.1" "45.8" "157.4" "98.5" "" "" "" "" "" "" "" "" "" "" "40.8" "37.9" "113.2" "33.6" "41.0" "134.8" "40.0" "33.2" "106.1" "98.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3792046426100688845" "False" "High" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "0.000" "False" "20.773" "6" "4" "5" "4" "683" "77.5" "9.50" "17.93" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.918" "0.885" "0.947" "1.000" "0.888" "0.913" "0.811" "0.856" "3.028" "239.5" "219.8" "211.9" "226.7" "239.6" "212.7" "218.8" "194.2" "205.0" "725.4" "" "" "" "" "" "" "" "" "" "" "216.2" "169.5" "163.9" "152.7" "199.9" "181.5" "185.6" "140.6" "138.3" "725.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765443992663171126" "False" "High" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "0.000" "False" "20.742" "7" "6" "7" "3" "772" "87.6" "8.41" "22.63" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "" "miRNA regulation of DNA damage response; DNA damage response" "2" "1" "1.049" "0.969" "0.846" "1.119" "0.925" "1.001" "1.120" "0.957" "0.922" "140.7" "147.5" "136.4" "119.0" "157.4" "130.2" "140.8" "157.5" "134.6" "129.7" "" "" "" "" "" "" "" "" "" "" "127.0" "113.8" "105.5" "80.1" "131.3" "111.1" "119.5" "114.0" "90.8" "129.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962760823323839829" "False" "High" "IsMasterProtein" "O43681" "ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2" "0.000" "False" "20.735" "12" "5" "8" "5" "348" "38.8" "4.91" "24.80" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf02374" "439" "ENSG00000198356" "GET3" "A6NHP8; A8K740; hsa:439; O43681; Q53FC6; Q92849" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "0.999" "0.698" "1.024" "1.007" "0.737" "1.000" "1.004" "0.743" "0.704" "694.9" "694.3" "485.1" "711.4" "699.9" "512.4" "694.7" "697.9" "516.6" "489.2" "" "" "" "" "" "" "" "" "" "" "627.2" "535.6" "375.2" "479.0" "583.8" "437.4" "589.3" "505.1" "348.4" "489.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-493599392499449744" "False" "High" "IsMasterProtein" "P53990" "IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1" "0.000" "False" "20.704" "12" "5" "7" "5" "364" "39.7" "5.35" "21.48" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03398" "9798" "ENSG00000182149" "IST1" "A8KAH5; hsa:9798; J3QLU7; P53990; Q3SYM4; Q9BQ81; Q9BWN2" "Neutrophil degranulation; Sealing of the nuclear envelope (NE) by ESCRT-III" "" "2" "0" "0.932" "1.000" "0.938" "0.927" "0.968" "0.915" "0.905" "0.927" "0.948" "542.9" "505.7" "543.1" "509.1" "503.0" "525.7" "496.6" "491.6" "503.2" "514.8" "" "" "" "" "" "" "" "" "" "" "490.0" "390.1" "420.0" "342.9" "419.6" "448.7" "421.2" "355.7" "339.4" "514.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5339836283997496681" "False" "High" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "0.000" "False" "20.703" "5" "4" "4" "4" "1332" "150.2" "5.94" "12.50" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HATs acetylate histones" "HDAC6 interactions in the central nervous system" "2" "0" "0.940" "0.993" "1.063" "0.949" "0.968" "1.034" "0.913" "0.930" "1.265" "136.6" "128.4" "135.7" "145.2" "129.6" "132.2" "141.2" "124.7" "127.1" "172.9" "" "" "" "" "" "" "" "" "" "" "123.3" "99.0" "104.9" "97.8" "108.1" "112.9" "119.8" "90.3" "85.7" "172.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2563545888999241244" "False" "High" "IsMasterProtein" "Q9P2D3" "HEAT repeat-containing protein 5B OS=Homo sapiens OX=9606 GN=HEATR5B PE=1 SV=2" "0.000" "False" "20.681" "2" "4" "6" "4" "2071" "224.2" "7.17" "17.78" "4" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf20210" "54497" "ENSG00000008869" "HEATR5B" "B5MDU8; hsa:54497; Q7Z3B2; Q9NVL7; Q9P2D3" "" "" "0" "0" "1.220" "0.940" "1.164" "1.226" "0.898" "1.095" "1.168" "0.991" "1.471" "118.8" "145.0" "111.7" "138.3" "145.7" "106.7" "130.1" "138.8" "117.8" "174.8" "" "" "" "" "" "" "" "" "" "" "107.3" "111.8" "86.4" "93.2" "121.6" "91.0" "110.4" "100.5" "79.4" "174.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7310593134022698633" "False" "High" "IsMasterProtein" "P57081" "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2" "0.000" "False" "20.661" "12" "5" "6" "5" "412" "45.5" "7.11" "18.38" "5" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00400" "10785" "ENSG00000160193" "WDR4" "A8KA58; B2RCA3; B4DNQ7; D3DSK3; hsa:10785; P57081; Q9BVM5; Q9HCR3" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.988" "0.950" "0.941" "1.096" "0.957" "1.029" "1.076" "0.920" "0.808" "447.7" "442.3" "425.2" "421.4" "490.7" "428.4" "460.5" "481.8" "411.9" "361.9" "" "" "" "" "" "" "" "" "" "" "404.1" "341.2" "328.9" "283.8" "409.3" "365.6" "390.6" "348.7" "277.8" "361.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7583524308725557668" "False" "High" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "0.000" "False" "20.654" "11" "4" "6" "4" "351" "38.7" "6.09" "16.03" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf07676, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.033" "0.842" "0.984" "1.061" "0.897" "1.043" "0.985" "0.895" "1.078" "396.0" "409.0" "333.4" "389.9" "420.3" "355.2" "413.1" "390.1" "354.5" "426.8" "" "" "" "" "" "" "" "" "" "" "357.5" "315.4" "257.8" "262.5" "350.6" "303.2" "350.4" "282.3" "239.1" "426.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2846560637843554470" "False" "High" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "0.000" "False" "20.649" "14" "5" "7" "5" "308" "34.5" "5.12" "23.71" "5" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "0.890" "0.839" "0.909" "0.897" "0.994" "0.883" "0.906" "0.993" "0.901" "325.4" "289.8" "272.9" "295.8" "291.8" "323.6" "287.4" "294.7" "323.3" "293.2" "" "" "" "" "" "" "" "" "" "" "293.8" "223.5" "211.1" "199.2" "243.4" "276.2" "243.8" "213.3" "218.0" "293.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4947084340596136770" "False" "High" "IsMasterProtein" "Q8TF05" "Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP4R1 PE=1 SV=1" "0.000" "False" "20.629" "5" "6" "7" "6" "950" "106.9" "4.77" "21.80" "6" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "enzyme regulator activity" "Pf02985, Pf15017" "9989" "ENSG00000154845" "PPP4R1" "hsa:9989; Q8TF05; Q99774; Q9UNQ7" "" "16p11.2 proximal deletion syndrome" "1" "0" "0.902" "0.772" "1.006" "1.077" "0.824" "0.920" "0.926" "0.810" "1.089" "239.2" "215.7" "184.7" "240.7" "257.7" "197.1" "220.2" "221.4" "193.9" "260.5" "" "" "" "" "" "" "" "" "" "" "215.9" "166.4" "142.9" "162.1" "215.0" "168.2" "186.8" "160.2" "130.8" "260.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4297435359722797915" "False" "High" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "0.000" "False" "20.626" "6" "3" "4" "2" "562" "62.6" "8.21" "15.98" "3" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Synthesis of PIPs at the plasma membrane" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "4" "1" "0.954" "0.855" "1.035" "0.991" "0.932" "1.022" "0.988" "0.870" "0.813" "395.3" "377.3" "338.0" "409.0" "391.7" "368.4" "403.9" "390.5" "344.0" "321.5" "" "" "" "" "" "" "" "" "" "" "356.9" "291.0" "261.4" "275.4" "326.7" "314.4" "342.6" "282.6" "232.0" "321.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1882529908578060163" "False" "High" "IsMasterProtein" "Q9HAS0" "Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2" "0.000" "False" "20.594" "6" "2" "3" "2" "396" "44.6" "5.03" "12.62" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf15053" "64149" "ENSG00000108666" "C17orf75" "hsa:64149; Q7Z2H4; Q9HAS0" "" "" "0" "0" "1.030" "0.951" "1.100" "1.030" "1.015" "1.044" "1.072" "0.891" "0.959" "200.6" "206.6" "190.7" "220.7" "206.6" "203.5" "209.4" "215.0" "178.8" "192.5" "" "" "" "" "" "" "" "" "" "" "181.1" "159.3" "147.5" "148.6" "172.4" "173.7" "177.7" "155.6" "120.6" "192.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373690399274413822" "False" "High" "IsMasterProtein" "Q8N543" "Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1" "0.000" "False" "20.574" "12" "5" "6" "5" "542" "63.2" "5.11" "20.95" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10637, Pf13661" "55239" "ENSG00000087263" "OGFOD1" "H3BUQ2; hsa:55239; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6" "Protein hydroxylation" "" "1" "0" "1.041" "0.866" "0.969" "1.037" "0.985" "0.981" "1.039" "0.911" "1.146" "319.4" "332.4" "276.7" "309.6" "331.3" "314.5" "313.2" "331.7" "291.1" "366.1" "" "" "" "" "" "" "" "" "" "" "288.3" "256.4" "214.0" "208.5" "276.4" "268.4" "265.6" "240.0" "196.3" "366.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1450740357169926082" "False" "High" "IsMasterProtein" "P40121" "Macrophage-capping protein OS=Homo sapiens OX=9606 GN=CAPG PE=1 SV=2" "0.000" "False" "20.572" "12" "4" "5" "4" "348" "38.5" "6.19" "15.14" "4" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "822" "ENSG00000042493" "CAPG" "B8ZZS7; D6W5K8; hsa:822; P40121; Q53SA7" "" "TYROBP causal network in microglia" "1" "0" "0.886" "1.327" "1.302" "1.159" "1.251" "1.221" "0.990" "1.167" "2.748" "37.1" "32.9" "49.2" "48.3" "43.0" "46.4" "45.3" "36.7" "43.3" "101.9" "" "" "" "" "" "" "" "" "" "" "33.5" "25.3" "38.0" "32.5" "35.8" "39.6" "38.4" "26.6" "29.2" "101.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9066609543119611752" "False" "High" "IsMasterProtein" "Q12851" "Mitogen-activated protein kinase kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP4K2 PE=1 SV=2" "0.000" "False" "20.540" "3" "2" "3" "2" "820" "91.5" "6.34" "12.78" "2" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "5871" "ENSG00000168067" "MAP4K2" "hsa:5871; Q12851; Q86VU3" "" "TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "7" "0" "1.186" "0.914" "0.930" "1.041" "1.027" "1.053" "0.929" "1.024" "1.363" "118.6" "140.7" "108.5" "110.3" "123.5" "121.8" "124.9" "110.2" "121.5" "161.7" "" "" "" "" "" "" "" "" "" "" "107.1" "108.5" "83.9" "74.3" "103.1" "104.0" "106.0" "79.8" "81.9" "161.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740518017781001578" "False" "High" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "0.000" "False" "20.540" "33" "6" "10" "6" "178" "18.9" "7.49" "27.70" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "0.935" "1.015" "0.821" "0.863" "0.934" "0.983" "0.991" "1.004" "0.680" "186.3" "174.2" "189.0" "153.0" "160.8" "174.1" "183.1" "184.6" "187.0" "126.7" "" "" "" "" "" "" "" "" "" "" "168.1" "134.4" "146.2" "103.0" "134.1" "148.6" "155.3" "133.6" "126.1" "126.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561031833154832659" "False" "High" "IsMasterProtein" "O15379" "Histone deacetylase 3 OS=Homo sapiens OX=9606 GN=HDAC3 PE=1 SV=2" "0.000" "False" "20.531" "11" "5" "8" "5" "428" "48.8" "5.16" "23.47" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "8841" "ENSG00000171720" "HDAC3" "D3DQE1; hsa:8841; O15379; O43268; Q9UEI5; Q9UEV0" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "31" "0" "1.051" "1.179" "1.026" "1.084" "1.265" "1.001" "1.044" "1.223" "1.374" "362.8" "381.3" "427.7" "372.2" "393.4" "458.8" "363.1" "378.8" "443.7" "498.7" "" "" "" "" "" "" "" "" "" "" "327.5" "294.1" "330.8" "250.7" "328.2" "391.6" "308.0" "274.1" "299.3" "498.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "215729870143927910" "False" "High" "IsMasterProtein" "P52815" "Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "0.000" "False" "20.527" "18" "3" "8" "3" "198" "21.3" "8.87" "24.70" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "4" "0" "0.962" "1.048" "0.959" "0.964" "1.149" "0.959" "1.089" "1.004" "0.642" "411.5" "395.9" "431.1" "394.7" "396.8" "473.0" "394.5" "448.3" "413.2" "264.1" "" "" "" "" "" "" "" "" "" "" "371.4" "305.4" "333.4" "265.8" "331.0" "403.7" "334.6" "324.4" "278.7" "264.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545176652009721876" "False" "High" "IsMasterProtein" "Q9P013" "Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2" "0.000" "False" "20.489" "13" "3" "10" "3" "229" "26.6" "5.71" "32.59" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04889" "51503" "ENSG00000150316" "CWC15" "B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29" "mRNA Splicing - Major Pathway" "" "1" "0" "0.987" "0.957" "0.901" "0.929" "0.987" "0.926" "0.985" "0.925" "0.518" "585.2" "577.4" "560.3" "527.3" "543.6" "577.6" "542.2" "576.2" "541.2" "303.3" "" "" "" "" "" "" "" "" "" "" "528.2" "445.4" "433.3" "355.1" "453.5" "493.0" "459.9" "417.0" "365.0" "303.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292844797767435028" "False" "High" "IsMasterProtein" "Q9H074" "Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1" "0.000" "False" "20.488" "9" "5" "7" "5" "479" "53.5" "4.81" "18.73" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854, Pf07145" "10605" "ENSG00000172239" "PAIP1" "A6NKV8; hsa:10605; O60455; Q96B61; Q9BS63; Q9H074" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "Translation factors" "4" "0" "1.111" "0.938" "1.103" "1.001" "1.007" "1.035" "1.003" "0.979" "0.836" "362.2" "402.3" "339.7" "399.5" "362.4" "364.8" "374.7" "363.2" "354.4" "303.0" "" "" "" "" "" "" "" "" "" "" "327.0" "310.3" "262.7" "269.0" "302.3" "311.3" "317.9" "262.8" "239.1" "303.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7722253779426460975" "False" "High" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "0.000" "False" "20.472" "10" "7" "7" "7" "662" "73.2" "7.18" "21.61" "7" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Neutrophil degranulation" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "3" "0" "0.943" "0.984" "1.017" "0.989" "0.900" "1.003" "0.762" "0.933" "3.697" "390.7" "368.6" "384.5" "397.5" "386.3" "351.8" "392.0" "297.7" "364.6" "1444.6" "" "" "" "" "" "" "" "" "" "" "352.7" "284.3" "297.4" "267.7" "322.2" "300.3" "332.5" "215.5" "245.9" "1444.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2629792950046784631" "False" "High" "IsMasterProtein" "Q12849" "G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3" "0.000" "False" "20.450" "10" "4" "5" "4" "480" "53.1" "6.19" "16.92" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "2926" "ENSG00000132463" "GRSF1" "B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2" "Viral mRNA Translation; Mitochondrial RNA degradation" "VEGFA-VEGFR2 signaling" "3" "0" "1.237" "1.038" "1.269" "1.190" "1.071" "1.242" "0.838" "1.053" "6.477" "106.1" "131.3" "110.1" "134.6" "126.3" "113.6" "131.8" "88.9" "111.7" "687.3" "" "" "" "" "" "" "" "" "" "" "95.8" "101.3" "85.2" "90.7" "105.3" "97.0" "111.8" "64.3" "75.4" "687.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002494153914850513" "False" "High" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "0.000" "False" "20.419" "14" "3" "4" "3" "324" "37.0" "6.77" "14.64" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Orc1 removal from chromatin; Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "65" "0" "0.899" "0.737" "0.827" "1.076" "0.830" "0.964" "0.932" "0.789" "0.912" "205.8" "185.0" "151.6" "170.2" "221.4" "170.7" "198.4" "191.7" "162.5" "187.6" "" "" "" "" "" "" "" "" "" "" "185.8" "142.7" "117.3" "114.6" "184.7" "145.7" "168.3" "138.7" "109.6" "187.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527974897574347786" "False" "High" "IsMasterProtein" "Q16778" "Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3" "0.000" "False" "20.389" "35" "5" "13" "1" "126" "13.9" "10.32" "39.52" "5" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8349" "ENSG00000184678" "H2BC21" "A3KMC7; A8K110; hsa:8349; Q16778; Q4KMY1; Q5QNX0; Q9UE88" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Replacement of protamines by nucleosomes in the male pronucleus" "" "44" "3" "1.107" "1.310" "1.124" "1.013" "1.379" "1.154" "1.078" "1.525" "1.247" "888.8" "984.0" "1163.8" "999.1" "900.3" "1225.5" "1026.0" "957.9" "1355.1" "1108.5" "" "" "" "" "" "" "" "" "" "" "802.3" "759.0" "900.2" "672.8" "751.0" "1046.0" "870.4" "693.2" "914.0" "1108.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307754887580196146" "False" "High" "IsMasterProtein" "Q13287" "N-myc-interactor OS=Homo sapiens OX=9606 GN=NMI PE=1 SV=2" "0.000" "False" "20.334" "12" "4" "5" "4" "307" "35.0" "5.34" "17.54" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "9111" "ENSG00000123609" "NMI" "B5BU69; hsa:9111; Q13287; Q53TI8; Q8WTW2; Q9BVE5" "SARS-CoV-1 activates/modulates innate immune responses" "IL-2 signaling pathway" "2" "0" "1.073" "1.077" "0.950" "1.037" "1.072" "1.090" "1.071" "1.037" "0.819" "353.2" "378.9" "380.4" "335.4" "366.3" "378.6" "385.0" "378.2" "366.3" "289.4" "" "" "" "" "" "" "" "" "" "" "318.8" "292.3" "294.2" "225.9" "305.5" "323.1" "326.6" "273.7" "247.1" "289.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2473277628257978921" "False" "High" "IsMasterProtein" "Q5SRE5" "Nucleoporin NUP188 OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1" "0.000" "False" "20.315" "4" "6" "6" "6" "1749" "195.9" "6.73" "19.98" "6" "transport" "cytosol;nucleus" "other molecular function" "Pf10487, Pf21093, Pf21094" "23511" "ENSG00000095319" "NUP188" "hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; SUMOylation of chromatin organization proteins; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "0.985" "0.848" "0.970" "1.035" "0.849" "0.964" "1.018" "0.937" "1.241" "515.0" "507.3" "436.5" "499.3" "533.0" "437.2" "496.3" "524.2" "482.3" "639.0" "" "" "" "" "" "" "" "" "" "" "464.9" "391.3" "337.6" "336.2" "444.6" "373.2" "421.0" "379.4" "325.3" "639.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4100918330742864628" "False" "High" "IsMasterProtein" "Q96GK7" "Oxaloacetate tautomerase FAHD2A, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1" "0.000" "False" "20.300" "17" "5" "8" "5" "314" "34.6" "8.24" "25.09" "5" "" "" "other molecular function" "Pf01557" "51011" "ENSG00000115042; ENSG00000292086" "FAHD2A" "hsa:51011; Q96GK7; Q9Y3B0" "" "" "0" "0" "1.142" "0.800" "1.345" "0.958" "1.215" "1.131" "0.930" "0.976" "1.113" "21.6" "24.7" "17.3" "29.1" "20.8" "26.3" "24.5" "20.1" "21.1" "24.1" "" "" "" "" "" "" "" "" "" "" "19.5" "19.1" "13.4" "19.6" "17.3" "22.5" "20.8" "14.6" "14.3" "24.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4396257609671438072" "False" "High" "IsMasterProtein" "Q8IZL8" "Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2" "0.000" "False" "20.295" "4" "2" "3" "2" "1130" "119.6" "4.34" "13.38" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08166, Pf08167" "27043" "ENSG00000141456" "PELP1" "hsa:27043; O15450; Q5EGN3; Q6NTE6; Q8IZL8; Q96FT1; Q9BU60" "Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression" "" "2" "0" "0.846" "0.922" "1.219" "1.120" "1.053" "1.050" "1.025" "1.077" "0.623" "51.3" "43.4" "47.3" "62.5" "57.4" "54.0" "53.9" "52.6" "55.2" "31.9" "" "" "" "" "" "" "" "" "" "" "46.3" "33.5" "36.6" "42.1" "47.9" "46.1" "45.7" "38.0" "37.3" "31.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172904709922305924" "False" "High" "IsMasterProtein" "Q5UIP0" "Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2" "0.000" "False" "20.294" "2" "5" "5" "5" "2472" "274.3" "5.52" "17.49" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf12231" "55183" "ENSG00000080345" "RIF1" "A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4" "Nonhomologous End-Joining (NHEJ)" "ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome" "3" "0" "0.996" "2.765" "1.334" "0.990" "2.721" "0.953" "1.149" "2.790" "2.847" "67.7" "67.5" "187.3" "90.4" "67.0" "184.3" "64.5" "77.8" "189.0" "192.8" "" "" "" "" "" "" "" "" "" "" "61.1" "52.1" "144.8" "60.8" "55.9" "157.3" "54.7" "56.3" "127.5" "192.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735659524784303490" "False" "High" "IsMasterProtein" "Q8IV50" "LysM and putative peptidoglycan-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LYSMD2 PE=1 SV=1" "0.000" "False" "20.226" "17" "4" "6" "4" "215" "23.4" "5.35" "18.49" "4" "" "" "" "Pf01476" "256586" "ENSG00000140280" "LYSMD2" "hsa:256586; Q5CZ88; Q8IV50; Q8WTV3" "" "" "0" "0" "1.019" "0.947" "1.041" "1.182" "1.020" "1.236" "1.210" "1.028" "0.815" "164.3" "167.4" "155.5" "171.0" "194.2" "167.6" "203.1" "198.8" "168.9" "133.9" "" "" "" "" "" "" "" "" "" "" "148.3" "129.1" "120.3" "115.2" "162.0" "143.1" "172.3" "143.9" "113.9" "133.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337830748365545884" "False" "High" "IsMasterProtein" "Q53FT3" "Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2" "0.000" "False" "20.205" "10" "2" "3" "2" "197" "21.6" "5.45" "14.33" "2" "cell organization and biogenesis;stress response;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf05603, Pf21057" "51501" "ENSG00000149196" "HIKESHI" "hsa:51501; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "1.025" "0.938" "0.904" "1.056" "1.052" "0.995" "1.084" "1.088" "0.703" "201.4" "206.4" "188.9" "182.0" "212.7" "211.8" "200.3" "218.2" "219.1" "141.7" "" "" "" "" "" "" "" "" "" "" "181.8" "159.2" "146.1" "122.6" "177.5" "180.8" "169.9" "157.9" "147.8" "141.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8489357358395881882" "False" "High" "IsMasterProtein" "Q86SX6" "Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2" "0.000" "False" "20.196" "32" "4" "7" "4" "157" "16.6" "6.79" "22.32" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00462" "51218" "ENSG00000182512" "GLRX5" "hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54" "Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "2" "0" "1.014" "0.994" "0.917" "0.977" "0.959" "0.912" "1.263" "0.983" "0.780" "58.6" "59.4" "58.3" "53.7" "57.3" "56.2" "53.5" "74.0" "57.6" "45.7" "" "" "" "" "" "" "" "" "" "" "52.9" "45.8" "45.1" "36.2" "47.8" "48.0" "45.4" "53.6" "38.8" "45.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-577333653668623519" "False" "High" "IsMasterProtein" "Q9HAD4" "WD repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=WDR41 PE=1 SV=3" "0.000" "False" "20.163" "12" "5" "5" "5" "459" "51.7" "5.44" "16.04" "5" "other metabolic processes;other biological processes" "other cell component" "" "Pf00400" "55255" "ENSG00000164253" "WDR41" "B4DT55; hsa:55255; Q7Z792; Q8IWG3; Q8IXA9; Q8NDA7; Q9HAD4; Q9NV62" "" "" "0" "0" "1.025" "0.844" "1.011" "1.038" "0.920" "0.965" "0.957" "0.863" "0.748" "233.6" "239.4" "197.0" "236.2" "242.4" "214.9" "225.3" "223.4" "201.6" "174.8" "" "" "" "" "" "" "" "" "" "" "210.8" "184.7" "152.4" "159.0" "202.2" "183.4" "191.1" "161.7" "136.0" "174.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848560432404461068" "False" "High" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "0.000" "False" "20.134" "17" "5" "9" "5" "308" "33.8" "8.12" "27.22" "5" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "0.906" "1.158" "0.945" "1.006" "1.064" "0.998" "1.042" "1.054" "0.802" "421.4" "381.9" "488.0" "398.4" "423.9" "448.3" "420.4" "439.2" "444.0" "337.9" "" "" "" "" "" "" "" "" "" "" "380.4" "294.6" "377.4" "268.3" "353.6" "382.6" "356.6" "317.9" "299.5" "337.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4563440572163449089" "False" "High" "IsMasterProtein" "P60520" "Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1" "0.000" "False" "20.120" "28" "4" "8" "4" "117" "13.7" "8.10" "19.83" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11345" "ENSG00000034713" "GABARAPL2" "hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7" "TBC/RABGAPs; Macroautophagy" "Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "5" "0" "0.942" "0.934" "0.927" "0.935" "0.969" "0.908" "0.951" "0.969" "0.814" "464.8" "437.9" "434.0" "430.7" "434.7" "450.6" "422.0" "442.2" "450.6" "378.4" "" "" "" "" "" "" "" "" "" "" "419.6" "337.7" "335.7" "290.0" "362.6" "384.6" "357.9" "320.0" "303.9" "378.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003283534467846840" "False" "High" "IsMasterProtein" "P40937" "Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1" "0.000" "False" "20.101" "17" "7" "9" "7" "340" "38.5" "7.20" "25.51" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5985" "ENSG00000111445" "RFC5" "A8MZ62; B3KSX8; hsa:5985; P40937" "HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "28" "0" "1.030" "0.837" "1.018" "1.067" "0.783" "1.092" "1.052" "0.794" "0.709" "514.0" "529.6" "430.4" "523.2" "548.6" "402.6" "561.5" "540.7" "408.1" "364.2" "" "" "" "" "" "" "" "" "" "" "464.0" "408.5" "332.9" "352.3" "457.6" "343.6" "476.3" "391.3" "275.2" "364.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "275596885495269995" "False" "High" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "0.000" "False" "20.008" "7" "4" "8" "4" "644" "74.4" "5.53" "22.78" "4" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "Carboxyterminal post-translational modifications of tubulin" "" "1" "0" "0.940" "0.740" "0.977" "0.892" "0.769" "0.892" "0.519" "0.957" "6.975" "216.8" "203.9" "160.5" "211.8" "193.5" "166.8" "193.4" "112.4" "207.5" "1512.5" "" "" "" "" "" "" "" "" "" "" "195.7" "157.3" "124.1" "142.6" "161.4" "142.3" "164.1" "81.4" "140.0" "1512.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8814237146634600983" "False" "High" "IsMasterProtein" "Q15642" "Cdc42-interacting protein 4 OS=Homo sapiens OX=9606 GN=TRIP10 PE=1 SV=3" "0.000" "False" "19.997" "12" "5" "6" "5" "601" "68.3" "5.73" "18.01" "5" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "9322" "ENSG00000125733" "TRIP10" "B2R8A6; B7WP22; D6W645; hsa:9322; O15184; Q15642; Q53G22; Q5TZN1; Q6FI24; Q8NFL1; Q8TCY1; Q8TDX3; Q96RJ1" "RHOQ GTPase cycle; Clathrin-mediated endocytosis" "Angiopoietin-like protein 8 regulatory pathway" "3" "0" "1.026" "0.861" "0.989" "0.953" "0.862" "0.996" "1.073" "0.953" "1.087" "222.6" "228.3" "191.7" "220.1" "212.0" "191.8" "221.7" "238.8" "212.1" "241.9" "" "" "" "" "" "" "" "" "" "" "200.9" "176.1" "148.3" "148.2" "176.8" "163.7" "188.1" "172.8" "143.1" "241.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377000983824553191" "False" "High" "IsMasterProtein" "Q8N5N7" "Large ribosomal subunit protein mL50 OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "0.000" "False" "19.989" "15" "2" "5" "2" "158" "18.3" "7.88" "17.01" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.947" "0.872" "1.136" "1.051" "0.892" "1.005" "1.024" "0.892" "0.883" "128.9" "122.1" "112.4" "146.5" "135.4" "114.9" "129.5" "132.0" "115.0" "113.9" "" "" "" "" "" "" "" "" "" "" "116.3" "94.2" "87.0" "98.6" "113.0" "98.1" "109.9" "95.5" "77.5" "113.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822975009015350041" "False" "High" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "0.000" "False" "19.987" "14" "6" "7" "6" "445" "52.2" "6.04" "15.23" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440, Pf21357" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "8" "0" "0.953" "0.897" "0.927" "0.947" "0.898" "0.926" "0.687" "0.936" "4.814" "267.7" "255.1" "240.1" "248.1" "253.6" "240.3" "247.9" "183.8" "250.5" "1288.7" "" "" "" "" "" "" "" "" "" "" "241.7" "196.8" "185.7" "167.1" "211.5" "205.1" "210.3" "133.0" "168.9" "1288.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7874915043186486884" "False" "High" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "0.000" "False" "19.951" "22" "2" "3" "2" "102" "11.5" "4.16" "11.86" "2" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "" "IL-18 signaling pathway" "1" "0" "1.113" "1.157" "1.012" "1.002" "1.087" "1.042" "1.187" "1.154" "0.683" "255.9" "284.9" "296.2" "258.9" "256.5" "278.1" "266.7" "303.7" "295.3" "174.8" "" "" "" "" "" "" "" "" "" "" "231.0" "219.8" "229.1" "174.3" "214.0" "237.4" "226.2" "219.8" "199.2" "174.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4480157126328656163" "False" "High" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "0.000" "False" "19.940" "13" "5" "9" "5" "253" "29.8" "9.06" "28.40" "5" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.978" "1.112" "0.963" "0.916" "1.008" "0.959" "1.006" "1.056" "1.000" "1048.4" "1025.5" "1165.6" "1009.7" "960.4" "1057.1" "1005.4" "1054.7" "1106.9" "1048.9" "" "" "" "" "" "" "" "" "" "" "946.4" "791.0" "901.5" "679.9" "801.1" "902.2" "852.8" "763.3" "746.6" "1048.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5470294891726501754" "False" "High" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "0.000" "False" "19.935" "11" "3" "5" "3" "342" "38.9" "5.52" "15.97" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "4" "0" "0.922" "0.946" "0.877" "1.011" "0.908" "0.779" "1.123" "0.920" "0.900" "98.5" "90.7" "93.2" "86.4" "99.6" "89.5" "76.7" "110.6" "90.6" "88.6" "" "" "" "" "" "" "" "" "" "" "88.9" "70.0" "72.1" "58.2" "83.0" "76.4" "65.1" "80.0" "61.1" "88.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220884936245267041" "False" "High" "IsMasterProtein" "Q8WUA7" "TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2" "0.000" "False" "19.928" "10" "5" "6" "5" "517" "59.1" "5.97" "18.34" "5" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "25771" "ENSG00000054611" "TBC1D22A" "B0QYI2; B0QYI3; B9A6M3; hsa:25771; Q5TE47; Q6ZUH2; Q8WUA7; Q92680; Q9BVD6; Q9UGG0; Q9UGT2; Q9UGU6; Q9UH25; Q9Y4W5" "" "" "0" "0" "1.013" "1.242" "0.964" "0.894" "1.383" "1.125" "0.965" "1.190" "0.805" "104.3" "105.7" "129.6" "100.6" "93.3" "144.3" "117.4" "100.7" "124.2" "84.0" "" "" "" "" "" "" "" "" "" "" "94.2" "81.5" "100.3" "67.7" "77.8" "123.2" "99.6" "72.9" "83.7" "84.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6636555355274069790" "False" "High" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "0.000" "False" "19.926" "45" "4" "7" "4" "83" "9.3" "5.12" "24.46" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "Mitochondrial protein import" "" "1" "0" "0.955" "0.795" "1.020" "0.955" "0.810" "0.991" "1.113" "0.797" "0.673" "528.7" "504.7" "420.4" "539.4" "505.1" "428.4" "524.0" "588.4" "421.6" "355.7" "" "" "" "" "" "" "" "" "" "" "477.2" "389.3" "325.2" "363.2" "421.3" "365.6" "444.5" "425.8" "284.3" "355.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1575369473679167499" "False" "High" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "0.000" "False" "19.912" "17" "5" "8" "5" "246" "29.1" "9.72" "20.57" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "9" "0" "1.166" "1.129" "1.065" "1.097" "1.218" "1.091" "1.211" "1.239" "0.887" "388.9" "453.6" "439.1" "414.4" "426.8" "473.8" "424.2" "470.8" "481.7" "345.1" "" "" "" "" "" "" "" "" "" "" "351.1" "349.9" "339.6" "279.0" "356.0" "404.4" "359.8" "340.7" "324.9" "345.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3906185605223521012" "False" "High" "IsMasterProtein" "Q9BY32" "Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2" "0.000" "False" "19.909" "14" "2" "5" "2" "194" "21.4" "5.66" "12.27" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01725" "3704" "ENSG00000125877" "ITPA" "A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8" "Purine catabolism; Ribavirin ADME" "" "2" "0" "0.988" "1.008" "1.059" "0.983" "1.016" "1.059" "1.073" "0.852" "0.750" "138.2" "136.6" "139.3" "146.3" "135.9" "140.4" "146.4" "148.3" "117.8" "103.7" "" "" "" "" "" "" "" "" "" "" "124.8" "105.4" "107.7" "98.5" "113.4" "119.8" "124.2" "107.3" "79.5" "103.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2805084755290845876" "False" "High" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "0.000" "False" "19.883" "8" "5" "7" "5" "790" "91.8" "6.43" "17.95" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Regulation of expression of SLITs and ROBOs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Processing of Intronless Pre-mRNAs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing; 3q29 copy number variation syndrome" "29" "0" "1.020" "0.965" "1.012" "1.048" "1.015" "0.989" "0.953" "1.092" "1.145" "488.4" "498.4" "471.5" "494.4" "511.8" "495.6" "483.2" "465.7" "533.2" "559.1" "" "" "" "" "" "" "" "" "" "" "440.9" "384.4" "364.6" "332.9" "426.9" "423.0" "409.9" "337.0" "359.6" "559.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036911108115043510" "False" "High" "IsMasterProtein" "Q96F86" "Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1" "0.000" "False" "19.874" "11" "6" "6" "6" "508" "56.0" "7.11" "18.69" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03853, Pf09532, Pf12701, Pf16598" "80153" "ENSG00000179151" "EDC3" "B3KPH0; D3DW61; hsa:80153; Q96F86; Q9H797" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.277" "1.449" "1.174" "1.224" "1.338" "1.141" "1.134" "1.390" "3.219" "64.7" "82.7" "93.8" "76.0" "79.3" "86.6" "73.9" "73.4" "90.0" "208.4" "" "" "" "" "" "" "" "" "" "" "58.4" "63.8" "72.6" "51.2" "66.1" "73.9" "62.6" "53.1" "60.7" "208.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643109724268830478" "False" "High" "IsMasterProtein" "Q8WUH1" "Protein Churchill OS=Homo sapiens OX=9606 GN=CHURC1 PE=1 SV=3" "0.000" "False" "19.861" "25" "2" "5" "2" "112" "12.9" "4.84" "18.68" "2" "signal transduction;other biological processes" "" "other molecular function" "Pf06573" "91612" "ENSG00000258289" "CHURC1" "A0A0C4DGJ7; B3KQ81; G3V1X3; G3V214; hsa:91612; Q8WUH1; Q9H3K7" "" "" "0" "0" "0.996" "1.001" "1.092" "1.136" "1.026" "1.079" "0.954" "1.113" "0.821" "263.2" "262.1" "263.3" "287.3" "299.0" "270.0" "284.0" "251.0" "292.9" "216.0" "" "" "" "" "" "" "" "" "" "" "237.6" "202.2" "203.7" "193.4" "249.4" "230.5" "240.9" "181.6" "197.6" "216.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6469801124856573436" "False" "High" "IsMasterProtein" "P36404" "ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4" "0.000" "False" "19.848" "21" "3" "5" "3" "184" "20.9" "6.34" "15.47" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00025" "402" "ENSG00000213465" "ARL2" "G3V184; hsa:402; P36404; Q9BUK8" "Post-chaperonin tubulin folding pathway; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; RAS processing" "Joubert syndrome" "4" "0" "1.171" "0.943" "1.235" "1.085" "0.917" "1.211" "1.064" "0.914" "0.830" "195.0" "228.3" "183.9" "240.8" "211.6" "178.7" "236.1" "207.5" "178.2" "161.8" "" "" "" "" "" "" "" "" "" "" "176.0" "176.1" "142.3" "162.1" "176.5" "152.5" "200.3" "150.2" "120.2" "161.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548479852001098502" "False" "High" "IsMasterProtein" "P10253" "Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4" "0.000" "False" "19.833" "5" "4" "7" "4" "952" "105.3" "6.00" "17.93" "4" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00088, Pf01055, Pf13802, Pf21365" "2548" "ENSG00000171298; ENSG00000291507" "GAA" "hsa:2548; P10253; Q09GN4; Q14351; Q16302; Q8IWE7" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen storage disease type II (GAA)" "" "3" "0" "0.952" "1.170" "0.958" "0.981" "1.108" "0.996" "1.096" "1.096" "0.723" "438.7" "417.7" "513.1" "420.1" "430.5" "486.3" "436.9" "481.0" "480.6" "317.0" "" "" "" "" "" "" "" "" "" "" "396.0" "322.2" "396.8" "282.9" "359.1" "415.0" "370.6" "348.1" "324.2" "317.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3284671458686948130" "False" "High" "IsMasterProtein" "Q14498" "RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2" "0.000" "False" "19.804" "6" "3" "4" "3" "530" "59.3" "10.10" "14.44" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00076, Pf15519" "9584" "ENSG00000131051" "RBM39" "A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1; hsa:9584; Q14498; Q14499" "mRNA Splicing - Major Pathway" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "1.002" "1.172" "1.147" "1.127" "0.998" "0.939" "0.815" "1.035" "2.895" "96.4" "96.6" "112.9" "110.6" "108.6" "96.3" "90.6" "78.6" "99.8" "279.1" "" "" "" "" "" "" "" "" "" "" "87.0" "74.5" "87.4" "74.5" "90.6" "82.2" "76.8" "56.9" "67.3" "279.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2541081725476023529" "False" "High" "IsMasterProtein" "Q8NBJ7" "Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2" "0.000" "False" "19.782" "22" "5" "6" "5" "301" "33.8" "8.00" "19.44" "5" "" "ER/Golgi" "other molecular function" "Pf03781" "25870" "ENSG00000129103" "SUMF2" "B4DU41; B4DWQ0; hsa:25870; Q14DW5; Q53ZE3; Q8NBJ7; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405" "Glycosphingolipid catabolism; The activation of arylsulfatases" "" "2" "0" "0.955" "0.974" "1.143" "1.054" "1.045" "0.969" "0.915" "1.085" "1.106" "242.0" "231.0" "235.6" "276.7" "255.1" "252.8" "234.6" "221.5" "262.5" "267.6" "" "" "" "" "" "" "" "" "" "" "218.4" "178.2" "182.3" "186.3" "212.8" "215.7" "199.0" "160.3" "177.0" "267.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8312057505130700222" "False" "High" "IsMasterProtein" "P06865" "Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2" "0.000" "False" "19.760" "13" "7" "10" "6" "529" "60.7" "5.16" "23.70" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3073" "ENSG00000213614" "HEXA" "B4DKE7; E7ENH7; hsa:3073; P06865; Q53HS8; Q6AI32" "CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXA causes GM2G1" "Degradation pathway of sphingolipids, including diseases; Glycosaminoglycan degradation" "7" "1" "1.104" "1.047" "0.992" "1.122" "1.180" "0.980" "1.042" "1.209" "0.925" "365.5" "403.4" "382.8" "362.7" "410.1" "431.3" "358.1" "380.8" "442.0" "338.0" "" "" "" "" "" "" "" "" "" "" "329.9" "311.1" "296.1" "244.3" "342.1" "368.1" "303.8" "275.6" "298.2" "338.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3857525489381916364" "False" "High" "IsMasterProtein" "A8MXV4" "Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1" "0.000" "False" "19.718" "6" "2" "5" "2" "375" "42.2" "7.64" "21.69" "2" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "" "390916" "ENSG00000213965" "NUDT19" "A8MXV4; hsa:390916" "Peroxisomal lipid metabolism; Peroxisomal protein import" "" "2" "0" "1.075" "1.121" "0.908" "1.014" "1.130" "1.138" "1.000" "1.115" "0.808" "374.0" "401.9" "419.3" "339.7" "379.3" "422.7" "425.8" "373.9" "417.1" "302.2" "" "" "" "" "" "" "" "" "" "" "337.6" "310.0" "324.3" "228.8" "316.4" "360.8" "361.2" "270.6" "281.4" "302.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6162368025994279371" "False" "High" "IsMasterProtein" "Q13395" "Probable methyltransferase TARBP1 OS=Homo sapiens OX=9606 GN=TARBP1 PE=1 SV=1" "0.000" "False" "19.712" "3" "4" "4" "4" "1621" "181.6" "7.05" "15.38" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00588" "6894" "ENSG00000059588" "TARBP1" "hsa:6894; Q13395; Q9H581" "" "" "0" "0" "1.093" "0.822" "1.135" "1.082" "0.824" "1.063" "1.079" "0.846" "0.922" "642.7" "702.4" "528.1" "729.8" "695.5" "529.4" "683.2" "693.3" "543.6" "592.7" "" "" "" "" "" "" "" "" "" "" "580.2" "541.8" "408.5" "491.4" "580.1" "451.8" "579.6" "501.7" "366.7" "592.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-163153293796965969" "False" "High" "IsMasterProtein" "Q9NWB6" "Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1" "0.000" "False" "19.702" "22" "9" "10" "8" "273" "33.2" "10.35" "30.16" "9" "" "cytosol;mitochondrion;nucleus" "" "Pf15346" "55082" "ENSG00000134884" "ARGLU1" "B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6" "" "" "0" "0" "0.937" "1.084" "1.048" "0.970" "0.949" "0.956" "0.822" "0.989" "0.677" "540.7" "506.7" "586.3" "566.5" "524.4" "513.3" "517.1" "444.7" "534.9" "366.0" "" "" "" "" "" "" "" "" "" "" "488.1" "390.8" "453.5" "381.5" "437.4" "438.1" "438.6" "321.8" "360.8" "366.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "394232053154577892" "False" "High" "IsMasterProtein" "Q92530" "Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2" "0.000" "False" "19.670" "17" "5" "8" "5" "271" "29.8" "5.74" "21.04" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf08577, Pf11566" "9491" "ENSG00000125818" "PSMF1" "A0AVQ9; D3DVW3; hsa:9491; Q92530; Q9H4I1" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "" "59" "0" "1.030" "0.896" "1.006" "1.066" "1.033" "1.088" "0.946" "0.958" "0.998" "299.8" "308.7" "268.6" "301.7" "319.7" "309.7" "326.2" "283.5" "287.3" "299.2" "" "" "" "" "" "" "" "" "" "" "270.6" "238.1" "207.8" "203.1" "266.6" "264.4" "276.7" "205.2" "193.8" "299.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327497704722334246" "False" "High" "IsMasterProtein" "Q14894" "Ketimine reductase mu-crystallin OS=Homo sapiens OX=9606 GN=CRYM PE=1 SV=1" "0.000" "False" "19.621" "16" "5" "7" "5" "314" "33.8" "5.14" "22.40" "5" "other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02423" "1428" "ENSG00000103316" "CRYM" "D5MNX0; hsa:1428; Q14894; Q5HYB7" "Lysine catabolism" "" "1" "0" "0.995" "1.090" "1.004" "1.007" "1.093" "0.981" "1.025" "1.121" "0.776" "531.7" "528.9" "579.8" "533.7" "535.6" "581.4" "521.7" "545.0" "596.0" "412.6" "" "" "" "" "" "" "" "" "" "" "480.0" "408.0" "448.4" "359.4" "446.7" "496.2" "442.5" "394.4" "402.0" "412.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8200753479416328933" "False" "High" "IsMasterProtein" "Q8NF50" "Dedicator of cytokinesis protein 8 OS=Homo sapiens OX=9606 GN=DOCK8 PE=1 SV=3" "0.000" "False" "19.592" "3" "7" "7" "7" "2099" "238.4" "6.87" "19.25" "7" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "81704" "ENSG00000107099" "DOCK8" "A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09; hsa:81704; Q3MV16; Q5JPJ1; Q8NF50; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; Q9H1Q3; Q9H308; Q9H7P2" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RHOJ GTPase cycle; RAC1 GTPase cycle" "" "4" "0" "0.933" "0.809" "1.305" "1.002" "0.915" "1.045" "0.634" "0.989" "5.448" "169.4" "158.0" "137.1" "221.2" "169.8" "155.0" "177.0" "107.3" "167.5" "923.1" "" "" "" "" "" "" "" "" "" "" "152.9" "121.9" "106.0" "148.9" "141.6" "132.3" "150.1" "77.7" "113.0" "923.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7824076810458492012" "False" "High" "IsMasterProtein" "P05165" "Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCA PE=1 SV=4" "0.000" "False" "19.567" "8" "6" "6" "6" "728" "80.0" "7.52" "14.80" "6" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786, Pf18140" "5095" "ENSG00000175198" "PCCA" "B4DKY8; B4DPF9; C9JPQ8; hsa:5095; P05165; Q15979; Q8WXQ7" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "Primary ovarian insufficiency" "4" "0" "1.017" "1.049" "1.014" "1.095" "1.088" "0.984" "1.020" "1.077" "0.737" "457.5" "465.2" "479.9" "463.8" "501.1" "498.0" "450.2" "466.6" "492.6" "337.3" "" "" "" "" "" "" "" "" "" "" "413.0" "358.9" "371.2" "312.3" "418.0" "425.0" "381.9" "337.7" "332.2" "337.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4598318327767700223" "False" "High" "IsMasterProtein" "Q96SI9" "Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1" "0.000" "False" "19.554" "6" "4" "4" "2" "672" "73.6" "8.72" "14.46" "4" "other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf00035, Pf07528, Pf20965" "55342" "ENSG00000165209" "STRBP" "hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4" "" "" "0" "0" "0.977" "1.224" "1.162" "1.135" "1.154" "1.129" "1.132" "1.350" "1.808" "135.9" "132.8" "166.3" "157.8" "154.2" "156.7" "153.4" "153.8" "183.4" "245.7" "" "" "" "" "" "" "" "" "" "" "122.6" "102.4" "128.6" "106.3" "128.6" "133.8" "130.1" "111.3" "123.7" "245.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-929965012723082693" "False" "High" "IsMasterProtein" "Q969E4" "Transcription elongation factor A protein-like 3 OS=Homo sapiens OX=9606 GN=TCEAL3 PE=1 SV=1" "0.000" "False" "19.548" "24" "4" "6" "4" "200" "22.5" "4.92" "20.17" "4" "" "nucleus" "" "Pf04538" "85012" "ENSG00000196507" "TCEAL3" "D3DXA4; hsa:85012; Q969E4" "" "" "0" "0" "1.024" "1.036" "0.909" "0.942" "0.982" "1.049" "1.152" "0.992" "0.719" "473.5" "484.8" "490.5" "430.2" "446.2" "464.9" "496.6" "545.5" "469.8" "340.3" "" "" "" "" "" "" "" "" "" "" "427.4" "373.9" "379.4" "289.7" "372.2" "396.8" "421.3" "394.7" "316.9" "340.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960640284500961057" "False" "High" "IsMasterProtein" "Q13426" "DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2" "0.000" "False" "19.521" "18" "5" "7" "5" "336" "38.3" "4.98" "17.78" "5" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06632" "7518" "ENSG00000152422" "XRCC4" "A8K3X4; hsa:7518; Q13426; Q9BS72; Q9UP94" "SUMOylation of DNA damage response and repair proteins; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "7" "0" "1.001" "0.928" "1.070" "1.116" "1.058" "0.960" "0.925" "0.925" "0.742" "144.3" "144.5" "133.9" "154.4" "161.0" "152.6" "138.5" "133.5" "133.4" "107.1" "" "" "" "" "" "" "" "" "" "" "130.3" "111.4" "103.6" "104.0" "134.3" "130.3" "117.5" "96.6" "90.0" "107.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9025151423134884799" "False" "High" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "0.000" "False" "19.517" "10" "3" "5" "3" "306" "33.9" "8.59" "17.86" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "1.012" "0.835" "1.030" "0.976" "0.876" "1.123" "0.979" "0.937" "2.209" "184.9" "187.2" "154.3" "190.5" "180.4" "162.0" "207.6" "181.0" "173.3" "408.5" "" "" "" "" "" "" "" "" "" "" "166.9" "144.4" "119.4" "128.3" "150.5" "138.2" "176.1" "131.0" "116.9" "408.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6418921267369266529" "False" "High" "IsMasterProtein" "P31321" "cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4" "0.000" "False" "19.516" "14" "5" "7" "3" "381" "43.0" "5.71" "20.33" "5" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5575" "ENSG00000188191" "PRKAR1B" "hsa:5575; P31321; Q8N422" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "21" "0" "1.008" "0.844" "0.983" "0.921" "0.828" "0.892" "0.881" "0.892" "0.856" "96.5" "97.2" "81.4" "94.8" "88.8" "79.9" "86.0" "85.0" "86.1" "82.6" "" "" "" "" "" "" "" "" "" "" "87.1" "75.0" "62.9" "63.9" "74.1" "68.2" "73.0" "61.5" "58.0" "82.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165115417245555276" "False" "High" "IsMasterProtein" "Q15293" "Reticulocalbin-1 OS=Homo sapiens OX=9606 GN=RCN1 PE=1 SV=1" "0.000" "False" "19.505" "15" "5" "7" "5" "331" "38.9" "5.00" "21.92" "5" "developmental processes" "ER/Golgi" "other molecular function" "Pf13202" "5954" "ENSG00000049449" "RCN1" "B7Z1M1; D3DR00; hsa:5954; Q15293" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "VEGFA-VEGFR2 signaling" "3" "0" "0.976" "0.946" "0.915" "0.921" "0.899" "0.901" "1.016" "0.937" "0.847" "469.8" "458.6" "444.4" "429.8" "432.8" "422.4" "423.1" "477.1" "440.0" "397.7" "" "" "" "" "" "" "" "" "" "" "424.1" "353.8" "343.7" "289.5" "361.0" "360.5" "358.9" "345.3" "296.8" "397.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755202633810832906" "False" "High" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "0.000" "False" "19.496" "8" "5" "6" "5" "747" "86.1" "6.62" "15.94" "5" "" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "Synthesis of PIPs at the early endosome membrane" "" "1" "0" "0.988" "1.068" "0.827" "1.105" "1.417" "0.918" "1.153" "1.140" "0.712" "225.3" "222.7" "240.6" "186.4" "249.0" "319.4" "206.9" "259.9" "256.9" "160.4" "" "" "" "" "" "" "" "" "" "" "203.4" "171.8" "186.1" "125.6" "207.7" "272.6" "175.5" "188.1" "173.3" "160.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858307060055438950" "False" "High" "IsMasterProtein" "Q9HAB8" "Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2" "0.000" "False" "19.475" "12" "4" "5" "4" "311" "34.0" "6.71" "10.03" "4" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04127" "79717" "ENSG00000127125" "PPCS" "hsa:79717; Q3KQT2; Q5VVM0; Q9HAB8" "Coenzyme A biosynthesis" "" "1" "0" "1.094" "1.012" "0.999" "0.980" "1.044" "1.138" "0.968" "0.952" "0.731" "152.8" "167.1" "154.6" "152.6" "149.8" "159.5" "173.8" "147.9" "145.5" "111.7" "" "" "" "" "" "" "" "" "" "" "137.9" "128.9" "119.6" "102.7" "124.9" "136.1" "147.5" "107.0" "98.1" "111.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1831448905794715132" "False" "High" "IsMasterProtein" "P84098" "Large ribosomal subunit protein eL19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1" "0.000" "False" "19.468" "17" "3" "6" "3" "196" "23.5" "11.47" "17.45" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01280" "6143" "ENSG00000108298" "RPL19" "B2R4K2; P14118; P22908; P84098; Q502Y6; Q7Z6E4" "SRP-dependent cotranslational protein targeting to membrane; Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.882" "0.990" "0.991" "1.026" "1.000" "1.015" "1.207" "0.958" "0.371" "126.7" "111.7" "125.4" "125.5" "130.0" "126.8" "128.5" "153.0" "121.4" "47.0" "" "" "" "" "" "" "" "" "" "" "114.4" "86.2" "97.0" "84.5" "108.4" "108.2" "109.0" "110.7" "81.9" "47.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248535501308075701" "False" "High" "IsMasterProtein" "P62879" "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Homo sapiens OX=9606 GN=GNB2 PE=1 SV=3" "0.000" "False" "19.429" "11" "4" "5" "2" "340" "37.3" "6.00" "13.85" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "2783" "ENSG00000172354" "GNB2" "B3KPU1; hsa:2783; P11016; P54312; P62879" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "36" "1" "1.003" "0.940" "1.107" "0.966" "0.840" "0.897" "0.908" "0.930" "0.859" "203.9" "204.5" "191.8" "225.7" "197.1" "171.3" "183.0" "185.2" "189.6" "175.2" "" "" "" "" "" "" "" "" "" "" "184.1" "157.7" "148.3" "152.0" "164.4" "146.2" "155.2" "134.0" "127.9" "175.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142144855289123481" "False" "High" "IsMasterProtein" "Q96HC4" "PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5 PE=1 SV=5" "0.000" "False" "19.423" "12" "5" "5" "5" "596" "63.9" "8.21" "14.00" "5" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "10611" "ENSG00000163110" "PDLIM5" "A8K6F9; D6RB78; E9PBF5; hsa:10611; O60705; Q56VN4; Q5UW38; Q8WVK0; Q96HC4" "Neurexins and neuroligins" "Extracellular vesicles in the crosstalk of cardiac cells" "2" "0" "1.028" "1.067" "1.232" "0.988" "0.988" "1.034" "1.100" "1.025" "0.787" "161.0" "165.5" "171.8" "198.2" "159.0" "159.1" "166.5" "177.1" "165.0" "126.7" "" "" "" "" "" "" "" "" "" "" "145.3" "127.7" "132.9" "133.5" "132.7" "135.8" "141.2" "128.2" "111.3" "126.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519635040323081051" "False" "High" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "0.000" "False" "19.404" "10" "2" "7" "1" "191" "21.2" "6.55" "22.84" "2" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "RHO GTPases Activate Formins; MAPK6/MAPK4 signaling; Factors involved in megakaryocyte development and platelet production; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; RHOU GTPase cycle; EPHB-mediated forward signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; VEGFA-VEGFR2 Pathway; Myogenesis; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "63" "0" "0.987" "0.959" "1.096" "1.075" "0.994" "1.077" "1.012" "1.130" "0.810" "689.4" "680.6" "660.8" "755.8" "741.0" "685.3" "742.6" "697.8" "779.1" "558.6" "" "" "" "" "" "" "" "" "" "" "622.3" "525.0" "511.1" "509.0" "618.1" "584.9" "629.9" "505.0" "525.5" "558.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8831328934271129534" "False" "High" "IsMasterProtein" "Q92733" "Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1" "0.000" "False" "19.400" "10" "5" "6" "5" "491" "52.4" "5.10" "21.32" "5" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf10253" "5546" "ENSG00000143294" "PRCC" "A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733" "mRNA Splicing - Major Pathway" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; IL-18 signaling pathway" "4" "0" "0.933" "0.840" "0.914" "0.902" "0.824" "0.917" "0.928" "0.799" "0.848" "686.1" "639.9" "576.5" "627.2" "618.9" "565.5" "628.9" "636.8" "547.9" "582.0" "" "" "" "" "" "" "" "" "" "" "619.3" "493.6" "445.9" "422.4" "516.3" "482.6" "533.5" "460.8" "369.6" "582.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6971851119340033318" "False" "High" "IsMasterProtein" "Q712K3" "Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1" "0.000" "False" "19.389" "13" "3" "6" "3" "238" "27.1" "4.42" "21.32" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "54926" "ENSG00000107341" "UBE2R2" "D3DRL5; hsa:54926; Q712K3; Q9NX64" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "" "2" "0" "1.016" "0.788" "1.029" "1.001" "0.884" "0.992" "0.952" "0.878" "0.852" "448.2" "455.3" "353.3" "461.1" "448.6" "396.4" "444.7" "426.7" "393.5" "382.1" "" "" "" "" "" "" "" "" "" "" "404.6" "351.2" "273.2" "310.5" "374.2" "338.3" "377.2" "308.8" "265.4" "382.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4556564044268480545" "False" "High" "IsMasterProtein" "Q9NR19" "Acetyl-coenzyme A synthetase, cytoplasmic OS=Homo sapiens OX=9606 GN=ACSS2 PE=1 SV=1" "0.000" "False" "19.329" "7" "6" "7" "6" "701" "78.5" "6.46" "19.34" "6" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00501, Pf13193, Pf16177" "55902" "ENSG00000131069" "ACSS2" "A6NE90; hsa:55902; Q5QPH2; Q5QPH3; Q8N238; Q96EL0; Q9NQP7; Q9NR19; Q9UJ15" "Transcriptional activation of mitochondrial biogenesis; Ethanol oxidation" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Lipid metabolism pathway; Ethanol effects on histone modifications; Fluoroacetic acid toxicity; Amino acid conjugation of benzoic acid" "8" "0" "1.017" "0.780" "1.064" "0.986" "0.836" "0.972" "0.944" "0.839" "0.848" "418.6" "425.7" "326.6" "445.3" "412.9" "350.1" "406.9" "395.0" "351.3" "355.1" "" "" "" "" "" "" "" "" "" "" "377.8" "328.3" "252.6" "299.9" "344.4" "298.8" "345.2" "285.9" "237.0" "355.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4778122268276291111" "False" "High" "IsMasterProtein" "P49406" "Large ribosomal subunit protein bL19m OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" "0.000" "False" "19.326" "15" "5" "5" "5" "292" "33.5" "9.50" "17.02" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01245" "9801" "ENSG00000115364" "MRPL19" "hsa:9801; P49406; Q53TX9; Q96Q52" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Cytoplasmic ribosomal proteins" "4" "0" "0.984" "0.795" "0.775" "0.955" "0.843" "0.857" "0.863" "0.802" "1.053" "198.5" "195.3" "157.8" "153.9" "189.6" "167.3" "170.1" "171.4" "159.3" "209.1" "" "" "" "" "" "" "" "" "" "" "179.2" "150.7" "122.0" "103.6" "158.1" "142.8" "144.3" "124.0" "107.4" "209.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139942290346830630" "False" "High" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "0.000" "False" "19.323" "21" "5" "6" "5" "290" "31.4" "8.07" "17.60" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "10" "0" "1.072" "1.082" "0.997" "1.145" "1.169" "1.123" "1.138" "1.148" "0.805" "199.6" "214.0" "216.0" "198.9" "228.5" "233.2" "224.1" "227.1" "229.0" "160.6" "" "" "" "" "" "" "" "" "" "" "180.1" "165.1" "167.1" "134.0" "190.6" "199.0" "190.1" "164.4" "154.5" "160.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8994364974169992098" "False" "High" "IsMasterProtein" "Q6PIJ6" "F-box only protein 38 OS=Homo sapiens OX=9606 GN=FBXO38 PE=1 SV=3" "0.000" "False" "19.316" "6" "5" "5" "5" "1188" "133.9" "6.33" "11.17" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00646" "81545" "ENSG00000145868" "FBXO38" "hsa:81545; Q6PIJ6; Q6PK72; Q7Z2U0; Q86VN3; Q9BXY6; Q9H837; Q9HC40" "" "" "0" "0" "0.877" "1.032" "1.118" "0.920" "1.092" "1.001" "1.029" "1.154" "0.749" "24.8" "21.8" "25.6" "27.7" "22.8" "27.1" "24.8" "25.5" "28.6" "18.6" "" "" "" "" "" "" "" "" "" "" "22.4" "16.8" "19.8" "18.7" "19.0" "23.1" "21.1" "18.5" "19.3" "18.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6201262043542307507" "False" "High" "IsMasterProtein" "P34896" "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" "0.000" "False" "19.312" "12" "5" "6" "4" "483" "53.0" "7.71" "20.31" "5" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6470" "ENSG00000176974; ENSG00000284320" "SHMT1" "B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2" "Metabolism of folate and pterines; Carnitine synthesis" "Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Spina bifida; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "13" "0" "1.042" "1.046" "1.021" "1.081" "1.095" "0.983" "1.094" "1.104" "0.796" "476.9" "496.8" "498.8" "486.9" "515.6" "522.4" "468.8" "521.9" "526.4" "379.7" "" "" "" "" "" "" "" "" "" "" "430.4" "383.2" "385.8" "327.9" "430.1" "445.9" "397.7" "377.7" "355.0" "379.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670278986062403757" "False" "High" "IsMasterProtein" "P17050" "Alpha-N-acetylgalactosaminidase OS=Homo sapiens OX=9606 GN=NAGA PE=1 SV=2" "0.000" "False" "19.306" "8" "3" "4" "3" "411" "46.5" "5.19" "13.69" "3" "other metabolic processes" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf16499, Pf17450" "4668" "ENSG00000198951" "NAGA" "hsa:4668; P17050" "" "" "0" "0" "0.988" "1.066" "0.954" "1.009" "1.093" "1.070" "0.929" "0.941" "0.675" "204.5" "201.9" "217.9" "195.1" "206.4" "223.5" "218.8" "190.0" "192.4" "138.1" "" "" "" "" "" "" "" "" "" "" "184.6" "155.8" "168.5" "131.4" "172.2" "190.8" "185.6" "137.5" "129.8" "138.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857218708684993243" "False" "High" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "0.000" "False" "19.281" "14" "3" "4" "3" "318" "35.2" "8.94" "16.24" "3" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Neutrophil degranulation; Pentose phosphate pathway" "Pentose phosphate pathway in senescent cells" "3" "0" "1.003" "0.913" "1.033" "1.012" "1.060" "0.999" "0.999" "1.126" "0.781" "72.7" "72.9" "66.4" "75.1" "73.6" "77.1" "72.6" "72.6" "81.9" "56.8" "" "" "" "" "" "" "" "" "" "" "65.6" "56.2" "51.3" "50.6" "61.4" "65.8" "61.6" "52.6" "55.2" "56.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6974141516308557016" "False" "High" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "0.000" "False" "19.258" "12" "3" "4" "3" "261" "28.1" "5.91" "12.55" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; O95638; Q969T9" "" "" "0" "0" "0.889" "0.962" "1.124" "1.037" "0.917" "1.058" "1.010" "0.922" "0.722" "210.9" "187.6" "203.0" "237.2" "218.8" "193.4" "223.2" "213.0" "194.5" "152.3" "" "" "" "" "" "" "" "" "" "" "190.4" "144.7" "157.0" "159.7" "182.5" "165.1" "189.3" "154.2" "131.2" "152.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957906910240928632" "False" "High" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "0.000" "False" "19.244" "7" "5" "7" "5" "750" "83.1" "6.93" "18.11" "5" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "Vitamin B12 metabolism; Amino acid metabolism" "6" "0" "0.953" "0.822" "1.028" "1.043" "0.846" "1.105" "1.077" "0.847" "1.069" "287.1" "273.7" "236.0" "295.1" "299.3" "243.0" "317.4" "309.3" "243.3" "306.8" "" "" "" "" "" "" "" "" "" "" "259.2" "211.1" "182.5" "198.7" "249.7" "207.4" "269.2" "223.9" "164.1" "306.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2463119363191037669" "False" "High" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "0.000" "False" "19.234" "11" "5" "6" "2" "453" "52.0" "6.39" "18.46" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "MASTL Facilitates Mitotic Progression" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "3" "0" "1.057" "0.999" "0.936" "1.077" "0.932" "0.930" "1.173" "0.992" "0.929" "208.4" "220.2" "208.1" "195.0" "224.4" "194.1" "193.8" "244.4" "206.7" "193.6" "" "" "" "" "" "" "" "" "" "" "188.1" "169.9" "161.0" "131.3" "187.2" "165.7" "164.4" "176.9" "139.4" "193.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7247108035044904633" "False" "High" "IsMasterProtein" "P62244" "Small ribosomal subunit protein uS8 OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "0.000" "False" "19.226" "31" "5" "13" "5" "130" "14.8" "10.13" "35.53" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.978" "1.027" "1.192" "1.084" "0.984" "1.065" "1.036" "1.020" "0.593" "687.1" "671.8" "705.5" "819.3" "745.0" "676.1" "732.1" "712.0" "701.2" "407.8" "" "" "" "" "" "" "" "" "" "" "620.3" "518.2" "545.7" "551.7" "621.5" "577.1" "621.0" "515.3" "472.9" "407.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9168897576622990740" "False" "High" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "0.000" "False" "19.202" "24" "5" "7" "5" "180" "20.3" "4.96" "20.41" "5" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "" "2" "0" "0.944" "0.960" "1.057" "0.926" "0.937" "0.970" "0.971" "0.970" "0.794" "379.0" "357.8" "363.7" "400.6" "350.8" "355.3" "367.5" "368.0" "367.5" "301.0" "" "" "" "" "" "" "" "" "" "" "342.1" "276.0" "281.3" "269.7" "292.6" "303.2" "311.7" "266.3" "247.9" "301.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112180940687261840" "False" "High" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "0.000" "False" "19.181" "19" "4" "11" "4" "160" "18.7" "4.54" "32.57" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Estrogen-dependent gene expression; Potential therapeutics for SARS; Aryl hydrocarbon receptor signalling; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Omega-6-fatty acids in senescence" "12" "0" "1.008" "0.791" "0.991" "0.931" "0.776" "1.024" "0.883" "0.805" "2.908" "828.5" "834.9" "655.4" "821.5" "771.0" "642.7" "848.8" "731.6" "667.4" "2409.2" "" "" "" "" "" "" "" "" "" "" "747.9" "644.0" "506.9" "553.2" "643.2" "548.6" "720.0" "529.5" "450.1" "2409.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097285546309815512" "False" "High" "IsMasterProtein" "Q8NEB9" "Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1" "0.000" "False" "19.180" "6" "5" "6" "5" "887" "101.5" "6.81" "16.32" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792" "5289" "ENSG00000078142" "PIK3C3" "hsa:5289; Q15134; Q8NEB9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "AMP-activated protein kinase signaling; Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Microglia pathogen phagocytosis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "24" "0" "0.904" "1.064" "0.947" "1.097" "0.950" "0.946" "0.924" "0.909" "1.112" "189.3" "171.2" "201.4" "179.3" "207.6" "179.8" "179.0" "174.9" "172.2" "210.5" "" "" "" "" "" "" "" "" "" "" "170.9" "132.1" "155.8" "120.8" "173.2" "153.4" "151.8" "126.6" "116.1" "210.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933649257231024003" "False" "High" "IsMasterProtein" "P16930" "Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2" "0.000" "False" "19.176" "9" "4" "6" "4" "419" "46.3" "6.95" "17.31" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01557, Pf09298" "2184" "ENSG00000103876" "FAH" "B2R9X1; D3DW95; hsa:2184; P16930; Q53XA7" "Tyrosine catabolism" "Amino acid metabolism" "2" "0" "0.975" "1.130" "1.043" "1.098" "1.028" "1.053" "1.129" "1.093" "0.694" "225.6" "219.8" "254.9" "235.3" "247.7" "232.0" "237.4" "254.7" "246.5" "156.6" "" "" "" "" "" "" "" "" "" "" "203.6" "169.6" "197.1" "158.5" "206.6" "198.0" "201.4" "184.3" "166.3" "156.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "315483607845859686" "False" "High" "IsMasterProtein" "Q9BRF8" "Serine/threonine-protein phosphatase CPPED1 OS=Homo sapiens OX=9606 GN=CPPED1 PE=1 SV=3" "0.000" "False" "19.174" "16" "5" "5" "5" "314" "35.5" "6.20" "16.13" "5" "" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf00149" "55313" "ENSG00000103381" "CPPED1" "B4DQ68; hsa:55313; Q6MZY9; Q9BRF8; Q9H9M9; Q9NUT6" "Neutrophil degranulation" "" "1" "0" "0.884" "1.031" "0.919" "0.940" "1.033" "0.984" "0.907" "1.002" "0.678" "360.1" "318.2" "371.2" "331.0" "338.4" "372.0" "354.4" "326.6" "361.0" "244.0" "" "" "" "" "" "" "" "" "" "" "325.0" "245.4" "287.1" "222.9" "282.3" "317.5" "300.6" "236.4" "243.5" "244.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6816418598839755867" "False" "High" "IsMasterProtein" "Q9NXC5" "GATOR2 complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "0.000" "False" "19.170" "8" "7" "7" "7" "875" "98.5" "6.73" "19.73" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17034, Pf21719, Pf21720" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "Amino acids regulate mTORC1" "" "1" "0" "1.035" "0.937" "1.022" "1.027" "0.797" "1.046" "1.037" "0.978" "0.902" "336.5" "348.3" "315.4" "343.8" "345.4" "268.2" "352.0" "349.0" "329.0" "303.3" "" "" "" "" "" "" "" "" "" "" "303.7" "268.6" "243.9" "231.5" "288.1" "228.9" "298.6" "252.6" "221.9" "303.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6698557715673705148" "False" "High" "IsMasterProtein" "Q6P3W7" "SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1" "0.000" "False" "19.165" "4" "3" "4" "3" "929" "103.6" "8.22" "13.69" "3" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "55681" "ENSG00000136021" "SCYL2" "A8KAB5; hsa:55681; Q6P3W7; Q96EF4; Q96ST4; Q9H7V5; Q9NVH3; Q9P2I7" "" "" "0" "0" "0.848" "0.907" "0.871" "1.066" "1.034" "0.909" "1.001" "0.925" "0.480" "36.2" "30.7" "32.9" "31.6" "38.6" "37.5" "32.9" "36.3" "33.5" "17.4" "" "" "" "" "" "" "" "" "" "" "32.7" "23.7" "25.4" "21.2" "32.2" "32.0" "27.9" "26.3" "22.6" "17.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639457363078970209" "False" "High" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "0.000" "False" "19.117" "9" "3" "6" "3" "375" "42.6" "8.56" "19.92" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome" "5" "0" "1.145" "1.296" "0.990" "1.092" "1.334" "0.989" "0.928" "1.517" "2.313" "121.9" "139.6" "158.0" "120.7" "133.1" "162.5" "120.5" "113.1" "184.9" "281.9" "" "" "" "" "" "" "" "" "" "" "110.0" "107.7" "122.2" "81.3" "111.0" "138.7" "102.3" "81.8" "124.7" "281.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622169396848351928" "False" "High" "IsMasterProtein" "Q8NFF5" "FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1" "0.000" "False" "19.069" "8" "5" "6" "5" "587" "65.2" "6.93" "18.41" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00994, Pf01507" "80308" "ENSG00000160688" "FLAD1" "hsa:80308; Q8N5J1; Q8N686; Q8NFF5; Q8WU93; Q8WUJ4; Q96CR8; Q99764; Q9HBN6" "Vitamin B2 (riboflavin) metabolism" "Selenium micronutrient network; Folate metabolism" "3" "0" "1.062" "0.793" "0.889" "1.125" "0.922" "0.965" "0.951" "0.782" "1.178" "164.0" "174.1" "130.0" "145.8" "184.6" "151.2" "158.3" "156.0" "128.3" "193.3" "" "" "" "" "" "" "" "" "" "" "148.0" "134.3" "100.6" "98.2" "154.0" "129.1" "134.3" "112.9" "86.5" "193.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8372926252788997109" "False" "High" "IsMasterProtein" "Q5JTZ9" "Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1" "0.000" "False" "19.066" "6" "5" "5" "5" "985" "107.3" "6.27" "15.65" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01411, Pf07973" "57505" "ENSG00000124608" "AARS2" "A2RRN5; hsa:57505; Q5JTZ9; Q8N198; Q96D02; Q9ULF0" "Mitochondrial tRNA aminoacylation" "Primary ovarian insufficiency" "2" "0" "1.083" "1.049" "1.133" "1.256" "1.091" "1.180" "0.881" "1.171" "3.023" "151.2" "163.8" "158.5" "171.4" "190.0" "165.0" "178.4" "133.2" "177.0" "457.1" "" "" "" "" "" "" "" "" "" "" "136.5" "126.4" "122.6" "115.4" "158.5" "140.8" "151.3" "96.4" "119.4" "457.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6199563702112544119" "False" "High" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "0.000" "False" "19.052" "7" "6" "6" "6" "938" "102.9" "7.02" "16.08" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "1.161" "1.001" "1.029" "0.984" "1.061" "1.009" "0.386" "1.064" "9.369" "62.1" "72.0" "62.1" "63.8" "61.1" "65.9" "62.7" "24.0" "66.0" "581.5" "" "" "" "" "" "" "" "" "" "" "56.0" "55.6" "48.0" "43.0" "50.9" "56.2" "53.1" "17.3" "44.5" "581.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830448209821531490" "False" "High" "IsMasterProtein" "Q9GZS3" "Superkiller complex protein 8 OS=Homo sapiens OX=9606 GN=SKIC8 PE=1 SV=1" "0.000" "False" "19.050" "9" "2" "4" "2" "305" "33.6" "5.47" "10.60" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "RNA Polymerase II Pre-transcription Events; mRNA decay by 3' to 5' exoribonuclease; E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex" "" "5" "0" "1.011" "0.858" "1.057" "0.918" "1.042" "1.093" "0.967" "0.999" "1.280" "212.3" "214.7" "182.1" "224.4" "194.9" "221.2" "232.1" "205.2" "212.0" "271.7" "" "" "" "" "" "" "" "" "" "" "191.6" "165.6" "140.8" "151.1" "162.6" "188.8" "196.8" "148.5" "143.0" "271.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073332157955076013" "False" "High" "IsMasterProtein" "P50914" "Large ribosomal subunit protein eL14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4" "0.000" "False" "19.043" "11" "2" "11" "2" "215" "23.4" "10.93" "34.48" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01929" "9045" "ENSG00000188846" "RPL14" "hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.802" "1.009" "0.941" "0.879" "0.905" "0.933" "1.002" "0.962" "0.586" "669.2" "537.0" "675.4" "629.7" "588.2" "605.6" "624.2" "670.3" "644.0" "392.0" "" "" "" "" "" "" "" "" "" "" "604.1" "414.2" "522.4" "424.0" "490.7" "516.9" "529.5" "485.1" "434.3" "392.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749149961980637251" "False" "High" "IsMasterProtein" "P27361" "Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4" "0.000" "False" "19.034" "15" "6" "7" "3" "379" "43.1" "6.74" "20.07" "6" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "5595" "ENSG00000102882" "MAPK3" "A8CZ58; B0LPG3; hsa:5595; P27361; Q8NHX1" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; FCGR3A-mediated phagocytosis; NCAM signaling for neurite out-growth; ISG15 antiviral mechanism; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; Signal transduction by L1; Suppression of apoptosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; RNA Polymerase I Promoter Opening; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Polycystic kidney disease pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; 2q11.2 copy number variation syndrome; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "178" "0" "1.123" "0.797" "0.973" "1.202" "0.911" "1.104" "1.073" "0.943" "0.995" "148.1" "166.2" "118.0" "144.0" "178.0" "134.9" "163.4" "158.9" "139.6" "147.3" "" "" "" "" "" "" "" "" "" "" "133.6" "128.2" "91.2" "97.0" "148.5" "115.1" "138.6" "115.0" "94.2" "147.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3793795971274937654" "False" "High" "IsMasterProtein" "Q96S59" "Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1" "0.000" "False" "18.989" "5" "3" "4" "3" "729" "77.8" "6.79" "13.65" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00622, Pf08513, Pf10607" "10048" "ENSG00000010017" "RANBP9" "A0PJA2; B2R8E1; hsa:10048; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; Q96S59" "RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape" "5" "0" "1.021" "0.825" "1.157" "1.060" "0.777" "0.940" "0.841" "0.840" "1.206" "78.2" "79.8" "64.5" "90.5" "82.9" "60.7" "73.5" "65.8" "65.7" "94.3" "" "" "" "" "" "" "" "" "" "" "70.6" "61.6" "49.9" "60.9" "69.1" "51.8" "62.4" "47.6" "44.3" "94.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-652499996560304904" "False" "High" "IsMasterProtein" "P32969" "Large ribosomal subunit protein uL6 OS=Homo sapiens OX=9606 GN=RPL9P9 PE=1 SV=1" "0.000" "False" "18.987" "23" "4" "9" "4" "192" "21.9" "9.95" "26.46" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "0.940" "0.924" "0.836" "1.004" "0.956" "0.831" "0.999" "0.984" "0.334" "139.4" "131.0" "128.8" "116.5" "140.0" "133.2" "115.9" "139.2" "137.2" "46.5" "" "" "" "" "" "" "" "" "" "" "125.8" "101.1" "99.6" "78.5" "116.8" "113.7" "98.3" "100.7" "92.5" "46.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4807008432777767819" "False" "High" "IsMasterProtein" "Q9NTZ6" "RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1" "0.000" "False" "18.986" "6" "5" "10" "5" "932" "97.3" "8.63" "21.93" "5" "other biological processes" "nucleus;other cell component" "" "Pf00076" "10137" "ENSG00000244462" "RBM12" "B3KRU2; E1P5R6; hsa:10137; O94865; Q8N3B1; Q9H196; Q9NTZ6" "" "" "0" "0" "0.939" "0.916" "1.031" "0.941" "1.003" "0.924" "0.937" "0.954" "2.352" "344.4" "323.6" "315.4" "355.1" "324.2" "345.4" "318.3" "322.7" "328.6" "810.1" "" "" "" "" "" "" "" "" "" "" "310.9" "249.6" "243.9" "239.1" "270.5" "294.8" "270.0" "233.6" "221.6" "810.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-599104977835536313" "False" "High" "IsMasterProtein" "P28799" "Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2" "0.000" "False" "18.976" "10" "6" "6" "6" "593" "63.5" "6.83" "17.88" "6" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00396" "2896" "ENSG00000030582" "GRN" "D3DX55; hsa:2896; P23781; P23782; P23783; P23784; P28799; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0" "Neutrophil degranulation" "IL-18 signaling pathway" "2" "0" "0.948" "0.846" "0.916" "1.016" "0.861" "0.989" "1.093" "0.777" "0.666" "204.5" "193.9" "173.1" "187.3" "207.8" "176.0" "202.4" "223.5" "158.9" "136.2" "" "" "" "" "" "" "" "" "" "" "184.6" "149.6" "133.9" "126.2" "173.3" "150.2" "171.7" "161.8" "107.2" "136.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9207268972416967358" "False" "High" "IsMasterProtein" "O15066" "Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1" "0.000" "False" "18.966" "8" "6" "10" "5" "747" "85.1" "7.69" "20.81" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9371" "ENSG00000101350" "KIF3B" "B2RMP4; B4DSR5; E1P5M5; hsa:9371; O15066" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins" "" "5" "0" "1.065" "0.937" "0.946" "1.157" "1.092" "0.950" "1.029" "0.912" "1.242" "192.0" "204.6" "180.0" "181.7" "222.2" "209.7" "182.4" "197.6" "175.1" "238.5" "" "" "" "" "" "" "" "" "" "" "173.3" "157.8" "139.2" "122.4" "185.3" "178.9" "154.7" "143.0" "118.1" "238.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6603036499622523787" "False" "High" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "0.000" "False" "18.964" "15" "6" "7" "6" "368" "42.0" "8.63" "21.93" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "1.014" "0.929" "0.984" "1.154" "0.935" "1.033" "0.969" "1.060" "1.178" "368.9" "374.1" "342.7" "363.1" "425.8" "345.0" "381.0" "357.3" "391.1" "434.4" "" "" "" "" "" "" "" "" "" "" "333.0" "288.6" "265.1" "244.5" "355.2" "294.4" "323.2" "258.6" "263.8" "434.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5608231469546375684" "False" "High" "IsMasterProtein" "O00161" "Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1" "0.000" "False" "18.962" "24" "5" "7" "5" "211" "23.3" "5.01" "20.99" "5" "cell-cell signaling;cell organization and biogenesis;stress response;transport" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00835" "8773" "ENSG00000092531" "SNAP23" "hsa:8773; O00161; O00162; Q13602; Q6IAE3" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding" "Insulin signaling" "13" "0" "0.954" "0.822" "1.070" "0.984" "0.992" "0.930" "1.078" "0.885" "0.725" "59.2" "56.5" "48.7" "63.4" "58.3" "58.8" "55.1" "63.8" "52.4" "42.9" "" "" "" "" "" "" "" "" "" "" "53.5" "43.6" "37.7" "42.7" "48.6" "50.2" "46.7" "46.2" "35.3" "42.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9028171991778450679" "False" "High" "IsMasterProtein" "P27540" "Aryl hydrocarbon receptor nuclear translocator OS=Homo sapiens OX=9606 GN=ARNT PE=1 SV=1" "0.000" "False" "18.955" "6" "4" "5" "4" "789" "86.6" "6.54" "13.73" "4" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf14598" "405" "ENSG00000143437" "ARNT" "B2R9H1; C4AMA1; F8WAP6; hsa:405; P27540; Q59ED4; Q5QP39; Q8NDC7" "PPARA activates gene expression; NPAS4 regulates expression of target genes; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor" "Angiogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; 6q16 copy number variation" "16" "0" "0.987" "1.101" "1.009" "1.107" "0.995" "1.055" "1.079" "1.239" "0.925" "135.6" "133.8" "149.3" "136.9" "150.1" "134.9" "143.1" "146.3" "168.0" "125.4" "" "" "" "" "" "" "" "" "" "" "122.4" "103.2" "115.5" "92.2" "125.2" "115.1" "121.3" "105.9" "113.3" "125.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090563644210438212" "False" "High" "IsMasterProtein" "Q6V1X1" "Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1" "0.000" "False" "18.928" "5" "4" "5" "3" "898" "103.3" "5.80" "14.11" "4" "protein metabolism;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "54878" "ENSG00000074603" "DPP8" "hsa:54878; Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4" "" "" "0" "0" "1.043" "0.897" "1.134" "1.037" "0.877" "0.880" "1.103" "0.979" "0.845" "63.6" "66.4" "57.1" "72.1" "66.0" "55.8" "56.0" "70.2" "62.3" "53.8" "" "" "" "" "" "" "" "" "" "" "57.4" "51.2" "44.1" "48.6" "55.0" "47.6" "47.5" "50.8" "42.0" "53.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842637441270179392" "False" "High" "IsMasterProtein" "Q9BU76" "Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1" "0.000" "False" "18.897" "15" "3" "3" "3" "263" "29.4" "10.02" "10.69" "3" "" "non-structural extracellular;other cell component" "" "Pf10159" "79169" "ENSG00000143793" "MMTAG2" "hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76" "Neutrophil degranulation" "" "1" "0" "1.124" "1.754" "1.194" "1.053" "1.853" "1.186" "1.109" "1.817" "0.852" "144.9" "162.8" "254.1" "173.0" "152.5" "268.4" "171.8" "160.6" "263.2" "123.5" "" "" "" "" "" "" "" "" "" "" "130.8" "125.6" "196.5" "116.5" "127.2" "229.1" "145.7" "116.2" "177.5" "123.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620722506811584939" "False" "High" "IsMasterProtein" "Q96GG9" "DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1" "0.000" "False" "18.892" "15" "4" "6" "4" "259" "30.1" "5.34" "18.80" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "54165" "ENSG00000043093" "DCUN1D1" "B2RB37; hsa:54165; Q7L3G9; Q8TEX7; Q96GG9; Q9H6M1; Q9HCT3" "Neddylation" "" "1" "0" "1.063" "0.994" "1.064" "1.107" "1.107" "1.028" "1.183" "0.972" "0.837" "318.3" "338.4" "316.5" "338.8" "352.6" "352.5" "327.1" "376.6" "309.6" "266.5" "" "" "" "" "" "" "" "" "" "" "287.4" "261.0" "244.8" "228.1" "294.1" "300.9" "277.5" "272.5" "208.8" "266.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3854455294821174963" "False" "High" "IsMasterProtein" "Q969X6" "U3 small nucleolar RNA-associated protein 4 homolog OS=Homo sapiens OX=9606 GN=UTP4 PE=1 SV=1" "0.000" "False" "18.890" "5" "3" "7" "3" "686" "76.8" "8.85" "15.09" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "84916" "ENSG00000141076; ENSG00000262788" "UTP4" "hsa:84916; Q8NCD9; Q8TF14; Q969X6; Q96SP0; Q96SR9; Q96SZ9; Q96T13; Q9BWK6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.439" "0.838" "1.231" "1.174" "0.970" "1.203" "0.950" "1.020" "0.854" "91.2" "131.2" "76.4" "112.2" "107.1" "88.5" "109.7" "86.6" "93.0" "77.9" "" "" "" "" "" "" "" "" "" "" "82.3" "101.2" "59.1" "75.6" "89.3" "75.5" "93.1" "62.7" "62.7" "77.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3959098677357932626" "False" "High" "IsMasterProtein" "O43747" "AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5" "0.000" "False" "18.883" "7" "6" "7" "6" "822" "91.3" "6.80" "23.29" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01602, Pf02883" "164" "ENSG00000166747" "AP1G1" "hsa:164; O43747; O75709; O75842; Q9UG09; Q9Y3U4" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "0" "1.017" "1.161" "0.926" "0.955" "1.200" "0.960" "0.759" "1.227" "2.371" "279.0" "283.6" "323.8" "258.4" "266.6" "334.8" "267.7" "211.6" "342.5" "661.5" "" "" "" "" "" "" "" "" "" "" "251.8" "218.8" "250.4" "174.0" "222.4" "285.8" "227.1" "153.1" "231.0" "661.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7424972638177503000" "False" "High" "IsMasterProtein" "Q5T1C6" "Acyl-coenzyme A thioesterase THEM4 OS=Homo sapiens OX=9606 GN=THEM4 PE=1 SV=1" "0.000" "False" "18.838" "19" "4" "5" "4" "240" "27.1" "8.28" "16.41" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf03061" "117145" "ENSG00000159445" "THEM4" "B2RBX2; hsa:117145; Q5T1C6; Q96KR2" "Mitochondrial Fatty Acid Beta-Oxidation; CD28 dependent PI3K/Akt signaling; Activation of AKT2; VEGFR2 mediated vascular permeability; Negative regulation of the PI3K/AKT network" "PI3K-Akt signaling pathway" "7" "0" "1.006" "1.100" "0.930" "1.086" "1.117" "1.028" "1.082" "1.083" "0.748" "262.4" "263.9" "288.7" "244.1" "284.9" "293.0" "269.7" "284.0" "284.2" "196.4" "" "" "" "" "" "" "" "" "" "" "236.9" "203.6" "223.3" "164.4" "237.7" "250.1" "228.8" "205.5" "191.7" "196.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4854644692515831998" "False" "High" "IsMasterProtein" "Q86X76" "Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2" "0.000" "False" "18.785" "14" "5" "6" "5" "327" "35.9" "7.74" "20.25" "5" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00795" "4817" "ENSG00000158793" "NIT1" "B1AQP3; D3DVF4; hsa:4817; O76091; Q86X76" "" "" "0" "0" "0.962" "0.970" "0.902" "1.011" "1.053" "0.976" "0.978" "1.013" "0.720" "564.9" "543.7" "548.1" "509.4" "571.4" "594.9" "551.3" "552.6" "572.0" "407.0" "" "" "" "" "" "" "" "" "" "" "509.9" "419.4" "423.9" "343.0" "476.6" "507.7" "467.7" "399.9" "385.8" "407.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1987024820899376297" "False" "High" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "0.000" "False" "18.763" "36" "4" "8" "4" "123" "13.9" "5.52" "27.73" "4" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "1.008" "1.094" "1.071" "0.958" "1.107" "1.034" "0.939" "1.161" "0.992" "376.5" "379.6" "412.0" "403.3" "360.6" "416.9" "389.2" "353.7" "437.2" "373.7" "" "" "" "" "" "" "" "" "" "" "339.9" "292.8" "318.7" "271.6" "300.8" "355.9" "330.2" "256.0" "294.9" "373.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015398897820644174" "False" "High" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "0.000" "False" "18.754" "11" "5" "6" "5" "476" "54.4" "8.25" "18.22" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "18" "0" "0.774" "0.617" "0.872" "0.765" "0.613" "0.906" "0.807" "0.633" "0.775" "385.6" "298.4" "238.1" "336.2" "295.0" "236.4" "349.2" "311.3" "243.9" "298.9" "" "" "" "" "" "" "" "" "" "" "348.1" "230.2" "184.1" "226.4" "246.1" "201.8" "296.2" "225.3" "164.5" "298.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4427751732173954290" "False" "High" "IsMasterProtein" "Q99700" "Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2" "0.000" "False" "18.749" "5" "7" "9" "6" "1313" "140.2" "9.57" "25.99" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "6311" "ENSG00000204842" "ATXN2" "A6NLD4; hsa:6311; Q24JQ7; Q6ZQZ7; Q99493; Q99700" "" "Parkinson's disease pathway; EGF/EGFR signaling pathway" "2" "0" "1.068" "1.066" "1.039" "1.040" "1.063" "1.077" "1.087" "1.107" "0.989" "620.4" "662.3" "661.0" "644.6" "645.2" "659.7" "667.9" "674.4" "686.7" "613.3" "" "" "" "" "" "" "" "" "" "" "560.0" "510.9" "511.3" "434.1" "538.2" "563.0" "566.6" "488.1" "463.2" "613.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3889272514054364250" "False" "High" "IsMasterProtein" "O15541" "E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1" "0.000" "False" "18.742" "20" "5" "8" "5" "343" "38.8" "5.69" "20.69" "5" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00642, Pf13920" "7737" "ENSG00000125352" "RNF113A" "B2RBR7; hsa:7737; O15541" "mRNA Splicing - Major Pathway" "" "1" "0" "0.952" "0.983" "1.054" "0.948" "0.875" "0.971" "1.156" "0.958" "0.764" "332.7" "316.6" "327.1" "350.6" "315.5" "291.0" "323.0" "384.5" "318.7" "254.1" "" "" "" "" "" "" "" "" "" "" "300.3" "244.2" "253.0" "236.1" "263.2" "248.4" "274.0" "278.3" "214.9" "254.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6935074334363071802" "False" "High" "IsMasterProtein" "O00762" "Ubiquitin-conjugating enzyme E2 C OS=Homo sapiens OX=9606 GN=UBE2C PE=1 SV=1" "0.000" "False" "18.742" "23" "4" "7" "4" "179" "19.6" "7.37" "22.52" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "11065" "ENSG00000175063" "UBE2C" "A6NP33; E1P5N7; G3XAB7; hsa:11065; O00762" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Gastric cancer network 1; Gastric cancer network 2" "21" "0" "0.852" "0.617" "0.920" "0.978" "0.620" "1.028" "1.041" "0.605" "2.351" "241.8" "206.1" "149.3" "222.4" "236.4" "149.9" "248.7" "251.8" "146.3" "568.6" "" "" "" "" "" "" "" "" "" "" "218.3" "159.0" "115.5" "149.8" "197.2" "127.9" "211.0" "182.2" "98.7" "568.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7945437556686127836" "False" "High" "IsMasterProtein" "Q96GA3" "Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1" "0.000" "False" "18.701" "7" "3" "5" "3" "475" "54.8" "4.91" "18.26" "3" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04180" "84946" "ENSG00000135521" "LTV1" "hsa:84946; Q96GA3; Q96JX8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.090" "1.000" "1.007" "0.913" "1.001" "0.999" "1.028" "0.958" "1.256" "112.6" "122.8" "112.6" "113.4" "102.8" "112.7" "112.5" "115.8" "107.9" "141.4" "" "" "" "" "" "" "" "" "" "" "101.7" "94.7" "87.1" "76.4" "85.8" "96.2" "95.5" "83.8" "72.8" "141.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8347450561102329946" "False" "High" "IsMasterProtein" "Q96BZ4" "5'-3' exonuclease PLD4 OS=Homo sapiens OX=9606 GN=PLD4 PE=1 SV=2" "0.000" "False" "18.697" "10" "5" "6" "5" "506" "55.6" "8.35" "17.31" "5" "DNA metabolism;stress response;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13918" "122618" "ENSG00000166428" "PLD4" "hsa:122618; Q6UWD2; Q96BZ4" "Role of phospholipids in phagocytosis; Synthesis of PG; Synthesis of IP3 and IP4 in the cytosol" "" "3" "0" "1.014" "1.139" "1.073" "1.007" "1.046" "0.937" "1.048" "1.088" "0.788" "213.7" "216.6" "243.3" "229.3" "215.1" "223.5" "200.2" "224.0" "232.4" "168.3" "" "" "" "" "" "" "" "" "" "" "192.9" "167.0" "188.2" "154.4" "179.4" "190.8" "169.8" "162.1" "156.8" "168.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811509789942253503" "False" "High" "IsMasterProtein" "Q7Z6M1" "Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1" "0.000" "False" "18.687" "19" "6" "6" "6" "372" "40.5" "6.25" "18.86" "6" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01344, Pf07646, Pf13415" "10244" "ENSG00000136933" "RABEPK" "A8K403; hsa:10244; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q7Z6M1; Q86Y76; Q9BWB1" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.028" "0.945" "1.104" "0.917" "0.906" "0.950" "1.001" "0.913" "0.691" "280.9" "288.7" "265.6" "310.2" "257.5" "254.6" "266.8" "281.1" "256.4" "194.1" "" "" "" "" "" "" "" "" "" "" "253.6" "222.7" "205.4" "208.9" "214.8" "217.3" "226.3" "203.4" "172.9" "194.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "609844474726423505" "False" "High" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "0.000" "False" "18.684" "18" "3" "11" "3" "158" "18.0" "8.66" "35.21" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; P50550; P63279; Q15698; Q59GX1; Q86VB3" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of RNA binding proteins; Formation of Incision Complex in GG-NER; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Meiotic synapsis; PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "Androgen receptor signaling pathway; TGF-beta signaling pathway; TAR syndrome" "27" "0" "0.974" "0.953" "0.948" "0.974" "1.032" "0.968" "0.976" "0.915" "0.840" "953.2" "928.4" "908.6" "904.0" "928.8" "983.7" "922.3" "930.5" "872.7" "801.0" "" "" "" "" "" "" "" "" "" "" "860.5" "716.1" "702.8" "608.8" "774.8" "839.6" "782.4" "673.4" "588.6" "801.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7289415820017297402" "False" "High" "IsMasterProtein" "P82675" "Small ribosomal subunit protein uS5m OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2" "0.000" "False" "18.677" "11" "5" "5" "5" "430" "48.0" "9.92" "15.54" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00333, Pf03719, Pf21251" "64969" "ENSG00000144029" "MRPS5" "hsa:64969; P82675; Q4ZFY5; Q96LJ6; Q9BWI4; Q9BYC4" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.942" "0.797" "0.918" "0.972" "0.745" "0.893" "0.834" "0.755" "1.301" "386.9" "364.3" "308.4" "355.3" "376.0" "288.2" "345.6" "322.8" "292.1" "503.3" "" "" "" "" "" "" "" "" "" "" "349.2" "281.0" "238.5" "239.2" "313.6" "246.0" "293.2" "233.6" "197.0" "503.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "961314597478386434" "False" "High" "IsMasterProtein" "P57740" "Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1" "0.000" "False" "18.656" "6" "5" "5" "5" "925" "106.3" "5.43" "15.05" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04121" "57122" "ENSG00000111581" "NUP107" "B4DZ67; hsa:57122; P57740; Q6PJE1" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SUMOylation of chromatin organization proteins; HCMV Late Events; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "Gastric cancer network 1; Primary ovarian insufficiency" "37" "0" "0.989" "0.888" "0.978" "1.100" "0.809" "0.958" "1.027" "0.828" "1.018" "210.5" "208.1" "186.9" "205.9" "231.6" "170.3" "201.6" "216.1" "174.4" "214.4" "" "" "" "" "" "" "" "" "" "" "190.0" "160.5" "144.5" "138.7" "193.2" "145.4" "171.0" "156.4" "117.6" "214.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3107589471447250441" "False" "High" "IsMasterProtein" "Q9NV06" "DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2" "0.000" "False" "18.647" "11" "4" "5" "4" "445" "51.4" "9.19" "14.75" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04158, Pf08662" "25879" "ENSG00000164934" "DCAF13" "hsa:25879; Q3MII9; Q8NCH8; Q8TC51; Q96JY7; Q9NV06; Q9NZX3" "Neddylation; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "3" "0" "1.098" "0.984" "1.179" "1.060" "0.881" "1.125" "1.100" "1.043" "0.400" "139.5" "153.2" "137.2" "164.5" "147.8" "122.8" "156.9" "153.5" "145.5" "55.7" "" "" "" "" "" "" "" "" "" "" "125.9" "118.2" "106.1" "110.8" "123.3" "104.9" "133.1" "111.1" "98.1" "55.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530888468156294697" "False" "High" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "0.000" "False" "18.625" "11" "5" "5" "5" "588" "68.0" "7.33" "13.67" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.891" "1.084" "0.812" "0.866" "1.006" "0.876" "0.460" "1.059" "4.654" "165.5" "147.5" "179.4" "134.3" "143.2" "166.5" "145.0" "76.1" "175.2" "770.1" "" "" "" "" "" "" "" "" "" "" "149.4" "113.8" "138.8" "90.4" "119.5" "142.1" "123.0" "55.0" "118.2" "770.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8113893803591480288" "False" "High" "IsMasterProtein" "Cont_Q7Z794" "Keratin, type II cytoskeletal 1b OS=Homo sapiens OX=9606 GN=KRT77 PE=1 SV=3" "0.000" "True" "18.625" "7" "4" "7" "1" "578" "61.9" "5.99" "23.94" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "374454" "ENSG00000189182" "KRT77" "hsa:374454; Q7RTS8; Q7Z794" "Formation of the cornified envelope" "" "2" "0" "0.829" "0.887" "1.083" "1.031" "1.011" "0.948" "1.063" "0.906" "0.646" "110.3" "91.5" "97.9" "119.5" "113.8" "111.6" "104.6" "117.3" "99.9" "71.3" "" "" "" "" "" "" "" "" "" "" "99.6" "70.5" "75.7" "80.5" "94.9" "95.3" "88.7" "84.9" "67.4" "71.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289518910119416826" "False" "High" "IsMasterProtein" "P61966" "AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1" "0.000" "False" "18.617" "15" "2" "3" "1" "158" "18.7" "5.73" "12.38" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1174" "ENSG00000106367" "AP1S1" "B2R5D8; hsa:1174; P61966; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "0" "1.238" "1.337" "1.354" "0.851" "1.226" "0.966" "1.138" "1.278" "2.560" "45.0" "55.7" "60.1" "60.9" "38.3" "55.1" "43.5" "51.2" "57.5" "115.1" "" "" "" "" "" "" "" "" "" "" "40.6" "42.9" "46.5" "41.0" "31.9" "47.1" "36.9" "37.0" "38.8" "115.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3710113209643881705" "False" "High" "IsMasterProtein" "O75794" "Translation initiation factor eIF2 assembly protein OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1" "0.000" "False" "18.606" "8" "3" "5" "3" "336" "39.1" "4.81" "15.25" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "" "Pf07065" "8872" "ENSG00000151465" "CDC123" "A8JZZ7; hsa:8872; O75794; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9" "" "" "0" "0" "0.955" "0.971" "0.966" "0.992" "0.874" "1.134" "1.007" "0.745" "0.882" "129.0" "123.3" "125.3" "124.6" "128.0" "112.7" "146.3" "130.0" "96.1" "113.8" "" "" "" "" "" "" "" "" "" "" "116.5" "95.1" "96.9" "83.9" "106.8" "96.2" "124.1" "94.1" "64.8" "113.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505612402410571852" "False" "High" "IsMasterProtein" "P17900" "Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4" "0.000" "False" "18.581" "20" "5" "11" "5" "193" "20.8" "5.31" "30.73" "5" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf02221" "2760" "ENSG00000196743" "GM2A" "B2R699; D3DQH6; hsa:2760; P17900; Q14426; Q14428; Q6LBL5" "Neutrophil degranulation; Glycosphingolipid catabolism" "Degradation pathway of sphingolipids, including diseases" "3" "0" "0.918" "0.921" "0.932" "0.955" "0.992" "0.925" "1.021" "0.986" "0.729" "563.2" "516.9" "518.5" "525.1" "537.6" "558.6" "521.1" "574.9" "555.4" "410.3" "" "" "" "" "" "" "" "" "" "" "508.4" "398.7" "401.1" "353.6" "448.4" "476.8" "442.1" "416.0" "374.6" "410.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5023759696218809409" "False" "High" "IsMasterProtein" "Q7Z434" "Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2" "0.000" "False" "18.569" "9" "3" "3" "3" "540" "56.5" "5.52" "13.61" "3" "stress response;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16739" "57506" "ENSG00000088888" "MAVS" "A8K6X0; B2BD33; B2BD34; F5H6C8; hsa:57506; M1P2Z0; Q2HWT5; Q3I0Y2; Q5T7I6; Q7Z434; Q86VY7; Q9H1H3; Q9H4Y1; Q9H8D3; Q9ULE9" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; PKR-mediated signaling; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Ovarian tumor domain proteases" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "24" "0" "1.053" "1.551" "1.012" "1.182" "1.469" "1.035" "1.128" "1.355" "1.068" "61.8" "65.1" "95.9" "62.5" "73.0" "90.8" "64.0" "69.7" "83.7" "66.0" "" "" "" "" "" "" "" "" "" "" "55.8" "50.2" "74.2" "42.1" "60.9" "77.5" "54.3" "50.4" "56.5" "66.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-474422990152712875" "False" "High" "IsMasterProtein" "P61923" "Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1" "0.000" "False" "18.565" "23" "3" "7" "3" "177" "20.2" "4.81" "20.89" "3" "transport" "other membranes;cytosol;ER/Golgi" "" "Pf01217" "22818" "ENSG00000111481" "COPZ1" "B4DDX8; B4DHZ0; F8VS17; F8VWL5; hsa:22818; P61923; Q549N6; Q9Y3C3" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "1.011" "0.883" "0.904" "0.893" "0.963" "1.020" "0.968" "0.920" "0.824" "195.8" "198.0" "172.9" "177.1" "174.8" "188.6" "199.6" "189.5" "180.1" "161.4" "" "" "" "" "" "" "" "" "" "" "176.7" "152.7" "133.7" "119.3" "145.9" "161.0" "169.3" "137.1" "121.5" "161.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1560013588739463450" "False" "High" "IsMasterProtein" "Q9H7D7" "WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3" "0.000" "False" "18.551" "4" "3" "3" "3" "661" "72.1" "6.16" "11.79" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400, Pf17814" "80232" "ENSG00000162923" "WDR26" "A0MNN3; hsa:80232; Q4G100; Q59EC4; Q5GLZ9; Q86UY4; Q9H3C2; Q9H7D7" "" "Ciliary landscape" "1" "0" "0.960" "0.756" "0.940" "0.861" "0.733" "1.020" "0.952" "0.834" "1.268" "266.4" "255.7" "201.5" "250.4" "229.3" "195.1" "271.8" "253.6" "222.1" "337.7" "" "" "" "" "" "" "" "" "" "" "240.5" "197.3" "155.9" "168.6" "191.3" "166.6" "230.6" "183.6" "149.8" "337.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340038753290804182" "False" "High" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "0.000" "False" "18.533" "4" "4" "4" "4" "1047" "119.8" "5.66" "12.88" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826, Pf21091" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "" "12" "0" "1.018" "1.378" "1.042" "0.916" "1.325" "0.978" "0.753" "1.314" "3.936" "205.5" "209.2" "283.2" "214.2" "188.3" "272.3" "201.1" "154.8" "270.0" "809.0" "" "" "" "" "" "" "" "" "" "" "185.5" "161.4" "219.0" "144.3" "157.0" "232.4" "170.6" "112.0" "182.1" "809.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5779519367271372583" "False" "High" "IsMasterProtein" "Q15645" "Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2" "0.000" "False" "18.505" "9" "4" "5" "4" "432" "48.5" "6.09" "13.93" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004" "9319" "ENSG00000071539" "TRIP13" "C9K0T3; D3DTC0; hsa:9319; O15324; Q15645" "" "Male infertility" "1" "0" "1.122" "0.759" "1.209" "1.182" "0.918" "1.120" "1.072" "0.886" "1.076" "197.9" "222.0" "150.3" "239.2" "233.9" "181.6" "221.6" "212.0" "175.2" "213.0" "" "" "" "" "" "" "" "" "" "" "178.6" "171.2" "116.2" "161.1" "195.1" "155.0" "188.0" "153.5" "118.2" "213.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915222884888566270" "False" "High" "IsMasterProtein" "O15020" "Spectrin beta chain, non-erythrocytic 2 OS=Homo sapiens OX=9606 GN=SPTBN2 PE=1 SV=3" "0.000" "False" "18.503" "2" "5" "5" "2" "2390" "271.2" "6.11" "18.11" "5" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf15410" "6712" "ENSG00000173898" "SPTBN2" "hsa:6712; O14872; O14873; O15020" "MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins" "" "5" "0" "0.926" "0.938" "1.081" "0.964" "0.949" "0.977" "0.876" "1.014" "3.568" "212.3" "196.5" "199.2" "229.5" "204.6" "201.6" "207.4" "186.1" "215.3" "757.7" "" "" "" "" "" "" "" "" "" "" "191.7" "151.6" "154.0" "154.6" "170.7" "172.1" "175.9" "134.7" "145.2" "757.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "916743004623214960" "False" "High" "IsMasterProtein" "P62266" "Small ribosomal subunit protein uS12 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "0.000" "False" "18.468" "21" "3" "4" "3" "143" "15.8" "10.49" "14.98" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "20" "0" "0.981" "1.023" "0.979" "0.917" "0.966" "1.137" "1.027" "0.876" "0.696" "306.3" "300.4" "313.4" "299.9" "280.8" "295.8" "348.2" "314.5" "268.4" "213.2" "" "" "" "" "" "" "" "" "" "" "276.5" "231.7" "242.4" "201.9" "234.2" "252.5" "295.4" "227.6" "181.0" "213.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3788247885213699411" "False" "High" "IsMasterProtein" "P04233" "HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3" "0.000" "False" "18.450" "13" "3" "4" "3" "296" "33.5" "8.44" "10.49" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf08831, Pf09307" "972" "ENSG00000019582" "CD74" "A8K7R1; B4DNE8; D3DQG3; D3DQG4; hsa:972; P04233; Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6" "MHC class II antigen presentation; Cell surface interactions at the vascular wall" "Macrophage markers" "3" "0" "1.072" "0.948" "1.108" "1.064" "0.923" "1.009" "0.766" "0.910" "0.809" "29.9" "32.0" "28.3" "33.1" "31.8" "27.6" "30.2" "22.9" "27.2" "24.2" "" "" "" "" "" "" "" "" "" "" "27.0" "24.7" "21.9" "22.3" "26.6" "23.6" "25.6" "16.6" "18.4" "24.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7294352330531963904" "False" "High" "IsMasterProtein" "Q99439" "Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4" "0.000" "False" "18.431" "7" "2" "3" "1" "309" "33.7" "7.33" "12.21" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00402" "1265" "ENSG00000064666" "CNN2" "A5D8U8; A6NFI4; D6W5X9; hsa:1265; Q92578; Q99439" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Myometrial relaxation and contraction pathways; Burn wound healing" "4" "1" "0.910" "0.908" "0.993" "0.872" "1.016" "0.924" "0.905" "0.977" "2.480" "318.4" "289.9" "289.2" "316.2" "277.6" "323.5" "294.3" "288.3" "311.1" "789.7" "" "" "" "" "" "" "" "" "" "" "287.4" "223.6" "223.7" "212.9" "231.5" "276.1" "249.6" "208.6" "209.8" "789.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072091565905259276" "False" "High" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "0.000" "False" "18.407" "13" "4" "9" "3" "277" "31.6" "6.54" "34.65" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "Caspase-mediated cleavage of cytoskeletal proteins; Other interleukin signaling; Degradation of the extracellular matrix; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; NADE modulates death signalling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "60" "0" "0.988" "0.863" "1.109" "1.005" "0.907" "1.076" "0.999" "0.980" "0.719" "739.5" "730.8" "638.1" "820.0" "743.5" "670.5" "796.0" "739.1" "724.7" "531.9" "" "" "" "" "" "" "" "" "" "" "667.5" "563.7" "493.5" "552.2" "620.2" "572.2" "675.2" "534.9" "488.8" "531.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7819708601940239359" "False" "High" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "0.000" "False" "18.386" "14" "4" "4" "4" "323" "37.6" "7.15" "13.49" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "39" "0" "1.026" "0.933" "0.969" "1.054" "0.889" "0.960" "0.945" "0.941" "1.150" "181.2" "185.9" "169.1" "175.6" "191.0" "161.0" "174.0" "171.3" "170.5" "208.4" "" "" "" "" "" "" "" "" "" "" "163.6" "143.4" "130.8" "118.2" "159.4" "137.4" "147.6" "124.0" "115.0" "208.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8357658854123366068" "False" "High" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "0.000" "False" "18.375" "8" "4" "4" "2" "521" "57.9" "4.96" "15.49" "4" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "Leptin signaling pathway" "3" "0" "1.514" "1.283" "1.356" "1.451" "1.201" "1.494" "1.520" "0.937" "1.239" "19.7" "29.8" "25.2" "26.7" "28.5" "23.6" "29.4" "29.9" "18.4" "24.4" "" "" "" "" "" "" "" "" "" "" "17.7" "23.0" "19.5" "17.9" "23.8" "20.1" "24.9" "21.6" "12.4" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7993967056221403717" "False" "High" "IsMasterProtein" "Q9BU02" "Thiamine-triphosphatase OS=Homo sapiens OX=9606 GN=THTPA PE=1 SV=3" "0.000" "False" "18.363" "25" "5" "7" "5" "230" "25.6" "4.82" "18.10" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf01928" "79178" "ENSG00000259431" "THTPA" "D3DS50; G3V4J3; hsa:79178; Q9BU02" "Vitamin B1 (thiamin) metabolism" "" "1" "0" "1.087" "0.787" "1.090" "0.922" "0.990" "0.990" "1.066" "0.838" "0.905" "64.5" "70.1" "50.8" "70.4" "59.5" "63.9" "63.9" "68.8" "54.1" "58.4" "" "" "" "" "" "" "" "" "" "" "58.3" "54.1" "39.3" "47.4" "49.6" "54.5" "54.2" "49.8" "36.5" "58.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5319872679741064952" "False" "High" "IsMasterProtein" "P22570" "NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3" "0.000" "False" "18.351" "13" "6" "7" "6" "491" "53.8" "8.44" "21.45" "6" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "2232" "ENSG00000161513" "FDXR" "B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; hsa:2232; P22570; Q13716; Q4PJI0; Q9BU12" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "Iron-sulfur cluster biogenesis" "5" "0" "1.192" "1.086" "1.046" "1.095" "1.085" "1.144" "1.123" "1.169" "1.962" "392.5" "467.9" "426.4" "410.6" "429.6" "425.9" "448.9" "440.6" "458.8" "769.9" "" "" "" "" "" "" "" "" "" "" "354.3" "360.9" "329.8" "276.5" "358.3" "363.5" "380.8" "318.9" "309.4" "769.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3114366665604462397" "False" "High" "IsMasterProtein" "Q9BZE2" "tRNA pseudouridine(38/39) synthase OS=Homo sapiens OX=9606 GN=PUS3 PE=1 SV=3" "0.000" "False" "18.347" "10" "5" "6" "5" "481" "55.6" "7.49" "21.03" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "83480" "ENSG00000110060" "PUS3" "B2RAM0; hsa:83480; Q96D17; Q96J23; Q96NB4; Q9BZE2" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.072" "0.940" "1.067" "1.015" "0.959" "1.046" "0.983" "0.984" "0.851" "478.7" "513.2" "449.9" "510.6" "486.0" "459.1" "500.6" "470.5" "471.2" "407.5" "" "" "" "" "" "" "" "" "" "" "432.1" "395.8" "348.0" "343.9" "405.4" "391.8" "424.6" "340.5" "317.8" "407.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3133917976218081073" "False" "High" "IsMasterProtein" "Q9Y3D8" "Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1" "0.000" "False" "18.347" "28" "4" "4" "4" "172" "20.0" "4.58" "13.14" "4" "other metabolic processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf13238" "102157402" "ENSG00000085231; ENSG00000279247" "AK6" "A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8" "Interconversion of nucleotide di- and triphosphates" "" "1" "0" "1.129" "1.102" "1.045" "1.055" "0.926" "1.088" "0.534" "1.071" "7.383" "223.2" "252.0" "246.1" "233.4" "235.6" "206.8" "242.9" "119.1" "239.0" "1648.2" "" "" "" "" "" "" "" "" "" "" "201.5" "194.4" "190.3" "157.2" "196.5" "176.5" "206.1" "86.2" "161.2" "1648.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3548704678811192106" "False" "High" "IsMasterProtein" "Q8ND30" "Liprin-beta-2 OS=Homo sapiens OX=9606 GN=PPFIBP2 PE=1 SV=3" "0.000" "False" "18.333" "6" "5" "5" "5" "876" "98.5" "6.27" "16.62" "5" "cell organization and biogenesis" "cytosol;other cell component" "other molecular function" "Pf00536, Pf07647" "8495" "ENSG00000166387" "PPFIBP2" "B7Z433; E9PK77; hsa:8495; O75337; Q8ND30; Q8WW26" "Receptor-type tyrosine-protein phosphatases" "Ectoderm differentiation" "2" "0" "0.859" "0.832" "0.989" "1.063" "0.710" "0.928" "0.789" "0.841" "1.378" "86.3" "74.1" "71.8" "85.3" "91.7" "61.2" "80.1" "68.0" "72.5" "118.8" "" "" "" "" "" "" "" "" "" "" "77.9" "57.1" "55.5" "57.5" "76.5" "52.3" "67.9" "49.2" "48.9" "118.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825408205880823904" "False" "High" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "0.000" "False" "18.314" "11" "5" "6" "5" "433" "48.3" "7.47" "20.18" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Nuclear events stimulated by ALK signaling in cancer; Phosphorylation of Emi1" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; IL-19 signaling pathway; DNA damage response" "33" "0" "1.028" "0.957" "0.999" "1.006" "0.946" "1.081" "1.034" "0.980" "0.870" "480.6" "493.9" "459.9" "480.4" "483.6" "454.9" "519.7" "497.0" "471.2" "418.3" "" "" "" "" "" "" "" "" "" "" "433.9" "381.0" "355.7" "323.5" "403.4" "388.2" "440.9" "359.7" "317.8" "418.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1949176893953303809" "False" "High" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "0.000" "False" "18.310" "18" "3" "5" "3" "219" "24.6" "4.83" "15.80" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "Ferroptosis" "3" "0" "0.954" "0.914" "0.991" "1.003" "0.900" "0.954" "1.095" "0.928" "0.665" "401.7" "383.2" "367.2" "397.9" "403.1" "361.5" "383.3" "439.8" "372.9" "267.3" "" "" "" "" "" "" "" "" "" "" "362.6" "295.6" "284.0" "268.0" "336.2" "308.5" "325.1" "318.3" "251.5" "267.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2447610796588384838" "False" "High" "IsMasterProtein" "Q96SZ5" "2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2" "0.000" "False" "18.309" "16" "5" "7" "5" "270" "29.7" "6.04" "22.94" "5" "stress response" "cytosol" "other molecular function" "Pf07847" "84890" "ENSG00000181915" "ADO" "B1AL29; hsa:84890; Q96SZ5" "Degradation of cysteine and homocysteine" "" "1" "0" "1.053" "0.994" "1.100" "1.060" "1.016" "1.059" "0.990" "0.995" "0.898" "627.9" "661.2" "624.2" "690.8" "665.3" "638.0" "664.7" "621.4" "624.6" "563.6" "" "" "" "" "" "" "" "" "" "" "566.8" "510.0" "482.8" "465.2" "555.0" "544.5" "563.9" "449.7" "421.3" "563.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629254407620291846" "False" "High" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "0.000" "False" "18.303" "7" "3" "6" "3" "464" "49.2" "9.64" "18.79" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.963" "1.286" "0.987" "1.016" "1.193" "0.927" "0.893" "1.163" "1.462" "272.3" "262.2" "350.3" "268.9" "276.8" "324.9" "252.3" "243.1" "316.8" "398.1" "" "" "" "" "" "" "" "" "" "" "245.8" "202.3" "271.0" "181.1" "230.9" "277.3" "214.0" "175.9" "213.7" "398.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2207555378581959897" "False" "High" "IsMasterProtein" "Q14761" "Protein tyrosine phosphatase receptor type C-associated protein OS=Homo sapiens OX=9606 GN=PTPRCAP PE=1 SV=1" "0.000" "False" "18.297" "21" "4" "5" "4" "206" "21.2" "4.55" "15.51" "4" "stress response" "plasma membrane;other membranes" "" "Pf15713" "5790" "ENSG00000213402" "PTPRCAP" "B2R512; hsa:5790; O00643; Q14761; Q6I9S6" "" "TNF-alpha signaling pathway" "1" "0" "1.230" "0.988" "1.141" "1.094" "0.964" "1.138" "1.079" "0.924" "0.948" "168.4" "207.1" "166.4" "192.3" "184.3" "162.4" "191.7" "181.7" "155.7" "159.7" "" "" "" "" "" "" "" "" "" "" "152.1" "159.8" "128.7" "129.5" "153.7" "138.6" "162.6" "131.5" "105.0" "159.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1080022240978719765" "False" "High" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "0.000" "False" "18.290" "16" "4" "13" "4" "201" "22.8" "7.02" "34.84" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "62" "0" "0.940" "1.054" "0.992" "1.010" "1.076" "0.978" "0.964" "1.103" "0.750" "1058.5" "994.7" "1115.3" "1050.1" "1068.6" "1138.9" "1035.7" "1020.5" "1167.6" "793.7" "" "" "" "" "" "" "" "" "" "" "955.5" "767.3" "862.6" "707.1" "891.4" "972.1" "878.6" "738.5" "787.5" "793.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3180744532399736086" "False" "High" "IsMasterProtein" "Q15814" "Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2" "0.000" "False" "18.248" "19" "8" "8" "7" "346" "39.2" "5.71" "23.78" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07986, Pf16752" "6903" "ENSG00000124659" "TBCC" "hsa:6903; Q15814; Q53Y43; Q5T787" "Post-chaperonin tubulin folding pathway" "" "1" "0" "0.909" "0.922" "0.981" "1.026" "0.925" "0.969" "0.939" "0.845" "0.846" "567.0" "515.2" "522.8" "556.2" "581.6" "524.7" "549.5" "532.6" "479.2" "479.7" "" "" "" "" "" "" "" "" "" "" "511.8" "397.4" "404.3" "374.6" "485.2" "447.8" "466.1" "385.4" "323.2" "479.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2170038667873591835" "False" "High" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "0.000" "False" "18.226" "2" "4" "5" "4" "2357" "251.7" "5.80" "17.09" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "COPII-mediated vesicle transport" "" "1" "0" "0.998" "1.572" "1.181" "1.137" "1.633" "1.172" "1.159" "1.559" "1.933" "262.3" "261.9" "412.2" "309.7" "298.3" "428.4" "307.5" "304.1" "408.8" "507.0" "" "" "" "" "" "" "" "" "" "" "236.7" "202.0" "318.8" "208.5" "248.8" "365.6" "260.8" "220.1" "275.7" "507.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4005780129157962021" "False" "High" "IsMasterProtein" "Q9BUR4" "Telomerase Cajal body protein 1 OS=Homo sapiens OX=9606 GN=WRAP53 PE=1 SV=1" "0.000" "False" "18.192" "9" "4" "5" "4" "548" "59.3" "4.58" "15.75" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "55135" "ENSG00000141499" "WRAP53" "B3KPR9; D3DTQ4; hsa:55135; Q08ET9; Q9BUR4; Q9NW09" "Association of TriC/CCT with target proteins during biosynthesis; Telomere Extension By Telomerase" "" "2" "0" "1.003" "1.049" "1.040" "0.983" "1.203" "1.055" "0.836" "0.952" "0.767" "79.2" "79.4" "83.1" "82.4" "77.9" "95.3" "83.6" "66.3" "75.4" "60.7" "" "" "" "" "" "" "" "" "" "" "71.5" "61.3" "64.3" "55.5" "65.0" "81.4" "70.9" "47.9" "50.9" "60.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2771631356277906494" "False" "High" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "0.000" "False" "18.183" "6" "2" "3" "2" "507" "55.0" "7.72" "13.25" "2" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Basigin interactions; Tryptophan catabolism; Amino acid transport across the plasma membrane" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "7" "0" "1.005" "0.799" "1.037" "0.894" "0.692" "0.953" "0.887" "0.879" "0.588" "200.1" "201.1" "159.8" "207.4" "178.9" "138.4" "190.6" "177.4" "175.8" "117.7" "" "" "" "" "" "" "" "" "" "" "180.6" "155.1" "123.6" "139.7" "149.2" "118.1" "161.7" "128.4" "118.6" "117.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4314325281228425264" "False" "High" "IsMasterProtein" "O15382" "Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2" "0.000" "False" "18.181" "11" "4" "5" "4" "392" "44.3" "8.65" "16.86" "4" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01063" "587" "ENSG00000105552" "BCAT2" "B2RB87; hsa:587; O00269; O15382; Q96KG1; Q9BTB6; Q9BUU6" "Branched-chain amino acid catabolism" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "3" "0" "0.956" "0.764" "0.897" "0.939" "1.037" "0.909" "0.908" "1.029" "0.795" "91.2" "87.1" "69.7" "81.8" "85.7" "94.6" "82.9" "82.8" "93.9" "72.5" "" "" "" "" "" "" "" "" "" "" "82.3" "67.2" "53.9" "55.1" "71.5" "80.7" "70.3" "59.9" "63.3" "72.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5753903603639706733" "False" "High" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0.000" "False" "18.118" "3" "5" "6" "5" "1401" "157.1" "6.61" "16.44" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "Condensation of Prometaphase Chromosomes" "" "1" "0" "1.124" "0.730" "0.831" "0.701" "0.655" "0.920" "0.778" "0.720" "1.671" "24.0" "27.0" "17.6" "20.0" "16.9" "15.8" "22.1" "18.7" "17.3" "40.2" "" "" "" "" "" "" "" "" "" "" "21.7" "20.8" "13.6" "13.5" "14.1" "13.5" "18.8" "13.5" "11.7" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3972038562420252503" "False" "High" "IsMasterProtein" "P61254" "Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "0.000" "False" "18.079" "29" "6" "9" "6" "145" "17.2" "10.55" "25.04" "6" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "Regulation of expression of SLITs and ROBOs; Peptide chain elongation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.884" "1.079" "0.860" "1.038" "0.977" "1.027" "1.099" "1.031" "0.455" "376.1" "332.5" "405.6" "323.4" "390.3" "367.3" "386.3" "413.4" "387.7" "171.0" "" "" "" "" "" "" "" "" "" "" "339.5" "256.4" "313.7" "217.8" "325.6" "313.5" "327.7" "299.1" "261.5" "171.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4563498728879559184" "False" "High" "IsMasterProtein" "Q9BW71" "HIRA-interacting protein 3 OS=Homo sapiens OX=9606 GN=HIRIP3 PE=1 SV=3" "0.000" "False" "18.073" "11" "6" "9" "6" "556" "61.9" "8.54" "20.31" "6" "cell organization and biogenesis" "nucleus" "" "Pf09649" "8479" "ENSG00000149929" "HIRIP3" "H3BSR3; hsa:8479; O75707; O75708; Q9BW71" "" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "2" "0" "0.985" "1.038" "1.021" "0.941" "1.020" "0.928" "1.007" "1.149" "0.741" "409.7" "403.7" "425.2" "418.2" "385.6" "417.9" "380.1" "412.4" "470.9" "303.5" "" "" "" "" "" "" "" "" "" "" "369.8" "311.4" "328.9" "281.6" "321.7" "356.7" "322.4" "298.4" "317.6" "303.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7869799461247912985" "False" "High" "IsMasterProtein" "Q96GW9" "Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2" "0.000" "False" "18.070" "10" "6" "6" "6" "593" "66.5" "8.09" "16.95" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf09334, Pf19303" "92935" "ENSG00000247626" "MARS2" "A0AVC3; hsa:92935; Q76E79; Q8IW62; Q8N7N4; Q96GW9" "Mitochondrial tRNA aminoacylation" "Amino acid metabolism" "2" "0" "1.012" "0.946" "1.053" "1.040" "1.035" "1.013" "0.964" "1.153" "0.655" "239.3" "242.1" "226.3" "252.0" "248.9" "247.7" "242.5" "230.7" "275.9" "156.7" "" "" "" "" "" "" "" "" "" "" "216.0" "186.8" "175.0" "169.7" "207.6" "211.4" "205.7" "167.0" "186.1" "156.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4024286234021820395" "False" "High" "IsMasterProtein" "P78406" "mRNA export factor RAE1 OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "0.000" "False" "18.065" "9" "3" "4" "3" "368" "40.9" "7.83" "13.06" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Regulation of HSF1-mediated heat shock response; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "30" "0" "0.841" "0.904" "0.966" "0.927" "1.002" "0.709" "0.767" "1.027" "1.249" "48.9" "41.1" "44.2" "47.2" "45.3" "49.0" "34.6" "37.5" "50.2" "61.0" "" "" "" "" "" "" "" "" "" "" "44.1" "31.7" "34.2" "31.8" "37.8" "41.8" "29.4" "27.1" "33.9" "61.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549741875275556482" "False" "High" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "0.000" "False" "18.050" "24" "3" "7" "3" "209" "23.2" "5.38" "17.15" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Neddylation; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "Ciliary landscape; 2q37 copy number variation syndrome" "6" "0" "0.984" "0.791" "0.930" "0.935" "0.979" "0.929" "0.905" "1.015" "0.945" "258.7" "254.6" "204.6" "240.4" "241.8" "253.3" "240.4" "234.1" "262.5" "244.5" "" "" "" "" "" "" "" "" "" "" "233.5" "196.4" "158.2" "161.9" "201.7" "216.2" "203.9" "169.4" "177.1" "244.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6077742637667714135" "False" "High" "IsMasterProtein" "Q00535" "Cyclin-dependent kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3" "0.000" "False" "18.036" "14" "4" "9" "3" "292" "33.3" "7.66" "26.93" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1020" "ENSG00000164885" "CDK5" "A1XKG3; hsa:1020; Q00535" "NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; DARPP-32 events; Activated NTRK2 signals through CDK5" "miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "16" "0" "1.124" "0.980" "1.037" "1.096" "0.932" "1.255" "1.086" "1.038" "1.438" "110.2" "123.9" "108.0" "114.3" "120.8" "102.7" "138.3" "119.7" "114.4" "158.6" "" "" "" "" "" "" "" "" "" "" "99.5" "95.6" "83.6" "77.0" "100.8" "87.7" "117.3" "86.6" "77.2" "158.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-994823259514569156" "False" "High" "IsMasterProtein" "Q96I59" "Asparaginyl-tRNA synthetase OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3" "0.000" "False" "18.010" "9" "5" "5" "5" "477" "54.1" "7.24" "15.99" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "79731" "ENSG00000137513" "NARS2" "G3V178; hsa:79731; Q96I59" "Mitochondrial tRNA aminoacylation" "Ectoderm differentiation" "2" "0" "1.037" "0.858" "0.932" "1.099" "0.839" "1.083" "1.118" "0.888" "1.036" "488.9" "507.0" "419.6" "455.6" "537.1" "410.0" "529.7" "546.6" "434.1" "506.6" "" "" "" "" "" "" "" "" "" "" "441.3" "391.1" "324.5" "306.8" "448.0" "350.0" "449.3" "395.6" "292.8" "506.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7643769137675685694" "False" "High" "IsMasterProtein" "P82933" "Small ribosomal subunit protein uS9m OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" "0.000" "False" "18.001" "13" "5" "5" "5" "396" "45.8" "9.51" "18.94" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00380" "64965" "ENSG00000135972" "MRPS9" "hsa:64965; P82933; Q6PG40" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.974" "0.810" "0.913" "1.050" "0.800" "0.955" "0.898" "0.849" "1.453" "423.0" "411.9" "342.7" "386.0" "444.1" "338.5" "404.0" "379.9" "359.1" "614.5" "" "" "" "" "" "" "" "" "" "" "381.8" "317.7" "265.1" "259.9" "370.4" "288.9" "342.7" "274.9" "242.2" "614.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1788576308263676540" "False" "High" "IsMasterProtein" "Q9BUK6" "Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1" "0.000" "False" "17.998" "7" "4" "6" "4" "570" "61.8" "6.11" "16.77" "4" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion;other cell component" "" "Pf10644, Pf14881" "55154" "ENSG00000125459" "MSTO1" "hsa:55154; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9BUK6; Q9NQX2; Q9NVU4" "" "" "0" "0" "0.997" "0.869" "1.058" "1.069" "0.908" "1.027" "1.120" "0.919" "1.058" "341.3" "340.4" "296.5" "361.1" "364.8" "309.8" "350.7" "382.2" "313.8" "361.1" "" "" "" "" "" "" "" "" "" "" "308.1" "262.5" "229.3" "243.2" "304.3" "264.4" "297.5" "276.6" "211.6" "361.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3867715510256549408" "False" "High" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "0.000" "False" "17.997" "7" "5" "5" "5" "651" "70.8" "8.51" "16.06" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "10" "0" "0.980" "0.953" "1.040" "1.077" "0.862" "1.044" "1.093" "0.900" "0.803" "388.7" "380.9" "370.4" "404.2" "418.6" "335.1" "406.0" "424.8" "349.7" "312.0" "" "" "" "" "" "" "" "" "" "" "350.9" "293.8" "286.5" "272.2" "349.2" "286.0" "344.4" "307.4" "235.9" "312.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3153714913884480543" "False" "High" "IsMasterProtein" "Q8TAE8" "Large ribosomal subunit protein mL64 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "0.000" "False" "17.951" "26" "4" "4" "4" "222" "25.4" "10.02" "12.97" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.091" "0.844" "1.016" "0.875" "1.129" "0.949" "1.041" "0.843" "0.850" "85.0" "92.7" "71.7" "86.3" "74.4" "95.9" "80.6" "88.4" "71.6" "72.2" "" "" "" "" "" "" "" "" "" "" "76.7" "71.5" "55.5" "58.1" "62.0" "81.9" "68.4" "64.0" "48.3" "72.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1217217274349295091" "False" "High" "IsMasterProtein" "Q9Y4E8" "Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3" "0.000" "False" "17.940" "5" "5" "6" "5" "981" "112.3" "5.22" "18.65" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "9958" "ENSG00000135655" "USP15" "hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5" "UCH proteinases; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7171410217774938332" "False" "High" "IsMasterProtein" "Q96T51" "RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2" "0.000" "False" "17.931" "6" "3" "3" "3" "708" "79.8" "5.74" "11.78" "3" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "80230" "ENSG00000176783; ENSG00000284260" "RUFY1" "hsa:80230; Q59FF3; Q71S93; Q96T51; Q9H6I3" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "1.047" "0.824" "1.078" "0.815" "0.795" "0.799" "0.927" "0.900" "2.656" "80.6" "84.3" "66.4" "86.8" "65.7" "64.1" "64.3" "74.7" "72.5" "213.9" "" "" "" "" "" "" "" "" "" "" "72.7" "65.1" "51.3" "58.5" "54.8" "54.7" "54.6" "54.0" "48.9" "213.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6373190460563601224" "False" "High" "IsMasterProtein" "Q7L014" "Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2" "0.000" "False" "17.890" "7" "6" "6" "6" "1031" "117.3" "9.29" "14.79" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus" "other molecular function" "Pf00270, Pf00271" "9879" "ENSG00000145833" "DDX46" "hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658" "mRNA Splicing - Major Pathway" "" "1" "0" "1.129" "0.909" "1.010" "1.077" "0.904" "1.008" "0.740" "0.995" "3.910" "100.0" "112.9" "91.0" "101.0" "107.8" "90.4" "100.8" "74.0" "99.5" "391.1" "" "" "" "" "" "" "" "" "" "" "90.3" "87.1" "70.4" "68.0" "89.9" "77.2" "85.5" "53.5" "67.1" "391.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6389747246599202641" "False" "High" "IsMasterProtein" "Q53SF7" "Cordon-bleu protein-like 1 OS=Homo sapiens OX=9606 GN=COBLL1 PE=1 SV=3" "0.000" "False" "17.886" "4" "4" "6" "4" "1128" "123.8" "6.58" "13.46" "4" "" "" "cytoskeletal activity" "Pf09469" "22837" "ENSG00000082438" "COBLL1" "A6NMZ3; hsa:22837; Q53SF7; Q6IQ33; Q7Z3I6; Q9BRH4; Q9UG88; Q9Y2I3" "" "" "0" "0" "0.968" "0.649" "0.739" "0.810" "0.937" "0.627" "0.789" "0.717" "1.037" "57.6" "55.7" "37.3" "42.5" "46.6" "53.9" "36.1" "45.4" "41.3" "59.7" "" "" "" "" "" "" "" "" "" "" "52.0" "43.0" "28.9" "28.7" "38.9" "46.0" "30.6" "32.9" "27.8" "59.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2344420003979128506" "False" "High" "IsMasterProtein" "O60449" "Lymphocyte antigen 75 OS=Homo sapiens OX=9606 GN=LY75 PE=1 SV=3" "0.000" "False" "17.871" "1" "1" "2" "1" "1722" "198.2" "6.67" "9.57" "1" "stress response;transport;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00040, Pf00059" "100526664; 4065" "ENSG00000054219" "LY75" "hsa:100526664; hsa:4065; O60449; O75913; Q53R46; Q53TF5; Q7Z575; Q7Z577" "" "" "0" "0" "0.927" "0.951" "0.981" "1.020" "0.950" "0.999" "1.104" "1.000" "0.838" "92.0" "85.3" "87.5" "90.2" "93.8" "87.4" "92.0" "101.6" "92.0" "77.1" "" "" "" "" "" "" "" "" "" "" "83.1" "65.8" "67.7" "60.8" "78.3" "74.6" "78.0" "73.6" "62.1" "77.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4752916691292977805" "False" "High" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "0.000" "False" "17.868" "7" "5" "5" "5" "778" "88.0" "6.80" "12.85" "5" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "0.989" "0.847" "0.922" "0.952" "0.875" "1.000" "0.956" "0.892" "1.550" "279.2" "276.1" "236.4" "257.5" "265.8" "244.4" "279.3" "267.0" "249.1" "432.9" "" "" "" "" "" "" "" "" "" "" "252.0" "213.0" "182.9" "173.4" "221.7" "208.6" "236.9" "193.2" "168.0" "432.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8196142567442196869" "False" "High" "IsMasterProtein" "P20645" "Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1" "0.000" "False" "17.842" "10" "2" "3" "2" "277" "31.0" "5.83" "12.25" "2" "transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02157" "4074" "ENSG00000003056" "M6PR" "A8K528; D3DUV5; hsa:4074; P20645" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Glycosphingolipid catabolism" "" "5" "0" "0.998" "0.989" "1.114" "0.951" "0.798" "0.972" "1.046" "0.915" "1.291" "114.7" "114.5" "113.5" "127.8" "109.1" "91.6" "111.5" "120.0" "105.0" "148.1" "" "" "" "" "" "" "" "" "" "" "103.6" "88.3" "87.8" "86.1" "91.0" "78.2" "94.6" "86.9" "70.8" "148.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-320392191251803943" "False" "High" "IsMasterProtein" "Q9BXS6" "Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1" "0.000" "False" "17.825" "10" "4" "5" "4" "441" "49.4" "9.91" "15.65" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf16006" "51203" "ENSG00000137804" "NUSAP1" "B4DDF1; E7ERR5; hsa:51203; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9BXS6; Q9GZM9; Q9NZ85; Q9UI70" "" "" "0" "0" "0.859" "0.704" "1.047" "0.826" "0.540" "0.818" "1.160" "0.374" "0.837" "26.2" "22.5" "18.4" "27.4" "21.6" "14.1" "21.4" "30.3" "9.8" "21.9" "" "" "" "" "" "" "" "" "" "" "23.6" "17.3" "14.3" "18.4" "18.0" "12.1" "18.2" "22.0" "6.6" "21.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8905060599663970094" "False" "High" "IsMasterProtein" "Q9Y5K8" "V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1" "0.000" "False" "17.816" "23" "5" "6" "5" "247" "28.2" "9.36" "16.09" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01813" "51382" "ENSG00000100554" "ATP6V1D" "B2RE33; hsa:51382; Q9Y5K8; Q9Y688" "Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "7" "0" "0.999" "0.904" "1.133" "1.159" "0.963" "1.148" "1.115" "0.952" "0.907" "86.0" "85.9" "77.8" "97.4" "99.7" "82.8" "98.7" "95.9" "81.9" "78.0" "" "" "" "" "" "" "" "" "" "" "77.6" "66.3" "60.1" "65.6" "83.2" "70.7" "83.8" "69.4" "55.2" "78.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447457189107336251" "False" "High" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "0.000" "False" "17.801" "30" "5" "6" "3" "162" "18.8" "8.66" "17.40" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "" "2" "1" "0.996" "0.982" "1.154" "1.133" "0.898" "1.180" "1.148" "1.004" "2.200" "170.1" "169.5" "167.1" "196.3" "192.8" "152.8" "200.8" "195.3" "170.8" "374.3" "" "" "" "" "" "" "" "" "" "" "153.6" "130.7" "129.3" "132.2" "160.8" "130.4" "170.3" "141.4" "115.2" "374.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3589965409300637784" "False" "High" "IsMasterProtein" "Q14691" "DNA replication complex GINS protein PSF1 OS=Homo sapiens OX=9606 GN=GINS1 PE=1 SV=1" "0.000" "False" "17.796" "23" "3" "4" "3" "196" "23.0" "7.39" "14.50" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf05916" "9837" "ENSG00000101003" "GINS1" "hsa:9837; Q14691; Q9NQE2; Q9NQI7" "Unwinding of DNA" "" "1" "0" "1.150" "1.104" "1.283" "1.189" "1.122" "1.354" "1.033" "1.188" "1.630" "91.8" "105.6" "101.4" "117.8" "109.2" "103.0" "124.4" "94.9" "109.1" "149.7" "" "" "" "" "" "" "" "" "" "" "82.9" "81.5" "78.4" "79.4" "91.1" "87.9" "105.5" "68.7" "73.6" "149.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4650231133703774819" "False" "High" "IsMasterProtein" "Q96RF0" "Sorting nexin-18 OS=Homo sapiens OX=9606 GN=SNX18 PE=1 SV=2" "0.000" "False" "17.772" "9" "5" "5" "5" "628" "68.9" "5.68" "14.49" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf10456, Pf14604" "112574" "ENSG00000178996" "SNX18" "B4E2B3; H7BXX3; hsa:112574; Q05BB3; Q0VG02; Q96RF0" "Clathrin-mediated endocytosis" "" "1" "0" "0.906" "1.001" "1.077" "1.002" "0.974" "0.973" "0.806" "1.007" "4.509" "229.5" "208.0" "229.7" "247.1" "229.9" "223.6" "223.2" "185.0" "231.1" "1034.9" "" "" "" "" "" "" "" "" "" "" "207.2" "160.5" "177.7" "166.4" "191.8" "190.9" "189.4" "133.9" "155.9" "1034.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3253297407861631258" "False" "High" "IsMasterProtein" "O95155" "Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1" "0.000" "False" "17.752" "5" "7" "7" "6" "1302" "146.1" "6.55" "18.45" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "10277" "ENSG00000130939" "UBE4B" "A8K8S9; G0ZJH6; O75169; O95155; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7" "" "" "0" "0" "0.932" "0.808" "1.234" "1.087" "0.818" "1.046" "1.095" "0.863" "1.004" "64.3" "60.0" "52.0" "79.4" "69.9" "52.7" "67.3" "70.4" "55.6" "64.6" "" "" "" "" "" "" "" "" "" "" "58.1" "46.3" "40.2" "53.5" "58.3" "44.9" "57.1" "51.0" "37.5" "64.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3076278996676727483" "False" "High" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "0.000" "False" "17.721" "8" "5" "6" "5" "603" "68.2" "8.91" "17.10" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "The role of GTSE1 in G2/M progression after G2 checkpoint; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Mitotic Telophase/Cytokinesis; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1566902771694482530" "False" "High" "IsMasterProtein" "P51153" "Ras-related protein Rab-13 OS=Homo sapiens OX=9606 GN=RAB13 PE=1 SV=1" "0.000" "False" "17.717" "17" "4" "7" "1" "203" "22.8" "9.19" "22.21" "4" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5872" "ENSG00000143545" "RAB13" "A8K6B5; D3DV67; hsa:5872; P51153; Q5U0A6; Q6GPG6; Q96GU4" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane" "Leukocyte-intrinsic Hippo pathway functions" "4" "0" "0.910" "0.883" "0.692" "1.009" "0.939" "0.995" "1.046" "0.760" "0.786" "41.3" "37.6" "36.5" "28.6" "41.7" "38.8" "41.1" "43.3" "31.4" "32.5" "" "" "" "" "" "" "" "" "" "" "37.3" "29.0" "28.2" "19.3" "34.8" "33.1" "34.9" "31.3" "21.2" "32.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386801928701098306" "False" "High" "IsMasterProtein" "Q6ULP2" "Aftiphilin OS=Homo sapiens OX=9606 GN=AFTPH PE=1 SV=3" "0.000" "False" "17.713" "6" "4" "4" "4" "936" "102.1" "4.54" "11.99" "4" "transport" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15045" "54812" "ENSG00000119844" "AFTPH" "D6W5E9; hsa:54812; Q6ULP2; Q6ZM66; Q86VW3; Q8TCF3; Q9H7E3; Q9HAB9; Q9NXS4" "" "" "0" "0" "1.163" "1.084" "1.071" "0.986" "0.958" "1.053" "1.118" "1.061" "1.024" "172.8" "201.0" "187.3" "185.1" "170.4" "165.6" "181.9" "193.2" "183.3" "177.0" "" "" "" "" "" "" "" "" "" "" "156.0" "155.1" "144.9" "124.6" "142.1" "141.3" "154.3" "139.8" "123.7" "177.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "376281410555249272" "False" "High" "IsMasterProtein" "O75592" "E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4" "0.000" "False" "17.707" "2" "8" "8" "8" "4678" "513.3" "7.02" "18.12" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf03256, Pf08005, Pf13540" "23077" "ENSG00000005810" "MYCBP2" "A6NJC6; O75592; Q5JSX8; Q5VZN6; Q6PIB6; Q9UQ11; Q9Y6E4" "" "3q29 copy number variation syndrome" "1" "0" "0.987" "1.002" "1.048" "1.010" "0.928" "0.984" "0.896" "1.032" "1.541" "312.4" "308.3" "313.1" "327.4" "315.5" "289.9" "307.5" "280.1" "322.3" "481.4" "" "" "" "" "" "" "" "" "" "" "282.0" "237.8" "242.2" "220.5" "263.1" "247.4" "260.9" "202.7" "217.4" "481.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4039607230823659526" "False" "High" "IsMasterProtein" "P42025" "Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1" "0.000" "False" "17.703" "11" "4" "5" "3" "376" "42.3" "6.40" "14.99" "4" "" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10120" "ENSG00000115073; ENSG00000291597" "ACTR1B" "D3DVH2; hsa:10120; P42025; Q53SK5; Q9BRB7" "Neutrophil degranulation; MHC class II antigen presentation" "" "2" "0" "0.859" "0.729" "1.272" "0.706" "0.994" "0.973" "0.816" "0.988" "0.737" "43.1" "37.0" "31.4" "54.8" "30.4" "42.8" "41.9" "35.1" "42.5" "31.7" "" "" "" "" "" "" "" "" "" "" "38.9" "28.5" "24.3" "36.9" "25.3" "36.5" "35.5" "25.4" "28.7" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2645630736488314632" "False" "High" "IsMasterProtein" "P04080" "Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2" "0.000" "False" "17.699" "24" "2" "3" "2" "98" "11.1" "7.56" "13.64" "2" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1476" "ENSG00000160213" "CSTB" "hsa:1476; P04080" "Neutrophil degranulation" "" "1" "0" "0.912" "1.088" "0.862" "1.029" "1.239" "0.836" "1.118" "1.058" "0.819" "150.1" "136.9" "163.3" "129.4" "154.4" "185.9" "125.5" "167.7" "158.8" "122.9" "" "" "" "" "" "" "" "" "" "" "135.5" "105.6" "126.3" "87.1" "128.8" "158.7" "106.4" "121.4" "107.1" "122.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4224605817431316350" "False" "High" "IsMasterProtein" "Q96ST2" "Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2" "0.000" "False" "17.687" "10" "7" "8" "7" "819" "91.9" "4.69" "20.96" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "" "Pf08711" "55677" "ENSG00000163166" "IWS1" "hsa:55677; Q2TB65; Q6P157; Q8N3E8; Q96MI7; Q96ST2; Q9NV97; Q9NWH8" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "" "3" "0" "0.959" "1.273" "1.006" "0.970" "1.218" "0.977" "0.886" "1.302" "1.936" "376.0" "360.4" "478.7" "378.2" "364.6" "457.8" "367.2" "333.1" "489.4" "728.0" "" "" "" "" "" "" "" "" "" "" "339.4" "278.0" "370.3" "254.7" "304.1" "390.7" "311.5" "241.1" "330.1" "728.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245532746290238029" "False" "High" "IsMasterProtein" "P61353" "Large ribosomal subunit protein eL27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2" "0.000" "False" "17.677" "36" "4" "7" "4" "136" "15.8" "10.56" "21.89" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00467, Pf01777" "6155" "ENSG00000131469" "RPL27" "hsa:6155; P08526; P61353; Q4G0A9" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "15" "0" "0.870" "1.073" "0.957" "0.953" "1.008" "0.962" "0.958" "1.011" "0.345" "527.7" "459.0" "566.3" "505.1" "502.7" "532.0" "507.6" "505.7" "533.2" "182.1" "" "" "" "" "" "" "" "" "" "" "476.3" "354.0" "438.0" "340.1" "419.3" "454.1" "430.6" "365.9" "359.7" "182.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2735556346422021928" "False" "High" "IsMasterProtein" "P53384" "Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2" "0.000" "False" "17.670" "20" "5" "7" "5" "320" "34.5" "5.33" "20.14" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "4682" "ENSG00000103274" "NUBP1" "hsa:4682; P53384; Q32M30; Q498A9; Q53FS7" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis" "2" "0" "0.915" "0.745" "1.121" "0.987" "0.933" "1.070" "0.802" "0.880" "0.767" "53.8" "49.2" "40.0" "60.3" "53.1" "50.2" "57.5" "43.1" "47.3" "41.2" "" "" "" "" "" "" "" "" "" "" "48.5" "37.9" "31.0" "40.6" "44.3" "42.8" "48.8" "31.2" "31.9" "41.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2821733550000515702" "False" "High" "IsMasterProtein" "Q9NX46" "ADP-ribosylhydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1" "0.000" "False" "17.634" "11" "3" "4" "3" "363" "38.9" "5.07" "14.97" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03747" "54936" "ENSG00000116863" "ADPRS" "hsa:54936; Q53G94; Q6IAB8; Q9BY47; Q9NX46" "POLB-Dependent Long Patch Base Excision Repair" "" "1" "0" "0.949" "1.083" "0.808" "1.165" "1.020" "1.166" "1.081" "0.988" "1.025" "95.7" "90.8" "103.7" "77.3" "111.5" "97.6" "111.5" "103.4" "94.6" "98.1" "" "" "" "" "" "" "" "" "" "" "86.4" "70.0" "80.2" "52.1" "93.0" "83.3" "94.6" "74.9" "63.8" "98.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7544877575899964257" "False" "High" "IsMasterProtein" "Q96C57" "Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2" "0.000" "False" "17.609" "13" "3" "5" "3" "262" "28.2" "9.42" "15.52" "3" "cell-cell signaling;signal transduction;other biological processes" "nucleus" "" "" "64897" "ENSG00000157895" "CUSTOS" "Q53HF0; Q96C57; Q9H9Z7" "" "" "0" "0" "0.860" "1.072" "1.226" "1.082" "1.620" "1.052" "1.176" "1.290" "0.313" "25.9" "22.3" "27.8" "31.8" "28.1" "42.0" "27.3" "30.5" "33.5" "8.1" "" "" "" "" "" "" "" "" "" "" "23.4" "17.2" "21.5" "21.4" "23.4" "35.9" "23.2" "22.1" "22.6" "8.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643865994575879356" "False" "High" "IsMasterProtein" "Q7Z6M4" "Transcription termination factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF4 PE=1 SV=3" "0.000" "False" "17.556" "6" "2" "4" "2" "381" "43.9" "4.82" "15.92" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf02536" "130916" "ENSG00000122085" "MTERF4" "A8K6K0; hsa:130916; Q7Z6M4; Q9P0E0" "rRNA modification in the mitochondrion" "CCL18 signaling pathway; 2q37 copy number variation syndrome" "3" "0" "1.206" "1.035" "1.122" "1.174" "1.078" "1.154" "1.075" "1.184" "1.157" "165.4" "199.4" "171.2" "185.6" "194.2" "178.2" "190.9" "177.8" "195.8" "191.4" "" "" "" "" "" "" "" "" "" "" "149.3" "153.8" "132.4" "125.0" "162.0" "152.1" "161.9" "128.7" "132.0" "191.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5461850800476976864" "False" "High" "IsMasterProtein" "Q9UBB5" "Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1" "0.000" "False" "17.538" "16" "4" "4" "4" "411" "43.2" "10.04" "13.21" "4" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "8932" "ENSG00000134046" "MBD2" "hsa:8932; O95242; Q9UBB5; Q9UIS8" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening" "Effect of progerin on genes involved in progeria" "3" "0" "1.021" "1.333" "1.118" "1.092" "1.514" "0.967" "0.999" "1.470" "2.577" "128.4" "131.1" "171.2" "143.6" "140.2" "194.4" "124.2" "128.3" "188.8" "331.0" "" "" "" "" "" "" "" "" "" "" "115.9" "101.1" "132.4" "96.7" "117.0" "165.9" "105.4" "92.9" "127.4" "331.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6182186368676627238" "False" "High" "IsMasterProtein" "Q13405" "Large ribosomal subunit protein mL49 OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" "0.000" "False" "17.525" "16" "2" "7" "2" "166" "19.2" "9.45" "21.46" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05046" "740" "ENSG00000149792" "MRPL49" "B2R4G6; hsa:740; Q13405" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.070" "0.850" "1.292" "1.210" "1.068" "0.860" "0.907" "1.004" "1.079" "65.7" "70.3" "55.8" "84.8" "79.5" "70.2" "56.5" "59.6" "66.0" "70.9" "" "" "" "" "" "" "" "" "" "" "59.3" "54.2" "43.2" "57.1" "66.3" "59.9" "47.9" "43.1" "44.5" "70.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7240944493038279722" "False" "High" "IsMasterProtein" "Q9Y676" "Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1" "0.000" "False" "17.510" "24" "5" "6" "5" "258" "29.4" "9.38" "18.79" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01084" "28973" "ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813" "MRPS18B" "A6NDQ0; hsa:28973; Q659G4; Q9BS27; Q9Y676" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.981" "0.817" "0.968" "0.983" "0.849" "0.879" "0.884" "0.774" "1.097" "172.2" "168.9" "140.6" "166.8" "169.2" "146.2" "151.5" "152.3" "133.3" "189.0" "" "" "" "" "" "" "" "" "" "" "155.5" "130.3" "108.8" "112.3" "141.2" "124.8" "128.5" "110.2" "89.9" "189.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3305508852960409357" "False" "High" "IsMasterProtein" "Cont_Q7SIH1" "Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2" "0.000" "True" "17.492" "3" "5" "5" "5" "1510" "167.5" "6.02" "14.72" "5" "" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791" "513856" "" "A2M" "A8E647; bta:513856; Q7SIH1" "" "" "0" "0" "0.966" "0.982" "1.062" "0.967" "1.331" "0.972" "1.029" "1.333" "0.846" "221.7" "214.1" "217.8" "235.3" "214.3" "295.2" "215.4" "228.1" "295.6" "187.5" "" "" "" "" "" "" "" "" "" "" "200.1" "165.1" "168.4" "158.5" "178.8" "251.9" "182.7" "165.1" "199.4" "187.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403678717829717744" "False" "High" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2B PE=1 SV=1" "0.000" "False" "17.486" "37" "3" "9" "3" "86" "10.1" "6.52" "29.39" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "" "1" "0" "0.974" "0.861" "1.030" "0.971" "0.964" "1.003" "0.961" "0.789" "1.002" "215.7" "210.1" "185.8" "222.3" "209.5" "207.9" "216.4" "207.2" "170.2" "216.2" "" "" "" "" "" "" "" "" "" "" "194.7" "162.1" "143.7" "149.7" "174.7" "177.5" "183.6" "150.0" "114.8" "216.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3384207672428186398" "False" "High" "IsMasterProtein" "Q8N335" "Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1" "0.000" "False" "17.484" "17" "6" "6" "6" "351" "38.4" "7.02" "17.93" "6" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "23171" "ENSG00000152642" "GPD1L" "A8K9U3; hsa:23171; Q14702; Q8N335; Q9BRM5" "Synthesis of PA" "Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "0" "1.152" "0.789" "0.988" "1.023" "0.908" "0.943" "1.002" "0.772" "0.826" "141.9" "163.5" "112.0" "140.2" "145.3" "128.9" "133.9" "142.2" "109.6" "117.3" "" "" "" "" "" "" "" "" "" "" "128.1" "126.1" "86.6" "94.4" "121.2" "110.0" "113.6" "102.9" "73.9" "117.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468856902780976606" "False" "High" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "0.000" "False" "17.482" "13" "5" "7" "5" "412" "45.7" "6.48" "18.20" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "" "1" "0" "0.908" "0.968" "1.068" "0.941" "0.881" "0.988" "0.956" "0.827" "1.456" "422.1" "383.1" "408.7" "450.7" "397.3" "372.0" "416.9" "403.6" "348.9" "614.8" "" "" "" "" "" "" "" "" "" "" "381.0" "295.5" "316.1" "303.5" "331.4" "317.5" "353.6" "292.1" "235.3" "614.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4890762250346228692" "False" "High" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "0.000" "False" "17.470" "16" "4" "4" "4" "354" "39.1" "6.44" "14.25" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "27" "0" "1.567" "1.143" "1.029" "1.050" "1.565" "1.432" "1.039" "1.342" "0.885" "20.3" "31.8" "23.2" "20.9" "21.3" "31.8" "29.0" "21.1" "27.2" "18.0" "" "" "" "" "" "" "" "" "" "" "18.3" "24.5" "17.9" "14.1" "17.8" "27.1" "24.6" "15.3" "18.4" "18.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2127950675318566661" "False" "High" "IsMasterProtein" "Q9UJA5" "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1" "0.000" "False" "17.469" "7" "5" "5" "5" "497" "55.8" "7.55" "17.54" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf04189" "51605" "ENSG00000089195" "TRMT6" "B4DUV6; hsa:51605; Q76P92; Q9BQV5; Q9UJA5; Q9ULR7; Q9Y2Z8" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.933" "0.980" "1.270" "1.107" "1.127" "1.123" "0.969" "1.162" "0.806" "149.4" "139.5" "146.5" "189.8" "165.4" "168.4" "167.9" "144.9" "173.7" "120.5" "" "" "" "" "" "" "" "" "" "" "134.9" "107.6" "113.3" "127.8" "138.0" "143.7" "142.4" "104.8" "117.1" "120.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951709946097313123" "False" "High" "IsMasterProtein" "P78362" "SRSF protein kinase 2 OS=Homo sapiens OX=9606 GN=SRPK2 PE=1 SV=3" "0.000" "False" "17.464" "9" "6" "7" "5" "688" "77.5" "4.97" "19.82" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6733" "ENSG00000135250" "SRPK2" "A8MVX2; hsa:6733; O75220; O75221; P78362; Q6NUL0; Q6V1X2; Q8IYQ3" "Maturation of nucleoprotein" "mRNA processing" "2" "0" "1.000" "0.916" "0.986" "1.037" "0.867" "0.986" "0.942" "0.948" "0.829" "393.3" "393.1" "360.2" "387.7" "408.0" "340.9" "388.0" "370.6" "373.0" "326.1" "" "" "" "" "" "" "" "" "" "" "355.0" "303.2" "278.6" "261.1" "340.3" "291.0" "329.1" "268.2" "251.6" "326.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7011076575076357199" "False" "High" "IsMasterProtein" "O00442" "RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1" "0.000" "False" "17.449" "12" "4" "4" "4" "366" "39.3" "7.85" "13.71" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01137, Pf05189" "8634" "ENSG00000137996" "RTCA" "hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99" "" "" "0" "0" "1.067" "0.994" "1.126" "1.071" "0.876" "1.069" "1.020" "1.057" "0.888" "511.4" "545.6" "508.1" "575.7" "547.8" "448.0" "546.6" "521.7" "540.5" "454.1" "" "" "" "" "" "" "" "" "" "" "461.6" "420.9" "393.0" "387.7" "456.9" "382.4" "463.6" "377.5" "364.6" "454.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4405181458594490981" "False" "High" "IsMasterProtein" "Q9NYL2" "Mitogen-activated protein kinase kinase kinase 20 OS=Homo sapiens OX=9606 GN=MAP3K20 PE=1 SV=3" "0.000" "False" "17.448" "4" "3" "3" "3" "800" "91.1" "7.87" "9.39" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00536, Pf07714" "51776" "ENSG00000091436" "MAP3K20" "B3KPG2; hsa:51776; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; Q9NYL2" "" "MAPK signaling pathway" "1" "0" "1.004" "1.060" "0.834" "1.162" "0.986" "1.080" "0.804" "0.998" "1.098" "40.4" "40.6" "42.8" "33.7" "46.9" "39.9" "43.6" "32.5" "40.3" "44.3" "" "" "" "" "" "" "" "" "" "" "36.5" "31.3" "33.1" "22.7" "39.2" "34.0" "37.0" "23.5" "27.2" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8979611846707191829" "False" "High" "IsMasterProtein" "O76080" "AN1-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=ZFAND5 PE=1 SV=1" "0.000" "False" "17.447" "25" "3" "3" "3" "213" "23.1" "8.51" "15.48" "3" "developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "7763" "ENSG00000107372" "ZFAND5" "A8K484; hsa:7763; O76080" "" "" "0" "0" "0.962" "0.910" "1.090" "0.959" "0.910" "0.987" "1.015" "0.882" "0.706" "175.8" "169.1" "160.0" "191.6" "168.6" "159.9" "173.5" "178.4" "155.0" "124.2" "" "" "" "" "" "" "" "" "" "" "158.7" "130.5" "123.7" "129.0" "140.7" "136.5" "147.2" "129.1" "104.5" "124.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700006474042265009" "False" "High" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "0.000" "False" "17.417" "7" "5" "8" "1" "585" "63.8" "9.04" "27.98" "5" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "1" "0.947" "1.059" "1.031" "0.950" "0.971" "0.975" "0.986" "1.025" "1.184" "221.5" "209.7" "234.5" "228.2" "210.3" "215.2" "215.9" "218.4" "227.0" "262.3" "" "" "" "" "" "" "" "" "" "" "199.9" "161.7" "181.4" "153.7" "175.4" "183.6" "183.1" "158.1" "153.1" "262.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4014732936272449079" "False" "High" "IsMasterProtein" "Q53EL6" "Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2" "0.000" "False" "17.416" "7" "3" "5" "3" "469" "51.7" "5.21" "17.55" "3" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02847" "27250" "ENSG00000150593" "PDCD4" "B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Translation inhibitors in chronically activated PDGFRA cells; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "4" "0" "0.994" "0.682" "0.994" "0.964" "0.825" "0.982" "0.861" "0.859" "1.986" "241.0" "239.5" "164.3" "239.6" "232.2" "198.9" "236.6" "207.5" "207.1" "478.7" "" "" "" "" "" "" "" "" "" "" "217.5" "184.8" "127.1" "161.3" "193.7" "169.8" "200.7" "150.2" "139.7" "478.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4088167174397650062" "False" "High" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "0.000" "False" "17.413" "12" "5" "11" "5" "369" "39.1" "6.30" "30.31" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "0.982" "0.943" "0.969" "1.013" "0.914" "0.979" "0.948" "0.972" "0.742" "654.0" "642.5" "616.6" "634.1" "662.4" "597.9" "640.5" "620.3" "635.4" "485.5" "" "" "" "" "" "" "" "" "" "" "590.4" "495.6" "476.9" "427.0" "552.5" "510.3" "543.3" "448.9" "428.6" "485.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1708640290626267049" "False" "High" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "0.000" "False" "17.385" "20" "3" "8" "3" "136" "14.6" "10.04" "29.08" "3" "other biological processes" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "" "2" "0" "0.971" "1.009" "0.925" "0.994" "0.976" "0.964" "0.962" "0.889" "0.728" "1214.1" "1179.1" "1224.7" "1122.7" "1206.2" "1184.9" "1170.4" "1167.7" "1079.7" "883.7" "" "" "" "" "" "" "" "" "" "" "1095.9" "909.5" "947.2" "756.0" "1006.2" "1011.3" "992.9" "845.1" "728.2" "883.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5515893546974733261" "False" "High" "IsMasterProtein" "E9PRG8" "Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11orf98 PE=1 SV=2" "0.000" "False" "17.383" "23" "3" "4" "3" "123" "14.2" "11.53" "14.33" "3" "" "" "" "Pf17719" "102288414" "ENSG00000278615" "C11orf98" "A0A0B4J220; E9PRG8; hsa:102288414" "" "" "0" "0" "1.010" "1.102" "1.060" "1.074" "0.983" "1.025" "1.085" "1.011" "0.626" "252.2" "254.8" "278.0" "267.3" "270.9" "247.8" "258.6" "273.7" "255.0" "157.9" "" "" "" "" "" "" "" "" "" "" "227.6" "196.5" "215.0" "180.0" "226.0" "211.5" "219.3" "198.1" "172.0" "157.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194436757358923865" "False" "High" "IsMasterProtein" "Q5W0V3" "FHF complex subunit HOOK interacting protein 2A OS=Homo sapiens OX=9606 GN=FHIP2A PE=1 SV=1" "0.000" "False" "17.365" "4" "3" "4" "3" "765" "86.5" "5.29" "15.54" "3" "" "" "" "Pf10257, Pf19311, Pf19314" "57700" "ENSG00000151553" "FHIP2A" "Q5H9P7; Q5W0V2; Q5W0V3; Q8IY76; Q9HCH2" "" "" "0" "0" "1.125" "0.842" "1.064" "1.036" "0.801" "1.127" "1.029" "0.841" "1.120" "292.7" "329.4" "246.5" "311.6" "303.3" "234.4" "330.1" "301.3" "246.1" "327.8" "" "" "" "" "" "" "" "" "" "" "264.3" "254.1" "190.6" "209.8" "253.0" "200.0" "280.0" "218.0" "166.0" "327.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1354238916064112101" "False" "High" "IsMasterProtein" "Q5T6V5" "Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Homo sapiens OX=9606 GN=QNG1 PE=1 SV=1" "0.000" "False" "17.362" "16" "6" "9" "6" "341" "39.0" "5.88" "20.72" "6" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf10343" "84267" "ENSG00000165118" "QNG1" "B2RPI6; hsa:84267; Q5T6V5; Q8N2B1; Q9BT18" "" "" "0" "0" "0.892" "1.036" "0.984" "0.860" "1.043" "0.715" "0.678" "1.227" "1.620" "158.6" "141.5" "164.3" "156.0" "136.4" "165.4" "113.5" "107.6" "194.5" "257.0" "" "" "" "" "" "" "" "" "" "" "143.2" "109.2" "127.1" "105.1" "113.8" "141.1" "96.3" "77.8" "131.2" "257.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5919366994915360532" "False" "High" "IsMasterProtein" "Q8NI60" "Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1" "0.000" "False" "17.361" "7" "4" "4" "4" "647" "71.9" "6.99" "10.71" "4" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf03109" "56997" "ENSG00000163050" "COQ8A" "hsa:56997; Q5T7A5; Q63HK0; Q8NCJ6; Q8NI60; Q9HBQ1; Q9NQ67" "" "" "0" "0" "1.142" "0.976" "1.074" "1.209" "0.872" "1.064" "1.314" "1.086" "1.087" "185.9" "212.4" "181.5" "199.7" "224.7" "162.2" "197.8" "244.4" "201.9" "202.1" "" "" "" "" "" "" "" "" "" "" "167.8" "163.8" "140.4" "134.5" "187.5" "138.4" "167.8" "176.8" "136.2" "202.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6713486079386730204" "False" "High" "IsMasterProtein" "P50454" "Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2" "0.000" "False" "17.353" "8" "3" "4" "3" "418" "46.4" "8.69" "12.83" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "non-structural extracellular;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "871" "ENSG00000149257" "SERPINH1" "B3KVJ3; hsa:871; P29043; P50454; Q5XPB4; Q6NSJ6; Q8IY96; Q9NP88" "Collagen biosynthesis and modifying enzymes" "Endochondral ossification; Type I collagen synthesis in the context of osteogenesis imperfecta; Endochondral ossification with skeletal dysplasias; 15q13.3 copy number variation syndrome; 15q11q13 copy number variation" "6" "0" "1.006" "1.045" "0.986" "0.988" "1.009" "0.910" "1.013" "1.129" "0.774" "365.8" "367.9" "382.2" "360.5" "361.2" "369.2" "332.8" "370.5" "412.8" "283.1" "" "" "" "" "" "" "" "" "" "" "330.2" "283.8" "295.6" "242.8" "301.3" "315.1" "282.3" "268.1" "278.4" "283.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220187434067665020" "False" "High" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "0.000" "False" "17.353" "6" "4" "5" "4" "736" "82.8" "7.31" "16.10" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "0.967" "1.328" "0.966" "0.837" "1.071" "0.836" "1.000" "1.262" "1.222" "186.6" "180.4" "247.8" "180.3" "156.3" "200.0" "155.9" "186.5" "235.4" "228.1" "" "" "" "" "" "" "" "" "" "" "168.5" "139.1" "191.7" "121.4" "130.4" "170.7" "132.3" "135.0" "158.8" "228.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8332128719972757989" "False" "High" "IsMasterProtein" "Q8IY67" "Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1" "0.000" "False" "17.351" "5" "2" "3" "2" "606" "63.8" "8.48" "11.38" "2" "" "nucleus;other cell component" "" "Pf00076" "125950" "" "RAVER1" "A6NMU4; hsa:125950; Q8IY60; Q8IY67; Q8TF24" "" "" "0" "0" "1.112" "1.412" "1.135" "1.077" "1.279" "1.037" "0.675" "1.508" "7.163" "137.8" "153.3" "194.6" "156.4" "148.4" "176.3" "142.9" "93.0" "207.9" "987.4" "" "" "" "" "" "" "" "" "" "" "124.4" "118.2" "150.5" "105.3" "123.8" "150.5" "121.2" "67.3" "140.2" "987.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163980209620091115" "False" "High" "IsMasterProtein" "O43598" "5-hydroxymethyl-dUMP N-hydrolase OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "0.000" "False" "17.331" "24" "3" "6" "3" "174" "19.1" "5.05" "20.63" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "Purine catabolism" "" "1" "0" "0.981" "1.059" "1.176" "1.331" "1.168" "1.153" "1.055" "1.030" "0.696" "180.1" "176.6" "190.8" "211.7" "239.6" "210.4" "207.7" "190.1" "185.5" "125.3" "" "" "" "" "" "" "" "" "" "" "162.5" "136.2" "147.5" "142.6" "199.9" "179.5" "176.1" "137.5" "125.1" "125.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8843415988459270294" "False" "High" "IsMasterProtein" "Q7Z2W9" "Large ribosomal subunit protein bL21m OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" "0.000" "False" "17.274" "25" "4" "7" "4" "205" "22.8" "9.89" "23.25" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00829" "219927" "ENSG00000197345" "MRPL21" "A6NKU0; C9JPR2; hsa:219927; Q7Z2W9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.022" "0.872" "1.028" "1.121" "0.960" "1.063" "1.066" "0.884" "0.988" "232.0" "237.2" "202.3" "238.4" "260.1" "222.7" "246.5" "247.3" "205.2" "229.3" "" "" "" "" "" "" "" "" "" "" "209.5" "183.0" "156.5" "160.6" "217.0" "190.1" "209.1" "179.0" "138.4" "229.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4723246947420564514" "False" "High" "IsMasterProtein" "O94915" "Protein furry homolog-like OS=Homo sapiens OX=9606 GN=FRYL PE=1 SV=2" "0.000" "False" "17.269" "2" "7" "7" "7" "3013" "339.4" "5.58" "17.12" "7" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf14222, Pf14225, Pf14228, Pf19421" "285527" "ENSG00000075539" "FRYL" "hsa:285527; O94915; O95640; Q8WTZ5; Q9NT40" "" "" "0" "0" "1.112" "0.956" "1.050" "1.160" "0.935" "1.110" "1.110" "0.905" "0.900" "316.0" "351.4" "302.0" "331.9" "366.5" "295.4" "350.6" "350.7" "286.1" "284.6" "" "" "" "" "" "" "" "" "" "" "285.2" "271.1" "233.6" "223.5" "305.7" "252.1" "297.4" "253.8" "193.0" "284.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026735558710273601" "False" "High" "IsMasterProtein" "P36507" "Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1" "0.000" "False" "17.250" "15" "6" "7" "4" "400" "44.4" "6.55" "18.61" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5605" "ENSG00000126934" "MAP2K2" "hsa:5605; P36507" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "88" "0" "0.951" "0.743" "1.007" "1.005" "0.726" "0.921" "0.946" "0.791" "0.741" "232.1" "220.7" "172.5" "233.8" "233.2" "168.4" "213.8" "219.5" "183.6" "172.1" "" "" "" "" "" "" "" "" "" "" "209.5" "170.2" "133.4" "157.4" "194.5" "143.8" "181.4" "158.8" "123.8" "172.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575198767162097907" "False" "High" "IsMasterProtein" "Q9BXV9" "EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2" "0.000" "False" "17.240" "53" "3" "5" "3" "100" "10.9" "4.27" "16.87" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15387" "84520" "ENSG00000170270; ENSG00000275619" "GON7" "Q0D2N1; Q0P6C4; Q3B7W5; Q9BXV9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1310996743308863221" "False" "High" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "0.000" "False" "17.233" "20" "6" "6" "6" "250" "28.7" "8.75" "13.82" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; Q96FX0; Q9NV53; Q9Y3A5" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "1.077" "0.853" "1.023" "0.986" "1.105" "1.050" "0.903" "1.039" "1.443" "141.2" "152.1" "120.5" "144.5" "139.2" "156.0" "148.3" "127.5" "146.8" "203.8" "" "" "" "" "" "" "" "" "" "" "127.5" "117.3" "93.2" "97.3" "116.1" "133.1" "125.8" "92.3" "99.0" "203.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295082137940750650" "False" "High" "IsMasterProtein" "O43633" "Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1" "0.000" "False" "17.230" "8" "1" "3" "1" "222" "25.1" "5.97" "13.33" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "27243" "ENSG00000130724" "CHMP2A" "B2R4W6; hsa:27243; O43633; Q3ZTT0" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "10" "0" "1.326" "1.435" "1.340" "1.513" "1.041" "1.104" "1.402" "1.251" "0.923" "20.6" "27.3" "29.6" "27.6" "31.2" "21.4" "22.8" "28.9" "25.8" "19.0" "" "" "" "" "" "" "" "" "" "" "18.6" "21.1" "22.9" "18.6" "26.0" "18.3" "19.3" "20.9" "17.4" "19.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7480340352347879805" "False" "High" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "0.000" "False" "17.220" "7" "5" "6" "5" "802" "92.2" "8.18" "15.51" "5" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "mRNA Splicing - Major Pathway" "" "1" "0" "1.037" "2.347" "1.095" "1.084" "2.136" "1.046" "0.771" "2.285" "3.651" "181.0" "187.8" "424.9" "198.3" "196.2" "386.6" "189.3" "139.6" "413.6" "660.9" "" "" "" "" "" "" "" "" "" "" "163.4" "144.9" "328.6" "133.5" "163.7" "330.0" "160.6" "101.0" "279.0" "660.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-390863097898701106" "False" "High" "IsMasterProtein" "Q14657" "EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2" "0.000" "False" "17.214" "16" "2" "9" "2" "143" "14.8" "8.63" "24.16" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09341" "8270" "ENSG00000196976" "LAGE3" "hsa:8270; Q14657; Q5HY39; Q8IZ78" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.214" "1.370" "1.229" "1.234" "1.293" "1.212" "1.227" "1.503" "1.517" "108.6" "132.0" "148.8" "133.5" "134.1" "140.5" "131.7" "133.3" "163.3" "164.8" "" "" "" "" "" "" "" "" "" "" "98.1" "101.8" "115.1" "89.9" "111.9" "119.9" "111.7" "96.4" "110.2" "164.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158883592383283846" "False" "High" "IsMasterProtein" "P60983" "Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2" "0.000" "False" "17.157" "14" "2" "4" "1" "142" "16.7" "5.29" "15.76" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "2764" "ENSG00000197045" "GMFB" "B2R499; hsa:2764; P17774; P60983; Q9BS35" "" "" "0" "0" "1.028" "1.022" "1.266" "1.127" "1.309" "1.127" "1.094" "1.225" "0.662" "56.7" "58.3" "58.0" "71.8" "63.9" "74.3" "63.9" "62.1" "69.5" "37.5" "" "" "" "" "" "" "" "" "" "" "51.2" "45.0" "44.8" "48.4" "53.3" "63.4" "54.2" "44.9" "46.9" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "208143562843118343" "False" "High" "IsMasterProtein" "Q8NFH5" "Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1" "0.000" "False" "17.157" "16" "4" "5" "4" "326" "34.8" "9.09" "15.17" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05172" "129401" "ENSG00000163002" "NUP35" "B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; HCMV Early Events; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "" "29" "0" "1.062" "0.828" "0.961" "1.111" "0.853" "1.003" "1.075" "0.852" "1.161" "246.6" "262.0" "204.3" "237.0" "273.9" "210.3" "247.5" "265.2" "210.2" "286.3" "" "" "" "" "" "" "" "" "" "" "222.6" "202.1" "158.0" "159.6" "228.5" "179.5" "209.9" "191.9" "141.8" "286.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801504579459921117" "False" "High" "IsMasterProtein" "Q8IXQ3" "Uncharacterized protein C9orf40 OS=Homo sapiens OX=9606 GN=C9orf40 PE=1 SV=1" "0.000" "False" "17.154" "22" "4" "5" "4" "194" "21.1" "5.01" "13.20" "4" "" "" "" "Pf15017" "55071" "ENSG00000135045" "C9orf40" "hsa:55071; Q8IXQ3; Q9NWD3" "" "" "0" "0" "1.005" "0.830" "1.065" "1.015" "0.867" "0.961" "1.051" "0.898" "0.783" "366.8" "368.5" "304.5" "390.8" "372.1" "317.9" "352.4" "385.4" "329.4" "287.4" "" "" "" "" "" "" "" "" "" "" "331.1" "284.3" "235.5" "263.2" "310.4" "271.3" "298.9" "278.9" "222.2" "287.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2601253202356678168" "False" "High" "IsMasterProtein" "P31937" "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2" "0.000" "False" "17.143" "9" "2" "3" "2" "336" "35.3" "8.13" "11.81" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf03446, Pf14833" "11112" "ENSG00000106049" "HIBADH" "hsa:11112; P31937; Q546Z2; Q9UDN3" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "1.062" "1.060" "0.990" "1.149" "0.976" "0.849" "1.002" "1.009" "0.612" "57.2" "60.8" "60.6" "56.6" "65.7" "55.9" "48.6" "57.3" "57.7" "35.0" "" "" "" "" "" "" "" "" "" "" "51.6" "46.9" "46.9" "38.1" "54.8" "47.7" "41.2" "41.5" "38.9" "35.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4492999109905159377" "False" "High" "IsMasterProtein" "Q15121" "Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2" "0.000" "False" "17.067" "35" "4" "7" "4" "130" "15.0" "5.02" "20.80" "4" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01335" "8682" "ENSG00000162734" "PEA15" "B1AKZ3; hsa:8682; O00511; Q15121" "RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation" "Apoptosis modulation and signaling" "3" "0" "0.965" "0.715" "1.040" "0.949" "0.774" "0.950" "0.957" "0.806" "1.440" "932.8" "899.8" "667.2" "970.0" "884.8" "722.0" "886.0" "892.4" "752.1" "1343.0" "" "" "" "" "" "" "" "" "" "" "842.0" "694.0" "516.1" "653.2" "738.1" "616.2" "751.5" "645.8" "507.3" "1343.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3251544276452061183" "False" "High" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "0.000" "False" "17.066" "9" "5" "10" "5" "475" "53.5" "9.09" "27.34" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "Protein hydroxylation; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates" "7" "0" "1.012" "1.272" "0.927" "0.817" "1.150" "0.888" "1.000" "1.025" "1.157" "255.1" "258.1" "324.4" "236.4" "208.5" "293.3" "226.5" "255.2" "261.4" "295.1" "" "" "" "" "" "" "" "" "" "" "230.2" "199.1" "250.9" "159.2" "173.9" "250.3" "192.1" "184.7" "176.3" "295.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894202004243013211" "False" "High" "IsMasterProtein" "O15530" "3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1" "0.000" "False" "17.063" "6" "3" "6" "3" "556" "63.1" "7.36" "17.45" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf14593" "5170" "ENSG00000140992" "PDPK1" "H0Y4Z0; hsa:5170; O15530; Q59EH6; Q6FI20; Q8IV52; Q9BRD5" "Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway" "46" "0" "1.026" "0.894" "1.103" "1.057" "0.996" "1.231" "1.115" "0.978" "1.518" "92.9" "95.3" "83.0" "102.5" "98.2" "92.5" "114.3" "103.6" "90.8" "141.0" "" "" "" "" "" "" "" "" "" "" "83.8" "73.5" "64.2" "69.0" "81.9" "79.0" "97.0" "74.9" "61.3" "141.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060406091306601688" "False" "High" "IsMasterProtein" "Q8N806" "Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2" "0.000" "False" "17.049" "15" "6" "6" "6" "425" "48.0" "4.81" "15.68" "6" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf02207" "55148" "ENSG00000012963; ENSG00000278787" "UBR7" "Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6" "" "" "0" "0" "0.877" "0.877" "0.967" "0.901" "0.863" "0.884" "0.938" "0.899" "1.150" "477.8" "418.9" "419.2" "461.9" "430.4" "412.1" "422.6" "448.3" "429.4" "549.7" "" "" "" "" "" "" "" "" "" "" "431.3" "323.2" "324.3" "311.1" "359.0" "351.8" "358.5" "324.4" "289.6" "549.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8547587141624532923" "False" "High" "IsMasterProtein" "Q9UKV8" "Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3" "0.000" "False" "17.045" "7" "5" "9" "5" "859" "97.1" "9.19" "17.84" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "27161" "ENSG00000123908" "AGO2" "Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8" "Transcriptional regulation by small RNAs; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; Pre-NOTCH Transcription and Translation; Regulation of RUNX1 Expression and Activity; Small interfering RNA (siRNA) biogenesis; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 Regulates Metabolic Genes; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Nuclear events stimulated by ALK signaling in cancer; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "24" "0" "1.007" "1.315" "1.074" "1.090" "1.318" "0.987" "1.005" "1.448" "1.128" "177.0" "178.3" "232.7" "190.2" "192.9" "233.4" "174.6" "177.9" "256.4" "199.7" "" "" "" "" "" "" "" "" "" "" "159.8" "137.5" "180.0" "128.1" "160.9" "199.2" "148.1" "128.7" "172.9" "199.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4788954663334132438" "False" "High" "IsMasterProtein" "Q9NWX6" "Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2" "0.000" "False" "17.042" "15" "4" "6" "4" "298" "34.8" "8.00" "18.53" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04446, Pf14413" "54974" "ENSG00000113272" "THG1L" "D3DQJ5; hsa:54974; Q53G12; Q7L5R3; Q9H0S2; Q9NWX6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.893" "0.871" "0.901" "0.901" "1.021" "0.847" "0.938" "0.942" "0.700" "169.2" "151.0" "147.4" "152.4" "152.5" "172.7" "143.2" "158.7" "159.3" "118.4" "" "" "" "" "" "" "" "" "" "" "152.7" "116.5" "114.0" "102.7" "127.2" "147.4" "121.5" "114.9" "107.4" "118.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2780012699029809096" "False" "High" "IsMasterProtein" "Q9H9J2" "Large ribosomal subunit protein mL44 OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "0.000" "False" "17.038" "11" "3" "5" "3" "332" "37.5" "8.40" "19.20" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.013" "0.807" "1.087" "1.017" "0.838" "1.000" "0.975" "0.779" "1.049" "377.2" "382.3" "304.6" "410.0" "383.8" "316.1" "377.3" "367.9" "294.0" "395.8" "" "" "" "" "" "" "" "" "" "" "340.5" "294.9" "235.6" "276.1" "320.1" "269.8" "320.1" "266.3" "198.3" "395.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8717511238945883438" "False" "High" "IsMasterProtein" "Q12769" "Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3" "0.000" "False" "17.038" "4" "6" "8" "6" "1436" "162.0" "5.50" "20.33" "6" "other metabolic processes;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf11715" "23279" "ENSG00000030066" "NUP160" "B4DYE8; B4E2J9; hsa:23279; Q08AD3; Q12769; Q7Z5X6; Q96GB3; Q9H660" "SUMOylation of DNA replication proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "35" "0" "0.948" "0.861" "1.087" "1.021" "0.734" "1.064" "1.071" "0.761" "1.033" "324.5" "307.7" "279.3" "352.6" "331.3" "238.1" "345.4" "347.6" "247.0" "335.3" "" "" "" "" "" "" "" "" "" "" "292.9" "237.4" "216.0" "237.5" "276.3" "203.2" "293.0" "251.5" "166.6" "335.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740436620154947735" "False" "High" "IsMasterProtein" "Q9BX68" "Adenosine 5'-monophosphoramidase HINT2 OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1" "0.000" "False" "17.034" "30" "4" "6" "4" "163" "17.2" "9.16" "15.91" "4" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01230" "84681" "ENSG00000137133" "HINT2" "hsa:84681; Q5TCW3; Q9BX68" "RHOD GTPase cycle" "" "1" "0" "1.250" "0.897" "0.863" "1.133" "1.108" "0.918" "1.066" "1.132" "0.689" "22.1" "27.6" "19.8" "19.1" "25.0" "24.5" "20.3" "23.5" "25.0" "15.2" "" "" "" "" "" "" "" "" "" "" "19.9" "21.3" "15.3" "12.8" "20.9" "20.9" "17.2" "17.0" "16.9" "15.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4717651617297181896" "False" "High" "IsMasterProtein" "Q9UIC8" "Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2" "0.000" "False" "17.024" "13" "5" "7" "5" "334" "38.4" "6.04" "18.75" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04072" "51451" "ENSG00000205629" "LCMT1" "A6NL89; A8K770; hsa:51451; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9UIC8; Q9Y378" "Cyclin A/B1/B2 associated events during G2/M transition" "" "1" "0" "0.971" "0.864" "0.991" "0.963" "0.884" "0.985" "0.947" "0.908" "0.905" "807.8" "784.3" "697.8" "800.3" "777.9" "714.2" "795.7" "764.6" "733.4" "730.7" "" "" "" "" "" "" "" "" "" "" "729.1" "605.0" "539.7" "538.9" "648.9" "609.6" "675.0" "553.3" "494.7" "730.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1714630333721311506" "False" "High" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "0.000" "False" "17.022" "12" "5" "5" "5" "386" "43.5" "8.19" "16.03" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Branched-chain amino acid catabolism" "Amino acid metabolism" "2" "0" "1.027" "0.949" "0.875" "1.020" "0.899" "1.022" "0.923" "0.898" "1.167" "766.7" "787.7" "727.7" "670.7" "782.3" "689.2" "783.8" "708.0" "688.2" "894.8" "" "" "" "" "" "" "" "" "" "" "692.1" "607.6" "562.8" "451.7" "652.6" "588.3" "664.9" "512.4" "464.2" "894.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4404494894943398685" "False" "High" "IsMasterProtein" "Q6P5R6" "Ribosomal protein eL22-like OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2" "0.000" "False" "17.008" "28" "3" "6" "3" "122" "14.6" "9.38" "15.44" "3" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01776" "200916" "ENSG00000163584" "RPL22L1" "hsa:200916; Q32Q77; Q6P5R6" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "13" "0" "0.995" "0.992" "0.947" "1.009" "0.960" "1.053" "1.081" "1.042" "0.971" "260.5" "259.3" "258.4" "246.7" "263.0" "250.1" "274.2" "281.7" "271.4" "253.1" "" "" "" "" "" "" "" "" "" "" "235.2" "200.0" "199.9" "166.1" "219.4" "213.5" "232.6" "203.8" "183.1" "253.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696215040566855502" "False" "High" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "0.000" "False" "17.007" "13" "4" "7" "4" "243" "27.9" "4.20" "19.18" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773, Pf16543" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "Protein hydroxylation" "" "1" "0" "0.987" "0.801" "0.978" "0.880" "0.869" "1.026" "0.860" "0.774" "0.779" "59.7" "58.9" "47.8" "58.4" "52.5" "51.9" "61.3" "51.4" "46.3" "46.5" "" "" "" "" "" "" "" "" "" "" "53.9" "45.5" "37.0" "39.4" "43.8" "44.3" "52.0" "37.2" "31.2" "46.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-788718536083084523" "False" "High" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "0.000" "False" "16.976" "12" "3" "3" "3" "285" "33.0" "5.17" "11.76" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "5" "0" "1.053" "1.039" "0.993" "0.947" "1.097" "0.881" "0.997" "1.133" "1.712" "253.3" "266.6" "263.2" "251.4" "239.8" "277.7" "223.1" "252.6" "286.9" "433.7" "" "" "" "" "" "" "" "" "" "" "228.6" "205.6" "203.6" "169.3" "200.0" "237.0" "189.2" "182.8" "193.5" "433.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218333417811039911" "False" "High" "IsMasterProtein" "Q9H299" "SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1" "0.000" "False" "16.974" "35" "3" "8" "3" "93" "10.4" "4.93" "19.58" "3" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04908" "83442" "ENSG00000142669" "SH3BGRL3" "hsa:83442; Q5T122; Q9H299" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.119" "1.239" "1.013" "1.004" "1.171" "1.056" "1.152" "1.287" "0.817" "104.4" "116.8" "129.3" "105.7" "104.8" "122.2" "110.2" "120.2" "134.3" "85.2" "" "" "" "" "" "" "" "" "" "" "94.2" "90.1" "100.0" "71.2" "87.4" "104.3" "93.5" "87.0" "90.6" "85.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370481134034691073" "False" "High" "IsMasterProtein" "P22307" "Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2" "0.000" "False" "16.973" "5" "3" "6" "3" "547" "59.0" "6.89" "22.05" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00108, Pf02036, Pf02803" "6342" "ENSG00000116171" "SCP2" "A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1; hsa:6342; P22307; Q15432; Q16622; Q5VVZ1; Q6NXF4; Q99430" "TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Mitochondrial fatty acid oxidation disorders; DNA damage response (only ATM dependent)" "10" "0" "1.067" "1.050" "0.985" "0.962" "0.951" "1.009" "1.052" "1.027" "0.733" "443.9" "473.6" "466.2" "437.3" "426.9" "422.1" "448.1" "466.8" "455.8" "325.2" "" "" "" "" "" "" "" "" "" "" "400.7" "365.3" "360.6" "294.5" "356.1" "360.2" "380.1" "337.8" "307.4" "325.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8296927392794764826" "False" "High" "IsMasterProtein" "Q9BZL4" "Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C PE=1 SV=1" "0.000" "False" "16.966" "7" "5" "5" "5" "782" "84.8" "5.57" "15.45" "5" "signal transduction" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf12796, Pf15898" "54776" "ENSG00000125503" "PPP1R12C" "B4DME2; hsa:54776; Q59FK8; Q6ZPD1; Q7L8F7; Q96HW1; Q9BZL4; Q9H5H5; Q9NT00" "" "Focal adhesion" "1" "0" "1.159" "1.156" "1.231" "1.144" "1.279" "1.153" "1.176" "1.511" "1.954" "301.0" "348.7" "348.0" "370.6" "344.3" "384.9" "347.1" "354.1" "454.7" "588.2" "" "" "" "" "" "" "" "" "" "" "271.7" "269.0" "269.2" "249.5" "287.2" "328.5" "294.4" "256.2" "306.7" "588.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1992212741193317441" "False" "High" "IsMasterProtein" "Q13247" "Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2" "0.000" "False" "16.961" "17" "7" "8" "3" "344" "39.6" "11.43" "22.53" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6431" "ENSG00000124193" "SRSF6" "B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7" "RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "mRNA processing" "7" "2" "0.972" "0.914" "0.922" "1.064" "0.946" "0.947" "0.943" "0.914" "1.014" "525.2" "510.3" "479.8" "484.0" "559.0" "496.8" "497.4" "495.1" "479.8" "532.5" "" "" "" "" "" "" "" "" "" "" "474.1" "393.6" "371.1" "325.9" "466.3" "424.0" "421.9" "358.3" "323.6" "532.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2608297445267441955" "False" "High" "IsMasterProtein" "Q96QR8" "Transcriptional regulator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "0.000" "False" "16.930" "9" "2" "3" "2" "312" "33.2" "5.43" "11.48" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "0" "1.106" "1.042" "0.935" "1.150" "1.140" "1.152" "1.049" "0.875" "0.739" "114.4" "126.6" "119.2" "107.0" "131.7" "130.5" "131.8" "120.0" "100.2" "84.5" "" "" "" "" "" "" "" "" "" "" "103.3" "97.6" "92.2" "72.1" "109.8" "111.4" "111.8" "86.8" "67.6" "84.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848338417616042821" "False" "High" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "0.000" "False" "16.928" "17" "4" "7" "4" "261" "28.0" "8.05" "18.06" "4" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "" "2" "0" "0.993" "0.914" "1.021" "1.014" "0.922" "0.975" "0.972" "0.931" "0.708" "659.9" "655.2" "602.8" "674.0" "668.9" "608.6" "643.5" "641.5" "614.6" "467.5" "" "" "" "" "" "" "" "" "" "" "595.7" "505.4" "466.2" "453.9" "558.0" "519.4" "545.9" "464.3" "414.6" "467.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2326963864063357056" "False" "High" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "0.000" "False" "16.922" "8" "6" "6" "6" "739" "83.3" "6.70" "12.72" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "4p16.3 copy number variation" "3" "0" "1.004" "1.301" "0.992" "1.088" "1.455" "1.013" "1.071" "1.279" "0.880" "87.9" "88.3" "114.4" "87.2" "95.6" "127.9" "89.0" "94.1" "112.4" "77.4" "" "" "" "" "" "" "" "" "" "" "79.4" "68.1" "88.5" "58.7" "79.8" "109.2" "75.5" "68.1" "75.8" "77.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7145479494712382587" "False" "High" "IsMasterProtein" "P80217" "Interferon-induced 35 kDa protein OS=Homo sapiens OX=9606 GN=IFI35 PE=1 SV=5" "0.000" "False" "16.915" "15" "5" "7" "5" "286" "31.5" "6.09" "21.69" "5" "stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07292, Pf07334" "3430" "ENSG00000068079" "IFI35" "C9JGX1; hsa:3430; P80217; Q92984; Q99537; Q9BV98" "Interferon alpha/beta signaling" "Immune response to tuberculosis" "2" "0" "1.068" "0.988" "1.065" "1.013" "1.065" "1.050" "0.997" "0.991" "0.636" "375.6" "401.2" "371.2" "400.0" "380.5" "399.9" "394.3" "374.5" "372.1" "239.0" "" "" "" "" "" "" "" "" "" "" "339.0" "309.5" "287.1" "269.4" "317.4" "341.3" "334.5" "271.0" "251.0" "239.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5623462440984321357" "False" "High" "IsMasterProtein" "Q96CW5" "Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2" "0.000" "False" "16.913" "4" "3" "3" "3" "907" "103.5" "8.12" "11.26" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04130, Pf17681" "10426" "ENSG00000126216" "TUBGCP3" "hsa:10426; O43631; O60852; O60853; Q5T8L2; Q7Z4K1; Q96CW5; Q96I79" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "0.961" "0.828" "0.992" "0.808" "0.940" "1.040" "0.923" "0.757" "1.336" "84.6" "81.3" "70.0" "83.9" "68.4" "79.5" "87.9" "78.1" "64.0" "113.0" "" "" "" "" "" "" "" "" "" "" "76.4" "62.7" "54.2" "56.5" "57.0" "67.8" "74.6" "56.5" "43.2" "113.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982176321518383" "False" "High" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "0.000" "False" "16.886" "18" "3" "4" "3" "193" "21.7" "5.39" "11.11" "3" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "Golgi Associated Vesicle Biogenesis" "" "1" "0" "1.031" "0.785" "0.859" "0.971" "0.778" "1.026" "1.037" "0.809" "1.061" "238.4" "245.9" "187.2" "204.8" "231.4" "185.5" "244.7" "247.3" "192.9" "253.0" "" "" "" "" "" "" "" "" "" "" "215.2" "189.7" "144.8" "137.9" "193.0" "158.4" "207.6" "178.9" "130.1" "253.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948435004993003441" "False" "High" "IsMasterProtein" "P52594" "Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2" "0.000" "False" "16.861" "11" "7" "9" "7" "562" "58.2" "8.63" "24.10" "7" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01412" "3267" "ENSG00000173744" "AGFG1" "B3KUL1; E9PHX7; hsa:3267; P52594; Q15277; Q4VAS0; Q4VAS1; Q4VAS3; Q53QT8; Q53R11" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "0.912" "0.958" "1.033" "0.935" "1.005" "0.945" "0.983" "1.110" "0.858" "161.0" "146.9" "154.2" "166.3" "150.5" "161.8" "152.0" "158.2" "178.6" "138.1" "" "" "" "" "" "" "" "" "" "" "145.3" "113.3" "119.3" "112.0" "125.6" "138.1" "129.0" "114.5" "120.5" "138.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720248987179001386" "False" "High" "IsMasterProtein" "O60313" "Dynamin-like GTPase OPA1, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "0.000" "False" "16.852" "4" "4" "5" "4" "960" "111.6" "7.87" "16.71" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Mitochondrial protein degradation; Regulation of Apoptosis" "Orexin receptor pathway" "3" "0" "1.005" "0.981" "0.988" "1.005" "0.888" "0.996" "0.930" "0.988" "0.850" "374.8" "376.8" "367.5" "370.3" "376.5" "332.7" "373.4" "348.6" "370.4" "318.6" "" "" "" "" "" "" "" "" "" "" "338.3" "290.7" "284.2" "249.4" "314.1" "284.0" "316.8" "252.3" "249.8" "318.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831318780158998432" "False" "High" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "0.000" "False" "16.849" "12" "5" "6" "5" "392" "42.9" "7.09" "18.79" "5" "" "other cell component" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "" "2q37 copy number variation syndrome" "1" "0" "0.982" "0.793" "1.073" "0.930" "0.815" "0.968" "0.892" "0.754" "2.469" "244.3" "240.0" "193.7" "262.0" "227.3" "199.1" "236.4" "217.8" "184.2" "603.1" "" "" "" "" "" "" "" "" "" "" "220.5" "185.1" "149.9" "176.4" "189.6" "169.9" "200.6" "157.7" "124.2" "603.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5517326746891322777" "False" "High" "IsMasterProtein" "Q9H2P0" "Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1" "0.000" "False" "16.847" "3" "3" "4" "3" "1102" "123.5" "7.34" "12.89" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00046, Pf19627" "23394" "ENSG00000101126" "ADNP" "E1P5Y2; hsa:23394; O94881; Q5BKU2; Q9H2P0; Q9UG34" "" "" "0" "0" "0.956" "3.031" "1.214" "1.006" "2.983" "0.905" "0.993" "3.095" "2.156" "101.2" "96.8" "306.7" "122.8" "101.8" "301.9" "91.6" "100.5" "313.2" "218.2" "" "" "" "" "" "" "" "" "" "" "91.3" "74.7" "237.2" "82.7" "85.0" "257.7" "77.7" "72.7" "211.2" "218.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5664998384620828706" "False" "High" "IsMasterProtein" "Q13895" "Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3" "0.000" "False" "16.839" "9" "4" "5" "4" "437" "49.6" "8.12" "17.65" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05291" "705" "ENSG00000112578" "BYSL" "hsa:705; Q13895; Q6P5W4; Q86W44; Q96IP8" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.950" "0.715" "0.905" "0.990" "0.764" "0.840" "0.782" "0.687" "2.555" "136.2" "129.5" "97.4" "123.3" "135.0" "104.2" "114.5" "106.5" "93.5" "348.2" "" "" "" "" "" "" "" "" "" "" "123.0" "99.9" "75.3" "83.0" "112.6" "88.9" "97.1" "77.1" "63.1" "348.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3386437626543326564" "False" "High" "IsMasterProtein" "Q9BWE0" "DNA-binding protein REPIN1 OS=Homo sapiens OX=9606 GN=REPIN1 PE=1 SV=1" "0.000" "False" "16.832" "4" "2" "4" "2" "567" "63.5" "9.98" "17.36" "2" "DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "29803" "ENSG00000214022" "REPIN1" "C9J3L7; D3DWZ1; hsa:29803; Q7LE03; Q9BUZ6; Q9BWE0; Q9NZH2; Q9UMP5" "" "" "0" "0" "0.927" "0.791" "0.892" "0.998" "0.867" "0.979" "0.901" "0.830" "0.689" "162.3" "150.4" "128.4" "144.8" "162.0" "140.8" "158.9" "146.2" "134.7" "111.8" "" "" "" "" "" "" "" "" "" "" "146.5" "116.0" "99.3" "97.5" "135.1" "120.2" "134.8" "105.8" "90.8" "111.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7032726270839277036" "False" "High" "IsMasterProtein" "P27144" "Adenylate kinase 4, mitochondrial OS=Homo sapiens OX=9606 GN=AK4 PE=1 SV=1" "0.000" "False" "16.830" "19" "4" "5" "4" "223" "25.3" "8.40" "16.86" "4" "other metabolic processes;stress response;other biological processes" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "205" "ENSG00000162433" "AK4" "B2R927; D3DQ62; hsa:205; P27144; Q6IBH4; Q6NXQ5; Q8IUU9" "Interconversion of nucleotide di- and triphosphates" "CCL18 signaling pathway" "2" "0" "0.931" "0.791" "0.976" "0.894" "0.689" "0.917" "0.898" "0.754" "0.744" "296.0" "275.7" "234.3" "289.0" "264.7" "204.1" "271.5" "265.8" "223.2" "220.2" "" "" "" "" "" "" "" "" "" "" "267.2" "212.6" "181.2" "194.6" "220.8" "174.2" "230.3" "192.3" "150.6" "220.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5390707735378390925" "False" "High" "IsMasterProtein" "Q8IYB3" "Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2" "0.000" "False" "16.825" "5" "4" "4" "4" "904" "102.3" "11.84" "13.71" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf01480" "10250" "ENSG00000133226" "SRRM1" "hsa:10250; O60585; Q5VVN4; Q8IYB3" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "7" "0" "1.208" "1.089" "1.005" "1.059" "0.895" "1.068" "1.020" "1.068" "1.022" "185.1" "223.7" "201.7" "186.0" "196.0" "165.7" "197.7" "188.8" "197.7" "189.1" "" "" "" "" "" "" "" "" "" "" "167.1" "172.5" "156.0" "125.2" "163.5" "141.4" "167.7" "136.6" "133.4" "189.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266332044031462775" "False" "High" "IsMasterProtein" "O43324" "Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1" "0.000" "False" "16.825" "21" "4" "4" "4" "174" "19.8" "8.54" "13.23" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00043" "9521" "ENSG00000124802" "EEF1E1" "C9JLK5; hsa:9521; O43324; Q5THS2" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "" "2" "0" "1.112" "0.859" "0.864" "1.121" "0.742" "1.064" "0.859" "0.862" "3.008" "179.0" "199.0" "153.7" "154.7" "200.7" "132.9" "190.4" "153.7" "154.3" "538.4" "" "" "" "" "" "" "" "" "" "" "161.6" "153.5" "118.9" "104.2" "167.4" "113.4" "161.5" "111.2" "104.1" "538.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-827121188594037217" "False" "High" "IsMasterProtein" "Q6P1R4" "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS1L PE=1 SV=1" "0.000" "False" "16.820" "6" "2" "3" "2" "473" "53.2" "8.29" "9.78" "2" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01207" "64118" "ENSG00000169718" "DUS1L" "A6NHV4; hsa:64118; Q6P1R4; Q96AI3" "" "" "0" "0" "1.325" "0.651" "1.340" "1.121" "0.560" "1.061" "0.954" "0.523" "1.309" "40.4" "53.5" "26.3" "54.1" "45.3" "22.6" "42.8" "38.5" "21.1" "52.8" "" "" "" "" "" "" "" "" "" "" "36.4" "41.3" "20.3" "36.4" "37.8" "19.3" "36.3" "27.9" "14.3" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814198643835656164" "False" "High" "IsMasterProtein" "O60711" "Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1" "0.000" "False" "16.754" "6" "2" "3" "2" "386" "43.3" "6.01" "12.05" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "9404" "ENSG00000110031" "LPXN" "B2R8B4; B4DV71; hsa:9404; O60711; Q53FW6; Q6FI07" "" "" "0" "0" "1.060" "0.937" "1.181" "1.155" "0.961" "1.013" "1.097" "0.929" "1.628" "145.6" "154.3" "136.4" "171.9" "168.1" "139.9" "147.4" "159.7" "135.2" "236.9" "" "" "" "" "" "" "" "" "" "" "131.4" "119.0" "105.5" "115.8" "140.2" "119.4" "125.0" "115.6" "91.2" "236.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815959030617886930" "False" "High" "IsMasterProtein" "O75167" "Phosphatase and actin regulator 2 OS=Homo sapiens OX=9606 GN=PHACTR2 PE=1 SV=2" "0.000" "False" "16.750" "7" "4" "6" "4" "634" "69.7" "8.16" "13.87" "4" "cell organization and biogenesis" "plasma membrane;other membranes" "enzyme regulator activity;cytoskeletal activity" "Pf02755" "9749" "ENSG00000112419" "PHACTR2" "A6NKP5; A7MCZ5; A8MZC0; B2RWP7; B4DN76; B4DPB5; B4DTH7; hsa:9749; O75167; Q5TFA0; Q68DM2" "Platelet degranulation" "" "1" "0" "1.065" "1.130" "1.062" "1.108" "0.954" "1.058" "1.007" "1.088" "0.778" "260.3" "277.3" "294.2" "276.4" "288.5" "248.3" "275.3" "262.0" "283.2" "202.4" "" "" "" "" "" "" "" "" "" "" "235.0" "213.9" "227.6" "186.1" "240.6" "211.9" "233.5" "189.6" "191.0" "202.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2630091394541072843" "False" "High" "IsMasterProtein" "Q9P2Y5" "UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1" "0.000" "False" "16.746" "8" "6" "6" "6" "699" "78.1" "8.29" "17.49" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf10186" "7405" "ENSG00000198382" "UVRAG" "B3KTC1; hsa:7405; O00392; Q9P2Y5" "Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; SARS-CoV-2 modulates autophagy" "Nanoparticle triggered autophagic cell death; Autophagy" "6" "0" "0.910" "0.935" "0.913" "1.005" "0.906" "0.967" "0.995" "0.974" "1.203" "300.0" "272.9" "280.5" "273.7" "301.5" "271.6" "289.9" "298.4" "292.1" "361.0" "" "" "" "" "" "" "" "" "" "" "270.8" "210.5" "217.0" "184.3" "251.5" "231.9" "245.9" "215.9" "197.0" "361.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1726456948051343577" "False" "High" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "0.000" "False" "16.737" "6" "4" "5" "4" "650" "72.5" "8.05" "14.49" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "0.925" "0.686" "0.986" "1.002" "0.671" "0.870" "0.893" "0.774" "1.778" "158.2" "146.4" "108.6" "155.9" "158.5" "106.1" "137.7" "141.2" "122.5" "281.2" "" "" "" "" "" "" "" "" "" "" "142.8" "112.9" "84.0" "105.0" "132.2" "90.6" "116.8" "102.2" "82.6" "281.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5837225809424381126" "False" "High" "IsMasterProtein" "P51826" "AF4/FMR2 family member 3 OS=Homo sapiens OX=9606 GN=AFF3 PE=1 SV=3" "0.000" "False" "16.724" "2" "2" "2" "2" "1226" "133.4" "8.10" "8.50" "2" "developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05110, Pf18875, Pf18876" "3899" "ENSG00000144218" "AFF3" "B7ZM46; B9EGL9; D3DVI6; P51826; Q53RD6; Q53S47; Q53SI6; Q53TB9; Q59F27; Q8IWJ5" "" "" "0" "0" "1.062" "0.997" "1.028" "1.116" "0.960" "0.901" "1.054" "0.937" "0.768" "85.1" "90.4" "84.9" "87.5" "95.0" "81.7" "76.7" "89.8" "79.8" "65.4" "" "" "" "" "" "" "" "" "" "" "76.9" "69.8" "65.7" "58.9" "79.2" "69.8" "65.1" "65.0" "53.8" "65.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "908398624639479548" "False" "High" "IsMasterProtein" "P62913" "Large ribosomal subunit protein uL5 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "0.000" "False" "16.697" "25" "5" "8" "5" "178" "20.2" "9.60" "23.05" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "MET in type 1 papillary renal cell carcinoma; Cytoplasmic ribosomal proteins" "15" "0" "0.921" "0.990" "0.891" "0.929" "0.851" "1.020" "0.988" "0.898" "0.308" "414.6" "381.8" "410.6" "369.4" "385.2" "352.8" "422.7" "409.6" "372.3" "127.7" "" "" "" "" "" "" "" "" "" "" "374.2" "294.5" "317.5" "248.8" "321.3" "301.1" "358.6" "296.4" "251.1" "127.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3273487821867758056" "False" "High" "IsMasterProtein" "Q96DV4" "Large ribosomal subunit protein mL38 OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" "0.000" "False" "16.695" "12" "4" "4" "4" "380" "44.6" "7.53" "13.16" "4" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf01161" "64978" "ENSG00000204316" "MRPL38" "B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.976" "0.847" "0.994" "1.015" "0.869" "1.004" "0.954" "0.801" "0.884" "272.7" "266.1" "231.1" "271.1" "276.8" "237.0" "273.9" "260.3" "218.4" "241.2" "" "" "" "" "" "" "" "" "" "" "246.2" "205.3" "178.7" "182.6" "230.9" "202.3" "232.4" "188.4" "147.3" "241.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602671086497481481" "False" "High" "IsMasterProtein" "O43709" "18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "0.000" "False" "16.693" "17" "4" "6" "4" "281" "31.9" "8.73" "19.94" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "7q11.23 copy number variation syndrome" "3" "0" "1.030" "0.838" "0.931" "1.031" "0.919" "0.840" "0.946" "0.932" "0.771" "263.3" "271.1" "220.6" "245.0" "271.4" "242.0" "221.2" "249.0" "245.3" "203.0" "" "" "" "" "" "" "" "" "" "" "237.7" "209.1" "170.6" "165.0" "226.4" "206.6" "187.6" "180.2" "165.4" "203.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7656229856008546485" "False" "High" "IsMasterProtein" "O95453" "Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1" "0.000" "False" "16.671" "8" "6" "7" "6" "639" "73.4" "6.20" "17.46" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857, Pf08675" "5073" "ENSG00000140694; ENSG00000274829" "PARN" "B2RCB3; B4DDG8; B4DSB0; B4DWR4; B4E1H6; hsa:5073; O95453" "Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "Lung fibrosis" "4" "0" "0.983" "0.878" "1.245" "1.026" "0.930" "1.034" "1.067" "1.003" "1.451" "76.2" "74.9" "66.9" "94.8" "78.2" "70.9" "78.7" "81.3" "76.4" "110.5" "" "" "" "" "" "" "" "" "" "" "68.8" "57.8" "51.7" "63.9" "65.2" "60.5" "66.8" "58.8" "51.5" "110.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7653373487496169859" "False" "High" "IsMasterProtein" "Q4VC05" "B-cell CLL/lymphoma 7 protein family member A OS=Homo sapiens OX=9606 GN=BCL7A PE=1 SV=1" "0.000" "False" "16.656" "18" "4" "4" "4" "210" "22.8" "5.14" "14.41" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf04714" "605" "ENSG00000110987" "BCL7A" "B4DJN6; B7ZB21; hsa:605; Q13843; Q14CT7; Q4VC05" "" "" "0" "0" "1.096" "1.112" "1.137" "1.086" "1.080" "1.035" "1.081" "1.104" "1.274" "114.7" "125.7" "127.5" "130.4" "124.5" "123.8" "118.6" "123.9" "126.6" "146.1" "" "" "" "" "" "" "" "" "" "" "103.5" "97.0" "98.6" "87.8" "103.9" "105.7" "100.6" "89.7" "85.4" "146.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1941330484708974901" "False" "High" "IsMasterProtein" "P18621" "Large ribosomal subunit protein uL22 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "0.000" "False" "16.655" "18" "4" "7" "3" "184" "21.4" "10.17" "22.39" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.827" "1.137" "0.904" "0.957" "0.947" "0.979" "0.938" "0.978" "0.325" "826.0" "682.7" "939.1" "746.3" "790.4" "782.5" "808.6" "775.1" "807.5" "268.7" "" "" "" "" "" "" "" "" "" "" "745.6" "526.6" "726.3" "502.6" "659.3" "667.9" "685.9" "560.9" "544.6" "268.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4417786093828078874" "False" "High" "IsMasterProtein" "Q9H1A4" "Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1" "0.000" "False" "16.642" "3" "7" "7" "7" "1944" "216.4" "6.30" "20.63" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12859, Pf18122, Pf20518, Pf21282" "64682" "ENSG00000153107" "ANAPC1" "hsa:64682; Q2M3H8; Q9BSE6; Q9H1A4; Q9H8D0" "Senescence-Associated Secretory Phenotype (SASP); Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle; 2q13 copy number variation syndrome" "20" "0" "0.927" "0.693" "1.084" "1.012" "0.721" "0.953" "0.944" "0.842" "1.397" "144.9" "134.4" "100.4" "157.1" "146.6" "104.5" "138.1" "136.7" "122.0" "202.3" "" "" "" "" "" "" "" "" "" "" "130.8" "103.6" "77.6" "105.8" "122.3" "89.2" "117.2" "99.0" "82.3" "202.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8124726233717471609" "False" "High" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "0.000" "False" "16.633" "10" "4" "7" "3" "372" "42.8" "8.79" "21.17" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "20" "0" "0.858" "0.841" "0.906" "1.009" "0.984" "0.868" "0.841" "0.691" "1.389" "62.9" "54.0" "52.9" "57.0" "63.5" "61.9" "54.6" "52.9" "43.5" "87.4" "" "" "" "" "" "" "" "" "" "" "56.8" "41.6" "40.9" "38.4" "52.9" "52.8" "46.3" "38.3" "29.3" "87.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4879961638611313513" "False" "High" "IsMasterProtein" "Q12765" "Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2" "0.000" "False" "16.606" "8" "3" "5" "3" "414" "46.4" "4.75" "16.52" "3" "protein metabolism;transport;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03577" "9805" "ENSG00000136193" "SCRN1" "A8K0E9; B4DHM0; B4DIP5; C9JPG0; hsa:9805; Q12765; Q25QX7; Q8IWD1" "" "" "0" "0" "1.059" "0.922" "1.070" "1.123" "0.918" "0.981" "1.042" "0.838" "0.951" "192.2" "203.6" "177.3" "205.6" "215.8" "176.4" "188.6" "200.3" "161.0" "182.7" "" "" "" "" "" "" "" "" "" "" "173.5" "157.1" "137.1" "138.5" "180.0" "150.5" "160.0" "145.0" "108.6" "182.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5817906340983341960" "False" "High" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "0.000" "False" "16.597" "23" "2" "6" "2" "95" "10.9" "5.50" "21.99" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "SUMOylation of chromatin organization proteins; SUMOylation of intracellular receptors; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "TAR syndrome" "15" "0" "0.863" "1.103" "0.950" "0.899" "1.146" "0.930" "0.915" "1.108" "1.250" "384.2" "331.5" "423.8" "365.0" "345.3" "440.5" "357.5" "351.4" "425.9" "480.4" "" "" "" "" "" "" "" "" "" "" "346.8" "255.7" "327.8" "245.8" "288.1" "375.9" "303.2" "254.3" "287.2" "480.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311027039317612116" "False" "High" "IsMasterProtein" "Q9Y3B8" "Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3" "0.000" "False" "16.593" "12" "3" "5" "3" "237" "26.8" "6.87" "15.69" "3" "DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "25996" "ENSG00000076043" "REXO2" "B2R532; hsa:25996; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; Q9Y3B8" "Mitochondrial RNA degradation" "" "1" "0" "0.959" "0.995" "1.029" "0.945" "1.041" "0.977" "1.055" "0.983" "0.653" "391.2" "375.1" "389.1" "402.4" "369.6" "407.1" "382.2" "412.8" "384.4" "255.4" "" "" "" "" "" "" "" "" "" "" "353.1" "289.4" "300.9" "270.9" "308.3" "347.4" "324.3" "298.7" "259.3" "255.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100137965290358990" "False" "High" "IsMasterProtein" "Q9UJW0" "Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1" "0.000" "False" "16.584" "10" "3" "3" "3" "460" "52.3" "7.34" "8.83" "3" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05502" "51164" "ENSG00000132912" "DCTN4" "B3KWW0; D3DQH0; E5RGT5; hsa:51164; Q8TAN8; Q9UJW0" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "Vasopressin-regulated water reabsorption" "5" "0" "0.854" "0.986" "0.925" "1.026" "1.097" "0.950" "0.969" "1.116" "0.937" "39.4" "33.7" "38.9" "36.5" "40.5" "43.3" "37.5" "38.2" "44.0" "37.0" "" "" "" "" "" "" "" "" "" "" "35.6" "26.0" "30.1" "24.6" "33.8" "36.9" "31.8" "27.7" "29.7" "37.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2093622572460603588" "False" "High" "IsMasterProtein" "Q8NBF6" "Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1" "0.000" "False" "16.583" "7" "4" "5" "4" "648" "71.9" "6.21" "13.54" "4" "other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf09794" "23080" "ENSG00000105778" "AVL9" "hsa:23080; Q8NBF6; Q92573" "" "" "0" "0" "0.827" "0.933" "1.055" "0.954" "1.035" "0.915" "0.865" "0.847" "0.933" "81.3" "67.2" "75.8" "85.7" "77.5" "84.1" "74.4" "70.3" "68.8" "75.8" "" "" "" "" "" "" "" "" "" "" "73.3" "51.8" "58.6" "57.7" "64.7" "71.8" "63.1" "50.9" "46.4" "75.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-200305812606160804" "False" "High" "IsMasterProtein" "Q3MHD2" "Protein LSM12 OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2" "0.000" "False" "16.579" "11" "2" "3" "2" "195" "21.7" "7.74" "11.48" "2" "" "other cell component" "nucleic acid binding activity" "Pf09793, Pf21166" "124801" "ENSG00000161654" "LSM12" "hsa:124801; Q3MHD2; Q86YB1; Q96NL5" "" "" "0" "0" "0.978" "0.992" "0.969" "1.080" "1.046" "1.036" "1.091" "1.059" "1.168" "187.2" "183.1" "185.7" "181.4" "202.2" "195.9" "194.0" "204.3" "198.2" "218.6" "" "" "" "" "" "" "" "" "" "" "169.0" "141.3" "143.6" "122.2" "168.7" "167.2" "164.6" "147.8" "133.7" "218.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634668291009869452" "False" "High" "IsMasterProtein" "Q9UNP9" "Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1" "0.000" "False" "16.563" "14" "4" "4" "3" "301" "33.4" "5.60" "12.62" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00160" "10450" "ENSG00000084072" "PPIE" "B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9" "mRNA Splicing - Major Pathway; Neutrophil degranulation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "" "6" "0" "1.021" "1.134" "1.025" "1.017" "1.219" "0.960" "0.910" "1.119" "1.773" "169.2" "172.7" "191.8" "173.5" "172.0" "206.3" "162.3" "154.0" "189.4" "299.9" "" "" "" "" "" "" "" "" "" "" "152.7" "133.2" "148.3" "116.8" "143.5" "176.1" "137.7" "111.5" "127.7" "299.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-253239951813173210" "False" "High" "IsMasterProtein" "Q9H2M9" "Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1" "0.000" "False" "16.555" "3" "5" "5" "4" "1393" "155.9" "5.62" "11.65" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf14655, Pf14656" "25782" "ENSG00000118873" "RAB3GAP2" "A6H8V0; hsa:25782; O75872; Q9H2M9; Q9HAB0; Q9UFJ7; Q9UQ15" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "" "2" "0" "0.978" "1.053" "1.069" "0.880" "1.080" "1.041" "0.703" "1.069" "5.006" "175.0" "171.1" "184.3" "187.2" "154.1" "189.1" "182.2" "123.0" "187.1" "876.2" "" "" "" "" "" "" "" "" "" "" "158.0" "132.0" "142.6" "126.0" "128.5" "161.4" "154.6" "89.0" "126.2" "876.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1607467674154274672" "False" "High" "IsMasterProtein" "Q8N4Q1" "Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1" "0.000" "False" "16.552" "22" "3" "6" "2" "142" "16.0" "4.31" "20.85" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "mitochondrion" "other molecular function" "Pf06747" "131474" "ENSG00000163528" "CHCHD4" "A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6" "Mitochondrial protein import" "" "1" "1" "0.964" "1.080" "1.067" "0.929" "1.053" "0.899" "1.134" "1.179" "0.762" "215.0" "207.3" "232.3" "229.3" "199.7" "226.4" "193.3" "243.8" "253.4" "163.8" "" "" "" "" "" "" "" "" "" "" "194.0" "159.9" "179.6" "154.4" "166.6" "193.2" "164.0" "176.5" "170.9" "163.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6945972540220555835" "False" "High" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "0.000" "False" "16.548" "4" "5" "5" "5" "1273" "145.1" "7.25" "15.80" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; NoRC negatively regulates rRNA expression; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by PPARalpha; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway; 15q11q13 copy number variation" "19" "0" "1.128" "1.863" "1.470" "1.356" "1.839" "1.346" "0.995" "1.985" "2.849" "39.2" "44.2" "73.0" "57.6" "53.2" "72.1" "52.8" "39.0" "77.8" "111.7" "" "" "" "" "" "" "" "" "" "" "35.4" "34.1" "56.5" "38.8" "44.3" "61.5" "44.8" "28.2" "52.5" "111.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4822956659812595428" "False" "High" "IsMasterProtein" "P17706" "Tyrosine-protein phosphatase non-receptor type 2 OS=Homo sapiens OX=9606 GN=PTPN2 PE=1 SV=2" "0.000" "False" "16.543" "11" "4" "5" "4" "415" "48.4" "8.29" "15.32" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5771" "ENSG00000175354" "PTPN2" "A8K955; A8MXU3; hsa:5771; K7ENG3; P17706; Q96AU5; Q96HR2" "PKR-mediated signaling; Negative regulation of MET activity; Interleukin-37 signaling" "Immune response to tuberculosis; 5q35 copy number variation" "5" "0" "0.864" "0.955" "1.081" "1.125" "0.838" "1.070" "0.815" "0.716" "4.123" "71.8" "62.0" "68.6" "77.6" "80.8" "60.2" "76.8" "58.5" "51.4" "296.0" "" "" "" "" "" "" "" "" "" "" "64.8" "47.8" "53.0" "52.3" "67.4" "51.4" "65.2" "42.3" "34.7" "296.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7828842707520281021" "False" "High" "IsMasterProtein" "P41223" "Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2" "0.000" "False" "16.536" "26" "4" "6" "4" "144" "17.0" "8.82" "19.06" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01125" "8896" "ENSG00000106245" "BUD31" "A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1" "mRNA Splicing - Major Pathway" "" "1" "0" "0.921" "0.857" "0.950" "0.986" "1.048" "1.032" "1.044" "0.940" "0.757" "270.3" "249.0" "231.5" "256.8" "266.5" "283.1" "278.8" "282.1" "254.2" "204.7" "" "" "" "" "" "" "" "" "" "" "244.0" "192.1" "179.1" "172.9" "222.3" "241.7" "236.5" "204.1" "171.4" "204.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8751597953454221886" "False" "High" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "0.000" "False" "16.531" "19" "6" "13" "6" "248" "27.1" "4.51" "39.29" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "Recycling pathway of L1; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "17" "0" "0.900" "0.935" "0.970" "0.871" "0.989" "0.896" "1.098" "0.946" "0.664" "593.1" "533.7" "554.8" "575.4" "516.8" "586.9" "531.7" "651.2" "561.3" "393.9" "" "" "" "" "" "" "" "" "" "" "535.4" "411.7" "429.1" "387.5" "431.1" "500.9" "451.0" "471.2" "378.6" "393.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8154313858001218704" "False" "High" "IsMasterProtein" "Q8IWZ3" "Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1" "0.000" "False" "16.531" "2" "5" "6" "3" "2542" "269.3" "5.73" "11.39" "5" "stress response" "other cell component" "" "Pf00013, Pf12796, Pf13637" "404734; 54882" "ENSG00000131503" "ANKHD1" "A6NH85; hsa:404734; hsa:54882; Q149P2; Q8IWZ2; Q8IWZ3; Q8WY90; Q96G77; Q96GK0; Q9H2U0; Q9HA95; Q9NWG4; Q9UPR7" "" "" "0" "0" "0.861" "0.886" "1.120" "0.831" "0.828" "0.792" "0.244" "0.909" "8.542" "84.5" "72.8" "74.9" "94.7" "70.3" "70.0" "67.0" "20.6" "76.8" "721.9" "" "" "" "" "" "" "" "" "" "" "76.3" "56.1" "57.9" "63.8" "58.6" "59.7" "56.8" "14.9" "51.8" "721.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "123318016964233677" "False" "High" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "0.000" "False" "16.507" "10" "2" "5" "2" "264" "30.2" "7.50" "14.47" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "RHOG GTPase cycle; Complex I biogenesis; Mitochondrial protein degradation" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "1.053" "1.082" "1.260" "0.998" "1.088" "1.108" "1.013" "1.182" "1.223" "96.4" "101.6" "104.3" "121.4" "96.3" "104.8" "106.8" "97.7" "113.9" "117.9" "" "" "" "" "" "" "" "" "" "" "87.0" "78.3" "80.7" "81.8" "80.3" "89.5" "90.6" "70.7" "76.8" "117.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949132700508493695" "False" "High" "IsMasterProtein" "Q8WW59" "SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=3" "0.000" "False" "16.504" "21" "4" "4" "4" "207" "23.1" "6.93" "11.74" "4" "" "nucleus" "" "Pf00622" "283377" "ENSG00000176422" "SPRYD4" "A8K7A5; hsa:283377; Q8WW59" "" "" "0" "0" "0.819" "0.899" "0.992" "0.808" "0.907" "0.940" "0.907" "1.081" "0.706" "159.3" "130.5" "143.2" "158.1" "128.7" "144.6" "149.7" "144.6" "172.2" "112.5" "" "" "" "" "" "" "" "" "" "" "143.8" "100.7" "110.8" "106.5" "107.4" "123.4" "127.0" "104.6" "116.1" "112.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408617602849881412" "False" "High" "IsMasterProtein" "Q9UKU7" "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1" "0.000" "False" "16.499" "9" "3" "3" "3" "415" "45.0" "7.85" "9.79" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "27034" "ENSG00000151498" "ACAD8" "B7Z5W4; hsa:27034; Q6ZWP6; Q9BUS8; Q9UKU7" "Branched-chain amino acid catabolism; Mitochondrial protein degradation" "" "2" "0" "1.001" "0.953" "1.075" "1.073" "1.082" "1.054" "1.008" "1.058" "0.822" "179.2" "179.3" "170.8" "192.7" "192.3" "194.0" "189.0" "180.6" "189.6" "147.3" "" "" "" "" "" "" "" "" "" "" "161.8" "138.3" "132.1" "129.7" "160.4" "165.6" "160.3" "130.7" "127.9" "147.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233128446451314475" "False" "High" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "0.000" "False" "16.496" "15" "5" "5" "5" "361" "40.8" "5.25" "14.53" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "0.727" "1.020" "1.238" "0.927" "1.036" "1.040" "0.905" "0.763" "2.172" "11.5" "8.4" "11.7" "14.2" "10.7" "11.9" "12.0" "10.4" "8.8" "25.0" "" "" "" "" "" "" "" "" "" "" "10.4" "6.4" "9.1" "9.6" "8.9" "10.2" "10.1" "7.5" "5.9" "25.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8995657341512938219" "False" "High" "IsMasterProtein" "P47914" "Large ribosomal subunit protein eL29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "0.000" "False" "16.483" "14" "2" "5" "2" "159" "17.7" "11.66" "13.99" "2" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.839" "0.896" "0.862" "1.039" "0.956" "1.096" "1.041" "0.966" "0.247" "138.0" "115.8" "123.6" "119.0" "143.3" "132.0" "151.3" "143.6" "133.3" "34.1" "" "" "" "" "" "" "" "" "" "" "124.6" "89.3" "95.6" "80.1" "119.5" "112.6" "128.3" "103.9" "89.9" "34.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1214418954468839603" "False" "High" "IsMasterProtein" "Q96C01" "Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1" "0.000" "False" "16.478" "25" "4" "5" "4" "138" "15.6" "7.61" "18.71" "4" "" "other cell component" "" "Pf05811" "84908" "ENSG00000035141" "FAM136A" "hsa:84908; Q96C01; Q96SS3" "" "" "0" "0" "0.985" "0.790" "0.918" "0.935" "0.709" "1.030" "1.183" "0.697" "0.678" "802.7" "790.8" "634.0" "736.7" "750.3" "569.5" "827.2" "949.9" "559.8" "544.2" "" "" "" "" "" "" "" "" "" "" "724.6" "610.0" "490.4" "496.1" "625.8" "486.1" "701.7" "687.4" "377.6" "544.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8252267867784187079" "False" "High" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "0.000" "False" "16.478" "6" "3" "4" "2" "633" "68.0" "9.94" "12.64" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "" "6" "0" "0.896" "0.925" "1.349" "0.995" "1.186" "1.034" "1.138" "1.060" "2.402" "48.0" "43.0" "44.4" "64.7" "47.8" "56.9" "49.6" "54.6" "50.8" "115.3" "" "" "" "" "" "" "" "" "" "" "43.3" "33.2" "34.3" "43.6" "39.8" "48.6" "42.1" "39.5" "34.3" "115.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012550924560015135" "False" "High" "IsMasterProtein" "O43805" "Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2" "0.000" "False" "16.429" "23" "3" "4" "3" "119" "13.6" "5.38" "12.93" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "8636" "ENSG00000176101" "SSNA1" "hsa:8636; O43805; Q5VSG0; Q6FG70; Q9BVW8" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Ciliary landscape" "8" "0" "0.858" "0.789" "1.020" "0.986" "0.888" "0.842" "0.823" "1.088" "0.876" "46.6" "40.0" "36.7" "47.5" "45.9" "41.3" "39.2" "38.3" "50.7" "40.8" "" "" "" "" "" "" "" "" "" "" "42.0" "30.8" "28.4" "32.0" "38.3" "35.3" "33.3" "27.7" "34.2" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7649239600803351534" "False" "High" "IsMasterProtein" "Q96JY6" "PDZ and LIM domain protein 2 OS=Homo sapiens OX=9606 GN=PDLIM2 PE=1 SV=1" "0.000" "False" "16.410" "9" "3" "3" "3" "352" "37.4" "8.72" "12.66" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "64236" "ENSG00000120913" "PDLIM2" "D3DSR5; hsa:64236; J3KNH4; Q7Z584; Q86WM8; Q8WZ29; Q96JY6; Q9H4L9; Q9H7I2" "" "" "0" "0" "1.018" "1.000" "1.048" "1.080" "1.023" "1.201" "1.215" "0.982" "1.000" "265.9" "270.7" "266.0" "278.5" "287.1" "271.9" "319.4" "323.0" "261.1" "265.9" "" "" "" "" "" "" "" "" "" "" "240.0" "208.8" "205.7" "187.6" "239.5" "232.1" "270.9" "233.7" "176.1" "265.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4254593612476960216" "False" "High" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "0.000" "False" "16.390" "13" "4" "4" "4" "278" "29.5" "8.56" "13.61" "4" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "Peroxisomal protein import; RA biosynthesis pathway" "" "2" "0" "1.056" "1.041" "1.072" "1.108" "1.026" "0.992" "1.130" "0.939" "0.747" "89.3" "94.3" "93.0" "95.7" "99.0" "91.6" "88.6" "100.9" "83.9" "66.7" "" "" "" "" "" "" "" "" "" "" "80.6" "72.7" "71.9" "64.5" "82.6" "78.2" "75.2" "73.0" "56.6" "66.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196363809325094679" "False" "High" "IsMasterProtein" "Q9HCU8" "DNA polymerase delta subunit 4 OS=Homo sapiens OX=9606 GN=POLD4 PE=1 SV=1" "0.000" "False" "16.364" "23" "2" "3" "2" "107" "12.4" "6.77" "11.68" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf04081" "57804" "ENSG00000175482" "POLD4" "F5H506; hsa:57804; Q9HCU8" "Dual Incision in GG-NER; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "25" "0" "1.026" "0.737" "0.914" "0.967" "0.897" "0.969" "0.987" "0.700" "0.598" "142.4" "146.0" "105.0" "130.1" "137.7" "127.8" "137.9" "140.6" "99.7" "85.2" "" "" "" "" "" "" "" "" "" "" "128.5" "112.6" "81.2" "87.6" "114.8" "109.1" "117.0" "101.8" "67.2" "85.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2141575905927618539" "False" "High" "IsMasterProtein" "P79483" "HLA class II histocompatibility antigen, DR beta 3 chain OS=Homo sapiens OX=9606 GN=HLA-DRB3 PE=1 SV=1" "0.000" "False" "16.352" "15" "4" "5" "3" "266" "29.9" "8.56" "18.19" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3125" "ENSG00000196101; ENSG00000231679" "HLA-DRB3" "A0ZXY9; A7MA46; B5AU12; B5AU13; B5AU14; B8YAC6; C6H115; C6H116; O02875; O19590; O46701; O46794; O78049; O78162; P01913; P79483; P79663; Q29721; Q29809; Q2PPD0; Q30144; Q507L8; Q5SP44; Q5STE0; Q6YJU6; Q70M87; Q7YQ62; Q860I9; Q8SP69; Q8WLT7; Q8WLT8; Q95359; Q95HM8; Q95IE5; Q96H16; Q9BCP3; Q9BD18; Q9MYA4; Q9MYH3; Q9MYH4; Q9TP01; Q9TP02; Q9TPB5; Q9TQ21; Q9UIN3; Q9UIN5" "MHC class II antigen presentation; Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Downstream TCR signaling; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host" "9" "0" "1.118" "1.078" "1.111" "0.925" "1.007" "1.029" "1.275" "1.083" "0.737" "202.5" "226.4" "218.3" "225.0" "187.4" "203.9" "208.4" "258.2" "219.4" "149.2" "" "" "" "" "" "" "" "" "" "" "182.8" "174.6" "168.9" "151.5" "156.3" "174.0" "176.8" "186.9" "148.0" "149.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4353457585173966729" "False" "High" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "0.000" "False" "16.324" "31" "3" "11" "3" "59" "6.9" "10.45" "33.19" "3" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "1.107" "0.890" "1.219" "1.110" "0.904" "1.059" "1.264" "0.905" "0.692" "442.3" "489.7" "393.8" "539.0" "490.9" "399.6" "468.3" "558.9" "400.5" "306.0" "" "" "" "" "" "" "" "" "" "" "399.3" "377.8" "304.6" "363.0" "409.5" "341.1" "397.2" "404.5" "270.1" "306.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835883825689200365" "False" "High" "IsMasterProtein" "Q92979" "Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4" "0.000" "False" "16.315" "17" "4" "5" "4" "244" "26.7" "9.17" "16.32" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03587" "10436" "ENSG00000126749" "EMG1" "hsa:10436; O00675; O00726; Q92979" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.074" "1.150" "0.970" "1.050" "1.152" "0.977" "0.956" "1.188" "0.609" "426.5" "458.2" "490.5" "413.7" "447.9" "491.5" "416.8" "407.9" "506.8" "259.6" "" "" "" "" "" "" "" "" "" "" "385.0" "353.4" "379.4" "278.6" "373.7" "419.5" "353.6" "295.2" "341.8" "259.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3312961601966625911" "False" "High" "IsMasterProtein" "Q96EY8" "Corrinoid adenosyltransferase MMAB OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1" "0.000" "False" "16.305" "18" "4" "4" "4" "250" "27.4" "8.60" "13.95" "4" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01923" "326625" "ENSG00000139428" "MMAB" "C5HU05; hsa:326625; Q96EY8; Q9BSH0" "Cobalamin (Cbl) metabolism; Defective MMAB causes MMA, cblB type" "Vitamin B12 metabolism" "3" "0" "0.902" "1.003" "1.058" "0.984" "0.928" "0.976" "0.965" "1.033" "0.869" "170.7" "153.9" "171.2" "180.5" "167.9" "158.4" "166.7" "164.7" "176.4" "148.3" "" "" "" "" "" "" "" "" "" "" "154.1" "118.7" "132.4" "121.6" "140.1" "135.2" "141.4" "119.2" "119.0" "148.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6538585977691412019" "False" "High" "IsMasterProtein" "Q9BYB4" "Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2" "0.000" "False" "16.260" "12" "4" "5" "4" "327" "35.6" "7.97" "16.05" "4" "" "" "" "Pf00400" "54584" "ENSG00000185838" "GNB1L" "hsa:54584; Q9BYB4; Q9H2S2; Q9H4M4" "" "22q11.2 copy number variation syndrome" "1" "0" "0.959" "0.823" "1.227" "0.943" "0.852" "0.967" "0.969" "0.926" "0.688" "226.9" "217.6" "186.8" "278.4" "214.1" "193.3" "219.4" "219.8" "210.1" "156.0" "" "" "" "" "" "" "" "" "" "" "204.8" "167.8" "144.5" "187.5" "178.6" "165.0" "186.1" "159.1" "141.7" "156.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-445851658510322323" "False" "High" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "0.000" "False" "16.256" "27" "3" "3" "3" "128" "14.2" "8.46" "11.68" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "mRNA processing" "4" "0" "1.110" "1.083" "1.130" "1.147" "1.278" "1.120" "1.104" "1.165" "0.939" "274.3" "304.5" "297.1" "310.0" "314.5" "350.6" "307.1" "302.7" "319.4" "257.5" "" "" "" "" "" "" "" "" "" "" "247.6" "234.9" "229.8" "208.8" "262.3" "299.2" "260.5" "219.1" "215.4" "257.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5788074156748143009" "False" "High" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "0.000" "False" "16.211" "11" "5" "8" "5" "420" "46.3" "7.21" "25.49" "5" "other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "Synthesis of GDP-mannose" "N-glycan biosynthesis" "2" "0" "0.964" "0.985" "1.095" "1.027" "0.921" "1.003" "0.842" "0.981" "0.754" "283.3" "273.0" "278.9" "310.2" "291.0" "261.0" "284.0" "238.7" "277.9" "213.6" "" "" "" "" "" "" "" "" "" "" "255.7" "210.6" "215.7" "208.9" "242.8" "222.8" "241.0" "172.7" "187.4" "213.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4269157593658569788" "False" "High" "IsMasterProtein" "Q9NXV2" "BTB/POZ domain-containing protein KCTD5 OS=Homo sapiens OX=9606 GN=KCTD5 PE=1 SV=1" "0.000" "False" "16.208" "13" "3" "3" "3" "234" "26.1" "6.24" "11.35" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02214" "54442" "ENSG00000167977" "KCTD5" "D3DU96; hsa:54442; Q9NXV2" "" "" "0" "0" "0.986" "0.743" "1.029" "1.038" "0.861" "0.901" "0.951" "0.836" "0.720" "220.4" "217.4" "163.8" "226.9" "228.9" "189.8" "198.6" "209.6" "184.4" "158.6" "" "" "" "" "" "" "" "" "" "" "199.0" "167.7" "126.7" "152.8" "190.9" "162.0" "168.5" "151.7" "124.4" "158.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3551068469878704149" "False" "High" "IsMasterProtein" "Q9H0U6" "Large ribosomal subunit protein uL18m OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1" "0.000" "False" "16.201" "17" "3" "3" "3" "180" "20.6" "9.54" "11.32" "3" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00861" "29074" "ENSG00000112110" "MRPL18" "hsa:29074; Q5TAP9; Q9H0U6; Q9NZW8" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "" "3" "0" "0.969" "0.820" "1.077" "1.005" "1.006" "1.008" "0.974" "0.849" "0.838" "222.1" "215.3" "182.1" "239.2" "223.2" "223.3" "223.9" "216.2" "188.6" "186.2" "" "" "" "" "" "" "" "" "" "" "200.5" "166.1" "140.8" "161.1" "186.2" "190.6" "189.9" "156.5" "127.2" "186.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097658218394758056" "False" "High" "IsMasterProtein" "P54259" "Atrophin-1 OS=Homo sapiens OX=9606 GN=ATN1 PE=1 SV=3" "0.000" "False" "16.189" "4" "5" "5" "4" "1190" "125.3" "8.98" "12.27" "5" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03154" "1822" "ENSG00000111676" "ATN1" "hsa:1822; P54259; Q99495; Q99621; Q9UEK7" "Regulation of PTEN gene transcription" "" "1" "0" "0.994" "1.218" "1.033" "0.887" "1.579" "1.045" "0.777" "1.550" "0.865" "15.9" "15.8" "19.4" "16.4" "14.1" "25.1" "16.6" "12.4" "24.6" "13.7" "" "" "" "" "" "" "" "" "" "" "14.3" "12.2" "15.0" "11.1" "11.8" "21.4" "14.1" "8.9" "16.6" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1787588940823929001" "False" "High" "IsMasterProtein" "P61224" "Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1" "0.000" "False" "16.144" "20" "4" "4" "4" "184" "20.8" "5.78" "12.03" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5908" "ENSG00000127314" "RAP1B" "B2R5Z2; B4DQI8; B4DW74; B4DW94; hsa:5908; P09526; P61224; Q502X3; Q5TZR4; Q6DCA1; Q6LES0" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling" "26" "0" "1.019" "1.118" "1.097" "1.056" "0.964" "1.014" "1.026" "1.018" "0.631" "357.9" "364.7" "400.2" "392.5" "377.9" "345.1" "363.0" "367.2" "364.4" "226.0" "" "" "" "" "" "" "" "" "" "" "323.0" "281.3" "309.6" "264.3" "315.2" "294.5" "307.9" "265.7" "245.8" "226.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656121017139874826" "False" "High" "IsMasterProtein" "Q01081" "Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3" "0.000" "False" "16.138" "9" "2" "4" "2" "240" "27.9" "8.81" "15.62" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00642" "102724594; 7307" "ENSG00000160201" "U2AF1" "hsa:102724594; hsa:7307; Q01081; Q701P4; Q71RF1" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript" "mRNA processing" "5" "0" "0.923" "1.016" "0.952" "1.049" "0.987" "0.956" "0.604" "0.931" "5.414" "84.6" "78.0" "85.9" "80.5" "88.7" "83.4" "80.8" "51.1" "78.7" "457.8" "" "" "" "" "" "" "" "" "" "" "76.3" "60.2" "66.5" "54.2" "74.0" "71.2" "68.6" "37.0" "53.1" "457.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844902181037291409" "False" "High" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "0.000" "False" "16.134" "20" "3" "6" "3" "119" "13.3" "11.56" "20.04" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "mRNA processing" "5" "0" "1.114" "1.069" "1.001" "0.852" "1.135" "0.842" "1.049" "0.921" "0.874" "187.6" "208.9" "200.5" "187.8" "159.8" "212.9" "158.0" "196.8" "172.8" "163.9" "" "" "" "" "" "" "" "" "" "" "169.3" "161.1" "155.0" "126.4" "133.3" "181.7" "134.0" "142.4" "116.6" "163.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072204051848657082" "False" "High" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "0.000" "False" "16.108" "13" "2" "2" "2" "226" "24.4" "6.10" "10.55" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "61" "0" "0.855" "0.793" "0.969" "0.870" "0.775" "1.029" "0.935" "0.852" "1.779" "161.7" "138.2" "128.2" "156.7" "140.6" "125.2" "166.4" "151.1" "137.7" "287.6" "" "" "" "" "" "" "" "" "" "" "145.9" "106.6" "99.2" "105.5" "117.3" "106.9" "141.1" "109.4" "92.8" "287.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5199956621996248182" "False" "High" "IsMasterProtein" "P18859" "ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1" "0.000" "False" "16.103" "18" "1" "4" "1" "108" "12.6" "9.52" "15.74" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05511" "522" "ENSG00000154723" "ATP5PF" "hsa:522; J3KQ83; P18859" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "5" "0" "0.944" "0.966" "0.965" "1.025" "0.858" "0.802" "0.989" "0.955" "0.594" "76.7" "72.5" "74.1" "74.0" "78.7" "65.8" "61.5" "75.9" "73.3" "45.6" "" "" "" "" "" "" "" "" "" "" "69.3" "55.9" "57.3" "49.9" "65.6" "56.2" "52.2" "54.9" "49.4" "45.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2668424523932492370" "False" "High" "IsMasterProtein" "Q9BVQ7" "ATPase family gene 2 protein homolog B OS=Homo sapiens OX=9606 GN=AFG2B PE=1 SV=2" "0.000" "False" "16.017" "9" "4" "4" "4" "753" "80.7" "8.09" "10.60" "4" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "0.923" "0.765" "1.061" "1.009" "0.607" "1.039" "1.056" "0.691" "0.765" "133.7" "123.4" "102.3" "141.9" "134.9" "81.1" "138.9" "141.1" "92.4" "102.3" "" "" "" "" "" "" "" "" "" "" "120.7" "95.2" "79.1" "95.6" "112.6" "69.2" "117.9" "102.1" "62.3" "102.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794810011178551467" "False" "High" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "0.000" "False" "16.005" "24" "3" "4" "3" "118" "13.7" "8.79" "14.38" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Osteoclast signaling; Proximal tubule transport" "7" "0" "1.045" "1.125" "0.893" "1.035" "0.970" "1.097" "1.234" "1.013" "0.772" "905.1" "946.0" "1018.3" "808.5" "936.5" "877.7" "993.0" "1116.9" "917.1" "698.4" "" "" "" "" "" "" "" "" "" "" "817.0" "729.7" "787.6" "544.4" "781.2" "749.1" "842.4" "808.3" "618.6" "698.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5625477449042213507" "False" "High" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "0.000" "False" "15.996" "14" "4" "5" "4" "222" "24.7" "8.25" "16.58" "4" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "10" "0" "1.088" "1.082" "1.029" "0.967" "1.113" "1.033" "1.105" "1.053" "0.590" "439.0" "477.4" "475.2" "451.9" "424.5" "488.8" "453.7" "485.1" "462.2" "258.9" "" "" "" "" "" "" "" "" "" "" "396.3" "368.3" "367.5" "304.3" "354.1" "417.2" "384.9" "351.1" "311.7" "258.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4031307080017597315" "False" "High" "IsMasterProtein" "P18077" "Large ribosomal subunit protein eL33 OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2" "0.000" "False" "15.993" "27" "4" "8" "4" "110" "12.5" "11.06" "24.43" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01247" "6165" "ENSG00000182899" "RPL35A" "hsa:6165; P18077; Q08ES9; Q9BVN7" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.924" "1.167" "0.843" "0.955" "1.081" "0.993" "1.042" "1.005" "0.246" "524.9" "485.1" "612.3" "442.6" "501.3" "567.5" "521.5" "546.9" "527.7" "129.1" "" "" "" "" "" "" "" "" "" "" "473.8" "374.2" "473.6" "298.1" "418.1" "484.4" "442.3" "395.8" "355.9" "129.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260293505055803748" "False" "High" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "0.000" "False" "15.969" "2" "3" "3" "3" "2229" "242.8" "8.34" "11.18" "3" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "1.218" "1.398" "1.064" "1.315" "1.389" "1.234" "1.026" "1.269" "1.216" "54.0" "65.8" "75.6" "57.5" "71.0" "75.0" "66.7" "55.5" "68.6" "65.7" "" "" "" "" "" "" "" "" "" "" "48.8" "50.8" "58.4" "38.7" "59.3" "64.0" "56.5" "40.1" "46.2" "65.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607454407969117171" "False" "High" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "0.000" "False" "15.964" "10" "3" "3" "3" "376" "40.1" "5.27" "12.12" "3" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "Protein hydroxylation" "" "1" "0" "1.019" "0.912" "1.050" "1.006" "0.868" "0.979" "0.974" "0.931" "0.876" "208.9" "212.8" "190.5" "219.4" "210.0" "181.2" "204.4" "203.4" "194.4" "182.9" "" "" "" "" "" "" "" "" "" "" "188.5" "164.1" "147.3" "147.7" "175.2" "154.7" "173.4" "147.2" "131.1" "182.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2783720911668015522" "False" "High" "IsMasterProtein" "Q9NWT6" "Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2" "0.000" "False" "15.956" "12" "4" "4" "4" "349" "40.3" "5.57" "11.52" "4" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13621" "55662" "ENSG00000166135" "HIF1AN" "D3DR69; hsa:55662; Q5W147; Q969Q7; Q9NPV5; Q9NWT6" "Cellular response to hypoxia" "MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling" "3" "0" "0.858" "0.867" "0.886" "0.918" "0.882" "0.916" "0.913" "1.120" "0.968" "44.5" "38.2" "38.6" "39.4" "40.8" "39.3" "40.7" "40.6" "49.8" "43.1" "" "" "" "" "" "" "" "" "" "" "40.2" "29.5" "29.9" "26.5" "34.1" "33.5" "34.6" "29.4" "33.6" "43.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-437633753378296153" "False" "High" "IsMasterProtein" "Q9UKI8" "Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2" "0.000" "False" "15.951" "6" "5" "6" "2" "766" "86.6" "8.72" "18.70" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "9874" "ENSG00000198586" "TLK1" "B3KR15; B4DX87; hsa:9874; Q14150; Q8N591; Q9NYH2; Q9UKI8; Q9Y4F6" "" "miRNA regulation of DNA damage response; Pathways affected in adenoid cystic carcinoma; DNA damage response" "3" "0" "1.107" "0.926" "1.245" "1.066" "0.903" "1.009" "1.042" "0.960" "1.005" "157.4" "174.3" "145.8" "195.9" "167.7" "142.2" "158.8" "163.9" "151.0" "158.1" "" "" "" "" "" "" "" "" "" "" "142.0" "134.4" "112.7" "131.9" "139.9" "121.3" "134.7" "118.6" "101.8" "158.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544092344489090561" "False" "High" "IsMasterProtein" "Q8TB72" "Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2" "0.000" "False" "15.947" "5" "6" "6" "6" "1066" "114.1" "7.08" "14.38" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "23369" "ENSG00000055917" "PUM2" "B3KSL0; B4E2B6; D6W527; hsa:23369; O00234; Q53TV7; Q8TB72; Q8WY43; Q9HAN2" "Neddylation" "Male infertility" "2" "0" "0.998" "0.989" "1.114" "0.965" "0.923" "1.106" "1.025" "0.859" "0.804" "345.6" "344.9" "341.7" "385.1" "333.6" "319.1" "382.4" "354.3" "296.8" "277.9" "" "" "" "" "" "" "" "" "" "" "312.0" "266.0" "264.3" "259.3" "278.3" "272.3" "324.4" "256.4" "200.2" "277.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595519607435168922" "False" "High" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "0.000" "False" "15.945" "8" "2" "3" "2" "346" "36.9" "6.87" "10.95" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "1.091" "1.581" "1.051" "0.956" "1.516" "0.905" "0.671" "1.900" "5.715" "24.0" "26.2" "37.9" "25.2" "22.9" "36.4" "21.7" "16.1" "45.6" "137.0" "" "" "" "" "" "" "" "" "" "" "21.6" "20.2" "29.3" "17.0" "19.1" "31.0" "18.4" "11.6" "30.7" "137.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6056072514061180880" "False" "High" "IsMasterProtein" "Q9Y2D5" "PALM2-AKAP2 fusion protein OS=Homo sapiens OX=9606 GN=PALM2AKAP2 PE=1 SV=4" "0.000" "False" "15.940" "3" "2" "3" "2" "1103" "122.0" "5.06" "13.21" "2" "" "plasma membrane;other membranes" "" "Pf03285, Pf15304" "445815" "ENSG00000157654" "PALM2AKAP2" "A9Z1X9; B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; hsa:445815; Q8IXS6; Q8N9D5; Q96DU1; Q9UG26; Q9Y2D5" "" "" "0" "0" "0.815" "0.925" "1.138" "0.835" "0.962" "0.876" "0.751" "1.018" "0.638" "57.8" "47.1" "53.4" "65.7" "48.2" "55.5" "50.6" "43.4" "58.8" "36.9" "" "" "" "" "" "" "" "" "" "" "52.1" "36.3" "41.3" "44.3" "40.2" "47.4" "42.9" "31.4" "39.6" "36.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7811403610276720073" "False" "High" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "0.000" "False" "15.916" "7" "4" "4" "4" "621" "72.0" "8.70" "14.42" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "0.913" "1.082" "1.063" "0.883" "1.065" "0.881" "0.737" "1.166" "2.611" "256.0" "233.6" "277.0" "272.2" "226.1" "272.6" "225.4" "188.5" "298.5" "668.4" "" "" "" "" "" "" "" "" "" "" "231.1" "180.2" "214.2" "183.3" "188.6" "232.7" "191.2" "136.4" "201.3" "668.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625852785660981987" "False" "High" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "0.000" "False" "15.893" "19" "4" "4" "4" "192" "22.0" "5.73" "12.59" "4" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "Q15126; Q5TZW9" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "8" "0" "1.093" "0.941" "0.976" "1.090" "1.001" "1.029" "0.591" "0.943" "6.878" "288.2" "315.1" "271.1" "281.4" "314.1" "288.4" "296.5" "170.2" "271.7" "1982.3" "" "" "" "" "" "" "" "" "" "" "260.1" "243.1" "209.7" "189.5" "262.0" "246.1" "251.5" "123.2" "183.2" "1982.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494037614751494800" "False" "High" "IsMasterProtein" "O94900" "Thymocyte selection-associated high mobility group box protein TOX OS=Homo sapiens OX=9606 GN=TOX PE=1 SV=3" "0.000" "False" "15.888" "8" "4" "4" "4" "526" "57.5" "7.33" "14.73" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00505" "9760" "ENSG00000198846" "TOX" "hsa:9760; O94900; Q96AV5" "" "Mesodermal commitment pathway; Development and heterogeneity of the ILC family; Orexin receptor pathway" "3" "0" "0.917" "0.935" "1.175" "0.952" "0.849" "0.974" "1.140" "0.908" "0.865" "317.4" "291.0" "296.9" "372.9" "302.1" "269.6" "309.2" "362.0" "288.3" "274.5" "" "" "" "" "" "" "" "" "" "" "286.5" "224.5" "229.6" "251.1" "252.0" "230.1" "262.3" "262.0" "194.4" "274.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2621085061721332365" "False" "High" "IsMasterProtein" "P48382" "DNA-binding protein RFX5 OS=Homo sapiens OX=9606 GN=RFX5 PE=1 SV=1" "0.000" "False" "15.861" "6" "4" "4" "4" "616" "65.3" "9.29" "12.21" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf14621, Pf18326" "5993" "ENSG00000143390" "RFX5" "B7Z848; D3DV19; E9PFU4; hsa:5993; P48382; Q5VWC3" "" "Prion disease pathway; IL-18 signaling pathway" "2" "0" "1.062" "1.021" "1.082" "1.030" "0.929" "1.069" "1.082" "0.977" "1.029" "467.4" "496.4" "477.3" "505.9" "481.5" "434.3" "499.9" "506.0" "456.8" "481.2" "" "" "" "" "" "" "" "" "" "" "422.0" "382.9" "369.2" "340.7" "401.6" "370.7" "424.1" "366.2" "308.1" "481.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-255680334974208161" "False" "High" "IsMasterProtein" "Q9Y4K4" "Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=3" "0.000" "False" "15.850" "5" "4" "4" "4" "846" "95.0" "7.72" "11.57" "4" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00069, Pf00780" "11183" "ENSG00000012983" "MAP4K5" "A0A804HIS2; hsa:11183" "" "Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Insulin signaling" "3" "0" "0.919" "0.850" "0.941" "0.965" "0.892" "0.861" "0.979" "0.794" "1.028" "93.7" "86.1" "79.7" "88.1" "90.4" "83.6" "80.7" "91.7" "74.4" "96.4" "" "" "" "" "" "" "" "" "" "" "84.6" "66.4" "61.6" "59.4" "75.4" "71.3" "68.5" "66.4" "50.2" "96.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5356440792729817096" "False" "High" "IsMasterProtein" "Q5VZ89" "DENN domain-containing protein 4C OS=Homo sapiens OX=9606 GN=DENND4C PE=1 SV=3" "0.000" "False" "15.847" "2" "5" "5" "5" "1909" "212.6" "6.83" "14.70" "5" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "55667" "ENSG00000137145" "DENND4C" "A2A3R1; A2A3R2; A2A3R3; A2A3R9; hsa:55667; Q5VZ89; Q6AI48; Q6ZUB3; Q8NCY7; Q9H6N4; Q9NUT1; Q9NWA5; Q9NWT3; R4GN35; R4GNB2" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.981" "0.880" "0.987" "0.970" "0.840" "0.892" "0.880" "0.882" "1.842" "247.0" "242.4" "217.4" "243.7" "239.7" "207.5" "220.3" "217.3" "217.9" "455.0" "" "" "" "" "" "" "" "" "" "" "223.0" "187.0" "168.1" "164.1" "199.9" "177.1" "186.9" "157.3" "146.9" "455.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3764850706603646464" "False" "High" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "0.000" "False" "15.833" "15" "3" "8" "3" "181" "20.5" "8.82" "25.98" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "0" "0.989" "1.091" "0.746" "0.878" "1.035" "0.973" "0.988" "1.058" "0.827" "451.3" "446.3" "492.5" "336.7" "396.1" "467.2" "439.2" "445.7" "477.7" "373.3" "" "" "" "" "" "" "" "" "" "" "407.4" "344.3" "380.9" "226.8" "330.4" "398.8" "372.5" "322.5" "322.2" "373.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7173448255119182363" "False" "High" "IsMasterProtein" "P27635" "Large ribosomal subunit protein uL16 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=5" "0.000" "False" "15.783" "18" "4" "9" "4" "214" "24.6" "10.08" "23.52" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "6134" "ENSG00000147403" "RPL10" "A3KQT0; D3DWW6; hsa:6134; P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination" "Cytoplasmic ribosomal proteins; Primary ovarian insufficiency" "15" "0" "0.931" "0.994" "0.967" "1.027" "0.993" "0.982" "1.049" "0.982" "0.599" "622.4" "579.2" "618.6" "601.8" "639.4" "618.3" "611.4" "652.6" "611.1" "372.8" "" "" "" "" "" "" "" "" "" "" "561.8" "446.8" "478.4" "405.3" "533.3" "527.7" "518.6" "472.2" "412.1" "372.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594177095458516104" "False" "High" "IsMasterProtein" "P24386" "Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens OX=9606 GN=CHM PE=1 SV=3" "0.000" "False" "15.772" "7" "5" "5" "3" "653" "73.4" "4.75" "15.02" "5" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1121" "ENSG00000188419" "CHM" "A1L4D2; hsa:1121; O43732; P24386" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "" "3" "0" "0.960" "0.848" "1.073" "0.911" "0.986" "0.980" "0.958" "1.057" "0.886" "129.8" "124.6" "110.0" "139.3" "118.2" "128.0" "127.2" "124.3" "137.1" "115.0" "" "" "" "" "" "" "" "" "" "" "117.2" "96.1" "85.1" "93.8" "98.6" "109.3" "107.9" "90.0" "92.5" "115.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7404612744659791932" "False" "High" "IsMasterProtein" "Q01658" "Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1" "0.000" "False" "15.762" "16" "3" "6" "3" "176" "19.4" "4.75" "21.45" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "1810" "ENSG00000117505" "DR1" "hsa:1810; Q01658" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "1.115" "0.966" "1.008" "0.947" "1.004" "0.880" "1.039" "1.056" "0.781" "355.1" "395.8" "343.1" "358.0" "336.1" "356.6" "312.6" "368.9" "374.9" "277.4" "" "" "" "" "" "" "" "" "" "" "320.5" "305.3" "265.4" "241.1" "280.3" "304.4" "265.2" "266.9" "252.9" "277.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6425786624467733847" "False" "High" "IsMasterProtein" "O95758" "Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2" "0.000" "False" "15.756" "5" "3" "7" "1" "552" "59.7" "9.04" "26.10" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11835, Pf13893" "9991" "ENSG00000119314" "PTBP3" "B1ALY2; B1ALY3; B1ALY5; B1ALY6; B3KME7; hsa:9991; O95758; Q68DB9; Q86YB3; Q86YH9" "" "" "0" "0" "0.885" "0.813" "0.963" "0.769" "0.818" "0.826" "0.403" "0.893" "9.062" "132.9" "117.6" "108.0" "128.1" "102.2" "108.8" "109.8" "53.6" "118.7" "1204.6" "" "" "" "" "" "" "" "" "" "" "120.0" "90.7" "83.5" "86.2" "85.3" "92.8" "93.2" "38.8" "80.1" "1204.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8229141518412539790" "False" "High" "IsMasterProtein" "P68036" "Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1" "0.000" "False" "15.748" "18" "4" "13" "4" "154" "17.9" "8.51" "40.96" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7332" "ENSG00000185651" "UBE2L3" "B2R4A7; B4DDG1; B4DSZ4; E7EWS7; hsa:7332; P51966; P68036; P70653; Q9HAV1" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of necroptotic cell death; Regulation of TNFR1 signaling" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "7" "0" "0.968" "0.933" "0.877" "0.902" "0.942" "0.927" "1.048" "0.898" "0.580" "1336.9" "1294.3" "1247.7" "1172.3" "1206.4" "1258.9" "1239.3" "1400.6" "1200.6" "775.0" "" "" "" "" "" "" "" "" "" "" "1206.8" "998.3" "965.0" "789.4" "1006.3" "1074.5" "1051.3" "1013.6" "809.8" "775.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7491273576453503015" "False" "High" "IsMasterProtein" "Q9BYN0" "Sulfiredoxin-1 OS=Homo sapiens OX=9606 GN=SRXN1 PE=1 SV=2" "0.000" "False" "15.744" "30" "3" "4" "3" "137" "14.3" "8.19" "14.42" "3" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "" "140809" "ENSG00000271303" "SRXN1" "B2R543; hsa:140809; Q8NDM3; Q96AK6; Q9BYN0" "NFE2L2 regulating anti-oxidant/detoxification enzymes" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "4" "0" "1.072" "1.051" "1.216" "1.202" "1.008" "1.155" "1.051" "1.326" "1.490" "80.4" "86.1" "84.5" "97.7" "96.6" "81.0" "92.8" "84.5" "106.5" "119.8" "" "" "" "" "" "" "" "" "" "" "72.5" "66.4" "65.3" "65.8" "80.6" "69.1" "78.7" "61.1" "71.9" "119.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3875322263221301035" "False" "High" "IsMasterProtein" "P51553" "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" "0.000" "False" "15.710" "15" "6" "7" "6" "393" "42.8" "8.50" "23.14" "6" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00180" "3421" "ENSG00000067829" "IDH3G" "E9PDD5; hsa:3421; P51553; Q9BUU5" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "TCA cycle (aka Krebs or citric acid cycle)" "3" "0" "1.034" "1.038" "0.958" "1.054" "1.081" "1.021" "1.045" "1.058" "0.701" "767.1" "792.9" "796.4" "734.8" "808.3" "828.9" "783.3" "801.5" "811.2" "538.0" "" "" "" "" "" "" "" "" "" "" "692.4" "611.6" "616.0" "494.8" "674.2" "707.5" "664.4" "580.1" "547.1" "538.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4344816618369671433" "False" "High" "IsMasterProtein" "Q16537" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1" "0.000" "False" "15.690" "8" "4" "5" "3" "467" "54.7" "6.95" "14.89" "4" "signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5529" "ENSG00000154001" "PPP2R5E" "A4FU37; B7ZAW5; B7ZKK8; B7ZKK9; hsa:5529; J3KQN6; Q16537; Q52LW4" "RHO GTPases Activate Formins; RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "28" "0" "0.986" "1.269" "0.844" "1.088" "0.995" "1.082" "1.173" "1.181" "1.061" "147.1" "145.0" "186.6" "124.1" "160.0" "146.3" "159.1" "172.5" "173.7" "156.0" "" "" "" "" "" "" "" "" "" "" "132.7" "111.9" "144.4" "83.6" "133.4" "124.9" "134.9" "124.8" "117.1" "156.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049018417817342026" "False" "High" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "0.000" "False" "15.671" "22" "6" "8" "6" "229" "25.2" "4.64" "25.45" "6" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation" "11" "0" "1.052" "1.066" "1.010" "1.000" "1.044" "1.029" "1.142" "1.147" "0.697" "600.0" "631.2" "639.9" "605.7" "599.8" "626.6" "617.2" "685.0" "688.4" "418.3" "" "" "" "" "" "" "" "" "" "" "541.6" "486.9" "494.9" "407.9" "500.3" "534.8" "523.6" "495.7" "464.3" "418.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370565265455321105" "False" "High" "IsMasterProtein" "Q8IU81" "Interferon regulatory factor 2-binding protein 1 OS=Homo sapiens OX=9606 GN=IRF2BP1 PE=1 SV=1" "0.000" "False" "15.670" "5" "3" "4" "3" "584" "61.6" "8.18" "13.11" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11261" "26145" "ENSG00000170604" "IRF2BP1" "Q53EL7; Q6DC95; Q8IU81; Q9BRZ9; Q9Y4P4" "" "" "0" "0" "1.024" "1.029" "1.023" "0.966" "1.141" "1.048" "0.761" "1.109" "3.944" "263.4" "269.6" "271.1" "269.3" "254.5" "300.5" "276.0" "200.3" "292.0" "1038.8" "" "" "" "" "" "" "" "" "" "" "237.8" "208.0" "209.7" "181.4" "212.3" "256.5" "234.2" "145.0" "197.0" "1038.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "469142345215753577" "False" "High" "IsMasterProtein" "Q9Y2R9" "Small ribosomal subunit protein uS7m OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" "0.000" "False" "15.660" "10" "2" "4" "2" "242" "28.1" "9.99" "14.54" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00177" "51081" "ENSG00000125445" "MRPS7" "B2R9N5; hsa:51081; Q53GD6; Q9Y2R9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.032" "0.842" "1.147" "1.076" "0.917" "1.200" "0.977" "0.971" "1.237" "87.8" "90.6" "73.9" "100.7" "94.5" "80.5" "105.3" "85.7" "85.2" "108.5" "" "" "" "" "" "" "" "" "" "" "79.2" "69.9" "57.2" "67.8" "78.8" "68.7" "89.3" "62.1" "57.5" "108.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302543892740036521" "False" "High" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "0.000" "False" "15.629" "8" "2" "3" "2" "282" "31.5" "4.55" "11.53" "2" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "1.008" "1.207" "1.023" "0.986" "1.070" "0.931" "1.321" "1.120" "0.597" "146.1" "147.2" "176.3" "149.4" "144.0" "156.3" "136.0" "192.9" "163.7" "87.3" "" "" "" "" "" "" "" "" "" "" "131.9" "113.5" "136.4" "100.6" "120.1" "133.4" "115.4" "139.6" "110.4" "87.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5085231935458707065" "False" "High" "IsMasterProtein" "O75530" "Polycomb protein EED OS=Homo sapiens OX=9606 GN=EED PE=1 SV=2" "0.000" "False" "15.607" "12" "5" "6" "5" "441" "50.2" "7.03" "15.52" "5" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "8726" "ENSG00000074266" "EED" "A8K7V5; hsa:8726; O00149; O75530; Q6NTH2; Q7LDA5; Q7LDG8; Q86VV2; Q9UNY7" "HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; 5q35 copy number variation" "15" "0" "1.054" "1.033" "1.102" "0.989" "0.983" "0.929" "1.053" "1.067" "1.480" "181.0" "190.8" "186.9" "199.5" "179.1" "177.9" "168.1" "190.5" "193.2" "267.8" "" "" "" "" "" "" "" "" "" "" "163.4" "147.2" "144.5" "134.3" "149.4" "151.8" "142.6" "137.9" "130.3" "267.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6638571290352112575" "False" "High" "IsMasterProtein" "O00746" "Nucleoside diphosphate kinase, mitochondrial OS=Homo sapiens OX=9606 GN=NME4 PE=1 SV=1" "0.000" "False" "15.602" "26" "3" "5" "3" "187" "20.6" "10.29" "17.16" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00334" "4833" "ENSG00000103202" "NME4" "A2IDD0; hsa:4833; O00746; Q5U0M9" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "1.139" "1.232" "1.160" "1.080" "1.181" "1.112" "0.962" "1.389" "1.353" "59.4" "67.7" "73.2" "68.9" "64.2" "70.1" "66.1" "57.2" "82.5" "80.4" "" "" "" "" "" "" "" "" "" "" "53.6" "52.2" "56.6" "46.4" "53.5" "59.9" "56.0" "41.4" "55.6" "80.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7558389581764573434" "False" "High" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "0.000" "False" "15.596" "5" "3" "5" "3" "919" "101.7" "5.62" "15.80" "3" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "14" "0" "0.790" "0.862" "1.013" "0.920" "0.861" "1.082" "0.839" "0.874" "3.199" "137.6" "108.7" "118.6" "139.4" "126.6" "118.4" "148.8" "115.4" "120.3" "440.0" "" "" "" "" "" "" "" "" "" "" "124.2" "83.8" "91.7" "93.9" "105.6" "101.1" "126.2" "83.5" "81.1" "440.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441790046039018783" "False" "High" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "0.000" "False" "15.578" "20" "5" "7" "5" "213" "23.9" "8.76" "20.81" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "Pyroptosis; Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Late endosomal microautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "1.022" "0.964" "0.988" "1.006" "0.893" "1.015" "1.113" "0.936" "0.772" "458.0" "468.0" "441.6" "452.6" "460.8" "408.9" "464.7" "509.7" "428.5" "353.4" "" "" "" "" "" "" "" "" "" "" "413.4" "361.0" "341.6" "304.8" "384.4" "349.0" "394.2" "368.9" "289.0" "353.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9137773696009286865" "False" "High" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "0.000" "False" "15.567" "22" "2" "5" "2" "118" "12.9" "5.52" "15.67" "2" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "0.900" "0.856" "1.078" "0.903" "0.824" "0.942" "0.949" "0.925" "1.259" "359.6" "323.7" "307.6" "387.8" "324.6" "296.2" "338.8" "341.2" "332.5" "452.6" "" "" "" "" "" "" "" "" "" "" "324.6" "249.7" "237.9" "261.1" "270.8" "252.8" "287.4" "246.9" "224.3" "452.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-560084501499272066" "False" "High" "IsMasterProtein" "Q8IY18" "Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2" "0.000" "False" "15.560" "3" "4" "5" "4" "1101" "128.7" "8.38" "11.72" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "23137" "ENSG00000198887" "SMC5" "A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277181117143708744" "False" "High" "IsMasterProtein" "P60866" "Small ribosomal subunit protein uS10 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "0.000" "False" "15.536" "32" "4" "6" "4" "119" "13.4" "9.94" "18.56" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.998" "1.166" "1.125" "1.104" "1.139" "1.143" "1.105" "1.076" "0.657" "309.1" "308.4" "360.6" "347.8" "341.3" "352.2" "353.3" "341.7" "332.7" "203.1" "" "" "" "" "" "" "" "" "" "" "279.1" "237.9" "278.9" "234.2" "284.7" "300.6" "299.7" "247.3" "224.4" "203.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8554271472140898461" "False" "High" "IsMasterProtein" "Q8N584" "Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=1 SV=2" "0.000" "False" "15.533" "7" "4" "5" "4" "583" "65.8" "6.99" "13.02" "4" "cell organization and biogenesis;developmental processes" "" "" "Pf10300" "125488" "ENSG00000168234" "TTC39C" "B7WP63; hsa:125488; J3QRR1; Q0VAJ2; Q8N284; Q8N584" "" "" "0" "0" "1.026" "1.013" "1.055" "1.084" "1.059" "0.949" "0.972" "1.053" "0.781" "296.3" "304.2" "300.3" "312.5" "321.3" "313.7" "281.3" "288.1" "311.9" "231.4" "" "" "" "" "" "" "" "" "" "" "267.5" "234.6" "232.3" "210.4" "268.0" "267.8" "238.6" "208.5" "210.4" "231.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1665507599286513190" "False" "High" "IsMasterProtein" "P62873" "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens OX=9606 GN=GNB1 PE=1 SV=3" "0.000" "False" "15.529" "9" "3" "4" "1" "340" "37.4" "6.00" "11.45" "3" "cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "2782" "ENSG00000078369" "GNB1" "B1AJZ7; hsa:2782; P04697; P04901; P62873; Q1RMY8" "Inactivation, recovery and regulation of the phototransduction cascade; G alpha (12/13) signalling events; Olfactory Signaling Pathway; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Sensory perception of sweet, bitter, and umami (glutamate) taste; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation; Activation of the phototransduction cascade" "Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; 1p36 copy number variation syndrome; Calcium regulation in cardiac cells; Estrogen signaling pathway" "45" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3536014580655726636" "False" "High" "IsMasterProtein" "P98170" "E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2" "0.000" "False" "15.514" "8" "4" "5" "4" "497" "56.6" "6.65" "14.32" "4" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00653, Pf13920, Pf21290" "331" "ENSG00000101966" "XIAP" "D3DTF2; hsa:331; P98170; Q9NQ14" "Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Regulation of PTEN localization" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Apoptosis; Focal adhesion; Copper homeostasis; NO/cGMP/PKG mediated neuroprotection; Complement system in neuronal development and plasticity" "20" "0" "0.969" "1.329" "1.106" "0.937" "1.191" "1.013" "0.806" "1.306" "3.287" "133.2" "129.1" "177.0" "147.3" "124.7" "158.6" "134.9" "107.3" "174.0" "437.6" "" "" "" "" "" "" "" "" "" "" "120.2" "99.6" "136.9" "99.2" "104.0" "135.4" "114.4" "77.6" "117.3" "437.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758284595644048114" "False" "High" "IsMasterProtein" "P78345" "Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2" "0.000" "False" "15.511" "13" "3" "3" "3" "283" "31.8" "9.92" "11.97" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "10557" "ENSG00000152464" "RPP38" "B3KPY0; D3DRT8; hsa:10557; P78345; Q53F71; Q8NHS8" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "Sphingolipid metabolism in senescence" "3" "0" "0.866" "0.866" "0.925" "0.891" "0.826" "0.781" "0.750" "0.859" "0.631" "210.9" "182.7" "182.6" "195.0" "187.8" "174.1" "164.6" "158.2" "181.0" "133.1" "" "" "" "" "" "" "" "" "" "" "190.3" "140.9" "141.2" "131.3" "156.7" "148.6" "139.6" "114.5" "122.1" "133.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449496976955696731" "False" "High" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "0.000" "False" "15.506" "10" "3" "3" "3" "308" "33.9" "4.84" "10.85" "3" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "NoRC negatively regulates rRNA expression" "" "1" "0" "1.005" "1.006" "1.063" "0.907" "1.023" "0.971" "1.009" "0.980" "1.026" "205.1" "206.1" "206.4" "218.1" "186.0" "209.9" "199.2" "206.9" "201.0" "210.5" "" "" "" "" "" "" "" "" "" "" "185.2" "159.0" "159.6" "146.8" "155.1" "179.1" "169.0" "149.7" "135.6" "210.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4567106574901643860" "False" "High" "IsMasterProtein" "O60826" "Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1" "0.000" "False" "15.468" "6" "3" "3" "3" "627" "70.7" "6.74" "11.13" "3" "transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle" "other molecular function" "Pf05667, Pf21674" "28952" "ENSG00000101997" "CCDC22" "A8K7G1; hsa:28952; O60826" "Neddylation" "" "1" "0" "0.867" "0.792" "0.769" "0.884" "0.820" "0.850" "0.951" "0.783" "1.195" "95.4" "82.7" "75.6" "73.4" "84.4" "78.3" "81.1" "90.8" "74.7" "114.0" "" "" "" "" "" "" "" "" "" "" "86.2" "63.8" "58.5" "49.4" "70.4" "66.8" "68.8" "65.7" "50.4" "114.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449077897622524501" "False" "High" "IsMasterProtein" "O95551" "Tyrosyl-DNA phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=TDP2 PE=1 SV=1" "0.000" "False" "15.447" "10" "3" "3" "3" "362" "40.9" "5.10" "11.49" "3" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf14555" "51567" "ENSG00000111802" "TDP2" "B4DKL8; B4DQ95; O95551; Q2TBE2; Q5JYM0; Q7Z6U5; Q9NUK5; Q9NYY9" "Nonhomologous End-Joining (NHEJ)" "Oxidative damage response" "2" "0" "0.770" "0.753" "0.871" "0.893" "0.725" "0.774" "0.815" "0.861" "1.171" "114.3" "88.0" "86.1" "99.6" "102.1" "82.8" "88.4" "93.1" "98.4" "133.8" "" "" "" "" "" "" "" "" "" "" "103.2" "67.9" "66.6" "67.1" "85.1" "70.7" "75.0" "67.4" "66.3" "133.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361543221458196950" "False" "High" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "0.000" "False" "15.431" "16" "6" "7" "6" "372" "41.9" "7.31" "19.89" "6" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "GDP-fucose biosynthesis" "" "1" "0" "1.035" "0.955" "1.048" "0.962" "0.942" "1.015" "1.033" "1.018" "0.728" "458.1" "474.0" "437.7" "479.8" "440.5" "431.7" "465.0" "473.1" "466.3" "333.6" "" "" "" "" "" "" "" "" "" "" "413.5" "365.6" "338.5" "323.1" "367.5" "368.5" "394.4" "342.3" "314.5" "333.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3533447776593040930" "False" "High" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=2" "0.000" "False" "15.412" "6" "4" "8" "2" "557" "59.6" "9.16" "28.81" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "5725" "ENSG00000011304" "PTBP1" "hsa:5725; P26599; Q9BUQ0" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "mir-124 predicted interactions with cell cycle and differentiation ; mRNA processing" "5" "2" "0.950" "1.103" "0.995" "0.987" "1.019" "1.005" "0.845" "1.110" "3.639" "1130.8" "1074.7" "1246.8" "1125.2" "1115.6" "1152.8" "1136.2" "955.6" "1254.9" "4115.5" "" "" "" "" "" "" "" "" "" "" "1020.8" "828.9" "964.3" "757.7" "930.6" "984.0" "963.8" "691.5" "846.4" "4115.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4299442073717893558" "False" "High" "IsMasterProtein" "Q9Y6A4" "Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1" "0.000" "False" "15.403" "17" "3" "4" "3" "193" "22.8" "9.76" "12.31" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf05018" "29105" "ENSG00000070761" "CFAP20" "hsa:29105; Q9Y6A4" "" "" "0" "0" "0.990" "1.343" "0.973" "1.054" "1.280" "1.092" "0.946" "1.202" "1.778" "145.5" "144.1" "195.4" "141.6" "153.4" "186.3" "158.9" "137.6" "174.9" "258.7" "" "" "" "" "" "" "" "" "" "" "131.3" "111.2" "151.1" "95.4" "128.0" "159.0" "134.8" "99.6" "118.0" "258.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535429357355427418" "False" "High" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "0.000" "False" "15.381" "10" "2" "6" "2" "225" "24.3" "7.94" "17.81" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "Ciliary landscape" "3" "0" "1.013" "1.060" "1.073" "1.070" "1.044" "1.013" "1.061" "1.062" "0.947" "550.7" "557.7" "583.9" "591.1" "589.3" "575.0" "557.7" "584.4" "585.1" "521.5" "" "" "" "" "" "" "" "" "" "" "497.1" "430.2" "451.6" "398.0" "491.6" "490.8" "473.0" "422.9" "394.6" "521.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8847803836591392449" "False" "High" "IsMasterProtein" "A0AAG2SUK6" "Uncharacterized protein OS=Homo sapiens OX=9606 PE=4 SV=1" "0.000" "False" "15.379" "15" "2" "4" "2" "153" "17.8" "9.69" "11.94" "2" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.991" "0.860" "0.904" "1.026" "0.851" "0.966" "0.990" "0.857" "0.944" "193.7" "192.0" "166.5" "175.2" "198.8" "164.9" "187.1" "191.7" "166.1" "182.9" "" "" "" "" "" "" "" "" "" "" "174.9" "148.1" "128.8" "117.9" "165.8" "140.7" "158.7" "138.7" "112.0" "182.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7765133988428364561" "False" "High" "IsMasterProtein" "Q58WW2" "DDB1- and CUL4-associated factor 6 OS=Homo sapiens OX=9606 GN=DCAF6 PE=1 SV=1" "0.000" "False" "15.367" "7" "6" "6" "6" "860" "96.2" "5.27" "15.86" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55827" "ENSG00000143164" "DCAF6" "A2A295; B4DNB8; hsa:55827; Q58WW2; Q7L8I0; Q8IXH3; Q8TB19" "Neddylation" "" "1" "0" "0.937" "0.850" "0.993" "1.072" "1.023" "0.767" "0.993" "0.839" "0.858" "55.1" "51.7" "46.9" "54.8" "59.1" "56.4" "42.3" "54.8" "46.3" "47.3" "" "" "" "" "" "" "" "" "" "" "49.8" "39.8" "36.3" "36.9" "49.3" "48.1" "35.9" "39.6" "31.2" "47.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3054532643706144768" "False" "High" "IsMasterProtein" "Q9H0W9" "Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1" "0.000" "False" "15.360" "14" "4" "7" "4" "315" "35.1" "6.70" "17.81" "4" "" "nucleus" "other molecular function" "Pf08925" "28970" "ENSG00000182919" "C11orf54" "A8K850; hsa:28970; Q6FI88; Q6XYB0; Q96EI3; Q96IX1; Q9H0W9; Q9Y6B4" "" "" "0" "0" "0.898" "0.855" "1.089" "0.901" "1.009" "1.074" "0.966" "0.807" "0.699" "91.3" "81.9" "78.0" "99.4" "82.2" "92.1" "98.0" "88.2" "73.6" "63.8" "" "" "" "" "" "" "" "" "" "" "82.4" "63.2" "60.4" "66.9" "68.6" "78.6" "83.2" "63.8" "49.7" "63.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6843403857140785601" "False" "High" "IsMasterProtein" "Q8NBL1" "Protein O-glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POGLUT1 PE=1 SV=1" "0.000" "False" "15.307" "7" "3" "3" "3" "392" "46.2" "8.72" "9.61" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf05686" "56983" "ENSG00000163389" "POGLUT1" "B2RD13; hsa:56983; Q53GJ4; Q8N2T1; Q8NBL1" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "" "1" "0" "1.055" "1.107" "1.350" "1.041" "1.105" "1.063" "0.874" "1.245" "0.833" "88.2" "93.0" "97.7" "119.1" "91.9" "97.5" "93.8" "77.1" "109.9" "73.5" "" "" "" "" "" "" "" "" "" "" "79.6" "71.8" "75.5" "80.2" "76.6" "83.2" "79.5" "55.8" "74.1" "73.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2085339884306235514" "False" "High" "IsMasterProtein" "Q13501" "Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1" "0.000" "False" "15.297" "12" "3" "4" "3" "440" "47.7" "5.22" "14.81" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00564, Pf00569, Pf16577" "8878" "ENSG00000161011; ENSG00000284099" "SQSTM1" "A6NFN7; B2R661; B3KUW5; hsa:8878; Q13446; Q13501; Q9BUV7; Q9BVS6; Q9UEU1" "KEAP1-NFE2L2 pathway; Neddylation; Interleukin-1 signaling; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; Nuclear events mediated by NFE2L2; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy" "IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome; Opioid receptor pathways; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; HDAC6 interactions in the central nervous system" "24" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8429981221702182893" "False" "High" "IsMasterProtein" "P20340" "Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3" "0.000" "False" "15.296" "10" "2" "4" "1" "208" "23.6" "5.54" "12.42" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5870" "ENSG00000175582" "RAB6A" "A8K133; B7Z772; F5H668; hsa:5870; P20340; Q1W5D8; Q5U0A8; Q9UBE4" "COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; TBC/RABGAPs" "" "7" "0" "1.012" "1.451" "1.132" "1.002" "1.281" "1.010" "0.856" "1.398" "0.682" "240.4" "243.3" "349.0" "272.2" "240.8" "307.9" "242.9" "205.8" "336.2" "163.9" "" "" "" "" "" "" "" "" "" "" "217.0" "187.7" "269.9" "183.3" "200.9" "262.8" "206.0" "149.0" "226.7" "163.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697106387219567458" "False" "High" "IsMasterProtein" "Q6P2E9" "Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1" "0.000" "False" "15.293" "2" "3" "4" "3" "1401" "151.6" "5.86" "13.03" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf16529, Pf21289" "23644" "ENSG00000038358" "EDC4" "A6NGM1; A8K4T4; hsa:23644; Q13025; Q13826; Q6P2E9; Q6ZR12; Q7Z6H7" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "0.945" "0.995" "1.174" "1.143" "1.148" "0.920" "0.894" "0.996" "1.553" "212.5" "200.8" "211.3" "249.4" "242.9" "243.9" "195.6" "189.9" "211.8" "330.0" "" "" "" "" "" "" "" "" "" "" "191.8" "154.9" "163.5" "168.0" "202.6" "208.2" "165.9" "137.5" "142.8" "330.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7376822484090122143" "False" "High" "IsMasterProtein" "P05166" "Propionyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=PCCB PE=1 SV=3" "0.000" "False" "15.284" "6" "3" "4" "3" "539" "58.2" "7.64" "15.74" "3" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "5096" "ENSG00000114054" "PCCB" "B7Z2Z4; hsa:5096; P05166; Q16813; Q96CX0" "Biotin transport and metabolism; Mitochondrial protein degradation; Defective HLCS causes multiple carboxylase deficiency; Propionyl-CoA catabolism" "Primary ovarian insufficiency" "5" "0" "0.977" "1.043" "1.065" "1.059" "1.120" "1.092" "1.008" "1.132" "0.782" "324.4" "317.0" "338.2" "345.5" "343.4" "363.4" "354.2" "326.9" "367.2" "253.6" "" "" "" "" "" "" "" "" "" "" "292.8" "244.5" "261.6" "232.7" "286.5" "310.2" "300.5" "236.6" "247.7" "253.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3162421235115001887" "False" "High" "IsMasterProtein" "L0R819" "ASNSD1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=ASDURF PE=1 SV=1" "0.000" "False" "15.270" "28" "3" "4" "3" "96" "11.2" "8.88" "12.97" "3" "other biological processes" "other cell component" "" "" "" "ENSG00000286053" "ASDURF" "L0R819" "" "" "0" "0" "1.059" "1.197" "0.996" "0.984" "1.113" "0.997" "1.046" "1.089" "0.902" "188.9" "200.1" "226.1" "188.1" "185.9" "210.2" "188.4" "197.6" "205.7" "170.3" "" "" "" "" "" "" "" "" "" "" "170.5" "154.4" "174.9" "126.7" "155.1" "179.4" "159.8" "143.0" "138.7" "170.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2381350149897154971" "False" "High" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "0.000" "False" "15.268" "13" "4" "4" "4" "246" "28.0" "8.44" "13.61" "4" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; RSV-host interactions; RHOA GTPase cycle; Apoptotic cleavage of cellular proteins" "" "5" "0" "0.965" "2.263" "0.957" "1.002" "2.071" "0.976" "0.999" "2.178" "0.748" "405.7" "391.7" "918.3" "388.2" "406.6" "840.5" "395.9" "405.2" "883.8" "303.3" "" "" "" "" "" "" "" "" "" "" "366.3" "302.1" "710.2" "261.4" "339.2" "717.4" "335.8" "293.2" "596.1" "303.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599424746602695209" "False" "High" "IsMasterProtein" "Q9ULE6" "Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3" "0.000" "False" "15.245" "5" "4" "4" "4" "856" "96.7" "6.54" "13.23" "4" "" "cytosol;other cell component" "other molecular function" "Pf14566" "27143" "ENSG00000107719" "PALD1" "B2RMS1; B9EGC6; hsa:27143; Q5JTK7; Q5JTK8; Q9ULE6" "" "" "0" "0" "1.118" "0.930" "0.890" "1.051" "0.963" "0.964" "0.974" "0.894" "1.004" "208.6" "233.2" "194.0" "185.6" "219.2" "200.9" "201.1" "203.3" "186.4" "209.5" "" "" "" "" "" "" "" "" "" "" "188.3" "179.9" "150.0" "125.0" "182.9" "171.5" "170.6" "147.1" "125.8" "209.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4605522544337800066" "False" "High" "IsMasterProtein" "Q9Y3U8" "Large ribosomal subunit protein eL36 OS=Homo sapiens OX=9606 GN=RPL36 PE=1 SV=3" "0.000" "False" "15.237" "21" "3" "5" "3" "105" "12.2" "11.59" "16.67" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01158" "25873" "ENSG00000130255" "RPL36" "B2R4Y1; D6W634; hsa:25873; Q6FIG1; Q9UQF6; Q9Y3U8" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.992" "1.071" "0.808" "1.057" "1.074" "0.942" "1.134" "1.103" "0.417" "327.3" "324.6" "350.7" "264.3" "346.1" "351.6" "308.2" "371.1" "361.1" "136.6" "" "" "" "" "" "" "" "" "" "" "295.5" "250.4" "271.3" "178.0" "288.7" "300.1" "261.5" "268.6" "243.5" "136.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575582902092764945" "False" "High" "IsMasterProtein" "Q9NQA3" "WAS protein family homolog 6 OS=Homo sapiens OX=9606 GN=WASH6P PE=1 SV=3" "0.000" "False" "15.214" "7" "2" "3" "1" "447" "48.0" "5.67" "10.93" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH6P" "A6NGF1; Q8N305; Q9NQA3" "" "" "0" "0" "0.839" "1.117" "0.879" "0.872" "1.052" "1.261" "0.900" "0.925" "0.937" "59.9" "50.2" "66.9" "52.6" "52.2" "63.0" "75.5" "53.9" "55.4" "56.1" "" "" "" "" "" "" "" "" "" "" "54.1" "38.8" "51.7" "35.4" "43.6" "53.8" "64.1" "39.0" "37.4" "56.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4484612190120374131" "False" "High" "IsMasterProtein" "Q9Y6Y0" "Influenza virus NS1A-binding protein OS=Homo sapiens OX=9606 GN=IVNS1ABP PE=1 SV=3" "0.000" "False" "15.192" "9" "6" "6" "6" "642" "71.7" "5.53" "14.73" "6" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707" "10625" "ENSG00000116679" "IVNS1ABP" "A8K8R6; hsa:10625; Q1G4T6; Q1G4T7; Q5TF75; Q6NW38; Q7LCG2; Q9NZX0; Q9Y480; Q9Y6Y0" "" "" "0" "0" "0.981" "0.913" "0.986" "0.899" "0.953" "0.896" "0.793" "0.953" "2.230" "442.0" "433.4" "403.6" "435.6" "397.5" "421.2" "396.2" "350.5" "421.3" "985.5" "" "" "" "" "" "" "" "" "" "" "399.0" "334.3" "312.2" "293.3" "331.6" "359.5" "336.1" "253.6" "284.2" "985.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "765579875042607640" "False" "High" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "0.000" "False" "15.180" "25" "2" "18" "2" "81" "9.1" "8.43" "50.42" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "UCH proteinases; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Iron uptake and transport; TGF-beta receptor signaling activates SMADs" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "7" "0" "0.995" "1.049" "1.010" "0.971" "0.996" "1.022" "1.074" "1.018" "0.801" "1238.0" "1232.4" "1298.6" "1250.7" "1201.5" "1233.0" "1265.7" "1330.0" "1260.7" "992.2" "" "" "" "" "" "" "" "" "" "" "1117.5" "950.6" "1004.4" "842.2" "1002.3" "1052.3" "1073.7" "962.5" "850.3" "992.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7687733002656654502" "False" "High" "IsMasterProtein" "P18031" "Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1" "0.000" "False" "15.155" "10" "5" "5" "5" "435" "49.9" "6.27" "16.19" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5770" "ENSG00000196396" "PTPN1" "hsa:5770; P18031; Q5TGD8; Q9BQV9; Q9NQQ4" "Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Negative regulation of MET activity; Insulin receptor recycling; Integrin signaling; MECP2 regulates neuronal receptors and channels; PTK6 Down-Regulation" "Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "14" "0" "0.976" "1.067" "0.937" "1.077" "0.935" "0.992" "0.835" "1.058" "7.764" "119.3" "116.5" "127.3" "111.8" "128.5" "111.5" "118.3" "99.6" "126.2" "926.1" "" "" "" "" "" "" "" "" "" "" "107.7" "89.8" "98.5" "75.3" "107.2" "95.2" "100.4" "72.1" "85.1" "926.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9195295084740601325" "False" "High" "IsMasterProtein" "Q00577" "Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2" "0.000" "False" "15.137" "16" "4" "5" "4" "322" "34.9" "6.44" "15.70" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04845" "5813" "ENSG00000185129" "PURA" "hsa:5813; Q00577" "" "Exercise-induced circadian regulation" "1" "0" "1.006" "0.976" "0.922" "1.025" "1.093" "1.028" "0.912" "1.028" "0.858" "410.5" "413.1" "400.6" "378.6" "420.8" "448.6" "421.9" "374.5" "422.1" "352.4" "" "" "" "" "" "" "" "" "" "" "370.6" "318.7" "309.8" "255.0" "351.0" "382.9" "357.9" "271.0" "284.7" "352.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1727135258656817627" "False" "High" "IsMasterProtein" "Q9BTL3" "RNA guanine-N7 methyltransferase activating subunit OS=Homo sapiens OX=9606 GN=RAMAC PE=1 SV=1" "0.000" "False" "15.134" "41" "5" "5" "5" "118" "14.4" "8.94" "17.04" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15320" "83640" "ENSG00000169612" "RAMAC" "hsa:83640; Q2M1J8; Q9BTL3" "" "15q25 copy number variation" "1" "0" "0.958" "1.006" "0.848" "0.930" "1.036" "0.942" "1.032" "1.013" "0.806" "419.1" "401.5" "421.5" "355.6" "389.6" "434.3" "394.8" "432.3" "424.3" "338.0" "" "" "" "" "" "" "" "" "" "" "378.3" "309.7" "326.0" "239.5" "325.0" "370.7" "334.9" "312.8" "286.2" "338.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2201882454177381815" "False" "High" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "0.000" "False" "15.080" "21" "3" "9" "3" "154" "16.8" "5.24" "24.36" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287, Pf21485" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Hypusine synthesis from eIF5A-lysine" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "3" "0" "0.976" "0.967" "0.903" "0.919" "0.909" "0.923" "1.007" "0.998" "1.710" "713.4" "696.1" "689.9" "644.4" "655.6" "648.6" "658.1" "718.4" "711.6" "1220.2" "" "" "" "" "" "" "" "" "" "" "643.9" "537.0" "533.6" "433.9" "546.9" "553.6" "558.2" "519.9" "479.9" "1220.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7016247097338811422" "False" "High" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "0.000" "False" "15.062" "11" "4" "5" "4" "420" "46.9" "8.54" "13.33" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf21369" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "mRNA Splicing - Major Pathway" "" "1" "0" "1.002" "0.952" "1.006" "0.967" "0.926" "0.942" "1.010" "0.922" "0.981" "381.7" "382.5" "363.4" "384.1" "369.1" "353.4" "359.6" "385.7" "352.1" "374.4" "" "" "" "" "" "" "" "" "" "" "344.6" "295.0" "281.1" "258.6" "307.9" "301.7" "305.1" "279.1" "237.5" "374.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9099132526023132947" "False" "High" "IsMasterProtein" "Q9Y6D5" "Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3" "0.000" "False" "15.045" "3" "6" "6" "4" "1785" "201.9" "6.33" "14.90" "6" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10564" "ENSG00000124198" "ARFGEF2" "hsa:10564; Q5TFT9; Q9NTS1; Q9Y6D5" "Association of TriC/CCT with target proteins during biosynthesis" "" "1" "0" "1.094" "1.008" "0.890" "1.123" "1.054" "1.263" "1.113" "1.111" "1.917" "81.3" "88.9" "81.9" "72.4" "91.3" "85.7" "102.7" "90.5" "90.3" "155.9" "" "" "" "" "" "" "" "" "" "" "73.4" "68.6" "63.4" "48.7" "76.1" "73.1" "87.1" "65.5" "60.9" "155.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4853611610042411436" "False" "High" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "0.000" "False" "15.041" "18" "5" "12" "5" "184" "20.8" "5.31" "29.03" "5" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "Pyruvate metabolism" "" "1" "0" "0.989" "1.061" "0.939" "1.017" "1.053" "0.941" "1.056" "1.024" "0.688" "648.4" "641.2" "687.7" "609.0" "659.3" "682.6" "610.2" "684.5" "663.8" "446.3" "" "" "" "" "" "" "" "" "" "" "585.3" "494.6" "531.9" "410.1" "550.0" "582.6" "517.6" "495.4" "447.7" "446.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849242953917426165" "False" "High" "IsMasterProtein" "Q9HCD5" "Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2" "0.000" "False" "15.035" "9" "6" "8" "6" "579" "65.5" "9.60" "24.86" "6" "signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "" "57727" "ENSG00000124160" "NCOA5" "B2RTV9; E1P5R0; Q6HA99; Q9H1F2; Q9H2T2; Q9H4Y9; Q9HCD5" "" "" "0" "0" "0.955" "1.460" "0.956" "0.988" "1.257" "0.955" "0.947" "1.479" "1.572" "618.4" "590.8" "902.8" "591.3" "611.2" "777.1" "590.7" "585.6" "914.4" "972.2" "" "" "" "" "" "" "" "" "" "" "558.2" "455.7" "698.3" "398.2" "509.8" "663.3" "501.1" "423.8" "616.8" "972.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-849081801659546262" "False" "High" "IsMasterProtein" "P30533" "Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1" "0.000" "False" "15.031" "9" "3" "4" "3" "357" "41.4" "8.78" "10.13" "3" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06400, Pf06401" "4043" "ENSG00000163956" "LRPAP1" "D3DVR9; hsa:4043; P30533; Q2M310; Q53HQ3; Q53HS6" "" "Cholesterol metabolism" "1" "0" "0.948" "0.998" "0.916" "1.010" "0.991" "0.962" "1.205" "0.941" "0.801" "154.1" "146.1" "153.7" "141.2" "155.6" "152.6" "148.3" "185.6" "145.0" "123.5" "" "" "" "" "" "" "" "" "" "" "139.1" "112.7" "118.9" "95.1" "129.8" "130.3" "125.8" "134.3" "97.8" "123.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "222321955828462706" "False" "High" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "0.000" "False" "15.022" "50" "3" "6" "3" "68" "7.4" "7.24" "21.43" "3" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "Copper homeostasis" "3" "0" "0.961" "1.046" "1.046" "1.010" "1.043" "0.967" "1.202" "1.145" "0.745" "466.6" "448.3" "488.0" "488.1" "471.4" "486.9" "451.4" "560.8" "534.3" "347.5" "" "" "" "" "" "" "" "" "" "" "421.2" "345.8" "377.5" "328.7" "393.2" "415.5" "382.9" "405.8" "360.4" "347.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265990204774033592" "False" "High" "IsMasterProtein" "O75175" "CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1" "0.000" "False" "15.018" "5" "3" "4" "3" "753" "81.8" "6.20" "9.98" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04065, Pf04153" "4849" "ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615" "CNOT3" "hsa:4849; O75175; Q9NZN7; Q9UF76" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "1.062" "1.323" "1.098" "1.049" "1.307" "1.096" "1.045" "1.388" "1.449" "184.3" "195.7" "243.7" "202.3" "193.4" "240.8" "202.0" "192.5" "255.7" "267.1" "" "" "" "" "" "" "" "" "" "" "166.3" "150.9" "188.5" "136.3" "161.3" "205.6" "171.4" "139.3" "172.5" "267.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2588985702309620212" "False" "High" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "0.000" "False" "15.007" "13" "4" "5" "4" "299" "33.4" "5.25" "15.53" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "0.973" "0.820" "1.036" "0.972" "0.917" "0.965" "0.811" "1.010" "1.920" "165.9" "161.5" "136.0" "171.9" "161.2" "152.1" "160.1" "134.5" "167.5" "318.6" "" "" "" "" "" "" "" "" "" "" "149.8" "124.5" "105.2" "115.7" "134.5" "129.8" "135.8" "97.4" "113.0" "318.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6167412320153067815" "False" "High" "IsMasterProtein" "P35613" "Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2" "0.000" "False" "14.999" "9" "3" "4" "3" "385" "42.2" "5.66" "8.89" "3" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13927" "682" "ENSG00000172270" "BSG" "A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7" "Proton-coupled monocarboxylate transport; Integrin cell surface interactions; Degradation of the extracellular matrix; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "10" "0" "0.987" "0.892" "1.026" "0.925" "0.925" "0.952" "1.062" "0.931" "0.577" "294.5" "290.8" "262.8" "302.0" "272.3" "272.3" "280.3" "312.8" "274.2" "169.8" "" "" "" "" "" "" "" "" "" "" "265.8" "224.3" "203.2" "203.4" "227.1" "232.4" "237.7" "226.4" "184.9" "169.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-309007205683403427" "False" "High" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "0.000" "False" "14.993" "12" "4" "5" "4" "365" "41.3" "8.68" "10.90" "4" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "" "Mesodermal commitment pathway" "1" "0" "1.009" "1.231" "0.990" "0.993" "1.180" "0.932" "0.827" "1.142" "1.313" "159.5" "160.9" "196.2" "157.9" "158.4" "188.2" "148.7" "131.9" "182.1" "209.4" "" "" "" "" "" "" "" "" "" "" "143.9" "124.1" "151.8" "106.3" "132.1" "160.6" "126.1" "95.5" "122.8" "209.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1008427851520544832" "False" "High" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "0.000" "False" "14.971" "3" "3" "4" "3" "808" "87.1" "9.19" "11.99" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "TBC/RABGAPs" "" "1" "0" "0.799" "1.443" "1.109" "1.068" "1.396" "0.924" "1.140" "1.425" "1.024" "79.7" "63.7" "115.0" "88.4" "85.1" "111.3" "73.7" "90.8" "113.6" "81.6" "" "" "" "" "" "" "" "" "" "" "71.9" "49.1" "88.9" "59.5" "71.0" "95.0" "62.5" "65.7" "76.6" "81.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8898508644132712333" "False" "High" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "0.000" "False" "14.967" "23" "5" "9" "5" "221" "25.5" "11.85" "26.43" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "0" "0.956" "1.101" "1.040" "0.998" "1.168" "1.010" "1.013" "1.117" "0.861" "400.9" "383.2" "441.2" "416.8" "400.2" "468.1" "405.0" "406.3" "447.7" "345.0" "" "" "" "" "" "" "" "" "" "" "361.9" "295.6" "341.3" "280.7" "333.8" "399.5" "343.5" "294.0" "302.0" "345.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-116543853618974429" "False" "High" "IsMasterProtein" "P20338" "Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3" "0.000" "False" "14.933" "10" "2" "3" "1" "218" "24.4" "6.07" "10.12" "2" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5867" "ENSG00000168118" "RAB4A" "hsa:5867; P20338; Q5T7P7; Q9BQ44" "TBC/RABGAPs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane; MET receptor recycling" "VEGFA-VEGFR2 signaling; Insulin signaling; Intracellular trafficking proteins involved in CMT neuropathy; 16p11.2 distal deletion syndrome" "9" "0" "1.031" "1.062" "1.195" "0.972" "1.113" "1.175" "1.078" "1.266" "0.697" "76.5" "78.9" "81.3" "91.5" "74.4" "85.1" "89.9" "82.5" "96.9" "53.3" "" "" "" "" "" "" "" "" "" "" "69.1" "60.8" "62.9" "61.6" "62.0" "72.7" "76.3" "59.7" "65.3" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122244859069195901" "False" "High" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "0.000" "False" "14.927" "17" "5" "7" "5" "304" "34.7" "8.53" "20.71" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "1.019" "1.025" "1.109" "1.095" "0.947" "1.068" "1.081" "1.076" "1.137" "199.2" "203.0" "204.3" "220.9" "218.1" "188.7" "212.7" "215.3" "214.3" "226.5" "" "" "" "" "" "" "" "" "" "" "179.8" "156.6" "158.0" "148.7" "181.9" "161.1" "180.5" "155.8" "144.6" "226.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7197122219504261731" "False" "High" "IsMasterProtein" "Q96EK9" "Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1" "0.000" "False" "14.920" "17" "4" "5" "4" "354" "38.6" "6.95" "11.34" "4" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf08433" "112970" "ENSG00000198841" "KTI12" "hsa:112970; Q96EK9" "" "" "0" "0" "1.008" "0.944" "1.096" "0.973" "0.991" "1.042" "0.993" "1.027" "1.355" "130.6" "131.7" "123.3" "143.2" "127.1" "129.4" "136.2" "129.7" "134.2" "177.1" "" "" "" "" "" "" "" "" "" "" "117.9" "101.6" "95.4" "96.4" "106.0" "110.4" "115.5" "93.9" "90.5" "177.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7224643183628006691" "False" "High" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "0.000" "False" "14.913" "5" "1" "5" "1" "357" "37.5" "5.45" "15.52" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "9" "0" "1.607" "1.305" "1.665" "1.663" "1.047" "1.292" "1.019" "1.211" "4.119" "17.0" "27.2" "22.1" "28.2" "28.2" "17.7" "21.9" "17.3" "20.5" "69.8" "" "" "" "" "" "" "" "" "" "" "15.3" "21.0" "17.1" "19.0" "23.5" "15.1" "18.6" "12.5" "13.8" "69.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7256809200695467141" "False" "High" "IsMasterProtein" "Q02083" "N-acylethanolamine-hydrolyzing acid amidase OS=Homo sapiens OX=9606 GN=NAAA PE=1 SV=3" "0.000" "False" "14.880" "13" "5" "6" "5" "359" "40.0" "8.75" "16.33" "5" "other metabolic processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "27163" "ENSG00000138744" "NAAA" "hsa:27163; Q02083; Q5KTF2; Q96EY2; Q9BRA8" "Neurotransmitter release cycle" "" "1" "0" "1.086" "1.020" "1.156" "1.028" "1.123" "1.047" "1.296" "1.160" "0.860" "178.2" "193.5" "181.7" "206.0" "183.1" "200.1" "186.6" "231.0" "206.7" "153.2" "" "" "" "" "" "" "" "" "" "" "160.9" "149.3" "140.6" "138.7" "152.8" "170.8" "158.3" "167.2" "139.4" "153.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6226740505465900925" "False" "High" "IsMasterProtein" "Q08170" "Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2" "0.000" "False" "14.877" "10" "5" "5" "1" "494" "56.6" "11.52" "14.93" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6429" "ENSG00000116350" "SRSF4" "hsa:6429; Q08170; Q5VXP1; Q9BUA4; Q9UEB5" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "1.305" "0.993" "1.057" "1.127" "1.071" "1.120" "0.806" "0.798" "1.328" "16.8" "21.9" "16.7" "17.8" "18.9" "18.0" "18.8" "13.6" "13.4" "22.3" "" "" "" "" "" "" "" "" "" "" "15.2" "16.9" "12.9" "12.0" "15.8" "15.4" "16.0" "9.8" "9.0" "22.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279905099390366435" "False" "High" "IsMasterProtein" "Q6FIF0" "AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2" "0.000" "False" "14.838" "21" "3" "3" "3" "208" "22.5" "7.20" "12.93" "3" "cell organization and biogenesis;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "54469" "ENSG00000086666" "ZFAND6" "D3DW92; D3DW94; hsa:54469; O95792; Q6FIF0; Q9BQF7; Q9GZY3" "Peroxisomal protein import" "" "1" "0" "1.003" "1.040" "1.069" "1.096" "1.017" "1.067" "1.126" "0.972" "0.795" "362.1" "363.3" "376.6" "387.2" "396.8" "368.3" "386.3" "407.6" "351.9" "287.8" "" "" "" "" "" "" "" "" "" "" "326.9" "280.2" "291.3" "260.7" "331.0" "314.3" "327.7" "295.0" "237.4" "287.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2243304084648640018" "False" "High" "IsMasterProtein" "P49585" "Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2" "0.000" "False" "14.834" "11" "4" "6" "4" "367" "41.7" "7.25" "16.28" "4" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01467" "5130" "ENSG00000161217" "PCYT1A" "A9LYK9; D3DXB1; hsa:5130; P49585; Q86Y88" "Synthesis of PC" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids; 3q29 copy number variation syndrome; Acetylcholine synthesis" "7" "0" "0.861" "0.765" "1.092" "0.951" "0.718" "0.925" "0.872" "0.721" "0.957" "190.6" "164.0" "145.9" "208.2" "181.2" "136.9" "176.3" "166.1" "137.5" "182.5" "" "" "" "" "" "" "" "" "" "" "172.1" "126.5" "112.8" "140.2" "151.2" "116.9" "149.6" "120.2" "92.7" "182.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634393773107864734" "False" "High" "IsMasterProtein" "P19474" "E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1" "0.000" "False" "14.790" "8" "4" "4" "4" "475" "54.1" "6.38" "13.29" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00622, Pf00643, Pf13765" "6737" "ENSG00000132109" "TRIM21" "hsa:6737; P19474; Q5XPV5; Q96RF8" "Interferon gamma signaling; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Regulation of innate immune responses to cytosolic DNA; STING mediated induction of host immune responses" "" "5" "0" "1.103" "0.991" "0.982" "0.971" "1.002" "0.876" "0.686" "1.081" "1.840" "145.1" "160.0" "143.7" "142.4" "140.8" "145.3" "127.1" "99.6" "156.8" "267.0" "" "" "" "" "" "" "" "" "" "" "130.9" "123.5" "111.2" "95.9" "117.5" "124.0" "107.8" "72.0" "105.7" "267.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4795865386403905334" "False" "High" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "0.000" "False" "14.767" "27" "4" "8" "4" "139" "15.3" "9.99" "18.42" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "Ciliary landscape" "3" "0" "1.116" "1.028" "1.121" "1.109" "1.051" "1.125" "1.253" "0.963" "0.696" "579.3" "646.7" "595.3" "649.2" "642.2" "609.1" "651.9" "726.1" "558.1" "403.4" "" "" "" "" "" "" "" "" "" "" "522.9" "498.8" "460.4" "437.1" "535.7" "519.9" "553.0" "525.5" "376.4" "403.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "10965468186403699" "False" "High" "IsMasterProtein" "Q8WY54" "Protein phosphatase 1E OS=Homo sapiens OX=9606 GN=PPM1E PE=1 SV=3" "0.000" "False" "14.764" "4" "2" "3" "2" "755" "83.9" "5.01" "10.63" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00481" "22843" "ENSG00000175175" "PPM1E" "A7E2X1; hsa:22843; Q68DW1; Q7LAF3; Q8WY54; Q9UPT0" "Negative regulation of NMDA receptor-mediated neuronal transmission" "" "1" "0" "1.150" "0.927" "1.119" "1.074" "1.052" "1.076" "1.035" "1.136" "0.819" "143.1" "164.7" "132.6" "160.2" "153.8" "150.6" "154.0" "148.2" "162.6" "117.3" "" "" "" "" "" "" "" "" "" "" "129.2" "127.0" "102.6" "107.9" "128.3" "128.5" "130.6" "107.2" "109.7" "117.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3800161177308876944" "False" "High" "IsMasterProtein" "Q8NEM2" "SHC SH2 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SHCBP1 PE=1 SV=3" "0.000" "False" "14.763" "6" "4" "4" "4" "672" "75.6" "4.75" "13.92" "4" "signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13229" "79801" "ENSG00000171241" "SHCBP1" "hsa:79801; Q8NEM2; Q96N60; Q9BVS0; Q9H6P6" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "1.020" "0.594" "0.974" "0.916" "0.604" "1.049" "0.918" "0.599" "1.882" "334.1" "340.9" "198.5" "325.4" "306.0" "201.9" "350.5" "306.6" "200.1" "628.8" "" "" "" "" "" "" "" "" "" "" "301.6" "263.0" "153.5" "219.1" "255.3" "172.3" "297.4" "221.9" "134.9" "628.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5453029631849906368" "False" "High" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "0.000" "False" "14.756" "12" "4" "5" "4" "309" "35.8" "6.80" "17.08" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "Vitamin B5 (pantothenate) metabolism" "" "1" "0" "1.051" "1.027" "1.073" "1.076" "1.007" "1.048" "1.022" "1.019" "0.933" "397.7" "418.0" "408.3" "426.6" "427.7" "400.6" "416.9" "406.6" "405.3" "371.0" "" "" "" "" "" "" "" "" "" "" "359.0" "322.4" "315.8" "287.3" "356.8" "341.9" "353.7" "294.3" "273.4" "371.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563010740913614584" "False" "High" "IsMasterProtein" "Q96EB6" "NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2" "0.000" "False" "14.726" "5" "4" "4" "4" "747" "81.6" "4.67" "13.18" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23411" "ENSG00000096717" "SIRT1" "hsa:23411; Q2XNF6; Q5JVQ0; Q96EB6; Q9GZR9; Q9Y6F0" "Regulation of HSF1-mediated heat shock response; SIRT1 negatively regulates rRNA expression; Heme signaling; Circadian Clock; Regulation of FOXO transcriptional activity by acetylation" "Androgen receptor signaling pathway; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Melatonin metabolism and effects; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Interactions between LOXL4 and oxidative stress pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; CAMKK2 pathway; 3q29 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Inclusion body myositis; Prostaglandin and leukotriene metabolism in senescence ; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; 10q11.21q11.23 copy number variation syndrome; TAR syndrome; Omega-6-fatty acids in senescence" "27" "0" "0.951" "0.900" "1.268" "0.995" "0.855" "1.046" "0.964" "0.889" "1.355" "165.6" "157.4" "149.1" "210.0" "164.7" "141.6" "173.3" "159.7" "147.2" "224.4" "" "" "" "" "" "" "" "" "" "" "149.5" "121.4" "115.3" "141.4" "137.4" "120.9" "147.0" "115.6" "99.3" "224.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1675638052339020088" "False" "High" "IsMasterProtein" "O75146" "Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2" "0.000" "False" "14.714" "3" "4" "6" "4" "1068" "119.3" "6.67" "17.94" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01608, Pf07651, Pf16515" "9026" "ENSG00000130787" "HIP1R" "A6NHQ6; hsa:9026; O75146; Q6NXG8; Q9UED9" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "5q35 copy number variation" "3" "0" "0.913" "0.907" "0.823" "0.939" "0.783" "0.969" "1.010" "0.804" "1.153" "250.6" "228.9" "227.3" "206.3" "235.3" "196.1" "242.8" "253.2" "201.5" "289.0" "" "" "" "" "" "" "" "" "" "" "226.2" "176.6" "175.8" "138.9" "196.3" "167.4" "205.9" "183.2" "135.9" "289.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988344905656775202" "False" "High" "IsMasterProtein" "Q92665" "Small ribosomal subunit protein mS31 OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "0.000" "False" "14.709" "13" "4" "5" "4" "395" "45.3" "9.29" "13.26" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.010" "0.947" "0.793" "1.054" "1.002" "0.883" "1.107" "0.810" "1.367" "49.6" "50.1" "47.0" "39.3" "52.3" "49.7" "43.8" "54.9" "40.2" "67.8" "" "" "" "" "" "" "" "" "" "" "44.8" "38.6" "36.3" "26.5" "43.6" "42.4" "37.1" "39.7" "27.1" "67.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667668452715930583" "False" "High" "IsMasterProtein" "O60264" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1" "0.000" "False" "14.709" "3" "4" "4" "4" "1052" "121.8" "8.09" "12.84" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "8467" "ENSG00000153147" "SMARCA5" "hsa:8467; O60264" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression" "10q11.21q11.23 copy number variation syndrome" "5" "0" "0.892" "1.083" "1.182" "0.994" "0.911" "0.897" "0.608" "1.022" "6.670" "49.4" "44.1" "53.5" "58.4" "49.1" "45.0" "44.3" "30.0" "50.5" "329.4" "" "" "" "" "" "" "" "" "" "" "44.6" "34.0" "41.4" "39.3" "41.0" "38.4" "37.6" "21.7" "34.0" "329.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2604748441743257015" "False" "High" "IsMasterProtein" "Q6P1J9" "Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1" "0.000" "False" "14.676" "7" "4" "4" "4" "531" "60.5" "9.61" "13.05" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05179, Pf16050" "79577" "ENSG00000134371" "CDC73" "A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7" "Hedgehog 'on' state; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex" "Endoderm differentiation" "7" "0" "1.106" "1.145" "1.651" "1.234" "0.884" "1.533" "0.821" "1.064" "7.333" "19.2" "21.2" "22.0" "31.7" "23.7" "17.0" "29.4" "15.8" "20.4" "140.7" "" "" "" "" "" "" "" "" "" "" "17.3" "16.4" "17.0" "21.3" "19.8" "14.5" "24.9" "11.4" "13.8" "140.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1756983135160374971" "False" "High" "IsMasterProtein" "Q8NBJ5" "Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1" "0.000" "False" "14.605" "7" "4" "6" "4" "622" "71.6" "7.31" "13.95" "4" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf01755, Pf13704" "79709" "ENSG00000130309" "COLGALT1" "hsa:79709; Q8NBJ5; Q8NC64" "Collagen biosynthesis and modifying enzymes" "Type I collagen synthesis in the context of osteogenesis imperfecta" "2" "0" "1.038" "1.045" "1.191" "1.035" "0.971" "1.107" "1.052" "0.920" "1.482" "143.1" "148.4" "149.6" "170.4" "148.1" "138.9" "158.3" "150.6" "131.6" "212.1" "" "" "" "" "" "" "" "" "" "" "129.1" "114.5" "115.7" "114.7" "123.6" "118.5" "134.3" "109.0" "88.8" "212.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7866800410965669169" "False" "High" "IsMasterProtein" "Q9H0G5" "Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1" "0.000" "False" "14.604" "7" "4" "5" "4" "558" "66.4" "8.84" "10.41" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09745, Pf20427" "84081" "ENSG00000126653" "NSRP1" "hsa:84081; Q6FI71; Q9H0G5" "mRNA Splicing - Major Pathway" "" "1" "0" "0.936" "1.215" "0.936" "0.953" "0.989" "0.821" "0.943" "1.142" "0.870" "261.6" "244.9" "317.9" "244.8" "249.3" "258.8" "214.9" "246.7" "298.9" "227.7" "" "" "" "" "" "" "" "" "" "" "236.2" "188.9" "245.9" "164.8" "208.0" "220.9" "182.3" "178.5" "201.6" "227.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037258603534985886" "False" "High" "IsMasterProtein" "Q12974" "Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1" "0.000" "False" "14.599" "25" "4" "5" "4" "167" "19.1" "8.37" "17.35" "4" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102" "8073" "ENSG00000184007" "PTP4A2" "A8K9I8; B4DM39; D3DPP0; E9PGJ6; hsa:8073; O00649; Q12974; Q15197; Q15259; Q15260; Q15261; R4GN50" "RAB geranylgeranylation" "" "1" "0" "1.012" "1.053" "0.766" "1.063" "1.092" "1.072" "1.132" "0.985" "0.741" "276.2" "279.3" "290.7" "211.5" "293.5" "301.7" "296.0" "312.6" "272.0" "204.5" "" "" "" "" "" "" "" "" "" "" "249.3" "215.5" "224.8" "142.4" "244.8" "257.5" "251.1" "226.2" "183.5" "204.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6789229082663828317" "False" "High" "IsMasterProtein" "Q6ZUJ8" "Phosphoinositide 3-kinase adapter protein 1 OS=Homo sapiens OX=9606 GN=PIK3AP1 PE=1 SV=2" "0.000" "False" "14.582" "5" "3" "3" "3" "805" "90.3" "5.40" "12.64" "3" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "118788" "ENSG00000155629" "PIK3AP1" "hsa:118788; Q5TB56; Q5VXJ9; Q6ZUJ8; Q8N6J6; Q8NAC8" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "B cell receptor signaling pathway; PI3K-Akt signaling pathway" "6" "0" "0.902" "0.902" "1.227" "0.962" "1.021" "0.973" "0.816" "1.097" "3.436" "40.2" "36.3" "36.3" "49.4" "38.7" "41.1" "39.1" "32.8" "44.1" "138.2" "" "" "" "" "" "" "" "" "" "" "36.3" "28.0" "28.0" "33.2" "32.3" "35.0" "33.2" "23.7" "29.8" "138.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145009283245857027" "False" "High" "IsMasterProtein" "P62487" "DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1" "0.000" "False" "14.575" "20" "3" "4" "3" "172" "19.3" "5.54" "11.22" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00575, Pf03876" "5436" "ENSG00000168002" "POLR2G" "B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.699" "0.997" "1.270" "1.105" "1.351" "1.153" "0.811" "1.244" "0.830" "60.7" "103.2" "60.5" "77.1" "67.1" "82.0" "70.0" "49.2" "75.5" "50.4" "" "" "" "" "" "" "" "" "" "" "54.8" "79.6" "46.8" "51.9" "56.0" "70.0" "59.4" "35.6" "50.9" "50.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2950951748836187489" "False" "High" "IsMasterProtein" "Q96MG7" "Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1" "0.000" "False" "14.571" "14" "3" "3" "3" "304" "34.3" "9.28" "8.04" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01454" "56160" "ENSG00000185115; ENSG00000282130" "NSMCE3" "hsa:56160; Q8IW16; Q8TEI6; Q96MG7; Q9H214" "SUMOylation of DNA damage response and repair proteins" "15q11q13 copy number variation" "2" "0" "0.735" "0.869" "0.905" "0.861" "0.986" "0.837" "0.730" "1.006" "0.849" "90.3" "66.4" "78.5" "81.7" "77.8" "89.0" "75.5" "65.9" "90.9" "76.7" "" "" "" "" "" "" "" "" "" "" "81.5" "51.2" "60.7" "55.0" "64.9" "76.0" "64.1" "47.7" "61.3" "76.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244898098371361519" "False" "High" "IsMasterProtein" "Q86VS8" "Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2" "0.000" "False" "14.569" "6" "5" "7" "5" "718" "83.1" "5.17" "19.93" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "84376" "ENSG00000168172" "HOOK3" "D3DSY8; hsa:84376; Q86VS8; Q8NBH0; Q9BY13" "" "" "0" "0" "0.958" "1.003" "1.093" "0.985" "0.939" "1.001" "0.905" "0.967" "1.511" "292.4" "280.1" "293.3" "319.7" "288.0" "274.5" "292.6" "264.7" "282.7" "441.7" "" "" "" "" "" "" "" "" "" "" "263.9" "216.0" "226.8" "215.3" "240.3" "234.3" "248.2" "191.5" "190.7" "441.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4679234799158284053" "False" "High" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "0.000" "False" "14.564" "10" "3" "4" "3" "285" "33.3" "5.86" "13.03" "3" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "1.031" "1.011" "1.208" "1.025" "1.027" "1.007" "1.048" "0.930" "0.691" "290.3" "299.4" "293.6" "350.5" "297.6" "298.3" "292.5" "304.2" "269.9" "200.6" "" "" "" "" "" "" "" "" "" "" "262.0" "230.9" "227.1" "236.1" "248.3" "254.6" "248.1" "220.2" "182.1" "200.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4340156669496060526" "False" "High" "IsMasterProtein" "Q9Y3C6" "Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1" "0.000" "False" "14.536" "30" "5" "5" "5" "166" "18.2" "7.99" "14.42" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "other molecular function" "Pf00160" "51645" "ENSG00000137168" "PPIL1" "hsa:51645; O15001; Q5TDC9; Q9Y3C6" "mRNA Splicing - Major Pathway" "" "1" "0" "0.945" "1.061" "0.949" "0.996" "1.090" "0.922" "0.906" "1.080" "1.416" "296.4" "280.3" "314.7" "281.4" "295.3" "323.1" "273.3" "268.5" "320.1" "419.8" "" "" "" "" "" "" "" "" "" "" "267.6" "216.2" "243.4" "189.5" "246.3" "275.7" "231.8" "194.3" "215.9" "419.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895404278384693276" "False" "High" "IsMasterProtein" "P08047" "Transcription factor Sp1 OS=Homo sapiens OX=9606 GN=SP1 PE=1 SV=3" "0.000" "False" "14.530" "5" "2" "2" "2" "785" "80.6" "7.34" "7.32" "2" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6667" "ENSG00000185591" "SP1" "E4Z9M7; G5E9M8; hsa:6667; P08047; Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7" "PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP); SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Regulation of CDH11 gene transcription; NFE2L2 regulating tumorigenic genes" "Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; IL-17 signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Pathways in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "42" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613056624096108144" "False" "High" "IsMasterProtein" "Q7Z7E8" "Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens OX=9606 GN=UBE2Q1 PE=1 SV=1" "0.000" "False" "14.506" "12" "6" "6" "6" "422" "46.1" "5.10" "16.63" "6" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "55585" "ENSG00000160714" "UBE2Q1" "B4DF92; hsa:55585; Q29SN7; Q3B841; Q5I0X2; Q6IS04; Q6P7P2; Q7Z7E8; Q96MV4; Q9BVX5; Q9UGL6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.976" "0.881" "1.001" "0.923" "0.807" "0.957" "0.878" "0.890" "2.443" "549.1" "535.9" "483.9" "549.8" "506.8" "443.3" "525.3" "482.3" "488.8" "1341.2" "" "" "" "" "" "" "" "" "" "" "495.6" "413.4" "374.3" "370.3" "422.7" "378.4" "445.6" "349.0" "329.7" "1341.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3175822401937946454" "False" "High" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "0.000" "False" "14.500" "6" "4" "4" "4" "572" "61.2" "6.67" "13.23" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "" "Integrin-mediated cell adhesion; Focal adhesion" "2" "0" "1.060" "0.906" "1.067" "0.916" "0.836" "0.945" "0.793" "0.814" "0.778" "176.4" "186.9" "159.7" "188.2" "161.5" "147.4" "166.6" "139.8" "143.6" "137.1" "" "" "" "" "" "" "" "" "" "" "159.2" "144.2" "123.6" "126.8" "134.8" "125.8" "141.4" "101.2" "96.9" "137.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6922732359213996073" "False" "High" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "0.000" "False" "14.490" "3" "3" "3" "3" "1026" "117.3" "5.55" "10.22" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "1.082" "0.803" "1.144" "1.135" "0.852" "1.201" "1.074" "0.885" "2.932" "104.9" "113.5" "84.2" "119.9" "119.1" "89.4" "125.9" "112.7" "92.8" "307.5" "" "" "" "" "" "" "" "" "" "" "94.7" "87.5" "65.2" "80.8" "99.3" "76.3" "106.8" "81.5" "62.6" "307.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1845643412684317790" "False" "High" "IsMasterProtein" "P49674" "Casein kinase I isoform epsilon OS=Homo sapiens OX=9606 GN=CSNK1E PE=1 SV=1" "0.000" "False" "14.482" "8" "3" "3" "3" "416" "47.3" "9.66" "11.31" "3" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "102800317; 1454" "ENSG00000213923" "CSNK1E" "hsa:102800317; hsa:1454; P49674" "Major pathway of rRNA processing in the nucleolus and cytosol; WNT mediated activation of DVL; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock" "Alzheimer's disease and miRNA effects; Melatonin metabolism and effects; Wnt signaling pathway; Wnt signaling pathway and pluripotency; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease" "20" "0" "0.961" "0.890" "1.063" "1.043" "0.866" "0.966" "0.934" "0.873" "1.385" "302.8" "290.9" "269.4" "321.8" "315.7" "262.1" "292.4" "282.8" "264.4" "419.3" "" "" "" "" "" "" "" "" "" "" "273.3" "224.4" "208.4" "216.7" "263.4" "223.7" "248.0" "204.6" "178.4" "419.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-77584884133553683" "False" "High" "IsMasterProtein" "Q9UMY4" "Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12 PE=1 SV=4" "0.000" "False" "14.473" "30" "5" "6" "3" "162" "18.9" "8.44" "17.59" "5" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29934" "ENSG00000147164" "SNX12" "F8W8K5; hsa:29934; Q8WUG9; Q9UMY4" "" "" "0" "0" "0.903" "0.872" "1.049" "0.873" "0.848" "1.048" "0.986" "0.823" "1.276" "272.1" "245.7" "237.2" "285.6" "237.5" "230.8" "285.3" "268.3" "224.0" "347.2" "" "" "" "" "" "" "" "" "" "" "245.6" "189.5" "183.5" "192.3" "198.1" "197.0" "242.0" "194.2" "151.1" "347.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2503112779916804665" "False" "High" "IsMasterProtein" "Q8WV28" "B-cell linker protein OS=Homo sapiens OX=9606 GN=BLNK PE=1 SV=2" "0.000" "False" "14.457" "11" "6" "11" "6" "456" "50.4" "8.16" "30.49" "6" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017" "29760" "ENSG00000095585" "BLNK" "hsa:29760; O75498; O75499; Q2MD49; Q8WV28" "Regulation of signaling by CBL; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "5" "0" "0.970" "0.952" "0.981" "0.949" "0.930" "0.922" "1.006" "0.960" "0.783" "1124.3" "1090.6" "1070.7" "1103.1" "1066.8" "1045.5" "1036.8" "1131.3" "1079.5" "880.6" "" "" "" "" "" "" "" "" "" "" "1014.9" "841.2" "828.1" "742.8" "889.9" "892.4" "879.5" "818.7" "728.1" "880.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1844756928667547842" "False" "High" "IsMasterProtein" "Q9NWU1" "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1" "0.000" "False" "14.430" "7" "2" "2" "2" "459" "48.8" "7.66" "7.74" "2" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00109, Pf02801" "54995" "ENSG00000151093" "OXSM" "Q9NWU1" "Mitochondrial protein degradation" "Mitochondrial fatty acid synthesis pathway" "2" "0" "0.995" "0.975" "1.053" "1.055" "1.139" "0.905" "1.107" "1.030" "0.772" "124.4" "123.7" "121.4" "131.1" "131.3" "141.7" "112.6" "137.8" "128.2" "96.1" "" "" "" "" "" "" "" "" "" "" "112.3" "95.4" "93.9" "88.3" "109.5" "121.0" "95.5" "99.7" "86.5" "96.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276719871576654886" "False" "High" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "0.000" "False" "14.423" "5" "2" "6" "2" "476" "52.2" "6.15" "22.03" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394; ENSG00000292204" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.123" "1.413" "1.248" "1.171" "1.418" "1.114" "0.990" "1.405" "2.129" "214.0" "240.3" "302.3" "267.0" "250.6" "303.4" "238.3" "211.9" "300.6" "455.6" "" "" "" "" "" "" "" "" "" "" "193.2" "185.4" "233.8" "179.8" "209.1" "259.0" "202.2" "153.3" "202.7" "455.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3161881869701219173" "False" "High" "IsMasterProtein" "O43715" "TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1" "0.000" "False" "14.417" "37" "3" "6" "3" "76" "8.8" "5.48" "18.64" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05254" "51499" "ENSG00000170855" "TRIAP1" "B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "5q35 copy number variation" "3" "0" "0.980" "0.906" "1.194" "0.944" "0.876" "0.978" "1.171" "0.951" "0.738" "456.5" "447.5" "413.7" "545.0" "431.1" "399.9" "446.7" "534.7" "434.3" "337.1" "" "" "" "" "" "" "" "" "" "" "412.1" "345.2" "320.0" "367.0" "359.6" "341.3" "378.9" "387.0" "292.9" "337.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-909250529717419183" "False" "High" "IsMasterProtein" "P26447" "Protein S100-A4 OS=Homo sapiens OX=9606 GN=S100A4 PE=1 SV=1" "0.000" "False" "14.412" "25" "3" "8" "3" "101" "11.7" "6.11" "19.97" "3" "signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01023" "6275" "ENSG00000196154" "S100A4" "A8K7R8; D3DV46; hsa:6275; P26447; Q6ICP8" "" "Vitamin D receptor pathway" "1" "0" "0.962" "1.103" "1.057" "1.042" "1.080" "0.948" "1.094" "1.087" "0.803" "846.4" "814.6" "933.2" "894.3" "881.6" "914.2" "802.4" "925.9" "920.1" "679.5" "" "" "" "" "" "" "" "" "" "" "764.0" "628.3" "721.8" "602.2" "735.4" "780.3" "680.7" "670.1" "620.6" "679.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529586358305545684" "False" "High" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "0.000" "False" "14.380" "5" "2" "4" "2" "439" "48.5" "7.03" "16.39" "2" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Glutamate and glutamine metabolism" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "4" "0" "1.162" "0.839" "1.110" "1.064" "0.847" "1.003" "1.070" "0.937" "0.862" "179.0" "208.0" "150.2" "198.7" "190.5" "151.6" "179.5" "191.4" "167.8" "154.4" "" "" "" "" "" "" "" "" "" "" "161.6" "160.5" "116.2" "133.8" "158.9" "129.4" "152.3" "138.5" "113.2" "154.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547053484993874983" "False" "High" "IsMasterProtein" "Q13085" "Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2" "0.000" "False" "14.362" "2" "4" "4" "4" "2346" "265.4" "6.37" "10.31" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf21385" "31" "ENSG00000275176; ENSG00000278540" "ACACA" "B2RP68; B2ZZ90; hsa:31; Q13085; Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3" "ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; Defective HLCS causes multiple carboxylase deficiency" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome; 17q12 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ADHD and autism (ASD) linked metabolic pathways and SNP" "24" "0" "0.999" "0.917" "0.997" "0.903" "0.916" "1.004" "0.806" "0.869" "4.841" "129.9" "129.7" "119.1" "129.5" "117.3" "119.0" "130.5" "104.8" "112.9" "628.8" "" "" "" "" "" "" "" "" "" "" "117.3" "100.1" "92.1" "87.2" "97.8" "101.6" "110.7" "75.8" "76.1" "628.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4732323992224053242" "False" "High" "IsMasterProtein" "Q9NU22" "Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2" "0.000" "False" "14.350" "1" "4" "4" "4" "5596" "632.4" "5.68" "12.33" "4" "cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07728, Pf17865, Pf17867, Pf21108" "23195" "ENSG00000112159" "MDN1" "hsa:23195; O15019; Q5T794; Q9NU22" "" "" "0" "0" "1.127" "0.964" "1.125" "1.088" "1.079" "1.118" "0.889" "0.979" "1.957" "116.0" "130.7" "111.8" "130.4" "126.2" "125.1" "129.7" "103.1" "113.5" "227.0" "" "" "" "" "" "" "" "" "" "" "104.7" "100.8" "86.4" "87.8" "105.3" "106.8" "110.0" "74.6" "76.5" "227.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7106533515535511067" "False" "High" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "0.000" "False" "14.341" "10" "2" "5" "2" "191" "20.9" "4.39" "17.07" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "1.117" "0.939" "1.164" "1.207" "0.879" "1.193" "1.141" "0.903" "1.224" "103.0" "115.1" "96.7" "120.0" "124.4" "90.6" "122.8" "117.5" "93.1" "126.1" "" "" "" "" "" "" "" "" "" "" "93.0" "88.8" "74.8" "80.8" "103.7" "77.3" "104.2" "85.1" "62.8" "126.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8481404637455697567" "False" "High" "IsMasterProtein" "Q9C0B1" "Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3" "0.000" "False" "14.340" "8" "5" "5" "5" "505" "58.2" "5.22" "13.30" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12933, Pf12934" "79068" "ENSG00000140718" "FTO" "A2RUH1; B2RNS0; hsa:79068; Q0P676; Q7Z785; Q9C0B1" "Reversal of alkylation damage by DNA dioxygenases" "FTO obesity variant mechanism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2011789362582396358" "False" "High" "IsMasterProtein" "Q9NSI8" "SAM domain-containing protein SAMSN-1 OS=Homo sapiens OX=9606 GN=SAMSN1 PE=1 SV=1" "0.000" "False" "14.337" "8" "3" "4" "3" "373" "41.7" "5.43" "13.76" "3" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07647, Pf07653, Pf12485" "64092" "ENSG00000155307" "SAMSN1" "B3KWJ3; F8WAA1; hsa:64092; Q8NFF7; Q9C041; Q9NSI8" "" "TYROBP causal network in microglia" "1" "0" "0.916" "0.979" "1.049" "1.008" "0.944" "0.963" "0.862" "1.055" "1.217" "90.7" "83.1" "88.7" "95.1" "91.4" "85.6" "87.3" "78.1" "95.7" "110.4" "" "" "" "" "" "" "" "" "" "" "81.8" "64.1" "68.6" "64.0" "76.3" "73.0" "74.1" "56.5" "64.5" "110.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7053379414769105992" "False" "High" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "0.000" "False" "14.286" "12" "3" "4" "3" "334" "37.6" "6.54" "10.86" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; Neddylation; DNA Damage Recognition in GG-NER" "TGF-beta signaling pathway" "5" "0" "0.902" "0.932" "1.055" "1.007" "1.037" "1.116" "0.946" "0.891" "0.726" "300.1" "270.6" "279.7" "316.7" "302.3" "311.1" "334.9" "283.8" "267.5" "217.9" "" "" "" "" "" "" "" "" "" "" "270.9" "208.7" "216.3" "213.3" "252.2" "265.5" "284.1" "205.4" "180.4" "217.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-981252296573627161" "False" "High" "IsMasterProtein" "Q8NCN4" "E3 ubiquitin-protein ligase RNF169 OS=Homo sapiens OX=9606 GN=RNF169 PE=1 SV=2" "0.000" "False" "14.284" "6" "4" "4" "4" "708" "77.1" "9.10" "13.58" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13920" "254225" "ENSG00000166439" "RNF169" "hsa:254225; Q6N015; Q8NCN4" "" "" "0" "0" "1.295" "1.293" "1.118" "1.296" "1.236" "1.188" "1.276" "1.217" "1.321" "167.4" "216.8" "216.5" "187.1" "216.9" "207.0" "198.8" "213.6" "203.8" "221.1" "" "" "" "" "" "" "" "" "" "" "151.1" "167.2" "167.4" "126.0" "180.9" "176.6" "168.7" "154.6" "137.4" "221.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485182549121438413" "False" "High" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "0.000" "False" "14.276" "6" "7" "8" "7" "1098" "123.8" "8.65" "16.48" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "mRNA Splicing - Major Pathway" "" "1" "0" "1.072" "1.001" "1.039" "1.010" "1.050" "0.923" "0.755" "1.029" "4.340" "140.8" "150.9" "140.9" "146.3" "142.2" "147.8" "130.0" "106.3" "144.9" "611.1" "" "" "" "" "" "" "" "" "" "" "127.1" "116.4" "109.0" "98.5" "118.6" "126.1" "110.3" "76.9" "97.7" "611.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7347727386660618652" "False" "High" "IsMasterProtein" "Q8IUI8" "Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2" "0.000" "False" "14.250" "5" "2" "3" "2" "442" "49.7" "5.14" "11.49" "2" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "51379" "ENSG00000176390" "CRLF3" "A6NJF3; B2R8C3; hsa:51379; Q2MLY7; Q8IUI8; Q9UNI3; Q9Y6M8" "" "NF1 copy number variation syndrome" "1" "0" "0.990" "0.897" "0.946" "0.968" "0.881" "0.896" "0.872" "0.950" "3.285" "228.8" "226.5" "205.3" "216.4" "221.4" "201.6" "205.0" "199.5" "217.4" "751.9" "" "" "" "" "" "" "" "" "" "" "206.6" "174.7" "158.8" "145.7" "184.7" "172.1" "173.9" "144.4" "146.6" "751.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6704752873658697689" "False" "High" "IsMasterProtein" "P37268" "Squalene synthase OS=Homo sapiens OX=9606 GN=FDFT1 PE=1 SV=1" "0.000" "False" "14.235" "11" "4" "5" "4" "417" "48.1" "6.54" "12.91" "4" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00494" "2222" "ENSG00000079459; ENSG00000284967" "FDFT1" "B3KQ95; B4DJE5; B4DT56; B7Z1J3; hsa:2222; P37268; Q96GT0" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism; 8p23.1 copy number variation syndrome" "12" "0" "0.903" "0.884" "1.029" "0.768" "0.963" "0.782" "0.954" "0.913" "0.963" "41.8" "37.7" "36.9" "43.0" "32.1" "40.2" "32.7" "39.9" "38.1" "40.2" "" "" "" "" "" "" "" "" "" "" "37.7" "29.1" "28.6" "28.9" "26.8" "34.3" "27.7" "28.8" "25.7" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "51923672491572090" "False" "High" "IsMasterProtein" "Q4J6C6" "Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1" "0.000" "False" "14.231" "6" "4" "4" "4" "727" "83.9" "6.38" "11.41" "4" "protein metabolism;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00326, Pf02897" "9581" "ENSG00000138078" "PREPL" "A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7" "" "Primary ovarian insufficiency" "1" "0" "0.956" "1.000" "0.982" "0.967" "0.972" "1.036" "1.053" "0.971" "1.074" "282.7" "270.3" "282.6" "277.6" "273.3" "274.9" "293.0" "297.7" "274.4" "303.6" "" "" "" "" "" "" "" "" "" "" "255.2" "208.5" "218.6" "186.9" "228.0" "234.6" "248.6" "215.5" "185.1" "303.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "884505446193914017" "False" "High" "IsMasterProtein" "O43752" "Syntaxin-6 OS=Homo sapiens OX=9606 GN=STX6 PE=1 SV=1" "0.000" "False" "14.229" "18" "4" "4" "4" "255" "29.2" "4.93" "10.56" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf09177" "10228" "ENSG00000135823" "STX6" "B2R652; B4DR17; hsa:10228; O43752; Q5VY08; Q6FH83" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "2" "0" "1.013" "1.175" "1.104" "0.920" "1.024" "1.073" "1.007" "1.164" "1.010" "83.4" "84.5" "98.0" "92.1" "76.7" "85.4" "89.6" "84.0" "97.1" "84.3" "" "" "" "" "" "" "" "" "" "" "75.3" "65.2" "75.8" "62.0" "64.0" "72.9" "76.0" "60.8" "65.5" "84.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8899762439150821704" "False" "High" "IsMasterProtein" "Q9H9Q4" "Non-homologous end-joining factor 1 OS=Homo sapiens OX=9606 GN=NHEJ1 PE=1 SV=1" "0.000" "False" "14.228" "5" "1" "2" "1" "299" "33.3" "5.97" "8.24" "1" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09302" "79840" "ENSG00000187736" "NHEJ1" "B8ZZA4; hsa:79840; Q4ZFW7; Q6IA64; Q96JS9; Q9H9Q4" "Nonhomologous End-Joining (NHEJ)" "Non-homologous end joining; DNA repair pathways, full network" "3" "0" "1.053" "1.173" "1.067" "1.319" "1.505" "1.267" "0.857" "0.999" "0.973" "32.6" "34.3" "38.2" "34.8" "43.0" "49.0" "41.3" "27.9" "32.5" "31.7" "" "" "" "" "" "" "" "" "" "" "29.4" "26.5" "29.6" "23.4" "35.8" "41.8" "35.0" "20.2" "21.9" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5875198809388005970" "False" "High" "IsMasterProtein" "Q9H3H3" "UPF0696 protein C11orf68 OS=Homo sapiens OX=9606 GN=C11orf68 PE=1 SV=3" "0.000" "False" "14.223" "11" "3" "5" "3" "292" "31.4" "6.32" "14.46" "3" "" "" "" "Pf08939" "83638" "ENSG00000175573" "C11orf68" "hsa:83638; J3KQG9; Q9BT13; Q9H3H3" "" "" "0" "0" "0.988" "0.916" "1.244" "1.155" "0.956" "1.131" "0.989" "1.175" "0.836" "131.9" "130.3" "120.8" "164.1" "152.3" "126.1" "149.2" "130.4" "154.9" "110.3" "" "" "" "" "" "" "" "" "" "" "119.1" "100.5" "93.4" "110.5" "127.0" "107.6" "126.6" "94.4" "104.5" "110.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021992825547666354" "False" "High" "IsMasterProtein" "Q8TDB6" "E3 ubiquitin-protein ligase DTX3L OS=Homo sapiens OX=9606 GN=DTX3L PE=1 SV=1" "0.000" "False" "14.218" "4" "2" "2" "2" "740" "83.5" "8.06" "10.17" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf13923, Pf18102, Pf21717, Pf21718" "151636" "ENSG00000163840" "DTX3L" "B3KWH6; Q53ZZ3; Q5MJP7; Q8TDB6" "Antigen processing: Ubiquitination & Proteasome degradation" "Notch signaling" "2" "0" "0.932" "3.054" "1.537" "1.314" "3.162" "1.178" "1.366" "2.891" "2.091" "12.6" "11.7" "38.3" "19.3" "16.5" "39.7" "14.8" "17.1" "36.3" "26.3" "" "" "" "" "" "" "" "" "" "" "11.3" "9.0" "29.7" "13.0" "13.8" "33.9" "12.5" "12.4" "24.5" "26.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4323933511445947970" "False" "High" "IsMasterProtein" "P43405" "Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1" "0.000" "False" "14.189" "4" "2" "3" "2" "635" "72.0" "8.25" "8.75" "2" "cell adhesion;cell-cell signaling;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "6850" "ENSG00000165025" "SYK" "hsa:6850; P43405" "FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; DAP12 signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Integrin signaling; Interleukin-2 signaling; Dectin-2 family; FLT3 signaling through SRC family kinases" "IL-5 signaling pathway; RANKL/RANK signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Microglia pathogen phagocytosis pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; IL-2 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "30" "0" "0.849" "0.762" "0.984" "0.986" "0.937" "0.926" "0.260" "1.043" "9.725" "34.4" "29.2" "26.2" "33.8" "33.9" "32.2" "31.8" "8.9" "35.9" "334.4" "" "" "" "" "" "" "" "" "" "" "31.0" "22.5" "20.3" "22.8" "28.3" "27.5" "27.0" "6.5" "24.2" "334.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-145222249138625553" "False" "High" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "0.000" "False" "14.179" "14" "3" "4" "3" "293" "34.2" "9.88" "12.86" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "0.974" "0.971" "0.896" "0.894" "0.875" "0.883" "0.789" "0.989" "1.472" "83.5" "81.3" "81.0" "74.8" "74.6" "73.0" "73.7" "65.8" "82.6" "122.9" "" "" "" "" "" "" "" "" "" "" "75.3" "62.7" "62.7" "50.4" "62.2" "62.3" "62.5" "47.7" "55.7" "122.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6960359147395003723" "False" "High" "IsMasterProtein" "P15498" "Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4" "0.000" "False" "14.176" "4" "4" "4" "4" "845" "98.3" "6.62" "13.84" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621" "7409" "ENSG00000141968" "VAV1" "B4DVK9; hsa:7409; M0QXX6; P15498; Q15860" "Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; Azathioprine ADME; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway" "Prolactin signaling pathway; B cell receptor signaling pathway; Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor signaling pathway" "38" "0" "0.960" "1.046" "0.977" "0.930" "0.919" "1.086" "0.433" "0.989" "9.853" "184.0" "176.7" "192.5" "179.8" "171.1" "169.1" "199.8" "79.7" "182.0" "1813.3" "" "" "" "" "" "" "" "" "" "" "166.1" "136.3" "148.9" "121.1" "142.7" "144.3" "169.5" "57.7" "122.8" "1813.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065453246646173554" "False" "High" "IsMasterProtein" "O15231" "Zinc finger protein 185 OS=Homo sapiens OX=9606 GN=ZNF185 PE=1 SV=3" "0.000" "False" "14.175" "4" "2" "2" "2" "689" "73.5" "7.01" "8.79" "2" "" "cytoskeleton;other cell component" "other molecular function" "" "7739" "ENSG00000147394; ENSG00000292196" "ZNF185" "A4FTV3; A6NME5; B4DLE9; B7Z771; B8K2L9; B8K2M0; B8K2M1; B8K2M2; E9PFR6; F5GXF7; F5GZL4; F8W8V7; H0Y4M8; hsa:7739; O00345; O15231; Q8N1R8; Q9NSD2" "" "" "0" "0" "1.018" "0.943" "1.083" "0.984" "0.887" "0.918" "1.078" "1.065" "0.988" "187.1" "190.5" "176.4" "202.6" "184.1" "166.0" "171.9" "201.8" "199.4" "184.8" "" "" "" "" "" "" "" "" "" "" "168.9" "146.9" "136.4" "136.4" "153.5" "141.6" "145.8" "146.1" "134.5" "184.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5953183427719841951" "False" "High" "IsMasterProtein" "P18615" "Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3" "0.000" "False" "14.164" "11" "4" "4" "4" "380" "43.2" "9.33" "11.64" "4" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7936" "ENSG00000204356; ENSG00000206268; ENSG00000206357; ENSG00000229363; ENSG00000231044; ENSG00000233801" "NELFE" "A2BE08; B4DUN1; B4DYX9; hsa:7936; P18615; Q5JP74; Q5JP75; Q96F56; Q9NPK2" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "16" "0" "1.246" "0.929" "1.009" "0.883" "1.007" "0.950" "0.998" "1.069" "1.769" "72.1" "89.9" "67.0" "72.8" "63.7" "72.6" "68.5" "72.0" "77.1" "127.6" "" "" "" "" "" "" "" "" "" "" "65.1" "69.3" "51.8" "49.0" "53.1" "62.0" "58.1" "52.1" "52.0" "127.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2101401554741180333" "False" "High" "IsMasterProtein" "Q8N5M1" "ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1" "0.000" "False" "14.143" "8" "2" "3" "2" "289" "32.8" "7.09" "12.24" "2" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "" "Pf07542" "91647" "ENSG00000171953" "ATPAF2" "A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1" "" "7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.080" "0.994" "1.114" "0.925" "1.023" "0.978" "0.988" "1.051" "0.766" "199.1" "215.0" "197.9" "221.7" "184.3" "203.7" "194.7" "196.7" "209.3" "152.6" "" "" "" "" "" "" "" "" "" "" "179.7" "165.8" "153.1" "149.3" "153.7" "173.8" "165.2" "142.3" "141.2" "152.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196973949191465790" "False" "High" "IsMasterProtein" "P07686" "Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=4" "0.000" "False" "14.134" "9" "6" "9" "5" "556" "63.1" "6.76" "24.76" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3074" "ENSG00000049860" "HEXB" "hsa:3074; P07686" "Neutrophil degranulation; CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXB causes GM2G2" "Glycosaminoglycan degradation" "7" "0" "1.056" "1.080" "0.940" "1.041" "1.043" "1.018" "1.053" "1.080" "0.811" "292.0" "308.5" "315.4" "274.5" "304.1" "304.7" "297.2" "307.5" "315.4" "236.7" "" "" "" "" "" "" "" "" "" "" "263.6" "237.9" "244.0" "184.9" "253.7" "260.0" "252.1" "222.6" "212.7" "236.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258533483115152097" "False" "High" "IsMasterProtein" "Q53H96" "Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3" "0.000" "False" "14.126" "12" "3" "3" "3" "274" "28.6" "7.72" "8.77" "3" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03807, Pf14748" "65263" "ENSG00000104524; ENSG00000276657" "PYCR3" "B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896" "Glutamate and glutamine metabolism" "" "1" "0" "0.876" "0.815" "0.945" "0.999" "0.877" "0.992" "0.919" "0.962" "0.674" "135.7" "118.9" "110.6" "128.3" "135.5" "119.0" "134.6" "124.7" "130.6" "91.5" "" "" "" "" "" "" "" "" "" "" "122.5" "91.7" "85.5" "86.4" "113.0" "101.6" "114.2" "90.2" "88.1" "91.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6043879365308815932" "False" "High" "IsMasterProtein" "O75818" "Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3" "0.000" "False" "14.110" "6" "1" "2" "1" "363" "41.8" "6.67" "8.30" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08584" "10799" "ENSG00000124787" "RPP40" "hsa:10799; O75818; Q5VX97; Q8WVK8" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "1.040" "0.997" "1.110" "1.132" "0.938" "1.004" "1.336" "0.950" "0.809" "24.9" "25.9" "24.8" "27.6" "28.2" "23.4" "25.0" "33.3" "23.6" "20.1" "" "" "" "" "" "" "" "" "" "" "22.5" "20.0" "19.2" "18.6" "23.5" "19.9" "21.2" "24.1" "16.0" "20.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779708130048871486" "False" "High" "IsMasterProtein" "O43464" "Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2" "0.000" "False" "14.076" "10" "4" "5" "4" "458" "48.8" "10.07" "13.21" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13365, Pf17820" "27429" "ENSG00000115317" "HTRA2" "hsa:27429; O43464; Q9HBZ4; Q9P0Y3; Q9P0Y4" "Mitochondrial protein degradation" "Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity" "6" "0" "0.974" "0.767" "1.026" "0.876" "0.797" "0.988" "1.161" "0.798" "0.717" "106.3" "103.5" "81.5" "109.0" "93.1" "84.7" "105.0" "123.4" "84.8" "76.2" "" "" "" "" "" "" "" "" "" "" "95.9" "79.9" "63.0" "73.4" "77.6" "72.3" "89.0" "89.3" "57.2" "76.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3065352799485715425" "False" "High" "IsMasterProtein" "Q9P0P0" "E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1" "0.000" "False" "14.070" "24" "4" "5" "4" "153" "17.9" "5.06" "17.04" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "51255" "ENSG00000168894" "RNF181" "hsa:51255; Q53H81; Q9P0P0" "E3 ubiquitin ligases ubiquitinate target proteins" "" "1" "0" "1.165" "1.156" "1.132" "1.271" "1.138" "1.168" "1.202" "1.215" "0.813" "298.4" "347.7" "344.8" "337.7" "379.2" "339.6" "348.5" "358.7" "362.6" "242.7" "" "" "" "" "" "" "" "" "" "" "269.4" "268.2" "266.7" "227.4" "316.3" "289.9" "295.6" "259.6" "244.6" "242.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7459111357476572255" "False" "High" "IsMasterProtein" "Q8NFY9" "Kelch repeat and BTB domain-containing protein 8 OS=Homo sapiens OX=9606 GN=KBTBD8 PE=1 SV=2" "0.000" "False" "14.067" "7" "4" "4" "4" "601" "68.8" "6.29" "10.83" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "84541" "ENSG00000163376" "KBTBD8" "B4DTW6; hsa:84541; Q8NFY9; Q96JI5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.070" "0.945" "0.938" "1.058" "0.996" "0.950" "0.955" "0.962" "1.093" "221.0" "236.3" "208.7" "207.2" "233.9" "220.1" "209.9" "211.0" "212.6" "241.6" "" "" "" "" "" "" "" "" "" "" "199.4" "182.3" "161.5" "139.5" "195.1" "187.9" "178.1" "152.7" "143.4" "241.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219092479354345629" "False" "High" "IsMasterProtein" "O94855" "Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2" "0.000" "False" "14.051" "4" "4" "5" "4" "1032" "112.9" "7.25" "17.96" "4" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9871" "ENSG00000150961" "SEC24D" "hsa:9871; O94855; Q8IYI7" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "0.989" "0.856" "1.004" "1.062" "0.940" "1.070" "1.100" "0.864" "1.216" "537.5" "531.6" "460.0" "539.6" "570.8" "505.0" "575.2" "591.1" "464.5" "653.7" "" "" "" "" "" "" "" "" "" "" "485.1" "410.1" "355.8" "363.4" "476.1" "431.0" "487.9" "427.8" "313.3" "653.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585916410181359903" "False" "High" "IsMasterProtein" "Q6IQ49" "Splicing regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1" "0.000" "False" "14.034" "9" "4" "6" "4" "451" "49.7" "6.05" "17.82" "4" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf13019, Pf13297" "163859" "ENSG00000143751" "SDE2" "A8K4P3; hsa:163859; Q5TD36; Q6IQ49; Q6ZS26; Q8NAG7" "mRNA Splicing - Major Pathway" "" "1" "0" "0.654" "0.806" "1.073" "0.840" "1.027" "0.886" "0.826" "0.971" "0.850" "35.8" "23.4" "28.8" "38.4" "30.0" "36.7" "31.7" "29.5" "34.7" "30.4" "" "" "" "" "" "" "" "" "" "" "32.3" "18.1" "22.3" "25.8" "25.1" "31.4" "26.9" "21.4" "23.4" "30.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5541205227018029514" "False" "High" "IsMasterProtein" "Q9H0P0" "Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3" "0.000" "False" "14.008" "11" "3" "4" "3" "336" "37.9" "7.12" "9.37" "3" "other metabolic processes;stress response" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05822" "51251" "ENSG00000122643" "NT5C3A" "A8K253; B2RAA5; B8ZZC4; hsa:51251; Q6IPZ1; Q6NXS6; Q7L3G6; Q9H0P0; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45" "" "" "0" "0" "1.036" "0.679" "0.976" "1.107" "0.634" "0.772" "0.678" "0.718" "1.573" "40.0" "41.4" "27.2" "39.0" "44.2" "25.4" "30.9" "27.1" "28.7" "62.9" "" "" "" "" "" "" "" "" "" "" "36.1" "31.9" "21.0" "26.3" "36.9" "21.6" "26.2" "19.6" "19.3" "62.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9003778122824522310" "False" "High" "IsMasterProtein" "Q9BRT3" "Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1" "0.000" "False" "14.000" "16" "2" "3" "2" "115" "12.4" "4.37" "9.86" "2" "other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf10262" "84299" "ENSG00000141741" "MIEN1" "hsa:84299; Q9BRT3" "" "17q12 copy number variation syndrome" "1" "0" "0.998" "1.090" "1.111" "0.975" "1.098" "1.019" "1.002" "1.325" "0.961" "111.7" "111.5" "121.8" "124.2" "108.9" "122.7" "113.8" "112.0" "148.1" "107.4" "" "" "" "" "" "" "" "" "" "" "100.9" "86.0" "94.2" "83.6" "90.9" "104.7" "96.6" "81.1" "99.9" "107.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9124965961007810906" "False" "High" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "0.000" "False" "13.996" "4" "3" "4" "3" "765" "90.7" "9.31" "12.16" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "SUMOylation of DNA replication proteins" "Ebola virus infection in host; 15q25 copy number variation" "3" "0" "1.071" "2.179" "1.026" "0.998" "2.281" "1.035" "0.609" "2.169" "6.645" "148.3" "158.9" "323.2" "152.1" "148.0" "338.3" "153.6" "90.4" "321.8" "985.7" "" "" "" "" "" "" "" "" "" "" "133.9" "122.6" "250.0" "102.4" "123.5" "288.8" "130.3" "65.4" "217.1" "985.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1272084248319891202" "False" "High" "IsMasterProtein" "Q9UKB1" "F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1" "0.000" "False" "13.986" "8" "4" "4" "4" "542" "62.1" "7.12" "13.03" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf12125, Pf12937" "23291" "ENSG00000072803" "FBXW11" "B2RC98; hsa:23291; Q9P2S8; Q9P2S9; Q9UKB1; Q9Y4C6" "Regulation of PLK1 Activity at G2/M Transition; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "TNF-alpha signaling pathway; VEGFA-VEGFR2 signaling" "12" "0" "1.023" "0.936" "1.021" "1.021" "0.994" "1.101" "1.051" "1.171" "1.126" "97.4" "99.6" "91.2" "99.5" "99.5" "96.8" "107.2" "102.4" "114.0" "109.7" "" "" "" "" "" "" "" "" "" "" "87.9" "76.8" "70.5" "67.0" "83.0" "82.7" "90.9" "74.1" "76.9" "109.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1528073227460313936" "False" "High" "IsMasterProtein" "Q9H9T3" "Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2" "0.000" "False" "13.973" "6" "3" "3" "3" "547" "62.2" "8.88" "10.08" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04055, Pf16199" "55140" "ENSG00000134014" "ELP3" "B4DE19; B4DIG1; E2QRI5; hsa:55140; Q53G84; Q6AWB0; Q9BVF7; Q9H9T3; Q9NVZ1" "HATs acetylate histones" "Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system" "3" "0" "0.999" "0.891" "0.934" "0.949" "1.018" "0.954" "0.999" "1.004" "0.947" "197.9" "197.8" "176.4" "184.8" "187.8" "201.4" "188.7" "197.7" "198.7" "187.4" "" "" "" "" "" "" "" "" "" "" "178.7" "152.6" "136.5" "124.5" "156.6" "171.9" "160.1" "143.1" "134.0" "187.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6567734872650185245" "False" "High" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "0.000" "False" "13.955" "21" "2" "3" "2" "97" "10.9" "9.41" "10.42" "2" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "0.836" "0.880" "1.050" "0.945" "0.885" "1.014" "1.020" "1.131" "0.805" "196.4" "164.3" "172.9" "206.3" "185.6" "173.8" "199.1" "200.3" "222.1" "158.1" "" "" "" "" "" "" "" "" "" "" "177.3" "126.7" "133.7" "138.9" "154.8" "148.3" "168.9" "144.9" "149.8" "158.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200930033631648957" "False" "High" "IsMasterProtein" "Q06413" "Myocyte-specific enhancer factor 2C OS=Homo sapiens OX=9606 GN=MEF2C PE=1 SV=1" "0.000" "False" "13.940" "4" "2" "4" "1" "473" "51.2" "8.03" "14.49" "2" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4208" "ENSG00000081189" "MEF2C" "C9JMZ0; D7F7N5; F8W7V7; hsa:4208; Q06413" "ERK/MAPK targets; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis; Cardiogenesis; MECP2 regulates transcription factors" "Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Prion disease pathway; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GDNF signaling; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6707241685728679125" "False" "High" "IsMasterProtein" "Q9NY93" "Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens OX=9606 GN=DDX56 PE=1 SV=1" "0.000" "False" "13.927" "8" "4" "4" "4" "547" "61.6" "9.26" "11.98" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54606" "ENSG00000136271" "DDX56" "A4D2K9; C9JV95; hsa:54606; Q6IAE2; Q9H9I8; Q9NY93" "" "" "0" "0" "0.760" "0.661" "0.924" "0.908" "0.558" "0.767" "0.891" "0.679" "0.633" "98.1" "74.6" "64.9" "90.7" "89.1" "54.8" "75.3" "87.5" "66.6" "62.2" "" "" "" "" "" "" "" "" "" "" "88.6" "57.6" "50.2" "61.1" "74.3" "46.8" "63.9" "63.3" "44.9" "62.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176718520801112015" "False" "High" "IsMasterProtein" "P11441" "Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1" "0.000" "False" "13.913" "22" "4" "6" "4" "157" "17.8" "8.66" "18.38" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf17840" "8266" "ENSG00000102178" "UBL4A" "hsa:8266; P11441; Q5HY80" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "1" "0" "1.009" "1.318" "1.070" "0.985" "1.227" "1.021" "1.035" "1.247" "1.137" "285.2" "287.9" "375.8" "305.1" "280.9" "349.8" "291.3" "295.1" "355.6" "324.4" "" "" "" "" "" "" "" "" "" "" "257.4" "222.1" "290.6" "205.5" "234.4" "298.6" "247.1" "213.6" "239.8" "324.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6656067604424276740" "False" "High" "IsMasterProtein" "O95365" "Zinc finger and BTB domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZBTB7A PE=1 SV=1" "0.000" "False" "13.904" "6" "2" "3" "2" "584" "61.4" "5.19" "10.33" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "51341" "ENSG00000178951" "ZBTB7A" "D6W619; hsa:51341; O00456; O95365; Q14D41; Q5XG86" "" "IL-18 signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6585156526220186140" "False" "High" "IsMasterProtein" "Q13610" "Periodic tryptophan protein 1 homolog OS=Homo sapiens OX=9606 GN=PWP1 PE=1 SV=1" "0.000" "False" "13.885" "7" "3" "4" "3" "501" "55.8" "4.77" "13.44" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400" "11137" "ENSG00000136045" "PWP1" "A8K3R6; hsa:11137; Q13610; Q7Z3X9" "" "" "0" "0" "0.974" "0.976" "0.805" "0.745" "0.896" "0.779" "0.777" "1.059" "1.229" "383.6" "373.7" "374.5" "308.7" "285.6" "343.6" "298.9" "298.2" "406.2" "471.5" "" "" "" "" "" "" "" "" "" "" "346.3" "288.2" "289.7" "207.9" "238.3" "293.3" "253.6" "215.8" "274.0" "471.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023390433505774979" "False" "High" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "0.000" "False" "13.877" "10" "3" "3" "3" "346" "36.2" "8.79" "10.73" "3" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Citric acid cycle (TCA cycle)" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "3" "0" "1.020" "0.826" "1.045" "0.913" "0.824" "1.022" "0.985" "0.848" "0.756" "240.0" "244.8" "198.2" "250.8" "219.1" "197.7" "245.2" "236.4" "203.5" "181.5" "" "" "" "" "" "" "" "" "" "" "216.6" "188.8" "153.3" "168.9" "182.8" "168.7" "208.0" "171.1" "137.3" "181.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548420804533655280" "False" "High" "IsMasterProtein" "O43353" "Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2" "0.000" "False" "13.875" "8" "4" "4" "3" "540" "61.2" "7.09" "12.97" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00619, Pf07714" "8767" "ENSG00000104312" "RIPK2" "B7Z748; hsa:8767; O43353; Q6UWF0" "Downstream TCR signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1-dependent IKK and NF-kappa-B activation ; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor signaling pathway" "13" "0" "1.068" "0.810" "0.938" "1.036" "0.917" "1.084" "1.025" "1.053" "1.048" "120.1" "128.4" "97.3" "112.7" "124.5" "110.2" "130.3" "123.1" "126.5" "125.9" "" "" "" "" "" "" "" "" "" "" "108.4" "99.0" "75.2" "75.9" "103.8" "94.0" "110.5" "89.1" "85.3" "125.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6978047849896927875" "False" "High" "IsMasterProtein" "O15234" "Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2" "0.000" "False" "13.870" "5" "2" "3" "2" "703" "76.2" "6.48" "16.41" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09405" "22794" "ENSG00000108349" "CASC3" "A8K8R0; O15234" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "6" "0" "0.923" "1.553" "1.627" "1.368" "1.794" "1.293" "1.104" "2.432" "1.180" "43.3" "40.0" "67.2" "70.5" "59.2" "77.7" "56.0" "47.8" "105.3" "51.1" "" "" "" "" "" "" "" "" "" "" "39.1" "30.8" "52.0" "47.5" "49.4" "66.3" "47.5" "34.6" "71.0" "51.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7529838149184307642" "False" "High" "IsMasterProtein" "P04066" "Tissue alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA1 PE=1 SV=4" "0.000" "False" "13.869" "8" "4" "5" "4" "466" "53.7" "6.84" "15.87" "4" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01120, Pf16757" "2517" "ENSG00000179163" "FUCA1" "B2RBG3; hsa:2517; P04066; Q14334; Q14335; Q3LID0; Q8NAC2" "Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway" "p53 transcriptional gene network" "3" "0" "0.965" "0.991" "0.933" "1.037" "1.134" "1.008" "0.912" "1.120" "0.796" "261.5" "252.4" "259.1" "243.9" "271.3" "296.5" "263.6" "238.4" "292.8" "208.3" "" "" "" "" "" "" "" "" "" "" "236.0" "194.7" "200.4" "164.2" "226.3" "253.1" "223.6" "172.5" "197.5" "208.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570011154676120481" "False" "High" "IsMasterProtein" "Q9NRF9" "DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1" "0.000" "False" "13.850" "35" "5" "6" "5" "147" "16.8" "4.74" "16.30" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54107" "ENSG00000148229" "POLE3" "hsa:54107; Q5W0U1; Q8N758; Q8NCE5; Q9NR32; Q9NRF9" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Activation of the pre-replicative complex; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "16" "0" "1.004" "1.044" "0.961" "0.889" "1.075" "0.940" "1.027" "1.022" "0.929" "263.4" "264.3" "275.0" "253.0" "234.2" "283.1" "247.5" "270.3" "269.2" "244.6" "" "" "" "" "" "" "" "" "" "" "237.7" "203.9" "212.7" "170.3" "195.4" "241.6" "209.9" "195.6" "181.6" "244.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7356302297912569782" "False" "High" "IsMasterProtein" "O75400" "Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2" "0.000" "False" "13.850" "3" "3" "3" "3" "957" "108.7" "7.56" "10.89" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00397, Pf01846" "55660" "ENSG00000196504" "PRPF40A" "hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "0.920" "1.702" "0.888" "0.943" "1.895" "0.928" "0.761" "1.613" "3.392" "110.9" "102.0" "188.7" "98.4" "104.5" "210.1" "102.9" "84.3" "178.9" "376.1" "" "" "" "" "" "" "" "" "" "" "100.1" "78.7" "146.0" "66.3" "87.2" "179.3" "87.3" "61.0" "120.6" "376.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4633912985078584352" "False" "High" "IsMasterProtein" "P07948" "Tyrosine-protein kinase Lyn OS=Homo sapiens OX=9606 GN=LYN PE=1 SV=3" "0.000" "False" "13.846" "9" "5" "7" "3" "512" "58.5" "7.11" "16.53" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "4067" "ENSG00000254087" "LYN" "A0AVQ5; hsa:4067; P07948" "FCGR activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Regulation of signaling by CBL; EPHB-mediated forward signaling; GPVI-mediated activation cascade; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Cyclin D associated events in G1; Regulation of KIT signaling; Growth hormone receptor signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Platelet Adhesion to exposed collagen; CD209 (DC-SIGN) signaling; CD28 co-stimulation; Dectin-2 family; PECAM1 interactions; CTLA4 inhibitory signaling" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; GDNF signaling" "45" "0" "0.949" "0.930" "0.987" "1.001" "0.855" "1.086" "1.213" "0.797" "1.054" "137.9" "130.9" "128.3" "136.2" "138.0" "117.9" "149.8" "167.3" "109.9" "145.4" "" "" "" "" "" "" "" "" "" "" "124.5" "101.0" "99.2" "91.7" "115.1" "100.6" "127.1" "121.1" "74.1" "145.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4329245545062110439" "False" "High" "IsMasterProtein" "Q9NQ50" "Large ribosomal subunit protein mL40 OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1" "0.000" "False" "13.842" "11" "2" "2" "2" "206" "24.5" "9.63" "10.96" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf09812" "64976" "ENSG00000185608" "MRPL40" "B3KVZ7; hsa:64976; O95134; Q9NQ50" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "22q11.2 copy number variation syndrome" "4" "0" "1.123" "0.816" "1.022" "0.923" "0.982" "1.018" "0.949" "0.998" "0.790" "109.5" "123.0" "89.3" "111.9" "101.1" "107.5" "111.5" "103.9" "109.3" "86.5" "" "" "" "" "" "" "" "" "" "" "98.9" "94.9" "69.1" "75.4" "84.3" "91.8" "94.6" "75.2" "73.7" "86.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658103532290025162" "False" "High" "IsMasterProtein" "P49770" "Translation initiation factor eIF2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "0.000" "False" "13.833" "8" "3" "4" "3" "351" "39.0" "6.16" "15.62" "3" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Recycling of eIF2:GDP" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome; Primary ovarian insufficiency" "5" "0" "0.974" "0.873" "0.926" "0.956" "0.792" "1.032" "0.960" "0.814" "0.819" "672.1" "654.6" "586.9" "622.2" "642.8" "532.5" "693.4" "644.9" "547.3" "550.6" "" "" "" "" "" "" "" "" "" "" "606.7" "505.0" "453.9" "419.0" "536.2" "454.5" "588.2" "466.7" "369.1" "550.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2492705213444431370" "False" "High" "IsMasterProtein" "Q8TE04" "Pantothenate kinase 1 OS=Homo sapiens OX=9606 GN=PANK1 PE=1 SV=2" "0.000" "False" "13.832" "5" "3" "4" "1" "598" "64.3" "7.56" "12.63" "3" "other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf03630" "53354" "ENSG00000152782" "PANK1" "A6NIP0; hsa:53354; Q7RTX6; Q7Z495; Q8TBQ8; Q8TE04" "Coenzyme A biosynthesis" "" "1" "0" "0.830" "0.848" "0.813" "0.808" "0.817" "0.839" "0.848" "0.818" "0.668" "124.5" "103.3" "105.5" "101.1" "100.5" "101.7" "104.5" "105.6" "101.9" "83.1" "" "" "" "" "" "" "" "" "" "" "112.4" "79.7" "81.6" "68.1" "83.9" "86.8" "88.6" "76.4" "68.7" "83.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-329240465840991374" "False" "High" "IsMasterProtein" "Q6GMV3" "Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1" "0.000" "False" "13.831" "15" "2" "4" "2" "140" "15.8" "9.10" "14.85" "2" "" "" "other molecular function" "Pf01981" "391356" "ENSG00000184924" "PTRHD1" "Q6GMV3" "" "" "0" "0" "0.989" "1.048" "1.014" "0.995" "1.051" "0.940" "1.129" "1.016" "0.734" "360.6" "356.8" "377.9" "365.8" "358.9" "379.0" "338.8" "407.3" "366.5" "264.6" "" "" "" "" "" "" "" "" "" "" "325.5" "275.2" "292.3" "246.3" "299.4" "323.5" "287.4" "294.7" "247.2" "264.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5377293189636928692" "False" "High" "IsMasterProtein" "Q7Z7L8" "Uncharacterized protein C11orf96 OS=Homo sapiens OX=9606 GN=C11orf96 PE=1 SV=3" "0.000" "False" "13.827" "10" "3" "4" "3" "435" "46.1" "9.99" "13.11" "3" "" "" "" "Pf15766" "387763" "" "C11orf96" "Q7Z7L8" "" "" "0" "0" "1.347" "1.248" "1.218" "1.277" "1.302" "1.067" "1.425" "1.317" "0.758" "79.9" "107.7" "99.7" "97.3" "102.0" "104.1" "85.3" "113.9" "105.3" "60.6" "" "" "" "" "" "" "" "" "" "" "72.2" "83.1" "77.1" "65.5" "85.1" "88.8" "72.3" "82.4" "71.0" "60.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8981469479003528624" "False" "High" "IsMasterProtein" "Q9BZE1" "Large ribosomal subunit protein mL37 OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "0.000" "False" "13.827" "11" "5" "5" "5" "423" "48.1" "8.59" "14.63" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.081" "0.975" "1.047" "1.046" "0.970" "1.029" "0.964" "0.962" "0.927" "375.3" "405.7" "365.9" "392.9" "392.4" "364.2" "386.0" "361.9" "360.9" "347.9" "" "" "" "" "" "" "" "" "" "" "338.8" "312.9" "283.0" "264.6" "327.4" "310.8" "327.5" "261.9" "243.4" "347.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974578878725693910" "False" "High" "IsMasterProtein" "P45984" "Mitogen-activated protein kinase 9 OS=Homo sapiens OX=9606 GN=MAPK9 PE=1 SV=2" "0.000" "False" "13.809" "9" "5" "9" "4" "424" "48.1" "5.63" "27.85" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5601" "ENSG00000050748" "MAPK9" "A8K0S3; B5BU66; B5M0B4; D3DWQ8; D3DWQ9; hsa:5601; P45984; Q15708; Q15710; Q15711; Q8N5C5" "Signaling by ALK fusions and activated point mutants; FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy; Alzheimer's disease; GDNF signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway" "66" "1" "0.900" "0.925" "1.016" "0.977" "0.830" "0.929" "1.018" "0.923" "0.877" "511.2" "460.3" "472.8" "519.2" "499.2" "424.4" "474.8" "520.3" "472.0" "448.3" "" "" "" "" "" "" "" "" "" "" "461.5" "355.1" "365.7" "349.6" "416.5" "362.3" "402.8" "376.5" "318.3" "448.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624164927491725104" "False" "High" "IsMasterProtein" "O75449" "Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1" "0.000" "False" "13.809" "9" "5" "5" "5" "491" "55.9" "6.90" "13.89" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "11104" "ENSG00000186625" "KATNA1" "E1P5A3; hsa:11104; O75449; Q5TFA8; Q5TFA9; Q86VN2; Q9NU52" "" "" "0" "0" "1.026" "0.852" "1.010" "1.000" "0.782" "0.980" "1.075" "0.855" "1.058" "274.9" "282.0" "234.2" "277.6" "275.0" "215.1" "269.5" "295.5" "235.0" "290.8" "" "" "" "" "" "" "" "" "" "" "248.2" "217.5" "181.1" "187.0" "229.4" "183.6" "228.6" "213.8" "158.5" "290.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339372435308816495" "False" "High" "IsMasterProtein" "Q8IWT0" "Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2" "0.000" "False" "13.809" "16" "3" "5" "3" "167" "19.5" "4.49" "17.80" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01951" "339487" "ENSG00000176261" "ZBTB8OS" "hsa:339487; Q5TGK5; Q6PDA1; Q8IWS9; Q8IWT0; Q8NEV6; Q8NEV7" "tRNA processing in the nucleus" "" "1" "0" "1.014" "1.000" "0.990" "0.990" "0.994" "0.901" "1.041" "0.975" "0.841" "532.8" "540.2" "532.6" "527.7" "527.7" "529.6" "480.2" "554.7" "519.2" "448.0" "" "" "" "" "" "" "" "" "" "" "480.9" "416.7" "411.9" "355.3" "440.2" "452.0" "407.4" "401.4" "350.2" "448.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6535864909566568035" "False" "High" "IsMasterProtein" "O75367" "Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5" "0.000" "False" "13.803" "11" "3" "4" "3" "369" "39.2" "9.83" "12.43" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00125, Pf01661, Pf16211" "9555" "ENSG00000113648" "MACROH2A1" "hsa:9555; O75367; O75377; Q503A8; Q7Z5E3; Q96D41; Q9H8P3; Q9UP96" "" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "2" "0" "1.042" "1.170" "1.091" "1.062" "1.436" "1.140" "1.045" "1.257" "1.113" "122.5" "127.7" "143.3" "133.6" "130.1" "175.9" "139.7" "128.1" "154.0" "136.4" "" "" "" "" "" "" "" "" "" "" "110.6" "98.5" "110.9" "90.0" "108.6" "150.1" "118.5" "92.7" "103.9" "136.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "247879969936268411" "False" "High" "IsMasterProtein" "O94992" "Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1" "0.000" "False" "13.803" "10" "4" "6" "3" "359" "40.6" "4.89" "18.80" "4" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "10614" "ENSG00000186834" "HEXIM1" "B2R8Y5; hsa:10614; O94992" "" "Initiation of transcription and translation elongation at the HIV-1 LTR" "1" "1" "0.938" "0.971" "0.936" "0.958" "0.973" "0.895" "1.062" "0.967" "0.693" "432.4" "405.5" "419.8" "404.6" "414.1" "420.9" "387.2" "459.4" "418.3" "299.6" "" "" "" "" "" "" "" "" "" "" "390.3" "312.8" "324.7" "272.4" "345.4" "359.3" "328.4" "332.5" "282.1" "299.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010780836197462310" "False" "High" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "0.000" "False" "13.799" "3" "1" "2" "1" "424" "44.4" "8.56" "8.47" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing; 10q22q23 copy number variation" "4" "0" "0.886" "1.102" "0.795" "0.791" "1.048" "0.974" "1.083" "0.728" "0.864" "134.1" "118.9" "147.8" "106.7" "106.1" "140.6" "130.7" "145.3" "97.6" "115.9" "" "" "" "" "" "" "" "" "" "" "121.1" "91.7" "114.3" "71.8" "88.5" "120.0" "110.9" "105.1" "65.9" "115.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8408211072324921186" "False" "High" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "0.000" "False" "13.781" "5" "5" "5" "5" "907" "102.3" "7.14" "13.09" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "ISG15 antiviral mechanism" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "4" "0" "0.887" "0.785" "1.004" "0.857" "0.823" "0.971" "0.581" "0.814" "6.340" "130.5" "115.8" "102.5" "131.1" "111.9" "107.5" "126.7" "75.8" "106.3" "827.4" "" "" "" "" "" "" "" "" "" "" "117.8" "89.3" "79.3" "88.3" "93.3" "91.7" "107.5" "54.8" "71.7" "827.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1901322686263979467" "False" "High" "IsMasterProtein" "Q32P44" "Echinoderm microtubule-associated protein-like 3 OS=Homo sapiens OX=9606 GN=EML3 PE=1 SV=1" "0.000" "False" "13.765" "5" "4" "4" "4" "896" "95.1" "7.12" "11.69" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "256364" "ENSG00000149499" "EML3" "hsa:256364; Q32P44; Q6ZQW7; Q8NA55" "" "" "0" "0" "0.978" "0.813" "0.944" "0.973" "0.917" "0.972" "0.940" "0.859" "1.213" "211.9" "207.4" "172.3" "200.0" "206.3" "194.3" "206.1" "199.3" "182.0" "257.1" "" "" "" "" "" "" "" "" "" "" "191.3" "160.0" "133.2" "134.7" "172.1" "165.8" "174.8" "144.3" "122.8" "257.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2137073451658822686" "False" "High" "IsMasterProtein" "Q01664" "Transcription factor AP-4 OS=Homo sapiens OX=9606 GN=TFAP4 PE=1 SV=2" "0.000" "False" "13.761" "9" "3" "3" "3" "338" "38.7" "5.87" "11.04" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7023" "ENSG00000090447" "TFAP4" "hsa:7023; O60409; Q01664" "" "DYRK1A involvement regarding cell proliferation in brain development" "1" "0" "1.431" "1.515" "1.913" "1.129" "1.200" "1.339" "0.936" "1.544" "1.407" "14.8" "21.2" "22.5" "28.4" "16.7" "17.8" "19.9" "13.9" "22.9" "20.9" "" "" "" "" "" "" "" "" "" "" "13.4" "16.4" "17.4" "19.1" "14.0" "15.2" "16.8" "10.0" "15.4" "20.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1143391152356436137" "False" "High" "IsMasterProtein" "P62837" "Ubiquitin-conjugating enzyme E2 D2 OS=Homo sapiens OX=9606 GN=UBE2D2 PE=1 SV=1" "0.000" "False" "13.747" "12" "2" "3" "1" "147" "16.7" "7.83" "10.94" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7322" "ENSG00000131508" "UBE2D2" "D3DQC9; hsa:7322; P51669; P62837; Q3MN78; Q96RP6" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; CLEC7A (Dectin-1) signaling; Neddylation; Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; IKK complex recruitment mediated by RIP1; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "Proteasome degradation; Ciliary landscape" "16" "0" "1.036" "0.938" "1.164" "0.887" "0.874" "0.957" "0.907" "0.953" "0.826" "68.4" "70.8" "64.1" "79.6" "60.6" "59.7" "65.4" "62.0" "65.1" "56.5" "" "" "" "" "" "" "" "" "" "" "61.7" "54.6" "49.6" "53.6" "50.6" "51.0" "55.5" "44.9" "43.9" "56.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080105971862608535" "False" "High" "IsMasterProtein" "Q9BYJ9" "YTH domain-containing family protein 1 OS=Homo sapiens OX=9606 GN=YTHDF1 PE=1 SV=1" "0.000" "False" "13.697" "6" "4" "8" "1" "559" "60.8" "8.79" "27.69" "4" "cell organization and biogenesis;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "54915" "ENSG00000149658" "YTHDF1" "hsa:54915; Q8N3G5; Q8TBT1; Q96AN4; Q96S57; Q9BTI7; Q9BYJ9; Q9NX79" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561643854279228847" "False" "High" "IsMasterProtein" "P15927" "Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1" "0.000" "False" "13.696" "16" "3" "4" "3" "270" "29.2" "6.15" "12.52" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08784" "6118" "ENSG00000117748" "RPA2" "hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5" "Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Homologous Recombination (HRR); Meiotic recombination; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Activation of the pre-replicative complex; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "38" "0" "1.008" "1.148" "1.168" "1.122" "1.186" "1.012" "1.002" "1.353" "0.906" "42.4" "42.8" "48.7" "49.6" "47.6" "50.3" "42.9" "42.5" "57.4" "38.5" "" "" "" "" "" "" "" "" "" "" "38.3" "33.0" "37.7" "33.4" "39.7" "43.0" "36.4" "30.8" "38.7" "38.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8364917298053465575" "False" "High" "IsMasterProtein" "Q9UQ88" "Cyclin-dependent kinase 11A OS=Homo sapiens OX=9606 GN=CDK11A PE=1 SV=4" "0.000" "False" "13.682" "5" "4" "4" "4" "783" "91.3" "5.36" "13.26" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "728642" "ENSG00000008128" "CDK11A" "hsa:728642; O95227; O95228; O96012; Q12821; Q12853; Q12854; Q2TAJ0; Q5QPR0; Q5QPR1; Q5QPR2; Q9UBC4; Q9UBI3; Q9UEI1; Q9UEI2; Q9UP53; Q9UP54; Q9UP55; Q9UP56; Q9UQ86; Q9UQ87; Q9UQ88; Q9UQ89" "Recruitment of mitotic centrosome proteins and complexes" "1p36 copy number variation syndrome" "2" "0" "1.005" "0.980" "1.052" "0.975" "0.983" "1.047" "0.893" "0.927" "1.889" "96.9" "97.4" "94.9" "101.9" "94.5" "95.2" "101.5" "86.5" "89.8" "183.0" "" "" "" "" "" "" "" "" "" "" "87.5" "75.1" "73.4" "68.6" "78.8" "81.3" "86.1" "62.6" "60.6" "183.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376641896775859350" "False" "High" "IsMasterProtein" "O95104" "SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" "0.000" "False" "13.679" "3" "2" "5" "2" "1147" "125.8" "9.55" "13.87" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "57466" "ENSG00000156304" "SCAF4" "C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8" "" "" "0" "0" "1.014" "2.014" "0.932" "1.388" "1.795" "0.962" "1.147" "1.570" "2.245" "75.7" "76.7" "152.5" "70.5" "105.1" "135.9" "72.8" "86.8" "118.9" "169.9" "" "" "" "" "" "" "" "" "" "" "68.3" "59.2" "117.9" "47.5" "87.6" "116.0" "61.8" "62.8" "80.2" "169.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587567595163417034" "False" "High" "IsMasterProtein" "Q9UIQ6" "Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3" "0.000" "False" "13.679" "4" "4" "4" "4" "1025" "117.3" "5.73" "11.89" "4" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "4012" "ENSG00000113441" "LNPEP" "hsa:4012; O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ6; Q9UIQ7" "Antigen processing: Ubiquitination & Proteasome degradation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Endosomal/Vacuolar pathway" "" "3" "0" "1.019" "1.025" "0.888" "0.865" "0.848" "1.009" "0.983" "0.968" "0.808" "117.4" "119.6" "120.3" "104.2" "101.5" "99.5" "118.5" "115.5" "113.6" "94.9" "" "" "" "" "" "" "" "" "" "" "106.0" "92.3" "93.1" "70.2" "84.7" "84.9" "100.5" "83.6" "76.6" "94.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552389438880602085" "False" "High" "IsMasterProtein" "Q7L5Y1" "Mitochondrial enolase superfamily member 1 OS=Homo sapiens OX=9606 GN=ENOSF1 PE=1 SV=1" "0.000" "False" "13.671" "7" "3" "4" "3" "443" "49.8" "6.48" "11.20" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf02746, Pf13378" "55556" "ENSG00000132199" "ENOSF1" "A6NMP3; A8K9R5; B3KSL6; B3KXE4; D3DUH0; hsa:55556; Q15407; Q15594; Q15595; Q6ZS08; Q7L5Y1; Q9HAS5; Q9HAS6" "" "" "0" "0" "1.174" "1.057" "1.235" "1.130" "1.195" "1.062" "1.005" "1.089" "0.824" "153.9" "180.7" "162.8" "190.1" "173.9" "183.9" "163.5" "154.7" "167.7" "126.9" "" "" "" "" "" "" "" "" "" "" "139.0" "139.4" "125.9" "128.0" "145.1" "157.0" "138.7" "112.0" "113.1" "126.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5123694492544734526" "False" "High" "IsMasterProtein" "Q99417" "c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3" "0.000" "False" "13.665" "28" "3" "4" "3" "103" "12.0" "5.91" "9.57" "3" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "" "26292" "ENSG00000214114" "MYCBP" "B2R4N0; hsa:26292; Q5TA64; Q96HE2; Q99417" "" "Pathways affected in adenoid cystic carcinoma" "1" "0" "1.056" "0.972" "1.038" "1.083" "1.044" "1.052" "1.128" "1.028" "1.271" "120.9" "127.7" "117.6" "125.5" "130.9" "126.2" "127.3" "136.5" "124.4" "153.8" "" "" "" "" "" "" "" "" "" "" "109.2" "98.5" "90.9" "84.5" "109.2" "107.7" "108.0" "98.8" "83.9" "153.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1176830711489117496" "False" "High" "IsMasterProtein" "Q7L1V2" "Vacuolar fusion protein MON1 homolog B OS=Homo sapiens OX=9606 GN=MON1B PE=1 SV=1" "0.000" "False" "13.642" "8" "4" "4" "4" "547" "59.2" "6.29" "11.92" "4" "transport;other biological processes" "other cytoplasmic organelle;other cell component" "" "Pf19036, Pf19037, Pf19038" "22879" "ENSG00000103111" "MON1B" "B4DDZ0; hsa:22879; O94949; Q7L1V2" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.903" "0.682" "0.805" "0.927" "0.846" "0.870" "0.815" "0.700" "0.875" "139.0" "125.6" "94.8" "111.9" "128.9" "117.7" "121.0" "113.3" "97.4" "121.7" "" "" "" "" "" "" "" "" "" "" "125.5" "96.9" "73.4" "75.4" "107.6" "100.4" "102.7" "82.0" "65.7" "121.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7202922108567294127" "False" "High" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "0.000" "False" "13.640" "7" "3" "3" "3" "508" "55.0" "7.06" "7.09" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "Regulation of actin dynamics for phagocytic cup formation; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC2 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle" "EGF/EGFR signaling pathway" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585340363182511889" "False" "High" "IsMasterProtein" "Q9HBU6" "Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1" "0.000" "False" "13.633" "10" "5" "6" "5" "452" "50.9" "6.54" "20.27" "5" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "55500" "ENSG00000139163" "ETNK1" "G5E969; hsa:55500; Q9HBU6" "Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "5" "0" "0.906" "0.861" "0.878" "0.966" "0.910" "0.882" "0.925" "0.872" "0.891" "442.9" "401.2" "381.3" "389.0" "427.7" "403.2" "390.6" "409.5" "386.4" "394.8" "" "" "" "" "" "" "" "" "" "" "399.8" "309.5" "294.9" "262.0" "356.7" "344.1" "331.3" "296.4" "260.6" "394.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8307908846177998742" "False" "High" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "0.000" "False" "13.591" "8" "3" "5" "3" "432" "48.5" "6.54" "14.38" "3" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; Photodynamic therapy-induced AP-1 survival signaling; IL-18 signaling pathway; Acute myeloid leukemia; NF1 copy number variation syndrome" "27" "0" "1.082" "1.145" "1.048" "1.086" "0.843" "1.135" "1.031" "1.107" "0.931" "77.8" "84.2" "89.1" "81.5" "84.5" "65.6" "88.3" "80.2" "86.1" "72.4" "" "" "" "" "" "" "" "" "" "" "70.2" "64.9" "68.9" "54.9" "70.5" "56.0" "74.9" "58.1" "58.1" "72.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4946696058487786946" "False" "High" "IsMasterProtein" "Q9UHJ6" "Sedoheptulokinase OS=Homo sapiens OX=9606 GN=SHPK PE=1 SV=4" "0.000" "False" "13.585" "9" "3" "3" "3" "478" "51.5" "6.83" "8.99" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00370" "23729" "ENSG00000197417" "SHPK" "B2R640; Q8WUH3; Q9UHJ6" "Pentose phosphate pathway" "" "1" "0" "1.010" "0.980" "1.160" "1.138" "1.153" "1.058" "1.133" "1.043" "0.917" "105.8" "106.9" "103.7" "122.8" "120.4" "122.0" "112.0" "119.9" "110.4" "97.0" "" "" "" "" "" "" "" "" "" "" "95.5" "82.5" "80.2" "82.7" "100.4" "104.1" "95.0" "86.8" "74.4" "97.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1820553366353762966" "False" "High" "IsMasterProtein" "Q9UKF7" "Cytoplasmic phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNC1 PE=1 SV=3" "0.000" "False" "13.583" "9" "3" "5" "3" "332" "38.4" "6.40" "13.51" "3" "cell organization and biogenesis;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "26207" "ENSG00000154217" "PITPNC1" "A8K473; hsa:26207; J3QR20; Q96I07; Q9UKF7" "" "" "0" "0" "1.268" "1.327" "1.552" "1.240" "1.858" "1.666" "1.290" "1.439" "1.112" "10.5" "13.3" "13.9" "16.3" "13.0" "19.5" "17.5" "13.5" "15.1" "11.7" "" "" "" "" "" "" "" "" "" "" "9.5" "10.2" "10.7" "10.9" "10.8" "16.6" "14.8" "9.8" "10.2" "11.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564377166653415060" "False" "High" "IsMasterProtein" "Q5JS54" "Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2" "0.000" "False" "13.558" "28" "2" "4" "2" "123" "13.8" "6.52" "12.92" "2" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf16093" "389362" "ENSG00000180822" "PSMG4" "C9J2F8; F8WBZ2; hsa:389362; Q5JS53; Q5JS54; Q5JS56" "" "" "0" "0" "1.097" "1.169" "0.685" "1.071" "1.057" "1.004" "0.981" "1.186" "0.853" "69.7" "76.5" "81.6" "47.8" "74.7" "73.7" "70.1" "68.5" "82.7" "59.5" "" "" "" "" "" "" "" "" "" "" "63.0" "59.0" "63.1" "32.2" "62.3" "62.9" "59.4" "49.5" "55.8" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6951101032549152638" "False" "High" "IsMasterProtein" "Q9BYD3" "Large ribosomal subunit protein uL4m OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1" "0.000" "False" "13.553" "8" "2" "3" "2" "311" "34.9" "9.72" "10.86" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00573" "51073" "ENSG00000105364" "MRPL4" "A6NNV7; hsa:51073; Q9BW07; Q9BYD3; Q9H4N2; Q9Y317" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.101" "0.845" "1.105" "1.283" "1.074" "1.026" "1.116" "0.911" "1.046" "56.5" "62.2" "47.7" "62.4" "72.4" "60.6" "57.9" "63.0" "51.4" "59.0" "" "" "" "" "" "" "" "" "" "" "51.0" "48.0" "36.9" "42.0" "60.4" "51.8" "49.2" "45.6" "34.7" "59.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696690186535498755" "False" "High" "IsMasterProtein" "Q9NPJ3" "Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1" "0.000" "False" "13.553" "16" "2" "3" "2" "140" "15.0" "9.14" "10.35" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf03061" "55856" "ENSG00000112304" "ACOT13" "F5H2L4; hsa:55856; O95549; Q9NPJ3" "Mitochondrial Fatty Acid Beta-Oxidation" "" "1" "0" "0.961" "0.920" "0.994" "0.940" "0.954" "0.962" "0.932" "1.029" "0.811" "146.7" "141.0" "135.0" "145.8" "137.9" "139.9" "141.2" "136.8" "150.9" "118.9" "" "" "" "" "" "" "" "" "" "" "132.4" "108.8" "104.4" "98.2" "115.0" "119.4" "119.8" "99.0" "101.8" "118.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877552904475964910" "False" "High" "IsMasterProtein" "Q9NX63" "MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1" "0.000" "False" "13.534" "14" "3" "3" "3" "227" "26.1" "8.28" "9.96" "3" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf05300" "54927" "ENSG00000106554" "CHCHD3" "hsa:54927; Q9NX63" "Cristae formation; Mitochondrial protein import" "" "2" "0" "1.043" "0.944" "0.974" "1.098" "1.045" "0.925" "1.203" "0.946" "0.714" "246.6" "257.3" "232.7" "240.3" "270.7" "257.8" "228.2" "296.8" "233.2" "176.1" "" "" "" "" "" "" "" "" "" "" "222.6" "198.4" "180.0" "161.8" "225.8" "220.0" "193.5" "214.8" "157.3" "176.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7212172965787635527" "False" "High" "IsMasterProtein" "Q15031" "Leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2" "0.000" "False" "13.514" "4" "4" "5" "4" "903" "101.9" "8.22" "15.52" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00133, Pf08264, Pf13603" "23395" "ENSG00000011376" "LARS2" "hsa:23395; Q15031" "Mitochondrial tRNA aminoacylation" "Amino acid metabolism; IL-18 signaling pathway; Primary ovarian insufficiency" "4" "0" "1.020" "0.908" "1.104" "1.087" "1.060" "0.999" "0.871" "0.960" "1.604" "105.8" "107.9" "96.1" "116.8" "115.0" "112.1" "105.7" "92.2" "101.6" "169.7" "" "" "" "" "" "" "" "" "" "" "95.5" "83.2" "74.3" "78.7" "95.9" "95.7" "89.7" "66.7" "68.5" "169.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8194850060938304098" "False" "High" "IsMasterProtein" "Q8N5I9" "NOP protein chaperone 1 OS=Homo sapiens OX=9606 GN=NOPCHAP1 PE=1 SV=2" "0.000" "False" "13.480" "20" "4" "6" "4" "185" "20.1" "5.22" "18.47" "4" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf15370" "121053" "ENSG00000151131" "NOPCHAP1" "Q8N5I9" "" "" "0" "0" "0.983" "0.879" "0.890" "0.919" "0.824" "0.989" "0.985" "0.736" "0.778" "407.3" "400.2" "358.2" "362.4" "374.5" "335.5" "402.7" "401.2" "299.9" "316.8" "" "" "" "" "" "" "" "" "" "" "367.7" "308.7" "277.1" "244.0" "312.4" "286.4" "341.6" "290.3" "202.3" "316.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8603881510889965526" "False" "High" "IsMasterProtein" "Q92889" "DNA repair endonuclease XPF OS=Homo sapiens OX=9606 GN=ERCC4 PE=1 SV=3" "0.000" "False" "13.478" "2" "2" "4" "2" "916" "104.4" "6.93" "13.11" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02732" "2072" "ENSG00000175595" "ERCC4" "A5PKV6; A8K111; hsa:2072; O00140; Q8TD83; Q92889" "HDR through Single Strand Annealing (SSA); Fanconi Anemia Pathway; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "0.993" "0.972" "1.158" "1.045" "0.889" "1.102" "0.978" "1.024" "2.094" "398.0" "395.1" "387.0" "460.8" "416.0" "353.7" "438.8" "389.4" "407.5" "833.2" "" "" "" "" "" "" "" "" "" "" "359.3" "304.7" "299.3" "310.3" "347.0" "301.9" "372.2" "281.8" "274.9" "833.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8656179388413657305" "False" "High" "IsMasterProtein" "O00308" "NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2" "0.000" "False" "13.430" "3" "2" "2" "2" "870" "98.9" "7.12" "8.05" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00397, Pf00632" "11060" "ENSG00000198373" "WWP2" "A6NEP1; B2R706; B4DTL5; F5H213; H3BRF3; hsa:11060; I3RSG8; O00308; Q6ZTQ5; Q96CZ2; Q9BWN6" "RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle" "" "5" "0" "1.157" "1.887" "1.208" "1.253" "1.714" "1.389" "1.064" "1.919" "3.135" "85.4" "98.9" "161.3" "103.2" "107.1" "146.4" "118.7" "90.9" "163.9" "267.8" "" "" "" "" "" "" "" "" "" "" "77.1" "76.3" "124.7" "69.5" "89.3" "125.0" "100.7" "65.8" "110.6" "267.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7881341601402710105" "False" "High" "IsMasterProtein" "Q8IYQ7" "Threonine synthase-like 1 OS=Homo sapiens OX=9606 GN=THNSL1 PE=1 SV=2" "0.000" "False" "13.416" "3" "2" "3" "2" "743" "83.0" "7.12" "9.29" "2" "" "other cell component" "" "Pf01202, Pf14821" "79896" "ENSG00000185875" "THNSL1" "B3KWL1; D3DRV3; hsa:79896; Q5VV21; Q8IYQ7" "" "" "0" "0" "0.884" "0.671" "1.024" "0.824" "0.851" "0.786" "0.906" "0.695" "0.748" "65.7" "58.1" "44.1" "67.3" "54.1" "56.0" "51.7" "59.5" "45.7" "49.2" "" "" "" "" "" "" "" "" "" "" "59.3" "44.8" "34.1" "45.3" "45.2" "47.8" "43.8" "43.1" "30.8" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1587907933929237870" "False" "High" "IsMasterProtein" "Q02548" "Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1" "0.000" "False" "13.405" "11" "3" "3" "3" "391" "42.1" "9.00" "10.25" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292, Pf12403" "5079" "ENSG00000196092" "PAX5" "A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; hsa:5079; O75933; Q02548; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732" "RUNX1 regulates transcription of genes involved in BCR signaling" "Prion disease pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; ID signaling pathway" "4" "0" "1.136" "1.185" "1.146" "1.197" "1.177" "0.982" "1.219" "1.088" "1.000" "130.0" "147.7" "154.1" "148.9" "155.6" "153.1" "127.7" "158.4" "141.4" "130.0" "" "" "" "" "" "" "" "" "" "" "117.4" "113.9" "119.2" "100.3" "129.8" "130.7" "108.3" "114.7" "95.4" "130.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225223608593832705" "False" "High" "IsMasterProtein" "Q99856" "AT-rich interactive domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ARID3A PE=1 SV=2" "0.000" "False" "13.384" "8" "4" "4" "4" "593" "62.9" "4.91" "11.83" "4" "other biological processes" "other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01388" "1820" "ENSG00000116017" "ARID3A" "hsa:1820; Q5I858; Q6P9C6; Q8IZA7; Q8N4Z3; Q99856" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" "HDAC6 interactions in the central nervous system" "2" "0" "0.920" "1.052" "1.138" "0.878" "1.153" "0.989" "0.564" "0.963" "6.482" "112.5" "103.4" "118.3" "128.0" "98.7" "129.6" "111.2" "63.5" "108.2" "728.9" "" "" "" "" "" "" "" "" "" "" "101.5" "79.8" "91.5" "86.2" "82.4" "110.6" "94.4" "45.9" "73.0" "728.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029277553794243506" "False" "High" "IsMasterProtein" "P61244" "Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1" "0.000" "False" "13.357" "21" "4" "4" "4" "160" "18.3" "6.30" "13.50" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4149" "ENSG00000125952" "MAX" "A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8" "Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation" "11" "0" "0.991" "0.923" "0.931" "0.949" "0.996" "0.982" "1.053" "0.965" "0.713" "461.4" "457.1" "425.8" "429.6" "437.9" "459.3" "453.1" "485.9" "445.3" "328.8" "" "" "" "" "" "" "" "" "" "" "416.5" "352.6" "329.4" "289.3" "365.3" "392.0" "384.4" "351.6" "300.3" "328.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7953357218888963531" "False" "High" "IsMasterProtein" "Q3KQU3" "MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1" "0.000" "False" "13.355" "7" "5" "7" "5" "841" "92.8" "10.11" "16.59" "5" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf05672" "55700" "ENSG00000116871" "MAP7D1" "D3DPS4; hsa:55700; Q3KQU3; Q7L8J5; Q8N905; Q8TAK0; Q9HBQ2; Q9NW29; Q9ULN3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8399686422006739058" "False" "High" "IsMasterProtein" "O15116" "U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1" "0.000" "False" "13.353" "30" "3" "3" "3" "133" "15.2" "5.22" "9.03" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27257" "ENSG00000175324" "LSM1" "B2R5E6; hsa:27257; O15116" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "1.069" "0.981" "1.192" "0.824" "1.116" "1.001" "0.950" "0.864" "0.605" "43.7" "46.7" "42.9" "52.1" "36.0" "48.8" "43.7" "41.5" "37.8" "26.5" "" "" "" "" "" "" "" "" "" "" "39.4" "36.1" "33.2" "35.1" "30.1" "41.6" "37.1" "30.0" "25.5" "26.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3430961605673792526" "False" "High" "IsMasterProtein" "Q13033" "Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3" "0.000" "False" "13.348" "4" "3" "3" "3" "797" "87.2" "5.36" "10.01" "3" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400, Pf08232" "29966" "ENSG00000196792" "STRN3" "A2RTX7; A6NHZ7; hsa:29966; Q13033; Q9NRA5" "" "" "0" "0" "1.172" "1.261" "1.065" "1.347" "1.359" "1.107" "1.091" "1.751" "0.951" "33.3" "39.0" "42.0" "35.5" "44.9" "45.3" "36.9" "36.4" "58.3" "31.7" "" "" "" "" "" "" "" "" "" "" "30.1" "30.1" "32.5" "23.9" "37.4" "38.6" "31.3" "26.3" "39.3" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832536973652725080" "False" "High" "IsMasterProtein" "Q96C90" "Protein phosphatase 1 regulatory subunit 14B OS=Homo sapiens OX=9606 GN=PPP1R14B PE=1 SV=3" "0.000" "False" "13.336" "16" "1" "3" "1" "147" "15.9" "4.86" "13.21" "1" "stress response;other biological processes" "other cell component" "enzyme regulator activity" "Pf05361" "26472" "ENSG00000173457" "PPP1R14B" "hsa:26472; Q504S7; Q7KZD7; Q96C90" "" "" "0" "0" "1.286" "1.254" "1.450" "1.148" "1.034" "1.245" "1.260" "1.221" "0.987" "21.4" "27.6" "26.9" "31.1" "24.6" "22.2" "26.7" "27.0" "26.2" "21.1" "" "" "" "" "" "" "" "" "" "" "19.3" "21.3" "20.8" "20.9" "20.5" "18.9" "22.6" "19.5" "17.6" "21.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1171297253546326275" "False" "High" "IsMasterProtein" "Q6AI08" "HEAT repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=HEATR6 PE=1 SV=1" "0.000" "False" "13.313" "3" "3" "3" "2" "1181" "128.7" "7.03" "10.26" "3" "" "" "" "Pf13251" "63897" "ENSG00000068097" "HEATR6" "B3KXP3; hsa:63897; Q6AI08; Q6MZX1; Q6MZY2; Q8TDM9; Q9H6B3; Q9H6M7" "" "" "0" "0" "1.308" "1.116" "1.229" "1.315" "0.951" "0.885" "1.308" "1.087" "2.549" "10.1" "13.2" "11.3" "12.4" "13.3" "9.6" "9.0" "13.2" "11.0" "25.8" "" "" "" "" "" "" "" "" "" "" "9.1" "10.2" "8.7" "8.4" "11.1" "8.2" "7.6" "9.6" "7.4" "25.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845419377566949929" "False" "High" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "0.000" "False" "13.307" "12" "2" "3" "1" "147" "16.7" "7.80" "10.58" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Peroxisomal protein import; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; E3 ubiquitin ligases ubiquitinate target proteins; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "Proteasome degradation" "13" "1" "0.936" "0.836" "0.997" "0.900" "0.882" "0.862" "0.926" "0.785" "1.019" "277.0" "259.4" "231.7" "276.1" "249.2" "244.2" "238.8" "256.6" "217.5" "282.2" "" "" "" "" "" "" "" "" "" "" "250.1" "200.1" "179.2" "185.9" "207.9" "208.4" "202.6" "185.7" "146.7" "282.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4125655909395712746" "False" "High" "IsMasterProtein" "Q8IUR7" "Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2" "0.000" "False" "13.307" "6" "3" "3" "3" "673" "75.5" "6.73" "9.77" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00514" "25852" "ENSG00000114098" "ARMC8" "A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; hsa:25852; Q6PIL2; Q8IUR7; Q96D19; Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9" "Neutrophil degranulation" "Ciliary landscape" "2" "0" "1.041" "0.807" "1.021" "0.873" "0.811" "1.066" "1.016" "0.896" "1.040" "109.8" "114.3" "88.6" "112.1" "95.9" "89.0" "117.1" "111.6" "98.4" "114.2" "" "" "" "" "" "" "" "" "" "" "99.1" "88.2" "68.5" "75.5" "80.0" "76.0" "99.4" "80.7" "66.4" "114.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3862869163996360692" "False" "High" "IsMasterProtein" "Q7LBR1" "Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1" "0.000" "False" "13.303" "16" "4" "5" "4" "199" "22.1" "8.10" "12.34" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "57132" "ENSG00000255112" "CHMP1B" "hsa:57132; Q7LBR1; Q96E89; Q9HD41" "" "" "0" "0" "1.038" "1.071" "1.187" "0.999" "1.082" "1.052" "1.086" "1.095" "1.000" "462.6" "480.3" "495.3" "549.0" "461.9" "500.5" "486.7" "502.3" "506.6" "462.6" "" "" "" "" "" "" "" "" "" "" "417.6" "370.5" "383.1" "369.7" "385.3" "427.2" "412.9" "363.5" "341.7" "462.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964659957025433859" "False" "High" "IsMasterProtein" "Q9H2H8" "Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1" "0.000" "False" "13.297" "21" "3" "4" "3" "161" "18.1" "6.79" "9.52" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160" "53938" "ENSG00000240344" "PPIL3" "hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.133" "0.839" "1.347" "0.932" "0.850" "1.149" "0.998" "1.099" "2.920" "35.2" "39.9" "29.6" "47.5" "32.9" "30.0" "40.5" "35.2" "38.7" "102.9" "" "" "" "" "" "" "" "" "" "" "31.8" "30.8" "22.9" "32.0" "27.4" "25.6" "34.4" "25.5" "26.1" "102.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7695782687359326445" "False" "High" "IsMasterProtein" "Q13342" "Nuclear body protein SP140 OS=Homo sapiens OX=9606 GN=SP140 PE=1 SV=2" "0.000" "False" "13.297" "7" "4" "4" "4" "867" "98.2" "5.27" "13.68" "4" "stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf01342, Pf03172" "11262" "ENSG00000079263" "SP140" "E7ESH9; E7EUR5; E9PFJ6; hsa:11262; Q0VGE5; Q13341; Q13342; Q3KR17; Q4ZG66; Q53TG1; Q6NSG4; Q92881; Q96TG3" "" "" "0" "0" "1.029" "1.892" "1.140" "1.080" "1.878" "1.013" "1.061" "1.919" "2.025" "202.4" "208.2" "383.0" "230.8" "218.5" "380.2" "205.1" "214.8" "388.4" "409.9" "" "" "" "" "" "" "" "" "" "" "182.7" "160.6" "296.2" "155.4" "182.3" "324.5" "174.0" "155.5" "262.0" "409.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479259144489451223" "False" "High" "IsMasterProtein" "Q96DG6" "Carboxymethylenebutenolidase homolog OS=Homo sapiens OX=9606 GN=CMBL PE=1 SV=1" "0.000" "False" "13.292" "13" "4" "5" "4" "245" "28.0" "7.18" "12.75" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf01738" "134147" "ENSG00000164237" "CMBL" "D3DTC7; hsa:134147; Q8TED6; Q96DG6" "Phase I - Functionalization of compounds" "" "1" "0" "0.981" "1.029" "1.001" "1.026" "1.015" "0.983" "1.042" "1.061" "0.969" "390.2" "382.5" "401.4" "390.7" "400.2" "395.8" "383.6" "406.4" "414.0" "378.1" "" "" "" "" "" "" "" "" "" "" "352.2" "295.1" "310.4" "263.1" "333.9" "337.9" "325.4" "294.1" "279.2" "378.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9211506236520866705" "False" "High" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "0.000" "False" "13.289" "11" "4" "7" "4" "339" "37.8" "4.97" "18.86" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "Cytosolic iron-sulfur cluster assembly" "2q11.2 copy number variation syndrome" "2" "0" "1.156" "1.108" "1.187" "1.106" "1.035" "1.242" "1.082" "1.039" "0.920" "273.6" "316.2" "303.2" "324.6" "302.6" "283.1" "339.8" "296.0" "284.3" "251.6" "" "" "" "" "" "" "" "" "" "" "246.9" "243.9" "234.5" "218.6" "252.4" "241.6" "288.3" "214.2" "191.8" "251.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3075207303668690710" "False" "High" "IsMasterProtein" "P37198" "Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3" "0.000" "False" "13.276" "5" "2" "2" "2" "522" "53.2" "5.31" "8.91" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05064" "23636" "ENSG00000213024" "NUP62" "B3KWU5; hsa:23636; P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1" "HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "7q11.23 copy number variation syndrome" "30" "0" "0.944" "0.809" "1.026" "0.912" "0.801" "0.925" "0.841" "0.754" "1.124" "119.7" "112.9" "96.9" "122.8" "109.2" "95.8" "110.7" "100.6" "90.2" "134.5" "" "" "" "" "" "" "" "" "" "" "108.0" "87.1" "74.9" "82.7" "91.1" "81.8" "93.9" "72.8" "60.8" "134.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084161266970488512" "False" "High" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "0.000" "False" "13.258" "10" "5" "5" "5" "551" "60.2" "5.68" "12.78" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Transcriptional regulation of white adipocyte differentiation; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Selenium metabolism and selenoproteins; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 15q11q13 copy number variation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "101" "0" "0.683" "0.834" "0.836" "0.922" "0.916" "0.980" "0.905" "0.884" "4.023" "31.5" "21.5" "26.2" "26.3" "29.0" "28.8" "30.8" "28.5" "27.8" "126.6" "" "" "" "" "" "" "" "" "" "" "28.4" "16.6" "20.3" "17.7" "24.2" "24.6" "26.2" "20.6" "18.8" "126.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93138434393619496" "False" "High" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "0.000" "False" "13.257" "3" "4" "4" "2" "1447" "164.6" "8.47" "14.31" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "0" "0.944" "1.284" "1.014" "0.713" "1.276" "0.706" "0.696" "1.140" "1.877" "20.7" "19.6" "26.6" "21.0" "14.8" "26.4" "14.6" "14.4" "23.6" "38.9" "" "" "" "" "" "" "" "" "" "" "18.7" "15.1" "20.6" "14.2" "12.3" "22.6" "12.4" "10.4" "15.9" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1141422113329583141" "False" "High" "IsMasterProtein" "Q04446" "1,4-alpha-glucan-branching enzyme OS=Homo sapiens OX=9606 GN=GBE1 PE=1 SV=3" "0.000" "False" "13.249" "5" "3" "4" "3" "702" "80.4" "6.32" "14.07" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00128, Pf02806, Pf02922" "2632" "ENSG00000114480" "GBE1" "B3KWV3; hsa:2632; Q04446; Q96EN0" "Glycogen synthesis; Glycogen storage disease type IV (GBE1)" "Glycogen synthesis and degradation; Disorders of galactose metabolism" "4" "0" "0.915" "1.071" "1.213" "0.914" "1.028" "0.912" "1.060" "1.040" "2.095" "105.6" "96.6" "113.0" "128.1" "96.5" "108.6" "96.3" "111.9" "109.8" "221.1" "" "" "" "" "" "" "" "" "" "" "95.3" "74.5" "87.4" "86.3" "80.5" "92.7" "81.7" "81.0" "74.1" "221.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3084200639085863850" "False" "High" "IsMasterProtein" "O14497" "AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3" "0.000" "False" "13.249" "1" "2" "2" "2" "2285" "241.9" "6.70" "7.86" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "8289" "ENSG00000117713" "ARID1A" "D3DPL1; hsa:8289; O14497; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "7" "0" "1.137" "1.363" "1.222" "1.319" "1.565" "1.170" "0.968" "1.322" "2.091" "70.7" "80.5" "96.4" "86.4" "93.3" "110.7" "82.8" "68.5" "93.6" "147.9" "" "" "" "" "" "" "" "" "" "" "63.9" "62.1" "74.6" "58.2" "77.9" "94.5" "70.2" "49.6" "63.1" "147.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830311805247258078" "False" "High" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "0.000" "False" "13.248" "14" "4" "5" "4" "245" "26.4" "6.52" "14.64" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "Ciliary landscape" "7" "0" "1.095" "1.196" "1.009" "0.766" "0.960" "0.853" "1.088" "0.896" "0.699" "129.0" "141.3" "154.3" "130.1" "98.8" "123.8" "110.0" "140.3" "115.6" "90.2" "" "" "" "" "" "" "" "" "" "" "116.4" "109.0" "119.4" "87.6" "82.4" "105.6" "93.3" "101.5" "78.0" "90.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7460825629413537855" "False" "High" "IsMasterProtein" "Q9BV40" "Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1" "0.000" "False" "13.239" "18" "2" "4" "2" "100" "11.4" "7.34" "12.61" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "8673" "ENSG00000118640" "VAMP8" "hsa:8673; O60625; Q53SP9; Q6IB09; Q9BV40" "Neutrophil degranulation; ER-Phagosome pathway; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "8" "0" "1.091" "1.009" "0.971" "1.216" "1.097" "0.971" "1.315" "0.937" "0.910" "57.9" "63.2" "58.5" "56.2" "70.4" "63.5" "56.2" "76.2" "54.3" "52.7" "" "" "" "" "" "" "" "" "" "" "52.3" "48.8" "45.2" "37.9" "58.7" "54.2" "47.7" "55.1" "36.6" "52.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088025864314276117" "False" "High" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "0.000" "False" "13.238" "6" "3" "3" "3" "577" "63.1" "9.44" "10.54" "3" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "0" "0.985" "0.876" "0.783" "1.089" "0.903" "1.086" "1.083" "0.910" "0.825" "102.6" "101.0" "89.8" "80.3" "111.7" "92.6" "111.4" "111.1" "93.3" "84.6" "" "" "" "" "" "" "" "" "" "" "92.6" "77.9" "69.5" "54.1" "93.2" "79.1" "94.5" "80.4" "62.9" "84.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-273580326344755001" "False" "High" "IsMasterProtein" "P26885" "Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2" "0.000" "False" "13.234" "23" "3" "4" "3" "142" "15.6" "9.13" "9.00" "3" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00254" "2286" "ENSG00000173486" "FKBP2" "hsa:2286; P26885; Q5BJH9; Q9BTS7" "" "Complement system" "1" "0" "1.431" "1.322" "1.272" "1.260" "1.271" "1.211" "1.019" "1.315" "0.734" "129.7" "185.6" "171.5" "165.0" "163.4" "164.9" "157.1" "132.1" "170.6" "95.2" "" "" "" "" "" "" "" "" "" "" "117.1" "143.2" "132.7" "111.1" "136.3" "140.7" "133.3" "95.6" "115.1" "95.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517606527837170781" "False" "High" "IsMasterProtein" "Q9Y5P6" "Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2" "0.000" "False" "13.204" "6" "2" "4" "2" "360" "39.8" "6.61" "10.21" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29925" "ENSG00000173540" "GMPPB" "A8K6N5; hsa:29925; Q9H7U3; Q9Y5P6" "Synthesis of GDP-mannose" "N-glycan biosynthesis" "2" "0" "1.010" "0.950" "0.987" "0.973" "1.047" "1.031" "0.953" "1.019" "0.781" "215.0" "217.1" "204.3" "212.1" "209.2" "225.1" "221.7" "204.9" "219.0" "168.0" "" "" "" "" "" "" "" "" "" "" "194.0" "167.5" "158.0" "142.8" "174.5" "192.1" "188.0" "148.3" "147.7" "168.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990414283188081585" "False" "High" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "0.000" "False" "13.198" "8" "5" "5" "5" "514" "57.2" "9.17" "15.08" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "mRNA Splicing - Major Pathway" "" "1" "0" "0.931" "1.251" "1.066" "0.986" "1.436" "1.002" "1.023" "1.438" "0.853" "378.3" "352.3" "473.1" "403.3" "372.8" "543.4" "378.9" "386.8" "544.1" "322.7" "" "" "" "" "" "" "" "" "" "" "341.5" "271.8" "365.9" "271.6" "311.0" "463.8" "321.4" "279.9" "367.0" "322.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308082143838358470" "False" "High" "IsMasterProtein" "P42766" "Large ribosomal subunit protein uL29 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "0.000" "False" "13.159" "20" "3" "4" "3" "123" "14.5" "11.05" "14.00" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.959" "1.318" "1.047" "1.267" "1.181" "1.223" "1.152" "1.196" "0.403" "455.8" "437.2" "600.7" "477.4" "577.5" "538.1" "557.7" "525.1" "545.1" "183.6" "" "" "" "" "" "" "" "" "" "" "411.5" "337.2" "464.6" "321.5" "481.7" "459.3" "473.1" "380.0" "367.7" "183.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6950244637905263726" "False" "High" "IsMasterProtein" "Q9Y3B4" "Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1" "0.000" "False" "13.150" "39" "4" "4" "4" "125" "14.6" "9.38" "11.91" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00076" "51639" "ENSG00000115128" "SF3B6" "hsa:51639; Q53TM1; Q9Y3B4" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "0.878" "0.829" "0.856" "0.861" "0.897" "0.789" "0.811" "0.775" "1.023" "162.5" "142.7" "134.7" "139.1" "139.8" "145.7" "128.1" "131.8" "126.0" "166.2" "" "" "" "" "" "" "" "" "" "" "146.7" "110.1" "104.2" "93.7" "116.6" "124.4" "108.7" "95.4" "85.0" "166.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6592618097650740774" "False" "High" "IsMasterProtein" "Q9UDY2" "Tight junction protein ZO-2 OS=Homo sapiens OX=9606 GN=TJP2 PE=1 SV=2" "0.000" "False" "13.141" "2" "3" "3" "3" "1190" "133.9" "7.40" "7.45" "3" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00595, Pf00625, Pf07653" "9414" "ENSG00000119139" "TJP2" "A2A3H9; B7Z2R8; B7Z7T6; F5H301; F5H886; hsa:9414; Q15883; Q5VXL0; Q5VXL1; Q8N756; Q8NI14; Q99839; Q9UDY0; Q9UDY1; Q9UDY2" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Signaling by Hippo; Apoptotic cleavage of cell adhesion proteins" "1q21.1 copy number variation syndrome; 15q11q13 copy number variation" "7" "0" "0.890" "2.603" "0.954" "1.393" "2.303" "1.354" "1.703" "2.331" "2.623" "81.4" "72.4" "211.9" "77.6" "113.4" "187.5" "110.2" "138.6" "189.7" "213.4" "" "" "" "" "" "" "" "" "" "" "73.5" "55.9" "163.9" "52.3" "94.6" "160.0" "93.5" "100.3" "127.9" "213.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7107318601171383488" "False" "High" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "0.000" "False" "13.133" "15" "3" "5" "3" "167" "19.4" "7.40" "14.61" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "1.114" "1.094" "1.103" "0.998" "1.186" "1.121" "1.243" "1.209" "0.840" "132.2" "147.3" "144.7" "145.8" "132.0" "156.9" "148.3" "164.4" "159.9" "111.1" "" "" "" "" "" "" "" "" "" "" "119.4" "113.6" "111.9" "98.2" "110.1" "133.9" "125.8" "119.0" "107.9" "111.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4306036841848923980" "False" "High" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "0.000" "False" "13.110" "11" "5" "6" "4" "370" "40.7" "7.21" "18.90" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "ESR-mediated signaling" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "4" "0" "1.071" "0.875" "1.007" "0.790" "0.978" "1.094" "0.584" "1.102" "5.977" "45.9" "49.2" "40.2" "46.2" "36.3" "44.9" "50.2" "26.8" "50.6" "274.5" "" "" "" "" "" "" "" "" "" "" "41.5" "37.9" "31.1" "31.1" "30.3" "38.3" "42.6" "19.4" "34.1" "274.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7158651141849584646" "False" "High" "IsMasterProtein" "Q9Y294" "Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1" "0.000" "False" "13.110" "24" "3" "5" "3" "204" "23.0" "4.41" "11.27" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04729" "25842" "ENSG00000111875" "ASF1A" "hsa:25842; Q6IA08; Q9P014; Q9Y294" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "22q11.2 copy number variation syndrome" "2" "0" "1.058" "0.863" "1.085" "1.011" "0.918" "0.976" "0.971" "1.015" "1.344" "162.6" "172.1" "140.3" "176.5" "164.4" "149.3" "158.8" "158.0" "165.1" "218.6" "" "" "" "" "" "" "" "" "" "" "146.8" "132.7" "108.5" "118.8" "137.1" "127.4" "134.7" "114.3" "111.4" "218.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9155703229501675198" "False" "High" "IsMasterProtein" "P31751" "RAC-beta serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT2 PE=1 SV=2" "0.000" "False" "13.098" "9" "3" "3" "3" "481" "55.7" "6.37" "9.02" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "208" "ENSG00000105221" "AKT2" "B2RBD8; hsa:208; P31751; Q05BV0; Q0VAN0; Q0VAN1; Q68GC0" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; Activation of AKT2; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; RAB GEFs exchange GTP for GDP on RABs; CTLA4 inhibitory signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; AKT phosphorylates targets in the nucleus; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Downregulation of ERBB2:ERBB3 signaling; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; FLT3 Signaling; Negative regulation of the PI3K/AKT network; Regulation of TP53 Activity through Acetylation; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; PDE3B signalling; Inhibition of TSC complex formation by PKB" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; S1P receptor signal transduction; Cardiac hypertrophic response; Focal adhesion; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Acute myeloid leukemia; Sildenafil treatment; Female steroid hormones in cardiomyocyte energy metabolism; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; Artemisinin inhibition of uveal melanoma; ErbB signaling pathway; Toll-like receptor signaling pathway" "83" "0" "1.085" "1.213" "0.981" "1.132" "1.092" "1.077" "0.914" "0.990" "1.568" "40.4" "43.8" "49.0" "39.6" "45.7" "44.1" "43.5" "36.9" "40.0" "63.4" "" "" "" "" "" "" "" "" "" "" "36.5" "33.8" "37.9" "26.7" "38.2" "37.7" "36.9" "26.7" "27.0" "63.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3443446084982214279" "False" "High" "IsMasterProtein" "Q9UN37" "Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1" "0.000" "False" "13.071" "9" "5" "7" "4" "437" "48.9" "7.80" "18.24" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "27183" "ENSG00000132612" "VPS4A" "B2RCB7; hsa:27183; Q8TF07; Q9UI03; Q9UN37; Q9Y582" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III" "Ebola virus infection in host; Ciliary landscape" "6" "0" "1.091" "0.933" "0.984" "1.109" "0.997" "1.103" "1.039" "1.003" "1.665" "328.5" "358.4" "306.5" "323.2" "364.3" "327.4" "362.4" "341.3" "329.6" "547.0" "" "" "" "" "" "" "" "" "" "" "296.5" "276.5" "237.1" "217.7" "303.9" "279.5" "307.4" "247.0" "222.3" "547.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-720179637671099041" "False" "High" "IsMasterProtein" "Q06546" "GA-binding protein alpha chain OS=Homo sapiens OX=9606 GN=GABPA PE=1 SV=1" "0.000" "False" "13.054" "6" "3" "4" "3" "454" "51.3" "4.97" "12.65" "3" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf11620" "2551" "ENSG00000154727" "GABPA" "hsa:2551; Q06546; Q12939" "Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Pleural mesothelioma" "7" "0" "0.949" "1.014" "0.929" "0.865" "1.042" "0.902" "0.915" "1.092" "2.354" "132.9" "126.1" "134.8" "123.5" "114.9" "138.5" "119.9" "121.6" "145.1" "312.8" "" "" "" "" "" "" "" "" "" "" "119.9" "97.3" "104.2" "83.1" "95.8" "118.2" "101.7" "88.0" "97.9" "312.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334840059881177708" "False" "High" "IsMasterProtein" "Q16864" "V-type proton ATPase subunit F OS=Homo sapiens OX=9606 GN=ATP6V1F PE=1 SV=2" "0.000" "False" "13.009" "17" "2" "4" "2" "119" "13.4" "5.52" "14.15" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity" "Pf01990" "9296" "ENSG00000128524" "ATP6V1F" "C9J2K4; hsa:9296; Q16864; Q6IBA8" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "Proximal tubule transport" "6" "0" "1.029" "1.032" "0.945" "1.056" "1.066" "1.049" "1.097" "1.021" "0.842" "245.3" "252.4" "253.0" "231.8" "259.1" "261.5" "257.3" "269.0" "250.4" "206.6" "" "" "" "" "" "" "" "" "" "" "221.4" "194.7" "195.7" "156.1" "216.2" "223.2" "218.2" "194.7" "168.9" "206.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1344142120960836563" "False" "High" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "0.000" "False" "13.000" "5" "2" "3" "2" "393" "44.9" "8.63" "8.93" "2" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "Platelet degranulation" "" "1" "0" "1.186" "1.208" "1.185" "0.969" "1.216" "1.054" "1.034" "0.978" "1.496" "56.8" "67.4" "68.6" "67.3" "55.0" "69.1" "59.9" "58.7" "55.6" "84.9" "" "" "" "" "" "" "" "" "" "" "51.3" "52.0" "53.1" "45.3" "45.9" "59.0" "50.8" "42.5" "37.5" "84.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-569299239056590327" "False" "High" "IsMasterProtein" "Q9Y4F9" "Rho family-interacting cell polarization regulator 2 OS=Homo sapiens OX=9606 GN=RIPOR2 PE=1 SV=4" "0.000" "False" "12.981" "3" "3" "3" "3" "1068" "118.4" "5.41" "9.92" "3" "cell adhesion;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf15903" "9750" "ENSG00000111913" "RIPOR2" "A6NHP2; hsa:9750; Q13529; Q5VV37; Q5VV38; Q9BQ28; Q9Y4F9" "Sensory processing of sound by outer hair cells of the cochlea; Sensory processing of sound by inner hair cells of the cochlea" "" "2" "0" "0.983" "0.925" "1.149" "0.999" "0.812" "1.043" "1.040" "0.908" "1.036" "153.9" "151.2" "142.4" "176.8" "153.7" "125.0" "160.4" "160.0" "139.8" "159.4" "" "" "" "" "" "" "" "" "" "" "138.9" "116.6" "110.1" "119.1" "128.2" "106.7" "136.1" "115.8" "94.3" "159.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7820543804174258540" "False" "High" "IsMasterProtein" "P00374" "Dihydrofolate reductase OS=Homo sapiens OX=9606 GN=DHFR PE=1 SV=2" "0.000" "False" "12.967" "21" "4" "5" "4" "187" "21.4" "7.42" "14.16" "4" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00186" "1719" "ENSG00000228716" "DHFR" "B4DDD2; hsa:1719; P00374; Q14130; Q6IRW8" "G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; Ethanol effects on histone modifications" "9" "0" "0.942" "0.660" "1.030" "1.002" "0.750" "0.920" "0.742" "0.703" "4.253" "258.8" "243.8" "170.7" "266.6" "259.2" "194.0" "238.0" "192.1" "181.9" "1100.8" "" "" "" "" "" "" "" "" "" "" "233.6" "188.1" "132.0" "179.5" "216.3" "165.6" "201.9" "139.0" "122.7" "1100.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "587629030482776779" "False" "High" "IsMasterProtein" "Q5VZM2" "Ras-related GTP-binding protein B OS=Homo sapiens OX=9606 GN=RRAGB PE=1 SV=1" "0.000" "False" "12.923" "8" "3" "4" "3" "374" "43.2" "6.21" "8.03" "3" "stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "10325" "ENSG00000083750" "RRAGB" "A8K042; hsa:10325; Q15348; Q5VZM2; Q8N3T0" "Macroautophagy; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK" "Target of rapamycin signaling; 2q37 copy number variation syndrome" "9" "0" "1.161" "0.945" "1.227" "1.119" "0.997" "1.095" "1.083" "1.015" "0.714" "216.2" "251.0" "204.3" "265.1" "241.8" "215.6" "236.7" "234.2" "219.4" "154.3" "" "" "" "" "" "" "" "" "" "" "195.1" "193.6" "158.0" "178.5" "201.7" "184.0" "200.8" "169.5" "148.0" "154.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3948795116760064813" "False" "High" "IsMasterProtein" "Q7Z2Z2" "Elongation factor-like GTPase 1 OS=Homo sapiens OX=9606 GN=EFL1 PE=1 SV=2" "0.000" "False" "12.912" "3" "4" "6" "4" "1120" "125.4" "5.91" "13.93" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf14492" "79631" "ENSG00000140598" "EFL1" "A6NKY5; B7Z6I0; hsa:79631; Q7Z2Z2; Q9H8Z6" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "1.068" "0.832" "1.006" "1.045" "0.908" "1.024" "1.076" "1.052" "2.016" "126.8" "135.4" "105.5" "127.5" "132.5" "115.1" "129.8" "136.4" "133.4" "255.6" "" "" "" "" "" "" "" "" "" "" "114.4" "104.4" "81.6" "85.9" "110.5" "98.2" "110.1" "98.7" "90.0" "255.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716133539155154712" "False" "High" "IsMasterProtein" "P82650" "Small ribosomal subunit protein mS22 OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" "0.000" "False" "12.906" "9" "3" "4" "3" "360" "41.3" "7.90" "13.45" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10245" "56945" "ENSG00000175110" "MRPS22" "hsa:56945; P82650; Q9H3I1" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "Primary ovarian insufficiency" "4" "0" "0.974" "0.824" "1.019" "0.984" "0.772" "0.937" "0.909" "0.821" "1.354" "277.0" "269.7" "228.2" "282.2" "272.6" "213.8" "259.6" "251.8" "227.3" "375.1" "" "" "" "" "" "" "" "" "" "" "250.0" "208.0" "176.5" "190.1" "227.4" "182.5" "220.2" "182.2" "153.3" "375.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7099090004337322375" "False" "High" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "0.000" "False" "12.891" "37" "2" "2" "1" "89" "10.4" "7.40" "8.00" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "MHC class II antigen presentation; COPI-mediated anterograde transport; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "28" "0" "1.267" "1.346" "1.315" "1.195" "0.890" "1.105" "0.852" "0.883" "1.131" "17.0" "21.5" "22.8" "22.3" "20.3" "15.1" "18.7" "14.4" "15.0" "19.2" "" "" "" "" "" "" "" "" "" "" "15.3" "16.6" "17.6" "15.0" "16.9" "12.9" "15.9" "10.4" "10.1" "19.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8668239743978999828" "False" "High" "IsMasterProtein" "Q9NSI2" "Ribosome biogenesis protein SLX9 homolog OS=Homo sapiens OX=9606 GN=SLX9 PE=1 SV=2" "0.000" "False" "12.882" "13" "3" "3" "3" "230" "25.4" "11.08" "10.87" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf15341" "85395" "ENSG00000160256" "SLX9" "hsa:85395; Q9NSI2" "" "" "0" "0" "1.023" "0.968" "1.145" "1.117" "1.143" "1.097" "0.880" "1.113" "2.623" "77.8" "79.6" "75.3" "89.1" "86.9" "89.0" "85.3" "68.5" "86.6" "204.1" "" "" "" "" "" "" "" "" "" "" "70.2" "61.4" "58.2" "60.0" "72.5" "75.9" "72.4" "49.6" "58.4" "204.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7220611050320335909" "False" "High" "IsMasterProtein" "Q8TDH9" "Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Homo sapiens OX=9606 GN=BLOC1S5 PE=1 SV=1" "0.000" "False" "12.880" "14" "3" "4" "3" "187" "21.6" "7.59" "12.24" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "ER/Golgi;other cell component" "" "Pf14942" "63915" "ENSG00000188428" "BLOC1S5" "B4DVM2; hsa:63915; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q8TDH9; Q9NU16" "" "" "0" "0" "1.045" "0.943" "1.021" "1.021" "1.037" "0.794" "1.054" "0.955" "0.792" "85.2" "89.0" "80.3" "86.9" "87.0" "88.3" "67.6" "89.7" "81.4" "67.5" "" "" "" "" "" "" "" "" "" "" "76.9" "68.6" "62.1" "58.5" "72.6" "75.4" "57.4" "64.9" "54.9" "67.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8333462526308289964" "False" "High" "IsMasterProtein" "O60671" "Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1" "0.000" "False" "12.873" "14" "5" "5" "5" "282" "31.8" "4.83" "15.75" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02144" "5810" "ENSG00000113456" "RAD1" "hsa:5810; O60671; O75572; O95304; Q1W161; Q5KSM0; Q5KSM1; Q9UEP1" "Presynaptic phase of homologous DNA pairing and strand exchange; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "10" "0" "0.887" "1.033" "0.932" "0.911" "0.878" "0.944" "0.973" "0.859" "0.818" "423.4" "375.8" "437.5" "394.5" "385.6" "371.7" "399.8" "411.9" "363.7" "346.5" "" "" "" "" "" "" "" "" "" "" "382.2" "289.8" "338.4" "265.6" "321.7" "317.3" "339.1" "298.1" "245.3" "346.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "715968340642640214" "False" "High" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "0.000" "False" "12.872" "6" "4" "4" "4" "602" "68.2" "6.43" "12.61" "4" "signal transduction" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "0.912" "0.937" "0.999" "0.856" "0.974" "0.955" "0.881" "0.979" "2.361" "268.4" "244.8" "251.5" "268.0" "229.6" "261.4" "256.3" "236.3" "262.8" "633.5" "" "" "" "" "" "" "" "" "" "" "242.3" "188.8" "194.5" "180.5" "191.5" "223.1" "217.4" "171.0" "177.3" "633.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3369137616140023088" "False" "High" "IsMasterProtein" "Q9NZJ9" "Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2" "0.000" "False" "12.866" "17" "3" "3" "2" "180" "20.3" "6.35" "10.96" "3" "other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000173598" "NUDT4" "B7Z916; hsa:11163; Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZJ9; Q9NZK0; Q9NZK1" "Synthesis of pyrophosphates in the cytosol" "" "1" "0" "0.900" "0.857" "0.999" "0.913" "0.851" "0.864" "0.757" "0.911" "2.530" "204.2" "183.8" "175.0" "204.0" "186.5" "173.9" "176.4" "154.6" "186.1" "516.6" "" "" "" "" "" "" "" "" "" "" "184.3" "141.8" "135.3" "137.4" "155.6" "148.4" "149.6" "111.9" "125.5" "516.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5616510837335031809" "False" "High" "IsMasterProtein" "P15586" "N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3" "0.000" "False" "12.854" "5" "3" "3" "3" "552" "62.0" "8.31" "10.14" "3" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "2799" "ENSG00000135677" "GNS" "B4DYH8; hsa:2799; P15586; Q53F05" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Keratan sulfate degradation; MPS IIID - Sanfilippo syndrome D" "Glycosaminoglycan degradation" "5" "0" "1.068" "1.273" "1.098" "1.037" "1.250" "1.104" "1.140" "1.312" "0.785" "95.5" "102.1" "121.7" "104.9" "99.1" "119.4" "105.5" "108.9" "125.4" "75.0" "" "" "" "" "" "" "" "" "" "" "86.2" "78.7" "94.1" "70.6" "82.7" "101.9" "89.5" "78.8" "84.6" "75.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985839782283071822" "False" "High" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "0.000" "False" "12.851" "4" "2" "3" "2" "480" "54.4" "6.61" "9.61" "2" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "MHC class II antigen presentation; Neutrophil degranulation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "Ciliary landscape" "6" "0" "1.059" "0.984" "0.954" "0.959" "1.164" "0.930" "1.000" "1.174" "0.844" "191.8" "203.1" "188.7" "183.0" "183.9" "223.2" "178.3" "191.8" "225.1" "161.9" "" "" "" "" "" "" "" "" "" "" "173.1" "156.7" "146.0" "123.2" "153.4" "190.5" "151.2" "138.8" "151.8" "161.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1882334441137329574" "False" "High" "IsMasterProtein" "Q9BUJ2" "Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2" "0.000" "False" "12.848" "5" "5" "5" "5" "856" "95.7" "6.92" "13.90" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf02037, Pf13671" "11100" "ENSG00000105323" "HNRNPUL1" "B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75" "" "" "0" "0" "1.140" "1.613" "1.217" "1.197" "1.709" "1.096" "1.063" "1.762" "4.088" "146.7" "167.2" "236.5" "178.5" "175.6" "250.6" "160.7" "155.9" "258.5" "599.6" "" "" "" "" "" "" "" "" "" "" "132.4" "129.0" "183.0" "120.2" "146.5" "213.9" "136.3" "112.8" "174.3" "599.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749791296604860145" "False" "High" "IsMasterProtein" "Q9BTE6" "Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1 PE=1 SV=2" "0.000" "False" "12.839" "9" "3" "4" "3" "412" "45.5" "6.42" "9.99" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07973" "100885850; 80755" "ENSG00000108825; ENSG00000266967" "AARSD1" "B4DI73; hsa:100885850; hsa:80755; Q9BTE6" "" "" "0" "0" "0.903" "0.732" "1.036" "1.024" "0.718" "0.879" "0.916" "0.715" "2.108" "99.3" "89.7" "72.7" "102.9" "101.7" "71.3" "87.3" "90.9" "71.0" "209.3" "" "" "" "" "" "" "" "" "" "" "89.6" "69.2" "56.2" "69.3" "84.8" "60.9" "74.1" "65.8" "47.9" "209.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8237731062455566207" "False" "High" "IsMasterProtein" "P40763" "Signal transducer and activator of transcription 3 OS=Homo sapiens OX=9606 GN=STAT3 PE=1 SV=2" "0.000" "False" "12.836" "5" "4" "5" "4" "770" "88.0" "6.30" "15.72" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6774" "ENSG00000168610" "STAT3" "A8K7B8; hsa:6774; K7ENL3; O14916; P40763; Q9BW54" "Signaling by SCF-KIT; Interleukin-4 and Interleukin-13 signaling; Transcriptional regulation of granulopoiesis; Senescence-Associated Secretory Phenotype (SASP); PKR-mediated signaling; Signaling by ALK fusions and activated point mutants; Interleukin-7 signaling; Downstream signal transduction; Signaling by ALK; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-10 signaling; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; PTK6 Activates STAT3; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; STAT3 nuclear events downstream of ALK signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-23 signaling; Interleukin-27 signaling; Interleukin-37 signaling; Signalling to STAT3; Nuclear events stimulated by ALK signaling in cancer; MET activates STAT3; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "IL-5 signaling pathway; Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Involution (Stage 4 of 4); Dopaminergic neurogenesis; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Estrogen receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Development of pulmonary dendritic cells and macrophage subsets; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Leptin-insulin signaling overlap; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Clear cell renal cell carcinoma pathways; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Extracellular vesicles in the crosstalk of cardiac cells; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Inflammatory bowel disease signaling; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Notch signaling pathway; Serotonin HTR1 group and FOS pathway" "119" "0" "0.944" "0.808" "1.032" "0.972" "0.816" "0.981" "0.683" "0.781" "5.427" "307.8" "290.7" "248.5" "317.8" "299.0" "251.2" "302.0" "210.1" "240.4" "1670.2" "" "" "" "" "" "" "" "" "" "" "277.8" "224.2" "192.2" "214.0" "249.4" "214.4" "256.2" "152.0" "162.1" "1670.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772258242304102193" "False" "High" "IsMasterProtein" "Q9BQE5" "Apolipoprotein L2 OS=Homo sapiens OX=9606 GN=APOL2 PE=1 SV=2" "0.000" "False" "12.818" "9" "3" "3" "3" "337" "37.1" "6.74" "10.69" "3" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf05461" "23780" "ENSG00000128335" "APOL2" "B0QYK7; hsa:23780; O95915; Q59GW9; Q5TH96; Q969T6; Q9BQE5; Q9BT28; Q9UGT1; Q9UH10" "" "" "0" "0" "1.130" "1.039" "1.120" "1.169" "0.988" "1.151" "1.140" "1.024" "1.255" "225.5" "254.8" "234.3" "252.5" "263.6" "222.8" "259.5" "257.1" "231.0" "283.0" "" "" "" "" "" "" "" "" "" "" "203.5" "196.5" "181.2" "170.0" "219.9" "190.1" "220.1" "186.0" "155.8" "283.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4939449039103849626" "False" "High" "IsMasterProtein" "Q96G74" "OTU domain-containing protein 5 OS=Homo sapiens OX=9606 GN=OTUD5 PE=1 SV=1" "0.000" "False" "12.788" "3" "1" "1" "1" "571" "60.6" "6.54" "5.21" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf02338" "55593" "ENSG00000068308; ENSG00000292211" "OTUD5" "B4DGG7; G5E9D7; hsa:55593; Q4KMN9; Q8N6T5; Q96G74; Q9H650; Q9H9U0; Q9NT65" "Ovarian tumor domain proteases; Negative regulators of DDX58/IFIH1 signaling" "Gastric cancer network 2; Novel intracellular components of RIG-I-like receptor pathway" "4" "0" "0.952" "0.886" "1.089" "1.218" "0.812" "1.092" "1.059" "0.787" "1.105" "92.4" "88.0" "81.9" "100.7" "112.6" "75.0" "100.9" "97.9" "72.8" "102.2" "" "" "" "" "" "" "" "" "" "" "83.5" "67.9" "63.4" "67.8" "93.9" "64.1" "85.6" "70.9" "49.1" "102.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348020526010624498" "False" "High" "IsMasterProtein" "Q13469" "Nuclear factor of activated T-cells, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=NFATC2 PE=1 SV=2" "0.000" "False" "12.782" "5" "4" "4" "4" "925" "100.1" "7.28" "11.36" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4773" "ENSG00000101096" "NFATC2" "B5B2N8; B5B2N9; B5B2P0; B5B2P2; B5B2P3; hsa:4773; Q13468; Q13469; Q5TFW7; Q5TFW8; Q9NPX6; Q9NQH3; Q9UJR2" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)" "Heart development; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Hematopoietic stem cell differentiation; Vitamin D receptor pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; CAMKK2 pathway; 16p11.2 distal deletion syndrome; Calcium mediated T-cell apoptosis involved in inclusion body myositis; T-cell receptor signaling pathway" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4849374493010714997" "False" "High" "IsMasterProtein" "Q92673" "Sortilin-related receptor OS=Homo sapiens OX=9606 GN=SORL1 PE=1 SV=2" "0.000" "False" "12.776" "2" "3" "3" "3" "2214" "248.3" "5.55" "9.85" "3" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00041, Pf00057, Pf00058, Pf15901, Pf15902" "6653" "ENSG00000137642" "SORL1" "B2RNX7; hsa:6653; Q92673; Q92856" "Amyloid fiber formation" "" "1" "0" "1.050" "0.867" "1.261" "1.254" "1.097" "1.052" "0.973" "1.090" "1.121" "119.7" "125.6" "103.7" "150.8" "150.1" "131.2" "125.9" "116.4" "130.4" "134.1" "" "" "" "" "" "" "" "" "" "" "108.0" "96.9" "80.2" "101.6" "125.2" "112.0" "106.8" "84.2" "88.0" "134.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2149131157478544716" "False" "High" "IsMasterProtein" "Q6P587" "Oxaloacetate tautomerase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=3" "0.000" "False" "12.774" "14" "3" "5" "3" "221" "24.5" "7.39" "15.62" "3" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.075" "1.238" "1.131" "1.041" "1.141" "1.171" "1.205" "1.186" "0.729" "373.7" "401.7" "462.6" "422.6" "388.8" "426.5" "437.6" "450.4" "443.1" "272.3" "" "" "" "" "" "" "" "" "" "" "337.3" "309.8" "357.8" "284.5" "324.3" "364.0" "371.2" "325.9" "298.9" "272.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2868911152044451366" "False" "High" "IsMasterProtein" "Q99570" "Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3" "0.000" "False" "12.767" "3" "3" "3" "3" "1358" "153.0" "7.17" "9.72" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00400" "30849" "ENSG00000196455" "PIK3R4" "hsa:30849; Q2TBF4; Q99570" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "25" "0" "0.991" "1.018" "1.028" "0.917" "0.970" "1.070" "1.076" "0.895" "1.248" "126.6" "125.5" "129.0" "130.1" "116.2" "122.8" "135.5" "136.3" "113.4" "158.1" "" "" "" "" "" "" "" "" "" "" "114.3" "96.8" "99.7" "87.6" "96.9" "104.8" "114.9" "98.6" "76.5" "158.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1655251497259487415" "False" "High" "IsMasterProtein" "Q9BV38" "WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2" "0.000" "False" "12.761" "6" "3" "3" "3" "432" "47.4" "6.70" "10.90" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf14077" "57418" "ENSG00000065268" "WDR18" "hsa:57418; O60390; Q9BV38; Q9BWR2" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.098" "0.932" "1.073" "1.055" "0.878" "1.037" "1.059" "0.857" "0.923" "197.9" "217.3" "184.5" "212.3" "208.7" "173.7" "205.1" "209.5" "169.6" "182.7" "" "" "" "" "" "" "" "" "" "" "178.6" "167.6" "142.7" "143.0" "174.1" "148.3" "174.0" "151.6" "114.4" "182.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766769550040713609" "False" "High" "IsMasterProtein" "Q9UHI6" "Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2" "0.000" "False" "12.721" "4" "3" "4" "3" "824" "92.2" "6.95" "12.89" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11218" "ENSG00000064703" "DDX20" "B4DWV7; hsa:11218; Q96F72; Q9NVM3; Q9UF59; Q9UHI6; Q9UIY0; Q9Y659" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "mRNA processing; Male infertility" "4" "0" "0.918" "0.903" "1.138" "1.132" "0.846" "0.977" "0.667" "0.913" "5.362" "106.8" "98.0" "96.4" "121.5" "121.0" "90.3" "104.3" "71.3" "97.6" "572.8" "" "" "" "" "" "" "" "" "" "" "96.4" "75.6" "74.6" "81.8" "100.9" "77.1" "88.5" "51.6" "65.8" "572.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094708502747754814" "False" "High" "IsMasterProtein" "P61313" "Large ribosomal subunit protein eL15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "0.000" "False" "12.719" "18" "5" "7" "5" "204" "24.1" "11.62" "21.86" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.970" "1.092" "0.993" "1.082" "0.995" "1.122" "1.021" "1.111" "0.429" "454.3" "440.6" "496.2" "451.3" "491.6" "452.0" "509.8" "464.0" "504.9" "195.1" "" "" "" "" "" "" "" "" "" "" "410.1" "339.9" "383.8" "303.9" "410.1" "385.8" "432.4" "335.8" "340.6" "195.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1302469806401564563" "False" "High" "IsMasterProtein" "P49748" "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1" "0.000" "False" "12.715" "8" "5" "6" "5" "655" "70.3" "8.75" "14.58" "5" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "37" "ENSG00000072778" "ACADVL" "B4DEB6; F5H2A9; hsa:37; O76056; P49748; Q8WUL0" "XBP1(S) activates chaperone genes; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation" "4" "0" "1.105" "1.104" "1.100" "1.101" "0.975" "0.974" "1.125" "1.003" "0.766" "87.6" "96.8" "96.8" "96.4" "96.5" "85.4" "85.3" "98.5" "87.8" "67.1" "" "" "" "" "" "" "" "" "" "" "79.1" "74.6" "74.8" "64.9" "80.5" "72.9" "72.4" "71.3" "59.2" "67.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8080322362920288108" "False" "High" "IsMasterProtein" "Q7Z7F0" "KH homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KHDC4 PE=1 SV=1" "0.000" "False" "12.713" "5" "3" "3" "3" "614" "64.8" "8.73" "9.00" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "" "22889" "ENSG00000132680" "KHDC4" "hsa:22889; O94981; Q7L7Q2; Q7Z7E9; Q7Z7F0; Q8TBQ0" "" "" "0" "0" "0.892" "0.913" "0.900" "0.949" "0.883" "0.967" "0.959" "0.944" "1.373" "178.4" "159.1" "163.0" "160.6" "169.3" "157.5" "172.6" "171.2" "168.4" "245.0" "" "" "" "" "" "" "" "" "" "" "161.1" "122.7" "126.0" "108.1" "141.3" "134.4" "146.4" "123.9" "113.6" "245.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8029509769443933574" "False" "High" "IsMasterProtein" "Q7Z7A3" "Cytoplasmic tRNA 2-thiolation protein 1 OS=Homo sapiens OX=9606 GN=CTU1 PE=1 SV=1" "0.000" "False" "12.713" "11" "3" "4" "3" "348" "36.4" "9.20" "13.02" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01171, Pf16503" "90353" "ENSG00000142544" "CTU1" "A8K558; hsa:90353; Q7Z7A3; Q96GZ7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.990" "0.987" "1.032" "1.077" "0.938" "1.020" "0.923" "1.016" "1.073" "130.5" "129.2" "128.7" "134.6" "140.4" "122.3" "133.1" "120.4" "132.6" "140.0" "" "" "" "" "" "" "" "" "" "" "117.8" "99.6" "99.6" "90.6" "117.2" "104.4" "112.9" "87.1" "89.4" "140.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845152794455651809" "False" "High" "IsMasterProtein" "O75179" "Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3" "0.000" "False" "12.707" "2" "5" "6" "2" "2603" "274.1" "6.52" "16.60" "5" "stress response;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00013, Pf12796, Pf13637" "26057" "ENSG00000132466" "ANKRD17" "E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917272071926626278" "False" "High" "IsMasterProtein" "Q99797" "Mitochondrial intermediate peptidase OS=Homo sapiens OX=9606 GN=MIPEP PE=1 SV=2" "0.000" "False" "12.671" "4" "3" "3" "3" "713" "80.6" "7.05" "10.10" "3" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01432" "4285" "ENSG00000027001" "MIPEP" "hsa:4285; Q5JV15; Q5T9Q9; Q96G65; Q99797" "" "13q12.12 copy number variation" "1" "0" "1.040" "1.005" "1.111" "1.040" "0.891" "1.056" "0.936" "0.986" "1.179" "288.6" "300.3" "290.0" "320.6" "300.1" "257.2" "304.7" "270.2" "284.5" "340.4" "" "" "" "" "" "" "" "" "" "" "260.5" "231.6" "224.3" "215.9" "250.3" "219.6" "258.5" "195.5" "191.9" "340.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-765021547925747573" "False" "High" "IsMasterProtein" "P49366" "Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1" "0.000" "False" "12.652" "8" "2" "2" "2" "369" "40.9" "5.36" "8.33" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01916" "1725" "ENSG00000095059" "DHPS" "A8K688; hsa:1725; M0R1I5; P49366; Q13184; Q13276; Q9UDG0" "Hypusine synthesis from eIF5A-lysine" "" "1" "0" "1.087" "0.892" "1.034" "1.031" "1.082" "0.948" "0.863" "0.992" "0.714" "59.8" "65.0" "53.3" "61.8" "61.6" "64.7" "56.7" "51.6" "59.3" "42.7" "" "" "" "" "" "" "" "" "" "" "54.0" "50.1" "41.2" "41.6" "51.4" "55.2" "48.1" "37.3" "40.0" "42.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321429417116917544" "False" "High" "IsMasterProtein" "P07339" "Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1" "0.000" "False" "12.623" "11" "4" "4" "4" "412" "44.5" "6.54" "12.82" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026, Pf07966" "1509" "ENSG00000117984" "CTSD" "hsa:1509; P07339; Q6IB57" "MHC class II antigen presentation; Neutrophil degranulation; Collagen degradation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins" "Prolactin signaling pathway; 8p23.1 copy number variation syndrome" "8" "0" "1.049" "1.060" "0.963" "1.069" "0.969" "1.015" "1.013" "0.946" "1.081" "227.4" "238.6" "241.0" "218.9" "243.1" "220.4" "230.8" "230.3" "215.2" "245.7" "" "" "" "" "" "" "" "" "" "" "205.3" "184.1" "186.4" "147.4" "202.7" "188.1" "195.8" "166.6" "145.2" "245.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047850882453787868" "False" "High" "IsMasterProtein" "Q96S19" "Methyltransferase-like 26 OS=Homo sapiens OX=9606 GN=METTL26 PE=1 SV=2" "0.000" "False" "12.618" "12" "2" "5" "2" "204" "22.6" "7.83" "14.09" "2" "" "" "other molecular function" "Pf06080" "84326" "ENSG00000130731" "METTL26" "A8MTR1; A8MWJ8; A8MZA1; B4DG95; B4DIJ3; D6REA6; F6TF62; F6VM53; hsa:84326; Q96IW1; Q96MD6; Q96S19" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6260636582982827540" "False" "High" "IsMasterProtein" "Q6YHU6" "tRNA (32-2'-O)-methyltransferase regulator THADA OS=Homo sapiens OX=9606 GN=THADA PE=1 SV=1" "0.000" "False" "12.589" "2" "4" "5" "4" "1953" "219.5" "6.06" "12.46" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity" "Pf10350" "63892" "ENSG00000115970" "THADA" "A8K1V8; B7WNS6; hsa:63892; Q3KR04; Q53RC6; Q53TB2; Q6YHU2; Q6YHU6; Q6ZU38; Q8IY32; Q8TAU8; Q96I88; Q9BZF7; Q9C096; Q9H6U0; Q9H6W7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.952" "0.729" "0.786" "0.867" "0.723" "0.811" "0.842" "0.704" "1.163" "167.4" "159.3" "122.0" "131.6" "145.2" "121.1" "135.8" "140.9" "117.9" "194.7" "" "" "" "" "" "" "" "" "" "" "151.1" "122.9" "94.4" "88.6" "121.1" "103.3" "115.2" "102.0" "79.5" "194.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3185905528720532686" "False" "High" "IsMasterProtein" "P01903" "HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2" "0.000" "False" "12.575" "16" "3" "3" "3" "254" "28.6" "5.00" "8.69" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00993, Pf07654" "3122" "ENSG00000204287; ENSG00000206308; ENSG00000226260; ENSG00000227993; ENSG00000228987; ENSG00000230726; ENSG00000234794; ENSG00000277263" "HLA-DRA" "A2BET4; hsa:3122; P01903; Q30160; Q6IAZ1; Q861I2; Q9TP70" "Downstream TCR signaling; MHC class II antigen presentation; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "Allograft rejection; PI3K/AKT/mTOR - vitamin D3 signaling; Ebola virus infection in host; Male infertility; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; 11p11.2 copy number variation syndrome" "16" "0" "1.122" "1.312" "0.592" "0.625" "1.144" "0.742" "1.103" "0.735" "0.850" "76.8" "86.2" "100.8" "45.5" "48.0" "87.9" "57.0" "84.7" "56.5" "65.3" "" "" "" "" "" "" "" "" "" "" "69.3" "66.5" "77.9" "30.6" "40.0" "75.0" "48.4" "61.3" "38.1" "65.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548984541792378367" "False" "High" "IsMasterProtein" "Q9Y5Y2" "Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1" "0.000" "False" "12.571" "15" "4" "6" "4" "271" "28.8" "5.83" "15.92" "4" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "10101" "ENSG00000095906" "NUBP2" "D3DU80; hsa:10101; Q9NWB2; Q9Y5Y2" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis" "2" "0" "1.062" "0.695" "0.983" "0.973" "0.731" "0.955" "0.984" "0.762" "0.842" "123.5" "131.2" "85.8" "121.5" "120.2" "90.3" "118.0" "121.5" "94.1" "104.0" "" "" "" "" "" "" "" "" "" "" "111.5" "101.2" "66.4" "81.8" "100.3" "77.1" "100.1" "87.9" "63.5" "104.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1710957495581241362" "False" "High" "IsMasterProtein" "Q15276" "Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2" "0.000" "False" "12.555" "5" "5" "5" "5" "862" "99.2" "5.01" "11.28" "5" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03528, Pf09311" "9135" "ENSG00000029725" "RABEP1" "B2RAG7; hsa:9135; O95369; Q15276; Q8IVX3" "TBC/RABGAPs" "GDNF signaling" "2" "0" "1.093" "1.004" "1.117" "0.964" "1.006" "1.086" "1.073" "1.114" "1.262" "274.7" "300.1" "275.9" "306.8" "264.8" "276.2" "298.3" "294.7" "306.1" "346.7" "" "" "" "" "" "" "" "" "" "" "247.9" "231.5" "213.4" "206.6" "220.9" "235.8" "253.0" "213.3" "206.4" "346.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5130532040742567239" "False" "High" "IsMasterProtein" "Q9HCN8" "Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2" "0.000" "False" "12.554" "14" "2" "2" "2" "221" "23.6" "7.03" "9.88" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02815" "23753" "ENSG00000128228" "SDF2L1" "A2RUD3; hsa:23753; Q9BRI5; Q9HCN8" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.043" "1.080" "2.095" "1.115" "1.117" "1.326" "1.092" "1.583" "1.165" "66.1" "68.9" "71.3" "138.4" "73.7" "73.8" "87.6" "72.2" "104.6" "77.0" "" "" "" "" "" "" "" "" "" "" "59.7" "53.2" "55.2" "93.2" "61.5" "63.0" "74.3" "52.2" "70.6" "77.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8773052781393690194" "False" "High" "IsMasterProtein" "Q9Y6X4" "Soluble lamin-associated protein of 75 kDa OS=Homo sapiens OX=9606 GN=FAM169A PE=1 SV=2" "0.000" "False" "12.542" "7" "3" "4" "3" "670" "74.9" "4.60" "10.11" "3" "" "other membranes;nucleus" "" "" "26049" "ENSG00000198780" "FAM169A" "A8K1T9; hsa:26049; Q6MZT0; Q9H989; Q9Y6X4" "RHOF GTPase cycle" "" "1" "0" "1.020" "0.796" "1.056" "1.038" "0.878" "0.973" "0.913" "0.904" "0.825" "270.4" "275.7" "215.1" "285.6" "280.6" "237.5" "263.2" "246.9" "244.5" "223.0" "" "" "" "" "" "" "" "" "" "" "244.1" "212.7" "166.4" "192.3" "234.1" "202.7" "223.2" "178.7" "164.9" "223.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3977231737757699064" "False" "High" "IsMasterProtein" "Q6JBY9" "CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1" "0.000" "False" "12.541" "6" "2" "2" "2" "416" "44.5" "5.40" "6.77" "2" "stress response;transport;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05177, Pf15255" "92241" "ENSG00000198771" "RCSD1" "B1AK48; hsa:92241; Q4G0E7; Q6IN93; Q6JBY9; Q8IZM2; Q96DX0; Q9NST4" "" "" "0" "0" "1.204" "1.131" "1.336" "1.058" "1.219" "1.070" "1.147" "1.163" "0.531" "57.7" "69.4" "65.2" "77.1" "61.0" "70.3" "61.7" "66.2" "67.1" "30.6" "" "" "" "" "" "" "" "" "" "" "52.1" "53.6" "50.5" "51.9" "50.9" "60.0" "52.3" "47.9" "45.2" "30.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6052535811300559173" "False" "High" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "0.000" "False" "12.529" "5" "4" "4" "4" "804" "91.8" "7.42" "10.98" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.896" "0.735" "0.902" "0.885" "0.702" "0.748" "0.743" "0.711" "1.941" "286.9" "257.1" "211.0" "258.8" "253.9" "201.3" "214.5" "213.0" "203.9" "556.7" "" "" "" "" "" "" "" "" "" "" "258.9" "198.3" "163.2" "174.3" "211.8" "171.8" "182.0" "154.1" "137.5" "556.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194587147899025830" "False" "High" "IsMasterProtein" "P30613" "Pyruvate kinase PKLR OS=Homo sapiens OX=9606 GN=PKLR PE=1 SV=2" "0.000" "False" "12.523" "3" "2" "19" "1" "574" "61.8" "7.74" "54.57" "2" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00224, Pf02887" "5313" "ENSG00000143627; ENSG00000262785" "PKLR" "hsa:5313; O75758; P11973; P30613" "" "Clear cell renal cell carcinoma pathways; Nonalcoholic fatty liver disease; 7q11.23 copy number variation syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "5" "0" "1.026" "1.124" "1.315" "1.075" "0.974" "0.966" "1.099" "1.487" "0.822" "28.5" "29.3" "32.1" "37.5" "30.7" "27.8" "27.6" "31.4" "42.4" "23.5" "" "" "" "" "" "" "" "" "" "" "25.8" "22.6" "24.8" "25.3" "25.6" "23.7" "23.4" "22.7" "28.6" "23.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586542513876721198" "False" "High" "IsMasterProtein" "O43502" "DNA repair protein RAD51 homolog 3 OS=Homo sapiens OX=9606 GN=RAD51C PE=1 SV=1" "0.000" "False" "12.523" "6" "2" "2" "2" "376" "42.2" "6.74" "8.24" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5889" "ENSG00000108384" "RAD51C" "hsa:5889; O43502; O43503; Q3B783" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination" "DNA repair pathways, full network" "12" "0" "1.064" "0.930" "1.241" "1.245" "0.892" "1.161" "1.077" "0.911" "1.046" "93.2" "99.2" "86.7" "115.7" "116.0" "83.2" "108.2" "100.4" "84.9" "97.5" "" "" "" "" "" "" "" "" "" "" "84.2" "76.5" "67.0" "77.9" "96.8" "71.0" "91.8" "72.7" "57.3" "97.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910081975799465505" "False" "High" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "0.000" "False" "12.512" "5" "5" "5" "5" "1029" "118.2" "8.47" "12.24" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "mRNA Splicing - Major Pathway" "" "1" "0" "1.009" "1.563" "1.052" "1.109" "1.851" "1.023" "0.867" "1.554" "2.074" "102.8" "103.7" "160.7" "108.2" "114.0" "190.2" "105.1" "89.1" "159.8" "213.2" "" "" "" "" "" "" "" "" "" "" "92.8" "80.0" "124.3" "72.8" "95.1" "162.4" "89.2" "64.5" "107.8" "213.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3077097618423052072" "False" "High" "IsMasterProtein" "Q15032" "R3H domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HDM1 PE=1 SV=3" "0.000" "False" "12.508" "2" "2" "2" "2" "1099" "120.6" "8.75" "7.39" "2" "" "" "" "Pf01424, Pf12752" "23518" "ENSG00000048991" "R3HDM1" "A8K1V0; B3KXQ9; E9PBB4; E9PG42; G5E9G8; hsa:23518; Q15032; Q8IW32" "" "" "0" "0" "1.066" "0.877" "1.111" "1.003" "0.920" "0.988" "1.095" "1.020" "1.230" "140.6" "149.9" "123.2" "156.2" "141.0" "129.3" "139.0" "153.9" "143.4" "172.9" "" "" "" "" "" "" "" "" "" "" "126.9" "115.6" "95.3" "105.2" "117.6" "110.4" "117.9" "111.4" "96.7" "172.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128551820349889228" "False" "High" "IsMasterProtein" "P51531" "Probable global transcription activator SNF2L2 OS=Homo sapiens OX=9606 GN=SMARCA2 PE=1 SV=2" "0.000" "False" "12.499" "2" "4" "4" "1" "1590" "181.2" "7.20" "13.95" "4" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6595" "ENSG00000080503" "SMARCA2" "B1ALG3; B1ALG4; D3DRH4; D3DRH5; hsa:6595; P51531" "RMTs methylate histone arginines; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "Retinoblastoma gene in cancer; Pathways affected in adenoid cystic carcinoma; VEGFA-VEGFR2 signaling; Rett syndrome; Thermogenesis; Kleefstra syndrome" "8" "3" "0.960" "1.030" "1.274" "0.973" "1.033" "0.958" "0.543" "1.251" "9.425" "203.5" "195.3" "209.6" "259.3" "197.9" "210.2" "194.9" "110.6" "254.5" "1917.7" "" "" "" "" "" "" "" "" "" "" "183.7" "150.6" "162.1" "174.6" "165.1" "179.4" "165.3" "80.0" "171.7" "1917.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6527665309278316816" "False" "High" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "0.000" "False" "12.497" "21" "4" "8" "4" "178" "20.5" "8.59" "18.54" "4" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "1.074" "0.881" "1.589" "1.120" "1.058" "0.955" "0.816" "1.202" "0.608" "273.0" "293.1" "240.5" "433.8" "305.8" "288.7" "260.7" "222.7" "328.0" "165.9" "" "" "" "" "" "" "" "" "" "" "246.4" "226.1" "186.0" "292.1" "255.1" "246.4" "221.1" "161.1" "221.2" "165.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246838135834817893" "False" "High" "IsMasterProtein" "O75362" "Zinc finger protein 217 OS=Homo sapiens OX=9606 GN=ZNF217 PE=1 SV=1" "0.000" "False" "12.474" "3" "3" "4" "3" "1048" "115.2" "8.48" "8.78" "3" "other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7764" "ENSG00000171940" "ZNF217" "E1P5Y6; hsa:7764; O75362; Q14DB8" "Estrogen-dependent gene expression" "" "1" "0" "0.911" "0.983" "1.147" "0.865" "0.871" "1.030" "0.957" "0.996" "0.932" "53.0" "48.2" "52.1" "60.8" "45.8" "46.1" "54.6" "50.7" "52.7" "49.4" "" "" "" "" "" "" "" "" "" "" "47.8" "37.2" "40.3" "40.9" "38.2" "39.4" "46.3" "36.7" "35.6" "49.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8377264718886898276" "False" "High" "IsMasterProtein" "Q9Y2K7" "Lysine-specific demethylase 2A OS=Homo sapiens OX=9606 GN=KDM2A PE=1 SV=3" "0.000" "False" "12.469" "2" "2" "2" "2" "1162" "132.7" "7.58" "6.90" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00646, Pf02008, Pf16866, Pf17811" "22992" "ENSG00000173120" "KDM2A" "D4QA03; E9PIL6; hsa:22992; I3VM55; Q49A21; Q4G0M3; Q69YY8; Q9BVH5; Q9H7H5; Q9UK66; Q9Y2K7" "HDMs demethylate histones" "" "1" "0" "1.127" "1.049" "1.024" "0.960" "0.879" "1.046" "1.326" "1.324" "2.384" "42.3" "47.7" "44.4" "43.4" "40.6" "37.2" "44.3" "56.1" "56.1" "100.9" "" "" "" "" "" "" "" "" "" "" "38.2" "36.8" "34.4" "29.2" "33.9" "31.8" "37.6" "40.6" "37.8" "100.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945611468628581935" "False" "High" "IsMasterProtein" "Q96I25" "Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1" "0.000" "False" "12.468" "8" "3" "3" "3" "401" "44.9" "5.97" "9.67" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf01585" "84991" "ENSG00000134453" "RBM17" "hsa:84991; Q96GY6; Q96I25" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.062" "1.716" "1.273" "1.078" "1.533" "1.175" "1.015" "1.514" "1.501" "112.2" "119.2" "192.6" "142.9" "120.9" "172.1" "131.8" "113.9" "169.9" "168.5" "" "" "" "" "" "" "" "" "" "" "101.3" "91.9" "149.0" "96.2" "100.9" "146.9" "111.8" "82.4" "114.6" "168.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040602984972190355" "False" "High" "IsMasterProtein" "Q9Y259" "Choline/ethanolamine kinase OS=Homo sapiens OX=9606 GN=CHKB PE=1 SV=3" "0.000" "False" "12.450" "5" "3" "3" "3" "395" "45.2" "5.49" "10.49" "3" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1120" "ENSG00000100288" "CHKB" "A0PJM6; hsa:1120; Q13388; Q9Y259" "Synthesis of PC; Synthesis of PE" "Fatty acid beta-oxidation; Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "7" "0" "1.103" "0.984" "1.122" "1.102" "0.961" "1.151" "1.158" "1.052" "0.785" "191.8" "211.4" "188.7" "215.1" "211.4" "184.3" "220.7" "222.1" "201.7" "150.6" "" "" "" "" "" "" "" "" "" "" "173.1" "163.1" "146.0" "144.9" "176.3" "157.3" "187.2" "160.7" "136.1" "150.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080832168399393297" "False" "High" "IsMasterProtein" "Q9Y6D6" "Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2" "0.000" "False" "12.447" "2" "5" "6" "3" "1849" "208.6" "5.85" "15.98" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10565" "ENSG00000066777" "ARFGEF1" "hsa:10565; Q9NV46; Q9UFV2; Q9UNL0; Q9Y6D6" "" "" "0" "0" "0.941" "0.965" "0.980" "1.107" "1.065" "1.021" "1.071" "1.053" "1.496" "201.1" "189.3" "194.1" "197.1" "222.5" "214.1" "205.2" "215.4" "211.8" "300.8" "" "" "" "" "" "" "" "" "" "" "181.5" "146.0" "150.2" "132.7" "185.6" "182.8" "174.1" "155.9" "142.9" "300.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604147819280005923" "False" "High" "IsMasterProtein" "P50613" "Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1" "0.000" "False" "12.440" "7" "2" "3" "2" "346" "39.0" "8.47" "9.86" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1022" "ENSG00000134058; ENSG00000277273" "CDK7" "hsa:1022; P50613; Q9BS60; Q9UE19" "RNA polymerase II transcribes snRNA genes; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Cardiac hypertrophic response; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "43" "0" "1.355" "0.953" "1.082" "1.185" "1.048" "1.182" "1.184" "1.243" "1.147" "70.9" "96.1" "67.6" "76.7" "84.1" "74.3" "83.9" "84.0" "88.2" "81.4" "" "" "" "" "" "" "" "" "" "" "64.0" "74.1" "52.3" "51.7" "70.1" "63.4" "71.1" "60.8" "59.5" "81.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5244686502761723114" "False" "High" "IsMasterProtein" "P22090" "Small ribosomal subunit protein eS4, Y isoform 1 OS=Homo sapiens OX=9606 GN=RPS4Y1 PE=1 SV=2" "0.000" "False" "12.439" "10" "3" "6" "1" "263" "29.4" "10.24" "17.36" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6192" "ENSG00000129824" "RPS4Y1" "A8K9V4; hsa:6192; P22090" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1948602544583202968" "False" "High" "IsMasterProtein" "Q13042" "Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2" "0.000" "False" "12.436" "5" "3" "3" "3" "620" "71.6" "5.85" "10.33" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf12895, Pf13424" "8881" "ENSG00000130177" "CDC16" "A2A365; hsa:8881; Q13042; Q5T8C8; Q7Z651; Q96AE6; Q9Y564" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "2.413" "1.377" "1.817" "2.243" "1.847" "2.419" "1.750" "2.181" "2.064" "11.2" "27.0" "15.4" "20.3" "25.1" "20.7" "27.1" "19.6" "24.4" "23.1" "" "" "" "" "" "" "" "" "" "" "10.1" "20.8" "11.9" "13.7" "20.9" "17.6" "22.9" "14.2" "16.5" "23.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2318951358478494228" "False" "High" "IsMasterProtein" "Q8WW01" "tRNA-splicing endonuclease subunit Sen15 OS=Homo sapiens OX=9606 GN=TSEN15 PE=1 SV=1" "0.000" "False" "12.426" "11" "1" "2" "1" "171" "18.6" "4.58" "8.16" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf09631" "116461" "ENSG00000198860" "TSEN15" "B4DKP0; hsa:116461; Q8WW01; Q9BZQ5" "tRNA processing in the nucleus" "" "1" "0" "1.127" "0.906" "0.913" "0.980" "0.914" "0.998" "1.034" "0.954" "0.838" "63.6" "71.7" "57.7" "58.1" "62.3" "58.2" "63.5" "65.8" "60.7" "53.3" "" "" "" "" "" "" "" "" "" "" "57.4" "55.3" "44.6" "39.1" "52.0" "49.7" "53.9" "47.6" "40.9" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7438852567896609676" "False" "High" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "0.000" "False" "12.425" "11" "4" "5" "4" "327" "36.1" "5.73" "15.56" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "DNA Damage Recognition in GG-NER; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "6" "0" "1.064" "1.044" "1.025" "1.010" "1.079" "1.154" "1.078" "1.031" "0.905" "354.4" "377.1" "370.1" "363.2" "357.9" "382.4" "408.9" "382.0" "365.6" "320.9" "" "" "" "" "" "" "" "" "" "" "319.9" "290.8" "286.2" "244.6" "298.5" "326.4" "346.9" "276.4" "246.6" "320.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3208600518816650541" "False" "High" "IsMasterProtein" "Q96IU4" "Putative protein-lysine deacylase ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1" "0.000" "False" "12.383" "11" "2" "5" "2" "210" "22.3" "6.40" "14.10" "2" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12697" "84836" "ENSG00000114779" "ABHD14B" "hsa:84836; Q86VK8; Q8N8W5; Q96IU4" "Cytosolic sulfonation of small molecules" "" "1" "0" "0.992" "1.054" "1.103" "1.103" "1.032" "0.967" "1.023" "1.181" "0.927" "357.3" "354.6" "376.5" "394.1" "394.0" "368.7" "345.4" "365.4" "421.9" "331.1" "" "" "" "" "" "" "" "" "" "" "322.6" "273.5" "291.2" "265.4" "328.7" "314.7" "293.0" "264.4" "284.6" "331.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6332903783671194577" "False" "High" "IsMasterProtein" "P62070" "Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1" "0.000" "False" "12.380" "17" "3" "3" "3" "204" "23.4" "6.01" "8.94" "3" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00071" "22800" "ENSG00000133818" "RRAS2" "B2R9Z3; B7Z5Z2; B7Z6C4; B7Z7H6; hsa:22800; P17082; P62070" "RND1 GTPase cycle" "MAPK signaling pathway; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGFR tyrosine kinase inhibitor resistance; Regulation of actin cytoskeleton" "6" "0" "0.972" "0.838" "1.012" "0.921" "0.844" "0.910" "0.718" "0.621" "0.656" "82.1" "79.8" "68.8" "83.1" "75.7" "69.3" "74.8" "59.0" "51.0" "53.9" "" "" "" "" "" "" "" "" "" "" "74.1" "61.6" "53.2" "56.0" "63.1" "59.2" "63.4" "42.7" "34.4" "53.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635739719901529146" "False" "High" "IsMasterProtein" "Q8TB03" "Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1" "0.000" "False" "12.373" "15" "4" "4" "4" "319" "36.6" "6.30" "12.46" "4" "" "" "" "Pf15112" "159013" "ENSG00000185753" "CXorf38" "B3KW28; D3DWB5; hsa:159013; Q5JPF5; Q8N941; Q8TB03" "" "" "0" "0" "0.934" "0.754" "0.517" "0.835" "0.778" "0.940" "1.050" "0.599" "0.874" "172.5" "161.1" "130.0" "89.3" "144.0" "134.2" "162.2" "181.1" "103.4" "150.7" "" "" "" "" "" "" "" "" "" "" "155.7" "124.2" "100.6" "60.1" "120.1" "114.6" "137.6" "131.1" "69.7" "150.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-221730190353322517" "False" "High" "IsMasterProtein" "Q9UL63" "Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2" "0.000" "False" "12.362" "3" "2" "2" "2" "735" "84.7" "6.34" "8.68" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf06588, Pf13415" "4289" "ENSG00000128585" "MKLN1" "A4D1M8; A6NG43; hsa:4289; Q9NSK4; Q9NUS8; Q9UL63" "" "Ciliary landscape" "1" "0" "0.994" "0.964" "1.178" "1.094" "0.985" "0.959" "1.049" "0.770" "1.231" "51.7" "51.4" "49.8" "60.8" "56.5" "50.9" "49.5" "54.2" "39.8" "63.6" "" "" "" "" "" "" "" "" "" "" "46.6" "39.6" "38.5" "41.0" "47.2" "43.4" "42.0" "39.2" "26.8" "63.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1467078136555344062" "False" "High" "IsMasterProtein" "Q8NHZ8" "Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1" "0.000" "False" "12.345" "24" "2" "4" "2" "85" "9.8" "6.81" "12.13" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10471" "246184" "ENSG00000176386" "CDC26" "hsa:246184; Q8NHZ8" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "" "18" "0" "1.012" "0.999" "1.430" "1.278" "0.944" "1.176" "1.327" "0.866" "1.050" "38.8" "39.3" "38.8" "55.5" "49.6" "36.7" "45.6" "51.5" "33.6" "40.8" "" "" "" "" "" "" "" "" "" "" "35.0" "30.3" "30.0" "37.4" "41.4" "31.3" "38.7" "37.3" "22.7" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5758316461638693187" "False" "High" "IsMasterProtein" "Q05519" "Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1" "0.000" "False" "12.339" "6" "2" "2" "2" "484" "53.5" "10.52" "6.52" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00076" "9295" "ENSG00000116754" "SRSF11" "hsa:9295; Q05519; Q5T758; Q8IWE6" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "5" "0" "0.992" "1.319" "1.136" "1.146" "1.114" "1.494" "0.788" "1.208" "2.029" "28.0" "27.8" "37.0" "31.8" "32.1" "31.2" "41.9" "22.1" "33.8" "56.8" "" "" "" "" "" "" "" "" "" "" "25.3" "21.4" "28.6" "21.4" "26.8" "26.6" "35.5" "16.0" "22.8" "56.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965973480370309944" "False" "High" "IsMasterProtein" "Q53HC9" "EARP and GARP complex-interacting protein 1 OS=Homo sapiens OX=9606 GN=EIPR1 PE=1 SV=2" "0.000" "False" "12.337" "7" "3" "4" "3" "387" "43.6" "5.06" "13.35" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "" "Pf00400" "7260" "ENSG00000032389" "EIPR1" "D6W4Y1; hsa:7260; O43179; Q53HC9; Q53S19; Q53SG2" "" "Ciliary landscape" "1" "0" "0.990" "0.961" "1.058" "0.992" "0.876" "0.994" "1.053" "0.992" "0.954" "293.4" "290.6" "281.9" "310.5" "291.0" "257.1" "291.6" "309.1" "291.2" "279.9" "" "" "" "" "" "" "" "" "" "" "264.8" "224.2" "218.0" "209.1" "242.7" "219.4" "247.3" "223.7" "196.4" "279.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1386453636298102119" "False" "High" "IsMasterProtein" "Q8NDH3" "Probable aminopeptidase NPEPL1 OS=Homo sapiens OX=9606 GN=NPEPL1 PE=1 SV=3" "0.000" "False" "12.335" "4" "2" "2" "2" "523" "55.8" "6.87" "7.46" "2" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf18295" "79716" "ENSG00000215440" "NPEPL1" "A6NGZ0; B4DMW7; B7ZBN0; E9PN47; G5EA34; hsa:79716; Q53G37; Q5W083; Q8NDH3; Q8TF28; Q8WUI2; Q9H1T6; Q9HAI5" "" "" "0" "0" "1.173" "1.032" "1.156" "1.119" "1.141" "1.065" "0.999" "1.138" "0.859" "141.3" "165.7" "145.9" "163.3" "158.1" "161.2" "150.4" "141.1" "160.8" "121.3" "" "" "" "" "" "" "" "" "" "" "127.5" "127.8" "112.8" "110.0" "131.9" "137.6" "127.6" "102.1" "108.5" "121.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772663144839085983" "False" "High" "IsMasterProtein" "O14965" "Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=3" "0.000" "False" "12.329" "8" "3" "4" "3" "403" "45.8" "9.39" "11.39" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6790" "ENSG00000087586" "AURKA" "E1P5F9; hsa:6790; O14965; O60445; O75873; Q9BQD6; Q9UPG5" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA" "Gastric cancer network 1; EGF/EGFR signaling pathway; p53 transcriptional gene network; HDAC6 interactions in the central nervous system" "12" "0" "0.933" "0.729" "0.904" "0.903" "0.747" "1.021" "0.989" "0.885" "1.461" "58.1" "54.2" "42.3" "52.5" "52.4" "43.4" "59.3" "57.5" "51.4" "84.9" "" "" "" "" "" "" "" "" "" "" "52.4" "41.8" "32.7" "35.4" "43.7" "37.0" "50.3" "41.6" "34.7" "84.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8021819990662325449" "False" "High" "IsMasterProtein" "O43760" "Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1" "0.000" "False" "12.327" "13" "3" "5" "3" "224" "24.8" "4.94" "16.13" "3" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01284" "9144" "ENSG00000108639" "SYNGR2" "hsa:9144; O43760; O43762; Q3KQZ2; Q658S7" "" "" "0" "0" "1.102" "0.912" "1.177" "1.138" "0.973" "1.192" "1.112" "0.985" "1.159" "169.1" "186.4" "154.3" "199.0" "192.4" "164.5" "201.5" "188.1" "166.6" "196.1" "" "" "" "" "" "" "" "" "" "" "152.7" "143.8" "119.3" "134.0" "160.5" "140.4" "171.0" "136.1" "112.4" "196.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3564822305630524625" "False" "High" "IsMasterProtein" "Q96M27" "Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1" "0.000" "False" "12.323" "4" "2" "3" "2" "445" "46.7" "5.83" "8.93" "2" "" "ER/Golgi;other cell component" "other molecular function" "Pf01931" "133619" "ENSG00000164244" "PRRC1" "hsa:133619; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3; Q96M27" "" "" "0" "0" "0.986" "1.040" "1.018" "0.984" "1.031" "0.997" "1.094" "1.015" "0.769" "275.7" "271.9" "286.6" "280.7" "271.3" "284.2" "274.8" "301.7" "279.7" "212.0" "" "" "" "" "" "" "" "" "" "" "248.9" "209.7" "221.7" "189.0" "226.3" "242.6" "233.1" "218.3" "188.7" "212.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3244624518097785869" "False" "High" "IsMasterProtein" "Q676U5" "Autophagy-related protein 16-1 OS=Homo sapiens OX=9606 GN=ATG16L1 PE=1 SV=2" "0.000" "False" "12.310" "6" "4" "4" "4" "607" "68.2" "6.64" "11.69" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf08614" "55054" "ENSG00000085978; ENSG00000281089" "ATG16L1" "A3EXK9; A3EXL0; B6ZDH0; hsa:55054; Q676U5; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619" "Macroautophagy" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "8" "0" "1.264" "1.203" "1.163" "1.047" "0.970" "1.170" "1.190" "1.065" "0.727" "73.6" "93.0" "88.5" "85.6" "77.1" "71.4" "86.1" "87.6" "78.4" "53.5" "" "" "" "" "" "" "" "" "" "" "66.4" "71.7" "68.5" "57.6" "64.3" "60.9" "73.0" "63.4" "52.9" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7521593605618506386" "False" "High" "IsMasterProtein" "Q02556" "Interferon regulatory factor 8 OS=Homo sapiens OX=9606 GN=IRF8 PE=1 SV=2" "0.000" "False" "12.299" "12" "5" "5" "5" "426" "48.3" "6.77" "13.93" "5" "other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3394" "ENSG00000140968" "IRF8" "A0AV82; hsa:3394; Q02556" "Interferon gamma signaling; Interferon alpha/beta signaling" "Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Extrafollicular and follicular B cell activation by SARS-CoV-2; 2q37 copy number variation syndrome; Type II interferon signaling" "7" "0" "1.028" "0.992" "1.110" "0.976" "1.263" "1.038" "0.903" "1.225" "3.584" "147.1" "151.1" "145.9" "163.2" "143.6" "185.7" "152.7" "132.9" "180.2" "527.1" "" "" "" "" "" "" "" "" "" "" "132.8" "116.6" "112.8" "109.9" "119.8" "158.5" "129.5" "96.1" "121.6" "527.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7801299591553380074" "False" "High" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "0.000" "False" "12.266" "17" "3" "5" "3" "156" "18.0" "8.21" "13.17" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Processing of Intronless Pre-mRNAs; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing; 3q29 copy number variation syndrome" "29" "0" "0.989" "1.003" "1.063" "1.011" "1.019" "0.907" "0.999" "1.144" "0.925" "144.4" "142.8" "144.9" "153.5" "145.9" "147.1" "130.9" "144.2" "165.2" "133.6" "" "" "" "" "" "" "" "" "" "" "130.3" "110.2" "112.0" "103.4" "121.7" "125.5" "111.0" "104.4" "111.4" "133.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1498458301552967093" "False" "High" "IsMasterProtein" "P13716" "Delta-aminolevulinic acid dehydratase OS=Homo sapiens OX=9606 GN=ALAD PE=1 SV=1" "0.000" "False" "12.265" "13" "3" "3" "3" "330" "36.3" "6.79" "8.46" "3" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00490" "210" "ENSG00000148218" "ALAD" "A8K375; B2R6F2; hsa:210; P13716; Q16870; Q16871; Q9BVQ9" "Neutrophil degranulation; Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "683503187076847751" "False" "High" "IsMasterProtein" "Q96AZ6" "Interferon-stimulated gene 20 kDa protein OS=Homo sapiens OX=9606 GN=ISG20 PE=1 SV=2" "0.000" "False" "12.260" "19" "3" "5" "3" "181" "20.4" "8.92" "13.76" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "3669" "ENSG00000172183" "ISG20" "hsa:3669; O00441; O00586; Q96AZ6" "Interferon alpha/beta signaling" "" "1" "0" "1.138" "1.314" "1.190" "1.235" "1.134" "1.129" "1.066" "1.253" "1.305" "136.9" "155.7" "179.9" "162.9" "169.0" "155.3" "154.6" "146.0" "171.5" "178.7" "" "" "" "" "" "" "" "" "" "" "123.6" "120.1" "139.2" "109.7" "141.0" "132.5" "131.1" "105.6" "115.7" "178.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-989694424414112882" "False" "High" "IsMasterProtein" "Q6P2P2" "Protein arginine N-methyltransferase 9 OS=Homo sapiens OX=9606 GN=PRMT9 PE=1 SV=1" "0.000" "False" "12.253" "6" "4" "4" "4" "845" "94.4" "5.25" "10.49" "4" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf06325" "90826" "ENSG00000164169" "PRMT9" "A8KA39; B3KU92; hsa:90826; Q6P2P2; Q6ZR58; Q8N383; Q9BT55; Q9NT98" "" "" "0" "0" "1.086" "0.921" "1.109" "1.152" "1.072" "1.082" "0.894" "1.084" "1.094" "40.0" "43.5" "36.9" "44.4" "46.1" "42.9" "43.3" "35.8" "43.4" "43.8" "" "" "" "" "" "" "" "" "" "" "36.1" "33.5" "28.5" "29.9" "38.5" "36.6" "36.7" "25.9" "29.3" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026902710649246041" "False" "High" "IsMasterProtein" "P14151" "L-selectin OS=Homo sapiens OX=9606 GN=SELL PE=1 SV=2" "0.000" "False" "12.250" "7" "2" "3" "2" "372" "42.2" "6.60" "9.50" "2" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00008, Pf00059, Pf00084" "6402" "ENSG00000188404" "SELL" "A0A024R8Z0; B2R6Q8; hsa:6402; P14151; P15023; Q9UJ43" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Neutrophil degranulation" "Complement system; Extrafollicular and follicular B cell activation by SARS-CoV-2" "5" "0" "1.264" "0.918" "1.156" "1.073" "0.839" "1.091" "1.089" "0.837" "0.725" "89.4" "113.0" "82.1" "103.4" "95.9" "75.0" "97.6" "97.4" "74.9" "64.8" "" "" "" "" "" "" "" "" "" "" "80.7" "87.2" "63.5" "69.6" "80.0" "64.0" "82.8" "70.5" "50.5" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128972635678329678" "False" "High" "IsMasterProtein" "Q9BUT1" "Dehydrogenase/reductase SDR family member 6 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "0.000" "False" "12.234" "9" "2" "3" "2" "245" "26.7" "7.65" "10.16" "2" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "Synthesis of Ketone Bodies" "" "1" "0" "1.034" "1.073" "1.340" "1.170" "1.153" "1.154" "0.870" "1.120" "0.863" "86.5" "89.4" "92.8" "115.8" "101.2" "99.7" "99.8" "75.2" "96.8" "74.6" "" "" "" "" "" "" "" "" "" "" "78.1" "69.0" "71.8" "78.0" "84.4" "85.1" "84.6" "54.4" "65.3" "74.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8467787264096672406" "False" "High" "IsMasterProtein" "O00506" "Serine/threonine-protein kinase 25 OS=Homo sapiens OX=9606 GN=STK25 PE=1 SV=1" "0.000" "False" "12.228" "9" "3" "3" "1" "426" "48.1" "6.74" "9.25" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "10494" "ENSG00000115694" "STK25" "A8K6Z3; A8K7D2; B7Z9K1; hsa:10494; O00506; Q15522; Q5BJF1" "" "2q37 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5527327330749920032" "False" "High" "IsMasterProtein" "P61019" "Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1" "0.000" "False" "12.228" "18" "4" "4" "4" "212" "23.5" "6.54" "11.60" "4" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "5862" "ENSG00000104388" "RAB2A" "B2R5W8; B4DMQ5; hsa:5862; P08886; P61019" "RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "4" "0" "1.009" "1.213" "1.030" "1.073" "1.337" "1.017" "1.070" "1.231" "0.859" "214.4" "216.3" "260.2" "220.8" "230.0" "286.8" "218.0" "229.5" "264.0" "184.2" "" "" "" "" "" "" "" "" "" "" "193.6" "166.9" "201.2" "148.7" "191.8" "244.8" "184.9" "166.1" "178.0" "184.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2291665734159650582" "False" "High" "IsMasterProtein" "P62310" "U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2" "0.000" "False" "12.227" "12" "1" "5" "1" "102" "11.8" "4.70" "15.45" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27258" "ENSG00000170860" "LSM3" "hsa:27258; P62310; Q6IAH0; Q9Y4Z1" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "1.062" "1.004" "1.137" "0.964" "0.976" "0.943" "0.948" "1.062" "0.673" "204.0" "216.7" "204.8" "232.1" "196.7" "199.2" "192.5" "193.4" "216.7" "137.4" "" "" "" "" "" "" "" "" "" "" "184.2" "167.1" "158.4" "156.3" "164.0" "170.0" "163.3" "139.9" "146.2" "137.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-207036045185728456" "False" "High" "IsMasterProtein" "A0A1B0GTU1" "Zinc finger CCCH domain-containing protein 11B OS=Homo sapiens OX=9606 GN=ZC3H11B PE=1 SV=1" "0.000" "False" "12.217" "4" "2" "2" "2" "805" "88.9" "6.81" "7.50" "2" "other metabolic processes;transport" "" "other molecular function" "Pf15663" "" "ENSG00000215817" "ZC3H11B" "A0A1B0GTU1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181742408378363027" "False" "High" "IsMasterProtein" "P62253" "Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3" "0.000" "False" "12.206" "11" "1" "2" "1" "170" "19.5" "5.30" "6.83" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "7326" "ENSG00000132388" "UBE2G1" "B2R7P2; D3DTK0; hsa:7326; P62253; Q99462" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4995035234308884546" "False" "High" "IsMasterProtein" "Q9Y6B6" "Small COPII coat GTPase SAR1B OS=Homo sapiens OX=9606 GN=SAR1B PE=1 SV=1" "0.000" "False" "12.203" "15" "3" "4" "1" "198" "22.4" "6.11" "12.42" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00025" "51128" "ENSG00000152700" "SAR1B" "D3DQA4; hsa:51128; Q567T4; Q9Y6B6" "MHC class II antigen presentation; COPII-mediated vesicle transport; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Chylomicron assembly" "Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism; Enterocyte cholesterol metabolism" "10" "0" "0.823" "0.865" "1.031" "0.868" "0.772" "0.908" "1.135" "0.802" "0.791" "69.9" "57.5" "60.4" "72.0" "60.6" "53.9" "63.4" "79.3" "56.0" "55.2" "" "" "" "" "" "" "" "" "" "" "63.1" "44.4" "46.7" "48.5" "50.6" "46.0" "53.8" "57.4" "37.8" "55.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037316955710450301" "False" "High" "IsMasterProtein" "P38936" "Cyclin-dependent kinase inhibitor 1 OS=Homo sapiens OX=9606 GN=CDKN1A PE=1 SV=3" "0.000" "False" "12.167" "11" "1" "2" "1" "164" "18.1" "8.37" "5.12" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf02234" "1026" "ENSG00000124762" "CDKN1A" "hsa:1026; P38936; Q14010; Q6FI05; Q9BUT4" "Senescence-Associated Secretory Phenotype (SASP); Signaling by ALK fusions and activated point mutants; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; The role of GTSE1 in G2/M progression after G2 checkpoint; Neddylation; KEAP1-NFE2L2 pathway; Constitutive Signaling by AKT1 E17K in Cancer; SCF(Skp2)-mediated degradation of p27/p21; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); FOXO-mediated transcription of cell cycle genes; AKT phosphorylates targets in the cytosol; Transcriptional regulation by RUNX2; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; p53-Dependent G1 DNA Damage Response; TFAP2 (AP-2) family regulates transcription of cell cycle factors; Signaling by FLT3 fusion proteins; RUNX3 regulates CDKN1A transcription; Transcriptional activation of cell cycle inhibitor p21 ; STAT5 activation downstream of FLT3 ITD mutants" "Androgen receptor signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated cancer pathway; Glioblastoma signaling pathways; Adipogenesis; Retinoblastoma gene in cancer; ATM signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Aryl hydrocarbon receptor pathway; Bladder cancer; Apoptosis-related network due to altered Notch3 in ovarian cancer; Vitamin D receptor pathway; miR-517 relationship with ARCN1 and USP1; Photodynamic therapy-induced AP-1 survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; Physico-chemical features and toxicity-associated pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Type 2 papillary renal cell carcinoma; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; FGF23 signaling in hypophosphatemic rickets and related disorders; Overlap between signal transduction pathways contributing to LMNA laminopathies; p53 transcriptional gene network; Galanin receptor pathway; Pleural mesothelioma; Orexin receptor pathway; Lipid metabolism in senescent cells; Pathophysiological roles of DUX4 in FSHD1; Omega-6-fatty acids in senescence; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent); Androgen receptor signaling pathway" "79" "0" "0.982" "0.938" "1.392" "0.917" "0.956" "0.998" "0.998" "1.282" "0.894" "20.1" "19.7" "18.8" "27.9" "18.4" "19.2" "20.0" "20.0" "25.7" "17.9" "" "" "" "" "" "" "" "" "" "" "18.1" "15.2" "14.6" "18.8" "15.3" "16.4" "17.0" "14.5" "17.3" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2189379826665428433" "False" "High" "IsMasterProtein" "Q9UMY1" "U3 small nucleolar RNA-associated protein NOL7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2" "0.000" "False" "12.151" "11" "3" "3" "3" "257" "29.4" "9.67" "10.11" "3" "other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf08157" "51406" "ENSG00000225921" "NOL7" "hsa:51406; Q5T297; Q9UMY1; Q9Y3U7" "" "" "0" "0" "1.016" "1.175" "0.925" "1.108" "1.279" "0.882" "1.114" "1.216" "0.450" "174.3" "177.1" "204.8" "161.2" "193.1" "223.0" "153.7" "194.1" "211.9" "78.4" "" "" "" "" "" "" "" "" "" "" "157.3" "136.6" "158.4" "108.5" "161.1" "190.3" "130.4" "140.4" "142.9" "78.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4363739394428502664" "False" "High" "IsMasterProtein" "O75330" "Hyaluronan mediated motility receptor OS=Homo sapiens OX=9606 GN=HMMR PE=1 SV=2" "0.000" "False" "12.146" "6" "5" "5" "5" "724" "84.0" "5.83" "9.35" "5" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15905, Pf15908" "3161" "ENSG00000072571" "HMMR" "A8K3G2; B4E114; D3DQK9; D3DQL0; E9PCS0; hsa:3161; O75330; Q32N02; Q92767" "AURKA Activation by TPX2; Hyaluronan uptake and degradation" "" "2" "0" "1.209" "1.167" "1.403" "1.214" "0.808" "1.268" "1.417" "1.312" "3.649" "18.7" "22.6" "21.8" "26.3" "22.7" "15.1" "23.7" "26.5" "24.6" "68.3" "" "" "" "" "" "" "" "" "" "" "16.9" "17.4" "16.9" "17.7" "19.0" "12.9" "20.1" "19.2" "16.6" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5046480723636324863" "False" "High" "IsMasterProtein" "Q9Y314" "Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1" "0.000" "False" "12.114" "8" "2" "2" "2" "301" "33.2" "8.82" "7.26" "2" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15906" "51070" "ENSG00000142546" "NOSIP" "Q96FD2; Q9Y314" "NOSIP mediated eNOS trafficking" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3953931010856732739" "False" "High" "IsMasterProtein" "P16104" "Histone H2AX OS=Homo sapiens OX=9606 GN=H2AX PE=1 SV=2" "0.000" "False" "12.114" "27" "5" "10" "2" "143" "15.1" "10.74" "26.05" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "3014" "ENSG00000188486" "H2AX" "hsa:3014; P16104; Q4ZGJ7; Q6IAS5" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Assembly of the ORC complex at the origin of replication; Amyloid fiber formation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; RMTs methylate histone arginines; Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Proteasome degradation; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DNA repair pathways, full network; 5q35 copy number variation; DNA damage response" "47" "2" "1.005" "1.179" "1.053" "1.037" "1.021" "1.051" "1.010" "1.195" "0.918" "588.4" "591.4" "693.9" "619.4" "610.1" "600.7" "618.4" "594.1" "703.0" "540.3" "" "" "" "" "" "" "" "" "" "" "531.2" "456.2" "536.7" "417.1" "508.9" "512.7" "524.6" "430.0" "474.1" "540.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3092682979585279254" "False" "High" "IsMasterProtein" "Q96BP3" "Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1" "0.000" "False" "12.109" "8" "6" "6" "6" "646" "73.5" "7.15" "18.31" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160, Pf00400" "23398" "ENSG00000113593" "PPWD1" "B4DWR9; hsa:23398; Q15002; Q7KZ89; Q96BP3" "mRNA Splicing - Major Pathway" "" "1" "0" "0.902" "0.914" "0.741" "0.877" "1.129" "0.969" "0.915" "0.994" "1.250" "135.3" "122.1" "123.6" "100.2" "118.7" "152.8" "131.2" "123.8" "134.5" "169.2" "" "" "" "" "" "" "" "" "" "" "122.2" "94.2" "95.6" "67.5" "99.0" "130.4" "111.3" "89.6" "90.7" "169.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7603913648578901731" "False" "High" "IsMasterProtein" "Q5VWZ2" "Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3" "0.000" "False" "12.107" "14" "4" "6" "4" "237" "26.3" "7.84" "19.90" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02230" "127018" "ENSG00000143353" "LYPLAL1" "A8K677; hsa:127018; Q5VWZ2; Q5VWZ3; Q7Z4A3; Q96AV0" "" "" "0" "0" "1.016" "1.124" "1.048" "0.992" "1.030" "1.038" "1.039" "1.096" "0.958" "889.8" "903.9" "1000.0" "932.7" "882.2" "916.5" "923.9" "924.8" "975.3" "852.1" "" "" "" "" "" "" "" "" "" "" "803.2" "697.2" "773.5" "628.1" "735.9" "782.3" "783.7" "669.3" "657.8" "852.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4617078502424805251" "False" "High" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "0.000" "False" "12.097" "4" "2" "4" "2" "520" "60.7" "6.77" "11.32" "2" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "1.058" "1.037" "1.030" "1.044" "0.903" "0.945" "1.035" "0.998" "0.670" "453.2" "479.6" "470.0" "466.7" "472.9" "409.3" "428.2" "468.9" "452.2" "303.4" "" "" "" "" "" "" "" "" "" "" "409.1" "369.9" "363.5" "314.2" "394.5" "349.3" "363.2" "339.4" "305.0" "303.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796563562417500540" "False" "High" "IsMasterProtein" "P51532" "Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2" "0.000" "False" "12.081" "2" "4" "4" "1" "1647" "184.5" "7.88" "13.07" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6597" "ENSG00000127616" "SMARCA4" "B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; hsa:6597; O95052; P51532; Q9HBD3" "Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Interleukin-7 signaling; RMTs methylate histone arginines; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "Androgen receptor network in prostate cancer; Pre-implantation embryo; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Tumor suppressor activity of SMARCB1; Rett syndrome; Thermogenesis; Kleefstra syndrome" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1329067276742603011" "False" "High" "IsMasterProtein" "Q8WYP5" "Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3" "0.000" "False" "12.064" "1" "2" "2" "2" "2266" "252.3" "6.60" "7.28" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf13934, Pf16687" "25909" "ENSG00000153207" "AHCTF1" "A6NGM0; A8MSG9; A8MZ86; hsa:25909; Q7Z4E3; Q8IZA4; Q8WYP5; Q96EH9; Q9Y4Q6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "Gastric cancer network 2" "8" "0" "0.747" "2.407" "0.978" "1.047" "2.143" "1.148" "1.027" "2.271" "1.232" "59.8" "44.6" "143.9" "58.5" "62.6" "128.1" "68.6" "61.4" "135.8" "73.7" "" "" "" "" "" "" "" "" "" "" "54.0" "34.4" "111.3" "39.4" "52.2" "109.3" "58.2" "44.4" "91.6" "73.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2027123753413932420" "False" "High" "IsMasterProtein" "Q8NBN7" "Retinol dehydrogenase 13 OS=Homo sapiens OX=9606 GN=RDH13 PE=1 SV=2" "0.000" "False" "12.062" "9" "3" "3" "3" "331" "35.9" "8.10" "10.12" "3" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00106" "112724" "ENSG00000160439; ENSG00000273944; ENSG00000274418; ENSG00000274504; ENSG00000275474; ENSG00000276341; ENSG00000276684; ENSG00000276826; ENSG00000278149; ENSG00000278284" "RDH13" "Q6UX79; Q8NBN7; Q96G88" "RA biosynthesis pathway" "" "1" "0" "1.022" "0.720" "1.157" "0.868" "0.578" "0.940" "1.106" "0.740" "0.714" "183.8" "187.9" "132.3" "212.7" "159.5" "106.2" "172.8" "203.3" "136.1" "131.2" "" "" "" "" "" "" "" "" "" "" "165.9" "144.9" "102.4" "143.3" "133.0" "90.7" "146.6" "147.2" "91.8" "131.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8016840892543387759" "False" "High" "IsMasterProtein" "Q9P2F8" "Signal-induced proliferation-associated 1-like protein 2 OS=Homo sapiens OX=9606 GN=SIPA1L2 PE=1 SV=2" "0.000" "False" "12.051" "1" "1" "2" "1" "1722" "190.3" "6.77" "9.07" "1" "other biological processes" "other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf11881, Pf21022" "57568" "ENSG00000116991" "SIPA1L2" "hsa:57568; Q2TV88; Q5VXR7; Q5VXR8; Q641Q4; Q8NA38; Q96DZ3; Q9H9F6; Q9P2F8" "" "" "0" "0" "1.402" "1.145" "1.066" "1.050" "1.284" "1.271" "1.167" "1.209" "2.946" "38.1" "53.5" "43.7" "40.6" "40.0" "49.0" "48.5" "44.5" "46.1" "112.4" "" "" "" "" "" "" "" "" "" "" "34.4" "41.2" "33.8" "27.4" "33.4" "41.8" "41.1" "32.2" "31.1" "112.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8390687985957490189" "False" "High" "IsMasterProtein" "Q5VTR2" "E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2" "0.000" "False" "12.034" "4" "3" "4" "2" "975" "113.6" "5.94" "9.11" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "56254" "ENSG00000155827" "RNF20" "A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83" "E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle" "ATM signaling in development and disease" "3" "0" "1.021" "1.095" "1.366" "1.248" "1.177" "1.064" "0.799" "1.511" "5.548" "52.1" "53.3" "57.1" "71.3" "65.1" "61.4" "55.5" "41.7" "78.8" "289.3" "" "" "" "" "" "" "" "" "" "" "47.1" "41.1" "44.1" "48.0" "54.3" "52.4" "47.1" "30.1" "53.1" "289.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4690988044632206279" "False" "High" "IsMasterProtein" "Q16719" "Kynureninase OS=Homo sapiens OX=9606 GN=KYNU PE=1 SV=1" "0.000" "False" "12.018" "8" "4" "4" "4" "465" "52.3" "7.03" "11.64" "4" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "8942" "ENSG00000115919" "KYNU" "B2RCZ5; D3DP79; hsa:8942; Q16719; Q6I9T2; Q9BVW3" "Tryptophan catabolism" "Selenium micronutrient network; NAD biosynthesis II (from tryptophan); Tryptophan metabolism" "4" "0" "1.037" "1.059" "0.970" "1.037" "1.216" "1.079" "0.983" "1.203" "0.794" "204.1" "211.6" "216.2" "198.0" "211.7" "248.3" "220.3" "200.6" "245.5" "162.1" "" "" "" "" "" "" "" "" "" "" "184.3" "163.3" "167.2" "133.3" "176.6" "211.9" "186.9" "145.2" "165.6" "162.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2050370214376890264" "False" "High" "IsMasterProtein" "O76075" "DNA fragmentation factor subunit beta OS=Homo sapiens OX=9606 GN=DFFB PE=1 SV=1" "0.000" "False" "12.017" "12" "3" "3" "3" "338" "39.1" "9.00" "9.80" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02017, Pf09230" "1677" "ENSG00000169598" "DFFB" "hsa:1677; O60521; O76075; Q5SR22; Q9BYI4; Q9BYI5; Q9BYI6" "Apoptosis induced DNA fragmentation" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "4" "0" "0.949" "0.726" "1.019" "1.020" "0.744" "0.864" "1.054" "0.751" "0.772" "142.4" "135.2" "103.4" "145.2" "145.2" "105.9" "123.1" "150.1" "107.0" "110.0" "" "" "" "" "" "" "" "" "" "" "128.6" "104.3" "80.0" "97.8" "121.2" "90.4" "104.5" "108.6" "72.2" "110.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8339310688111388996" "False" "High" "IsMasterProtein" "Q9HCE5" "N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2" "0.000" "False" "11.996" "8" "3" "4" "3" "456" "52.1" "6.21" "9.53" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "57721" "ENSG00000145388" "METTL14" "A6NIG1; hsa:57721; Q969V2; Q9HCE5" "Processing of Capped Intron-Containing Pre-mRNA" "1p36 copy number variation syndrome" "2" "0" "1.052" "0.934" "1.081" "1.014" "0.938" "0.893" "1.016" "1.049" "0.892" "328.0" "344.9" "306.3" "354.4" "332.5" "307.6" "293.0" "333.2" "344.2" "292.6" "" "" "" "" "" "" "" "" "" "" "296.0" "266.0" "236.9" "238.7" "277.4" "262.6" "248.6" "241.2" "232.1" "292.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8242626749563967556" "False" "High" "IsMasterProtein" "Q9Y606" "Pseudouridylate synthase 1 homolog OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "0.000" "False" "11.994" "12" "5" "5" "5" "427" "47.4" "8.41" "13.93" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "0.880" "1.178" "1.010" "0.879" "1.056" "1.039" "0.333" "1.007" "10.579" "134.6" "118.4" "158.5" "135.9" "118.3" "142.1" "139.7" "44.9" "135.5" "1423.5" "" "" "" "" "" "" "" "" "" "" "121.5" "91.4" "122.6" "91.5" "98.7" "121.3" "118.5" "32.5" "91.4" "1423.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2764493771843335681" "False" "High" "IsMasterProtein" "P08651" "Nuclear factor 1 C-type OS=Homo sapiens OX=9606 GN=NFIC PE=1 SV=2" "0.000" "False" "11.982" "8" "4" "4" "4" "508" "55.6" "8.38" "12.67" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4782" "ENSG00000141905" "NFIC" "A8K1H0; B7Z4U5; B7Z9C3; hsa:4782; K7EMU1; P08651; P08652; Q14932; Q9UPJ3; Q9UPJ9; Q9UPK0; Q9UPK1" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "" "2" "0" "1.067" "1.006" "1.099" "1.013" "0.991" "0.968" "1.017" "0.976" "0.835" "291.0" "310.5" "292.9" "319.9" "294.8" "288.3" "281.7" "295.8" "284.2" "243.0" "" "" "" "" "" "" "" "" "" "" "262.7" "239.5" "226.5" "215.4" "245.9" "246.1" "239.0" "214.1" "191.7" "243.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7154338873387211180" "False" "High" "IsMasterProtein" "Q8TDQ7" "Glucosamine-6-phosphate isomerase 2 OS=Homo sapiens OX=9606 GN=GNPDA2 PE=1 SV=1" "0.000" "False" "11.970" "9" "2" "4" "1" "276" "31.1" "6.95" "8.44" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01182" "132789" "ENSG00000163281" "GNPDA2" "B4DJF3; hsa:132789; Q2VYF1; Q59EA7; Q8NCZ8; Q8TDQ7; Q96BJ4; Q96NC6" "Glycolysis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6037717816811945701" "False" "High" "IsMasterProtein" "Q5T8P6" "RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3" "0.000" "False" "11.954" "4" "4" "5" "4" "1007" "113.5" "9.16" "16.63" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01480" "64062" "ENSG00000139746" "RBM26" "B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7" "" "" "0" "0" "0.914" "1.462" "1.129" "1.014" "1.479" "1.006" "0.916" "1.474" "2.469" "104.5" "95.6" "152.8" "118.0" "106.0" "154.5" "105.1" "95.7" "154.1" "258.0" "" "" "" "" "" "" "" "" "" "" "94.3" "73.7" "118.2" "79.4" "88.4" "131.9" "89.2" "69.3" "103.9" "258.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6782447041087316008" "False" "High" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "0.000" "False" "11.952" "8" "4" "4" "4" "486" "55.7" "5.20" "11.57" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "Clathrin-mediated endocytosis" "" "1" "0" "0.852" "1.286" "0.964" "0.984" "1.063" "0.981" "0.782" "1.341" "2.437" "160.0" "136.4" "205.8" "154.3" "157.5" "170.2" "157.0" "125.2" "214.6" "390.0" "" "" "" "" "" "" "" "" "" "" "144.5" "105.2" "159.2" "103.9" "131.4" "145.2" "133.2" "90.6" "144.8" "390.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1282007746480283530" "False" "High" "IsMasterProtein" "Q9BRJ7" "Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1" "0.000" "False" "11.951" "10" "2" "3" "2" "211" "23.3" "8.91" "8.79" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "" "84309" "ENSG00000168101" "NUDT16L1" "Q8NAI2; Q9BRJ7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7781995361222793159" "False" "High" "IsMasterProtein" "Q9UJX2" "Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3" "0.000" "False" "11.947" "5" "3" "3" "3" "597" "68.8" "7.02" "10.44" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04049" "8697" "ENSG00000094880" "CDC23" "A8K6E5; B4E3A2; B7WP05; D3DQB7; hsa:8697; O75433; Q53FN2; Q9BS73; Q9UJX2" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8283014115765105916" "False" "High" "IsMasterProtein" "Q9UP83" "Conserved oligomeric Golgi complex subunit 5 OS=Homo sapiens OX=9606 GN=COG5 PE=1 SV=4" "0.000" "False" "11.943" "4" "3" "3" "3" "860" "94.8" "6.60" "8.62" "3" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf10392, Pf20649" "10466" "ENSG00000164597" "COG5" "A4D0R6; A4D0R7; hsa:10466; O14555; O95008; Q6NUL5; Q9UP83" "Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport; Intra-Golgi traffic" "" "3" "0" "0.806" "0.936" "0.914" "0.864" "1.035" "0.865" "0.734" "1.008" "5.652" "154.8" "124.8" "144.9" "141.6" "133.7" "160.2" "134.0" "113.7" "156.1" "875.0" "" "" "" "" "" "" "" "" "" "" "139.7" "96.3" "112.0" "95.3" "111.5" "136.7" "113.7" "82.3" "105.3" "875.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106414634070186016" "False" "High" "IsMasterProtein" "Q8WVM8" "Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4" "0.000" "False" "11.941" "5" "4" "6" "4" "642" "72.3" "6.27" "18.71" "4" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00995" "23256" "ENSG00000092108" "SCFD1" "A8K2Z5; B7Z4U7; B7Z594; hsa:23256; O60754; O94990; Q7Z529; Q8WVM8; Q9BZI3; Q9UNL3; Q9Y6A8" "RHOA GTPase cycle; COPII-mediated vesicle transport" "" "2" "0" "0.900" "1.104" "0.857" "1.020" "1.057" "0.918" "0.911" "1.023" "1.411" "252.2" "227.1" "278.4" "216.1" "257.3" "266.4" "231.5" "229.6" "258.0" "355.7" "" "" "" "" "" "" "" "" "" "" "227.6" "175.1" "215.3" "145.5" "214.6" "227.4" "196.4" "166.2" "174.0" "355.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3786369172385558853" "False" "High" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "0.000" "False" "11.922" "17" "4" "7" "4" "210" "24.5" "5.95" "19.55" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "1.011" "0.975" "0.973" "0.977" "0.988" "1.005" "0.976" "1.022" "1.423" "332.7" "336.4" "324.2" "323.8" "325.0" "328.7" "334.5" "324.6" "339.8" "473.5" "" "" "" "" "" "" "" "" "" "" "300.3" "259.5" "250.8" "218.1" "271.1" "280.6" "283.7" "234.9" "229.2" "473.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5167676998188788346" "False" "High" "IsMasterProtein" "Q96EV2" "RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3" "0.000" "False" "11.915" "2" "2" "3" "2" "1170" "129.9" "6.93" "10.26" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "155435" "ENSG00000184863" "RBM33" "A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0" "" "" "0" "0" "1.113" "0.863" "1.093" "1.038" "0.868" "1.187" "0.882" "0.882" "1.450" "60.9" "67.8" "52.6" "66.6" "63.2" "52.9" "72.3" "53.7" "53.7" "88.3" "" "" "" "" "" "" "" "" "" "" "55.0" "52.3" "40.7" "44.8" "52.7" "45.1" "61.3" "38.9" "36.2" "88.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832137807520605002" "False" "High" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "0.000" "False" "11.908" "4" "3" "3" "3" "754" "84.9" "6.90" "10.06" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf00533, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "29" "0" "1.067" "0.918" "1.211" "1.020" "0.790" "1.126" "0.994" "1.031" "1.918" "173.0" "184.5" "158.8" "209.4" "176.4" "136.6" "194.9" "172.0" "178.3" "331.8" "" "" "" "" "" "" "" "" "" "" "156.2" "142.3" "122.8" "141.0" "147.1" "116.6" "165.3" "124.5" "120.3" "331.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3725615404801325538" "False" "High" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=5" "0.000" "False" "11.899" "7" "4" "4" "4" "565" "63.1" "5.72" "11.26" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13181" "" "ENSG00000196510" "ANAPC7" "Q96AC4; Q96GF4; Q9BU24; Q9NT16; Q9UJX3" "Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.529" "0.863" "1.531" "1.270" "1.191" "1.366" "1.146" "0.895" "1.553" "11.3" "17.3" "9.8" "17.3" "14.4" "13.5" "15.5" "13.0" "10.1" "17.6" "" "" "" "" "" "" "" "" "" "" "10.2" "13.4" "7.6" "11.7" "12.0" "11.5" "13.1" "9.4" "6.8" "17.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8788472230308956" "False" "High" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "0.000" "False" "11.891" "12" "3" "8" "3" "288" "31.7" "7.66" "13.75" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "Nicotinamide salvaging" "" "1" "0" "0.964" "0.993" "1.143" "0.743" "1.087" "1.031" "0.986" "0.730" "0.703" "172.0" "165.8" "170.8" "196.6" "127.9" "187.1" "177.4" "169.6" "125.6" "121.0" "" "" "" "" "" "" "" "" "" "" "155.3" "127.9" "132.1" "132.4" "106.7" "159.7" "150.5" "122.8" "84.7" "121.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5091177938667012153" "False" "High" "IsMasterProtein" "P41743" "Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2" "0.000" "False" "11.890" "7" "3" "4" "3" "596" "68.2" "5.85" "11.78" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5584" "ENSG00000163558" "PRKCI" "D3DNQ4; hsa:5584; P41743; Q8WW06" "KEAP1-NFE2L2 pathway; Tight junction interactions; Pre-NOTCH Transcription and Translation; p75NTR recruits signalling complexes" "Glioblastoma signaling pathways; Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Chronic hyperglycemia impairment of neuron function" "15" "0" "1.273" "1.169" "1.087" "1.184" "1.150" "1.421" "1.217" "1.066" "1.186" "108.1" "137.7" "126.5" "117.5" "128.1" "124.4" "153.7" "131.6" "115.2" "128.3" "" "" "" "" "" "" "" "" "" "" "97.6" "106.2" "97.8" "79.1" "106.8" "106.1" "130.4" "95.2" "77.7" "128.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6526691587198802025" "False" "High" "IsMasterProtein" "P59780" "AP-3 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP3S2 PE=1 SV=1" "0.000" "False" "11.882" "16" "3" "3" "3" "193" "22.0" "5.22" "10.06" "3" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "10239" "ENSG00000157823" "AP3S2" "B2R677; B4DGQ3; hsa:10239; O09077; O09149; P59780; Q53H83; Q99589" "" "" "0" "0" "0.929" "0.835" "1.076" "0.979" "0.701" "1.018" "1.012" "0.794" "1.238" "213.2" "198.0" "178.0" "229.5" "208.8" "149.6" "217.0" "215.7" "169.2" "264.1" "" "" "" "" "" "" "" "" "" "" "192.5" "152.7" "137.7" "154.5" "174.2" "127.6" "184.1" "156.1" "114.1" "264.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "882715983706929749" "False" "High" "IsMasterProtein" "Q9NZ08" "Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3" "0.000" "False" "11.854" "4" "4" "4" "4" "941" "107.2" "6.46" "11.81" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01433, Pf11838, Pf17900" "51752" "ENSG00000164307" "ERAP1" "hsa:51752; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9NZ08; Q9UHF8; Q9UKY2" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "" "1" "0" "1.634" "1.294" "1.282" "1.253" "1.530" "1.214" "0.890" "1.433" "2.237" "91.6" "149.7" "118.5" "117.4" "114.8" "140.1" "111.2" "81.5" "131.2" "204.9" "" "" "" "" "" "" "" "" "" "" "82.7" "115.4" "91.7" "79.0" "95.8" "119.6" "94.3" "59.0" "88.5" "204.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2715683272122769400" "False" "High" "IsMasterProtein" "Q14197" "Large ribosomal subunit protein mL62 OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" "0.000" "False" "11.852" "15" "3" "3" "3" "206" "23.6" "10.07" "9.96" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00472" "3396" "ENSG00000167862" "MRPL58" "B2RAD1; hsa:3396; Q14197; Q53HM7; Q53Y11" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.916" "0.849" "0.782" "0.904" "0.847" "0.948" "0.907" "0.811" "0.861" "282.6" "258.9" "239.8" "221.0" "255.4" "239.4" "267.9" "256.3" "229.0" "243.4" "" "" "" "" "" "" "" "" "" "" "255.1" "199.7" "185.5" "148.8" "213.1" "204.4" "227.3" "185.5" "154.5" "243.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153241618277291639" "False" "High" "IsMasterProtein" "Q9ULK4" "Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2" "0.000" "False" "11.851" "2" "3" "4" "3" "1368" "156.4" "7.40" "14.01" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11573" "9439" "ENSG00000112282" "MED23" "B9TX55; hsa:9439; O95403; Q5JWT3; Q5JWT4; Q6P9H6; Q9H0J2; Q9NTT9; Q9NTU0; Q9ULK4; Q9Y5P7; Q9Y667" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "0.972" "0.919" "0.993" "1.005" "0.858" "0.983" "0.946" "0.911" "0.895" "453.1" "440.6" "416.4" "450.2" "455.6" "389.0" "445.6" "428.8" "412.9" "405.8" "" "" "" "" "" "" "" "" "" "" "409.0" "339.8" "322.1" "303.1" "380.0" "332.0" "378.0" "310.3" "278.5" "405.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8652321965736247269" "False" "High" "IsMasterProtein" "Q8TCA0" "Leucine-rich repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=LRRC20 PE=1 SV=1" "0.000" "False" "11.849" "15" "2" "2" "2" "184" "20.5" "6.55" "8.67" "2" "" "" "" "Pf13855" "55222" "ENSG00000172731" "LRRC20" "hsa:55222; Q5T6D4; Q5T6D6; Q8TCA0; Q9NVA6; Q9NVG3" "" "" "0" "0" "1.245" "0.745" "1.146" "1.084" "1.021" "1.051" "1.065" "1.035" "0.982" "44.4" "55.3" "33.1" "50.9" "48.1" "45.3" "46.6" "47.3" "46.0" "43.6" "" "" "" "" "" "" "" "" "" "" "40.1" "42.6" "25.6" "34.2" "40.1" "38.7" "39.6" "34.2" "31.0" "43.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "353320057128082956" "False" "High" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "0.000" "False" "11.832" "14" "3" "4" "3" "221" "25.5" "8.65" "14.07" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "1.018" "1.080" "1.021" "1.040" "1.025" "1.055" "1.033" "0.986" "1.537" "366.6" "373.1" "395.9" "374.3" "381.1" "375.7" "386.7" "378.7" "361.3" "563.5" "" "" "" "" "" "" "" "" "" "" "330.9" "287.8" "306.2" "252.1" "317.9" "320.7" "328.0" "274.1" "243.7" "563.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7162742285351111146" "False" "High" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "0.000" "False" "11.827" "4" "3" "5" "3" "715" "80.7" "9.26" "17.26" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "Effect of progerin on genes involved in progeria; TAR syndrome" "8" "0" "0.886" "1.585" "1.042" "1.057" "1.544" "0.883" "0.967" "1.472" "2.159" "234.3" "207.5" "371.4" "244.1" "247.5" "361.6" "206.9" "226.6" "344.8" "505.7" "" "" "" "" "" "" "" "" "" "" "211.5" "160.1" "287.3" "164.4" "206.5" "308.6" "175.5" "164.0" "232.6" "505.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957461368778197343" "False" "High" "IsMasterProtein" "Q96I51" "RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=3" "0.000" "False" "11.793" "9" "4" "4" "4" "464" "49.9" "8.29" "12.07" "4" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415, Pf13540" "81554" "ENSG00000274523" "RCC1L" "D3DXK0; F5GX55; F5H6C7; hsa:81554; Q548B1; Q8IW88; Q8N572; Q96I51; Q9H0G7" "" "" "0" "0" "1.032" "1.024" "1.078" "1.173" "1.063" "1.012" "1.112" "1.078" "1.040" "138.5" "142.9" "141.8" "149.3" "162.4" "147.2" "140.1" "153.9" "149.3" "144.0" "" "" "" "" "" "" "" "" "" "" "125.0" "110.2" "109.7" "100.5" "135.5" "125.7" "118.9" "111.4" "100.7" "144.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2661255315618113722" "False" "High" "IsMasterProtein" "O43493" "Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4" "0.000" "False" "11.785" "3" "1" "2" "1" "437" "45.9" "5.63" "7.83" "1" "" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "" "Pf17818" "10618" "ENSG00000152291; ENSG00000292253" "TGOLN2" "B2R686; B8ZZ88; D6W5K3; F8W8W7; F8WBK2; hsa:10618; J3KQ45; O15282; O43492; O43493; O43499; O43500; O43501; Q53G68; Q53GV2; Q6MZV1; Q6ZTM7; Q8N6T8; Q92760; Q96QL2" "Golgi Associated Vesicle Biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "" "6" "0" "0.891" "0.991" "0.957" "0.870" "1.020" "1.096" "0.955" "1.046" "0.908" "58.1" "51.8" "57.6" "55.6" "50.6" "59.3" "63.7" "55.5" "60.8" "52.8" "" "" "" "" "" "" "" "" "" "" "52.5" "40.0" "44.6" "37.5" "42.2" "50.6" "54.1" "40.2" "41.0" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538094465215650253" "False" "High" "IsMasterProtein" "Q8N4J0" "Carnosine N-methyltransferase OS=Homo sapiens OX=9606 GN=CARNMT1 PE=1 SV=1" "0.000" "False" "11.783" "11" "5" "5" "5" "409" "47.2" "6.32" "13.76" "5" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07942" "138199" "ENSG00000156017" "CARNMT1" "hsa:138199; Q7Z383; Q8N4J0; Q8N7C5" "Histidine catabolism" "" "1" "0" "0.944" "0.958" "0.887" "0.991" "0.977" "0.993" "0.970" "1.030" "0.815" "309.7" "292.3" "296.8" "274.6" "306.8" "302.6" "307.5" "300.3" "318.9" "252.4" "" "" "" "" "" "" "" "" "" "" "279.5" "225.5" "229.6" "184.9" "255.9" "258.3" "260.8" "217.3" "215.1" "252.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2379782774127482569" "False" "High" "IsMasterProtein" "Q86YM7" "Homer protein homolog 1 OS=Homo sapiens OX=9606 GN=HOMER1 PE=1 SV=2" "0.000" "False" "11.732" "12" "4" "4" "4" "354" "40.3" "5.44" "13.09" "4" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9456" "ENSG00000152413" "HOMER1" "B2R688; hsa:9456; O96003; Q86YM5; Q86YM7" "Neurexins and neuroligins" "BDNF-TrkB signaling; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; Orexin receptor pathway; Cell lineage map for neuronal differentiation" "7" "0" "0.956" "0.744" "0.938" "0.922" "0.900" "0.933" "0.944" "0.787" "0.879" "182.7" "174.8" "136.0" "171.5" "168.4" "164.4" "170.5" "172.5" "143.8" "160.6" "" "" "" "" "" "" "" "" "" "" "165.0" "134.8" "105.2" "115.5" "140.5" "140.4" "144.6" "124.9" "97.0" "160.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1711766393091945325" "False" "High" "IsMasterProtein" "Q6DKK2" "Tetratricopeptide repeat protein 19, mitochondrial OS=Homo sapiens OX=9606 GN=TTC19 PE=1 SV=4" "0.000" "False" "11.702" "5" "2" "3" "2" "380" "42.4" "5.77" "9.52" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;cytoskeleton;mitochondrion;other cell component" "" "Pf13374, Pf13424" "54902" "ENSG00000011295" "TTC19" "A8MZ52; B3KP62; B4DN65; hsa:54902; Q2M248; Q6DKK2; Q7L3U8; Q9H6G3; Q9NXB2" "" "Mitochondrial complex III assembly" "1" "0" "0.649" "0.742" "0.809" "0.802" "0.785" "0.682" "0.607" "1.009" "0.821" "32.9" "21.4" "24.4" "26.6" "26.4" "25.8" "22.4" "20.0" "33.2" "27.0" "" "" "" "" "" "" "" "" "" "" "29.7" "16.5" "18.9" "17.9" "22.0" "22.0" "19.0" "14.4" "22.4" "27.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519156847082484659" "False" "High" "IsMasterProtein" "Q16695" "Histone H3.1t OS=Homo sapiens OX=9606 GN=H3-4 PE=1 SV=3" "0.000" "False" "11.702" "24" "4" "18" "1" "136" "15.5" "11.12" "58.82" "4" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8290" "ENSG00000168148; ENSG00000285435" "H3-4" "B2R5K3; hsa:8290; Q16695; Q6FGU4" "Meiotic synapsis; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ)" "Follicle stimulating hormone (FSH) signaling pathway; Male infertility" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2873393245892861627" "False" "High" "IsMasterProtein" "Q9UI15" "Transgelin-3 OS=Homo sapiens OX=9606 GN=TAGLN3 PE=1 SV=2" "0.000" "False" "11.696" "14" "2" "7" "1" "199" "22.5" "7.33" "19.61" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf00307, Pf00402" "29114" "ENSG00000144834" "TAGLN3" "D3DN64; hsa:29114; Q96A74; Q9UI15" "" "" "0" "0" "0.904" "0.922" "1.268" "0.873" "0.833" "0.897" "0.902" "0.890" "1.074" "51.8" "46.8" "47.8" "65.7" "45.2" "43.2" "46.5" "46.7" "46.1" "55.6" "" "" "" "" "" "" "" "" "" "" "46.8" "36.1" "37.0" "44.2" "37.7" "36.8" "39.4" "33.8" "31.1" "55.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4012099030302879857" "False" "High" "IsMasterProtein" "P49137" "MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1" "0.000" "False" "11.691" "10" "5" "6" "3" "400" "45.5" "8.68" "15.06" "5" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9261" "ENSG00000162889" "MAPKAPK2" "hsa:9261; P49137; Q5SY30; Q5SY41; Q8IYD6" "VEGFA-VEGFR2 Pathway; Regulation of HSF1-mediated heat shock response; Oxidative Stress Induced Senescence; Regulation of TNFR1 signaling; p38MAPK events; activated TAK1 mediates p38 MAPK activation; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Pleural mesothelioma; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "21" "1" "0.989" "0.898" "0.952" "0.893" "0.916" "0.926" "0.959" "0.918" "0.983" "526.3" "520.4" "472.5" "500.9" "469.8" "482.0" "487.6" "504.7" "483.3" "517.3" "" "" "" "" "" "" "" "" "" "" "475.1" "401.4" "365.5" "337.3" "391.9" "411.4" "413.6" "365.2" "326.0" "517.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8778470671322458913" "False" "High" "IsMasterProtein" "Q71UI9" "Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3" "0.000" "False" "11.676" "20" "3" "8" "1" "128" "13.5" "10.58" "20.45" "3" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "94239" "ENSG00000105968" "H2AZ2" "A6NFA8; A6NKY0; A6NN01; A8MQC5; hsa:94239; Q59GV8; Q6PK98; Q71UI9" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "35" "0" "1.168" "1.130" "1.016" "1.142" "1.265" "1.007" "1.022" "1.140" "2.620" "193.0" "225.4" "218.1" "196.0" "220.4" "244.2" "194.2" "197.3" "220.0" "505.7" "" "" "" "" "" "" "" "" "" "" "174.2" "173.8" "168.6" "132.0" "183.8" "208.4" "164.8" "142.8" "148.4" "505.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5304133680658965036" "False" "High" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "0.000" "False" "11.674" "21" "5" "6" "4" "238" "27.4" "11.82" "15.16" "5" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "7" "1" "0.963" "1.122" "1.179" "1.074" "1.057" "1.023" "0.915" "1.065" "1.229" "406.2" "391.2" "455.9" "478.8" "436.4" "429.5" "415.5" "371.7" "432.4" "499.3" "" "" "" "" "" "" "" "" "" "" "366.6" "301.7" "352.6" "322.4" "364.0" "366.6" "352.5" "269.0" "291.7" "499.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2707692795518285071" "False" "High" "IsMasterProtein" "Q567U6" "Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2" "0.000" "False" "11.673" "6" "3" "3" "3" "631" "73.2" "8.15" "6.48" "3" "transport" "other cytoplasmic organelle;other cell component" "" "Pf09762, Pf21673" "54520" "ENSG00000125633" "CCDC93" "A8K3V7; hsa:54520; Q4LE78; Q53TJ2; Q567U6; Q8TBX5; Q9H6R5; Q9NV15" "" "" "0" "0" "1.059" "0.759" "1.026" "1.023" "0.858" "0.956" "0.923" "0.751" "1.414" "57.4" "60.8" "43.6" "58.9" "58.8" "49.3" "54.9" "53.0" "43.2" "81.2" "" "" "" "" "" "" "" "" "" "" "51.8" "46.9" "33.7" "39.7" "49.0" "42.1" "46.6" "38.4" "29.1" "81.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3870745537767616027" "False" "High" "IsMasterProtein" "Q9UKT9" "Zinc finger protein Aiolos OS=Homo sapiens OX=9606 GN=IKZF3 PE=1 SV=2" "0.000" "False" "11.668" "8" "4" "4" "2" "509" "58.0" "6.55" "10.16" "4" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "22806" "ENSG00000161405" "IKZF3" "B4DVV5; hsa:22806; Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2; Q69BM3; Q69BM5; Q8N574; Q8WWQ9; Q8WWR0; Q8WWR1; Q8WWR2; Q8WWR3; Q9UKT9" "" "17q12 copy number variation syndrome" "1" "0" "0.629" "0.778" "1.024" "1.002" "0.754" "0.912" "0.528" "0.802" "7.671" "9.9" "6.3" "7.7" "10.2" "10.0" "7.5" "9.1" "5.3" "8.0" "76.3" "" "" "" "" "" "" "" "" "" "" "9.0" "4.8" "6.0" "6.9" "8.3" "6.4" "7.7" "3.8" "5.4" "76.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2017591020137158396" "False" "High" "IsMasterProtein" "O14966" "Ras-related protein Rab-7L1 OS=Homo sapiens OX=9606 GN=RAB29 PE=1 SV=1" "0.000" "False" "11.655" "9" "2" "3" "1" "203" "23.1" "7.18" "9.64" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "8934" "ENSG00000117280" "RAB29" "B4E1K3; C9JE77; hsa:8934; O14966" "RAB geranylgeranylation" "" "1" "0" "0.863" "0.855" "0.752" "0.973" "0.974" "0.908" "0.875" "0.920" "0.713" "114.1" "98.4" "97.5" "85.8" "111.0" "111.2" "103.6" "99.8" "104.9" "81.3" "" "" "" "" "" "" "" "" "" "" "103.0" "75.9" "75.4" "57.8" "92.6" "94.9" "87.9" "72.2" "70.8" "81.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2580326738670543746" "False" "High" "IsMasterProtein" "O60341" "Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2" "0.000" "False" "11.638" "3" "3" "3" "3" "852" "92.8" "6.52" "9.96" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01593, Pf04433" "23028" "ENSG00000004487" "KDM1A" "A8MWP9; hsa:23028; O60341; Q5TH94; Q5TH95; Q86VT7; Q8IXK4; Q8NDP6; Q8TAZ3; Q96AW4" "Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "Androgen receptor signaling pathway; Effect of progerin on genes involved in progeria; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Neurogenesis regulation in the olfactory epithelium" "14" "0" "0.930" "0.717" "0.898" "0.863" "0.729" "0.736" "0.802" "0.710" "1.776" "210.0" "195.3" "150.5" "188.5" "181.2" "153.1" "154.6" "168.5" "149.2" "372.9" "" "" "" "" "" "" "" "" "" "" "189.5" "150.7" "116.4" "126.9" "151.2" "130.7" "131.1" "121.9" "100.6" "372.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490107994498796069" "False" "High" "IsMasterProtein" "Q8WVC0" "RNA polymerase-associated protein LEO1 OS=Homo sapiens OX=9606 GN=LEO1 PE=1 SV=1" "0.000" "False" "11.638" "3" "3" "3" "3" "666" "75.4" "4.51" "8.53" "3" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf04004" "123169" "ENSG00000166477" "LEO1" "hsa:123169; Q8WVC0; Q96N99" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex" "Endoderm differentiation" "6" "0" "0.903" "1.255" "1.178" "1.081" "1.209" "0.991" "0.890" "1.341" "3.272" "224.0" "202.3" "281.2" "264.0" "242.1" "270.8" "222.0" "199.3" "300.4" "733.0" "" "" "" "" "" "" "" "" "" "" "202.2" "156.1" "217.5" "177.8" "202.0" "231.1" "188.3" "144.2" "202.6" "733.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7489520263377738348" "False" "High" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "0.000" "False" "11.627" "6" "2" "2" "2" "357" "39.3" "8.10" "7.33" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "mRNA processing" "3" "0" "1.108" "1.157" "1.166" "1.139" "1.126" "1.014" "0.925" "1.037" "0.718" "111.6" "123.6" "129.0" "130.1" "127.0" "125.6" "113.1" "103.1" "115.7" "80.2" "" "" "" "" "" "" "" "" "" "" "100.7" "95.3" "99.8" "87.6" "106.0" "107.2" "95.9" "74.6" "78.1" "80.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9194827022255966282" "False" "High" "IsMasterProtein" "Q9C0J8" "pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2" "0.000" "False" "11.584" "3" "4" "5" "4" "1336" "145.8" "9.17" "15.38" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf01391" "55339" "ENSG00000136709" "WDR33" "hsa:55339; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9C0J8; Q9NUL1" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript" "" "5" "0" "1.133" "1.681" "1.101" "1.247" "1.643" "0.980" "0.935" "1.552" "0.943" "138.2" "156.6" "232.3" "152.2" "172.4" "227.1" "135.4" "129.3" "214.5" "130.3" "" "" "" "" "" "" "" "" "" "" "124.8" "120.8" "179.7" "102.5" "143.8" "193.9" "114.9" "93.6" "144.7" "130.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7201160367223049830" "False" "High" "IsMasterProtein" "Cont_Q3MHN5" "Vitamin D-binding protein OS=Bos taurus OX=9913 GN=GC PE=2 SV=1" "0.000" "True" "11.577" "7" "4" "4" "4" "474" "53.3" "5.52" "11.17" "4" "transport" "non-structural extracellular;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00273, Pf09164" "530076" "" "GC" "bta:530076; Q3MHN5" "" "" "0" "0" "1.212" "1.283" "1.244" "1.129" "1.471" "1.118" "1.049" "1.838" "0.927" "166.7" "202.1" "213.9" "207.3" "188.1" "245.2" "186.4" "174.8" "306.4" "154.5" "" "" "" "" "" "" "" "" "" "" "150.5" "155.9" "165.5" "139.6" "156.9" "209.3" "158.1" "126.5" "206.6" "154.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7864399280568064191" "False" "High" "IsMasterProtein" "Q9BT23" "LIM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LIMD2 PE=1 SV=1" "0.000" "False" "11.570" "24" "4" "7" "3" "127" "14.1" "9.03" "20.44" "4" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "80774" "ENSG00000136490" "LIMD2" "D3DU16; hsa:80774; Q96S91; Q9BT23" "" "" "0" "0" "1.027" "0.949" "1.057" "0.965" "1.030" "1.056" "1.163" "1.054" "0.706" "319.4" "328.1" "303.2" "337.6" "308.1" "328.9" "337.1" "371.4" "336.7" "225.4" "" "" "" "" "" "" "" "" "" "" "288.3" "253.1" "234.5" "227.3" "257.0" "280.7" "286.0" "268.8" "227.1" "225.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188184621199488866" "False" "High" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "0.000" "False" "11.570" "30" "3" "3" "3" "109" "12.3" "10.24" "9.49" "3" "other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "Mitochondrial RNA degradation" "" "1" "0" "1.172" "1.199" "1.026" "0.990" "1.132" "1.182" "1.084" "1.076" "3.038" "63.4" "74.4" "76.1" "65.1" "62.8" "71.8" "75.0" "68.7" "68.3" "192.7" "" "" "" "" "" "" "" "" "" "" "57.3" "57.4" "58.8" "43.8" "52.4" "61.3" "63.6" "49.7" "46.0" "192.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825155014730555615" "False" "High" "IsMasterProtein" "Q6GMV2" "Histone-lysine N-trimethyltransferase SMYD5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2" "0.000" "False" "11.550" "6" "3" "4" "3" "418" "47.3" "5.05" "12.28" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "" "other molecular function" "Pf00856" "10322" "ENSG00000135632" "SMYD5" "D6W5H3; hsa:10322; Q13558; Q6GMV2" "" "Histone modifications" "1" "0" "1.001" "1.073" "1.462" "1.082" "1.224" "1.416" "1.291" "1.020" "0.825" "41.6" "41.6" "44.6" "60.8" "45.0" "50.9" "58.9" "53.7" "42.4" "34.3" "" "" "" "" "" "" "" "" "" "" "37.5" "32.1" "34.5" "40.9" "37.5" "43.4" "49.9" "38.8" "28.6" "34.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8461791288305677895" "False" "High" "IsMasterProtein" "Q92783" "Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3" "0.000" "False" "11.542" "7" "4" "4" "3" "540" "59.1" "4.82" "12.29" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "8027" "ENSG00000136738" "STAM" "B0YJ99; D3DRU5; hsa:8027; Q8N6D9; Q92783" "Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Metalloprotease DUBs; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "Vitamin D receptor pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "11" "0" "0.894" "1.088" "0.850" "1.051" "0.976" "0.948" "0.940" "1.093" "0.777" "53.9" "48.2" "58.6" "45.8" "56.7" "52.6" "51.1" "50.7" "58.9" "41.9" "" "" "" "" "" "" "" "" "" "" "48.6" "37.2" "45.3" "30.9" "47.3" "44.9" "43.4" "36.7" "39.7" "41.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5255338936326354588" "False" "High" "IsMasterProtein" "O75448" "Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1" "0.000" "False" "11.539" "2" "2" "2" "2" "989" "110.2" "6.95" "8.08" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11277" "9862" "ENSG00000008838" "MED24" "A8K4S5; B3KMR9; hsa:9862; O75448; Q14143; Q9NNY5" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "0.957" "1.034" "1.000" "1.089" "0.891" "0.956" "1.059" "1.006" "0.923" "140.5" "134.4" "145.4" "140.6" "153.0" "125.2" "134.4" "148.9" "141.3" "129.7" "" "" "" "" "" "" "" "" "" "" "126.9" "103.7" "112.4" "94.7" "127.6" "106.9" "114.0" "107.7" "95.3" "129.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6553224162090552303" "False" "High" "IsMasterProtein" "Q9Y3A3" "MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1" "0.000" "False" "11.532" "11" "2" "2" "2" "225" "26.0" "5.78" "6.03" "2" "" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03637" "25843" "ENSG00000115540" "MOB4" "B4DML0; hsa:25843; Q53SE0; Q7Z4Y6; Q9H2P3; Q9H5J1; Q9Y3A3; Q9Y4T8" "" "" "0" "0" "1.164" "1.195" "0.923" "1.150" "1.204" "1.043" "0.968" "1.121" "0.709" "78.3" "91.1" "93.5" "72.3" "90.0" "94.2" "81.6" "75.7" "87.7" "55.5" "" "" "" "" "" "" "" "" "" "" "70.6" "70.3" "72.3" "48.7" "75.1" "80.4" "69.2" "54.8" "59.2" "55.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327789120096563661" "False" "High" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "0.000" "False" "11.518" "9" "4" "5" "4" "388" "41.8" "8.90" "16.66" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "" "Adipogenesis" "1" "0" "0.946" "0.710" "0.953" "0.969" "0.720" "0.993" "1.007" "0.730" "0.793" "481.5" "455.4" "342.0" "458.9" "466.5" "346.7" "478.1" "484.8" "351.6" "381.7" "" "" "" "" "" "" "" "" "" "" "434.6" "351.3" "264.5" "309.0" "389.1" "295.9" "405.6" "350.8" "237.2" "381.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8700335326144916466" "False" "High" "IsMasterProtein" "Q9UET6" "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "0.000" "False" "11.517" "10" "3" "4" "3" "329" "36.1" "5.69" "12.74" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.009" "0.853" "1.110" "0.996" "0.944" "1.046" "1.042" "0.940" "1.074" "304.6" "307.2" "259.8" "338.2" "303.4" "287.7" "318.7" "317.5" "286.4" "327.0" "" "" "" "" "" "" "" "" "" "" "275.0" "237.0" "200.9" "227.8" "253.1" "245.6" "270.4" "229.8" "193.2" "327.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8244788051015200479" "False" "High" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "0.000" "False" "11.517" "24" "5" "10" "4" "177" "19.2" "8.07" "16.79" "5" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "" "2" "0" "0.993" "1.270" "0.841" "0.886" "0.948" "0.970" "1.210" "1.043" "1.079" "43.9" "43.6" "55.8" "36.9" "38.9" "41.6" "42.6" "53.1" "45.8" "47.4" "" "" "" "" "" "" "" "" "" "" "39.6" "33.6" "43.1" "24.9" "32.5" "35.5" "36.2" "38.5" "30.9" "47.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7438164124212550785" "False" "High" "IsMasterProtein" "Q96EV8" "Dysbindin OS=Homo sapiens OX=9606 GN=DTNBP1 PE=1 SV=1" "0.000" "False" "11.514" "7" "2" "2" "2" "351" "39.5" "4.67" "7.73" "2" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04440" "84062" "ENSG00000047579" "DTNBP1" "A8K3V3; hsa:84062; Q5THY3; Q5THY4; Q96EV8; Q96NV2; Q9H0U2; Q9H3J5" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "0.965" "0.584" "0.855" "0.884" "0.698" "0.883" "0.929" "0.573" "0.749" "116.3" "112.2" "67.8" "99.4" "102.7" "81.1" "102.6" "108.1" "66.6" "87.0" "" "" "" "" "" "" "" "" "" "" "105.0" "86.5" "52.5" "66.9" "85.7" "69.2" "87.1" "78.2" "44.9" "87.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946118222351064345" "False" "High" "IsMasterProtein" "Q6DD87" "Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4" "0.000" "False" "11.511" "4" "1" "2" "1" "382" "40.4" "7.96" "7.91" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465, Pf13912" "126208" "ENSG00000142409" "ZNF787" "A0A087WUD1; hsa:126208; O00455; Q6DD87" "" "" "0" "0" "1.008" "1.022" "1.086" "1.063" "1.054" "1.005" "1.109" "1.074" "0.733" "112.3" "113.2" "114.8" "121.9" "119.4" "118.4" "112.9" "124.6" "120.7" "82.4" "" "" "" "" "" "" "" "" "" "" "101.4" "87.3" "88.8" "82.1" "99.6" "101.0" "95.8" "90.1" "81.4" "82.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8991968867262954800" "False" "High" "IsMasterProtein" "Q9P2K8" "eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3" "0.000" "False" "11.497" "2" "4" "4" "4" "1649" "186.8" "6.28" "11.42" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf05773, Pf12745, Pf13393" "440275" "ENSG00000128829" "EIF2AK4" "C9JEC4; hsa:440275; Q69YL7; Q6DC97; Q96GN6; Q9H5K1; Q9NSQ3; Q9NSZ5; Q9P2K8; Q9UJ56" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "Measles virus infection" "2" "0" "1.039" "0.898" "0.969" "0.968" "0.964" "0.929" "0.854" "0.985" "1.834" "202.2" "210.1" "181.7" "195.9" "195.7" "194.9" "187.8" "172.7" "199.1" "370.8" "" "" "" "" "" "" "" "" "" "" "182.5" "162.1" "140.5" "131.9" "163.2" "166.3" "159.3" "125.0" "134.3" "370.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711060710327679778" "False" "High" "IsMasterProtein" "O75886" "Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1" "0.000" "False" "11.483" "4" "2" "3" "1" "525" "58.1" "5.07" "9.53" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "10254" "ENSG00000115145" "STAM2" "A8K8A0; D3DPA1; hsa:10254; O75886; Q7LDQ0; Q9UF58" "Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "EGF/EGFR signaling pathway" "9" "0" "1.556" "1.493" "1.188" "1.346" "1.516" "1.264" "1.524" "1.837" "2.288" "12.5" "19.4" "18.6" "14.8" "16.8" "18.9" "15.8" "19.0" "22.9" "28.5" "" "" "" "" "" "" "" "" "" "" "11.3" "15.0" "14.4" "10.0" "14.0" "16.1" "13.4" "13.8" "15.5" "28.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2014146262064774288" "False" "High" "IsMasterProtein" "P09001" "Large ribosomal subunit protein uL3m OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "0.000" "False" "11.483" "6" "2" "2" "2" "348" "38.6" "9.48" "7.67" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.962" "0.764" "0.926" "0.940" "0.763" "0.941" "0.796" "0.863" "1.092" "296.1" "284.8" "226.2" "274.2" "278.3" "226.0" "278.6" "235.6" "255.6" "323.2" "" "" "" "" "" "" "" "" "" "" "267.3" "219.7" "174.9" "184.6" "232.2" "192.9" "236.3" "170.5" "172.4" "323.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939925399894006679" "False" "High" "IsMasterProtein" "Q9NWU2" "Glucose-induced degradation protein 8 homolog OS=Homo sapiens OX=9606 GN=GID8 PE=1 SV=1" "0.000" "False" "11.482" "17" "2" "2" "2" "228" "26.7" "4.97" "7.79" "2" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08513, Pf10607" "54994" "ENSG00000101193" "GID8" "E1P5I3; hsa:54994; Q8N5M5; Q9NWU2" "" "Ciliary landscape" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1054037842820128470" "False" "High" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "0.000" "False" "11.458" "10" "1" "1" "1" "252" "25.4" "9.88" "6.47" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "0.827" "1.111" "0.773" "1.025" "0.994" "1.274" "1.202" "0.922" "1.069" "29.3" "24.2" "32.5" "22.6" "30.0" "29.1" "37.3" "35.2" "27.0" "31.3" "" "" "" "" "" "" "" "" "" "" "26.4" "18.7" "25.1" "15.2" "25.0" "24.8" "31.6" "25.4" "18.2" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869827592286108947" "False" "High" "IsMasterProtein" "Q9UPQ9" "Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4" "0.000" "False" "11.449" "2" "2" "4" "2" "1833" "193.9" "6.76" "8.44" "2" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10427, Pf16608" "23112" "ENSG00000100354" "TNRC6B" "B0QY73; B0QY78; B4DGC0; hsa:23112; Q5TH52; Q8TBX2; Q9UPQ9" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "" "18" "0" "1.305" "1.898" "1.689" "1.332" "1.627" "1.286" "1.566" "1.608" "1.203" "24.7" "32.2" "46.8" "41.6" "32.8" "40.1" "31.7" "38.6" "39.6" "29.6" "" "" "" "" "" "" "" "" "" "" "22.3" "24.8" "36.2" "28.0" "27.4" "34.2" "26.9" "27.9" "26.7" "29.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710541814749781042" "False" "High" "IsMasterProtein" "P54619" "5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1" "0.000" "False" "11.425" "10" "4" "4" "4" "331" "37.6" "6.92" "11.56" "4" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00571" "5571" "ENSG00000181929" "PRKAG1" "B4DDT7; hsa:5571; P54619; Q8N7V9" "Regulation of TP53 Activity through Phosphorylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "24" "0" "0.929" "0.982" "0.974" "0.864" "0.975" "0.883" "0.900" "1.024" "1.154" "119.2" "110.7" "117.0" "116.1" "102.9" "116.2" "105.2" "107.3" "122.1" "137.6" "" "" "" "" "" "" "" "" "" "" "107.6" "85.4" "90.5" "78.1" "85.9" "99.2" "89.3" "77.7" "82.3" "137.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786951349264090061" "False" "High" "IsMasterProtein" "Q9P2I0" "Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2" "0.000" "False" "11.411" "4" "3" "3" "3" "782" "88.4" "5.11" "8.81" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07521, Pf10996, Pf13299, Pf16661" "53981" "ENSG00000165934" "CPSF2" "B3KME1; hsa:53981; Q6NSJ1; Q9H3W7; Q9P2I0" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "0.999" "1.260" "1.251" "1.348" "1.481" "0.961" "0.957" "1.458" "2.950" "32.8" "32.7" "41.3" "41.0" "44.1" "48.5" "31.5" "31.4" "47.8" "96.6" "" "" "" "" "" "" "" "" "" "" "29.6" "25.2" "31.9" "27.6" "36.8" "41.4" "26.7" "22.7" "32.2" "96.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585910940532122349" "False" "High" "IsMasterProtein" "Q5U5X0" "Complex III assembly factor LYRM7 OS=Homo sapiens OX=9606 GN=LYRM7 PE=1 SV=1" "0.000" "False" "11.409" "25" "2" "3" "2" "104" "11.9" "9.66" "10.70" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf05347" "90624" "ENSG00000186687" "LYRM7" "A8MPQ9; hsa:90624; Q5U5X0; Q86Y68" "" "Mitochondrial complex III assembly" "1" "0" "0.988" "0.856" "0.891" "0.887" "0.931" "0.984" "1.074" "0.843" "0.661" "172.4" "170.3" "147.6" "153.5" "153.0" "160.5" "169.6" "185.2" "145.2" "114.0" "" "" "" "" "" "" "" "" "" "" "155.6" "131.3" "114.2" "103.4" "127.6" "137.0" "143.9" "134.0" "98.0" "114.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2760060553440129895" "False" "High" "IsMasterProtein" "Q8NDB2" "B-cell scaffold protein with ankyrin repeats OS=Homo sapiens OX=9606 GN=BANK1 PE=1 SV=3" "0.000" "False" "11.394" "4" "3" "3" "3" "785" "89.2" "5.40" "10.92" "3" "signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "55024" "ENSG00000153064" "BANK1" "A8K7W8; B0F3S2; hsa:55024; Q8N5K8; Q8NB56; Q8NDB2; Q8WYN5; Q9NWP2" "" "" "0" "0" "1.051" "0.988" "1.004" "1.039" "1.057" "0.998" "0.913" "0.997" "1.756" "276.2" "290.4" "273.0" "277.4" "287.0" "292.0" "275.7" "252.3" "275.3" "485.0" "" "" "" "" "" "" "" "" "" "" "249.4" "224.0" "211.2" "186.8" "239.4" "249.2" "233.9" "182.6" "185.7" "485.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4539117867176903484" "False" "High" "IsMasterProtein" "P50402" "Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1" "0.000" "False" "11.369" "13" "3" "4" "3" "254" "29.0" "5.50" "13.33" "3" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf03020" "2010" "ENSG00000102119" "EMD" "hsa:2010; P50402; Q6FI02" "Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling" "12" "0" "0.970" "0.971" "0.926" "1.058" "0.997" "0.935" "0.995" "1.039" "1.234" "274.6" "266.3" "266.6" "254.3" "290.4" "273.7" "256.7" "273.3" "285.3" "338.8" "" "" "" "" "" "" "" "" "" "" "247.9" "205.4" "206.2" "171.2" "242.2" "233.6" "217.8" "197.8" "192.4" "338.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174373993236338878" "False" "High" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "0.000" "False" "11.351" "8" "4" "5" "3" "471" "54.2" "8.95" "14.22" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "" "mRNA processing" "1" "0" "1.131" "1.544" "1.121" "1.020" "1.384" "1.028" "0.965" "1.567" "3.371" "142.4" "161.0" "219.8" "159.5" "145.2" "197.0" "146.3" "137.3" "223.0" "479.9" "" "" "" "" "" "" "" "" "" "" "128.5" "124.2" "170.0" "107.4" "121.2" "168.1" "124.1" "99.4" "150.4" "479.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5797798922783167285" "False" "High" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "0.000" "False" "11.350" "5" "2" "2" "2" "513" "57.5" "7.18" "6.79" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-979600656900959777" "False" "High" "IsMasterProtein" "Q9HD40" "O-phosphoseryl-tRNA(Sec) selenium transferase OS=Homo sapiens OX=9606 GN=SEPSECS PE=1 SV=2" "0.000" "False" "11.346" "8" "4" "4" "4" "501" "55.7" "8.05" "10.48" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05889" "51091" "ENSG00000109618" "SEPSECS" "A8K8W1; hsa:51091; Q0D2P3; Q17RT1; Q9HD40; Q9NXZ5; Q9UGM9; Q9Y353" "Selenocysteine synthesis" "Selenium metabolism and selenoproteins" "2" "0" "0.974" "0.969" "0.989" "1.058" "0.990" "1.017" "1.051" "1.019" "0.502" "74.8" "72.9" "72.5" "74.0" "79.1" "74.1" "76.0" "78.7" "76.2" "37.5" "" "" "" "" "" "" "" "" "" "" "67.5" "56.2" "56.1" "49.8" "66.0" "63.2" "64.5" "56.9" "51.4" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023835603968378243" "False" "High" "IsMasterProtein" "O75506" "Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1" "0.000" "False" "11.329" "39" "2" "4" "2" "76" "8.5" "4.36" "8.46" "2" "stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06825" "3281" "ENSG00000230989" "HSBP1" "hsa:3281; O75506; Q53XA8; Q7Z5Z3" "HSF1 activation; Attenuation phase" "" "3" "0" "1.111" "0.886" "1.131" "1.055" "0.947" "0.991" "0.959" "0.861" "0.805" "194.8" "216.3" "172.5" "220.3" "205.5" "184.5" "193.0" "186.7" "167.8" "156.8" "" "" "" "" "" "" "" "" "" "" "175.8" "166.9" "133.5" "148.3" "171.4" "157.5" "163.7" "135.1" "113.2" "156.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3178523695898665962" "False" "High" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "0.000" "False" "11.325" "4" "4" "4" "3" "920" "106.1" "9.98" "12.10" "4" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "" "Interactome of polycomb repressive complex 2 (PRC2)" "1" "0" "1.109" "1.829" "1.163" "1.175" "1.712" "1.158" "0.943" "1.816" "1.207" "208.9" "231.6" "382.2" "243.0" "245.6" "357.7" "241.9" "196.9" "379.3" "252.1" "" "" "" "" "" "" "" "" "" "" "188.6" "178.7" "295.6" "163.6" "204.8" "305.3" "205.2" "142.5" "255.8" "252.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4118942694403519746" "False" "High" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "0.000" "False" "11.321" "4" "3" "4" "3" "652" "70.7" "7.90" "12.59" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis; RND3 GTPase cycle" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2583602978446666213" "False" "High" "IsMasterProtein" "O15514" "DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1" "0.000" "False" "11.279" "17" "2" "3" "2" "142" "16.3" "4.79" "9.38" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf03874" "5433" "ENSG00000144231" "POLR2D" "hsa:5433; O15514; Q52LT4" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism" "42" "0" "0.852" "0.982" "1.049" "0.864" "0.927" "1.005" "0.936" "0.998" "0.677" "119.3" "101.6" "117.1" "125.1" "103.0" "110.6" "119.8" "111.6" "119.0" "80.8" "" "" "" "" "" "" "" "" "" "" "107.7" "78.4" "90.6" "84.2" "86.0" "94.4" "101.6" "80.8" "80.3" "80.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752521321789384052" "False" "High" "IsMasterProtein" "P00918" "Carbonic anhydrase 2 OS=Homo sapiens OX=9606 GN=CA2 PE=1 SV=2" "0.000" "False" "11.275" "12" "3" "3" "3" "260" "29.2" "7.40" "9.20" "3" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00194" "760" "ENSG00000104267" "CA2" "B2R7G8; hsa:760; P00918; Q6FI12; Q96ET9" "Reversible hydration of carbon dioxide; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide" "Proximal tubule transport" "4" "0" "1.028" "1.212" "0.995" "1.035" "1.217" "0.753" "1.086" "1.169" "1.211" "34.9" "35.9" "42.3" "34.7" "36.1" "42.5" "26.3" "37.9" "40.8" "42.3" "" "" "" "" "" "" "" "" "" "" "31.5" "27.7" "32.7" "23.4" "30.1" "36.3" "22.3" "27.4" "27.5" "42.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5768546020460865093" "False" "High" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "0.000" "False" "11.257" "11" "3" "6" "3" "346" "39.2" "5.50" "14.41" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "15" "0" "1.001" "1.204" "1.134" "1.244" "1.233" "1.151" "0.885" "1.279" "2.390" "92.1" "92.2" "110.9" "104.4" "114.6" "113.6" "106.0" "81.5" "117.8" "220.1" "" "" "" "" "" "" "" "" "" "" "83.2" "71.1" "85.8" "70.3" "95.6" "97.0" "89.9" "59.0" "79.5" "220.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302134313779443403" "False" "High" "IsMasterProtein" "Q96ER3" "Protein SAAL1 OS=Homo sapiens OX=9606 GN=SAAL1 PE=1 SV=2" "0.000" "False" "11.245" "8" "4" "4" "4" "474" "53.5" "4.50" "13.14" "4" "other biological processes" "nucleus" "" "" "113174" "ENSG00000166788" "SAAL1" "A6NH05; hsa:113174; Q96ER3" "" "" "0" "0" "1.035" "1.031" "1.008" "1.115" "1.055" "0.915" "0.994" "1.038" "1.496" "116.8" "120.9" "120.4" "117.7" "130.3" "123.2" "106.9" "116.1" "121.3" "174.7" "" "" "" "" "" "" "" "" "" "" "105.4" "93.3" "93.1" "79.3" "108.7" "105.1" "90.7" "84.0" "81.8" "174.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7391762605629829309" "False" "High" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "0.000" "False" "11.234" "11" "4" "4" "4" "387" "44.7" "5.60" "10.71" "4" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "1.017" "0.875" "1.156" "0.951" "0.852" "1.109" "0.916" "0.836" "2.097" "181.3" "184.4" "158.6" "209.6" "172.3" "154.5" "201.0" "166.1" "151.5" "380.3" "" "" "" "" "" "" "" "" "" "" "163.7" "142.2" "122.7" "141.1" "143.8" "131.8" "170.5" "120.2" "102.2" "380.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901873737565675382" "False" "High" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "0.000" "False" "11.212" "11" "4" "4" "4" "349" "38.7" "5.78" "10.57" "4" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "1.281" "0.797" "1.016" "1.190" "1.278" "1.148" "1.129" "1.070" "0.604" "21.0" "26.9" "16.7" "21.3" "25.0" "26.8" "24.1" "23.7" "22.5" "12.7" "" "" "" "" "" "" "" "" "" "" "18.9" "20.7" "12.9" "14.4" "20.8" "22.9" "20.4" "17.1" "15.1" "12.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8960608706317852180" "False" "High" "IsMasterProtein" "A1L188" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 OS=Homo sapiens OX=9606 GN=NDUFAF8 PE=1 SV=1" "0.000" "False" "11.208" "32" "2" "2" "2" "74" "7.8" "9.32" "7.27" "2" "cell organization and biogenesis" "mitochondrion" "" "" "284184" "ENSG00000224877" "NDUFAF8" "A1L188; hsa:284184" "" "" "0" "0" "0.974" "1.031" "0.968" "1.100" "1.130" "1.019" "0.913" "1.138" "0.668" "136.0" "132.4" "140.1" "131.7" "149.6" "153.7" "138.5" "124.2" "154.7" "90.9" "" "" "" "" "" "" "" "" "" "" "122.7" "102.2" "108.4" "88.7" "124.8" "131.2" "117.5" "89.9" "104.4" "90.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8214160649428381093" "False" "High" "IsMasterProtein" "P22415" "Upstream stimulatory factor 1 OS=Homo sapiens OX=9606 GN=USF1 PE=1 SV=1" "0.000" "False" "11.187" "11" "3" "3" "3" "310" "33.5" "5.54" "9.53" "3" "stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7391" "ENSG00000158773" "USF1" "B2RBZ4; hsa:7391; P22415; Q5SY46; Q7Z5Y1" "Estrogen-dependent gene expression" "7q11.23 copy number variation syndrome; Familial hyperlipidemia type 2" "3" "0" "1.245" "0.911" "1.595" "1.117" "1.117" "1.214" "1.371" "0.903" "1.522" "53.5" "66.5" "48.7" "85.3" "59.7" "59.7" "64.9" "73.3" "48.3" "81.4" "" "" "" "" "" "" "" "" "" "" "48.3" "51.3" "37.7" "57.4" "49.8" "51.0" "55.1" "53.0" "32.6" "81.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7495090606117370342" "False" "High" "IsMasterProtein" "P08631" "Tyrosine-protein kinase HCK OS=Homo sapiens OX=9606 GN=HCK PE=1 SV=5" "0.000" "False" "11.187" "6" "4" "7" "2" "526" "59.6" "6.70" "15.48" "4" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "3055" "ENSG00000101336" "HCK" "A8K1I1; B4DQB6; E1P5M2; hsa:3055; P08631; Q29RX1; Q2VPE2; Q504R5; Q5T7K1; Q5T7K2; Q96CC0; Q9H5Y5; Q9NUA4; Q9UMJ5" "FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Nef and signal transduction; FLT3 signaling through SRC family kinases" "Thymic stromal lymphopoietin (TSLP) signaling pathway; IL-3 signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway" "15" "0" "0.999" "0.857" "1.069" "1.115" "0.733" "1.199" "1.047" "0.758" "1.474" "120.5" "120.4" "103.2" "128.7" "134.3" "88.3" "144.4" "126.1" "91.3" "177.6" "" "" "" "" "" "" "" "" "" "" "108.7" "92.9" "79.8" "86.7" "112.0" "75.4" "122.5" "91.2" "61.6" "177.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4153058016593714536" "False" "High" "IsMasterProtein" "Q9UKT5" "F-box only protein 4 OS=Homo sapiens OX=9606 GN=FBXO4 PE=1 SV=2" "0.000" "False" "11.179" "5" "2" "2" "2" "387" "44.1" "6.16" "6.62" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646" "26272" "ENSG00000151876" "FBXO4" "hsa:26272; Q68CU8; Q86VT8; Q9UK98; Q9UKT5" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "1.043" "0.843" "1.027" "0.943" "0.773" "1.039" "0.901" "0.863" "0.800" "132.8" "138.5" "111.9" "136.4" "125.3" "102.7" "138.0" "119.6" "114.6" "106.2" "" "" "" "" "" "" "" "" "" "" "119.9" "106.9" "86.5" "91.8" "104.5" "87.6" "117.0" "86.5" "77.3" "106.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2163956888383823018" "False" "High" "IsMasterProtein" "Q96A65" "Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1" "0.000" "False" "11.177" "2" "2" "2" "2" "974" "110.4" "6.49" "7.03" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04048, Pf20652" "60412" "ENSG00000131558" "EXOC4" "E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "0.998" "0.810" "1.204" "0.860" "0.825" "1.112" "0.631" "0.853" "5.031" "62.3" "62.2" "50.5" "75.0" "53.6" "51.4" "69.3" "39.3" "53.1" "313.4" "" "" "" "" "" "" "" "" "" "" "56.2" "47.9" "39.0" "50.5" "44.7" "43.9" "58.8" "28.5" "35.8" "313.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657288411045177937" "False" "High" "IsMasterProtein" "O95429" "BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1" "0.000" "False" "11.170" "8" "3" "3" "2" "457" "49.6" "5.12" "7.33" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02179" "9530" "ENSG00000156735" "BAG4" "B4E217; hsa:9530; O95429; O95818" "Regulation of HSF1-mediated heat shock response; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions; TNF signaling" "Oxidative damage response" "5" "0" "1.098" "1.081" "1.128" "1.016" "1.269" "0.974" "0.905" "1.053" "0.968" "75.3" "82.7" "81.4" "85.0" "76.5" "95.6" "73.4" "68.2" "79.3" "72.9" "" "" "" "" "" "" "" "" "" "" "68.0" "63.8" "63.0" "57.2" "63.8" "81.6" "62.3" "49.3" "53.5" "72.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8767729618822811067" "False" "High" "IsMasterProtein" "O14933" "Ubiquitin/ISG15-conjugating enzyme E2 L6 OS=Homo sapiens OX=9606 GN=UBE2L6 PE=1 SV=4" "0.000" "False" "11.133" "15" "2" "3" "2" "153" "17.8" "7.88" "12.24" "2" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "9246" "ENSG00000156587" "UBE2L6" "A6NDM6; A8MY53; hsa:9246; O14933; Q8N5D8; Q9UEZ0" "Antigen processing: Ubiquitination & Proteasome degradation; RSV-host interactions; Amyloid fiber formation; PKR-mediated signaling; ISG15 antiviral mechanism; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; 7q11.23 copy number variation syndrome" "11" "0" "1.192" "0.981" "1.103" "1.102" "0.980" "1.089" "1.015" "0.945" "1.713" "139.8" "166.6" "137.2" "154.1" "154.0" "136.9" "152.2" "141.9" "132.1" "239.5" "" "" "" "" "" "" "" "" "" "" "126.2" "128.5" "106.1" "103.8" "128.5" "116.9" "129.1" "102.7" "89.1" "239.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004188409903141881" "False" "High" "IsMasterProtein" "P52758" "2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1" "0.000" "False" "11.122" "20" "2" "3" "2" "137" "14.5" "8.68" "10.52" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01042" "10247" "ENSG00000132541" "RIDA" "hsa:10247; P52758; Q6FHU9; Q6IBG0" "Threonine catabolism" "" "1" "0" "0.839" "0.750" "0.803" "0.925" "0.932" "0.729" "0.728" "0.862" "0.622" "63.0" "52.9" "47.3" "50.6" "58.2" "58.7" "45.9" "45.9" "54.3" "39.2" "" "" "" "" "" "" "" "" "" "" "56.9" "40.8" "36.5" "34.1" "48.6" "50.1" "38.9" "33.2" "36.6" "39.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703372283530206058" "False" "High" "IsMasterProtein" "Q9NP97" "Dynein light chain roadblock-type 1 OS=Homo sapiens OX=9606 GN=DYNLRB1 PE=1 SV=3" "0.000" "False" "11.101" "22" "2" "7" "2" "96" "10.9" "7.25" "17.53" "2" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83658" "ENSG00000125971" "DYNLRB1" "B1AKR5; hsa:83658; Q5TC72; Q96IV3; Q9NP97; Q9NQM2" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "4" "0" "0.997" "0.913" "1.085" "0.959" "0.959" "1.029" "0.963" "0.873" "1.080" "177.9" "177.4" "162.5" "193.1" "170.6" "170.6" "183.0" "171.4" "155.4" "192.2" "" "" "" "" "" "" "" "" "" "" "160.6" "136.8" "125.6" "130.0" "142.3" "145.6" "155.3" "124.1" "104.8" "192.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965244756027354747" "False" "High" "IsMasterProtein" "O75414" "Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3" "0.000" "False" "11.098" "13" "2" "2" "2" "186" "21.1" "8.32" "7.17" "2" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf00334" "10201" "ENSG00000172113" "NME6" "B4DGW7; B4DM99; hsa:10201; O75414; Q53HM5; Q96E73; Q9BQ63" "" "Pyrimidine metabolism" "1" "0" "1.097" "1.218" "1.121" "1.129" "1.108" "1.076" "1.031" "1.183" "0.760" "51.3" "56.2" "62.4" "57.4" "57.9" "56.8" "55.1" "52.8" "60.6" "39.0" "" "" "" "" "" "" "" "" "" "" "46.3" "43.4" "48.3" "38.7" "48.3" "48.5" "46.8" "38.2" "40.9" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7388585802174213380" "False" "High" "IsMasterProtein" "Q06187" "Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3" "0.000" "False" "11.085" "8" "6" "7" "6" "659" "76.2" "7.77" "16.24" "6" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf00169, Pf00779, Pf07714" "695" "ENSG00000010671" "BTK" "B2RAW1; hsa:695; Q06187; Q32ML5" "FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; ER-Phagosome pathway; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated Ca+2 mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; G alpha (12/13) signalling events; G alpha (q) signalling events; RHO GTPases Activate WASPs and WAVEs; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); DAP12 signaling; G beta:gamma signalling through BTK" "IL-5 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "20" "0" "0.936" "1.059" "1.256" "0.983" "1.029" "1.207" "0.791" "1.202" "6.556" "51.1" "47.9" "54.1" "64.2" "50.3" "52.6" "61.7" "40.4" "61.4" "335.2" "" "" "" "" "" "" "" "" "" "" "46.2" "36.9" "41.9" "43.2" "41.9" "44.9" "52.3" "29.3" "41.4" "335.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8714366505281620526" "False" "High" "IsMasterProtein" "Q7L5Y9" "E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1" "0.000" "False" "11.083" "9" "4" "4" "4" "396" "45.3" "8.69" "11.52" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10607" "10296" "ENSG00000090316" "MAEA" "hsa:10296; O95285; Q5JB54; Q6ZRD6; Q7L5Y9; Q9BQ11; Q9H9V6; Q9H9Z4; Q9NW84" "" "Ciliary landscape" "1" "0" "0.901" "0.740" "0.995" "0.932" "0.768" "0.964" "0.977" "0.801" "1.185" "265.8" "239.5" "196.7" "264.5" "247.8" "204.1" "256.2" "259.7" "213.0" "314.9" "" "" "" "" "" "" "" "" "" "" "239.9" "184.7" "152.1" "178.1" "206.7" "174.2" "217.4" "187.9" "143.7" "314.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1107540500627023376" "False" "High" "IsMasterProtein" "Q96EE3" "Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3" "0.000" "False" "11.081" "10" "4" "5" "4" "360" "39.6" "8.09" "12.36" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "81929" "ENSG00000085415" "SEH1L" "A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069" "Amino acids regulate mTORC1" "" "1" "0" "0.952" "0.878" "1.027" "1.076" "0.808" "0.954" "1.074" "0.968" "0.876" "128.8" "122.6" "113.0" "132.3" "138.6" "104.0" "122.8" "138.3" "124.6" "112.8" "" "" "" "" "" "" "" "" "" "" "116.2" "94.6" "87.4" "89.1" "115.6" "88.8" "104.2" "100.1" "84.0" "112.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1131809670189224217" "False" "High" "IsMasterProtein" "Q96EY7" "Small ribosomal subunit protein mS39 OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" "0.000" "False" "11.076" "4" "2" "2" "2" "689" "78.5" "6.42" "6.66" "2" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "translation activity;nucleic acid binding activity" "Pf13041, Pf13812" "55037" "ENSG00000132300" "PTCD3" "A6NHD2; D6W5M1; hsa:55037; Q597H0; Q658Y9; Q96EY7; Q9BUZ8; Q9NWL0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.850" "0.767" "0.815" "0.919" "0.764" "0.834" "0.780" "0.717" "1.595" "158.4" "134.6" "121.5" "129.1" "145.5" "121.0" "132.1" "123.5" "113.5" "252.6" "" "" "" "" "" "" "" "" "" "" "143.0" "103.8" "94.0" "87.0" "121.4" "103.3" "112.0" "89.4" "76.5" "252.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7748730165992048021" "False" "High" "IsMasterProtein" "Q6UWE0" "E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens OX=9606 GN=LRSAM1 PE=1 SV=1" "0.000" "False" "11.059" "4" "3" "3" "3" "723" "83.5" "5.94" "8.44" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf07647, Pf13855, Pf13920" "90678" "ENSG00000148356" "LRSAM1" "Q5VVV0; Q6UWE0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7" "Antigen processing: Ubiquitination & Proteasome degradation" "Intracellular trafficking proteins involved in CMT neuropathy" "2" "0" "1.038" "0.783" "1.114" "0.981" "0.658" "1.067" "0.931" "0.800" "1.272" "149.8" "155.5" "117.3" "166.8" "147.0" "98.6" "159.8" "139.4" "119.8" "190.5" "" "" "" "" "" "" "" "" "" "" "135.2" "120.0" "90.7" "112.3" "122.6" "84.1" "135.6" "100.9" "80.8" "190.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3718906404474103384" "False" "High" "IsMasterProtein" "P19174" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1" "0.000" "False" "11.057" "3" "5" "5" "5" "1290" "148.4" "6.05" "13.32" "5" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388" "5335" "ENSG00000124181" "PLCG1" "B7ZLY7; B9EGH4; E1P5W4; hsa:5335; P19174; Q2V575" "ISG15 antiviral mechanism; Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Signaling by ALK fusions and activated point mutants; RET signaling; Downstream signal transduction; Signaling by ALK; DAP12 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; EGFR interacts with phospholipase C-gamma; Signaling by FGFR1 in disease; Synthesis of IP3 and IP4 in the cytosol; Phospholipase C-mediated cascade: FGFR1; Phospholipase C-mediated cascade; FGFR2; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Phospholipase C-mediated cascade; FGFR3; Phospholipase C-mediated cascade; FGFR4; Signaling by FGFR3 in disease; DAG and IP3 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Role of second messengers in netrin-1 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; PLC-gamma1 signalling; PECAM1 interactions; Activated NTRK2 signals through PLCG1; Activated NTRK3 signals through PLCG1" "Angiogenesis; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; PDGF pathway; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; GPR40 pathway; PDGFR-beta pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-small cell lung cancer; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway; T-cell receptor signaling pathway" "76" "0" "1.029" "0.786" "1.068" "0.941" "0.789" "0.938" "0.624" "0.748" "3.031" "111.3" "114.5" "87.4" "118.9" "104.7" "87.8" "104.3" "69.4" "83.3" "337.3" "" "" "" "" "" "" "" "" "" "" "100.4" "88.3" "67.6" "80.0" "87.3" "74.9" "88.5" "50.3" "56.2" "337.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5375440904508103637" "False" "High" "IsMasterProtein" "Q6ZSJ8" "Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=1 SV=2" "0.000" "False" "11.051" "17" "2" "4" "2" "110" "11.5" "6.73" "9.42" "2" "" "" "" "Pf15855" "127687" "ENSG00000197982" "C1orf122" "A2RQF4; E9PQ13; hsa:127687; Q56A71; Q6ZSJ8" "" "" "0" "0" "1.020" "0.896" "0.988" "0.855" "0.947" "0.928" "0.990" "1.078" "0.905" "82.1" "83.8" "73.6" "81.2" "70.3" "77.8" "76.2" "81.3" "88.6" "74.4" "" "" "" "" "" "" "" "" "" "" "74.1" "64.6" "56.9" "54.6" "58.6" "66.4" "64.7" "58.9" "59.7" "74.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285905538601848760" "False" "High" "IsMasterProtein" "Q9H0E9" "Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2" "0.000" "False" "10.979" "2" "3" "3" "3" "1235" "135.3" "4.60" "9.70" "3" "cell organization and biogenesis;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00439" "10902" "ENSG00000112983" "BRD8" "hsa:10902; O43178; Q15355; Q58AB0; Q59GN0; Q969M9; Q9H0E9" "HATs acetylate histones" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65550439794871329" "False" "High" "IsMasterProtein" "Q9BXS5" "AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3" "0.000" "False" "10.965" "8" "4" "6" "4" "423" "48.6" "7.30" "18.88" "4" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "8907" "ENSG00000072958" "AP1M1" "hsa:8907; Q4TTY5; Q9BXS5" "Neutrophil degranulation; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "5" "0" "0.879" "1.271" "1.051" "1.105" "1.189" "1.160" "0.970" "1.159" "1.782" "163.5" "143.7" "207.9" "171.9" "180.7" "194.4" "189.8" "158.6" "189.5" "291.4" "" "" "" "" "" "" "" "" "" "" "147.6" "110.9" "160.8" "115.7" "150.7" "165.9" "161.0" "114.8" "127.8" "291.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3771039295331557619" "False" "High" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "0.000" "False" "10.940" "4" "2" "4" "2" "445" "50.4" "8.27" "12.73" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "Lipid metabolism pathway" "3" "0" "1.010" "0.705" "0.908" "0.875" "0.914" "0.856" "0.914" "0.796" "0.657" "89.3" "90.2" "63.0" "81.1" "78.2" "81.7" "76.5" "81.6" "71.1" "58.7" "" "" "" "" "" "" "" "" "" "" "80.7" "69.6" "48.7" "54.6" "65.2" "69.7" "64.9" "59.1" "48.0" "58.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7090269578477503572" "False" "High" "IsMasterProtein" "P29353" "SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4" "0.000" "False" "10.938" "5" "2" "2" "2" "583" "62.8" "6.44" "7.53" "2" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00640" "6464" "ENSG00000160691" "SHC1" "B5BU19; D3DV78; hsa:6464; O15290; P29353; Q5T180; Q5T183; Q5T184; Q5T185; Q5T186; Q8N4K5; Q96CL1" "Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "65" "0" "1.072" "0.874" "1.148" "0.921" "0.936" "1.028" "1.069" "0.916" "0.794" "149.0" "159.8" "130.2" "171.0" "137.3" "139.4" "153.1" "159.3" "136.5" "118.3" "" "" "" "" "" "" "" "" "" "" "134.5" "123.2" "100.7" "115.1" "114.5" "119.0" "129.9" "115.3" "92.1" "118.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8527831482180649662" "False" "High" "IsMasterProtein" "Q8NCE2" "Myotubularin-related protein 14 OS=Homo sapiens OX=9606 GN=MTMR14 PE=1 SV=2" "0.000" "False" "10.936" "4" "2" "2" "2" "650" "72.2" "6.24" "6.99" "2" "other metabolic processes" "cytosol;other cell component" "other molecular function" "" "64419" "ENSG00000163719" "MTMR14" "hsa:64419; Q0JTH5; Q0JU83; Q6PIZ4; Q6QE21; Q86VK9; Q8IYK1; Q8NCE2; Q8TCM7; Q9H6C0" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "" "2" "0" "1.057" "0.835" "1.123" "1.116" "0.997" "0.993" "1.054" "1.017" "1.197" "95.5" "100.9" "79.7" "107.2" "106.6" "95.2" "94.8" "100.6" "97.1" "114.3" "" "" "" "" "" "" "" "" "" "" "86.2" "77.8" "61.7" "72.2" "88.9" "81.3" "80.5" "72.8" "65.5" "114.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2863197479310684416" "False" "High" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "0.000" "False" "10.932" "6" "1" "5" "1" "184" "20.7" "7.99" "15.09" "1" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "1.028" "0.956" "1.140" "0.969" "1.076" "0.935" "0.980" "1.068" "0.647" "327.4" "336.6" "312.9" "373.2" "317.3" "352.3" "306.3" "320.7" "349.5" "211.8" "" "" "" "" "" "" "" "" "" "" "295.5" "259.6" "242.0" "251.3" "264.7" "300.7" "259.8" "232.1" "235.8" "211.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8009088926221679389" "False" "High" "IsMasterProtein" "P40616" "ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1" "0.000" "False" "10.930" "13" "2" "4" "2" "181" "20.4" "5.72" "10.53" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00025" "400" "ENSG00000120805" "ARL1" "B4DWW1; hsa:400; P40616; P80417; Q53XB1" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.150" "0.931" "1.607" "1.228" "0.806" "1.240" "1.154" "0.639" "0.760" "24.9" "28.6" "23.2" "40.0" "30.6" "20.1" "30.8" "28.7" "15.9" "18.9" "" "" "" "" "" "" "" "" "" "" "22.5" "22.1" "17.9" "26.9" "25.5" "17.1" "26.2" "20.8" "10.7" "18.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9128432651374987381" "False" "High" "IsMasterProtein" "Q9NNW5" "tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1" "0.000" "False" "10.922" "2" "3" "3" "3" "1121" "121.6" "6.87" "9.34" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00400" "11180" "ENSG00000178252" "WDR6" "B4DHK2; hsa:11180; Q3MIT1; Q9NNW5; Q9UF63" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "" "5" "0" "0.973" "0.897" "0.915" "0.934" "0.815" "0.886" "0.967" "0.810" "0.943" "90.9" "88.4" "81.5" "83.1" "84.9" "74.1" "80.5" "87.8" "73.6" "85.7" "" "" "" "" "" "" "" "" "" "" "82.0" "68.2" "63.0" "56.0" "70.8" "63.2" "68.3" "63.6" "49.7" "85.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385362476021457625" "False" "High" "IsMasterProtein" "B3KNS4" "Endogenous retrovirus group K3 member 1 OS=Homo sapiens OX=9606 GN=ERVK3-1 PE=1 SV=1" "0.000" "False" "10.918" "19" "2" "4" "2" "109" "11.6" "7.78" "12.45" "2" "" "" "" "Pf15695" "" "ENSG00000142396" "ERVK3-1" "B3KNS4" "" "" "0" "0" "1.184" "1.270" "1.249" "1.129" "1.160" "1.106" "1.470" "1.163" "0.907" "227.8" "269.6" "289.3" "284.4" "257.1" "264.3" "252.0" "334.7" "264.8" "206.5" "" "" "" "" "" "" "" "" "" "" "205.6" "208.0" "223.8" "191.5" "214.4" "225.6" "213.8" "242.2" "178.6" "206.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7148094604996287167" "False" "High" "IsMasterProtein" "Q9Y3E1" "Hepatoma-derived growth factor-related protein 3 OS=Homo sapiens OX=9606 GN=HDGFL3 PE=1 SV=1" "0.000" "False" "10.891" "16" "3" "5" "2" "203" "22.6" "7.99" "14.63" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00855" "50810" "ENSG00000166503" "HDGFL3" "hsa:50810; Q9Y3E1" "" "" "0" "0" "1.121" "1.165" "1.122" "1.002" "0.919" "0.889" "1.246" "1.110" "0.751" "166.5" "186.7" "193.9" "186.9" "166.9" "153.0" "148.0" "207.5" "184.9" "125.0" "" "" "" "" "" "" "" "" "" "" "150.3" "144.0" "150.0" "125.8" "139.2" "130.6" "125.5" "150.2" "124.7" "125.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263774820605261131" "False" "High" "IsMasterProtein" "Q9BTK6" "PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=PAGR1 PE=1 SV=1" "0.000" "False" "10.881" "11" "2" "2" "2" "254" "27.7" "4.46" "7.01" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf15364" "79447" "ENSG00000280789" "PAGR1" "A2ICR6; hsa:79447; Q9BTK6" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis" "16p11.2 proximal deletion syndrome; Kleefstra syndrome" "4" "0" "0.842" "0.858" "1.416" "1.351" "0.765" "1.158" "0.896" "1.004" "0.973" "13.8" "11.6" "11.9" "19.6" "18.7" "10.6" "16.0" "12.4" "13.9" "13.5" "" "" "" "" "" "" "" "" "" "" "12.5" "9.0" "9.2" "13.2" "15.6" "9.0" "13.6" "9.0" "9.4" "13.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6739542972395274555" "False" "High" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "0.000" "False" "10.868" "2" "4" "4" "4" "1576" "171.4" "8.09" "12.20" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "0" "1.068" "0.989" "1.216" "1.034" "0.956" "1.022" "1.071" "1.032" "0.910" "197.9" "211.3" "195.7" "240.6" "204.7" "189.2" "202.2" "211.9" "204.3" "180.2" "" "" "" "" "" "" "" "" "" "" "178.7" "163.0" "151.4" "162.0" "170.7" "161.5" "171.5" "153.4" "137.8" "180.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870443060398404245" "False" "High" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "0.000" "False" "10.859" "19" "3" "3" "2" "130" "14.4" "9.11" "9.75" "3" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "1" "0.986" "1.152" "0.993" "1.006" "0.928" "1.001" "1.046" "1.021" "0.681" "296.2" "292.0" "341.2" "294.1" "298.0" "275.0" "296.4" "309.8" "302.4" "201.7" "" "" "" "" "" "" "" "" "" "" "267.4" "225.3" "263.9" "198.0" "248.6" "234.7" "251.5" "224.2" "204.0" "201.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7172726289989085897" "False" "High" "IsMasterProtein" "Q8IYB5" "Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2" "0.000" "False" "10.851" "4" "2" "2" "2" "467" "50.4" "8.75" "8.31" "2" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "60682" "ENSG00000112305" "SMAP1" "hsa:60682; Q53H70; Q5SYQ2; Q6PK24; Q8IYB5; Q8NDH4; Q96L38; Q96L39; Q9H8X4" "" "" "0" "0" "0.979" "1.099" "0.928" "0.939" "1.059" "0.966" "1.068" "1.170" "0.893" "207.6" "203.1" "228.0" "192.5" "194.9" "219.8" "200.5" "221.6" "242.8" "185.4" "" "" "" "" "" "" "" "" "" "" "187.4" "156.7" "176.3" "129.6" "162.6" "187.6" "170.1" "160.4" "163.7" "185.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119048535094086908" "False" "High" "IsMasterProtein" "P82912" "Small ribosomal subunit protein uS11m OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" "0.000" "False" "10.832" "8" "1" "1" "1" "194" "20.6" "10.81" "4.27" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00411" "64963" "ENSG00000181991" "MRPS11" "B2RD52; hsa:64963; P82912; Q969D7; Q96GI3; Q9BYC3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5954226143684266914" "False" "High" "IsMasterProtein" "P10398" "Serine/threonine-protein kinase A-Raf OS=Homo sapiens OX=9606 GN=ARAF PE=1 SV=2" "0.000" "False" "10.820" "7" "4" "4" "2" "606" "67.5" "9.01" "11.80" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "369" "ENSG00000078061" "ARAF" "hsa:369; P07557; P10398; Q5H9B2; Q5H9B3" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Common pathways underlying drug addiction; Bladder cancer; MAPK signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway" "33" "0" "0.766" "0.968" "1.031" "0.813" "0.939" "0.804" "0.974" "0.992" "1.494" "28.2" "21.6" "27.3" "29.1" "23.0" "26.5" "22.7" "27.5" "28.0" "42.2" "" "" "" "" "" "" "" "" "" "" "25.5" "16.7" "21.1" "19.6" "19.1" "22.6" "19.3" "19.9" "18.9" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-958825745261361591" "False" "High" "IsMasterProtein" "Q7Z3J2" "VPS35 endosomal protein-sorting factor-like OS=Homo sapiens OX=9606 GN=VPS35L PE=1 SV=2" "0.000" "False" "10.806" "3" "3" "4" "3" "963" "109.5" "7.21" "9.52" "3" "transport" "plasma membrane;other membranes;other cytoplasmic organelle" "" "" "57020" "ENSG00000103544" "VPS35L" "A8K2M1; hsa:57020; O43329; Q69YI1; Q6PDA0; Q7L371; Q7Z3J2; Q86W66; Q8WXA5; Q9H0L7; Q9H7C8" "Neutrophil degranulation" "" "1" "0" "1.206" "0.794" "1.044" "1.052" "1.131" "1.230" "1.020" "1.244" "1.330" "71.1" "85.7" "56.4" "74.2" "74.8" "80.4" "87.4" "72.5" "88.4" "94.5" "" "" "" "" "" "" "" "" "" "" "64.2" "66.1" "43.6" "50.0" "62.4" "68.6" "74.2" "52.5" "59.7" "94.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3427598645898203721" "False" "High" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "0.000" "False" "10.803" "7" "2" "3" "2" "347" "38.3" "7.64" "11.53" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "1.012" "1.003" "0.957" "1.342" "0.997" "1.254" "1.048" "0.822" "0.886" "57.6" "58.3" "57.8" "55.2" "77.3" "57.5" "72.3" "60.4" "47.4" "51.0" "" "" "" "" "" "" "" "" "" "" "52.0" "45.0" "44.7" "37.2" "64.5" "49.0" "61.3" "43.7" "31.9" "51.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573185288358324905" "False" "High" "IsMasterProtein" "P21953" "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2" "0.000" "False" "10.791" "8" "3" "3" "3" "392" "43.1" "6.29" "8.18" "3" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02779, Pf02780" "594" "ENSG00000083123" "BCKDHB" "hsa:594; P21953; Q5T2J3; Q9BQL0" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "Primary ovarian insufficiency" "3" "0" "1.063" "0.870" "1.288" "1.099" "0.967" "1.061" "1.204" "0.958" "0.615" "60.5" "64.4" "52.7" "77.9" "66.5" "58.5" "64.2" "72.8" "58.0" "37.2" "" "" "" "" "" "" "" "" "" "" "54.6" "49.6" "40.7" "52.5" "55.5" "49.9" "54.5" "52.7" "39.1" "37.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558659697255910600" "False" "High" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=1 SV=2" "0.000" "False" "10.784" "6" "3" "4" "3" "370" "41.5" "8.18" "15.26" "3" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "Pathogenic Escherichia coli infection" "6" "0" "0.997" "1.041" "1.050" "1.108" "1.244" "1.127" "1.068" "1.135" "0.852" "142.9" "142.4" "148.6" "150.0" "158.3" "177.7" "160.9" "152.6" "162.1" "121.8" "" "" "" "" "" "" "" "" "" "" "129.0" "109.9" "115.0" "101.0" "132.1" "151.6" "136.5" "110.4" "109.4" "121.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407344682093019997" "False" "High" "IsMasterProtein" "Q53GL0" "Pleckstrin homology domain-containing family O member 1 OS=Homo sapiens OX=9606 GN=PLEKHO1 PE=1 SV=2" "0.000" "False" "10.779" "10" "4" "4" "4" "409" "46.2" "8.82" "9.89" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf00169" "51177" "ENSG00000023902" "PLEKHO1" "hsa:51177; Q336K5; Q53GL0; Q8IZ51; Q9NRV3; Q9UL48" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6504309841328491303" "False" "High" "IsMasterProtein" "Q8NAF0" "Zinc finger protein 579 OS=Homo sapiens OX=9606 GN=ZNF579 PE=1 SV=2" "0.000" "False" "10.766" "4" "2" "2" "2" "562" "60.5" "8.69" "7.76" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "163033" "ENSG00000218891" "ZNF579" "hsa:163033; Q8NAF0" "" "" "0" "0" "1.011" "0.872" "1.158" "1.020" "0.789" "1.070" "1.043" "0.789" "0.881" "173.9" "175.7" "151.7" "201.3" "177.3" "137.2" "186.1" "181.4" "137.2" "153.2" "" "" "" "" "" "" "" "" "" "" "157.0" "135.6" "117.3" "135.6" "147.9" "117.1" "157.9" "131.3" "92.5" "153.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4000962258629935056" "False" "High" "IsMasterProtein" "P62847" "Small ribosomal subunit protein eS24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1" "0.000" "False" "10.758" "17" "2" "5" "2" "133" "15.4" "10.78" "14.43" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01282" "6229" "ENSG00000138326" "RPS24" "E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "0.977" "1.262" "0.814" "1.192" "1.309" "0.966" "1.063" "1.140" "0.624" "103.7" "101.3" "130.9" "84.4" "123.6" "135.7" "100.2" "110.2" "118.3" "64.7" "" "" "" "" "" "" "" "" "" "" "93.6" "78.1" "101.2" "56.8" "103.1" "115.8" "85.0" "79.8" "79.8" "64.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9134922039646345365" "False" "High" "IsMasterProtein" "Q8NBF2" "NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1" "0.000" "False" "10.733" "7" "4" "4" "4" "726" "79.4" "5.55" "11.23" "4" "" "non-structural extracellular;cytosol;other cell component" "" "Pf01436, Pf13905" "374354" "ENSG00000196865" "NHLRC2" "hsa:374354; Q8N1H1; Q8N5A6; Q8NBF2" "Platelet degranulation" "" "1" "0" "1.023" "0.636" "0.983" "0.884" "0.755" "0.876" "0.901" "0.708" "0.934" "228.1" "233.3" "145.1" "224.3" "201.7" "172.2" "199.8" "205.6" "161.5" "213.0" "" "" "" "" "" "" "" "" "" "" "205.9" "180.0" "112.3" "151.1" "168.3" "147.0" "169.5" "148.8" "108.9" "213.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686593457953999194" "False" "High" "IsMasterProtein" "P45985" "Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1" "0.000" "False" "10.731" "7" "3" "3" "3" "399" "44.3" "8.07" "9.61" "3" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6416" "ENSG00000065559" "MAP2K4" "B2R7N7; B3KYB2; D3DTS5; hsa:6416; P45985; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6" "Oxidative Stress Induced Senescence; FCERI mediated MAPK activation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; PDGF pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "35" "0" "0.997" "0.697" "1.056" "1.060" "0.717" "1.014" "0.966" "0.768" "0.796" "451.5" "450.3" "314.8" "476.8" "478.6" "323.9" "457.7" "436.2" "346.8" "359.2" "" "" "" "" "" "" "" "" "" "" "407.5" "347.4" "243.5" "321.1" "399.2" "276.4" "388.2" "315.7" "233.9" "359.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3984777124948273039" "False" "High" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "0.000" "False" "10.728" "11" "3" "3" "3" "275" "30.3" "7.50" "7.82" "3" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "O94903; Q6FI94" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4178938987355296714" "False" "High" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "0.000" "False" "10.719" "33" "3" "6" "3" "80" "9.1" "9.58" "15.90" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "" "2" "0" "0.965" "1.005" "1.010" "0.922" "1.066" "0.931" "1.140" "1.069" "0.757" "335.2" "323.5" "337.0" "338.7" "308.9" "357.3" "312.0" "382.0" "358.4" "253.7" "" "" "" "" "" "" "" "" "" "" "302.6" "249.5" "260.6" "228.1" "257.7" "305.0" "264.6" "276.4" "241.7" "253.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-708383096801431027" "False" "High" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "0.000" "False" "10.716" "12" "1" "3" "1" "91" "10.8" "10.73" "9.61" "1" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "2" "0" "1.137" "1.002" "1.039" "1.026" "1.056" "1.131" "1.107" "0.985" "0.866" "95.3" "108.4" "95.4" "99.0" "97.8" "100.6" "107.7" "105.5" "93.8" "82.5" "" "" "" "" "" "" "" "" "" "" "86.0" "83.6" "73.8" "66.7" "81.6" "85.9" "91.4" "76.3" "63.3" "82.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-379596745727063060" "False" "High" "IsMasterProtein" "Q96CW6" "Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Homo sapiens OX=9606 GN=SLC7A6OS PE=1 SV=2" "0.000" "False" "10.697" "9" "3" "3" "3" "309" "35.0" "4.60" "8.71" "3" "transport;other biological processes" "nucleus;other cell component" "" "Pf08574" "84138" "ENSG00000103061" "SLC7A6OS" "hsa:84138; Q8TCZ3; Q96CW6; Q9H8R8" "" "" "0" "0" "0.911" "0.804" "1.094" "1.054" "0.863" "1.035" "1.144" "0.892" "0.856" "236.9" "215.7" "190.4" "259.2" "249.7" "204.4" "245.1" "271.1" "211.3" "202.9" "" "" "" "" "" "" "" "" "" "" "213.8" "166.4" "147.2" "174.5" "208.3" "174.4" "208.0" "196.2" "142.5" "202.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2241526083572897290" "False" "High" "IsMasterProtein" "Q9ULX6" "A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4" "0.000" "False" "10.695" "6" "3" "3" "3" "646" "71.6" "5.05" "9.03" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "26993" "ENSG00000011243" "AKAP8L" "B4DJ74; B5BU90; hsa:26993; O94792; Q96J58; Q9NRQ0; Q9UGM0; Q9ULX6" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "0.873" "1.537" "0.958" "0.972" "1.307" "0.773" "1.064" "1.496" "4.811" "77.3" "67.5" "118.8" "74.1" "75.1" "101.1" "59.7" "82.2" "115.7" "372.0" "" "" "" "" "" "" "" "" "" "" "69.8" "52.0" "91.9" "49.9" "62.7" "86.3" "50.7" "59.5" "78.0" "372.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5940813161561783541" "False" "High" "IsMasterProtein" "Q9H078" "Mitochondrial disaggregase OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "0.000" "False" "10.670" "4" "3" "4" "3" "707" "78.7" "9.01" "10.66" "3" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "0.931" "0.706" "0.965" "1.086" "0.748" "0.996" "0.909" "0.765" "0.638" "172.3" "160.4" "121.6" "166.2" "187.1" "128.9" "171.6" "156.6" "131.8" "109.9" "" "" "" "" "" "" "" "" "" "" "155.5" "123.8" "94.1" "111.9" "156.1" "110.0" "145.6" "113.3" "88.9" "109.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5558821625919889641" "False" "High" "IsMasterProtein" "Q9UDY4" "DnaJ homolog subfamily B member 4 OS=Homo sapiens OX=9606 GN=DNAJB4 PE=1 SV=1" "0.000" "False" "10.662" "8" "2" "2" "1" "337" "37.8" "8.50" "6.67" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00226, Pf01556" "11080" "ENSG00000162616" "DNAJB4" "B2R824; hsa:11080; Q13431; Q9UDY4" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.863" "0.993" "1.044" "0.882" "1.216" "0.823" "0.840" "1.175" "1.718" "60.4" "52.2" "60.0" "63.1" "53.3" "73.5" "49.7" "50.7" "71.0" "103.8" "" "" "" "" "" "" "" "" "" "" "54.5" "40.2" "46.4" "42.5" "44.5" "62.7" "42.2" "36.7" "47.9" "103.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5568233219206595783" "False" "High" "IsMasterProtein" "Q9ULT8" "E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4" "0.000" "False" "10.632" "1" "3" "3" "3" "2610" "289.2" "5.35" "8.74" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf00632, Pf06701, Pf07738, Pf12796, Pf18410" "25831" "ENSG00000092148" "HECTD1" "D3DS86; hsa:25831; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; Q9ULT8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.964" "1.048" "0.853" "0.917" "0.997" "0.962" "0.893" "1.031" "2.159" "87.5" "84.3" "91.7" "74.6" "80.2" "87.2" "84.1" "78.1" "90.2" "188.9" "" "" "" "" "" "" "" "" "" "" "79.0" "65.1" "70.9" "50.2" "66.9" "74.5" "71.4" "56.5" "60.8" "188.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5783897718523636057" "False" "High" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "0.000" "False" "10.615" "2" "3" "3" "2" "1720" "194.7" "7.03" "9.07" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "1.081" "1.109" "1.077" "0.975" "1.208" "0.791" "0.875" "1.342" "1.493" "99.3" "107.3" "110.1" "106.9" "96.8" "119.9" "78.5" "86.9" "133.2" "148.2" "" "" "" "" "" "" "" "" "" "" "89.6" "82.8" "85.2" "72.0" "80.7" "102.4" "66.6" "62.9" "89.8" "148.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753763641550930270" "False" "High" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "0.000" "False" "10.600" "8" "2" "3" "2" "372" "42.0" "5.31" "11.08" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "17q12 copy number variation syndrome" "6" "0" "1.136" "1.084" "1.085" "1.037" "1.048" "1.009" "1.103" "1.227" "0.782" "217.6" "247.1" "235.9" "236.1" "225.6" "228.1" "219.6" "239.9" "267.0" "170.1" "" "" "" "" "" "" "" "" "" "" "196.4" "190.6" "182.4" "159.0" "188.2" "194.7" "186.2" "173.6" "180.1" "170.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4785395366368004219" "False" "High" "IsMasterProtein" "Q15274" "Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Homo sapiens OX=9606 GN=QPRT PE=1 SV=3" "0.000" "False" "10.600" "10" "3" "3" "3" "297" "30.8" "6.21" "9.48" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01729, Pf02749" "23475" "ENSG00000103485" "QPRT" "hsa:23475; Q15274; Q53XW7; Q96G22; Q9BSG6" "Nicotinate metabolism" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome; Kynurenine pathway and links to cell senescence" "5" "0" "0.914" "1.047" "1.125" "1.062" "1.015" "1.010" "0.973" "1.123" "0.841" "259.4" "237.0" "271.5" "291.8" "275.6" "263.2" "261.9" "252.3" "291.4" "218.0" "" "" "" "" "" "" "" "" "" "" "234.1" "182.8" "210.0" "196.5" "229.9" "224.7" "222.2" "182.6" "196.5" "218.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2873927276967630041" "False" "High" "IsMasterProtein" "Q2TAZ0" "Autophagy-related protein 2 homolog A OS=Homo sapiens OX=9606 GN=ATG2A PE=1 SV=3" "0.000" "False" "10.598" "2" "4" "4" "4" "1938" "212.7" "5.88" "10.49" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624" "23130" "ENSG00000110046" "ATG2A" "hsa:23130; O43154; Q14DM2; Q2TAZ0; Q6ZTV2; Q7Z6K8; Q8IVY5; Q8TAI8; Q96HH7" "" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "4" "0" "1.017" "0.677" "0.882" "0.953" "0.645" "0.773" "0.902" "0.766" "0.815" "48.1" "49.0" "32.6" "42.4" "45.9" "31.0" "37.2" "43.4" "36.9" "39.3" "" "" "" "" "" "" "" "" "" "" "43.5" "37.8" "25.2" "28.6" "38.3" "26.5" "31.6" "31.4" "24.9" "39.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7927368921331951811" "False" "High" "IsMasterProtein" "Cont_O46375" "Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1" "0.000" "True" "10.560" "22" "3" "4" "3" "147" "15.7" "6.30" "12.04" "3" "other metabolic processes;signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00576" "102267525; 104980319; 109577967; 280948" "ENSBGRG00000022634; ENSBIXG00000008920; ENSBIXG00005017301; ENSBTAG00000010991" "TTR" "A0A4W2BU20; A0A6B0QTW8; A0A6P3GKP7; A0A6P5DX06; A0A8B9YDR1; bbis:104980319; biu:109577967; bom:102267525; bta:280948; O46375; Q3SZ91" "Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "" "3" "0" "1.119" "1.051" "1.149" "1.012" "1.303" "1.086" "1.065" "1.309" "0.938" "279.3" "312.5" "293.4" "321.0" "282.7" "364.0" "303.3" "297.5" "365.5" "262.0" "" "" "" "" "" "" "" "" "" "" "252.1" "241.1" "227.0" "216.2" "235.8" "310.7" "257.3" "215.3" "246.5" "262.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5097662091813912850" "False" "High" "IsMasterProtein" "Q02252" "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Homo sapiens OX=9606 GN=ALDH6A1 PE=1 SV=2" "0.000" "False" "10.553" "6" "3" "3" "3" "535" "57.8" "8.50" "8.24" "3" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf00171" "4329" "ENSG00000119711" "ALDH6A1" "B2R609; B4DFS8; hsa:4329; J3KNU8; Q02252; Q9UKM8" "Branched-chain amino acid catabolism" "" "1" "0" "0.954" "0.586" "0.743" "0.727" "1.054" "0.859" "0.847" "0.880" "1.384" "20.3" "19.3" "11.9" "15.0" "14.7" "21.3" "17.4" "17.2" "17.8" "28.0" "" "" "" "" "" "" "" "" "" "" "18.3" "14.9" "9.2" "10.1" "12.3" "18.2" "14.8" "12.4" "12.0" "28.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669719094448447392" "False" "High" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "0.000" "False" "10.548" "3" "2" "4" "2" "1104" "122.8" "5.83" "7.99" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Glycosphingolipid transport; RHOF GTPase cycle" "" "7" "0" "0.992" "1.531" "0.920" "0.939" "1.391" "1.034" "0.970" "1.825" "2.106" "20.7" "20.5" "31.7" "19.1" "19.4" "28.8" "21.4" "20.1" "37.8" "43.6" "" "" "" "" "" "" "" "" "" "" "18.7" "15.8" "24.5" "12.8" "16.2" "24.6" "18.2" "14.5" "25.5" "43.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "67998593382130798" "False" "High" "IsMasterProtein" "O15131" "Importin subunit alpha-6 OS=Homo sapiens OX=9606 GN=KPNA5 PE=1 SV=3" "0.000" "False" "10.520" "4" "3" "4" "3" "539" "60.6" "5.12" "12.80" "3" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3841" "ENSG00000196911" "KPNA5" "B2RAI5; hsa:3841; O15131; Q86X23" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "" "2" "0" "0.903" "1.522" "0.863" "1.040" "1.222" "1.007" "0.849" "1.074" "4.054" "51.6" "46.6" "78.5" "44.5" "53.6" "63.0" "51.9" "43.8" "55.4" "209.0" "" "" "" "" "" "" "" "" "" "" "46.5" "35.9" "60.7" "30.0" "44.7" "53.8" "44.1" "31.7" "37.4" "209.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-618905356124197811" "False" "High" "IsMasterProtein" "Q9NQZ5" "StAR-related lipid transfer protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=STARD7 PE=1 SV=2" "0.000" "False" "10.518" "9" "3" "3" "3" "370" "43.1" "8.95" "7.97" "3" "" "other membranes;mitochondrion" "other molecular function" "Pf01852" "56910" "ENSG00000084090" "STARD7" "D3DXG9; hsa:56910; Q53T44; Q6GU43; Q969M6; Q9NQZ5" "Mitochondrial protein degradation; Synthesis of PC" "2q11.2 copy number variation syndrome" "3" "0" "1.092" "0.897" "0.921" "1.095" "0.845" "1.141" "0.933" "0.943" "1.515" "61.4" "67.1" "55.0" "56.6" "67.2" "51.9" "70.1" "57.3" "57.9" "93.0" "" "" "" "" "" "" "" "" "" "" "55.4" "51.7" "42.6" "38.1" "56.1" "44.3" "59.4" "41.5" "39.0" "93.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3574208382527803870" "False" "High" "IsMasterProtein" "Q9Y2X7" "ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2" "0.000" "False" "10.516" "5" "4" "5" "4" "761" "84.3" "6.80" "10.25" "4" "transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf12796, Pf16559" "28964" "ENSG00000108262" "GIT1" "B4DGU9; B4DSV3; hsa:28964; Q86SS0; Q9BRJ4; Q9Y2X7" "RHOJ GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs" "CAMKK2 pathway; Regulation of actin cytoskeleton" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286201540320348411" "False" "High" "IsMasterProtein" "Q92990" "Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2" "0.000" "False" "10.503" "6" "4" "4" "4" "594" "68.2" "5.33" "11.68" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf08568" "11146" "ENSG00000174842" "GLMN" "hsa:11146; Q5VVC3; Q92990; Q9BVE8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.800" "0.948" "1.394" "1.118" "0.951" "1.142" "0.737" "0.927" "1.231" "22.6" "18.1" "21.5" "31.5" "25.3" "21.5" "25.9" "16.7" "21.0" "27.8" "" "" "" "" "" "" "" "" "" "" "20.4" "14.0" "16.6" "21.2" "21.1" "18.4" "21.9" "12.1" "14.2" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2529735565303520700" "False" "High" "IsMasterProtein" "Q9BQS8" "FYVE and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FYCO1 PE=1 SV=3" "0.000" "False" "10.496" "3" "4" "5" "4" "1478" "166.9" "4.92" "14.84" "4" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "79443" "ENSG00000163820" "FYCO1" "B7ZKT7; hsa:79443; Q3MJE6; Q86T41; Q86TB1; Q8TEF9; Q96IV5; Q9BQS8; Q9H8P9" "" "Clock-controlled autophagy in bone metabolism" "1" "0" "0.965" "0.808" "1.099" "1.082" "0.820" "0.981" "0.952" "1.007" "1.521" "97.3" "93.9" "78.6" "106.9" "105.3" "79.8" "95.4" "92.6" "97.9" "148.0" "" "" "" "" "" "" "" "" "" "" "87.8" "72.4" "60.8" "72.0" "87.8" "68.1" "80.9" "67.0" "66.0" "148.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285089334394207834" "False" "High" "IsMasterProtein" "Q12959" "Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2" "0.000" "False" "10.488" "2" "2" "2" "2" "904" "100.4" "5.76" "7.18" "2" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf09058, Pf10600, Pf10608" "1739" "ENSG00000075711" "DLG1" "A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21; hsa:1739; Q12958; Q12959" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome; Cell lineage map for neuronal differentiation" "15" "0" "0.760" "0.934" "1.001" "1.070" "1.014" "0.855" "1.021" "1.192" "1.073" "45.8" "34.8" "42.8" "45.8" "49.0" "46.4" "39.1" "46.7" "54.5" "49.1" "" "" "" "" "" "" "" "" "" "" "41.3" "26.8" "33.1" "30.8" "40.9" "39.6" "33.2" "33.8" "36.8" "49.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "583939558635172856" "False" "High" "IsMasterProtein" "Q9Y4P1" "Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2" "0.000" "False" "10.486" "9" "3" "3" "3" "393" "44.3" "5.07" "7.99" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03416, Pf20166" "23192" "ENSG00000168397" "ATG4B" "B7WNK2; hsa:23192; Q53NU4; Q6ZUV8; Q8WYM9; Q96K07; Q96K96; Q96SZ1; Q9Y2F2; Q9Y4P1" "Macroautophagy" "2q37 copy number variation syndrome" "2" "0" "1.003" "1.088" "1.185" "0.951" "0.980" "0.855" "0.834" "1.116" "2.914" "86.1" "86.4" "93.6" "102.0" "81.9" "84.4" "73.6" "71.8" "96.1" "250.9" "" "" "" "" "" "" "" "" "" "" "77.7" "66.6" "72.4" "68.7" "68.3" "72.0" "62.4" "52.0" "64.8" "250.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227008394942671266" "False" "High" "IsMasterProtein" "Q9BUQ8" "Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3" "0.000" "False" "10.485" "5" "4" "4" "4" "820" "95.5" "9.55" "9.25" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "9416" "ENSG00000174243" "DDX23" "B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4713550819086734085" "False" "High" "IsMasterProtein" "Q96AT9" "Ribulose-phosphate 3-epimerase OS=Homo sapiens OX=9606 GN=RPE PE=1 SV=1" "0.000" "False" "10.480" "15" "3" "4" "3" "228" "24.9" "5.58" "12.63" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf00834" "6120" "ENSG00000197713" "RPE" "A8K4S0; B4E016; C9JPQ7; hsa:6120; O43767; Q53TV9; Q8N215; Q96AT9; Q96N34; Q9BSB5" "Pentose phosphate pathway" "Pentose phosphate metabolism; Pentose phosphate pathway in senescent cells" "3" "0" "0.937" "0.969" "0.989" "0.980" "0.911" "0.994" "1.067" "1.002" "0.620" "392.8" "368.2" "380.6" "388.7" "385.0" "357.8" "390.5" "419.0" "393.5" "243.5" "" "" "" "" "" "" "" "" "" "" "354.6" "284.0" "294.4" "261.8" "321.2" "305.4" "331.2" "303.2" "265.4" "243.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8027894993262294813" "False" "High" "IsMasterProtein" "Q13131" "5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4" "0.000" "False" "10.471" "4" "3" "3" "3" "559" "64.0" "8.12" "10.59" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf16579, Pf21147" "5562" "ENSG00000132356" "PRKAA1" "A8MTQ6; B2R7E1; hsa:5562; O00286; Q13131; Q5D0E1; Q86VS1; Q9UNQ4" "Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Thyroxine (thyroid hormone) production; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; mir-124 predicted interactions with cell cycle and differentiation ; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Insulin signaling; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Pleural mesothelioma; Affected pathways in Duchenne muscular dystrophy; ADHD and autism (ASD) linked metabolic pathways and SNP" "36" "0" "0.979" "0.948" "0.935" "0.991" "0.828" "0.959" "0.912" "0.845" "0.942" "245.6" "240.5" "232.8" "229.5" "243.2" "203.2" "235.5" "223.9" "207.4" "231.3" "" "" "" "" "" "" "" "" "" "" "221.7" "185.5" "180.0" "154.5" "202.9" "173.4" "199.7" "162.0" "139.9" "231.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3096317975956610268" "False" "High" "IsMasterProtein" "Q9HBL8" "NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1" "0.000" "False" "10.463" "8" "3" "3" "3" "299" "33.3" "7.52" "8.17" "3" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf05368" "57407" "ENSG00000153406; ENSG00000274684" "NMRAL1" "hsa:57407; Q9HBL8" "Urea cycle" "" "1" "0" "1.076" "1.060" "1.220" "1.268" "1.092" "1.119" "1.144" "1.164" "1.950" "79.7" "85.8" "84.5" "97.2" "101.1" "87.0" "89.2" "91.2" "92.8" "155.5" "" "" "" "" "" "" "" "" "" "" "72.0" "66.2" "65.3" "65.5" "84.3" "74.3" "75.7" "66.0" "62.6" "155.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7098201232450387464" "False" "High" "IsMasterProtein" "Q8N999" "RNA ligase 1 OS=Homo sapiens OX=9606 GN=RLIG1 PE=1 SV=2" "0.000" "False" "10.453" "7" "2" "2" "2" "325" "37.5" "7.06" "6.36" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "" "other molecular function" "Pf17720" "91298" "ENSG00000133641" "RLIG1" "Q569K5; Q6AWA8; Q6PEK5; Q8IYQ5; Q8N999; Q9NT75" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747633478491734615" "False" "High" "IsMasterProtein" "Q96BW5" "Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1" "0.000" "False" "10.439" "5" "2" "2" "2" "349" "39.0" "6.52" "8.90" "2" "other metabolic processes;other biological processes" "" "other molecular function" "Pf02126" "9317" "ENSG00000165983" "PTER" "B0YJ77; B3KTF5; D3DRU0; hsa:9317; Q96BW5; Q9BY46" "" "" "0" "0" "0.877" "0.938" "1.105" "1.046" "1.209" "0.822" "0.943" "1.108" "0.695" "96.6" "84.7" "90.6" "106.8" "101.0" "116.8" "79.4" "91.1" "107.0" "67.2" "" "" "" "" "" "" "" "" "" "" "87.2" "65.4" "70.0" "71.9" "84.3" "99.7" "67.3" "65.9" "72.2" "67.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1748573463469303870" "False" "High" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "0.000" "False" "10.439" "3" "2" "2" "1" "725" "81.3" "7.83" "6.71" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "Resolution of Sister Chromatid Cohesion; MHC class II antigen presentation; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation" "10" "0" "0.907" "0.633" "0.891" "0.963" "0.569" "0.815" "0.861" "0.717" "2.256" "137.9" "125.1" "87.3" "122.9" "132.8" "78.4" "112.4" "118.7" "98.8" "311.1" "" "" "" "" "" "" "" "" "" "" "124.5" "96.5" "67.5" "82.7" "110.7" "66.9" "95.4" "85.9" "66.7" "311.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3689423794866279404" "False" "High" "IsMasterProtein" "Q8N8A2" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3" "0.000" "False" "10.434" "2" "2" "2" "2" "993" "107.5" "6.30" "6.63" "2" "" "" "" "Pf12796" "91526" "ENSG00000065413" "ANKRD44" "hsa:91526; Q53SL9; Q6P480; Q86VL5; Q8IZ72; Q8N8A2; Q9UFA4" "" "" "0" "0" "1.223" "0.771" "1.096" "1.028" "0.805" "1.102" "0.975" "0.866" "1.180" "91.0" "111.3" "70.2" "99.7" "93.5" "73.3" "100.3" "88.8" "78.8" "107.4" "" "" "" "" "" "" "" "" "" "" "82.2" "85.9" "54.3" "67.2" "78.0" "62.6" "85.1" "64.2" "53.2" "107.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263352969811880337" "False" "High" "IsMasterProtein" "Q13432" "Protein unc-119 homolog A OS=Homo sapiens OX=9606 GN=UNC119 PE=1 SV=1" "0.000" "False" "10.425" "17" "4" "6" "3" "240" "26.9" "6.42" "12.25" "4" "cell-cell signaling;cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05351" "9094" "ENSG00000109103" "UNC119" "A8K8G4; F1T095; hsa:9094; O95126; Q13432" "" "Joubert syndrome; Ciliopathies" "2" "0" "1.096" "0.824" "1.090" "1.077" "1.091" "0.840" "0.579" "0.986" "5.331" "46.4" "50.9" "38.3" "50.6" "50.0" "50.6" "39.0" "26.9" "45.8" "247.4" "" "" "" "" "" "" "" "" "" "" "41.9" "39.2" "29.6" "34.1" "41.7" "43.2" "33.1" "19.4" "30.9" "247.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "567113707807287491" "False" "High" "IsMasterProtein" "Q8NBT2" "Kinetochore protein Spc24 OS=Homo sapiens OX=9606 GN=SPC24 PE=1 SV=3" "0.000" "False" "10.410" "13" "3" "3" "3" "197" "22.4" "4.70" "9.36" "3" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08286" "147841" "ENSG00000161888" "SPC24" "B4DZZ7; C9JGC4; hsa:147841; Q8NBT2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.872" "0.738" "1.044" "1.007" "0.675" "0.940" "1.051" "0.697" "2.063" "204.3" "178.2" "150.8" "213.3" "205.7" "137.9" "192.1" "214.7" "142.3" "421.6" "" "" "" "" "" "" "" "" "" "" "184.5" "137.4" "116.6" "143.7" "171.6" "117.7" "163.0" "155.4" "96.0" "421.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6200383293614890998" "False" "High" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "0.000" "False" "10.383" "22" "3" "9" "3" "103" "11.6" "5.27" "25.06" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "mRNA processing" "3" "0" "0.950" "1.043" "0.959" "0.937" "1.010" "0.876" "1.006" "1.085" "0.638" "981.4" "932.1" "1023.7" "940.8" "919.1" "991.3" "860.1" "987.5" "1064.4" "626.2" "" "" "" "" "" "" "" "" "" "" "885.9" "719.0" "791.8" "633.5" "766.7" "846.1" "729.6" "714.6" "717.9" "626.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970253198694079027" "False" "High" "IsMasterProtein" "Q96BW1" "Uracil phosphoribosyltransferase homolog OS=Homo sapiens OX=9606 GN=UPRT PE=1 SV=1" "0.000" "False" "10.376" "9" "3" "3" "3" "309" "33.8" "6.04" "9.16" "3" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf14681" "139596" "ENSG00000094841" "UPRT" "hsa:139596; Q5JRL1; Q5JRL3; Q68DN0; Q96BW1; Q96MW2" "" "Pyrimidine metabolism" "1" "0" "1.013" "0.807" "0.849" "0.903" "0.828" "0.989" "0.965" "0.929" "0.780" "299.5" "303.2" "241.7" "254.4" "270.6" "248.1" "296.3" "288.9" "278.2" "233.5" "" "" "" "" "" "" "" "" "" "" "270.3" "233.9" "186.9" "171.3" "225.7" "211.7" "251.3" "209.1" "187.7" "233.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023888813436623976" "False" "High" "IsMasterProtein" "O94760" "N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Homo sapiens OX=9606 GN=DDAH1 PE=1 SV=3" "0.000" "False" "10.357" "9" "3" "3" "3" "285" "31.1" "5.81" "8.30" "3" "other metabolic processes;signal transduction;other biological processes" "cytosol" "other molecular function" "Pf19420" "23576" "ENSG00000153904" "DDAH1" "hsa:23576; O94760; Q5HYC8; Q86XK5" "eNOS activation" "Mesodermal commitment pathway; Nitric oxide metabolism in cystic fibrosis" "3" "0" "1.079" "1.118" "1.017" "0.981" "1.045" "1.118" "1.005" "1.169" "0.719" "264.5" "285.3" "295.8" "269.1" "259.4" "276.5" "295.7" "265.9" "309.2" "190.1" "" "" "" "" "" "" "" "" "" "" "238.8" "220.1" "228.8" "181.2" "216.4" "236.0" "250.8" "192.4" "208.5" "190.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4929708673540461466" "False" "High" "IsMasterProtein" "Q9UHP3" "Ubiquitin carboxyl-terminal hydrolase 25 OS=Homo sapiens OX=9606 GN=USP25 PE=1 SV=4" "0.000" "False" "10.354" "2" "2" "2" "2" "1055" "122.1" "5.34" "7.73" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00443, Pf02809" "29761" "ENSG00000155313" "USP25" "C0LSZ0; hsa:29761; Q6DHZ9; Q9H9W1; Q9UHP3" "Ub-specific processing proteases" "" "1" "0" "1.018" "0.879" "1.044" "1.145" "0.912" "1.092" "1.024" "0.921" "1.267" "90.0" "91.6" "79.1" "93.9" "103.0" "82.0" "98.3" "92.1" "82.9" "114.0" "" "" "" "" "" "" "" "" "" "" "81.2" "70.6" "61.2" "63.3" "85.9" "70.0" "83.4" "66.7" "55.9" "114.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3910954529377130988" "False" "High" "IsMasterProtein" "Q9UPN3" "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4" "0.000" "False" "10.349" "1" "6" "6" "5" "7388" "837.8" "5.39" "13.63" "6" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "23499" "ENSG00000127603" "MACF1" "B1ALC5; E9PJT0; hsa:23499; O75053; Q5VW20; Q8WXY1; Q8WXY2; Q96PK2; Q9H540; Q9UKP0; Q9ULG9; Q9UPN3" "" "Mesodermal commitment pathway; Mesodermal commitment pathway" "2" "0" "0.910" "1.042" "1.177" "0.978" "0.923" "0.839" "0.749" "1.075" "1.769" "42.0" "38.2" "43.7" "49.4" "41.0" "38.7" "35.2" "31.4" "45.1" "74.2" "" "" "" "" "" "" "" "" "" "" "37.9" "29.5" "33.8" "33.2" "34.2" "33.1" "29.8" "22.7" "30.4" "74.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4910055014827061803" "False" "High" "IsMasterProtein" "Q14653" "Interferon regulatory factor 3 OS=Homo sapiens OX=9606 GN=IRF3 PE=1 SV=1" "0.000" "False" "10.345" "5" "2" "3" "2" "427" "47.2" "5.34" "7.53" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3661" "ENSG00000126456" "IRF3" "A8K7L2; B2RAZ3; hsa:3661; Q14653; Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6" "ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Interferon gamma signaling; Interferon alpha/beta signaling; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; IRF3 mediated activation of type 1 IFN" "Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Fibrin complement receptor 3 signaling pathway; White fat cell differentiation; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Urotensin-II-mediated signaling pathway; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; Toll-like receptor signaling pathway" "38" "0" "0.919" "0.911" "1.102" "1.088" "1.135" "1.190" "1.084" "1.018" "0.859" "28.4" "26.1" "25.9" "31.3" "30.9" "32.3" "33.9" "30.8" "29.0" "24.4" "" "" "" "" "" "" "" "" "" "" "25.7" "20.2" "20.0" "21.1" "25.8" "27.5" "28.7" "22.3" "19.5" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657262686538344528" "False" "High" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "0.000" "False" "10.341" "2" "2" "2" "2" "1129" "125.9" "5.62" "6.91" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894, Pf20946" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "" "Mesodermal commitment pathway" "1" "0" "0.983" "2.480" "1.855" "1.166" "2.395" "1.400" "0.796" "2.684" "5.137" "59.7" "58.6" "148.0" "110.7" "69.5" "142.9" "83.6" "47.5" "160.1" "306.5" "" "" "" "" "" "" "" "" "" "" "53.9" "45.2" "114.4" "74.5" "58.0" "121.9" "70.9" "34.4" "108.0" "306.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6333223318553199487" "False" "High" "IsMasterProtein" "Q14919" "Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3" "0.000" "False" "10.336" "9" "2" "3" "2" "205" "22.3" "5.17" "8.43" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00808" "10589" "ENSG00000175550" "DRAP1" "hsa:10589; Q13448; Q14919" "Signaling by NODAL; Signaling by Activin" "" "2" "0" "0.960" "0.770" "0.832" "0.922" "0.785" "0.858" "0.909" "0.895" "0.646" "136.6" "131.2" "105.2" "113.7" "125.9" "107.2" "117.2" "124.2" "122.3" "88.3" "" "" "" "" "" "" "" "" "" "" "123.3" "101.2" "81.4" "76.5" "105.1" "91.5" "99.4" "89.9" "82.5" "88.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697554350722155722" "False" "High" "IsMasterProtein" "Q96B45" "BLOC-1-related complex subunit 7 OS=Homo sapiens OX=9606 GN=BORCS7 PE=1 SV=2" "0.000" "False" "10.326" "22" "2" "2" "2" "106" "11.7" "6.79" "6.56" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf16088" "119032" "ENSG00000166275" "BORCS7" "B2R488; B3KUW4; C9K0X3; hsa:119032; Q96B45" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4381387929152042020" "False" "High" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "0.000" "False" "10.280" "11" "4" "4" "4" "412" "46.6" "7.18" "11.07" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "0.969" "0.908" "1.048" "1.157" "0.948" "1.067" "1.032" "0.830" "1.702" "186.0" "180.3" "168.8" "194.8" "215.1" "176.4" "198.5" "191.8" "154.4" "316.6" "" "" "" "" "" "" "" "" "" "" "167.9" "139.1" "130.6" "131.2" "179.4" "150.5" "168.4" "138.8" "104.1" "316.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6481945204603063978" "False" "High" "IsMasterProtein" "Q9UBB6" "Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1" "0.000" "False" "10.278" "5" "3" "4" "3" "729" "78.8" "5.48" "9.63" "3" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf05536" "23154" "ENSG00000020129" "NCDN" "D3DPR9; hsa:23154; Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9" "" "Splicing factor NOVA regulated synaptic proteins" "1" "0" "1.116" "1.041" "1.349" "0.989" "0.874" "1.133" "0.935" "1.063" "1.174" "69.1" "77.1" "71.9" "93.2" "68.3" "60.4" "78.2" "64.6" "73.4" "81.1" "" "" "" "" "" "" "" "" "" "" "62.3" "59.5" "55.6" "62.8" "57.0" "51.5" "66.4" "46.7" "49.5" "81.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1944115724239200420" "False" "High" "IsMasterProtein" "O43310" "CBP80/20-dependent translation initiation factor OS=Homo sapiens OX=9606 GN=CTIF PE=1 SV=1" "0.000" "False" "10.277" "5" "3" "4" "3" "598" "67.5" "6.54" "9.16" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854" "9811" "ENSG00000134030; ENSG00000282825" "CTIF" "B3KTR8; hsa:9811; O43310; Q8IVD5" "" "" "0" "0" "1.051" "0.800" "0.971" "0.995" "0.975" "1.047" "1.058" "0.967" "0.828" "105.0" "110.4" "84.1" "102.0" "104.4" "102.4" "110.0" "111.2" "101.6" "86.9" "" "" "" "" "" "" "" "" "" "" "94.8" "85.2" "65.0" "68.7" "87.1" "87.4" "93.3" "80.4" "68.5" "86.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4828769571271312822" "False" "High" "IsMasterProtein" "P46108" "Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2" "0.000" "False" "10.271" "10" "3" "3" "3" "304" "33.8" "5.55" "7.76" "3" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00017, Pf00018, Pf07653" "1398" "ENSG00000167193" "CRK" "A8MWE8; B0LPE8; D3DTH6; hsa:1398; P46108; Q96GA9; Q96HJ0" "FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; GDNF signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "31" "0" "0.980" "0.719" "0.892" "0.768" "0.816" "0.719" "0.588" "0.644" "1.465" "44.3" "43.4" "31.8" "39.5" "34.0" "36.1" "31.8" "26.0" "28.5" "64.8" "" "" "" "" "" "" "" "" "" "" "40.0" "33.5" "24.6" "26.6" "28.4" "30.8" "27.0" "18.8" "19.2" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "938742805709954505" "False" "High" "IsMasterProtein" "Q9H3F6" "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1" "0.000" "False" "10.269" "14" "4" "4" "4" "313" "35.4" "6.34" "8.80" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02214" "83892" "ENSG00000110906" "KCTD10" "hsa:83892; Q53HN2; Q59FV1; Q6PL47; Q96SU0; Q9H3F6" "" "" "0" "0" "1.101" "0.943" "0.935" "1.029" "0.975" "1.020" "1.143" "0.970" "0.827" "117.0" "128.8" "110.3" "109.4" "120.3" "114.0" "119.3" "133.7" "113.5" "96.7" "" "" "" "" "" "" "" "" "" "" "105.6" "99.3" "85.3" "73.7" "100.4" "97.3" "101.2" "96.7" "76.5" "96.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7633283186484640293" "False" "High" "IsMasterProtein" "Q06547" "GA-binding protein subunit beta-1 OS=Homo sapiens OX=9606 GN=GABPB1 PE=1 SV=2" "0.000" "False" "10.268" "6" "3" "4" "3" "395" "42.5" "4.86" "12.03" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "2553" "ENSG00000104064" "GABPB1" "A8IE52; hsa:2553; Q06545; Q06547; Q12940; Q12941; Q12942; Q8IYD0" "" "Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression" "3" "0" "0.939" "1.574" "0.908" "0.951" "1.724" "0.947" "0.859" "1.579" "2.453" "227.1" "213.2" "357.4" "206.2" "215.9" "391.5" "215.0" "195.1" "358.7" "557.1" "" "" "" "" "" "" "" "" "" "" "205.0" "164.4" "276.4" "138.9" "180.1" "334.2" "182.4" "141.2" "241.9" "557.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316251485158664462" "False" "High" "IsMasterProtein" "Q8N8A6" "ATP-dependent RNA helicase DDX51 OS=Homo sapiens OX=9606 GN=DDX51 PE=1 SV=3" "0.000" "False" "10.251" "2" "1" "2" "1" "666" "72.4" "8.16" "6.71" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "317781" "ENSG00000185163; ENSG00000288503" "DDX51" "A8MPT9; hsa:317781; Q5CZ71; Q8IXK5; Q8N8A6; Q96ED1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5140965250815444674" "False" "High" "IsMasterProtein" "Q9ULJ6" "Zinc finger MIZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZMIZ1 PE=1 SV=3" "0.000" "False" "10.246" "2" "3" "5" "2" "1067" "115.4" "7.46" "14.74" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02891, Pf18028" "57178" "ENSG00000108175" "ZMIZ1" "hsa:57178; Q5JSH9; Q7Z7E6; Q9ULJ6" "" "Androgen receptor signaling pathway" "1" "1" "1.057" "0.780" "0.948" "1.036" "0.824" "0.988" "0.960" "0.830" "0.772" "323.2" "341.7" "252.1" "306.4" "335.0" "266.3" "319.4" "310.4" "268.2" "249.5" "" "" "" "" "" "" "" "" "" "" "291.7" "263.6" "194.9" "206.3" "279.4" "227.3" "270.9" "224.6" "180.9" "249.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1229807806236447203" "False" "High" "IsMasterProtein" "Q7Z7L1" "Schlafen family member 11 OS=Homo sapiens OX=9606 GN=SLFN11 PE=1 SV=2" "0.000" "False" "10.246" "4" "3" "3" "3" "901" "102.8" "7.77" "8.23" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04326, Pf09848, Pf17057, Pf21026" "91607" "ENSG00000172716" "SLFN11" "E1P643; hsa:91607; Q7Z7L1; Q8N3S8; Q8N762; Q8TEE0" "" "17q12 copy number variation syndrome" "1" "0" "0.838" "0.726" "1.135" "0.950" "0.546" "0.988" "0.864" "0.678" "2.490" "62.6" "52.4" "45.4" "71.0" "59.5" "34.2" "61.8" "54.0" "42.4" "155.7" "" "" "" "" "" "" "" "" "" "" "56.5" "40.4" "35.1" "47.8" "49.6" "29.2" "52.4" "39.1" "28.6" "155.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "472644769200762840" "False" "High" "IsMasterProtein" "Q9UJK0" "18S rRNA aminocarboxypropyltransferase OS=Homo sapiens OX=9606 GN=TSR3 PE=1 SV=1" "0.000" "False" "10.239" "12" "3" "4" "3" "312" "33.6" "6.87" "9.82" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf04034, Pf04068" "115939" "ENSG00000007520" "TSR3" "hsa:115939; Q6PJT8; Q9UJK0" "rRNA modification in the nucleus and cytosol" "" "1" "0" "1.108" "1.196" "1.347" "1.104" "1.148" "1.142" "1.074" "1.059" "0.881" "72.7" "80.6" "87.0" "98.0" "80.3" "83.5" "83.0" "78.1" "77.0" "64.1" "" "" "" "" "" "" "" "" "" "" "65.6" "62.2" "67.3" "66.0" "67.0" "71.2" "70.4" "56.5" "52.0" "64.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4578961420069997890" "False" "High" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "0.000" "False" "10.222" "4" "2" "2" "2" "480" "52.6" "6.37" "7.11" "2" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735333771594595677" "False" "High" "IsMasterProtein" "Q9BYN8" "Small ribosomal subunit protein mS26 OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" "0.000" "False" "10.197" "16" "4" "4" "4" "205" "24.2" "10.39" "8.95" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf14943" "64949" "ENSG00000125901" "MRPS26" "hsa:64949; Q96Q58; Q9BYN8" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.973" "0.838" "0.960" "1.093" "0.831" "1.041" "0.884" "0.849" "1.136" "255.8" "248.8" "214.3" "245.5" "279.7" "212.5" "266.3" "226.0" "217.2" "290.6" "" "" "" "" "" "" "" "" "" "" "230.9" "191.9" "165.7" "165.3" "233.3" "181.4" "225.9" "163.6" "146.5" "290.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657914547001490376" "False" "High" "IsMasterProtein" "P53778" "Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3" "0.000" "False" "10.179" "5" "2" "4" "1" "367" "41.9" "6.39" "12.65" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6300" "ENSG00000188130" "MAPK12" "hsa:6300; P53778; Q14260; Q6IC53; Q99588; Q99672" "VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Negative regulation of MAPK pathway" "Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway" "30" "0" "1.228" "0.825" "1.124" "1.014" "1.031" "1.012" "1.056" "1.132" "0.774" "80.8" "99.2" "66.6" "90.8" "81.9" "83.3" "81.8" "85.3" "91.5" "62.5" "" "" "" "" "" "" "" "" "" "" "72.9" "76.5" "51.5" "61.1" "68.3" "71.1" "69.4" "61.7" "61.7" "62.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3913128170310311305" "False" "High" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "0.000" "False" "10.161" "12" "4" "9" "4" "310" "34.6" "6.52" "23.84" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "64" "0" "1.111" "0.853" "0.968" "0.995" "0.795" "1.102" "1.143" "0.774" "0.916" "1014.4" "1126.8" "864.9" "981.8" "1009.8" "806.0" "1117.5" "1159.7" "785.7" "928.8" "" "" "" "" "" "" "" "" "" "" "915.7" "869.2" "669.0" "661.1" "842.3" "687.9" "948.0" "839.3" "529.9" "928.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4879216047058048587" "False" "High" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "0.000" "False" "10.142" "20" "2" "2" "2" "110" "11.3" "6.54" "6.25" "2" "protein metabolism;stress response;transport" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "Antimicrobial peptides" "" "1" "0" "4.119" "2.758" "1.055" "1.778" "3.101" "1.272" "0.988" "2.232" "1.107" "51.5" "212.1" "142.0" "54.3" "91.5" "159.6" "65.5" "50.9" "114.9" "57.0" "" "" "" "" "" "" "" "" "" "" "46.5" "163.6" "109.8" "36.6" "76.3" "136.3" "55.6" "36.8" "77.5" "57.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308881138529098641" "False" "High" "IsMasterProtein" "Q9Y244" "Proteasome maturation protein OS=Homo sapiens OX=9606 GN=POMP PE=1 SV=1" "0.000" "False" "10.129" "15" "1" "1" "1" "141" "15.8" "5.11" "5.81" "1" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf05348" "51371" "ENSG00000132963" "POMP" "A5HKJ2; D6MXU3; hsa:51371; Q9HB69; Q9Y244" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526425454586707099" "False" "High" "IsMasterProtein" "Q8TE02" "Elongator complex protein 5 OS=Homo sapiens OX=9606 GN=ELP5 PE=1 SV=3" "0.000" "False" "10.128" "11" "3" "4" "3" "300" "33.2" "4.98" "12.72" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10483" "23587" "ENSG00000170291; ENSG00000288485" "ELP5" "A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q8TE02; Q9BUB2; Q9Y2Q4" "HATs acetylate histones" "" "1" "0" "0.902" "0.981" "1.092" "0.922" "0.775" "1.082" "0.902" "0.923" "0.828" "66.1" "59.7" "64.9" "72.2" "61.0" "51.3" "71.5" "59.7" "61.0" "54.8" "" "" "" "" "" "" "" "" "" "" "59.7" "46.0" "50.2" "48.6" "50.9" "43.8" "60.7" "43.2" "41.2" "54.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8443546389451323737" "False" "High" "IsMasterProtein" "Q96HJ9" "Protein FMC1 homolog OS=Homo sapiens OX=9606 GN=FMC1 PE=1 SV=2" "0.000" "False" "10.122" "11" "1" "2" "1" "113" "12.7" "10.07" "6.11" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "" "Pf13233" "100996928; 154791" "ENSG00000164898" "FMC1" "B7Z4Q3; hsa:100996928; hsa:154791; Q75M90; Q96HJ9; Q9P0B3" "" "" "0" "0" "1.833" "1.486" "1.329" "1.578" "1.681" "1.363" "1.560" "1.465" "0.820" "13.2" "24.2" "19.6" "17.5" "20.8" "22.2" "18.0" "20.6" "19.3" "10.8" "" "" "" "" "" "" "" "" "" "" "11.9" "18.6" "15.2" "11.8" "17.4" "18.9" "15.2" "14.9" "13.0" "10.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6073254106150692843" "False" "High" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "0.000" "False" "10.115" "4" "5" "5" "5" "1024" "114.6" "9.22" "13.25" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; Q15037; Q99575" "tRNA processing in the nucleus" "" "1" "0" "0.949" "1.060" "1.066" "1.069" "0.982" "1.076" "1.018" "1.009" "0.780" "351.3" "333.3" "372.3" "374.6" "375.7" "345.1" "378.0" "357.7" "354.4" "273.9" "" "" "" "" "" "" "" "" "" "" "317.1" "257.1" "287.9" "252.3" "313.4" "294.5" "320.6" "258.9" "239.1" "273.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8918324511185795548" "False" "High" "IsMasterProtein" "Q9BVC4" "Target of rapamycin complex subunit LST8 OS=Homo sapiens OX=9606 GN=MLST8 PE=1 SV=1" "0.000" "False" "10.077" "6" "1" "1" "1" "326" "35.9" "5.86" "6.24" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00400" "64223" "ENSG00000167965" "MLST8" "B3KMM4; B4DY00; D3DU88; hsa:64223; Q5M800; Q86Y18; Q8WUI5; Q9BVC4; Q9HA66; Q9UJV6" "Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "34" "0" "0.759" "0.619" "1.036" "0.775" "0.875" "0.777" "0.619" "0.875" "1.064" "38.2" "29.0" "23.7" "39.6" "29.6" "33.5" "29.7" "23.7" "33.5" "40.7" "" "" "" "" "" "" "" "" "" "" "34.5" "22.4" "18.3" "26.7" "24.7" "28.6" "25.2" "17.1" "22.6" "40.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6883874888390724890" "False" "High" "IsMasterProtein" "Q5VTL8" "Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1" "0.000" "False" "10.071" "7" "4" "5" "4" "546" "64.4" "10.54" "13.52" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371" "55119" "ENSG00000134186" "PRPF38B" "hsa:55119; Q05DD6; Q32Q58; Q5VTL8; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7500811780682688662" "False" "High" "IsMasterProtein" "Q8N8S7" "Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2" "0.000" "False" "10.068" "4" "2" "3" "2" "591" "66.5" "6.93" "7.11" "2" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "55740" "ENSG00000154380" "ENAH" "D0PQI2; hsa:55740; Q502W5; Q5T5M7; Q5VTQ9; Q5VTR0; Q8N8S7; Q9NVF3; Q9UFB8" "Generation of second messenger molecules; Signaling by ROBO receptors" "Regulation of actin cytoskeleton" "3" "0" "0.912" "0.971" "0.713" "0.859" "0.758" "0.976" "1.007" "0.884" "1.425" "84.1" "76.7" "81.7" "60.0" "72.3" "63.8" "82.1" "84.7" "74.4" "119.8" "" "" "" "" "" "" "" "" "" "" "75.9" "59.2" "63.2" "40.4" "60.3" "54.4" "69.6" "61.3" "50.2" "119.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-428002072210945893" "False" "High" "IsMasterProtein" "P52657" "Transcription initiation factor IIA subunit 2 OS=Homo sapiens OX=9606 GN=GTF2A2 PE=1 SV=1" "0.000" "False" "10.055" "28" "4" "4" "4" "109" "12.4" "6.62" "11.87" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02268, Pf02751" "2958" "ENSG00000140307" "GTF2A2" "A8MYQ7; hsa:2958; P52657; Q6FGB5" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "Eukaryotic transcription initiation" "11" "0" "1.092" "1.076" "0.980" "1.092" "1.212" "1.103" "0.992" "1.107" "0.695" "264.1" "288.5" "284.2" "258.8" "288.3" "320.1" "291.2" "262.1" "292.3" "183.5" "" "" "" "" "" "" "" "" "" "" "238.4" "222.5" "219.8" "174.3" "240.5" "273.2" "247.0" "189.7" "197.2" "183.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7211345083341158849" "False" "High" "IsMasterProtein" "Q15382" "GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1" "0.000" "False" "10.036" "14" "3" "4" "3" "184" "20.5" "5.92" "14.09" "3" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "6009" "ENSG00000106615" "RHEB" "B3KWN6; D3DX13; hsa:6009; Q15382; Q53Y56; Q99444" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Polycystic kidney disease pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway" "26" "0" "1.015" "0.951" "1.060" "1.048" "1.016" "1.023" "0.977" "1.011" "0.796" "494.0" "501.4" "469.6" "523.6" "517.6" "501.9" "505.3" "482.8" "499.5" "393.1" "" "" "" "" "" "" "" "" "" "" "445.9" "386.7" "363.2" "352.6" "431.8" "428.4" "428.6" "349.4" "336.9" "393.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-377515032386624778" "False" "High" "IsMasterProtein" "P78346" "Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1" "0.000" "False" "10.036" "14" "4" "5" "4" "268" "29.3" "8.91" "13.16" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01876" "10556" "ENSG00000148688" "RPP30" "B2R799; E9PB02; hsa:10556; P78346" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "" "2" "0" "0.987" "1.020" "1.127" "1.091" "1.055" "0.970" "1.057" "1.036" "0.842" "136.7" "134.9" "139.4" "154.0" "149.1" "144.2" "132.6" "144.4" "141.6" "115.1" "" "" "" "" "" "" "" "" "" "" "123.4" "104.1" "107.8" "103.7" "124.4" "123.1" "112.5" "104.5" "95.5" "115.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6240337966017765757" "False" "High" "IsMasterProtein" "Q0VDG4" "Secernin-3 OS=Homo sapiens OX=9606 GN=SCRN3 PE=1 SV=1" "0.000" "False" "10.028" "6" "2" "2" "2" "424" "48.5" "5.55" "6.15" "2" "protein metabolism" "" "other molecular function" "Pf03577" "79634" "ENSG00000144306" "SCRN3" "B4DI11; C9JPC1; D3DPE0; hsa:79634; Q0VDG4; Q7L1C5; Q9H5R5" "" "" "0" "0" "0.851" "1.131" "0.842" "1.142" "0.967" "0.935" "1.129" "0.978" "0.897" "50.8" "43.3" "57.5" "42.8" "58.0" "49.1" "47.5" "57.4" "49.7" "45.6" "" "" "" "" "" "" "" "" "" "" "45.9" "33.4" "44.5" "28.8" "48.4" "41.9" "40.3" "41.5" "33.5" "45.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687801448742430149" "False" "High" "IsMasterProtein" "Q9H4A6" "Golgi phosphoprotein 3 OS=Homo sapiens OX=9606 GN=GOLPH3 PE=1 SV=1" "0.000" "False" "10.024" "5" "1" "5" "1" "298" "33.8" "6.44" "15.99" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05719" "64083" "ENSG00000113384" "GOLPH3" "hsa:64083; Q9H4A6; Q9UIW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7525494529212049263" "False" "High" "IsMasterProtein" "O43149" "Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6" "0.000" "False" "10.013" "1" "2" "2" "2" "2961" "330.9" "5.95" "7.19" "2" "cell organization and biogenesis" "" "other molecular function" "Pf00569, Pf03256" "23140" "ENSG00000074755" "ZZEF1" "A7MBM5; hsa:23140; O43149; Q6NXG0; Q6ZRA1; Q6ZSF4; Q9NVB9" "" "" "0" "0" "1.164" "0.866" "1.049" "1.141" "0.875" "1.062" "0.972" "0.957" "1.028" "151.1" "175.9" "130.8" "158.4" "172.4" "132.2" "160.5" "146.8" "144.6" "155.3" "" "" "" "" "" "" "" "" "" "" "136.4" "135.6" "101.2" "106.7" "143.8" "112.8" "136.2" "106.3" "97.5" "155.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3637812855525000132" "False" "High" "IsMasterProtein" "Q2KHR2" "DNA-binding protein RFX7 OS=Homo sapiens OX=9606 GN=RFX7 PE=1 SV=2" "0.000" "False" "9.994" "2" "2" "2" "2" "1460" "157.3" "6.61" "6.44" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257" "64864" "ENSG00000181827" "RFX7" "hsa:64864; Q2KHR2; Q6ZRR1; Q6ZTY6; Q8N3J0; Q9H7A9; Q9H956" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828949100496623215" "False" "High" "IsMasterProtein" "Q92844" "TRAF family member-associated NF-kappa-B activator OS=Homo sapiens OX=9606 GN=TANK PE=1 SV=2" "0.000" "False" "9.984" "8" "3" "3" "3" "425" "47.8" "5.68" "8.97" "3" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf12845" "10010" "ENSG00000136560" "TANK" "D3DPB5; hsa:10010; Q7Z4J6; Q92844; Q92885" "Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF6 mediated IRF7 activation" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Novel intracellular components of RIG-I-like receptor pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "7" "0" "1.021" "1.050" "0.898" "0.974" "1.040" "0.991" "0.867" "0.967" "1.584" "72.6" "74.1" "76.3" "65.3" "70.7" "75.5" "72.0" "63.0" "70.2" "115.0" "" "" "" "" "" "" "" "" "" "" "65.6" "57.2" "59.0" "43.9" "59.0" "64.5" "61.1" "45.6" "47.4" "115.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3534429540462627294" "False" "High" "IsMasterProtein" "P09525" "Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4" "0.000" "False" "9.961" "11" "4" "9" "3" "319" "35.9" "6.13" "21.59" "4" "signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "307" "ENSG00000196975" "ANXA4" "B4DDF9; hsa:307; P09525; Q6LES2; Q96F33; Q9BWK1" "" "Prostaglandin synthesis and regulation" "1" "0" "0.840" "1.305" "1.041" "1.091" "1.319" "0.939" "0.662" "1.252" "1.125" "75.9" "63.8" "99.1" "79.0" "82.9" "100.1" "71.3" "50.3" "95.1" "85.5" "" "" "" "" "" "" "" "" "" "" "68.5" "49.2" "76.6" "53.2" "69.1" "85.5" "60.5" "36.4" "64.1" "85.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1178215793923997367" "False" "High" "IsMasterProtein" "Q96DM3" "Regulator of MON1-CCZ1 complex OS=Homo sapiens OX=9606 GN=RMC1 PE=1 SV=2" "0.000" "False" "9.959" "3" "2" "2" "2" "657" "74.9" "7.83" "7.39" "2" "other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle" "" "Pf07035, Pf21029" "29919" "ENSG00000141452" "RMC1" "Q96DM3; Q9BU17; Q9Y5M0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1701299476432316153" "False" "High" "IsMasterProtein" "Q9BU61" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1" "0.000" "False" "9.949" "12" "2" "3" "2" "184" "20.3" "8.22" "9.46" "2" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf04430" "25915" "ENSG00000178057" "NDUFAF3" "hsa:25915; Q9BU61" "Complex I biogenesis" "" "1" "0" "1.028" "1.192" "1.155" "1.213" "1.102" "1.138" "1.070" "1.231" "0.914" "76.3" "78.4" "90.9" "88.1" "92.5" "84.1" "86.8" "81.6" "93.9" "69.7" "" "" "" "" "" "" "" "" "" "" "68.9" "60.5" "70.3" "59.3" "77.2" "71.8" "73.7" "59.1" "63.3" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5839197527488627088" "False" "High" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "0.000" "False" "9.948" "5" "2" "3" "2" "424" "44.3" "8.44" "9.47" "2" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "11" "0" "1.142" "0.899" "1.071" "1.003" "0.910" "0.980" "0.957" "0.960" "0.728" "182.0" "207.8" "163.7" "194.9" "182.5" "165.7" "178.3" "174.2" "174.7" "132.6" "" "" "" "" "" "" "" "" "" "" "164.3" "160.3" "126.6" "131.3" "152.3" "141.4" "151.3" "126.1" "117.9" "132.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-597243898993742241" "False" "High" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "0.000" "False" "9.937" "16" "2" "4" "2" "107" "11.7" "10.32" "12.76" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "13" "0" "1.192" "1.333" "1.208" "1.169" "1.194" "1.143" "1.307" "1.312" "0.957" "366.7" "437.1" "488.6" "443.1" "428.8" "437.6" "419.2" "479.4" "481.0" "351.0" "" "" "" "" "" "" "" "" "" "" "331.0" "337.1" "377.9" "298.4" "357.7" "373.5" "355.6" "347.0" "324.4" "351.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2097918301010195378" "False" "High" "IsMasterProtein" "P28715" "DNA excision repair protein ERCC-5 OS=Homo sapiens OX=9606 GN=ERCC5 PE=1 SV=3" "0.000" "False" "9.933" "2" "2" "2" "2" "1186" "133.0" "5.22" "7.75" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2073" "ENSG00000134899" "ERCC5" "A6NGT4; hsa:2073; P28715; Q5JUS4; Q5JUS5; Q7Z2V3; Q8IZL6; Q8N1B7; Q9HD59; Q9HD60" "Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; 10q11.21q11.23 copy number variation syndrome" "7" "0" "1.088" "1.269" "1.017" "1.035" "1.132" "1.035" "1.019" "1.275" "1.369" "149.6" "162.7" "189.9" "152.1" "154.9" "169.4" "154.8" "152.4" "190.8" "204.9" "" "" "" "" "" "" "" "" "" "" "135.1" "125.5" "146.9" "102.4" "129.2" "144.6" "131.3" "110.3" "128.7" "204.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6138498598484703965" "False" "High" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "0.000" "False" "9.929" "19" "5" "5" "3" "207" "22.0" "9.38" "14.07" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "2" "0" "1.097" "1.235" "0.852" "1.047" "1.279" "0.947" "1.130" "1.343" "0.635" "37.3" "41.0" "46.1" "31.8" "39.1" "47.7" "35.4" "42.2" "50.2" "23.7" "" "" "" "" "" "" "" "" "" "" "33.7" "31.6" "35.7" "21.4" "32.6" "40.8" "30.0" "30.5" "33.8" "23.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6887775823956767803" "False" "High" "IsMasterProtein" "P25440" "Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2" "0.000" "False" "9.910" "2" "1" "1" "1" "801" "88.0" "9.09" "4.61" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf17035" "6046" "ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307" "BRD2" "A2AAU0; B0S7P0; B1AZT1; O00699; O00700; P25440; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4" "RUNX3 regulates p14-ARF" "" "1" "0" "0.711" "2.005" "0.881" "0.828" "2.143" "0.825" "0.700" "2.055" "3.700" "42.0" "29.8" "84.1" "37.0" "34.7" "89.9" "34.6" "29.4" "86.2" "155.2" "" "" "" "" "" "" "" "" "" "" "37.9" "23.0" "65.1" "24.9" "29.0" "76.8" "29.4" "21.3" "58.2" "155.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857120018545354279" "False" "High" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "0.000" "False" "9.906" "7" "2" "4" "2" "380" "42.1" "5.63" "12.06" "2" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "Separation of Sister Chromatids; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; SUMOylation of chromatin organization proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "" "35" "0" "1.382" "0.800" "1.279" "0.979" "1.089" "0.732" "0.904" "1.078" "0.935" "14.0" "19.3" "11.2" "17.9" "13.7" "15.2" "10.2" "12.6" "15.1" "13.1" "" "" "" "" "" "" "" "" "" "" "12.6" "14.9" "8.6" "12.0" "11.4" "13.0" "8.7" "9.1" "10.2" "13.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7216673517695953879" "False" "High" "IsMasterProtein" "Q8TDZ2" "[F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2" "0.000" "False" "9.875" "2" "2" "3" "2" "1067" "117.8" "6.40" "11.19" "2" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "64780" "ENSG00000135596" "MICAL1" "B7Z3R5; E1P5F0; Q7Z633; Q8IVS9; Q8TDZ2; Q96G47; Q9H6X6; Q9H7I0; Q9HAA1; Q9UFF7" "Factors involved in megakaryocyte development and platelet production" "" "1" "0" "1.061" "1.523" "0.970" "0.904" "1.449" "0.926" "0.688" "1.717" "3.987" "112.4" "119.3" "171.3" "109.1" "101.6" "162.9" "104.1" "77.3" "193.0" "448.3" "" "" "" "" "" "" "" "" "" "" "101.5" "92.0" "132.5" "73.5" "84.8" "139.0" "88.3" "56.0" "130.2" "448.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973813700341614243" "False" "High" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "0.000" "False" "9.864" "5" "3" "4" "2" "655" "74.3" "6.16" "12.21" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "Replacement of protamines by nucleosomes in the male pronucleus; Maturation of nucleoprotein" "VEGFA-VEGFR2 signaling; mRNA processing" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1845786618234347704" "False" "High" "IsMasterProtein" "P55263" "Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2" "0.000" "False" "9.851" "7" "3" "5" "3" "362" "40.5" "6.70" "11.63" "3" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "132" "ENSG00000156110" "ADK" "B7Z783; B7Z800; hsa:132; O00741; O00742; P55263; Q16710; Q5JQ10; Q5JQ11; Q9BTN2" "Ribavirin ADME; Purine salvage" "Methionine metabolism leading to sulfur amino acids and related disorders" "3" "0" "1.046" "0.885" "1.039" "0.900" "0.999" "0.999" "1.060" "0.942" "0.902" "288.6" "301.9" "255.3" "299.9" "259.8" "288.3" "288.3" "305.8" "271.9" "260.4" "" "" "" "" "" "" "" "" "" "" "260.5" "232.9" "197.5" "202.0" "216.7" "246.0" "244.6" "221.3" "183.4" "260.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1025854285268432181" "False" "High" "IsMasterProtein" "P56377" "AP-1 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP1S2 PE=1 SV=1" "0.000" "False" "9.847" "15" "2" "3" "1" "157" "18.6" "5.47" "11.66" "2" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "8905" "ENSG00000182287" "AP1S2" "B4DSU4; hsa:8905; O95326; P56377; Q9H2N6" "Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "0" "0.805" "0.969" "1.164" "1.060" "1.079" "0.823" "0.908" "1.062" "1.572" "36.2" "29.2" "35.1" "42.2" "38.4" "39.1" "29.8" "32.9" "38.5" "57.0" "" "" "" "" "" "" "" "" "" "" "32.7" "22.5" "27.2" "28.4" "32.0" "33.4" "25.3" "23.8" "26.0" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626223979709161938" "False" "High" "IsMasterProtein" "Q9NXX6" "Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens OX=9606 GN=NSMCE4A PE=1 SV=2" "0.000" "False" "9.845" "7" "3" "3" "3" "385" "44.3" "5.38" "9.27" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf08743, Pf15412" "54780" "ENSG00000107672" "NSMCE4A" "hsa:54780; Q5SQQ5; Q6P673; Q8WY66; Q9BS90; Q9NXX6" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "1.062" "1.015" "1.054" "1.062" "0.837" "1.113" "1.072" "1.070" "1.016" "140.3" "148.9" "142.5" "147.9" "149.0" "117.5" "156.2" "150.5" "150.1" "142.5" "" "" "" "" "" "" "" "" "" "" "126.6" "114.9" "110.2" "99.6" "124.3" "100.3" "132.5" "108.9" "101.2" "142.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359022296663299879" "False" "High" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "0.000" "False" "9.840" "4" "3" "3" "3" "630" "70.9" "8.09" "9.96" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "Termination of translesion DNA synthesis; ISG15 antiviral mechanism; RSV-host interactions; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "19" "0" "1.026" "0.861" "0.950" "0.885" "0.784" "0.984" "0.612" "0.923" "4.760" "56.7" "58.2" "48.8" "53.9" "50.2" "44.5" "55.9" "34.7" "52.4" "270.1" "" "" "" "" "" "" "" "" "" "" "51.2" "44.9" "37.8" "36.3" "41.9" "38.0" "47.4" "25.1" "35.3" "270.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619952528215347024" "False" "High" "IsMasterProtein" "P09326" "CD48 antigen OS=Homo sapiens OX=9606 GN=CD48 PE=1 SV=2" "0.000" "False" "9.838" "11" "3" "5" "3" "243" "27.7" "8.07" "14.21" "3" "stress response" "plasma membrane;other membranes" "" "Pf07686, Pf13895" "962" "ENSG00000117091" "CD48" "hsa:962; P09326; Q5U055; Q8MGR0" "Cell surface interactions at the vascular wall" "Gastric cancer network 2" "2" "0" "0.927" "0.850" "1.018" "0.987" "0.788" "0.980" "1.006" "0.811" "0.615" "757.4" "702.0" "644.1" "770.7" "747.7" "597.1" "742.6" "762.3" "614.6" "466.0" "" "" "" "" "" "" "" "" "" "" "683.7" "541.5" "498.2" "519.0" "623.7" "509.6" "629.9" "551.7" "414.5" "466.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6665456693960719485" "False" "High" "IsMasterProtein" "Q86V88" "Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1" "0.000" "False" "9.831" "17" "3" "4" "3" "176" "20.1" "6.39" "10.85" "3" "" "" "other molecular function" "Pf12689" "145553" "ENSG00000213920; ENSG00000285200" "MDP1" "hsa:145553; Q86V88; Q86Y84; Q8NAD9" "" "" "0" "0" "1.081" "1.029" "1.028" "0.955" "1.050" "0.998" "1.090" "0.974" "0.758" "345.6" "373.5" "355.7" "355.1" "330.2" "362.9" "345.0" "376.8" "336.8" "262.1" "" "" "" "" "" "" "" "" "" "" "312.0" "288.1" "275.1" "239.2" "275.4" "309.7" "292.6" "272.7" "227.2" "262.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5589324606331654897" "False" "High" "IsMasterProtein" "Q6P161" "Large ribosomal subunit protein mL54 OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "0.000" "False" "9.829" "14" "2" "2" "2" "138" "15.8" "9.60" "7.73" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.063" "0.943" "0.936" "1.046" "1.041" "1.005" "1.216" "1.024" "0.658" "240.7" "255.9" "226.9" "225.2" "251.9" "250.7" "242.0" "292.8" "246.4" "158.4" "" "" "" "" "" "" "" "" "" "" "217.3" "197.4" "175.5" "151.7" "210.1" "214.0" "205.3" "211.9" "166.2" "158.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7482733620363159602" "False" "High" "IsMasterProtein" "Q9BVS5" "tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2" "0.000" "False" "9.826" "4" "2" "2" "2" "477" "52.9" "6.62" "7.52" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf08704" "55006" "ENSG00000171103" "TRMT61B" "hsa:55006; Q9BVS5; Q9H0Q9; Q9NWS7" "tRNA modification in the mitochondrion" "" "1" "0" "1.066" "0.999" "0.976" "1.038" "0.916" "1.075" "1.092" "0.966" "0.752" "182.7" "194.8" "182.5" "178.3" "189.7" "167.4" "196.4" "199.6" "176.5" "137.4" "" "" "" "" "" "" "" "" "" "" "164.9" "150.3" "141.2" "120.1" "158.2" "142.9" "166.6" "144.4" "119.0" "137.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159799509992601123" "False" "High" "IsMasterProtein" "Q96FK6" "WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=1 SV=1" "0.000" "False" "9.825" "5" "1" "1" "1" "387" "43.2" "6.13" "5.23" "1" "developmental processes" "" "" "Pf00400" "112840" "ENSG00000140006" "WDR89" "hsa:112840; Q96FK6" "" "" "0" "0" "1.235" "1.327" "1.025" "1.113" "1.318" "1.299" "0.844" "1.233" "0.926" "29.7" "36.6" "39.4" "30.4" "33.0" "39.1" "38.5" "25.0" "36.6" "27.5" "" "" "" "" "" "" "" "" "" "" "26.8" "28.2" "30.4" "20.5" "27.6" "33.4" "32.7" "18.1" "24.7" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6207742459099857160" "False" "High" "IsMasterProtein" "Q9UJ41" "Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3" "0.000" "False" "9.820" "8" "4" "4" "4" "491" "56.9" "7.02" "10.52" "4" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01754, Pf02204, Pf18151" "27342" "ENSG00000154710" "RABGEF1" "B4DZM7; hsa:27342; Q3HKR2; Q3HKR3; Q53FG0; Q9UJ41" "RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs" "16p11.2 distal deletion syndrome" "3" "0" "1.303" "1.130" "1.233" "1.380" "1.363" "1.213" "1.375" "1.326" "1.327" "49.3" "64.3" "55.7" "60.8" "68.1" "67.2" "59.8" "67.8" "65.4" "65.5" "" "" "" "" "" "" "" "" "" "" "44.5" "49.6" "43.1" "40.9" "56.8" "57.4" "50.8" "49.1" "44.1" "65.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115257495252240726" "False" "High" "IsMasterProtein" "P82909" "Alpha-ketoglutarate dehydrogenase component 4 OS=Homo sapiens OX=9606 GN=KGD4 PE=1 SV=2" "0.000" "False" "9.810" "12" "1" "2" "1" "103" "11.5" "9.99" "5.20" "1" "other metabolic processes" "other membranes;mitochondrion" "" "" "92259" "ENSG00000134056; ENSG00000278461" "KGD4" "hsa:92259; P82909; Q9H2H4" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.005" "0.778" "0.997" "1.067" "1.155" "1.024" "0.760" "0.973" "0.684" "18.8" "18.9" "14.6" "18.7" "20.1" "21.7" "19.2" "14.3" "18.3" "12.9" "" "" "" "" "" "" "" "" "" "" "17.0" "14.6" "11.3" "12.6" "16.7" "18.5" "16.3" "10.3" "12.3" "12.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678408440687391789" "False" "High" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "0.000" "False" "9.802" "22" "3" "4" "3" "167" "18.8" "8.95" "13.92" "3" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "1.083" "0.897" "1.115" "1.106" "0.887" "1.131" "1.094" "1.034" "1.026" "345.8" "374.3" "310.1" "385.6" "382.3" "306.7" "391.0" "378.1" "357.5" "354.7" "" "" "" "" "" "" "" "" "" "" "312.1" "288.7" "239.8" "259.6" "318.9" "261.8" "331.6" "273.6" "241.1" "354.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6075912895449175249" "False" "High" "IsMasterProtein" "Q9NTG7" "NAD-dependent protein deacetylase sirtuin-3, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT3 PE=1 SV=2" "0.000" "False" "9.796" "6" "2" "2" "2" "399" "43.5" "8.70" "6.35" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23410" "ENSG00000142082" "SIRT3" "B7Z5U6; hsa:23410; Q9NTG7; Q9Y6E8" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Transcriptional activation of mitochondrial biogenesis; Regulation of FOXO transcriptional activity by acetylation" "Energy metabolism; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "8" "0" "0.916" "0.814" "0.828" "0.926" "0.657" "1.290" "1.034" "0.740" "0.883" "23.1" "21.2" "18.8" "19.1" "21.4" "15.2" "29.8" "23.9" "17.1" "20.4" "" "" "" "" "" "" "" "" "" "" "20.9" "16.3" "14.5" "12.9" "17.9" "13.0" "25.3" "17.3" "11.5" "20.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5915355530920662935" "False" "High" "IsMasterProtein" "Q13637" "Ras-related protein Rab-32 OS=Homo sapiens OX=9606 GN=RAB32 PE=1 SV=3" "0.000" "False" "9.777" "9" "2" "3" "1" "225" "25.0" "6.54" "8.53" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "10981" "ENSG00000118508" "RAB32" "hsa:10981; Q13637" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "" "2" "0" "0.843" "0.903" "0.942" "0.804" "0.996" "0.712" "1.022" "0.901" "0.669" "103.2" "87.1" "93.2" "97.2" "83.0" "102.8" "73.4" "105.5" "93.0" "69.1" "" "" "" "" "" "" "" "" "" "" "93.2" "67.2" "72.1" "65.5" "69.3" "87.7" "62.3" "76.3" "62.7" "69.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5956791852298741945" "False" "High" "IsMasterProtein" "Q9UPY8" "Microtubule-associated protein RP/EB family member 3 OS=Homo sapiens OX=9606 GN=MAPRE3 PE=1 SV=1" "0.000" "False" "9.768" "6" "2" "6" "1" "281" "32.0" "5.54" "17.10" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22924" "ENSG00000084764" "MAPRE3" "B7WPK5; hsa:22924; O00265; Q6FHB0; Q6FI15; Q9BZP7; Q9BZP8; Q9UPY8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3449420204754272229" "False" "High" "IsMasterProtein" "Q9NV56" "MRG/MORF4L-binding protein OS=Homo sapiens OX=9606 GN=MRGBP PE=1 SV=1" "0.000" "False" "9.763" "10" "2" "3" "2" "204" "22.4" "5.83" "8.17" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07904" "55257" "ENSG00000101189" "MRGBP" "A8C4L5; hsa:55257; Q9NV56" "HATs acetylate histones" "" "1" "0" "1.071" "1.074" "1.043" "1.007" "1.080" "1.081" "1.277" "0.998" "0.860" "87.6" "93.8" "94.1" "91.3" "88.2" "94.6" "94.7" "111.8" "87.5" "75.3" "" "" "" "" "" "" "" "" "" "" "79.1" "72.4" "72.8" "61.5" "73.6" "80.8" "80.3" "80.9" "59.0" "75.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8942814265025091180" "False" "High" "IsMasterProtein" "Q86U28" "Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2" "0.000" "False" "9.746" "26" "4" "4" "4" "154" "16.5" "5.25" "10.50" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01521" "122961" "ENSG00000165898" "ISCA2" "A6NFF1; A8K3W3; G3V291; hsa:122961; Q86U28; Q8IYZ0; Q96BB2" "Mitochondrial iron-sulfur cluster biogenesis" "" "1" "0" "0.995" "1.138" "1.162" "1.014" "1.128" "1.107" "1.194" "1.074" "1.119" "105.4" "104.9" "119.9" "122.4" "106.8" "118.8" "116.6" "125.8" "113.2" "117.8" "" "" "" "" "" "" "" "" "" "" "95.1" "80.9" "92.7" "82.4" "89.1" "101.4" "98.9" "91.0" "76.3" "117.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1638288113087067454" "False" "High" "IsMasterProtein" "Q9NQG6" "Mitochondrial dynamics protein MIEF1 OS=Homo sapiens OX=9606 GN=MIEF1 PE=1 SV=1" "0.000" "False" "9.745" "4" "2" "2" "2" "463" "51.3" "7.64" "6.91" "2" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf20266, Pf21297" "54471" "ENSG00000100335" "MIEF1" "hsa:54471; Q7L890; Q9BUI3; Q9NQG6" "" "" "0" "0" "1.148" "1.071" "1.256" "1.126" "1.204" "1.099" "1.021" "1.216" "1.454" "228.0" "261.8" "244.3" "286.3" "256.7" "274.6" "250.6" "232.9" "277.3" "331.5" "" "" "" "" "" "" "" "" "" "" "205.8" "201.9" "188.9" "192.8" "214.1" "234.4" "212.6" "168.5" "187.0" "331.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700049213662343528" "False" "High" "IsMasterProtein" "P06396" "Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1" "0.000" "False" "9.745" "4" "3" "5" "3" "782" "85.6" "6.28" "9.68" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "2934" "ENSG00000148180" "GSN" "A2A418; A8MUD1; A8MYN7; B7Z373; B7Z5V1; F5H1A8; hsa:2934; P06396; Q5T0I2; Q8WVV7" "Neutrophil degranulation; Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Caspase-mediated cleavage of cytoskeletal proteins" "Ebola virus infection in host; Regulation of actin cytoskeleton" "6" "0" "1.022" "1.074" "1.018" "0.913" "0.952" "1.004" "1.086" "1.082" "0.881" "150.0" "153.3" "161.0" "152.6" "137.0" "142.7" "150.6" "162.9" "162.3" "132.2" "" "" "" "" "" "" "" "" "" "" "135.4" "118.3" "124.5" "102.8" "114.3" "121.8" "127.7" "117.9" "109.5" "132.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7842122085258800044" "False" "High" "IsMasterProtein" "Q9BVM4" "Gamma-glutamylaminecyclotransferase OS=Homo sapiens OX=9606 GN=GGACT PE=1 SV=2" "0.000" "False" "9.739" "19" "3" "3" "3" "153" "17.3" "6.87" "9.67" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf06094" "87769" "ENSG00000134864" "GGACT" "B3KTN1; hsa:87769; Q9BT41; Q9BVM4" "" "" "0" "0" "0.959" "1.066" "1.202" "1.082" "0.936" "1.100" "1.133" "1.090" "1.249" "53.7" "51.5" "57.2" "64.5" "58.1" "50.2" "59.0" "60.8" "58.5" "67.0" "" "" "" "" "" "" "" "" "" "" "48.4" "39.7" "44.2" "43.4" "48.4" "42.9" "50.1" "44.0" "39.5" "67.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893850793131937072" "False" "High" "IsMasterProtein" "O95749" "Geranylgeranyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=GGPS1 PE=1 SV=1" "0.000" "False" "9.695" "6" "2" "3" "2" "300" "34.8" "6.14" "9.53" "2" "other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00348" "9453" "ENSG00000152904" "GGPS1" "A8MVQ8; hsa:9453; O95749; Q5T2C8; Q6NW19" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis pathway in hepatocytes" "4" "0" "1.025" "1.173" "0.657" "1.120" "1.275" "0.944" "1.148" "1.183" "0.868" "136.1" "139.5" "159.7" "89.4" "152.4" "173.5" "128.4" "156.3" "160.9" "118.1" "" "" "" "" "" "" "" "" "" "" "122.9" "107.6" "123.5" "60.2" "127.1" "148.1" "108.9" "113.1" "108.6" "118.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3850938661228975130" "False" "High" "IsMasterProtein" "Q9NQ55" "Suppressor of SWI4 1 homolog OS=Homo sapiens OX=9606 GN=PPAN PE=1 SV=1" "0.000" "False" "9.683" "5" "2" "2" "2" "473" "53.2" "10.13" "6.70" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04427" "56342; 692312" "ENSG00000130810" "PPAN" "C9J3F9; hsa:56342; hsa:692312; Q9BW97; Q9H170; Q9NQ55" "" "" "0" "0" "0.912" "1.066" "0.865" "1.067" "1.223" "1.097" "0.854" "1.122" "0.805" "53.3" "48.6" "56.8" "46.1" "56.9" "65.2" "58.5" "45.5" "59.8" "42.9" "" "" "" "" "" "" "" "" "" "" "48.1" "37.5" "44.0" "31.1" "47.4" "55.7" "49.6" "32.9" "40.4" "42.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3668723528538727638" "False" "High" "IsMasterProtein" "Q9UDT6" "CAP-Gly domain-containing linker protein 2 OS=Homo sapiens OX=9606 GN=CLIP2 PE=1 SV=1" "0.000" "False" "9.681" "3" "4" "4" "1" "1046" "115.8" "6.73" "10.47" "4" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302" "7461" "ENSG00000106665" "CLIP2" "hsa:7461; O14527; O43611; Q9UDT6" "" "7q11.23 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "846923677132301137" "False" "High" "IsMasterProtein" "Q9UBS8" "E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens OX=9606 GN=RNF14 PE=1 SV=1" "0.000" "False" "9.671" "8" "2" "2" "2" "474" "53.8" "4.75" "5.86" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01485, Pf05773" "9604" "ENSG00000013561" "RNF14" "A0AV26; A6NMR2; A8MTW5; B3KN72; B7ZLV2; D3DQE4; hsa:9604; O94793; Q6IBV0; Q9UBS8" "Antigen processing: Ubiquitination & Proteasome degradation" "Androgen receptor signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6803105277320929101" "False" "High" "IsMasterProtein" "Q99848" "Probable rRNA-processing protein EBP2 OS=Homo sapiens OX=9606 GN=EBNA1BP2 PE=1 SV=2" "0.000" "False" "9.664" "8" "4" "5" "4" "306" "34.8" "10.10" "14.37" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf05890" "10969" "ENSG00000117395" "EBNA1BP2" "hsa:10969; Q96A66; Q99848" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "1.036" "0.872" "0.911" "0.974" "0.824" "0.901" "0.807" "0.885" "0.610" "171.5" "177.7" "149.6" "156.2" "167.0" "141.4" "154.5" "138.4" "151.8" "104.6" "" "" "" "" "" "" "" "" "" "" "154.8" "137.1" "115.7" "105.2" "139.3" "120.7" "131.1" "100.1" "102.4" "104.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2095194651549531862" "False" "High" "IsMasterProtein" "O95487" "Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2" "0.000" "False" "9.651" "1" "1" "2" "1" "1268" "137.3" "6.67" "4.39" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10427" "ENSG00000138802" "SEC24B" "B7ZKM8; B7ZKN4; hsa:10427; O95487; Q0VG08" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "Sterol regulatory element-binding proteins (SREBP) signaling" "7" "0" "0.756" "0.865" "0.606" "0.603" "0.777" "0.691" "0.662" "0.807" "0.846" "48.9" "37.0" "42.3" "29.6" "29.5" "38.0" "33.8" "32.4" "39.5" "41.4" "" "" "" "" "" "" "" "" "" "" "44.2" "28.6" "32.7" "20.0" "24.6" "32.4" "28.7" "23.4" "26.6" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851327045355939363" "False" "High" "IsMasterProtein" "P16401" "Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3" "0.000" "False" "9.639" "12" "3" "3" "1" "226" "22.6" "10.92" "9.16" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3009" "ENSG00000184357" "H1-5" "hsa:3009; P16401; Q14529; Q3MJ42" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779447610884953183" "False" "High" "IsMasterProtein" "Q9NPD8" "Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens OX=9606 GN=UBE2T PE=1 SV=1" "0.000" "False" "9.614" "19" "4" "4" "4" "197" "22.5" "7.99" "8.92" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00179" "29089" "ENSG00000077152" "UBE2T" "hsa:29089; Q2TU36; Q9NPD8" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Fanconi Anemia Pathway" "Gastric cancer network 2" "3" "0" "1.478" "0.563" "1.286" "1.132" "0.790" "1.309" "1.121" "1.114" "2.307" "11.0" "16.3" "6.2" "14.2" "12.5" "8.7" "14.4" "12.3" "12.3" "25.4" "" "" "" "" "" "" "" "" "" "" "9.9" "12.5" "4.8" "9.5" "10.4" "7.4" "12.2" "8.9" "8.3" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8303897606251246511" "False" "High" "IsMasterProtein" "Q96HW7" "Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2" "0.000" "False" "9.604" "3" "3" "3" "3" "963" "108.1" "6.44" "9.20" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13646, Pf20168" "92105" "ENSG00000149262" "INTS4" "hsa:92105; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q96HW7; Q9BRC0" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "1.147" "0.817" "0.940" "1.063" "1.013" "0.943" "0.996" "0.976" "0.802" "140.4" "161.1" "114.6" "131.9" "149.2" "142.2" "132.4" "139.8" "137.0" "112.6" "" "" "" "" "" "" "" "" "" "" "126.7" "124.2" "88.6" "88.8" "124.4" "121.3" "112.3" "101.2" "92.4" "112.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2567249118239018231" "False" "High" "IsMasterProtein" "Q9C0B5" "Palmitoyltransferase ZDHHC5 OS=Homo sapiens OX=9606 GN=ZDHHC5 PE=1 SV=2" "0.000" "False" "9.584" "3" "2" "3" "2" "715" "77.5" "9.01" "8.59" "2" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01529" "25921" "ENSG00000156599" "ZDHHC5" "hsa:25921; Q2TGF0; Q6ZMF0; Q8TAK8; Q9C0B5; Q9H923; Q9UFI7" "Maturation of spike protein" "" "1" "0" "1.161" "1.182" "1.264" "1.235" "1.435" "1.011" "1.072" "1.166" "0.766" "105.6" "122.6" "124.8" "133.5" "130.4" "151.5" "106.8" "113.2" "123.1" "80.9" "" "" "" "" "" "" "" "" "" "" "95.3" "94.6" "96.5" "89.9" "108.8" "129.3" "90.6" "81.9" "83.0" "80.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3054856418516569750" "False" "High" "IsMasterProtein" "Q8IZ07" "Ankyrin repeat domain-containing protein 13A OS=Homo sapiens OX=9606 GN=ANKRD13A PE=1 SV=3" "0.000" "False" "9.580" "4" "2" "2" "2" "590" "67.6" "5.02" "6.51" "2" "other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11904, Pf12796" "88455" "ENSG00000076513" "ANKRD13A" "hsa:88455; O60736; Q8IZ07" "" "" "0" "0" "1.040" "1.014" "1.270" "1.118" "0.919" "1.211" "1.003" "1.036" "1.235" "116.7" "121.4" "118.4" "148.3" "130.6" "107.3" "141.4" "117.1" "120.9" "144.1" "" "" "" "" "" "" "" "" "" "" "105.4" "93.7" "91.6" "99.9" "108.9" "91.6" "120.0" "84.8" "81.5" "144.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6639760008816947129" "False" "High" "IsMasterProtein" "Q6ZUM4" "Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3" "0.000" "False" "9.575" "5" "5" "7" "5" "889" "98.3" "5.59" "17.90" "5" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00397, Pf00620" "201176" "ENSG00000159314; ENSG00000276836; ENSG00000276907" "ARHGAP27" "A4FU35; A8K3N5; C9JTF3; hsa:201176; Q494U0; Q6NWZ8; Q6ZUM4; Q8WY58" "CDC42 GTPase cycle; RAC1 GTPase cycle" "" "2" "0" "0.924" "1.105" "1.098" "0.891" "0.897" "1.044" "1.163" "0.770" "0.946" "39.6" "36.6" "43.7" "43.4" "35.2" "35.5" "41.3" "46.0" "30.5" "37.4" "" "" "" "" "" "" "" "" "" "" "35.7" "28.2" "33.8" "29.3" "29.4" "30.3" "35.0" "33.3" "20.6" "37.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7506213950327089282" "False" "High" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "0.000" "False" "9.573" "6" "3" "6" "3" "465" "52.8" "6.70" "19.80" "3" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "Protein hydroxylation; HDMs demethylate histones" "" "2" "0" "0.983" "0.845" "0.980" "0.997" "0.913" "0.924" "0.935" "0.910" "1.002" "556.0" "546.6" "469.7" "544.7" "554.2" "507.3" "513.7" "519.8" "505.9" "557.3" "" "" "" "" "" "" "" "" "" "" "501.9" "421.6" "363.3" "366.8" "462.3" "433.0" "435.8" "376.2" "341.2" "557.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1984767701943514611" "False" "High" "IsMasterProtein" "Q9NQS1" "Cell death regulator Aven OS=Homo sapiens OX=9606 GN=AVEN PE=1 SV=1" "0.000" "False" "9.567" "10" "3" "3" "3" "362" "38.5" "4.98" "8.44" "3" "other biological processes" "other membranes;cytosol;other cell component" "" "" "57099" "ENSG00000169857" "AVEN" "hsa:57099; Q9NQS1" "Regulation of the apoptosome activity" "" "2" "0" "1.246" "0.964" "1.052" "1.169" "0.870" "1.185" "1.022" "1.023" "0.975" "60.4" "75.2" "58.2" "63.5" "70.6" "52.5" "71.5" "61.7" "61.8" "58.9" "" "" "" "" "" "" "" "" "" "" "54.5" "58.0" "45.0" "42.8" "58.9" "44.8" "60.7" "44.6" "41.7" "58.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1681644365065118187" "False" "High" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "0.000" "False" "9.556" "7" "2" "2" "2" "390" "42.9" "8.72" "6.13" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; O95510; O95511; Q8IVS2" "Mitochondrial Fatty Acid Beta-Oxidation" "Mitochondrial fatty acid synthesis pathway" "2" "0" "1.276" "1.254" "1.153" "1.248" "1.470" "0.943" "0.983" "1.308" "0.698" "20.6" "26.3" "25.8" "23.8" "25.7" "30.3" "19.4" "20.2" "26.9" "14.4" "" "" "" "" "" "" "" "" "" "" "18.6" "20.3" "20.0" "16.0" "21.4" "25.8" "16.5" "14.6" "18.2" "14.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8469309847663247920" "False" "High" "IsMasterProtein" "Q9UEY8" "Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1" "0.000" "False" "9.555" "6" "4" "5" "4" "706" "79.1" "6.32" "12.84" "4" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "120" "ENSG00000148700" "ADD3" "D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8" "RHOD GTPase cycle; RHOF GTPase cycle; Miscellaneous transport and binding events" "" "3" "0" "0.946" "0.785" "0.900" "0.981" "0.956" "0.869" "0.866" "0.976" "0.706" "67.9" "64.2" "53.3" "61.1" "66.6" "64.9" "59.0" "58.8" "66.3" "47.9" "" "" "" "" "" "" "" "" "" "" "61.3" "49.5" "41.2" "41.1" "55.6" "55.4" "50.1" "42.6" "44.7" "47.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5795774045568999421" "False" "High" "IsMasterProtein" "Q9GZR7" "ATP-dependent RNA helicase DDX24 OS=Homo sapiens OX=9606 GN=DDX24 PE=1 SV=1" "0.000" "False" "9.533" "6" "3" "3" "3" "859" "96.3" "9.06" "7.35" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "57062" "ENSG00000089737; ENSG00000273761" "DDX24" "E7EMJ4; hsa:57062; Q4V9L5; Q9GZR7" "" "" "0" "0" "1.170" "1.056" "1.424" "1.121" "1.074" "1.064" "0.622" "1.387" "0.919" "54.1" "63.3" "57.2" "77.1" "60.7" "58.1" "57.6" "33.7" "75.1" "49.8" "" "" "" "" "" "" "" "" "" "" "48.9" "48.9" "44.2" "51.9" "50.6" "49.6" "48.9" "24.4" "50.6" "49.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3380259188437483549" "False" "High" "IsMasterProtein" "Q9NQ88" "Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1" "0.000" "False" "9.502" "9" "2" "2" "2" "270" "30.0" "7.69" "8.10" "2" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00300" "57103" "ENSG00000078237" "TIGAR" "B2R840; hsa:57103; Q9NQ88" "TP53 Regulates Metabolic Genes" "Metabolic reprogramming in colon cancer; p53 transcriptional gene network" "3" "0" "0.896" "0.736" "0.859" "0.917" "0.752" "0.890" "0.843" "0.688" "1.212" "426.4" "381.8" "313.7" "366.2" "391.0" "320.7" "379.7" "359.5" "293.3" "516.5" "" "" "" "" "" "" "" "" "" "" "384.9" "294.5" "242.7" "246.6" "326.1" "273.7" "322.1" "260.2" "197.8" "516.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4229859227879041997" "False" "High" "IsMasterProtein" "P16278" "Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2" "0.000" "False" "9.490" "4" "2" "3" "2" "677" "76.0" "6.57" "8.68" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01301, Pf21317, Pf21467" "2720" "ENSG00000170266" "GLB1" "B2R7H8; B7Z6B0; hsa:2720; P16278; P16279" "Neutrophil degranulation; HS-GAG degradation; Sialic acid metabolism; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective NEU1 causes sialidosis; MPS IV - Morquio syndrome B" "Ectoderm differentiation; Degradation pathway of sphingolipids, including diseases; Ciliary landscape; Glycosaminoglycan degradation; Sphingolipid metabolism in senescence" "12" "0" "1.115" "0.932" "1.025" "0.982" "1.345" "1.113" "0.871" "1.360" "0.831" "29.5" "32.9" "27.5" "30.2" "28.9" "39.6" "32.8" "25.7" "40.1" "24.5" "" "" "" "" "" "" "" "" "" "" "26.6" "25.3" "21.2" "20.3" "24.1" "33.8" "27.8" "18.6" "27.0" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3328900627537449382" "False" "High" "IsMasterProtein" "Q03111" "Protein ENL OS=Homo sapiens OX=9606 GN=MLLT1 PE=1 SV=2" "0.000" "False" "9.490" "4" "2" "2" "2" "559" "62.0" "8.59" "6.43" "2" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf03366, Pf17793" "4298" "ENSG00000130382" "MLLT1" "hsa:4298; Q03111; Q14768" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "0.897" "0.969" "0.815" "1.027" "0.930" "0.864" "1.157" "0.984" "1.259" "105.5" "94.6" "102.2" "86.0" "108.3" "98.1" "91.1" "122.0" "103.8" "132.8" "" "" "" "" "" "" "" "" "" "" "95.2" "73.0" "79.1" "57.9" "90.4" "83.7" "77.3" "88.3" "70.0" "132.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8597337933688242360" "False" "High" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3B PE=1 SV=2" "0.000" "False" "9.489" "24" "4" "18" "1" "136" "15.3" "11.27" "58.82" "4" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Amyloid fiber formation; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation" "36" "3" "1.120" "1.226" "1.210" "1.277" "1.350" "1.189" "1.085" "1.452" "1.097" "621.5" "696.2" "762.1" "751.9" "793.8" "838.9" "739.2" "674.4" "902.2" "681.6" "" "" "" "" "" "" "" "" "" "" "561.0" "537.0" "589.4" "506.3" "662.2" "716.0" "627.1" "488.1" "608.5" "681.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1907773996049463670" "False" "High" "IsMasterProtein" "O43504" "Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1" "0.000" "False" "9.478" "22" "1" "1" "1" "91" "9.6" "4.87" "5.77" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf16672" "10542" "ENSG00000134248" "LAMTOR5" "A0A0C4DGV4; hsa:10542; O43504; Q6IBD8" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "" "7" "0" "1.318" "0.881" "1.233" "1.195" "1.337" "0.881" "0.877" "1.245" "0.964" "34.8" "45.9" "30.7" "42.9" "41.6" "46.6" "30.7" "30.5" "43.3" "33.6" "" "" "" "" "" "" "" "" "" "" "31.4" "35.4" "23.7" "28.9" "34.7" "39.7" "26.0" "22.1" "29.2" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3983028009750613022" "False" "High" "IsMasterProtein" "Q8N122" "Regulatory-associated protein of mTOR OS=Homo sapiens OX=9606 GN=RPTOR PE=1 SV=1" "0.000" "False" "9.477" "3" "4" "4" "4" "1335" "148.9" "6.89" "10.90" "4" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf02985, Pf14538" "57521" "ENSG00000141564" "RPTOR" "B2RN36; C6KEF2; F5H7J5; hsa:57521; Q8N122; Q8N4V9; Q8TB32; Q9P2P3" "TP53 Regulates Metabolic Genes; mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "AMP-activated protein kinase signaling; Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; CAMKK2 pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "34" "0" "1.044" "0.890" "1.046" "1.029" "0.788" "0.938" "1.009" "0.899" "1.453" "201.6" "210.5" "179.6" "210.8" "207.4" "158.8" "189.1" "203.5" "181.2" "293.0" "" "" "" "" "" "" "" "" "" "" "182.0" "162.4" "138.9" "142.0" "173.0" "135.6" "160.4" "147.3" "122.2" "293.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4904792924861238037" "False" "High" "IsMasterProtein" "Q9Y5J6" "Mitochondrial import inner membrane translocase subunit Tim10 B OS=Homo sapiens OX=9606 GN=TIMM10B PE=1 SV=1" "0.000" "False" "9.476" "33" "2" "2" "2" "103" "11.6" "7.43" "6.44" "2" "cell adhesion;cell organization and biogenesis;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26515" "ENSG00000132286" "TIMM10B" "hsa:26515; Q96FF3; Q9Y5J6" "Mitochondrial protein import" "" "1" "0" "1.005" "0.859" "1.045" "0.994" "0.703" "1.168" "1.040" "0.851" "0.653" "55.3" "55.6" "47.5" "57.8" "55.0" "38.9" "64.6" "57.5" "47.1" "36.1" "" "" "" "" "" "" "" "" "" "" "49.9" "42.9" "36.7" "38.9" "45.9" "33.2" "54.8" "41.6" "31.8" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621637110793391590" "False" "High" "IsMasterProtein" "Q9BV79" "Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2" "0.000" "False" "9.464" "6" "2" "2" "2" "373" "40.4" "8.76" "6.95" "2" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00107, Pf08240" "51102" "ENSG00000116353" "MECR" "B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9BV79; Q9Y373" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" "Fatty acid biosynthesis; Mitochondrial fatty acid synthesis pathway" "3" "0" "1.006" "1.054" "1.031" "1.037" "1.016" "1.006" "0.994" "1.054" "0.825" "160.6" "161.5" "169.3" "165.6" "166.5" "163.1" "161.5" "159.7" "169.2" "132.5" "" "" "" "" "" "" "" "" "" "" "145.0" "124.6" "130.9" "111.5" "138.9" "139.2" "137.0" "115.6" "114.1" "132.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2471884395781023228" "False" "High" "IsMasterProtein" "Q9Y5X2" "Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1" "0.000" "False" "9.448" "4" "2" "2" "2" "465" "52.5" "7.39" "5.73" "2" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf19566" "29886" "ENSG00000106266" "SNX8" "A4D207; hsa:29886; Q96I67; Q9Y5X2" "" "" "0" "0" "1.064" "0.953" "0.926" "1.034" "0.906" "1.002" "1.011" "1.021" "0.714" "84.5" "89.9" "80.5" "78.3" "87.4" "76.6" "84.7" "85.4" "86.2" "60.3" "" "" "" "" "" "" "" "" "" "" "76.3" "69.3" "62.3" "52.7" "72.9" "65.3" "71.9" "61.8" "58.2" "60.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049442156646566229" "False" "High" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "0.000" "False" "9.445" "10" "4" "5" "4" "313" "35.1" "7.69" "13.55" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "1.068" "1.076" "1.129" "1.041" "1.144" "1.009" "0.972" "1.193" "0.920" "266.2" "284.2" "286.3" "300.7" "277.1" "304.7" "268.8" "258.7" "317.5" "245.0" "" "" "" "" "" "" "" "" "" "" "240.3" "219.2" "221.5" "202.5" "231.2" "260.0" "228.0" "187.2" "214.2" "245.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544389028450092522" "False" "High" "IsMasterProtein" "P04921" "Glycophorin-C OS=Homo sapiens OX=9606 GN=GYPC PE=1 SV=1" "0.000" "False" "9.432" "20" "1" "1" "1" "128" "13.8" "4.84" "4.42" "1" "" "plasma membrane;other membranes;cytoskeleton" "" "" "2995" "ENSG00000136732" "GYPC" "B2R522; P04921; Q53SV9; Q92642" "Cell surface interactions at the vascular wall" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723353511819689268" "False" "High" "IsMasterProtein" "Q92947" "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" "0.000" "False" "9.429" "9" "3" "4" "3" "438" "48.1" "8.06" "11.41" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "2639" "ENSG00000105607" "GCDH" "A8K2Z2; O14719; Q92947" "Lysine catabolism" "Fatty acid beta-oxidation; Tryptophan metabolism" "3" "0" "0.954" "0.794" "0.906" "0.969" "0.760" "1.049" "1.172" "0.841" "0.618" "274.9" "262.3" "218.3" "249.1" "266.4" "209.0" "288.3" "322.2" "231.3" "169.8" "" "" "" "" "" "" "" "" "" "" "248.1" "202.3" "168.8" "167.7" "222.2" "178.4" "244.5" "233.2" "156.0" "169.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444524107574200916" "False" "High" "IsMasterProtein" "Q9UH73" "Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2" "0.000" "False" "9.419" "4" "3" "3" "2" "591" "64.4" "8.76" "9.21" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "1879" "ENSG00000164330" "EBF1" "hsa:1879; Q8IW11; Q9UH73" "Transcriptional regulation of white adipocyte differentiation; Expression and translocation of olfactory receptors" "Adipogenesis; Prion disease pathway; White fat cell differentiation" "5" "0" "0.880" "0.927" "1.019" "0.930" "0.886" "1.102" "0.817" "1.013" "1.668" "75.6" "66.5" "70.1" "77.1" "70.3" "67.0" "83.3" "61.7" "76.6" "126.1" "" "" "" "" "" "" "" "" "" "" "68.3" "51.3" "54.2" "51.9" "58.7" "57.2" "70.7" "44.7" "51.7" "126.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4607067536077994881" "False" "High" "IsMasterProtein" "Q9Y6H1" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CHCHD2 PE=1 SV=1" "0.000" "False" "9.410" "15" "2" "2" "2" "151" "15.5" "9.22" "6.35" "2" "cell organization and biogenesis;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf06747" "51142" "ENSG00000106153" "CHCHD2" "hsa:51142; Q498C3; Q6NZ50; Q9Y6H1" "Mitochondrial protein degradation; Mitochondrial protein import" "Genetic causes of porto-sinusoidal vascular disease" "3" "0" "1.021" "0.890" "0.946" "0.898" "0.866" "1.001" "1.226" "0.868" "0.942" "86.7" "88.5" "77.2" "82.0" "77.9" "75.1" "86.7" "106.3" "75.2" "81.7" "" "" "" "" "" "" "" "" "" "" "78.3" "68.3" "59.7" "55.2" "65.0" "64.1" "73.6" "76.9" "50.7" "81.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201911436176215" "False" "High" "IsMasterProtein" "Q13952" "Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3" "0.000" "False" "9.405" "6" "3" "3" "3" "458" "50.3" "6.10" "9.53" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "4802" "ENSG00000066136" "NFYC" "B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "" "5" "0" "1.009" "1.015" "0.986" "1.079" "1.006" "1.060" "1.043" "0.978" "0.897" "224.5" "226.5" "227.9" "221.5" "242.4" "225.9" "238.1" "234.2" "219.5" "201.4" "" "" "" "" "" "" "" "" "" "" "202.7" "174.7" "176.2" "149.1" "202.2" "192.8" "202.0" "169.5" "148.1" "201.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833705581656825044" "False" "High" "IsMasterProtein" "Q96RT1" "Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2" "0.000" "False" "9.404" "2" "2" "2" "2" "1412" "158.2" "5.50" "7.85" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00595, Pf13855" "55914" "ENSG00000112851" "ERBIN" "A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8; hsa:55914; Q1RMD0; Q86W38; Q96RT1; Q9NR18; Q9NW48; Q9ULJ5" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "Nucleotide-binding oligomerization domain (NOD) pathway; Nod-like receptor (NLR) signaling pathway; Pathways affected in adenoid cystic carcinoma" "26" "0" "0.945" "1.102" "1.097" "1.117" "1.061" "0.933" "1.003" "1.144" "1.189" "130.2" "123.1" "143.5" "142.7" "145.5" "138.1" "121.5" "130.6" "148.9" "154.8" "" "" "" "" "" "" "" "" "" "" "117.5" "94.9" "111.0" "96.1" "121.3" "117.9" "103.0" "94.5" "100.4" "154.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5017693853216972141" "False" "High" "IsMasterProtein" "Q969S3" "Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "0.000" "False" "9.394" "5" "3" "3" "3" "477" "54.2" "6.15" "9.49" "3" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "0.836" "1.595" "0.953" "0.915" "1.596" "1.033" "1.017" "1.526" "0.636" "251.0" "209.9" "400.2" "239.3" "229.6" "400.5" "259.3" "255.2" "383.0" "159.5" "" "" "" "" "" "" "" "" "" "" "226.5" "161.9" "309.5" "161.1" "191.5" "341.8" "219.9" "184.7" "258.3" "159.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-631503824976752333" "False" "High" "IsMasterProtein" "Q9BYD2" "Large ribosomal subunit protein bL9m OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2" "0.000" "False" "9.365" "13" "3" "3" "3" "267" "30.2" "10.08" "8.32" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01281" "65005" "ENSG00000143436" "MRPL9" "B2RD99; hsa:65005; Q5SZR2; Q9BSW8; Q9BYD2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.056" "0.738" "1.249" "1.004" "0.601" "0.930" "0.926" "0.803" "1.070" "58.3" "61.6" "43.1" "72.9" "58.6" "35.1" "54.3" "54.0" "46.8" "62.4" "" "" "" "" "" "" "" "" "" "" "52.7" "47.5" "33.3" "49.1" "48.9" "29.9" "46.0" "39.1" "31.6" "62.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1553540605597619179" "False" "High" "IsMasterProtein" "P51965" "Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1" "0.000" "False" "9.363" "13" "2" "2" "1" "193" "21.4" "8.53" "6.14" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7324" "ENSG00000170142" "UBE2E1" "B2RBX4; C9J8K2; hsa:7324; K4DI90; P51965" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome" "23" "0" "1.239" "1.825" "1.054" "0.929" "1.663" "1.070" "1.405" "1.021" "2.968" "11.7" "14.4" "21.3" "12.3" "10.8" "19.4" "12.5" "16.4" "11.9" "34.6" "" "" "" "" "" "" "" "" "" "" "10.5" "11.1" "16.5" "8.3" "9.0" "16.5" "10.6" "11.9" "8.0" "34.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7698628990297234698" "False" "High" "IsMasterProtein" "Q9Y3D3" "Small ribosomal subunit protein bS16m OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" "0.000" "False" "9.359" "21" "3" "3" "3" "137" "15.3" "9.50" "5.82" "3" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00886" "51021" "ENSG00000182180" "MRPS16" "B4E032; hsa:51021; Q96Q60; Q9Y3D3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.021" "0.783" "0.929" "1.034" "0.800" "0.925" "0.818" "0.857" "1.261" "100.1" "102.3" "78.4" "93.0" "103.5" "80.1" "92.7" "81.9" "85.8" "126.3" "" "" "" "" "" "" "" "" "" "" "90.4" "78.9" "60.6" "62.6" "86.3" "68.4" "78.6" "59.3" "57.9" "126.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8192519440703409270" "False" "High" "IsMasterProtein" "Q8NB37" "Glutamine amidotransferase-like class 1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATD1 PE=1 SV=1" "0.000" "False" "9.337" "9" "1" "1" "1" "220" "23.3" "6.61" "5.53" "1" "other metabolic processes" "other cell component" "other molecular function" "" "347862" "ENSG00000177225" "GATD1" "B7ZKW5; hsa:347862; Q2NL76; Q6ZQY0; Q8NAE0; Q8NB37" "" "" "0" "0" "1.191" "0.863" "1.043" "1.175" "0.992" "1.090" "0.993" "1.052" "0.814" "42.3" "50.3" "36.5" "44.1" "49.7" "41.9" "46.1" "42.0" "44.5" "34.4" "" "" "" "" "" "" "" "" "" "" "38.2" "38.8" "28.2" "29.7" "41.4" "35.8" "39.1" "30.4" "30.0" "34.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1411414456407117859" "False" "High" "IsMasterProtein" "Q7Z6K3" "Protein prenyltransferase alpha subunit repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PTAR1 PE=1 SV=2" "0.000" "False" "9.326" "3" "1" "1" "1" "402" "46.4" "6.99" "4.66" "1" "" "other cell component" "other molecular function" "Pf01239" "375743" "ENSG00000188647" "PTAR1" "hsa:375743; Q5T7V5; Q5T7V6; Q7Z6K3" "" "" "0" "0" "1.165" "0.724" "0.836" "1.081" "0.760" "1.231" "0.925" "0.948" "0.821" "57.8" "67.3" "41.8" "48.3" "62.4" "43.9" "71.1" "53.4" "54.7" "47.5" "" "" "" "" "" "" "" "" "" "" "52.1" "51.9" "32.3" "32.5" "52.1" "37.5" "60.3" "38.7" "36.9" "47.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5412542927183305238" "False" "High" "IsMasterProtein" "P17535" "Transcription factor JunD OS=Homo sapiens OX=9606 GN=JUND PE=1 SV=3" "0.000" "False" "9.294" "6" "2" "3" "1" "347" "35.2" "7.37" "9.90" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3727" "ENSG00000130522" "JUND" "hsa:3727; P17535; Q53EK9" "NGF-stimulated transcription; Estrogen-dependent gene expression" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; Angiotensin II receptor type 1 pathway; Hypertrophy model; 10q11.21q11.23 copy number variation syndrome; Osteoarthritic chondrocyte hypertrophy" "14" "0" "0.737" "0.810" "1.114" "0.901" "0.819" "1.028" "0.862" "1.013" "0.668" "37.1" "27.4" "30.1" "41.4" "33.5" "30.4" "38.2" "32.0" "37.6" "24.8" "" "" "" "" "" "" "" "" "" "" "33.5" "21.1" "23.3" "27.9" "27.9" "25.9" "32.4" "23.2" "25.4" "24.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5487682516941207466" "False" "High" "IsMasterProtein" "P98171" "Rho GTPase-activating protein 4 OS=Homo sapiens OX=9606 GN=ARHGAP4 PE=1 SV=2" "0.000" "False" "9.279" "3" "3" "3" "3" "946" "105.0" "6.34" "8.12" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00611, Pf00620, Pf14604" "393" "ENSG00000089820" "ARHGAP4" "hsa:393; P98171; Q14144; Q86UY3" "RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "Clock-controlled autophagy in bone metabolism" "4" "0" "0.978" "0.999" "0.904" "1.173" "0.866" "0.930" "0.648" "0.994" "7.626" "100.6" "98.4" "100.5" "91.0" "118.0" "87.2" "93.6" "65.2" "100.1" "767.3" "" "" "" "" "" "" "" "" "" "" "90.8" "75.9" "77.8" "61.3" "98.4" "74.4" "79.4" "47.2" "67.5" "767.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165152486354207968" "False" "High" "IsMasterProtein" "O75037" "Kinesin-like protein KIF21B OS=Homo sapiens OX=9606 GN=KIF21B PE=1 SV=2" "0.000" "False" "9.261" "2" "2" "3" "1" "1637" "182.5" "7.08" "7.05" "2" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00400" "23046" "ENSG00000116852" "KIF21B" "B2RP62; B7ZMI0; hsa:23046; O75037; Q5T4J3" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2858860997982508935" "False" "High" "IsMasterProtein" "Q99757" "Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2" "0.000" "False" "9.261" "6" "1" "3" "1" "166" "18.4" "8.29" "8.07" "1" "stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00085" "25828" "ENSG00000100348" "TXN2" "hsa:25828; Q5JZA0; Q6FH60; Q99757; Q9UH29" "Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine" "Oxidative stress response" "3" "0" "0.872" "1.094" "0.941" "0.917" "1.203" "1.123" "0.977" "1.172" "0.608" "101.1" "88.2" "110.7" "95.2" "92.7" "121.7" "113.6" "98.8" "118.6" "61.5" "" "" "" "" "" "" "" "" "" "" "91.3" "68.0" "85.6" "64.1" "77.4" "103.9" "96.3" "71.5" "80.0" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312562393160644927" "False" "High" "IsMasterProtein" "Q8WV22" "Non-structural maintenance of chromosomes element 1 homolog OS=Homo sapiens OX=9606 GN=NSMCE1 PE=1 SV=5" "0.000" "False" "9.259" "13" "4" "4" "4" "266" "30.8" "7.47" "11.73" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07574, Pf08746" "197370" "ENSG00000169189" "NSMCE1" "D3DWF6; hsa:197370; Q8WV22; Q9P045; Q9P049" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "0.913" "0.988" "0.899" "1.030" "0.858" "0.856" "0.935" "0.953" "1.074" "80.1" "73.1" "79.2" "72.1" "82.5" "68.8" "68.6" "75.0" "76.4" "86.1" "" "" "" "" "" "" "" "" "" "" "72.3" "56.4" "61.2" "48.5" "68.8" "58.7" "58.2" "54.3" "51.5" "86.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2546736599525709996" "False" "High" "IsMasterProtein" "Q8N1G2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1" "0.000" "False" "9.251" "2" "2" "3" "2" "835" "95.3" "7.05" "10.27" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf01728" "23070" "ENSG00000137200" "CMTR1" "A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9" "" "" "0" "0" "0.988" "0.740" "0.956" "1.032" "0.727" "1.037" "0.955" "0.768" "1.081" "307.5" "303.7" "227.6" "293.9" "317.2" "223.5" "318.7" "293.6" "236.1" "332.3" "" "" "" "" "" "" "" "" "" "" "277.5" "234.3" "176.1" "197.9" "264.6" "190.8" "270.3" "212.5" "159.2" "332.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653368877228174187" "False" "High" "IsMasterProtein" "Q9NRX2" "Large ribosomal subunit protein bL17m OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "0.000" "False" "9.243" "14" "3" "3" "3" "175" "20.0" "10.11" "7.42" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.005" "0.860" "0.900" "1.174" "0.832" "0.916" "1.070" "0.932" "1.127" "142.6" "143.3" "122.6" "128.3" "167.5" "118.6" "130.7" "152.7" "132.9" "160.7" "" "" "" "" "" "" "" "" "" "" "128.8" "110.6" "94.9" "86.4" "139.7" "101.2" "110.9" "110.5" "89.7" "160.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1616595542625436951" "False" "High" "IsMasterProtein" "Q96LR5" "Ubiquitin-conjugating enzyme E2 E2 OS=Homo sapiens OX=9606 GN=UBE2E2 PE=1 SV=1" "0.000" "False" "9.234" "17" "3" "6" "2" "201" "22.2" "7.71" "15.28" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00179" "7325" "ENSG00000182247" "UBE2E2" "hsa:7325; Q96LR5" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "1" "0.957" "0.923" "1.026" "0.979" "0.843" "0.966" "0.979" "0.921" "1.613" "322.6" "308.6" "297.7" "331.0" "315.7" "271.8" "311.5" "315.7" "297.1" "520.3" "" "" "" "" "" "" "" "" "" "" "291.2" "238.0" "230.2" "222.9" "263.3" "232.0" "264.2" "228.4" "200.4" "520.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530095289376032453" "False" "High" "IsMasterProtein" "Q9HBH1" "Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1" "0.000" "False" "9.219" "11" "3" "6" "3" "243" "27.0" "9.16" "16.61" "3" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01327" "64146" "ENSG00000258429" "PDF" "hsa:64146; Q8WUN6; Q9HBH1" "" "" "0" "0" "1.015" "1.045" "1.131" "0.970" "1.014" "1.026" "1.064" "1.197" "0.673" "116.2" "118.0" "121.5" "131.4" "112.7" "117.8" "119.2" "123.6" "139.1" "78.2" "" "" "" "" "" "" "" "" "" "" "104.9" "91.0" "94.0" "88.5" "94.0" "100.6" "101.1" "89.5" "93.8" "78.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400843138587659979" "False" "High" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "0.000" "False" "9.205" "4" "3" "3" "3" "930" "103.5" "5.97" "9.36" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "" "2" "0" "0.977" "0.883" "0.914" "0.914" "1.061" "1.037" "0.871" "0.949" "1.095" "73.5" "71.8" "64.9" "67.2" "67.2" "78.0" "76.3" "64.0" "69.8" "80.5" "" "" "" "" "" "" "" "" "" "" "66.4" "55.4" "50.2" "45.2" "56.0" "66.6" "64.7" "46.3" "47.1" "80.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8122664404387137367" "False" "High" "IsMasterProtein" "Q96JP5" "E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1" "0.000" "False" "9.187" "4" "2" "2" "2" "570" "63.4" "7.36" "7.08" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00096" "80829" "ENSG00000186660" "ZFP91" "A6NHC4; A8MSG7; Q86V47; Q96JP4; Q96JP5; Q96QA3" "" "" "0" "0" "0.956" "1.028" "0.894" "1.063" "0.816" "1.154" "1.034" "1.006" "1.040" "86.8" "83.0" "89.3" "77.7" "92.3" "70.9" "100.2" "89.8" "87.4" "90.3" "" "" "" "" "" "" "" "" "" "" "78.4" "64.0" "69.1" "52.3" "77.0" "60.5" "85.0" "65.0" "58.9" "90.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740935786864817136" "False" "High" "IsMasterProtein" "Q9BRX2" "Protein pelota homolog OS=Homo sapiens OX=9606 GN=PELO PE=1 SV=2" "0.000" "False" "9.168" "6" "2" "2" "2" "385" "43.3" "6.34" "5.97" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "Pf03463, Pf03464, Pf03465" "53918" "ENSG00000152684" "PELO" "hsa:53918; Q9BRX2; Q9GZS6; Q9Y306" "" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "1" "0" "1.183" "1.247" "1.031" "0.953" "1.251" "0.990" "0.758" "1.567" "5.435" "59.0" "69.9" "73.6" "60.9" "56.2" "73.8" "58.4" "44.8" "92.5" "320.9" "" "" "" "" "" "" "" "" "" "" "53.3" "53.9" "57.0" "41.0" "46.9" "63.0" "49.6" "32.4" "62.4" "320.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2683396977362819782" "False" "High" "IsMasterProtein" "P17931" "Galectin-3 OS=Homo sapiens OX=9606 GN=LGALS3 PE=1 SV=5" "0.000" "False" "9.157" "13" "4" "6" "4" "250" "26.1" "8.56" "16.98" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00337" "3958" "ENSG00000131981" "LGALS3" "B2RC38; hsa:3958; P17931; Q16005; Q6IBA7; Q96J47" "Neutrophil degranulation; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; Advanced glycosylation endproduct receptor signaling; RUNX2 regulates genes involved in differentiation of myeloid cells" "AGE/RAGE pathway; Spinal cord injury; 2q13 copy number variation syndrome; Immune infiltration in pancreatic cancer" "8" "0" "1.062" "1.094" "1.099" "1.074" "1.132" "1.013" "0.961" "1.121" "0.906" "333.1" "353.7" "364.3" "366.1" "357.7" "377.0" "337.3" "320.1" "373.3" "301.9" "" "" "" "" "" "" "" "" "" "" "300.6" "272.8" "281.8" "246.5" "298.4" "321.8" "286.2" "231.7" "251.8" "301.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6761178778762072522" "False" "High" "IsMasterProtein" "P29460" "Interleukin-12 subunit beta OS=Homo sapiens OX=9606 GN=IL12B PE=1 SV=1" "0.000" "False" "9.150" "6" "1" "1" "1" "328" "37.1" "5.74" "4.99" "1" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf10420" "3593" "ENSG00000113302" "IL12B" "hsa:3593; P29460" "Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interleukin-12 signaling; Interleukin-23 signaling" "Allograft rejection; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Lung fibrosis; Development and heterogeneity of the ILC family; Fibrin complement receptor 3 signaling pathway; Acute viral myocarditis; Resistin as a regulator of inflammation; Selective expression of chemokine receptors during T-cell polarization; Measles virus infection; IL-18 signaling pathway; Neuroinflammation and glutamatergic signaling; Overview of proinflammatory and profibrotic mediators; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; Toll-like receptor signaling pathway" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8334369527451810461" "False" "High" "IsMasterProtein" "Q8NF64" "Zinc finger MIZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZMIZ2 PE=1 SV=2" "0.000" "False" "9.124" "2" "2" "4" "1" "920" "96.5" "7.12" "11.31" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02891" "83637" "ENSG00000122515" "ZMIZ2" "A4D2K7; D3DVL1; hsa:83637; O94790; Q0VGB4; Q659A8; Q6JKL5; Q8NF64; Q8WTX8; Q96Q01; Q9BQH7" "" "" "0" "0" "0.872" "0.969" "0.970" "1.045" "0.961" "1.013" "1.103" "0.879" "0.851" "88.1" "76.9" "85.4" "85.5" "92.1" "84.7" "89.3" "97.2" "77.4" "75.0" "" "" "" "" "" "" "" "" "" "" "79.6" "59.3" "66.1" "57.6" "76.9" "72.3" "75.7" "70.4" "52.2" "75.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014101916445181907" "False" "High" "IsMasterProtein" "Q6BDS2" "Bridge-like lipid transfer protein family member 3A OS=Homo sapiens OX=9606 GN=BLTP3A PE=1 SV=1" "0.000" "False" "9.123" "2" "2" "2" "2" "1440" "159.4" "6.14" "5.86" "2" "" "other cytoplasmic organelle" "other molecular function" "Pf12624" "54887" "ENSG00000065060" "BLTP3A" "hsa:54887; Q6BDS2; Q9NXE0" "" "" "0" "0" "0.986" "0.872" "0.942" "0.978" "0.811" "0.959" "1.024" "0.929" "0.898" "207.5" "204.6" "181.0" "195.5" "202.9" "168.2" "198.9" "212.4" "192.7" "186.2" "" "" "" "" "" "" "" "" "" "" "187.3" "157.8" "140.0" "131.6" "169.3" "143.5" "168.7" "153.7" "130.0" "186.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611870974223822516" "False" "High" "IsMasterProtein" "Q8NHP8" "Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2" "0.000" "False" "9.122" "5" "3" "3" "3" "589" "65.4" "6.80" "9.59" "3" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf04916" "196463" "ENSG00000151176" "PLBD2" "F5H5E2; hsa:196463; Q8NHP8" "" "" "0" "0" "1.085" "0.975" "1.056" "1.064" "1.139" "0.989" "1.009" "1.119" "0.774" "77.0" "83.5" "75.0" "81.3" "81.9" "87.7" "76.1" "77.7" "86.1" "59.6" "" "" "" "" "" "" "" "" "" "" "69.5" "64.4" "58.0" "54.7" "68.3" "74.8" "64.6" "56.2" "58.1" "59.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-144841769978260211" "False" "High" "IsMasterProtein" "P16671" "Platelet glycoprotein 4 OS=Homo sapiens OX=9606 GN=CD36 PE=1 SV=2" "0.000" "False" "9.114" "7" "3" "3" "3" "472" "53.0" "7.96" "8.38" "3" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf01130" "948" "ENSG00000135218" "CD36" "D9IX66; D9IX67; D9IX68; D9IX69; hsa:948; P16671; Q13966; Q16093; Q8TCV7; Q9BPZ8; Q9BQC2; Q9BZM8; Q9BZN3; Q9BZN4; Q9BZN5" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; ER-Phagosome pathway; Neutrophil degranulation; Platelet degranulation ; Scavenging by Class B Receptors; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Interleukin-4 and Interleukin-13 signaling; Intracellular metabolism of fatty acids regulates insulin secretion; Cross-presentation of particulate exogenous antigens (phagosomes)" "Aryl hydrocarbon receptor pathway; PPAR signaling pathway; IL-18 signaling pathway; Genes controlling nephrogenesis; Fatty acid transporters; Cholesterol metabolism; Enterocyte cholesterol metabolism; Vitamin A and carotenoid metabolism" "22" "0" "1.039" "0.969" "0.955" "0.901" "0.904" "0.933" "1.103" "1.029" "0.658" "202.8" "210.6" "196.5" "193.6" "182.8" "183.3" "189.2" "223.8" "208.7" "133.5" "" "" "" "" "" "" "" "" "" "" "183.1" "162.5" "151.9" "130.4" "152.5" "156.5" "160.5" "161.9" "140.8" "133.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740975055967109676" "False" "High" "IsMasterProtein" "O95926" "Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1" "0.000" "False" "9.107" "11" "2" "2" "2" "243" "28.7" "8.40" "8.53" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf08231" "25949" "ENSG00000117614" "SYF2" "hsa:25949; O95926; Q5TH73" "mRNA Splicing - Major Pathway" "" "1" "0" "1.038" "0.820" "1.122" "1.014" "0.975" "0.983" "1.199" "1.286" "0.823" "58.0" "60.2" "47.6" "65.1" "58.8" "56.6" "57.0" "69.5" "74.6" "47.7" "" "" "" "" "" "" "" "" "" "" "52.4" "46.4" "36.8" "43.8" "49.0" "48.3" "48.4" "50.3" "50.3" "47.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-331948696601358906" "False" "High" "IsMasterProtein" "Q969T7" "7-methylguanosine phosphate-specific 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C3B PE=1 SV=4" "0.000" "False" "9.104" "8" "3" "3" "3" "300" "34.4" "6.38" "9.20" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf05822" "115024" "ENSG00000141698" "NT5C3B" "A8MWB9; C9JKC4; hsa:115024; Q7L3B7; Q969T7" "mRNA decay by 3' to 5' exoribonuclease" "" "1" "0" "0.840" "0.638" "0.932" "0.875" "0.653" "0.847" "0.872" "0.748" "0.954" "167.9" "141.0" "107.1" "156.4" "146.9" "109.7" "142.2" "146.4" "125.6" "160.1" "" "" "" "" "" "" "" "" "" "" "151.5" "108.7" "82.9" "105.3" "122.5" "93.6" "120.6" "106.0" "84.7" "160.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4744508132045603899" "False" "High" "IsMasterProtein" "Q9BZG8" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=3" "0.000" "False" "9.099" "5" "1" "1" "1" "438" "48.1" "7.84" "5.01" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01866" "1801" "ENSG00000108963" "DPH1" "A0A6Q8JGF9; D3DTI3; hsa:1801; Q16439; Q4VBA2; Q9BTW7; Q9BZG8; Q9UCY0" "Synthesis of diphthamide-EEF2" "" "1" "0" "1.122" "1.276" "1.037" "1.104" "1.271" "1.110" "1.304" "1.180" "0.962" "40.8" "45.8" "52.1" "42.4" "45.1" "51.9" "45.3" "53.3" "48.2" "39.3" "" "" "" "" "" "" "" "" "" "" "36.9" "35.4" "40.3" "28.5" "37.6" "44.3" "38.5" "38.5" "32.5" "39.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6773616667088229623" "False" "High" "IsMasterProtein" "Q8N4Q0" "Prostaglandin reductase 3 OS=Homo sapiens OX=9606 GN=PTGR3 PE=1 SV=1" "0.000" "False" "9.097" "8" "3" "4" "3" "377" "40.1" "8.18" "7.91" "3" "other metabolic processes;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf00107, Pf08240" "284273" "ENSG00000180011" "PTGR3" "A8KA15; B4DZ91; hsa:284273; Q8N4Q0" "" "" "0" "0" "1.067" "1.014" "1.095" "1.128" "0.980" "1.108" "1.111" "0.962" "0.905" "257.8" "275.0" "261.3" "282.4" "290.7" "252.7" "285.7" "286.3" "248.1" "233.4" "" "" "" "" "" "" "" "" "" "" "232.7" "212.1" "202.1" "190.2" "242.5" "215.6" "242.3" "207.2" "167.3" "233.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262378899326464303" "False" "High" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "0.000" "False" "9.095" "14" "2" "2" "2" "216" "24.5" "5.34" "5.72" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "Unwinding of DNA" "" "1" "0" "0.844" "0.916" "0.751" "0.788" "0.884" "0.859" "0.992" "0.735" "0.848" "51.3" "43.3" "47.0" "38.5" "40.4" "45.3" "44.0" "50.9" "37.7" "43.5" "" "" "" "" "" "" "" "" "" "" "46.3" "33.4" "36.3" "25.9" "33.7" "38.7" "37.4" "36.8" "25.4" "43.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2915122001344888094" "False" "High" "IsMasterProtein" "Q13136" "Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1" "0.000" "False" "9.087" "3" "3" "3" "3" "1202" "135.7" "6.29" "8.24" "3" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00536, Pf07647" "8500" "ENSG00000131626; ENSG00000288198" "PPFIA1" "A6NLE3; hsa:8500; Q13135; Q13136; Q14567; Q8N4I2" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases" "Cell lineage map for neuronal differentiation" "7" "0" "1.023" "1.429" "1.051" "0.845" "1.302" "0.965" "1.045" "1.252" "1.884" "83.9" "85.9" "119.9" "88.2" "70.9" "109.3" "81.0" "87.7" "105.1" "158.1" "" "" "" "" "" "" "" "" "" "" "75.8" "66.2" "92.8" "59.4" "59.2" "93.3" "68.7" "63.5" "70.9" "158.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4936048942270731480" "False" "High" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "0.000" "False" "9.071" "5" "3" "3" "3" "594" "66.0" "9.19" "9.90" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "1.131" "0.942" "1.087" "1.114" "1.019" "1.063" "1.140" "1.076" "0.809" "104.7" "118.4" "98.7" "113.8" "116.6" "106.6" "111.3" "119.3" "112.7" "84.7" "" "" "" "" "" "" "" "" "" "" "94.5" "91.3" "76.3" "76.6" "97.3" "91.0" "94.4" "86.4" "76.0" "84.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3776455647046576995" "False" "High" "IsMasterProtein" "Q7L3B6" "Hsp90 co-chaperone Cdc37-like 1 OS=Homo sapiens OX=9606 GN=CDC37L1 PE=1 SV=1" "0.000" "False" "9.070" "6" "1" "1" "1" "337" "38.8" "5.34" "5.36" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf08565" "55664" "ENSG00000106993" "CDC37L1" "B1AL70; hsa:55664; Q7L3B6; Q9NWS3; Q9NX16" "Platelet degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7228226931451830335" "False" "High" "IsMasterProtein" "O15084" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5" "0.000" "False" "9.070" "2" "2" "2" "2" "1053" "112.9" "6.25" "6.68" "2" "" "cytosol;nucleus" "" "Pf00023, Pf12796" "23243" "ENSG00000206560" "ANKRD28" "B4DES5; hsa:23243; O15084; Q1WWL4; Q29RW6; Q3B857; Q6ULS0; Q6ZT57" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "" "2" "0" "0.958" "0.773" "1.043" "1.010" "0.676" "0.931" "1.002" "0.841" "0.995" "245.3" "234.9" "189.6" "255.8" "247.7" "165.8" "228.3" "245.7" "206.3" "244.2" "" "" "" "" "" "" "" "" "" "" "221.4" "181.2" "146.6" "172.3" "206.7" "141.5" "193.7" "177.8" "139.2" "244.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563797319587415269" "False" "High" "IsMasterProtein" "P25208" "Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2" "0.000" "False" "9.054" "10" "2" "3" "2" "207" "22.8" "4.59" "7.77" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "4801" "ENSG00000120837" "NFYB" "A8K7B9; hsa:4801; P25208; Q96IY8" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "" "5" "0" "0.974" "1.195" "1.074" "0.976" "0.892" "1.061" "1.016" "0.961" "0.839" "179.7" "175.0" "214.8" "192.9" "175.3" "160.3" "190.6" "182.5" "172.7" "150.8" "" "" "" "" "" "" "" "" "" "" "162.2" "135.0" "166.1" "129.9" "146.2" "136.8" "161.7" "132.1" "116.5" "150.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288043512151873046" "False" "High" "IsMasterProtein" "Q8WU39" "Marginal zone B- and B1-cell-specific protein OS=Homo sapiens OX=9606 GN=MZB1 PE=1 SV=1" "0.000" "False" "9.046" "7" "1" "3" "1" "189" "20.7" "5.57" "6.46" "1" "cell organization and biogenesis;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "Pf11938" "51237" "ENSG00000170476" "MZB1" "D2IYS0; hsa:51237; Q7Z6N2; Q8WU39; Q96RL5; Q9P0T3" "" "" "0" "0" "0.916" "1.240" "1.226" "1.008" "1.157" "1.221" "1.023" "1.237" "0.865" "17.2" "15.7" "21.3" "21.1" "17.3" "19.9" "21.0" "17.6" "21.3" "14.9" "" "" "" "" "" "" "" "" "" "" "15.5" "12.1" "16.5" "14.2" "14.5" "17.0" "17.8" "12.7" "14.3" "14.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3087577180827751856" "False" "High" "IsMasterProtein" "Q15172" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1" "0.000" "False" "9.041" "5" "3" "3" "2" "486" "56.2" "6.71" "7.88" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5525" "ENSG00000066027" "PPP2R5A" "B2R6D2; B7Z7L2; D3DT99; hsa:5525; Q15172; Q2NL72; Q5VVB2; Q8TBI9" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "27" "0" "0.840" "0.764" "0.931" "0.901" "0.659" "0.896" "0.893" "0.840" "1.081" "144.5" "121.4" "110.5" "134.6" "130.2" "95.3" "129.5" "129.0" "121.4" "156.2" "" "" "" "" "" "" "" "" "" "" "130.4" "93.6" "85.4" "90.6" "108.6" "81.3" "109.9" "93.3" "81.9" "156.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5151232376153751801" "False" "High" "IsMasterProtein" "Q9UIM3" "FK506-binding protein-like OS=Homo sapiens OX=9606 GN=FKBPL PE=1 SV=1" "0.000" "False" "9.034" "8" "3" "3" "3" "349" "38.2" "5.50" "8.72" "3" "other biological processes" "non-structural extracellular;cytosol" "" "Pf00515" "63943" "ENSG00000204315; ENSG00000223666; ENSG00000224200; ENSG00000230907" "FKBPL" "A8K5V3; B0UYX8; hsa:63943; Q9H5G3; Q9UIM3" "The role of GTSE1 in G2/M progression after G2 checkpoint" "" "1" "0" "0.969" "0.991" "1.004" "0.976" "0.994" "0.916" "0.970" "0.905" "0.763" "173.5" "168.2" "171.9" "174.2" "169.5" "172.5" "159.0" "168.4" "157.1" "132.5" "" "" "" "" "" "" "" "" "" "" "156.6" "129.7" "133.0" "117.3" "141.4" "147.2" "134.9" "121.9" "105.9" "132.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1299453744240154091" "False" "High" "IsMasterProtein" "Q96EB1" "Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2" "0.000" "False" "9.030" "4" "2" "4" "2" "424" "46.6" "8.51" "12.55" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05625" "26610" "ENSG00000109911" "ELP4" "B4E3W0; E7EPZ6; hsa:26610; Q96EB1; Q9H4E8; Q9NX11" "HATs acetylate histones" "Mesodermal commitment pathway" "2" "0" "0.993" "0.884" "1.041" "0.993" "0.894" "0.976" "1.088" "0.880" "0.876" "310.4" "308.1" "274.3" "323.1" "308.0" "277.6" "302.9" "337.7" "273.1" "271.9" "" "" "" "" "" "" "" "" "" "" "280.2" "237.7" "212.2" "217.6" "257.0" "236.9" "257.0" "244.4" "184.2" "271.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469574299663466694" "False" "High" "IsMasterProtein" "P11233" "Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1" "0.000" "False" "9.021" "10" "2" "2" "2" "206" "23.6" "7.11" "6.53" "2" "cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00071" "5898" "ENSG00000006451" "RALA" "A4D1W3; hsa:5898; P11233" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; p38MAPK events" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "8" "0" "0.737" "0.865" "0.979" "0.873" "0.984" "0.953" "0.938" "0.527" "0.624" "46.1" "34.0" "39.9" "45.1" "40.3" "45.3" "43.9" "43.2" "24.3" "28.8" "" "" "" "" "" "" "" "" "" "" "41.6" "26.2" "30.8" "30.4" "33.6" "38.7" "37.3" "31.3" "16.4" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238397026184103268" "False" "High" "IsMasterProtein" "Q9ULU4" "MYND-type zinc finger-containing chromatin reader ZMYND8 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2" "0.000" "False" "9.007" "3" "2" "2" "2" "1186" "131.6" "7.20" "6.58" "2" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00628, Pf00855, Pf12064" "23613" "ENSG00000101040" "ZMYND8" "B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; hsa:23613; J3KPU3; Q13517; Q2HXV1; Q2HXV2; Q2HXV3; Q2HXV4; Q2HXV7; Q2HXV8; Q2HXV9; Q2HXW0; Q2HXW1; Q2HXW2; Q4JJ94; Q4JJ95; Q5TH09; Q5TH11; Q6MZM1; Q8WXC5; Q9H1F3; Q9H1F4; Q9H1F5; Q9H1L8; Q9H1L9; Q9H2G5; Q9NYN3; Q9UIX6; Q9ULU4" "" "" "0" "0" "1.281" "1.922" "1.089" "1.342" "2.368" "1.196" "0.800" "2.005" "2.912" "24.4" "31.3" "46.9" "26.6" "32.7" "57.8" "29.2" "19.5" "48.9" "71.1" "" "" "" "" "" "" "" "" "" "" "22.0" "24.1" "36.3" "17.9" "27.3" "49.3" "24.7" "14.1" "33.0" "71.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343350754074728938" "False" "High" "IsMasterProtein" "P83881" "Large ribosomal subunit protein eL42 OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2" "0.000" "False" "9.005" "16" "2" "4" "1" "106" "12.4" "10.58" "12.71" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus" "other molecular function" "Pf00935" "6173" "ENSG00000241343" "RPL36A" "hsa:6173; P09896; P10661; P83881; Q08ES5; Q5J9I6" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "1" "0.927" "1.084" "0.946" "1.067" "1.122" "1.140" "1.126" "1.027" "0.420" "279.7" "259.2" "303.1" "264.4" "298.3" "313.8" "318.7" "315.0" "287.1" "117.5" "" "" "" "" "" "" "" "" "" "" "252.5" "199.9" "234.4" "178.1" "248.9" "267.8" "270.4" "228.0" "193.7" "117.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020572113107876671" "False" "High" "IsMasterProtein" "Q13643" "Four and a half LIM domains protein 3 OS=Homo sapiens OX=9606 GN=FHL3 PE=1 SV=4" "0.000" "False" "9.004" "9" "3" "3" "3" "280" "31.2" "6.20" "8.58" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "2275" "ENSG00000183386" "FHL3" "D3DPT6; hsa:2275; Q13643; Q6I9T0; Q9BVA2" "" "" "0" "0" "1.088" "0.760" "1.014" "0.908" "0.907" "0.866" "1.008" "0.825" "0.633" "152.4" "165.8" "115.7" "154.6" "138.3" "138.2" "132.0" "153.6" "125.7" "96.5" "" "" "" "" "" "" "" "" "" "" "137.6" "127.9" "89.5" "104.1" "115.4" "118.0" "112.0" "111.2" "84.8" "96.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5995744781224398015" "False" "High" "IsMasterProtein" "P10746" "Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1" "0.000" "False" "8.975" "13" "3" "3" "3" "265" "28.6" "5.48" "7.81" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf02602" "7390" "ENSG00000188690" "UROS" "B2RC13; D3DRF7; hsa:7390; P10746; Q9H2T1" "Heme biosynthesis" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "3" "0" "0.979" "0.927" "1.079" "1.106" "0.803" "0.840" "1.041" "0.918" "1.000" "103.9" "101.7" "96.3" "112.0" "114.9" "83.4" "87.2" "108.2" "95.4" "103.9" "" "" "" "" "" "" "" "" "" "" "93.8" "78.4" "74.5" "75.5" "95.8" "71.2" "74.0" "78.3" "64.3" "103.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650974207865814862" "False" "High" "IsMasterProtein" "P04818" "Thymidylate synthase OS=Homo sapiens OX=9606 GN=TYMS PE=1 SV=3" "0.000" "False" "8.946" "8" "3" "3" "3" "313" "35.7" "7.01" "8.67" "3" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00303" "7298" "ENSG00000176890" "TYMS" "hsa:7298; P04818; Q8WYK3; Q8WYK4" "Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism" "9" "0" "0.942" "1.114" "0.901" "0.973" "1.005" "0.877" "0.956" "0.950" "2.654" "127.2" "119.9" "141.7" "114.6" "123.7" "127.9" "111.5" "121.7" "120.9" "337.6" "" "" "" "" "" "" "" "" "" "" "114.8" "92.5" "109.6" "77.2" "103.2" "109.2" "94.6" "88.0" "81.5" "337.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4219913778501772025" "False" "High" "IsMasterProtein" "Q96PE7" "Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1" "0.000" "False" "8.932" "16" "3" "4" "3" "176" "18.7" "9.09" "11.10" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf13669" "84693" "ENSG00000124370" "MCEE" "hsa:84693; Q53TP1; Q8WW63; Q96PE7" "Propionyl-CoA catabolism" "Vitamin B12 metabolism" "2" "0" "0.977" "0.869" "1.028" "0.887" "1.039" "1.004" "1.091" "0.898" "0.694" "69.7" "68.1" "60.5" "71.6" "61.8" "72.4" "70.0" "76.0" "62.5" "48.4" "" "" "" "" "" "" "" "" "" "" "62.9" "52.5" "46.8" "48.2" "51.5" "61.8" "59.4" "55.0" "42.2" "48.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1713406968265840354" "False" "High" "IsMasterProtein" "O60825" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Homo sapiens OX=9606 GN=PFKFB2 PE=1 SV=2" "0.000" "False" "8.920" "6" "3" "3" "2" "505" "58.4" "8.38" "8.78" "3" "other metabolic processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5208" "ENSG00000123836" "PFKFB2" "hsa:5208; O60824; O60825; Q5VVQ3; Q5VVQ4; Q9H3P1" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "3" "1" "1.130" "0.798" "1.037" "0.920" "0.814" "0.854" "0.827" "0.898" "0.747" "126.7" "143.2" "101.1" "131.5" "116.6" "103.1" "108.3" "104.8" "113.9" "94.6" "" "" "" "" "" "" "" "" "" "" "114.4" "110.5" "78.2" "88.5" "97.2" "88.0" "91.8" "75.9" "76.8" "94.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3620399161639766887" "False" "High" "IsMasterProtein" "Q99471" "Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2" "0.000" "False" "8.918" "10" "2" "3" "2" "154" "17.3" "6.33" "9.21" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02996" "5204" "ENSG00000123349; ENSG00000291834" "PFDN5" "A8K9A8; hsa:5204; Q54AA8; Q99471; Q9C083; Q9C084" "Prefoldin mediated transfer of substrate to CCT/TriC" "Cellular proteostasis" "2" "0" "0.970" "0.972" "0.985" "0.924" "0.993" "0.995" "1.033" "0.848" "0.630" "360.4" "349.7" "350.3" "354.9" "333.2" "358.1" "358.7" "372.3" "305.6" "227.2" "" "" "" "" "" "" "" "" "" "" "325.4" "269.8" "271.0" "239.0" "277.9" "305.6" "304.3" "269.4" "206.1" "227.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5153140893326454359" "False" "High" "IsMasterProtein" "Q99496" "E3 ubiquitin-protein ligase RING2 OS=Homo sapiens OX=9606 GN=RNF2 PE=1 SV=1" "0.000" "False" "8.904" "8" "2" "3" "2" "336" "37.6" "6.84" "6.55" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf16207" "6045" "ENSG00000121481" "RNF2" "B2RBS7; B3KRH1; Q5TEN1; Q5TEN2; Q99496" "Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465801585106187641" "False" "High" "IsMasterProtein" "P52735" "Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9606 GN=VAV2 PE=1 SV=2" "0.000" "False" "8.904" "3" "3" "3" "3" "878" "101.2" "7.08" "8.68" "3" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00130, Pf00169, Pf00307, Pf00621, Pf07653" "7410" "ENSG00000160293" "VAV2" "A2RUM4; A8MQ12; B6ZDF5; hsa:7410; P52735; Q5SYV3; Q5SYV4; Q5SYV5; Q6N012; Q6PIJ9; Q6Q317" "Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; GPVI-mediated activation cascade; DAP12 signaling; EPH-ephrin mediated repulsion of cells; Signal transduction by L1; Azathioprine ADME; VEGFR2 mediated vascular permeability" "Integrin-mediated cell adhesion; Prolactin signaling pathway; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Focal adhesion; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Ebola virus infection in host; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; GDNF signaling" "34" "0" "1.143" "1.182" "1.294" "1.055" "1.002" "1.123" "0.702" "1.187" "6.865" "35.2" "40.2" "41.6" "45.5" "37.1" "35.3" "39.5" "24.7" "41.8" "241.5" "" "" "" "" "" "" "" "" "" "" "31.8" "31.0" "32.1" "30.6" "31.0" "30.1" "33.5" "17.9" "28.2" "241.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901447341290801043" "False" "High" "IsMasterProtein" "Q66PJ3" "ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=3" "0.000" "False" "8.882" "5" "1" "2" "1" "237" "26.4" "10.86" "5.38" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10500" "51329" "ENSG00000182196" "ARL6IP4" "A4UCR8; B3V0L0; B3V0L1; hsa:51329; Q4F966; Q504R8; Q66PJ3; Q96BI2; Q9NR05; Q9P2R9" "" "" "0" "0" "1.042" "0.785" "0.696" "0.935" "1.004" "1.135" "0.922" "0.846" "0.718" "47.9" "49.9" "37.6" "33.3" "44.8" "48.1" "54.3" "44.2" "40.5" "34.4" "" "" "" "" "" "" "" "" "" "" "43.2" "38.5" "29.1" "22.4" "37.4" "41.0" "46.1" "32.0" "27.3" "34.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-938207872866175487" "False" "High" "IsMasterProtein" "Q00534" "Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1" "0.000" "False" "8.881" "8" "3" "5" "2" "326" "36.9" "6.46" "14.39" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1021" "ENSG00000105810" "CDK6" "A4D1G0; hsa:1021; Q00534" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "30" "0" "1.037" "0.936" "0.975" "0.993" "0.958" "0.877" "0.905" "0.970" "2.286" "175.7" "182.1" "164.5" "171.3" "174.5" "168.3" "154.1" "159.1" "170.4" "401.7" "" "" "" "" "" "" "" "" "" "" "158.6" "140.5" "127.2" "115.4" "145.6" "143.6" "130.7" "115.1" "114.9" "401.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6391839617332390225" "False" "High" "IsMasterProtein" "P07203" "Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4" "0.000" "False" "8.875" "10" "2" "2" "2" "203" "22.1" "6.55" "7.44" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00255" "2876" "ENSG00000233276" "GPX1" "E9PAS1; hsa:2876; P07203; Q7Z5H1; Q9BW12" "Detoxification of Reactive Oxygen Species; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; One-carbon metabolism and related pathways; TYROBP causal network in microglia; Oxidative stress response; Male infertility; p53 transcriptional gene network; Omega-6-fatty acids in senescence" "18" "0" "1.126" "1.001" "1.127" "1.103" "1.099" "1.062" "0.944" "0.932" "0.637" "130.4" "146.9" "130.6" "147.0" "143.8" "143.3" "138.5" "123.2" "121.6" "83.0" "" "" "" "" "" "" "" "" "" "" "117.7" "113.3" "101.0" "99.0" "120.0" "122.3" "117.5" "89.1" "82.0" "83.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9154000995379348407" "False" "High" "IsMasterProtein" "Q16644" "MAP kinase-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPKAPK3 PE=1 SV=1" "0.000" "False" "8.850" "10" "4" "5" "2" "382" "43.0" "7.28" "13.03" "4" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7867" "ENSG00000114738" "MAPKAPK3" "B5BU67; hsa:7867; Q16644" "Oxidative Stress Induced Senescence; VEGFA-VEGFR2 Pathway; p38MAPK events; activated TAK1 mediates p38 MAPK activation" "Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Serotonin HTR1 group and FOS pathway" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5403198551536365946" "False" "High" "IsMasterProtein" "Q14692" "Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens OX=9606 GN=BMS1 PE=1 SV=1" "0.000" "False" "8.850" "2" "3" "3" "3" "1282" "145.7" "6.44" "9.45" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "9790" "ENSG00000165733" "BMS1" "hsa:9790; Q14692; Q5QPT5; Q86XJ9" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.011" "0.773" "0.807" "1.172" "0.690" "1.113" "0.927" "0.927" "0.627" "35.4" "35.8" "27.3" "28.6" "41.5" "24.4" "39.4" "32.8" "32.8" "22.2" "" "" "" "" "" "" "" "" "" "" "31.9" "27.6" "21.1" "19.2" "34.6" "20.8" "33.4" "23.7" "22.1" "22.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518403686067478951" "False" "High" "IsMasterProtein" "O95149" "Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1" "0.000" "False" "8.845" "7" "3" "4" "3" "360" "41.1" "6.64" "12.78" "3" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11538" "10073" "ENSG00000169371" "SNUPN" "A6NE34; A8K0B0; D3DW76; hsa:10073; O95149" "snRNP Assembly" "" "1" "0" "0.897" "0.784" "0.866" "0.926" "0.859" "0.923" "0.841" "0.833" "1.399" "370.2" "332.1" "290.3" "320.4" "342.9" "317.8" "341.8" "311.4" "308.5" "518.0" "" "" "" "" "" "" "" "" "" "" "334.2" "256.1" "224.5" "215.8" "286.0" "271.3" "290.0" "225.4" "208.1" "518.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8852376921802983428" "False" "High" "IsMasterProtein" "Q9UN19" "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide OS=Homo sapiens OX=9606 GN=DAPP1 PE=1 SV=1" "0.000" "False" "8.839" "8" "2" "2" "2" "280" "32.2" "7.80" "7.09" "2" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00017, Pf00169" "27071" "ENSG00000070190" "DAPP1" "hsa:27071; Q8TCK5; Q9UHF2; Q9UN19" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "B cell receptor signaling pathway" "2" "0" "1.129" "1.082" "1.213" "1.318" "1.030" "1.190" "0.947" "1.009" "4.670" "123.4" "139.3" "133.5" "149.7" "162.7" "127.1" "146.9" "116.9" "124.6" "576.4" "" "" "" "" "" "" "" "" "" "" "111.4" "107.4" "103.3" "100.8" "135.7" "108.5" "124.6" "84.6" "84.0" "576.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421989768094974956" "False" "High" "IsMasterProtein" "Q96BM9" "ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1" "0.000" "False" "8.838" "10" "2" "3" "2" "186" "21.4" "7.77" "11.22" "2" "cell cycle OR cell proliferation;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "127829" "ENSG00000143862" "ARL8A" "B3KXD0; hsa:127829; Q96BM9" "Neutrophil degranulation" "" "1" "0" "1.219" "1.055" "1.102" "1.082" "1.022" "1.095" "1.133" "0.934" "0.867" "164.7" "200.9" "173.7" "181.5" "178.2" "168.3" "180.4" "186.6" "153.8" "142.8" "" "" "" "" "" "" "" "" "" "" "148.7" "155.0" "134.4" "122.2" "148.6" "143.6" "153.0" "135.1" "103.7" "142.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8410241835469765050" "False" "High" "IsMasterProtein" "Q9Y2G2" "Caspase recruitment domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CARD8 PE=1 SV=2" "0.000" "False" "8.824" "3" "2" "2" "2" "537" "60.6" "4.84" "7.05" "2" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf13553" "22900" "ENSG00000105483" "CARD8" "B5KVR6; B5KVR8; B7Z496; B7Z4A2; E5RFV9; E9PEM7; G3XAM9; hsa:22900; Q6PGP8; Q96P82; Q9Y2G2" "Regulation of the apoptosome activity" "Nucleotide-binding oligomerization domain (NOD) pathway" "3" "0" "0.972" "1.029" "1.072" "0.961" "0.896" "0.925" "0.934" "0.957" "0.862" "272.5" "264.9" "280.5" "292.1" "261.8" "244.2" "252.0" "254.6" "260.8" "234.9" "" "" "" "" "" "" "" "" "" "" "246.0" "204.4" "217.0" "196.7" "218.4" "208.5" "213.7" "184.3" "175.9" "234.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5805697236743296122" "False" "High" "IsMasterProtein" "Q96QU8" "Exportin-6 OS=Homo sapiens OX=9606 GN=XPO6 PE=1 SV=1" "0.000" "False" "8.813" "3" "4" "4" "4" "1125" "128.8" "6.35" "12.38" "4" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03810, Pf08389" "23214" "ENSG00000169180" "XPO6" "A1L3W4; D3DWF9; hsa:23214; Q2YDX3; Q53G88; Q68G50; Q76N88; Q96CP8; Q96QU8; Q9BT21" "" "" "0" "0" "0.901" "0.815" "0.976" "1.072" "0.900" "0.977" "0.944" "1.015" "1.569" "197.0" "177.6" "160.6" "192.2" "211.1" "177.3" "192.5" "185.9" "199.9" "309.0" "" "" "" "" "" "" "" "" "" "" "177.8" "137.0" "124.2" "129.4" "176.1" "151.3" "163.3" "134.5" "134.8" "309.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3107148339785297628" "False" "High" "IsMasterProtein" "Q12894" "Interferon-related developmental regulator 2 OS=Homo sapiens OX=9606 GN=IFRD2 PE=1 SV=4" "0.000" "False" "8.806" "6" "3" "3" "3" "442" "48.0" "6.84" "8.85" "3" "other biological processes" "" "translation activity;other molecular function" "Pf04836, Pf05004" "7866" "ENSG00000214706" "IFRD2" "A0A0R4J2F6; hsa:7866; Q12894; Q9BVB4; Q9UJ88" "" "" "0" "0" "1.051" "0.760" "0.922" "0.846" "0.709" "0.887" "0.963" "0.883" "0.421" "245.0" "257.4" "186.3" "226.0" "207.3" "173.6" "217.2" "236.0" "216.3" "103.0" "" "" "" "" "" "" "" "" "" "" "221.1" "198.6" "144.1" "152.2" "173.0" "148.2" "184.3" "170.8" "145.9" "103.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8648350258145669710" "False" "High" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "0.000" "False" "8.806" "11" "3" "4" "3" "326" "36.1" "9.17" "10.24" "3" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "HuR (ELAVL1) binds and stabilizes mRNA" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "10" "0" "1.091" "1.089" "0.970" "0.884" "1.070" "0.887" "0.804" "1.435" "1.598" "36.7" "40.1" "40.0" "35.6" "32.5" "39.3" "32.6" "29.5" "52.7" "58.7" "" "" "" "" "" "" "" "" "" "" "33.1" "30.9" "30.9" "24.0" "27.1" "33.5" "27.6" "21.4" "35.5" "58.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1884707447535219714" "False" "High" "IsMasterProtein" "Q9BYM8" "RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=RBCK1 PE=1 SV=2" "0.000" "False" "8.800" "6" "3" "3" "3" "510" "57.5" "5.67" "8.12" "3" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13445" "10616" "ENSG00000125826" "RBCK1" "O95623; Q86SL2; Q96BS3; Q9BYM8; Q9BYM9" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "TAR syndrome" "5" "0" "1.001" "1.015" "1.093" "1.077" "0.795" "1.182" "1.114" "1.126" "0.899" "74.8" "74.9" "75.9" "81.8" "80.5" "59.5" "88.4" "83.3" "84.2" "67.2" "" "" "" "" "" "" "" "" "" "" "67.5" "57.8" "58.7" "55.1" "67.2" "50.8" "75.0" "60.3" "56.8" "67.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "59184659773015562" "False" "High" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "0.000" "False" "8.798" "9" "2" "4" "2" "173" "18.8" "6.68" "9.06" "2" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "XBP1(S) activates chaperone genes" "" "1" "0" "1.064" "1.123" "1.106" "0.987" "1.063" "1.058" "0.994" "1.015" "0.723" "521.3" "554.7" "585.4" "576.5" "514.4" "554.0" "551.6" "518.0" "528.9" "377.2" "" "" "" "" "" "" "" "" "" "" "470.6" "427.9" "452.8" "388.2" "429.1" "472.9" "467.9" "374.9" "356.7" "377.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5626279923656509616" "False" "High" "IsMasterProtein" "P25325" "3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3" "0.000" "False" "8.797" "9" "3" "6" "3" "297" "33.2" "6.60" "17.94" "3" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00581" "4357" "ENSG00000128309" "MPST" "A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9" "Degradation of cysteine and homocysteine" "Trans-sulfuration pathway; Amino acid metabolism" "3" "0" "0.931" "0.905" "1.086" "1.126" "0.879" "1.101" "0.979" "1.019" "1.570" "136.4" "127.0" "123.4" "148.1" "153.6" "119.8" "150.1" "133.5" "139.0" "214.1" "" "" "" "" "" "" "" "" "" "" "123.1" "97.9" "95.4" "99.7" "128.1" "102.3" "127.3" "96.6" "93.8" "214.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3241468308071992901" "False" "High" "IsMasterProtein" "Q8NI08" "Nuclear receptor coactivator 7 OS=Homo sapiens OX=9606 GN=NCOA7 PE=1 SV=2" "0.000" "False" "8.793" "3" "2" "2" "2" "942" "106.1" "5.59" "7.20" "2" "stress response;other biological processes" "nucleus" "other molecular function" "Pf01476, Pf07534" "135112" "ENSG00000111912" "NCOA7" "B2RNS2; B7Z2C4; B9EH71; G8JL91; hsa:135112; Q3LID6; Q4G0V1; Q5TF95; Q6IPQ4; Q6NE83; Q86T89; Q8N1W4; Q8NI08" "" "Aryl hydrocarbon receptor pathway" "1" "0" "1.035" "0.892" "0.747" "1.014" "0.911" "0.826" "1.020" "0.811" "1.042" "88.0" "91.1" "78.5" "65.7" "89.2" "80.1" "72.7" "89.7" "71.4" "91.6" "" "" "" "" "" "" "" "" "" "" "79.4" "70.3" "60.7" "44.3" "74.4" "68.4" "61.6" "64.9" "48.2" "91.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5388836657935240768" "False" "High" "IsMasterProtein" "Q12872" "Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3" "0.000" "False" "8.787" "2" "2" "2" "2" "951" "104.8" "8.05" "6.44" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01805, Pf09750" "6433" "ENSG00000061936" "SFSWAP" "B2RN45; B7ZM97; F5H6B8; hsa:6433; Q12872; Q6PJF7" "" "mRNA processing" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7165899401853608207" "False" "High" "IsMasterProtein" "P04424" "Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4" "0.000" "False" "8.781" "4" "2" "2" "2" "464" "51.6" "6.48" "6.95" "2" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf14698" "435" "ENSG00000126522" "ASL" "E7EMI0; E9PE48; hsa:435; P04424; Q6LDS5; Q96HS2" "Urea cycle" "Alanine and aspartate metabolism" "2" "0" "0.996" "0.887" "0.987" "0.795" "0.996" "0.947" "0.696" "0.875" "1.043" "71.4" "71.1" "63.3" "70.5" "56.8" "71.2" "67.6" "49.7" "62.5" "74.5" "" "" "" "" "" "" "" "" "" "" "64.5" "54.8" "49.0" "47.5" "47.4" "60.7" "57.4" "36.0" "42.1" "74.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4826507384630182713" "False" "High" "IsMasterProtein" "Q96IZ7" "Serine/Arginine-related protein 53 OS=Homo sapiens OX=9606 GN=RSRC1 PE=1 SV=1" "0.000" "False" "8.775" "7" "2" "2" "2" "334" "38.7" "11.08" "5.92" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "" "" "51319" "ENSG00000174891" "RSRC1" "A8K2R9; hsa:51319; Q96IZ7; Q96QK2; Q9NZE5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250154090209623680" "False" "High" "IsMasterProtein" "Q9H2W6" "Large ribosomal subunit protein mL46 OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "0.000" "False" "8.775" "10" "3" "3" "3" "279" "31.7" "7.05" "8.67" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.968" "0.946" "0.995" "0.992" "0.859" "1.110" "1.073" "0.880" "1.065" "263.3" "254.8" "249.0" "262.0" "261.3" "226.2" "292.1" "282.5" "231.6" "280.3" "" "" "" "" "" "" "" "" "" "" "237.7" "196.6" "192.6" "176.4" "218.0" "193.1" "247.8" "204.4" "156.2" "280.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369006210393907159" "False" "High" "IsMasterProtein" "Q16877" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 OS=Homo sapiens OX=9606 GN=PFKFB4 PE=1 SV=6" "0.000" "False" "8.770" "4" "2" "2" "1" "469" "54.0" "6.62" "6.85" "2" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00300, Pf01591" "5210" "ENSG00000114268" "PFKFB4" "hsa:5210; Q16877; Q5S3G5; Q5XLC2; Q64EX5" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling" "3" "0" "1.071" "0.911" "1.038" "0.949" "0.830" "1.000" "1.005" "0.919" "0.882" "116.4" "124.6" "106.0" "120.8" "110.4" "96.6" "116.4" "116.9" "106.9" "102.6" "" "" "" "" "" "" "" "" "" "" "105.0" "96.1" "82.0" "81.3" "92.1" "82.4" "98.7" "84.6" "72.1" "102.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5430220103658382973" "False" "High" "IsMasterProtein" "Q969Q0" "Ribosomal protein eL42-like OS=Homo sapiens OX=9606 GN=RPL36AL PE=1 SV=3" "0.000" "False" "8.759" "16" "2" "3" "1" "106" "12.5" "10.65" "8.59" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus" "other molecular function" "Pf00935" "6166" "ENSG00000165502" "RPL36AL" "hsa:6166; Q3B7A5; Q969Q0" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "" "13" "0" "0.910" "1.079" "0.775" "0.979" "1.009" "0.936" "1.252" "1.012" "0.528" "66.0" "60.1" "71.2" "51.2" "64.6" "66.6" "61.8" "82.6" "66.8" "34.9" "" "" "" "" "" "" "" "" "" "" "59.6" "46.3" "55.1" "34.5" "53.9" "56.8" "52.4" "59.8" "45.0" "34.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5720484629679422275" "False" "High" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "0.000" "False" "8.745" "4" "2" "2" "2" "492" "57.2" "5.92" "6.53" "2" "" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "mRNA Splicing - Major Pathway" "" "1" "0" "0.914" "0.748" "1.015" "1.009" "0.694" "1.058" "0.905" "0.782" "1.857" "199.9" "182.8" "149.6" "202.9" "201.8" "138.7" "211.5" "181.0" "156.4" "371.3" "" "" "" "" "" "" "" "" "" "" "180.5" "141.0" "115.7" "136.6" "168.3" "118.4" "179.4" "131.0" "105.5" "371.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5970441865792546005" "False" "High" "IsMasterProtein" "P04920" "Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4" "0.000" "False" "8.739" "2" "2" "2" "2" "1241" "136.9" "6.29" "5.85" "2" "transport;developmental processes;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00955, Pf07565" "6522" "ENSG00000164889" "SLC4A2" "B2R6T0; B4DIT0; D3DX05; F8W682; hsa:6522; P04920; Q45EY5; Q969L3" "Bicarbonate transporters" "Proximal tubule transport" "2" "0" "0.957" "1.110" "1.130" "1.024" "0.979" "0.900" "1.070" "1.110" "0.756" "41.9" "40.1" "46.5" "47.4" "42.9" "41.1" "37.7" "44.9" "46.6" "31.7" "" "" "" "" "" "" "" "" "" "" "37.8" "30.9" "36.0" "31.9" "35.8" "35.0" "32.0" "32.5" "31.4" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8474719942598486325" "False" "High" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "0.000" "False" "8.738" "4" "3" "4" "3" "563" "65.1" "5.05" "11.45" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "mRNA Splicing - Major Pathway" "" "1" "0" "0.983" "1.050" "1.209" "1.178" "1.080" "1.060" "0.293" "0.840" "17.229" "26.9" "26.5" "28.3" "32.6" "31.7" "29.1" "28.6" "7.9" "22.6" "464.3" "" "" "" "" "" "" "" "" "" "" "24.3" "20.4" "21.9" "21.9" "26.5" "24.8" "24.2" "5.7" "15.3" "464.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271689599031996441" "False" "High" "IsMasterProtein" "Q9H1K1" "Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2" "0.000" "False" "8.721" "14" "3" "3" "3" "167" "18.0" "9.48" "8.08" "3" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01592" "23479" "ENSG00000136003" "ISCU" "hsa:23479; Q6P713; Q99617; Q9H1K1; Q9H1K2" "Maturation of replicase proteins" "Iron-sulfur cluster biogenesis" "2" "0" "0.967" "1.073" "1.246" "1.084" "1.167" "0.965" "1.051" "1.126" "0.653" "199.3" "192.8" "214.0" "248.4" "216.1" "232.6" "192.3" "209.4" "224.4" "130.1" "" "" "" "" "" "" "" "" "" "" "179.9" "148.7" "165.5" "167.3" "180.2" "198.5" "163.1" "151.6" "151.3" "130.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9003669345530149661" "False" "High" "IsMasterProtein" "Q15738" "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=NSDHL PE=1 SV=2" "0.000" "False" "8.714" "9" "3" "3" "3" "373" "41.9" "8.06" "6.25" "3" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01073" "50814" "ENSG00000147383; ENSG00000292192" "NSDHL" "D3DWT6; hsa:50814; O00344; Q15738" "Cholesterol biosynthesis" "Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "7" "0" "0.981" "1.031" "1.064" "1.017" "0.918" "1.017" "0.914" "1.065" "1.062" "98.7" "96.8" "101.8" "105.1" "100.4" "90.6" "100.4" "90.3" "105.1" "104.8" "" "" "" "" "" "" "" "" "" "" "89.1" "74.7" "78.7" "70.8" "83.7" "77.3" "85.2" "65.3" "70.9" "104.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972887412222597887" "False" "High" "IsMasterProtein" "Q9UIS9" "Methyl-CpG-binding domain protein 1 OS=Homo sapiens OX=9606 GN=MBD1 PE=1 SV=2" "0.000" "False" "8.705" "5" "3" "3" "3" "605" "66.6" "9.04" "9.56" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf02008" "4152" "ENSG00000141644" "MBD1" "A4UTZ0; B4DXJ5; E9PEC5; hsa:4152; K7ELI2; K7EQZ4; K7ESN0; O15248; O95241; Q7Z7B5; Q8N4W4; Q9UIS9; Q9UNZ6; Q9UNZ7; Q9UNZ8; Q9UNZ9" "SUMOylation of transcription cofactors" "Sudden infant death syndrome (SIDS) susceptibility pathways" "2" "0" "0.972" "0.645" "0.893" "0.844" "0.829" "0.892" "0.813" "0.780" "1.687" "49.0" "47.7" "31.6" "43.8" "41.4" "40.7" "43.7" "39.8" "38.3" "82.7" "" "" "" "" "" "" "" "" "" "" "44.3" "36.8" "24.5" "29.5" "34.5" "34.7" "37.1" "28.8" "25.8" "82.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340121106600756603" "False" "High" "IsMasterProtein" "Q9UPY3" "Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3" "0.000" "False" "8.698" "1" "1" "1" "1" "1922" "218.5" "5.68" "4.45" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00636, Pf02170, Pf03368, Pf20930, Pf20931, Pf20932" "23405" "ENSG00000100697" "DICER1" "A7E2D3; B3KRG4; E0AD28; hsa:23405; O95943; Q9UPY3; Q9UQ02" "M-decay: degradation of maternal mRNAs by maternally stored factors; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Hypoxia-mediated EMT and stemness; mRNA processing; Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "11" "0" "0.917" "0.834" "1.072" "0.997" "0.769" "0.843" "0.768" "0.965" "2.386" "176.0" "161.4" "146.7" "188.7" "175.5" "135.4" "148.5" "135.2" "170.0" "420.1" "" "" "" "" "" "" "" "" "" "" "158.9" "124.5" "113.5" "127.1" "146.4" "115.6" "125.9" "97.8" "114.6" "420.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9085174644749999284" "False" "High" "IsMasterProtein" "Q4G0F5" "Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2" "0.000" "False" "8.697" "9" "3" "3" "2" "336" "39.1" "7.36" "8.84" "3" "stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "112936" "ENSG00000151502" "VPS26B" "hsa:112936; Q4G0F5; Q96A55" "" "" "0" "0" "0.930" "0.983" "1.269" "0.989" "0.893" "0.966" "1.037" "1.037" "0.739" "127.1" "118.3" "124.9" "161.3" "125.7" "113.5" "122.7" "131.8" "131.8" "93.9" "" "" "" "" "" "" "" "" "" "" "114.7" "91.2" "96.6" "108.6" "104.8" "96.8" "104.1" "95.4" "88.9" "93.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4174205388023222362" "False" "High" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "0.000" "False" "8.684" "8" "2" "2" "2" "258" "28.8" "6.65" "7.26" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "HCMV Late Events; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "0" "0.969" "1.024" "1.066" "0.968" "0.966" "1.024" "0.917" "0.919" "1.007" "161.0" "156.0" "164.9" "171.5" "155.8" "155.5" "164.9" "147.6" "148.0" "162.1" "" "" "" "" "" "" "" "" "" "" "145.3" "120.3" "127.5" "115.5" "130.0" "132.7" "139.9" "106.8" "99.8" "162.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2375435199137725135" "False" "High" "IsMasterProtein" "Q96MH2" "Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1" "0.000" "False" "8.679" "7" "2" "3" "1" "286" "32.4" "6.55" "10.53" "2" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "124790" "ENSG00000168517" "HEXIM2" "D3DX66; hsa:124790; Q96MH2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706468280429092974" "False" "High" "IsMasterProtein" "Q9Y3S2" "Zinc finger protein 330 OS=Homo sapiens OX=9606 GN=ZNF330 PE=1 SV=1" "0.000" "False" "8.671" "9" "3" "3" "3" "320" "36.2" "6.16" "7.45" "3" "" "nucleus;other cell component" "other molecular function" "Pf06524" "27309" "ENSG00000109445" "ZNF330" "B2RDA3; hsa:27309; Q9Y3S2" "" "" "0" "0" "0.861" "1.082" "1.114" "0.824" "1.078" "1.091" "0.964" "1.036" "1.417" "178.9" "154.1" "193.7" "199.4" "147.4" "192.8" "195.3" "172.4" "185.3" "253.5" "" "" "" "" "" "" "" "" "" "" "161.5" "118.8" "149.8" "134.3" "123.0" "164.5" "165.6" "124.8" "125.0" "253.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1584990058854155939" "False" "High" "IsMasterProtein" "Q9NPI6" "mRNA-decapping enzyme 1A OS=Homo sapiens OX=9606 GN=DCP1A PE=1 SV=3" "0.000" "False" "8.671" "4" "2" "2" "2" "582" "63.2" "6.25" "5.19" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "55802" "ENSG00000272886" "DCP1A" "B4DHN9; hsa:55802; Q9NPI6; U3KQM8" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "TGF-beta signaling pathway" "5" "0" "1.144" "1.034" "1.219" "1.160" "0.962" "1.285" "1.014" "1.019" "1.786" "44.1" "50.4" "45.6" "53.7" "51.1" "42.4" "56.6" "44.7" "44.9" "78.7" "" "" "" "" "" "" "" "" "" "" "39.8" "38.9" "35.3" "36.2" "42.6" "36.2" "48.0" "32.3" "30.3" "78.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3992202401745413050" "False" "High" "IsMasterProtein" "O75044" "SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3" "0.000" "False" "8.665" "3" "3" "3" "3" "1071" "120.8" "6.70" "8.88" "3" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00611, Pf00620" "23380" "ENSG00000266028" "SRGAP2" "A2RUF3; hsa:23380; O75044" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate Formins; RAC3 GTPase cycle; RHOF GTPase cycle; RHOU GTPase cycle; Inactivation of CDC42 and RAC1" "" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5610453000666898366" "False" "High" "IsMasterProtein" "Q6RFH5" "WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1" "0.000" "False" "8.644" "5" "2" "2" "2" "385" "42.4" "8.32" "5.71" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "54663" "ENSG00000133316" "WDR74" "A8K8G5; hsa:54663; Q6RFH5; Q9BRC9; Q9H6X8; Q9NVY2" "" "" "0" "0" "1.086" "0.765" "1.144" "1.121" "0.867" "1.071" "0.956" "1.097" "0.773" "62.7" "68.1" "48.0" "71.7" "70.3" "54.3" "67.1" "59.9" "68.7" "48.5" "" "" "" "" "" "" "" "" "" "" "56.6" "52.5" "37.1" "48.3" "58.6" "46.3" "57.0" "43.3" "46.3" "48.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8049844811418031107" "False" "High" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "0.000" "False" "8.637" "10" "2" "3" "2" "220" "25.4" "10.07" "9.48" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "tRNA processing in the nucleus" "" "1" "0" "0.991" "1.007" "0.819" "1.142" "0.845" "1.136" "1.147" "0.908" "0.952" "50.3" "49.8" "50.6" "41.2" "57.4" "42.5" "57.1" "57.7" "45.6" "47.9" "" "" "" "" "" "" "" "" "" "" "45.4" "38.4" "39.1" "27.7" "47.9" "36.3" "48.4" "41.7" "30.8" "47.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2257664793413269493" "False" "High" "IsMasterProtein" "Q69YN2" "CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2" "0.000" "False" "8.614" "6" "4" "4" "4" "538" "60.6" "7.24" "11.26" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity" "Pf04676, Pf04677" "55280" "ENSG00000095485" "CWF19L1" "B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13" "" "" "0" "0" "1.103" "0.893" "1.228" "1.011" "1.018" "1.280" "0.995" "1.067" "1.456" "130.6" "144.1" "116.7" "160.4" "132.1" "133.0" "167.2" "130.0" "139.4" "190.2" "" "" "" "" "" "" "" "" "" "" "117.9" "111.1" "90.2" "108.0" "110.2" "113.5" "141.9" "94.0" "94.1" "190.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933297728605715540" "False" "High" "IsMasterProtein" "Q9UIK4" "Death-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=DAPK2 PE=1 SV=1" "0.000" "False" "8.609" "5" "2" "2" "2" "370" "42.9" "6.92" "4.67" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "23604" "ENSG00000035664" "DAPK2" "E9JGM7; hsa:23604; O75892; Q24JS1; Q9UIK4" "Caspase activation via Dependence Receptors in the absence of ligand" "Bladder cancer; 7q11.23 distal copy number variation" "3" "0" "0.808" "0.618" "0.838" "0.944" "0.839" "0.880" "0.906" "0.715" "0.689" "146.8" "118.6" "90.8" "123.0" "138.6" "123.2" "129.1" "133.0" "104.9" "101.1" "" "" "" "" "" "" "" "" "" "" "132.5" "91.5" "70.2" "82.8" "115.6" "105.1" "109.5" "96.2" "70.8" "101.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6346583217180848630" "False" "High" "IsMasterProtein" "P09601" "Heme oxygenase 1 OS=Homo sapiens OX=9606 GN=HMOX1 PE=1 SV=1" "0.000" "False" "8.603" "8" "2" "3" "2" "288" "32.8" "8.25" "10.92" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01126" "3162" "ENSG00000100292" "HMOX1" "hsa:3162; P09601" "Heme signaling; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Cytoprotection by HMOX1; Interleukin-4 and Interleukin-13 signaling; Regulation of HMOX1 expression and activity; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Iron uptake and transport; Heme degradation" "Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Overview of nanoparticle effects; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Lung fibrosis; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; IL-10 anti-inflammatory signaling pathway ; IL-18 signaling pathway; CAMKK2 pathway; Opioid receptor pathways; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Urotensin-II-mediated signaling pathway" "25" "0" "1.060" "1.372" "1.099" "0.928" "1.352" "1.086" "1.085" "1.398" "0.798" "247.8" "262.7" "340.1" "272.3" "230.0" "335.1" "269.2" "268.8" "346.5" "197.8" "" "" "" "" "" "" "" "" "" "" "223.7" "202.7" "263.0" "183.3" "191.9" "286.0" "228.3" "194.5" "233.7" "197.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634316393020217319" "False" "High" "IsMasterProtein" "Q5VZE5" "N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1" "0.000" "False" "8.593" "3" "2" "2" "2" "725" "83.6" "7.05" "6.69" "2" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04112" "60560" "ENSG00000135040" "NAA35" "hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "1.069" "0.778" "1.143" "1.051" "0.848" "0.877" "0.938" "0.867" "0.784" "212.7" "227.3" "165.4" "243.2" "223.5" "180.4" "186.5" "199.5" "184.5" "166.7" "" "" "" "" "" "" "" "" "" "" "192.0" "175.3" "128.0" "163.8" "186.4" "153.9" "158.2" "144.4" "124.4" "166.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8961190954250988131" "False" "High" "IsMasterProtein" "Q16891" "MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1" "0.000" "False" "8.591" "3" "2" "2" "2" "758" "83.6" "6.48" "7.59" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09731" "10989" "ENSG00000132305" "IMMT" "B1H0U5; B2R5N6; hsa:10989; Q14539; Q15092; Q16891; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2" "Cristae formation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7855128710481582123" "False" "High" "IsMasterProtein" "P50238" "Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3" "0.000" "False" "8.586" "21" "2" "5" "2" "77" "8.5" "8.75" "13.62" "2" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00412" "1396" "ENSG00000213145" "CRIP1" "H3BPI2; hsa:1396; P50238; Q13628; Q53XY7; Q96J34" "" "" "0" "0" "0.987" "1.065" "0.942" "0.977" "0.985" "1.004" "1.168" "1.109" "0.656" "479.4" "473.1" "510.8" "451.7" "468.2" "472.3" "481.2" "560.2" "531.6" "314.4" "" "" "" "" "" "" "" "" "" "" "432.8" "365.0" "395.1" "304.2" "390.6" "403.1" "408.2" "405.4" "358.6" "314.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7524352490741382419" "False" "High" "IsMasterProtein" "O14972" "Vacuolar protein sorting-associated protein 26C OS=Homo sapiens OX=9606 GN=VPS26C PE=1 SV=1" "0.000" "False" "8.582" "6" "1" "1" "1" "297" "33.0" "7.68" "5.31" "1" "transport" "other cytoplasmic organelle" "" "Pf03643" "10311" "ENSG00000157538" "VPS26C" "B2R6T8; B7Z6B1; D3DSH4; hsa:10311; O14972; Q2TAY6" "" "" "0" "0" "0.941" "1.085" "1.112" "0.735" "0.946" "0.982" "0.944" "1.205" "0.972" "47.3" "44.5" "51.3" "52.6" "34.8" "44.7" "46.4" "44.6" "57.0" "45.9" "" "" "" "" "" "" "" "" "" "" "42.7" "34.3" "39.7" "35.4" "29.0" "38.2" "39.3" "32.3" "38.4" "45.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5200719085873833637" "False" "High" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "0.000" "False" "8.562" "6" "3" "4" "3" "434" "48.3" "7.93" "12.34" "3" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialic acid metabolism" "Sialylation" "2" "0" "1.129" "0.832" "1.080" "1.128" "0.777" "1.128" "1.003" "0.846" "1.118" "140.6" "158.8" "117.0" "151.9" "158.7" "109.2" "158.6" "141.1" "119.0" "157.2" "" "" "" "" "" "" "" "" "" "" "127.0" "122.5" "90.5" "102.3" "132.4" "93.2" "134.5" "102.1" "80.2" "157.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538184499835993456" "False" "High" "IsMasterProtein" "P43897" "Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2" "0.000" "False" "8.562" "6" "2" "2" "2" "325" "35.4" "8.38" "6.14" "2" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "Pf00889" "10102" "ENSG00000123297" "TSFM" "B4E391; F5H2T7; hsa:10102; P43897; Q561V7; Q8TBC2; Q9UQK0" "Mitochondrial translation elongation" "" "1" "0" "1.115" "1.143" "1.099" "1.108" "1.121" "1.256" "0.444" "1.020" "11.089" "58.2" "64.9" "66.5" "63.9" "64.5" "65.2" "73.1" "25.8" "59.3" "645.1" "" "" "" "" "" "" "" "" "" "" "52.5" "50.0" "51.4" "43.0" "53.8" "55.6" "62.0" "18.7" "40.0" "645.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5687850324260335343" "False" "High" "IsMasterProtein" "Q16875" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens OX=9606 GN=PFKFB3 PE=1 SV=1" "0.000" "False" "8.552" "6" "3" "3" "2" "520" "59.6" "8.21" "10.23" "3" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5209" "ENSG00000170525" "PFKFB3" "B7Z955; hsa:5209; O43622; O75902; Q16875; Q5VX15; Q5VX18; Q5VX19" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "3" "0" "1.015" "0.912" "1.053" "1.064" "0.897" "1.051" "1.058" "0.941" "0.803" "141.9" "144.0" "129.4" "149.4" "151.0" "127.2" "149.1" "150.2" "133.6" "114.0" "" "" "" "" "" "" "" "" "" "" "128.1" "111.1" "100.1" "100.6" "126.0" "108.6" "126.5" "108.7" "90.1" "114.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569062232649936506" "False" "High" "IsMasterProtein" "Q9NVH2" "Integrator complex subunit 7 OS=Homo sapiens OX=9606 GN=INTS7 PE=1 SV=1" "0.000" "False" "8.521" "2" "1" "1" "1" "962" "106.8" "8.02" "5.42" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "" "25896" "ENSG00000143493" "INTS7" "B4DLZ6; B7WNP6; B7WPB6; hsa:25896; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVH2; Q9NVU5; Q9UFC6; Q9UFM3" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.247" "1.219" "1.469" "0.755" "0.844" "1.501" "1.070" "1.062" "1.902" "21.4" "26.7" "26.1" "31.5" "16.2" "18.1" "32.2" "22.9" "22.7" "40.7" "" "" "" "" "" "" "" "" "" "" "19.3" "20.6" "20.2" "21.2" "13.5" "15.4" "27.3" "16.6" "15.3" "40.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4399142244827454415" "False" "High" "IsMasterProtein" "Q8NFD5" "AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3" "0.000" "False" "8.514" "1" "1" "2" "1" "2319" "243.8" "6.90" "7.49" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "57492" "ENSG00000049618" "ARID1B" "hsa:57492; Q5JRD1; Q5VYC4; Q8IZY8; Q8NFD5; Q8TEV0; Q8TF02; Q99491; Q9ULI5" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "0.888" "1.071" "1.119" "0.954" "1.183" "0.954" "0.990" "1.126" "1.144" "99.1" "88.0" "106.2" "110.9" "94.6" "117.3" "94.6" "98.1" "111.7" "113.4" "" "" "" "" "" "" "" "" "" "" "89.5" "67.9" "82.1" "74.7" "78.9" "100.1" "80.2" "71.0" "75.3" "113.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4878144000314540155" "False" "High" "IsMasterProtein" "Q9NWU5" "Large ribosomal subunit protein uL22m OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1" "0.000" "False" "8.512" "17" "3" "3" "3" "206" "23.6" "9.94" "5.59" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00237" "29093" "ENSG00000082515" "MRPL22" "A6NGJ8; hsa:29093; Q5H9Q1; Q96Q51; Q9NWU5; Q9P006" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.009" "1.055" "1.097" "1.161" "1.070" "1.088" "0.840" "0.984" "1.218" "38.7" "39.1" "40.9" "42.5" "45.0" "41.5" "42.2" "32.5" "38.1" "47.2" "" "" "" "" "" "" "" "" "" "" "35.0" "30.2" "31.6" "28.6" "37.5" "35.4" "35.8" "23.5" "25.7" "47.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011365371626777610" "False" "High" "IsMasterProtein" "P56277" "Cx9C motif-containing protein 4 OS=Homo sapiens OX=9606 GN=CMC4 PE=1 SV=1" "0.000" "False" "8.498" "25" "2" "3" "2" "68" "7.7" "8.18" "10.05" "2" "" "mitochondrion" "" "Pf08991" "100272147" "ENSG00000182712" "CMC4" "hsa:100272147; P56277; Q5HYP9" "Mitochondrial protein import" "" "1" "0" "1.147" "1.182" "1.110" "1.084" "1.185" "1.116" "1.228" "1.056" "0.720" "97.4" "111.7" "115.0" "108.1" "105.6" "115.4" "108.6" "119.5" "102.8" "70.1" "" "" "" "" "" "" "" "" "" "" "87.9" "86.1" "89.0" "72.8" "88.1" "98.5" "92.1" "86.5" "69.3" "70.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291509197618805102" "False" "High" "IsMasterProtein" "Cont_Q3SZ57" "Alpha-fetoprotein OS=Bos taurus OX=9913 GN=AFP PE=2 SV=1" "0.000" "True" "8.496" "6" "4" "7" "3" "610" "68.5" "6.29" "17.66" "4" "other metabolic processes;developmental processes;signal transduction" "non-structural extracellular;other cell component" "other molecular function" "Pf00273" "506011" "ENSBIXG00000005150; ENSBTAG00000017131" "AFP" "A0A4W2DDK5; bta:506011; Q3SZ57" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "1.356" "1.049" "1.690" "1.697" "1.466" "1.125" "1.111" "1.790" "0.830" "42.9" "58.2" "45.0" "72.5" "72.8" "62.9" "48.2" "47.7" "76.8" "35.6" "" "" "" "" "" "" "" "" "" "" "38.7" "44.9" "34.8" "48.8" "60.7" "53.7" "40.9" "34.5" "51.8" "35.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7838191573175713795" "False" "High" "IsMasterProtein" "Q9Y4B5" "Microtubule cross-linking factor 1 OS=Homo sapiens OX=9606 GN=MTCL1 PE=1 SV=5" "0.000" "False" "8.483" "1" "2" "2" "2" "1905" "209.4" "6.43" "5.97" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf11365, Pf14818" "23255" "ENSG00000168502" "MTCL1" "E9PAY7; hsa:23255; Q6ZMQ9; Q8IWA9; Q9Y4B5" "" "" "0" "0" "1.069" "1.411" "1.334" "1.080" "1.454" "1.103" "1.107" "1.300" "2.789" "90.6" "96.9" "127.9" "120.9" "97.9" "131.8" "100.0" "100.3" "117.9" "252.8" "" "" "" "" "" "" "" "" "" "" "81.8" "74.8" "98.9" "81.4" "81.7" "112.5" "84.8" "72.6" "79.5" "252.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972522835468462088" "False" "High" "IsMasterProtein" "O43432" "Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2" "0.000" "False" "8.468" "1" "3" "4" "1" "1585" "176.5" "5.38" "11.11" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "8672" "ENSG00000075151" "EIF4G3" "B9EGQ7; hsa:8672; O43432; Q15597; Q504Z1; Q5SWC3; Q8NEN1" "ISG15 antiviral mechanism" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3464311242002607672" "False" "High" "IsMasterProtein" "P86790" "Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1" "0.000" "False" "8.460" "4" "2" "3" "2" "482" "55.8" "6.48" "5.88" "2" "transport" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf19031, Pf19032, Pf19033" "221960; 51622" "ENSG00000146574" "CCZ1B" "A2RU45; hsa:221960; hsa:51622; O95766; P86790; Q9UG65; Q9Y359" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.927" "0.963" "1.121" "0.863" "1.146" "1.149" "1.014" "1.150" "1.200" "22.9" "21.2" "22.1" "25.7" "19.8" "26.3" "26.3" "23.2" "26.3" "27.5" "" "" "" "" "" "" "" "" "" "" "20.7" "16.4" "17.1" "17.3" "16.5" "22.4" "22.3" "16.8" "17.8" "27.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1355905293603533123" "False" "High" "IsMasterProtein" "Q9Y2Z2" "Protein MTO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MTO1 PE=1 SV=2" "0.000" "False" "8.459" "3" "2" "2" "2" "717" "79.9" "8.31" "6.57" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01134, Pf13932, Pf21680" "25821" "ENSG00000135297" "MTO1" "B3KQB5; hsa:25821; Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; Q9Y2Z2" "tRNA modification in the mitochondrion" "" "1" "0" "1.195" "1.066" "1.332" "1.151" "0.890" "1.323" "1.099" "0.886" "2.076" "43.0" "51.4" "45.8" "57.3" "49.5" "38.3" "56.9" "47.2" "38.1" "89.3" "" "" "" "" "" "" "" "" "" "" "38.8" "39.6" "35.5" "38.6" "41.3" "32.6" "48.3" "34.2" "25.7" "89.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "107248944887719922" "False" "High" "IsMasterProtein" "Q6VN20" "Ran-binding protein 10 OS=Homo sapiens OX=9606 GN=RANBP10 PE=1 SV=1" "0.000" "False" "8.454" "4" "2" "2" "2" "620" "67.2" "6.77" "6.24" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf00622, Pf08513, Pf10607" "57610" "ENSG00000141084" "RANBP10" "A4FTY2; B4DID0; B4DQH9; E7EW27; hsa:57610; Q6VN20; Q9P264" "MET activates RAS signaling" "Ciliary landscape" "2" "0" "0.912" "0.729" "1.087" "0.969" "0.748" "0.826" "0.835" "0.878" "1.451" "85.9" "78.3" "62.6" "93.4" "83.2" "64.3" "71.0" "71.7" "75.5" "124.6" "" "" "" "" "" "" "" "" "" "" "77.5" "60.4" "48.4" "62.9" "69.4" "54.8" "60.2" "51.9" "50.9" "124.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5704352961259904218" "False" "High" "IsMasterProtein" "Q14155" "Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2" "0.000" "False" "8.442" "3" "2" "2" "2" "803" "90.0" "7.09" "2.73" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16614, Pf16615" "8874" "ENSG00000102606" "ARHGEF7" "B1ALK6; B1ALK8; hsa:8874; Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1" "RHOV GTPase cycle; RHOU GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; Ephrin signaling; RHOA GTPase cycle; CDC42 GTPase cycle; G alpha (12/13) signalling events; RHOQ GTPase cycle; RHOJ GTPase cycle; EGFR downregulation" "Integrin-mediated cell adhesion; CAMKK2 pathway; Regulation of actin cytoskeleton" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305631654265975414" "False" "High" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "0.000" "False" "8.438" "7" "2" "3" "2" "262" "29.3" "9.79" "10.96" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "Mitochondrial translation termination" "" "1" "0" "0.911" "0.985" "0.964" "0.958" "0.990" "0.966" "1.049" "0.935" "1.475" "331.5" "301.9" "326.5" "319.7" "317.7" "328.2" "320.3" "347.8" "310.1" "489.1" "" "" "" "" "" "" "" "" "" "" "299.2" "232.9" "252.5" "215.3" "265.0" "280.1" "271.7" "251.7" "209.2" "489.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3617199734258832058" "False" "High" "IsMasterProtein" "Q9BZQ8" "Protein Niban 1 OS=Homo sapiens OX=9606 GN=NIBAN1 PE=1 SV=1" "0.000" "False" "8.432" "3" "2" "2" "2" "928" "103.1" "4.78" "5.37" "2" "stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "" "" "116496" "ENSG00000135842" "NIBAN1" "hsa:116496; Q2TTR2; Q5TEM8; Q8TEI5; Q9BZQ8; Q9H593; Q9H9Y8; Q9HCB9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7316364973511523624" "False" "High" "IsMasterProtein" "Q8IYI6" "Exocyst complex component 8 OS=Homo sapiens OX=9606 GN=EXOC8 PE=1 SV=2" "0.000" "False" "8.419" "5" "4" "4" "4" "725" "81.7" "5.49" "11.10" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf08700, Pf16528" "149371" "ENSG00000116903" "EXOC8" "B3KU33; hsa:149371; Q5TE82; Q8IYI6" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "RalA downstream regulated genes; Ciliary landscape" "5" "0" "1.053" "0.930" "1.040" "1.049" "0.797" "0.961" "0.789" "0.968" "4.220" "70.5" "74.3" "65.6" "73.3" "74.0" "56.2" "67.8" "55.6" "68.2" "297.7" "" "" "" "" "" "" "" "" "" "" "63.7" "57.3" "50.7" "49.4" "61.7" "48.0" "57.5" "40.3" "46.0" "297.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3933155493213774730" "False" "High" "IsMasterProtein" "Cont_Q3SZV7" "Hemopexin OS=Bos taurus OX=9913 GN=HPX PE=2 SV=1" "0.000" "True" "8.414" "5" "3" "4" "3" "459" "52.2" "7.80" "11.28" "3" "other metabolic processes;transport;other biological processes" "non-structural extracellular" "transporter activity;other molecular function" "Pf00045" "534509" "ENSBIXG00000017851" "HPX" "A0A4W2EKG5; bta:534509; Q3SZV7" "" "" "0" "0" "1.096" "1.126" "1.092" "1.145" "1.364" "0.992" "0.981" "1.420" "0.989" "148.5" "162.7" "167.1" "162.2" "170.0" "202.5" "147.3" "145.7" "210.8" "146.9" "" "" "" "" "" "" "" "" "" "" "134.0" "125.5" "129.3" "109.2" "141.8" "172.8" "124.9" "105.4" "142.2" "146.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4429006779143257910" "False" "High" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "0.000" "False" "8.414" "6" "2" "2" "2" "339" "40.2" "6.83" "6.70" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "mRNA Splicing - Major Pathway" "" "1" "0" "0.790" "1.012" "0.916" "0.836" "0.938" "0.894" "0.834" "0.895" "2.125" "88.9" "70.2" "90.0" "81.5" "74.3" "83.4" "79.5" "74.1" "79.6" "188.9" "" "" "" "" "" "" "" "" "" "" "80.2" "54.2" "69.6" "54.8" "62.0" "71.2" "67.4" "53.6" "53.7" "188.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-279239733910497261" "False" "High" "IsMasterProtein" "Q8NAV1" "Pre-mRNA-splicing factor 38A OS=Homo sapiens OX=9606 GN=PRPF38A PE=1 SV=1" "0.000" "False" "8.408" "4" "1" "4" "1" "312" "37.5" "9.96" "6.06" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371, Pf12871" "84950" "ENSG00000134748" "PRPF38A" "hsa:84950; Q8NAV1; Q96JW1; Q9BVZ8" "mRNA Splicing - Major Pathway" "MECP2 and associated Rett syndrome" "2" "0" "0.952" "0.842" "1.165" "1.044" "0.911" "1.173" "0.807" "0.580" "0.868" "27.2" "25.9" "22.9" "31.7" "28.4" "24.8" "31.9" "21.9" "15.8" "23.6" "" "" "" "" "" "" "" "" "" "" "24.5" "20.0" "17.7" "21.3" "23.7" "21.1" "27.1" "15.9" "10.6" "23.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8448471456180421378" "False" "High" "IsMasterProtein" "Q9P275" "Ubiquitin carboxyl-terminal hydrolase 36 OS=Homo sapiens OX=9606 GN=USP36 PE=1 SV=4" "0.000" "False" "8.396" "2" "1" "1" "1" "1123" "122.8" "9.70" "6.74" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57602" "ENSG00000055483" "USP36" "hsa:57602; Q05C98; Q05DD0; Q6IQ38; Q8NDM8; Q9NVC8; Q9P275" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9116145290149312693" "False" "High" "IsMasterProtein" "P42226" "Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1" "0.000" "False" "8.375" "2" "2" "2" "2" "847" "94.1" "6.23" "5.71" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf14596, Pf21354" "6778" "ENSG00000166888" "STAT6" "A8K316; B7ZA27; F5GXI9; hsa:6778; P42226; Q5FBW5; Q71UP4" "Downstream signal transduction; Interleukin-4 and Interleukin-13 signaling; STAT6-mediated induction of chemokines" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Adipogenesis; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; PDGFR-beta pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-19 signaling pathway" "13" "0" "0.939" "1.071" "1.284" "1.234" "0.858" "1.203" "0.836" "1.020" "6.955" "48.8" "45.9" "52.3" "62.7" "60.3" "41.9" "58.7" "40.8" "49.8" "339.6" "" "" "" "" "" "" "" "" "" "" "44.1" "35.4" "40.4" "42.2" "50.3" "35.7" "49.8" "29.5" "33.6" "339.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4572995838386066943" "False" "High" "IsMasterProtein" "Q13568" "Interferon regulatory factor 5 OS=Homo sapiens OX=9606 GN=IRF5 PE=1 SV=2" "0.000" "False" "8.366" "2" "1" "2" "1" "498" "56.0" "5.77" "5.59" "1" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3663" "ENSG00000128604" "IRF5" "A4D1J8; A8DUA8; A8DUA9; E7EQ16; E7EW54; hsa:3663; Q13568; Q1A7B4; Q64GA9; Q64GB1; Q64GB2; Q6RCM8; Q9BQF0" "Interferon gamma signaling; Interferon alpha/beta signaling" "Apoptosis; Vitamin D receptor pathway; miRNA role in immune response in sepsis; p53 transcriptional gene network; Genes associated with the development of rheumatoid arthritis; Orexin receptor pathway; Toll-like receptor signaling pathway" "9" "0" "1.073" "1.060" "0.899" "1.008" "1.295" "0.978" "1.107" "1.141" "2.643" "49.9" "53.6" "52.9" "44.9" "50.4" "64.7" "48.8" "55.3" "57.0" "132.0" "" "" "" "" "" "" "" "" "" "" "45.1" "41.3" "40.9" "30.2" "42.0" "55.2" "41.4" "40.0" "38.4" "132.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824590419555307181" "False" "High" "IsMasterProtein" "P63165" "Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1" "0.000" "False" "8.364" "19" "2" "4" "2" "101" "11.6" "5.52" "11.64" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf11976" "7341" "ENSG00000116030" "SUMO1" "A8MUS8; B2R4I5; hsa:7341; P55856; P63165; Q6FGG0; Q6NZ62; Q93068" "PKR-mediated signaling; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Formation of Incision Complex in GG-NER; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "Androgen receptor signaling pathway; TP53 network; TGF-beta signaling pathway; Exercise-induced circadian regulation" "27" "0" "0.959" "1.324" "0.946" "0.940" "1.315" "0.952" "0.919" "1.297" "1.728" "258.5" "247.9" "342.3" "244.6" "243.0" "340.1" "246.1" "237.6" "335.4" "446.7" "" "" "" "" "" "" "" "" "" "" "233.4" "191.2" "264.8" "164.7" "202.7" "290.2" "208.8" "172.0" "226.2" "446.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3349657221176052038" "False" "High" "IsMasterProtein" "O00750" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta OS=Homo sapiens OX=9606 GN=PIK3C2B PE=1 SV=2" "0.000" "False" "8.357" "1" "1" "1" "1" "1634" "184.7" "7.30" "4.55" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5287" "ENSG00000133056" "PIK3C2B" "hsa:5287; O00750; O95666; Q5SW99" "Synthesis of PIPs at the plasma membrane" "Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "8" "0" "0.906" "0.906" "1.057" "1.168" "1.395" "1.065" "0.963" "1.096" "2.109" "21.3" "19.3" "19.3" "22.5" "24.9" "29.7" "22.7" "20.5" "23.4" "44.9" "" "" "" "" "" "" "" "" "" "" "19.2" "14.9" "14.9" "15.2" "20.8" "25.4" "19.3" "14.8" "15.8" "44.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4154792399073788951" "False" "High" "IsMasterProtein" "Q13541" "Eukaryotic translation initiation factor 4E-binding protein 1 OS=Homo sapiens OX=9606 GN=EIF4EBP1 PE=1 SV=3" "0.000" "False" "8.353" "32" "2" "6" "2" "118" "12.6" "5.48" "13.62" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05456" "1978" "ENSG00000187840" "EIF4EBP1" "B2R502; D3DSW8; hsa:1978; Q13541; Q6IBN3" "mTORC1-mediated signalling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" "Translation factors; AMP-activated protein kinase signaling; Target of rapamycin signaling; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; RAC1/PAK1/p38/MMP2 pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Hypertrophy model; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway" "32" "0" "1.257" "1.047" "0.992" "1.187" "1.177" "1.063" "1.085" "1.068" "0.757" "62.3" "78.3" "65.2" "61.8" "74.0" "73.3" "66.2" "67.6" "66.5" "47.2" "" "" "" "" "" "" "" "" "" "" "56.2" "60.4" "50.5" "41.6" "61.7" "62.6" "56.2" "48.9" "44.9" "47.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296645769357171248" "False" "High" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "0.000" "False" "8.351" "4" "2" "2" "2" "582" "66.9" "9.55" "7.13" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.974" "2.589" "1.129" "1.036" "2.461" "0.963" "0.962" "2.465" "2.528" "58.5" "57.0" "151.5" "66.1" "60.6" "144.0" "56.4" "56.3" "144.2" "147.9" "" "" "" "" "" "" "" "" "" "" "52.8" "43.9" "117.1" "44.5" "50.6" "122.9" "47.8" "40.7" "97.3" "147.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1086525266732812690" "False" "High" "IsMasterProtein" "Q9Y5P4" "Ceramide transfer protein OS=Homo sapiens OX=9606 GN=CERT1 PE=1 SV=1" "0.000" "False" "8.350" "4" "2" "2" "2" "624" "70.8" "5.48" "7.15" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus" "transporter activity;kinase activity;other molecular function" "Pf00169, Pf01852" "10087" "ENSG00000113163" "CERT1" "A8K7S2; B3KUB7; hsa:10087; Q53YV1; Q53YV2; Q96Q85; Q96Q88; Q9H2S7; Q9H2S8; Q9Y5P4" "" "Sphingolipid pathway" "1" "0" "1.141" "1.098" "1.098" "1.001" "1.049" "1.122" "0.872" "1.130" "3.116" "100.4" "114.5" "110.3" "110.2" "100.5" "105.3" "112.6" "87.6" "113.5" "312.8" "" "" "" "" "" "" "" "" "" "" "90.6" "88.4" "85.3" "74.2" "83.8" "89.9" "95.6" "63.4" "76.5" "312.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5104969040472016970" "False" "High" "IsMasterProtein" "Q13576" "Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4" "0.000" "False" "8.342" "1" "2" "2" "1" "1575" "180.5" "5.64" "7.16" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "10788" "ENSG00000145703" "IQGAP2" "A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576" "Neutrophil degranulation; RHO GTPases activate IQGAPs; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle" "Ciliary landscape; G13 signaling pathway" "7" "0" "0.948" "0.753" "0.993" "0.981" "0.846" "1.013" "0.834" "0.774" "6.671" "60.3" "57.2" "45.4" "59.9" "59.2" "51.0" "61.1" "50.3" "46.7" "402.3" "" "" "" "" "" "" "" "" "" "" "54.4" "44.1" "35.1" "40.3" "49.3" "43.6" "51.8" "36.4" "31.5" "402.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031077161766424227" "False" "High" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "0.000" "False" "8.341" "3" "3" "3" "3" "841" "95.9" "5.11" "9.10" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400; ENSG00000292219" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "0.993" "1.218" "1.273" "1.027" "1.447" "1.088" "0.868" "1.247" "2.468" "40.4" "40.1" "49.2" "51.4" "41.5" "58.4" "43.9" "35.0" "50.3" "99.6" "" "" "" "" "" "" "" "" "" "" "36.4" "30.9" "38.0" "34.6" "34.6" "49.9" "37.3" "25.4" "33.9" "99.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2647028449518715682" "False" "High" "IsMasterProtein" "P16383" "Intron Large complex component GCFC2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2" "0.000" "False" "8.335" "5" "2" "2" "2" "781" "89.3" "5.99" "8.30" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf07842" "6936" "ENSG00000005436" "GCFC2" "A4UHQ8; A4UHQ9; hsa:6936; O95032; P16383; Q53TY0; Q6P2F2" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580197304848334652" "False" "High" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "0.000" "False" "8.333" "4" "3" "3" "3" "603" "69.9" "8.18" "9.57" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "0.962" "0.962" "0.982" "1.045" "0.977" "0.912" "0.925" "1.018" "0.777" "314.5" "302.7" "302.6" "308.9" "328.7" "307.3" "286.9" "291.0" "320.2" "244.2" "" "" "" "" "" "" "" "" "" "" "283.9" "233.5" "234.1" "208.0" "274.2" "262.3" "243.3" "210.6" "216.0" "244.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3645624783218300571" "False" "High" "IsMasterProtein" "Q96CG3" "TRAF-interacting protein with FHA domain-containing protein A OS=Homo sapiens OX=9606 GN=TIFA PE=1 SV=1" "0.000" "False" "8.328" "13" "3" "3" "3" "184" "21.4" "5.11" "9.25" "3" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00498" "92610" "ENSG00000145365" "TIFA" "hsa:92610; Q96CG3" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "4" "0" "1.037" "0.888" "0.955" "0.986" "0.917" "0.921" "1.058" "0.895" "0.841" "358.0" "371.2" "317.9" "341.7" "353.1" "328.5" "329.6" "378.7" "320.4" "301.3" "" "" "" "" "" "" "" "" "" "" "323.2" "286.3" "245.9" "230.1" "294.5" "280.4" "279.6" "274.0" "216.1" "301.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9220853686183247090" "False" "High" "IsMasterProtein" "Cont_P01966" "Hemoglobin subunit alpha OS=Bos taurus OX=9913 GN=HBA PE=1 SV=2" "0.000" "True" "8.325" "11" "1" "2" "1" "142" "15.2" "8.44" "7.65" "1" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "100140149; 109578761; 512439" "ENSBIXG00000028763; ENSBIXG00005026352; ENSBTAG00000051412" "GLNC1; HBA; LOC109578761; LOC113883300" "A0A1K0FUD3; A0A4W2IFB1; A0A6P5DZW6; A3KN13; biu:109578761; bta:100140149; bta:512439; P01966; Q3SZE0; Q9TTR9; Q9TTS0; Q9TTS1" "Cytoprotection by HMOX1; Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Heme signaling; Erythrocytes take up oxygen and release carbon dioxide" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357414389544456501" "False" "High" "IsMasterProtein" "P55212" "Caspase-6 OS=Homo sapiens OX=9606 GN=CASP6 PE=1 SV=2" "0.000" "False" "8.312" "8" "3" "3" "2" "293" "33.3" "6.93" "7.90" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656" "839" "ENSG00000138794" "CASP6" "hsa:839; P55212; Q9BQE7" "TP53 Regulates Transcription of Caspase Activators and Caspases; Caspase-mediated cleavage of cytoskeletal proteins; Breakdown of the nuclear lamina" "Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Acute viral myocarditis" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962045687038046175" "False" "High" "IsMasterProtein" "Q8NEC7" "Glutathione S-transferase C-terminal domain-containing protein OS=Homo sapiens OX=9606 GN=GSTCD PE=1 SV=2" "0.000" "False" "8.311" "4" "2" "2" "2" "633" "71.0" "7.78" "7.28" "2" "" "other cell component" "other molecular function" "Pf13679" "79807" "ENSG00000138780" "GSTCD" "A8K8J0; A8MVD3; H9KV97; hsa:79807; Q8NEC7; Q9H8S3" "" "Metapathway biotransformation Phase I and II" "1" "0" "0.829" "0.836" "1.068" "0.858" "0.832" "0.854" "0.869" "0.799" "1.555" "188.5" "156.2" "157.5" "201.4" "161.7" "156.9" "160.9" "163.8" "150.5" "293.2" "" "" "" "" "" "" "" "" "" "" "170.1" "120.5" "121.9" "135.6" "134.9" "133.9" "136.5" "118.5" "101.5" "293.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3147119451307441974" "False" "High" "IsMasterProtein" "Q96MU7" "YTH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=YTHDC1 PE=1 SV=3" "0.000" "False" "8.307" "3" "3" "4" "3" "727" "84.6" "6.23" "10.87" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf04146" "91746" "ENSG00000083896; ENSG00000275272" "YTHDC1" "hsa:91746; Q4W5Q3; Q7Z622; Q8TF35; Q96MU7" "" "" "0" "0" "0.899" "3.700" "1.075" "0.819" "3.293" "0.960" "0.967" "3.647" "1.907" "82.1" "73.8" "303.8" "88.3" "67.3" "270.4" "78.8" "79.4" "299.4" "156.5" "" "" "" "" "" "" "" "" "" "" "74.1" "56.9" "235.0" "59.4" "56.1" "230.8" "66.9" "57.4" "202.0" "156.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5334275938705899592" "False" "High" "IsMasterProtein" "O00512" "B-cell CLL/lymphoma 9 protein OS=Homo sapiens OX=9606 GN=BCL9 PE=1 SV=4" "0.000" "False" "8.289" "1" "2" "2" "2" "1426" "149.2" "8.91" "7.61" "2" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf11502" "607" "ENSG00000116128" "BCL9" "hsa:607; O00512; Q5T489" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex" "Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; 1q21.1 copy number variation syndrome" "5" "0" "1.061" "0.821" "1.027" "0.935" "1.018" "0.917" "1.106" "1.063" "0.924" "69.9" "74.1" "57.4" "71.7" "65.3" "71.2" "64.1" "77.3" "74.3" "64.6" "" "" "" "" "" "" "" "" "" "" "63.1" "57.2" "44.4" "48.3" "54.5" "60.7" "54.3" "55.9" "50.1" "64.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566941551472469516" "False" "High" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "0.000" "False" "8.283" "6" "3" "3" "3" "579" "65.5" "7.06" "6.69" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "mRNA processing" "5" "0" "0.944" "1.033" "0.892" "0.941" "0.996" "0.938" "0.876" "1.135" "0.604" "178.0" "168.1" "183.9" "158.7" "167.4" "177.3" "167.0" "156.0" "202.1" "107.6" "" "" "" "" "" "" "" "" "" "" "160.7" "129.6" "142.2" "106.9" "139.7" "151.3" "141.7" "112.9" "136.3" "107.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002757993896463050" "False" "High" "IsMasterProtein" "Q9NQW6" "Anillin OS=Homo sapiens OX=9606 GN=ANLN PE=1 SV=2" "0.000" "False" "8.275" "1" "1" "1" "1" "1124" "124.1" "8.07" "5.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00169, Pf08174, Pf16018" "54443" "ENSG00000011426" "ANLN" "hsa:54443; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NQW6; Q9NVN9; Q9NVP0" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "Retinoblastoma gene in cancer; Nephrotic syndrome" "5" "0" "1.236" "1.464" "1.026" "0.992" "1.380" "1.251" "0.856" "1.520" "8.556" "53.4" "66.1" "78.3" "54.9" "53.0" "73.7" "66.9" "45.7" "81.2" "457.3" "" "" "" "" "" "" "" "" "" "" "48.2" "51.0" "60.5" "36.9" "44.2" "62.9" "56.7" "33.1" "54.8" "457.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2146106311129589736" "False" "High" "IsMasterProtein" "P35244" "Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1" "0.000" "False" "8.270" "21" "2" "2" "2" "121" "13.6" "5.08" "6.05" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08661" "6119" "ENSG00000106399" "RPA3" "hsa:6119; P35244; Q549U6" "HSF1 activation; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "36" "0" "1.581" "2.188" "1.205" "1.555" "1.961" "1.631" "1.357" "1.836" "2.180" "21.2" "33.5" "46.3" "25.5" "32.9" "41.5" "34.5" "28.7" "38.9" "46.2" "" "" "" "" "" "" "" "" "" "" "19.1" "25.8" "35.8" "17.2" "27.5" "35.4" "29.3" "20.8" "26.2" "46.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2091961222017639990" "False" "High" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "0.000" "False" "8.264" "5" "3" "3" "3" "557" "65.6" "6.64" "7.94" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "mRNA Splicing - Major Pathway" "" "1" "0" "1.111" "1.237" "0.879" "0.966" "1.090" "0.960" "1.031" "1.241" "1.653" "116.4" "129.3" "144.1" "102.3" "112.5" "127.0" "111.7" "120.1" "144.6" "192.5" "" "" "" "" "" "" "" "" "" "" "105.1" "99.8" "111.5" "68.9" "93.8" "108.4" "94.8" "86.9" "97.5" "192.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4573891914704923062" "False" "High" "IsMasterProtein" "Q9BTE1" "Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1" "0.000" "False" "8.259" "6" "1" "2" "1" "182" "20.1" "8.02" "5.92" "1" "developmental processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf21711" "84516" "ENSG00000166847" "DCTN5" "A8K9X8; H3BN51; H3BQA4; hsa:84516; Q9BTE1" "COPI-mediated anterograde transport; MHC class II antigen presentation; COPI-independent Golgi-to-ER retrograde traffic; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "Vasopressin-regulated water reabsorption" "5" "0" "1.068" "1.094" "0.992" "1.088" "1.006" "1.071" "1.141" "1.098" "0.897" "113.9" "121.6" "124.6" "113.0" "123.9" "114.6" "122.0" "129.9" "125.0" "102.1" "" "" "" "" "" "" "" "" "" "" "102.8" "93.8" "96.4" "76.1" "103.4" "97.8" "103.5" "94.0" "84.3" "102.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175952193399053833" "False" "High" "IsMasterProtein" "P50748" "Kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=KNTC1 PE=1 SV=1" "0.000" "False" "8.242" "2" "4" "4" "4" "2209" "250.6" "5.97" "9.41" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10493" "9735" "ENSG00000184445" "KNTC1" "A7E2C4; B3KSG2; hsa:9735; P50748" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "0.786" "0.789" "0.793" "1.071" "0.821" "1.077" "0.608" "1.035" "1.970" "16.8" "13.2" "13.3" "13.3" "18.0" "13.8" "18.1" "10.2" "17.4" "33.1" "" "" "" "" "" "" "" "" "" "" "15.2" "10.2" "10.3" "9.0" "15.0" "11.8" "15.4" "7.4" "11.7" "33.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088626010110122517" "False" "High" "IsMasterProtein" "Q9UJX6" "Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1" "0.000" "False" "8.240" "4" "3" "3" "3" "822" "93.8" "5.22" "9.61" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00888, Pf08672" "29882" "ENSG00000176248" "ANAPC2" "hsa:29882; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1; Q9UJX6" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Senescence-Associated Secretory Phenotype (SASP); Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "1.103" "0.857" "1.054" "0.984" "0.928" "0.990" "1.011" "0.916" "1.218" "149.8" "165.2" "128.4" "157.9" "147.5" "139.0" "148.2" "151.4" "137.2" "182.4" "" "" "" "" "" "" "" "" "" "" "135.2" "127.5" "99.3" "106.3" "123.0" "118.6" "125.7" "109.6" "92.5" "182.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2812564218304631981" "False" "High" "IsMasterProtein" "Q9NRD1" "F-box only protein 6 OS=Homo sapiens OX=9606 GN=FBXO6 PE=1 SV=1" "0.000" "False" "8.238" "8" "2" "2" "2" "293" "33.9" "6.09" "6.96" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf04300, Pf12937" "26270" "ENSG00000116663" "FBXO6" "B1AK42; B2RC88; hsa:26270; Q9NRD1; Q9UKT3" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "" "3" "0" "0.883" "1.154" "1.245" "1.536" "1.098" "1.460" "1.286" "1.471" "1.383" "22.5" "19.9" "25.9" "28.0" "34.5" "24.7" "32.8" "28.9" "33.1" "31.1" "" "" "" "" "" "" "" "" "" "" "20.3" "15.3" "20.1" "18.9" "28.8" "21.1" "27.9" "20.9" "22.3" "31.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4248741172720899665" "False" "High" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "0.000" "False" "8.233" "25" "2" "5" "2" "92" "10.8" "9.44" "14.17" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "mRNA processing" "8" "0" "1.114" "1.033" "1.001" "0.849" "1.066" "0.971" "0.887" "1.005" "0.900" "61.2" "68.2" "63.2" "61.2" "52.0" "65.3" "59.4" "54.3" "61.5" "55.1" "" "" "" "" "" "" "" "" "" "" "55.2" "52.6" "48.9" "41.2" "43.4" "55.7" "50.4" "39.3" "41.5" "55.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1899154642705730358" "False" "High" "IsMasterProtein" "Q9UNK0" "Syntaxin-8 OS=Homo sapiens OX=9606 GN=STX8 PE=1 SV=2" "0.000" "False" "8.233" "11" "2" "2" "2" "236" "26.9" "4.98" "6.62" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739" "9482" "ENSG00000170310" "STX8" "hsa:9482; O60712; Q53XT8; Q9UNK0" "" "" "0" "0" "1.190" "1.168" "1.241" "1.153" "1.030" "1.340" "1.172" "1.053" "0.914" "98.9" "117.7" "115.5" "122.7" "114.0" "101.8" "132.6" "115.9" "104.1" "90.4" "" "" "" "" "" "" "" "" "" "" "89.3" "90.8" "89.3" "82.6" "95.1" "86.9" "112.5" "83.9" "70.2" "90.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7997158032231502372" "False" "High" "IsMasterProtein" "Q9Y6D9" "Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2" "0.000" "False" "8.232" "4" "3" "3" "3" "718" "83.0" "5.92" "7.18" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05557" "8379" "ENSG00000002822" "MAD1L1" "B3KR41; hsa:8379; Q13312; Q75MI0; Q86UM4; Q9UNH0; Q9Y6D9" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma; CCL18 signaling pathway" "10" "0" "1.055" "1.035" "0.928" "0.943" "0.893" "0.715" "0.710" "0.982" "1.670" "18.8" "19.8" "19.5" "17.5" "17.7" "16.8" "13.4" "13.4" "18.5" "31.4" "" "" "" "" "" "" "" "" "" "" "17.0" "15.3" "15.0" "11.8" "14.8" "14.3" "11.4" "9.7" "12.5" "31.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6208634135307330971" "False" "High" "IsMasterProtein" "P17480" "Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1" "0.000" "False" "8.231" "3" "2" "2" "2" "764" "89.4" "5.81" "7.17" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011, Pf14887" "7343" "ENSG00000108312" "UBTF" "A8K6R8; hsa:7343; P17480" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening" "Ectoderm differentiation" "6" "0" "1.147" "1.752" "1.197" "1.012" "1.927" "1.021" "0.944" "1.836" "1.438" "115.1" "132.0" "201.5" "137.7" "116.4" "221.7" "117.5" "108.6" "211.2" "165.4" "" "" "" "" "" "" "" "" "" "" "103.9" "101.8" "155.9" "92.7" "97.1" "189.3" "99.6" "78.6" "142.5" "165.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1703725255333180782" "False" "High" "IsMasterProtein" "O14530" "Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2" "0.000" "False" "8.220" "14" "4" "5" "4" "226" "26.5" "5.88" "13.20" "4" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00085" "10190" "ENSG00000115514" "TXNDC9" "B2R9G8; D3DVI4; hsa:10190; O14530; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6" "" "" "0" "0" "1.120" "0.780" "0.916" "0.921" "0.856" "0.855" "0.749" "0.784" "0.791" "98.4" "110.2" "76.8" "90.2" "90.6" "84.3" "84.1" "73.7" "77.2" "77.8" "" "" "" "" "" "" "" "" "" "" "88.8" "85.0" "59.4" "60.7" "75.6" "71.9" "71.4" "53.4" "52.1" "77.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3796638279955905475" "False" "High" "IsMasterProtein" "Q9NZ32" "Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1" "0.000" "False" "8.215" "6" "2" "2" "2" "417" "46.3" "7.37" "6.82" "2" "transport" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "" "Pf00022" "55860" "ENSG00000131966" "ACTR10" "hsa:55860; Q9H9Y5; Q9NWY2; Q9NZ32" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "" "5" "0" "1.161" "1.213" "1.022" "0.897" "0.978" "1.320" "1.087" "0.930" "0.966" "54.7" "63.6" "66.4" "56.0" "49.1" "53.5" "72.2" "59.5" "50.9" "52.9" "" "" "" "" "" "" "" "" "" "" "49.4" "49.0" "51.4" "37.7" "41.0" "45.7" "61.3" "43.1" "34.3" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1697211468385276031" "False" "High" "IsMasterProtein" "P62861" "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=2" "0.000" "False" "8.214" "13" "2" "3" "2" "133" "14.4" "10.17" "8.24" "2" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00240, Pf04758" "2197" "ENSG00000149806" "FAU" "hsa:2197; P35544; P62861; Q05472; Q95261; Q9H5V4" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-374289036912732411" "False" "High" "IsMasterProtein" "Q15042" "Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3" "0.000" "False" "8.213" "2" "2" "2" "2" "981" "110.5" "5.55" "6.21" "2" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf13890, Pf19533" "22930" "ENSG00000115839" "RAB3GAP1" "A6H8Z3; C9J837; hsa:22930; Q15042; Q659F5; Q8TBB4" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "" "2" "0" "0.984" "1.139" "1.023" "0.970" "0.938" "1.136" "0.453" "1.016" "6.852" "108.1" "106.4" "123.2" "110.7" "104.9" "101.5" "122.9" "49.0" "109.9" "741.0" "" "" "" "" "" "" "" "" "" "" "97.6" "82.1" "95.3" "74.5" "87.5" "86.6" "104.2" "35.4" "74.1" "741.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5274992111862833065" "False" "High" "IsMasterProtein" "Q8IXJ6" "NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2" "0.000" "False" "8.192" "7" "3" "3" "3" "389" "43.2" "5.36" "8.44" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02146" "22933" "ENSG00000068903; ENSG00000283100" "SIRT2" "A8K3V1; B2RB45; hsa:22933; O95889; Q8IXJ6; Q924Y7; Q9P0G8; Q9UNT0; Q9Y6E9; U5TP13" "Initiation of Nuclear Envelope (NE) Reformation" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; HDAC6 interactions in the central nervous system" "5" "0" "0.969" "1.153" "1.450" "1.246" "1.207" "1.188" "1.001" "1.466" "1.095" "21.9" "21.2" "25.2" "31.8" "27.3" "26.4" "26.0" "21.9" "32.1" "24.0" "" "" "" "" "" "" "" "" "" "" "19.8" "16.4" "19.5" "21.4" "22.8" "22.6" "22.1" "15.9" "21.6" "24.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5544959501066740394" "False" "High" "IsMasterProtein" "Cont_P02666" "Beta-casein OS=Bos taurus OX=9913 GN=CSN2 PE=1 SV=2" "0.000" "True" "8.189" "8" "1" "1" "1" "224" "25.1" "5.35" "5.77" "1" "stress response;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00363" "104997418; 109560545; 281099" "" "CSN2" "A0A1U9XAM2; A0A6P3I767; A1YQZ8; A6N8V0; bbis:104997418; biu:109560545; L8I8G5; P02666; Q2TA13; Q5EEQ6; Q5EEQ7; Q6UN63; Q9BDG5; Q9TSD5" "" "" "0" "0" "1.301" "1.033" "1.178" "0.939" "1.044" "1.123" "0.918" "1.704" "1.458" "51.4" "66.8" "53.1" "60.5" "48.2" "53.6" "57.7" "47.2" "87.5" "74.9" "" "" "" "" "" "" "" "" "" "" "46.4" "51.6" "41.1" "40.7" "40.2" "45.8" "48.9" "34.1" "59.0" "74.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7472508916157269106" "False" "High" "IsMasterProtein" "Q9H9P8" "L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3" "0.000" "False" "8.182" "5" "2" "2" "2" "463" "50.3" "8.15" "6.49" "2" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01266" "79944" "ENSG00000087299" "L2HGDH" "hsa:79944; Q9BRR1; Q9H9P8" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "Cerebral organic acidurias, including diseases" "2" "0" "1.011" "0.939" "0.968" "0.997" "0.815" "1.045" "1.042" "0.937" "0.814" "144.5" "146.1" "135.7" "139.9" "144.1" "117.8" "151.1" "150.7" "135.4" "117.7" "" "" "" "" "" "" "" "" "" "" "130.5" "112.7" "105.0" "94.2" "120.2" "100.5" "128.1" "109.0" "91.3" "117.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1239693809215146352" "False" "High" "IsMasterProtein" "P37275" "Zinc finger E-box-binding homeobox 1 OS=Homo sapiens OX=9606 GN=ZEB1 PE=1 SV=2" "0.000" "False" "8.140" "1" "1" "1" "1" "1124" "124.0" "4.94" "4.19" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf05605" "6935" "ENSG00000148516" "ZEB1" "B4DJV0; B4DUW9; E9PCM7; F5H4I8; hsa:6935; P37275; Q12924; Q13800; Q2KJ05; Q5T968; Q5VZ84; Q8NB68" "Interleukin-4 and Interleukin-13 signaling" "Hypoxia-mediated EMT and stemness; TGF-beta signaling pathway; Clear cell renal cell carcinoma pathways; Epithelial to mesenchymal transition in colorectal cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; CCL18 signaling pathway; Hypertrophy model" "8" "0" "1.051" "1.303" "1.100" "0.932" "1.284" "1.189" "1.090" "1.322" "1.019" "56.9" "59.7" "74.1" "62.5" "53.0" "73.0" "67.6" "62.0" "75.2" "57.9" "" "" "" "" "" "" "" "" "" "" "51.3" "46.1" "57.3" "42.1" "44.2" "62.3" "57.3" "44.8" "50.7" "57.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5656635003875974689" "False" "High" "IsMasterProtein" "Q13111" "Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3" "0.000" "False" "8.140" "1" "1" "1" "1" "956" "106.8" "5.94" "4.84" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf11600, Pf12253, Pf15539, Pf15557" "10036" "ENSG00000167670" "CHAF1A" "hsa:10036; Q13111; Q6NXG5; Q7Z7K3; Q9UJY8" "" "Nanoparticle triggered autophagic cell death" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480687027944615342" "False" "High" "IsMasterProtein" "Q8NHG8" "E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1" "0.000" "False" "8.112" "11" "2" "2" "2" "242" "24.1" "7.09" "7.08" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13639" "223082" "ENSG00000180233" "ZNRF2" "Q8NHG8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8889615092674929040" "False" "High" "IsMasterProtein" "Q04721" "Neurogenic locus notch homolog protein 2 OS=Homo sapiens OX=9606 GN=NOTCH2 PE=1 SV=3" "0.000" "False" "8.105" "1" "2" "2" "2" "2471" "265.2" "5.14" "6.63" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00008, Pf00066, Pf06816, Pf07645, Pf07684, Pf12661, Pf12796" "4853" "ENSG00000134250" "NOTCH2" "hsa:4853; Q04721; Q5T3X7; Q99734; Q9H240" "NOTCH2 Activation and Transmission of Signal to the Nucleus; Pre-NOTCH Processing in Golgi; Pre-NOTCH Transcription and Translation; Notch-HLH transcription pathway; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; Pre-NOTCH Processing in the Endoplasmic Reticulum; Defective LFNG causes SCDO3" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; OSX and miRNAs in tooth development; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; Genes controlling nephrogenesis; Nephrogenesis; Primary ovarian insufficiency; Notch signaling pathway" "20" "0" "0.784" "0.908" "0.882" "0.756" "0.767" "0.820" "1.003" "0.897" "0.418" "64.1" "50.3" "58.2" "56.5" "48.5" "49.2" "52.6" "64.3" "57.5" "26.8" "" "" "" "" "" "" "" "" "" "" "57.9" "38.8" "45.0" "38.1" "40.4" "42.0" "44.6" "46.5" "38.8" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338471368414013319" "False" "High" "IsMasterProtein" "Q96T60" "Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens OX=9606 GN=PNKP PE=1 SV=1" "0.000" "False" "8.092" "4" "2" "2" "2" "521" "57.0" "8.46" "7.83" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf08645, Pf13671, Pf17913" "11284" "ENSG00000039650" "PNKP" "hsa:11284; Q96T60; Q9BUL2; Q9P1V2; Q9UKU8; Q9UNF8; Q9UNI0" "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" "Base excision repair; DNA repair pathways, full network" "3" "0" "1.101" "0.902" "1.137" "1.185" "0.782" "1.185" "1.033" "0.898" "1.762" "59.8" "65.9" "53.9" "68.0" "70.9" "46.8" "70.9" "61.8" "53.7" "105.4" "" "" "" "" "" "" "" "" "" "" "54.0" "50.8" "41.7" "45.8" "59.2" "39.9" "60.1" "44.7" "36.2" "105.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2300421444410781361" "False" "High" "IsMasterProtein" "Q9BRP1" "Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1" "0.000" "False" "8.089" "7" "3" "4" "3" "358" "39.4" "4.86" "10.85" "3" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf04194" "84306" "ENSG00000126249" "PDCD2L" "hsa:84306; Q9BRP1" "" "" "0" "0" "0.918" "1.089" "1.054" "0.948" "1.001" "0.965" "0.779" "1.136" "2.026" "203.7" "186.9" "221.8" "214.8" "193.2" "203.9" "196.6" "158.8" "231.4" "412.8" "" "" "" "" "" "" "" "" "" "" "183.9" "144.2" "171.5" "144.7" "161.1" "174.0" "166.7" "114.9" "156.0" "412.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218003044822153883" "False" "High" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "0.000" "False" "8.083" "12" "2" "6" "2" "172" "19.2" "5.40" "15.44" "2" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "1.024" "1.221" "1.116" "1.074" "1.138" "1.106" "1.158" "1.190" "1.272" "166.6" "170.5" "203.3" "185.9" "178.8" "189.6" "184.1" "192.8" "198.2" "211.8" "" "" "" "" "" "" "" "" "" "" "150.4" "131.5" "157.3" "125.2" "149.2" "161.8" "156.2" "139.6" "133.7" "211.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991903496179440797" "False" "High" "IsMasterProtein" "A8CG34" "Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3" "0.000" "False" "8.075" "3" "2" "2" "2" "1229" "125.0" "10.37" "5.54" "2" "transport" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf15229" "" "ENSG00000272391" "POM121C" "A0A075B7F8; A0A087WY75; A8CG34; O75115; Q9Y2N3; Q9Y4S7" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004394019571150397" "False" "High" "IsMasterProtein" "P25942" "Tumor necrosis factor receptor superfamily member 5 OS=Homo sapiens OX=9606 GN=CD40 PE=1 SV=1" "0.000" "False" "8.067" "7" "2" "2" "2" "277" "30.6" "5.76" "7.09" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00020" "958" "ENSG00000101017" "CD40" "E1P5S9; hsa:958; P25942; Q53GN5; Q5JY15; Q5U007; Q7M4Q8; Q86YK5; Q9BYU0" "" "Allograft rejection; Complement system; Vitamin D receptor pathway; Nod-like receptor (NLR) signaling pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Platelet-mediated interactions with vascular and circulating cells; Inflammatory response pathway; Genes associated with the development of rheumatoid arthritis; Extrafollicular and follicular B cell activation by SARS-CoV-2; Toll-like receptor signaling pathway" "10" "0" "1.120" "1.040" "1.119" "0.990" "0.902" "1.073" "1.130" "0.849" "0.760" "359.0" "402.0" "373.3" "401.7" "355.5" "323.7" "385.2" "405.6" "304.9" "272.9" "" "" "" "" "" "" "" "" "" "" "324.1" "310.1" "288.8" "270.5" "296.6" "276.3" "326.8" "293.5" "205.6" "272.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1899835700088576048" "False" "High" "IsMasterProtein" "O14656" "Torsin-1A OS=Homo sapiens OX=9606 GN=TOR1A PE=1 SV=1" "0.000" "False" "8.054" "3" "1" "1" "1" "332" "37.8" "6.99" "4.29" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "1861" "ENSG00000136827" "TOR1A" "B2RB58; hsa:1861; O14656; Q53Y64; Q96CA0" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "0" "0.887" "0.782" "1.009" "0.981" "0.809" "0.876" "0.873" "0.724" "0.666" "113.3" "100.5" "88.6" "114.4" "111.2" "91.7" "99.3" "99.0" "82.0" "75.5" "" "" "" "" "" "" "" "" "" "" "102.3" "77.5" "68.5" "77.0" "92.8" "78.2" "84.2" "71.6" "55.3" "75.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837878793854205649" "False" "High" "IsMasterProtein" "Q9BVL2" "Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1" "0.000" "False" "8.052" "4" "3" "3" "3" "599" "60.9" "9.33" "9.65" "3" "transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf15967" "9818" "ENSG00000139496" "NUP58" "A6NI12; B4DZJ1; hsa:9818; O43160; Q5JRG2; Q5JRG5; Q9BVL2" "" "" "0" "0" "1.044" "0.874" "0.954" "0.968" "0.888" "0.992" "1.163" "0.882" "0.835" "390.5" "407.6" "341.2" "372.6" "378.1" "346.9" "387.4" "454.2" "344.5" "326.0" "" "" "" "" "" "" "" "" "" "" "352.5" "314.4" "263.9" "250.9" "315.4" "296.1" "328.6" "328.7" "232.4" "326.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5357467251583528977" "False" "High" "IsMasterProtein" "Q49AR2" "UPF0489 protein C5orf22 OS=Homo sapiens OX=9606 GN=C5orf22 PE=1 SV=2" "0.000" "False" "8.046" "6" "2" "3" "2" "442" "49.9" "4.78" "10.56" "2" "" "" "" "Pf12640" "55322" "ENSG00000082213" "C5orf22" "hsa:55322; Q49AR2; Q8ND28; Q8WU61; Q9NUR1" "" "" "0" "0" "1.013" "1.193" "0.899" "0.974" "1.088" "0.975" "0.995" "1.138" "0.998" "426.3" "431.7" "508.8" "383.4" "415.0" "463.7" "415.5" "424.2" "485.0" "425.5" "" "" "" "" "" "" "" "" "" "" "384.8" "333.0" "393.5" "258.2" "346.2" "395.7" "352.5" "307.0" "327.2" "425.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2426417921420304223" "False" "High" "IsMasterProtein" "Q13523" "Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRP4K PE=1 SV=3" "0.000" "False" "8.021" "2" "2" "2" "2" "1007" "116.9" "10.26" "6.30" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8899" "ENSG00000112739" "PRPF4B" "A8K5C9; hsa:8899; Q13523; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.144" "0.926" "0.858" "1.094" "1.057" "1.012" "1.040" "1.047" "0.921" "75.2" "86.0" "69.6" "64.5" "82.3" "79.5" "76.1" "78.2" "78.7" "69.2" "" "" "" "" "" "" "" "" "" "" "67.9" "66.3" "53.9" "43.5" "68.6" "67.9" "64.6" "56.6" "53.1" "69.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316200197019601200" "False" "High" "IsMasterProtein" "Q9Y3I1" "F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1" "0.000" "False" "8.012" "4" "2" "3" "2" "522" "58.5" "6.55" "7.61" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00646, Pf11566" "25793" "ENSG00000100225" "FBXO7" "B4DNB3; B4DWX5; hsa:25793; Q5TGC4; Q5TI86; Q96HM6; Q9UF21; Q9UKT2; Q9Y3I1" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4923515790283792107" "False" "High" "IsMasterProtein" "Q7Z309" "PABIR family member 2 OS=Homo sapiens OX=9606 GN=PABIR2 PE=1 SV=2" "0.000" "False" "8.006" "6" "1" "2" "1" "247" "26.9" "6.37" "6.07" "1" "" "" "enzyme regulator activity" "" "159090" "ENSG00000156504" "PABIR2" "A8K902; hsa:159090; Q6PIM2; Q6ZU47; Q6ZV64; Q6ZVE4; Q7Z309; Q8TB75" "" "" "0" "0" "1.072" "0.975" "1.078" "0.947" "0.933" "0.975" "0.947" "0.896" "0.630" "44.7" "47.9" "43.5" "48.2" "42.3" "41.7" "43.5" "42.3" "40.0" "28.1" "" "" "" "" "" "" "" "" "" "" "40.3" "36.9" "33.7" "32.4" "35.3" "35.6" "36.9" "30.6" "27.0" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5882151393090730100" "False" "High" "IsMasterProtein" "Q8TA86" "Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2" "0.000" "False" "7.997" "8" "2" "5" "2" "221" "26.1" "9.79" "14.64" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6100" "ENSG00000164610" "RP9" "hsa:6100; Q8TA86" "" "" "0" "0" "1.037" "1.139" "1.115" "0.976" "0.929" "1.055" "1.185" "0.939" "0.594" "124.4" "129.0" "141.8" "138.7" "121.4" "115.6" "131.3" "147.5" "116.8" "73.9" "" "" "" "" "" "" "" "" "" "" "112.3" "99.5" "109.7" "93.4" "101.3" "98.6" "111.4" "106.8" "78.8" "73.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564485370032939878" "False" "High" "IsMasterProtein" "Q9UBV8" "Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1" "0.000" "False" "7.981" "10" "3" "4" "3" "284" "30.4" "6.54" "10.04" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf13405, Pf13499" "553115" "ENSG00000162517" "PEF1" "hsa:553115; Q9UBV8" "" "" "0" "0" "0.965" "1.107" "0.981" "1.029" "1.225" "1.010" "1.031" "1.120" "0.980" "383.9" "370.6" "424.8" "376.6" "395.2" "470.2" "387.8" "395.8" "429.9" "376.3" "" "" "" "" "" "" "" "" "" "" "346.5" "285.8" "328.6" "253.6" "329.6" "401.3" "329.0" "286.4" "290.0" "376.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6795582567929622559" "False" "High" "IsMasterProtein" "P61916" "NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1" "0.000" "False" "7.973" "16" "3" "3" "3" "151" "16.6" "7.65" "8.84" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf02221" "10577" "ENSG00000119655" "NPC2" "B4DQV7; P61916; Q15668; Q29413" "Neutrophil degranulation; LDL clearance" "TYROBP causal network in microglia; Degradation pathway of sphingolipids, including diseases; Ebola virus infection in host; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "7" "0" "1.028" "1.017" "0.892" "0.933" "1.033" "1.062" "1.051" "1.068" "0.758" "359.2" "369.3" "365.3" "320.4" "335.2" "371.2" "381.3" "377.5" "383.7" "272.4" "" "" "" "" "" "" "" "" "" "" "324.3" "284.9" "282.5" "215.8" "279.6" "316.8" "323.5" "273.2" "258.8" "272.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1340431599886036183" "False" "High" "IsMasterProtein" "O60783" "Small ribosomal subunit protein uS14m OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1" "0.000" "False" "7.957" "12" "1" "2" "1" "128" "15.1" "11.41" "6.99" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00253" "63931" "ENSG00000120333" "MRPS14" "hsa:63931; O60783; Q5R358" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407446589588264140" "False" "High" "IsMasterProtein" "O94763" "Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3" "0.000" "False" "7.951" "5" "3" "3" "3" "535" "59.8" "5.05" "8.03" "3" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02996" "8725" "ENSG00000105176" "URI1" "A8K805; H7BY42; hsa:8725; O94763; Q8TC23; Q9UNU3" "" "" "0" "0" "0.826" "0.983" "0.875" "0.875" "0.936" "0.811" "0.780" "1.109" "0.999" "146.1" "120.7" "143.6" "127.9" "127.8" "136.8" "118.5" "114.0" "162.1" "145.9" "" "" "" "" "" "" "" "" "" "" "131.9" "93.1" "111.1" "86.1" "106.6" "116.7" "100.5" "82.5" "109.3" "145.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8070932965104358622" "False" "High" "IsMasterProtein" "Q86YS7" "C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1" "0.000" "False" "7.928" "2" "2" "2" "2" "1000" "110.4" "5.69" "6.81" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00168" "9847" "ENSG00000111731" "C2CD5" "B4DJ03; B4DRN7; B7ZLL0; F5H2A1; F5H5R1; hsa:9847; O60280; Q17RY7; Q7Z619; Q86SU3; Q86YS7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "" "1" "0" "1.008" "0.846" "0.928" "0.947" "0.827" "0.981" "0.768" "0.785" "0.742" "75.2" "75.8" "63.6" "69.7" "71.2" "62.2" "73.8" "57.7" "59.0" "55.8" "" "" "" "" "" "" "" "" "" "" "67.8" "58.5" "49.2" "47.0" "59.4" "53.1" "62.6" "41.8" "39.8" "55.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6251688870276858346" "False" "High" "IsMasterProtein" "Q9BX40" "Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1" "0.000" "False" "7.927" "9" "2" "2" "2" "385" "42.0" "9.69" "6.45" "2" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "149986" "ENSG00000149657" "LSM14B" "hsa:149986; Q6PFW8; Q96LH8; Q9BX40" "" "" "0" "0" "1.094" "1.059" "1.256" "1.146" "1.341" "1.151" "0.934" "1.010" "1.708" "47.0" "51.4" "49.8" "59.1" "53.9" "63.1" "54.1" "43.9" "47.5" "80.3" "" "" "" "" "" "" "" "" "" "" "42.5" "39.7" "38.5" "39.8" "45.0" "53.8" "45.9" "31.8" "32.0" "80.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7089722272324942505" "False" "High" "IsMasterProtein" "Q9NU23" "LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1" "0.000" "False" "7.895" "19" "2" "6" "2" "88" "10.4" "10.46" "20.35" "2" "cell organization and biogenesis" "mitochondrion" "" "Pf05347" "57226" "ENSG00000083099" "LYRM2" "B2R4U2; E1P517; hsa:57226; Q9NU23" "" "" "0" "0" "1.048" "1.025" "0.962" "1.045" "1.008" "1.007" "1.016" "1.087" "0.679" "357.0" "374.2" "366.0" "343.3" "373.1" "359.8" "359.6" "362.6" "388.1" "242.5" "" "" "" "" "" "" "" "" "" "" "322.3" "288.7" "283.1" "231.2" "311.2" "307.1" "305.1" "262.4" "261.7" "242.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5455074280924099638" "False" "High" "IsMasterProtein" "Q15554" "Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3" "0.000" "False" "7.872" "5" "3" "3" "3" "542" "59.6" "9.35" "8.10" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf08558, Pf16772" "7014" "ENSG00000132604" "TERF2" "hsa:7014; Q15554" "Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; DNA repair pathways, full network; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "17" "0" "0.985" "0.943" "0.989" "0.993" "0.848" "0.895" "0.916" "0.887" "1.628" "167.1" "164.7" "157.6" "165.2" "166.0" "141.8" "149.6" "153.1" "148.2" "272.2" "" "" "" "" "" "" "" "" "" "" "150.9" "127.0" "121.9" "111.3" "138.4" "121.0" "126.9" "110.8" "100.0" "272.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119829718007226858" "False" "High" "IsMasterProtein" "Q9UJX5" "Anaphase-promoting complex subunit 4 OS=Homo sapiens OX=9606 GN=ANAPC4 PE=1 SV=2" "0.000" "False" "7.870" "3" "2" "3" "2" "808" "92.1" "5.53" "5.80" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12894, Pf12896" "29945" "ENSG00000053900" "ANAPC4" "A8K8H1; E9PCR4; hsa:29945; Q6PCC6; Q9NSH6; Q9UJX5" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5735228591980069382" "False" "High" "IsMasterProtein" "Q9HD42" "Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1" "0.000" "False" "7.866" "12" "3" "6" "3" "196" "21.7" "8.06" "16.20" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "5119" "ENSG00000131165" "CHMP1A" "A2RU09; hsa:5119; Q14468; Q15779; Q96G31; Q9HD42" "HCMV Late Events" "" "1" "0" "1.034" "0.798" "0.982" "0.977" "0.823" "0.963" "0.978" "0.812" "0.664" "463.2" "479.1" "369.9" "455.0" "452.6" "381.0" "445.9" "453.1" "375.9" "307.5" "" "" "" "" "" "" "" "" "" "" "418.1" "369.6" "286.1" "306.4" "377.6" "325.2" "378.3" "327.9" "253.6" "307.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157929292758815644" "False" "High" "IsMasterProtein" "Q96A35" "Large ribosomal subunit protein uL24m OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" "0.000" "False" "7.864" "8" "2" "3" "2" "216" "24.9" "9.29" "8.69" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf17136" "79590" "ENSG00000143314" "MRPL24" "D3DVC8; hsa:79590; Q53G65; Q53HT0; Q5SYZ9; Q5SZ00; Q5SZ02; Q96A35; Q96Q70; Q9H7G3" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.982" "0.736" "0.903" "0.947" "0.802" "0.925" "0.895" "0.765" "0.890" "315.6" "310.0" "232.2" "285.0" "298.7" "253.0" "291.8" "282.4" "241.4" "280.7" "" "" "" "" "" "" "" "" "" "" "284.8" "239.1" "179.6" "191.9" "249.2" "216.0" "247.6" "204.4" "162.8" "280.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3778187452605941811" "False" "High" "IsMasterProtein" "Q9NZ52" "ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1" "0.000" "False" "7.863" "3" "2" "2" "2" "723" "78.3" "5.58" "4.96" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23163" "ENSG00000125447" "GGA3" "B7Z7E2; B7Z7M9; hsa:23163; J3KRN0; Q15017; Q6IS16; Q9NZ52; Q9UJY3" "Amyloid fiber formation; TBC/RABGAPs; MET receptor recycling" "" "3" "0" "0.788" "1.082" "0.788" "0.933" "1.274" "0.808" "0.740" "0.772" "1.009" "25.2" "19.9" "27.3" "19.9" "23.5" "32.1" "20.4" "18.7" "19.5" "25.4" "" "" "" "" "" "" "" "" "" "" "22.8" "15.3" "21.1" "13.4" "19.6" "27.4" "17.3" "13.5" "13.1" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7384087443166083849" "False" "High" "IsMasterProtein" "O14562" "Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens OX=9606 GN=UBFD1 PE=1 SV=2" "0.000" "False" "7.861" "6" "2" "2" "2" "309" "33.4" "5.77" "6.23" "2" "" "" "" "Pf00240" "56061" "ENSG00000103353" "UBFD1" "A8MW58; D3DWF2; hsa:56061; O14562" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "309589120852016759" "False" "High" "IsMasterProtein" "P54922" "ADP-ribosylhydrolase ARH1 OS=Homo sapiens OX=9606 GN=ADPRH PE=1 SV=1" "0.000" "False" "7.854" "8" "3" "5" "3" "357" "39.5" "6.52" "8.68" "3" "protein metabolism;other metabolic processes" "non-structural extracellular" "other molecular function" "Pf03747" "141" "ENSG00000144843" "ADPRH" "B2R8H1; D3DN83; hsa:141; P54922" "" "" "0" "0" "1.047" "1.108" "0.930" "1.054" "1.090" "1.009" "1.015" "0.988" "0.902" "109.2" "114.4" "120.9" "101.6" "115.1" "119.0" "110.2" "110.9" "107.9" "98.4" "" "" "" "" "" "" "" "" "" "" "98.6" "88.2" "93.5" "68.4" "96.0" "101.6" "93.5" "80.2" "72.8" "98.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5305679341133587567" "False" "High" "IsMasterProtein" "Q86WR0" "Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2" "0.000" "False" "7.853" "11" "3" "3" "3" "208" "24.5" "6.80" "9.03" "3" "other biological processes" "plasma membrane;other membranes;other cell component" "nucleic acid binding activity" "Pf05670" "55246" "ENSG00000147419" "CCDC25" "hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98" "" "" "0" "0" "0.851" "0.854" "0.779" "0.856" "0.835" "0.811" "0.784" "0.750" "1.153" "245.0" "208.4" "209.2" "190.7" "209.6" "204.5" "198.6" "192.1" "183.8" "282.5" "" "" "" "" "" "" "" "" "" "" "221.1" "160.7" "161.8" "128.4" "174.8" "174.6" "168.5" "139.0" "124.0" "282.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428917072824426789" "False" "High" "IsMasterProtein" "Q8NDV7" "Trinucleotide repeat-containing gene 6A protein OS=Homo sapiens OX=9606 GN=TNRC6A PE=1 SV=2" "0.000" "False" "7.853" "1" "1" "1" "1" "1962" "210.2" "7.01" "3.98" "1" "stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf10427, Pf16608" "27327" "ENSG00000090905" "TNRC6A" "C9JAR8; hsa:27327; O15408; Q658L5; Q6NVB5; Q8NDV7; Q8NEZ0; Q8TBT8; Q8TCR0; Q9NV59; Q9P268" "Oxidative Stress Induced Senescence; Ca2+ pathway; Pre-NOTCH Transcription and Translation; MAPK6/MAPK4 signaling; Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "" "19" "0" "0.944" "0.708" "1.034" "1.165" "0.562" "0.746" "0.930" "0.577" "1.065" "30.8" "29.1" "21.8" "31.8" "35.9" "17.3" "23.0" "28.7" "17.8" "32.8" "" "" "" "" "" "" "" "" "" "" "27.8" "22.4" "16.9" "21.4" "29.9" "14.8" "19.5" "20.7" "12.0" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "783704005019212775" "False" "High" "IsMasterProtein" "Q8IZ21" "Phosphatase and actin regulator 4 OS=Homo sapiens OX=9606 GN=PHACTR4 PE=1 SV=1" "0.000" "False" "7.828" "4" "3" "3" "3" "702" "78.2" "6.62" "8.34" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf02755" "65979" "ENSG00000204138" "PHACTR4" "A2APK6; B9ZVW0; D3DPM3; hsa:65979; Q68DD4; Q6NUN6; Q8IZ21; Q8N384; Q9H395; Q9H6X0; Q9H8W6" "" "" "0" "0" "0.997" "1.019" "0.810" "0.971" "1.025" "0.967" "0.928" "0.933" "0.746" "134.2" "133.7" "136.8" "108.7" "130.2" "137.5" "129.7" "124.6" "125.2" "100.1" "" "" "" "" "" "" "" "" "" "" "121.1" "103.2" "105.8" "73.2" "108.6" "117.4" "110.0" "90.1" "84.5" "100.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "968979890096343817" "False" "High" "IsMasterProtein" "P53611" "Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2" "0.000" "False" "7.811" "6" "2" "3" "2" "331" "36.9" "5.03" "10.02" "2" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00432" "5876" "ENSG00000137955" "RABGGTB" "hsa:5876; P53611; Q92697" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "" "2" "0" "0.867" "0.847" "0.860" "0.951" "0.924" "0.927" "0.790" "0.962" "1.116" "162.4" "140.7" "137.6" "139.6" "154.5" "150.1" "150.5" "128.3" "156.3" "181.3" "" "" "" "" "" "" "" "" "" "" "146.6" "108.6" "106.4" "94.0" "128.9" "128.1" "127.6" "92.9" "105.4" "181.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271823877594573979" "False" "High" "IsMasterProtein" "P27105" "Stomatin OS=Homo sapiens OX=9606 GN=STOM PE=1 SV=3" "0.000" "False" "7.807" "7" "2" "2" "2" "288" "31.7" "7.88" "5.26" "2" "other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01145" "2040" "ENSG00000148175" "STOM" "B1AM77; hsa:2040; P27105; Q14087; Q15609; Q5VX96; Q96FK4" "Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; Stimuli-sensing channels; RHOQ GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOH GTPase cycle" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Ciliary landscape" "12" "0" "1.125" "1.152" "1.285" "1.133" "0.928" "1.145" "1.065" "1.060" "0.796" "134.0" "150.8" "154.4" "172.2" "151.9" "124.4" "153.5" "142.7" "142.1" "106.7" "" "" "" "" "" "" "" "" "" "" "121.0" "116.3" "119.4" "116.0" "126.7" "106.2" "130.2" "103.3" "95.9" "106.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486365272632798294" "False" "High" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "0.000" "False" "7.802" "37" "4" "4" "4" "75" "8.7" "5.45" "11.50" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "Regulation of actin cytoskeleton" "8" "0" "0.964" "0.933" "0.991" "0.911" "0.904" "0.865" "1.035" "0.957" "1.097" "241.3" "232.7" "225.2" "239.2" "219.9" "218.1" "208.8" "249.8" "230.9" "264.7" "" "" "" "" "" "" "" "" "" "" "217.8" "179.5" "174.2" "161.1" "183.4" "186.1" "177.1" "180.8" "155.7" "264.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043384267201458756" "False" "High" "IsMasterProtein" "Q8TBX8" "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3" "0.000" "False" "7.794" "3" "1" "1" "1" "421" "47.3" "6.84" "4.47" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "79837" "ENSG00000166908" "PIP4K2C" "B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "Regulation of actin cytoskeleton" "5" "0" "1.032" "0.726" "0.963" "0.852" "0.726" "0.789" "0.845" "1.025" "2.248" "131.3" "135.5" "95.3" "126.5" "111.8" "95.4" "103.6" "110.9" "134.7" "295.3" "" "" "" "" "" "" "" "" "" "" "118.6" "104.5" "73.7" "85.2" "93.3" "81.4" "87.9" "80.3" "90.8" "295.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4676575217961373957" "False" "High" "IsMasterProtein" "P63098" "Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2" "0.000" "False" "7.784" "10" "2" "4" "2" "170" "19.3" "4.81" "13.09" "2" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "5534" "ENSG00000221823" "PPP3R1" "B2RC10; B5MDU4; hsa:5534; P06705; P15117; P63098; Q08044; Q53SL0" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; Activation of BAD and translocation to mitochondria" "Energy metabolism; Transcription factors regulate miRNAs related to cardiac hypertrophy; Alzheimer's disease and miRNA effects; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Vitamin D in inflammatory diseases; Regucalcin in proximal tubule epithelial kidney cells; Alzheimer's disease" "15" "0" "0.942" "0.934" "1.015" "0.891" "0.868" "0.894" "1.033" "0.911" "0.672" "259.7" "244.6" "242.5" "263.5" "231.3" "225.4" "232.0" "268.2" "236.5" "174.6" "" "" "" "" "" "" "" "" "" "" "234.4" "188.6" "187.5" "177.4" "193.0" "192.4" "196.8" "194.1" "159.5" "174.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576893625228470779" "False" "High" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "0.000" "False" "7.780" "10" "3" "3" "3" "356" "40.0" "7.05" "7.78" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "1.136" "1.114" "1.130" "0.935" "1.201" "1.146" "0.736" "1.059" "2.141" "65.5" "74.4" "73.0" "74.1" "61.3" "78.7" "75.1" "48.2" "69.4" "140.3" "" "" "" "" "" "" "" "" "" "" "59.2" "57.4" "56.4" "49.9" "51.1" "67.2" "63.7" "34.9" "46.8" "140.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3039666916282587145" "False" "High" "IsMasterProtein" "Q562E7" "WD repeat-containing protein 81 OS=Homo sapiens OX=9606 GN=WDR81 PE=1 SV=2" "0.000" "False" "7.778" "1" "2" "2" "2" "1941" "211.6" "5.58" "5.75" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00400, Pf02138" "124997" "ENSG00000167716; ENSG00000276021" "WDR81" "B3KW16; B3KXU1; B7Z579; E9PHG7; hsa:124997; Q24JP6; Q562E7; Q8N277; Q8N3F3; Q8TEL1" "CDC42 GTPase cycle" "" "1" "0" "0.986" "0.969" "1.230" "0.984" "0.722" "1.228" "0.748" "1.010" "5.398" "30.3" "29.8" "29.4" "37.3" "29.8" "21.9" "37.2" "22.6" "30.6" "163.5" "" "" "" "" "" "" "" "" "" "" "27.3" "23.0" "22.7" "25.1" "24.9" "18.7" "31.6" "16.4" "20.6" "163.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8114162095880212588" "False" "High" "IsMasterProtein" "Q9H3S7" "Tyrosine-protein phosphatase non-receptor type 23 OS=Homo sapiens OX=9606 GN=PTPN23 PE=1 SV=1" "0.000" "False" "7.778" "2" "3" "3" "3" "1636" "178.9" "6.92" "8.30" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102, Pf03097, Pf13949" "25930" "ENSG00000076201" "PTPN23" "A8K0D7; hsa:25930; Q7KZF8; Q8N6Z5; Q9BSR5; Q9H3S7; Q9P257; Q9UG03; Q9UMZ4" "Interleukin-37 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463522735319849849" "False" "High" "IsMasterProtein" "O15031" "Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 PE=1 SV=3" "0.000" "False" "7.774" "2" "4" "4" "4" "1838" "205.0" "6.24" "9.89" "4" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01403, Pf01437, Pf01833, Pf08337, Pf17960, Pf20170" "23654" "ENSG00000196576" "PLXNB2" "A6QRH0; hsa:23654; O15031; Q7KZU3; Q9BSU7" "" "2q11.2 copy number variation syndrome" "1" "0" "1.194" "1.140" "1.111" "1.068" "1.039" "1.165" "1.236" "1.173" "0.573" "55.4" "66.1" "63.1" "61.5" "59.1" "57.5" "64.5" "68.4" "65.0" "31.7" "" "" "" "" "" "" "" "" "" "" "50.0" "51.0" "48.8" "41.4" "49.3" "49.1" "54.7" "49.5" "43.8" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-94552620576090045" "False" "High" "IsMasterProtein" "Q8IYM9" "E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1" "0.000" "False" "7.760" "4" "2" "2" "2" "498" "56.9" "7.72" "6.19" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "10346" "ENSG00000132274" "TRIM22" "hsa:10346; Q05CQ0; Q15521; Q8IYM9" "Interferon gamma signaling" "" "1" "0" "0.981" "1.063" "1.193" "1.160" "1.126" "1.036" "0.765" "1.202" "5.380" "113.8" "111.6" "120.9" "135.8" "132.0" "128.1" "117.9" "87.0" "136.7" "612.0" "" "" "" "" "" "" "" "" "" "" "102.7" "86.1" "93.5" "91.4" "110.1" "109.3" "100.0" "63.0" "92.2" "612.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4792290450889044309" "False" "High" "IsMasterProtein" "Q96IV0" "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1" "0.000" "False" "7.754" "4" "4" "4" "4" "654" "74.3" "6.89" "10.37" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01841, Pf04721, Pf09409" "55768" "ENSG00000151092" "NGLY1" "B4DJE9; hsa:55768; Q59FB1; Q6PJD8; Q96IV0; Q9BVR8; Q9NR70" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "1" "0" "0.971" "0.907" "0.962" "0.899" "0.922" "0.951" "0.847" "0.999" "1.680" "349.2" "338.9" "316.7" "335.8" "314.1" "322.0" "331.9" "295.9" "348.8" "586.5" "" "" "" "" "" "" "" "" "" "" "315.2" "261.4" "244.9" "226.1" "262.0" "274.8" "281.6" "214.1" "235.2" "586.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5389822382155894412" "False" "High" "IsMasterProtein" "Q15223" "Nectin-1 OS=Homo sapiens OX=9606 GN=NECTIN1 PE=1 SV=3" "0.000" "False" "7.750" "4" "2" "3" "2" "517" "57.1" "6.10" "9.34" "2" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07686, Pf08205, Pf13927" "5818" "ENSG00000110400" "NECTIN1" "hsa:5818; O75465; Q15223; Q2M3D3; Q9HBE6; Q9HBW2" "Nectin/Necl trans heterodimerization" "" "2" "0" "1.022" "0.748" "0.930" "0.990" "0.774" "0.998" "1.058" "0.803" "0.616" "182.8" "186.8" "136.8" "170.0" "180.9" "141.4" "182.3" "193.3" "146.7" "112.5" "" "" "" "" "" "" "" "" "" "" "165.0" "144.1" "105.8" "114.5" "150.9" "120.7" "154.7" "139.9" "99.0" "112.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967759419043337591" "False" "High" "IsMasterProtein" "Q9UJ83" "2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2" "0.000" "False" "7.731" "3" "2" "2" "2" "578" "63.7" "7.36" "6.91" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "26061" "ENSG00000131373" "HACL1" "B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83" "Peroxisomal protein import; Alpha-oxidation of phytanate" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3431130476793294573" "False" "High" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "0.000" "False" "7.725" "10" "2" "2" "2" "188" "20.8" "9.66" "5.62" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.154" "0.964" "1.217" "1.179" "0.948" "1.194" "1.052" "0.947" "1.319" "43.7" "50.5" "42.1" "53.2" "51.6" "41.5" "52.2" "46.0" "41.4" "57.7" "" "" "" "" "" "" "" "" "" "" "39.5" "38.9" "32.6" "35.8" "43.0" "35.4" "44.3" "33.3" "27.9" "57.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5416177737731563011" "False" "High" "IsMasterProtein" "Q14457" "Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2" "0.000" "False" "7.714" "4" "2" "2" "2" "450" "51.9" "4.89" "5.71" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04111, Pf15285, Pf17675" "8678" "ENSG00000126581" "BECN1" "B2R6N7; hsa:8678; O75595; Q14457; Q9UNA8" "Macroautophagy; RSV-host interactions; Ub-specific processing proteases; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "18" "0" "1.238" "1.160" "1.232" "1.191" "1.033" "1.070" "0.897" "0.928" "1.263" "55.6" "68.8" "64.4" "68.5" "66.2" "57.4" "59.5" "49.8" "51.6" "70.2" "" "" "" "" "" "" "" "" "" "" "50.1" "53.1" "49.8" "46.1" "55.2" "49.0" "50.4" "36.1" "34.8" "70.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147390557476055838" "False" "High" "IsMasterProtein" "Q9BYT3" "Serine/threonine-protein kinase 33 OS=Homo sapiens OX=9606 GN=STK33 PE=1 SV=1" "0.000" "False" "7.705" "5" "3" "3" "3" "514" "57.8" "7.03" "8.51" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "65975" "ENSG00000130413" "STK33" "hsa:65975; Q658S6; Q8NEF5; Q9BYT3" "" "" "0" "0" "1.068" "0.838" "0.861" "1.031" "0.839" "1.054" "1.020" "0.743" "1.425" "250.6" "267.7" "210.0" "215.9" "258.5" "210.3" "264.3" "255.6" "186.2" "357.2" "" "" "" "" "" "" "" "" "" "" "226.2" "206.5" "162.4" "145.4" "215.7" "179.5" "224.2" "185.0" "125.6" "357.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7038810457230990351" "False" "High" "IsMasterProtein" "Q8NB15" "Zinc finger protein 511 OS=Homo sapiens OX=9606 GN=ZNF511 PE=1 SV=2" "0.000" "False" "7.696" "6" "1" "1" "1" "252" "28.2" "7.66" "4.99" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "118472" "ENSG00000198546" "ZNF511" "A8K8L5; hsa:118472; Q8NB15; Q8WUP1; Q96BV2" "" "" "0" "0" "1.126" "1.152" "1.071" "1.144" "1.064" "1.166" "1.056" "1.025" "0.873" "68.0" "76.6" "78.4" "72.9" "77.9" "72.4" "79.3" "71.9" "69.7" "59.4" "" "" "" "" "" "" "" "" "" "" "61.4" "59.1" "60.7" "49.1" "64.9" "61.8" "67.3" "52.0" "47.0" "59.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589862746651834702" "False" "High" "IsMasterProtein" "Q9UBW5" "Bridging integrator 2 OS=Homo sapiens OX=9606 GN=BIN2 PE=1 SV=3" "0.000" "False" "7.694" "4" "2" "2" "2" "565" "61.8" "5.15" "6.37" "2" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf03114, Pf21532" "51411" "ENSG00000110934" "BIN2" "B7Z6F3; F5H0W4; hsa:51411; Q86VV0; Q9NWK4; Q9UBW5; Q9UKN4" "Neutrophil degranulation; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "TYROBP causal network in microglia" "3" "0" "1.170" "1.390" "1.006" "1.292" "1.324" "1.164" "1.026" "1.463" "1.056" "67.3" "78.8" "93.6" "67.8" "87.0" "89.1" "78.4" "69.1" "98.5" "71.1" "" "" "" "" "" "" "" "" "" "" "60.8" "60.8" "72.4" "45.6" "72.6" "76.1" "66.5" "50.0" "66.4" "71.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2089333689475724176" "False" "High" "IsMasterProtein" "Q9BTM9" "Ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=URM1 PE=1 SV=1" "0.000" "False" "7.690" "13" "1" "2" "1" "101" "11.4" "4.67" "7.45" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf09138" "81605" "ENSG00000167118" "URM1" "B3KMH3; B4DV08; hsa:81605; Q5T4B4; Q9BTM9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.006" "1.117" "1.138" "1.131" "0.915" "1.190" "1.022" "1.388" "1.336" "18.2" "18.4" "20.4" "20.8" "20.6" "16.7" "21.7" "18.6" "25.3" "24.4" "" "" "" "" "" "" "" "" "" "" "16.5" "14.2" "15.8" "14.0" "17.2" "14.2" "18.4" "13.5" "17.1" "24.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6571071577836756123" "False" "High" "IsMasterProtein" "Q9NUP1" "Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1" "0.000" "False" "7.686" "5" "1" "2" "1" "217" "23.3" "4.98" "4.25" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;other cell component" "" "" "55330" "ENSG00000186222" "BLOC1S4" "hsa:55330; Q6NVY6; Q96G84; Q9NUP1" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "0.704" "0.964" "1.128" "1.170" "0.996" "0.927" "1.044" "0.944" "1.678" "18.9" "13.3" "18.2" "21.3" "22.1" "18.8" "17.5" "19.7" "17.8" "31.7" "" "" "" "" "" "" "" "" "" "" "17.0" "10.2" "14.1" "14.3" "18.4" "16.0" "14.8" "14.3" "12.0" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062599375234318027" "False" "High" "IsMasterProtein" "Q02447" "Transcription factor Sp3 OS=Homo sapiens OX=9606 GN=SP3 PE=1 SV=3" "0.000" "False" "7.672" "2" "1" "1" "1" "781" "81.9" "5.26" "5.24" "1" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6670" "ENSG00000172845" "SP3" "A0AVL9; B4E2B7; hsa:6670; Q02447; Q69B26; Q69B27; Q8TD56; Q8WWU4; Q9BQR1" "SUMOylation of transcription factors" "Selenium metabolism and selenoproteins; MECP2 and associated Rett syndrome; Non-genomic actions of 1,25 dihydroxyvitamin D3; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "1.230" "0.986" "1.212" "1.382" "1.059" "1.240" "1.140" "1.123" "1.050" "107.0" "131.6" "105.5" "129.7" "147.9" "113.4" "132.6" "121.9" "120.2" "112.4" "" "" "" "" "" "" "" "" "" "" "96.6" "101.5" "81.6" "87.3" "123.4" "96.8" "112.5" "88.3" "81.1" "112.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "577500699946211837" "False" "High" "IsMasterProtein" "Q8NFQ8" "Torsin-1A-interacting protein 2 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1" "0.000" "False" "7.671" "2" "1" "2" "1" "470" "51.2" "4.96" "7.74" "1" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf05609, Pf20443" "163590" "ENSG00000169905" "TOR1AIP2" "hsa:163590; Q8NFQ8" "" "" "0" "0" "0.832" "1.885" "0.893" "1.020" "1.612" "0.899" "0.953" "1.696" "0.786" "89.2" "74.2" "168.2" "79.7" "91.1" "143.9" "80.2" "85.0" "151.3" "70.1" "" "" "" "" "" "" "" "" "" "" "80.5" "57.2" "130.1" "53.7" "76.0" "122.8" "68.0" "61.5" "102.0" "70.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-411341991637906360" "False" "High" "IsMasterProtein" "P27448" "MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5" "0.000" "False" "7.660" "3" "2" "2" "2" "753" "84.4" "9.57" "6.39" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "4140" "ENSG00000075413" "MARK3" "A0A0A0MQR8; A0A0A0MST9; A0A0A0MT23; hsa:4140; O60219; P27448; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34" "Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "Complement system in neuronal development and plasticity" "10" "0" "0.920" "0.949" "0.901" "0.919" "0.930" "0.922" "0.979" "0.956" "1.417" "159.3" "146.5" "151.1" "143.5" "146.4" "148.1" "146.9" "155.9" "152.3" "225.6" "" "" "" "" "" "" "" "" "" "" "143.8" "113.0" "116.8" "96.6" "122.1" "126.4" "124.6" "112.8" "102.7" "225.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9196998486354008360" "False" "High" "IsMasterProtein" "Q6F5E8" "Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2" "0.000" "False" "7.658" "2" "2" "2" "2" "1435" "154.6" "6.76" "6.75" "2" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13516, Pf16000, Pf17888" "146206" "ENSG00000159753" "CARMIL2" "B8X2Z3; hsa:146206; Q6F5E8" "" "" "0" "0" "0.998" "1.489" "1.020" "1.033" "1.437" "0.903" "0.788" "1.442" "1.937" "183.1" "182.8" "272.5" "186.8" "189.2" "263.1" "165.4" "144.3" "263.9" "354.6" "" "" "" "" "" "" "" "" "" "" "165.2" "141.0" "210.8" "125.8" "157.8" "224.6" "140.3" "104.4" "178.0" "354.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7796576881168078978" "False" "High" "IsMasterProtein" "Q9P2R6" "Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens OX=9606 GN=RERE PE=1 SV=2" "0.000" "False" "7.648" "1" "2" "2" "1" "1566" "172.3" "7.69" "6.74" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf01426, Pf01448, Pf03154" "473" "ENSG00000142599" "RERE" "hsa:473; O43393; O75046; O75359; Q5VXL9; Q6P6B9; Q9P2R6; Q9Y2W4" "" "" "0" "0" "0.960" "1.718" "0.985" "1.095" "1.587" "0.941" "1.020" "1.727" "0.919" "87.0" "83.5" "149.5" "85.7" "95.3" "138.0" "81.9" "88.7" "150.3" "79.9" "" "" "" "" "" "" "" "" "" "" "78.5" "64.4" "115.6" "57.7" "79.5" "117.8" "69.5" "64.2" "101.4" "79.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6388610480367959150" "False" "High" "IsMasterProtein" "O15446" "DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=POLR1G PE=1 SV=1" "0.000" "False" "7.644" "9" "3" "3" "3" "510" "55.0" "8.51" "9.01" "3" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf08208" "10849" "ENSG00000117877" "POLR1G" "hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "2q13 copy number variation syndrome" "6" "0" "1.078" "1.240" "1.063" "0.977" "1.228" "1.055" "1.089" "1.281" "0.664" "183.2" "197.5" "227.3" "194.7" "179.1" "225.0" "193.4" "199.6" "234.8" "121.6" "" "" "" "" "" "" "" "" "" "" "165.4" "152.4" "175.8" "131.1" "149.4" "192.1" "164.1" "144.4" "158.4" "121.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429984818239481220" "False" "High" "IsMasterProtein" "O60488" "Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2" "0.000" "False" "7.642" "3" "2" "3" "2" "711" "79.1" "8.38" "6.70" "2" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00501" "2182" "ENSG00000068366" "ACSL4" "D3DUY2; hsa:2182; O60488; O60848; O60849; Q5JWV8" "Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5007041047885357347" "False" "High" "IsMasterProtein" "Q15417" "Calponin-3 OS=Homo sapiens OX=9606 GN=CNN3 PE=1 SV=1" "0.000" "False" "7.637" "7" "2" "2" "1" "329" "36.4" "6.05" "4.10" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00307, Pf00402" "1266" "ENSG00000117519" "CNN3" "B4DFK6; B4DP09; F8WA86; hsa:1266; Q15417; Q6FHA7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8230923864296422238" "False" "High" "IsMasterProtein" "Q9Y303" "N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2" "0.000" "False" "7.635" "5" "2" "3" "2" "409" "43.7" "6.70" "9.24" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "51005" "ENSG00000162066" "AMDHD2" "B4DL77; hsa:51005; Q8WV54; Q9Y303" "Synthesis of UDP-N-acetyl-glucosamine" "" "1" "0" "1.054" "0.950" "1.075" "0.988" "1.115" "0.984" "0.950" "1.194" "0.787" "108.7" "114.5" "103.2" "116.9" "107.4" "121.2" "106.9" "103.3" "129.7" "85.5" "" "" "" "" "" "" "" "" "" "" "98.1" "88.3" "79.8" "78.7" "89.6" "103.4" "90.7" "74.8" "87.5" "85.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5951829502980748262" "False" "High" "IsMasterProtein" "Q92989" "Polyribonucleotide 5'-hydroxyl-kinase Clp1 OS=Homo sapiens OX=9606 GN=CLP1 PE=1 SV=1" "0.000" "False" "7.618" "6" "3" "3" "3" "425" "47.6" "6.62" "8.39" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06807, Pf16573, Pf16575" "10978" "ENSG00000172409" "CLP1" "B2R7J6; B4DTI8; hsa:10978; Q92989" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "mRNA processing" "6" "0" "1.049" "1.750" "1.065" "1.080" "2.137" "1.026" "0.823" "2.105" "2.567" "175.6" "184.2" "307.4" "187.1" "189.8" "375.3" "180.2" "144.5" "369.7" "450.9" "" "" "" "" "" "" "" "" "" "" "158.5" "142.1" "237.8" "126.0" "158.3" "320.3" "152.9" "104.6" "249.4" "450.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289825156273590713" "False" "High" "IsMasterProtein" "Q5JTV8" "Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1 PE=1 SV=2" "0.000" "False" "7.603" "3" "2" "2" "2" "583" "66.2" "8.18" "6.68" "2" "cell organization and biogenesis;other biological processes" "other membranes;nucleus" "cytoskeletal activity;other molecular function" "Pf05609, Pf20443" "26092" "ENSG00000143337" "TOR1AIP1" "A0A0A0MSK5; A8K630; B0QZ57; hsa:26092; Q5JTV6; Q5JTV8; Q8IZ65; Q9H8Y6; Q9HAJ1; Q9NV52; Q9Y3X5" "RHOF GTPase cycle; RHOD GTPase cycle" "Influence of laminopathies on Wnt signaling" "3" "0" "1.082" "1.239" "0.977" "1.477" "1.566" "0.968" "1.265" "1.052" "0.529" "59.3" "64.2" "73.5" "58.0" "87.7" "92.9" "57.4" "75.1" "62.4" "31.4" "" "" "" "" "" "" "" "" "" "" "53.6" "49.5" "56.9" "39.0" "73.1" "79.3" "48.7" "54.3" "42.1" "31.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3735327687387277491" "False" "High" "IsMasterProtein" "Q16254" "Transcription factor E2F4 OS=Homo sapiens OX=9606 GN=E2F4 PE=1 SV=2" "0.000" "False" "7.598" "5" "2" "2" "2" "413" "43.9" "4.75" "6.77" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1874" "ENSG00000205250" "E2F4" "A6NGR8; B5BU56; hsa:1874; Q12991; Q15328; Q16254" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; Alstrom syndrome" "14" "0" "0.938" "0.697" "1.115" "1.156" "0.908" "0.945" "1.178" "0.999" "1.830" "44.3" "41.6" "30.9" "49.5" "51.3" "40.3" "41.9" "52.2" "44.3" "81.2" "" "" "" "" "" "" "" "" "" "" "40.0" "32.1" "23.9" "33.3" "42.8" "34.4" "35.6" "37.8" "29.9" "81.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "727638957837399757" "False" "High" "IsMasterProtein" "O15014" "Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2" "0.000" "False" "7.592" "2" "3" "4" "3" "1411" "151.1" "8.03" "11.15" "3" "other biological processes" "nucleus" "other molecular function" "" "23060" "ENSG00000180357" "ZNF609" "hsa:23060; O15014; Q0D2I2" "" "" "0" "0" "1.024" "0.975" "1.102" "1.008" "0.975" "1.070" "1.005" "1.003" "1.388" "113.9" "116.7" "111.0" "125.5" "114.8" "111.1" "121.9" "114.5" "114.2" "158.1" "" "" "" "" "" "" "" "" "" "" "102.8" "90.0" "85.9" "84.5" "95.8" "94.8" "103.4" "82.9" "77.0" "158.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4999747194437679436" "False" "High" "IsMasterProtein" "Q969M7" "NEDD8-conjugating enzyme UBE2F OS=Homo sapiens OX=9606 GN=UBE2F PE=1 SV=1" "0.000" "False" "7.582" "12" "2" "2" "2" "185" "21.1" "6.79" "6.85" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "140739" "ENSG00000184182" "UBE2F" "A8K1Z8; B4DDT9; B4DFI1; B4DMK3; B4DZU2; B8ZZG2; C9J212; H9KVB9; Q969M7" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2q37 copy number variation syndrome" "3" "0" "1.263" "0.830" "1.150" "1.040" "1.136" "1.116" "1.063" "0.991" "0.554" "21.2" "26.8" "17.6" "24.3" "22.0" "24.1" "23.6" "22.5" "21.0" "11.7" "" "" "" "" "" "" "" "" "" "" "19.1" "20.6" "13.6" "16.4" "18.4" "20.5" "20.1" "16.3" "14.2" "11.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "718795190937465911" "False" "High" "IsMasterProtein" "Q9Y6V7" "Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1" "0.000" "False" "7.581" "4" "2" "2" "2" "483" "54.2" "9.06" "6.76" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "54555" "ENSG00000105671" "DDX49" "E7ENA0; hsa:54555; Q53FJ1; Q9BVQ8; Q9Y6V7" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869941848494998165" "False" "High" "IsMasterProtein" "O75170" "Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP6R2 PE=1 SV=2" "0.000" "False" "7.581" "3" "2" "3" "2" "966" "104.9" "4.87" "4.73" "2" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04499" "9701" "ENSG00000100239" "PPP6R2" "A6PVG3; B7Z7T3; hsa:9701; O75170; Q5U5P3; Q7Z2L2; Q7Z5G5; Q7Z731; Q9UGB9" "" "" "0" "0" "0.890" "0.855" "1.029" "0.975" "0.800" "0.665" "0.865" "1.022" "0.700" "18.8" "16.7" "16.1" "19.4" "18.4" "15.1" "12.5" "16.3" "19.2" "13.2" "" "" "" "" "" "" "" "" "" "" "17.0" "12.9" "12.4" "13.0" "15.3" "12.8" "10.6" "11.8" "13.0" "13.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186240485352530352" "False" "High" "IsMasterProtein" "Q96SI1" "BTB/POZ domain-containing protein KCTD15 OS=Homo sapiens OX=9606 GN=KCTD15 PE=1 SV=1" "0.000" "False" "7.580" "12" "4" "4" "4" "283" "31.9" "7.44" "10.18" "4" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf02214, Pf20871" "79047" "ENSG00000153885" "KCTD15" "A8K600; hsa:79047; Q96SI1; Q9BVI6" "Negative regulation of activity of TFAP2 (AP-2) family transcription factors" "" "1" "0" "1.136" "0.832" "1.383" "1.148" "1.124" "1.184" "1.277" "1.199" "1.062" "38.0" "43.1" "31.6" "52.5" "43.6" "42.7" "44.9" "48.5" "45.5" "40.3" "" "" "" "" "" "" "" "" "" "" "34.3" "33.3" "24.4" "35.3" "36.4" "36.4" "38.1" "35.1" "30.7" "40.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5424828533558395863" "False" "High" "IsMasterProtein" "O95352" "Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1" "0.000" "False" "7.578" "4" "3" "3" "3" "703" "77.9" "6.24" "9.33" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00899, Pf16420" "10533" "ENSG00000197548" "ATG7" "B4E170; E9PB95; hsa:10533; O95352; Q7L8L0; Q9BWP2; Q9UFH4" "Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy" "Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; Primary ovarian insufficiency; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "12" "0" "1.009" "0.854" "1.047" "1.067" "0.943" "1.077" "1.032" "0.888" "1.004" "129.3" "130.4" "110.4" "135.4" "137.9" "121.9" "139.2" "133.4" "114.8" "129.8" "" "" "" "" "" "" "" "" "" "" "116.7" "100.6" "85.4" "91.2" "115.1" "104.0" "118.1" "96.5" "77.4" "129.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2632668230264232030" "False" "High" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "0.000" "False" "7.576" "20" "2" "4" "1" "79" "9.7" "8.94" "13.25" "2" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "Small cell lung cancer" "3" "0" "1.167" "1.021" "1.305" "1.301" "1.169" "1.334" "1.230" "1.301" "1.245" "41.0" "47.9" "41.9" "53.5" "53.4" "48.0" "54.7" "50.5" "53.4" "51.1" "" "" "" "" "" "" "" "" "" "" "37.0" "36.9" "32.4" "36.1" "44.5" "40.9" "46.4" "36.5" "36.0" "51.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543040224215837261" "False" "High" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "0.000" "False" "7.567" "8" "2" "3" "2" "203" "23.8" "9.26" "9.34" "2" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "1.004" "0.980" "1.023" "1.092" "1.021" "1.035" "1.063" "1.018" "1.209" "326.6" "327.9" "320.2" "334.0" "356.6" "333.4" "337.9" "347.2" "332.4" "394.7" "" "" "" "" "" "" "" "" "" "" "294.8" "252.9" "247.6" "224.9" "297.5" "284.5" "286.6" "251.3" "224.2" "394.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752338987200815694" "False" "High" "IsMasterProtein" "Q9NQT4" "Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1" "0.000" "False" "7.566" "10" "2" "3" "2" "235" "25.2" "7.59" "11.82" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "56915" "ENSG00000077348" "EXOSC5" "hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8588470506095453677" "False" "High" "IsMasterProtein" "P21912" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" "0.000" "False" "7.559" "6" "2" "3" "2" "280" "31.6" "8.76" "10.78" "2" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf13085, Pf13534" "6390" "ENSG00000117118" "SDHB" "B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)" "7" "0" "1.009" "1.142" "1.068" "0.976" "1.090" "1.023" "1.055" "1.148" "0.932" "265.7" "268.1" "303.6" "283.7" "259.5" "289.7" "272.0" "280.3" "305.0" "247.7" "" "" "" "" "" "" "" "" "" "" "239.9" "206.8" "234.8" "191.1" "216.4" "247.3" "230.7" "202.9" "205.7" "247.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421733537835387635" "False" "High" "IsMasterProtein" "Q9NPE2" "Neugrin OS=Homo sapiens OX=9606 GN=NGRN PE=1 SV=2" "0.000" "False" "7.552" "7" "2" "4" "2" "291" "32.4" "9.10" "13.72" "2" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf06413" "51335" "ENSG00000182768" "NGRN" "B2R6M8; hsa:51335; Q4V9L7; Q9HBL4; Q9NPE2" "" "" "0" "0" "0.964" "0.988" "0.909" "0.988" "0.954" "0.953" "1.067" "1.036" "0.760" "460.2" "443.7" "454.8" "418.4" "454.7" "439.0" "438.5" "491.2" "477.0" "349.5" "" "" "" "" "" "" "" "" "" "" "415.4" "342.3" "351.8" "281.8" "379.3" "374.7" "372.0" "355.4" "321.7" "349.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8791134701989231462" "False" "High" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "0.000" "False" "7.549" "5" "4" "5" "4" "582" "64.8" "8.46" "12.01" "4" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "6" "0" "0.957" "1.194" "1.021" "1.224" "1.053" "1.000" "0.888" "1.334" "0.835" "56.9" "54.4" "67.9" "58.1" "69.6" "59.9" "56.8" "50.5" "75.9" "47.5" "" "" "" "" "" "" "" "" "" "" "51.3" "42.0" "52.5" "39.1" "58.1" "51.1" "48.2" "36.5" "51.2" "47.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361850666082059512" "False" "High" "IsMasterProtein" "P54252" "Ataxin-3 OS=Homo sapiens OX=9606 GN=ATXN3 PE=1 SV=5" "0.000" "False" "7.546" "6" "1" "1" "1" "361" "41.2" "4.78" "5.07" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02099, Pf02809, Pf16619" "4287" "ENSG00000066427" "ATXN3" "A7LFZ5; D6RDL9; E9PB63; hsa:4287; O15284; O15285; O15286; P54252; Q8N189; Q96TC3; Q96TC4; Q9H3N0" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Josephin domain DUBs" "HDAC6 interactions in the central nervous system" "3" "0" "1.025" "1.117" "1.416" "1.065" "1.051" "1.060" "0.852" "1.186" "1.102" "36.6" "37.5" "40.9" "51.8" "39.0" "38.5" "38.8" "31.2" "43.4" "40.3" "" "" "" "" "" "" "" "" "" "" "33.0" "28.9" "31.6" "34.9" "32.5" "32.8" "32.9" "22.6" "29.3" "40.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3150532128508731386" "False" "High" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "0.000" "False" "7.537" "9" "3" "4" "3" "376" "42.5" "5.57" "9.94" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "mRNA Splicing - Major Pathway" "" "1" "0" "0.918" "1.054" "1.086" "0.798" "1.098" "0.959" "1.032" "1.196" "0.847" "94.7" "86.9" "99.8" "102.8" "75.5" "103.9" "90.8" "97.7" "113.2" "80.2" "" "" "" "" "" "" "" "" "" "" "85.5" "67.0" "77.2" "69.2" "63.0" "88.7" "77.0" "70.7" "76.3" "80.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2488299377452803712" "False" "High" "IsMasterProtein" "Q8N9T8" "Protein KRI1 homolog OS=Homo sapiens OX=9606 GN=KRI1 PE=1 SV=3" "0.000" "False" "7.536" "4" "2" "3" "2" "703" "82.5" "5.14" "5.32" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05178, Pf12936" "65095" "ENSG00000129347" "KRI1" "hsa:65095; Q2M1R5; Q2M1R7; Q7L5J7; Q8N9T8; Q96G92; Q9BU50; Q9H6I1; Q9H978" "" "" "0" "0" "0.990" "2.333" "1.375" "0.887" "2.323" "0.930" "0.921" "2.622" "1.269" "91.1" "90.2" "212.6" "125.3" "80.9" "211.7" "84.7" "83.9" "238.9" "115.6" "" "" "" "" "" "" "" "" "" "" "82.3" "69.6" "164.4" "84.4" "67.5" "180.7" "71.9" "60.7" "161.2" "115.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446725702153589765" "False" "High" "IsMasterProtein" "Q9Y2T2" "AP-3 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP3M1 PE=1 SV=1" "0.000" "False" "7.535" "7" "2" "2" "2" "418" "46.9" "6.93" "4.96" "2" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "26985" "ENSG00000185009" "AP3M1" "hsa:26985; Q5JQ12; Q9H5L2; Q9Y2T2" "Association of TriC/CCT with target proteins during biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5029706333006790084" "False" "High" "IsMasterProtein" "Q5VT52" "Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1" "0.000" "False" "7.526" "2" "3" "3" "3" "1461" "155.9" "7.42" "7.55" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818" "23248" "ENSG00000163125" "RPRD2" "A8K6N8; B3KPT1; B4E2Q6; hsa:23248; O75048; Q5VT51; Q5VT52; Q5VT53; Q6MZL4; Q86XD2; Q9P0D7" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.053" "1.457" "1.248" "1.136" "1.456" "1.056" "1.096" "1.328" "2.283" "109.4" "115.2" "159.3" "136.5" "124.3" "159.2" "115.5" "119.9" "145.2" "249.7" "" "" "" "" "" "" "" "" "" "" "98.7" "88.8" "123.2" "91.9" "103.7" "135.9" "98.0" "86.7" "97.9" "249.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249380285139605434" "False" "High" "IsMasterProtein" "Q96CB9" "5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2" "0.000" "False" "7.523" "8" "3" "3" "3" "384" "43.1" "8.18" "8.63" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01189" "387338" "ENSG00000117481" "NSUN4" "A8K6S6; B3KQ50; B4DHA4; hsa:387338; Q5TDF7; Q96AN8; Q96CB9; Q9HAJ8" "rRNA modification in the mitochondrion" "" "1" "0" "1.041" "0.948" "0.991" "1.082" "0.946" "1.309" "1.206" "0.938" "0.984" "45.5" "47.4" "43.2" "45.1" "49.3" "43.1" "59.6" "54.9" "42.7" "44.8" "" "" "" "" "" "" "" "" "" "" "41.1" "36.6" "33.4" "30.4" "41.1" "36.8" "50.5" "39.7" "28.8" "44.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201932136610495476" "False" "High" "IsMasterProtein" "Q8NHL6" "Leukocyte immunoglobulin-like receptor subfamily B member 1 OS=Homo sapiens OX=9606 GN=LILRB1 PE=1 SV=1" "0.000" "False" "7.520" "3" "2" "2" "2" "650" "70.8" "6.05" "6.06" "2" "cell cycle OR cell proliferation;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00047, Pf13895" "10859" "ENSG00000274669; ENSG00000277807" "LILRB1" "A2IXV4; A8MXT0; hsa:10859; O75024; O75025; Q8NHJ9; Q8NHK0; Q8NHL6" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "1" "0" "0.948" "0.767" "0.923" "0.909" "0.936" "1.020" "1.069" "0.919" "0.825" "61.8" "58.6" "47.4" "57.1" "56.2" "57.9" "63.0" "66.1" "56.8" "51.0" "" "" "" "" "" "" "" "" "" "" "55.8" "45.2" "36.7" "38.4" "46.9" "49.4" "53.5" "47.8" "38.3" "51.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-348929784632102448" "False" "High" "IsMasterProtein" "O75306" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2" "0.000" "False" "7.498" "6" "2" "2" "2" "463" "52.5" "7.55" "8.04" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00346" "4720" "ENSG00000158864" "NDUFS2" "D3DVG7; hsa:4720; J3KPM7; O75306; Q5VTW0; Q969P3; Q9UEV3" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.967" "1.046" "1.317" "1.458" "0.789" "1.281" "1.056" "1.104" "1.332" "17.3" "16.7" "18.1" "22.7" "25.2" "13.6" "22.1" "18.2" "19.1" "23.0" "" "" "" "" "" "" "" "" "" "" "15.6" "12.9" "14.0" "15.3" "21.0" "11.6" "18.8" "13.2" "12.9" "23.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "173468840260374204" "False" "High" "IsMasterProtein" "Q86WB0" "Zinc finger C3HC-type protein 1 OS=Homo sapiens OX=9606 GN=ZC3HC1 PE=1 SV=1" "0.000" "False" "7.496" "3" "1" "1" "1" "502" "55.2" "5.62" "4.87" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf07967, Pf08600" "51530" "ENSG00000091732" "ZC3HC1" "A6NH66; hsa:51530; Q75MF3; Q75MF4; Q86WB0; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0" "Nuclear events stimulated by ALK signaling in cancer" "" "1" "0" "1.038" "1.592" "0.992" "0.910" "1.502" "0.883" "0.891" "1.587" "2.766" "77.6" "80.6" "123.5" "77.0" "70.6" "116.5" "68.5" "69.1" "123.1" "214.6" "" "" "" "" "" "" "" "" "" "" "70.0" "62.1" "95.5" "51.8" "58.9" "99.4" "58.1" "50.0" "83.0" "214.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2602489287625283403" "False" "High" "IsMasterProtein" "P62330" "ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2" "0.000" "False" "7.496" "12" "2" "2" "2" "175" "20.1" "8.95" "4.79" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00025" "382" "ENSG00000165527" "ARF6" "hsa:382; P26438; P62330; Q6FGZ2" "Clathrin-mediated endocytosis; TBC/RABGAPs; MET receptor recycling" "VEGFA-VEGFR2 signaling; Ras signaling; EGF/EGFR signaling pathway; IL-18 signaling pathway; Insulin signaling; CCL18 signaling pathway; 2q13 copy number variation syndrome" "10" "0" "0.925" "0.789" "0.957" "0.909" "0.888" "1.120" "0.929" "0.764" "0.681" "86.1" "79.7" "68.0" "82.4" "78.3" "76.5" "96.5" "80.0" "65.8" "58.6" "" "" "" "" "" "" "" "" "" "" "77.7" "61.5" "52.6" "55.5" "65.3" "65.3" "81.9" "57.9" "44.4" "58.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-448736336253279631" "False" "High" "IsMasterProtein" "Q9Y2H0" "Disks large-associated protein 4 OS=Homo sapiens OX=9606 GN=DLGAP4 PE=1 SV=3" "0.000" "False" "7.488" "2" "1" "1" "1" "992" "107.9" "7.08" "4.33" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf03359" "22839" "ENSG00000080845" "DLGAP4" "E1P5T5; hsa:22839; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; Q9Y2H0" "Neurexins and neuroligins" "" "1" "0" "1.169" "0.787" "1.133" "1.205" "0.822" "1.055" "1.145" "1.066" "0.864" "71.6" "83.7" "56.4" "81.1" "86.3" "58.9" "75.6" "82.0" "76.4" "61.8" "" "" "" "" "" "" "" "" "" "" "64.6" "64.6" "43.6" "54.6" "72.0" "50.3" "64.1" "59.4" "51.5" "61.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764282473727919069" "False" "High" "IsMasterProtein" "Q96K17" "Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1" "0.000" "False" "7.483" "16" "3" "4" "2" "158" "17.3" "6.35" "10.83" "3" "" "" "" "Pf01849" "91408" "ENSG00000134717" "BTF3L4" "B3KNJ1; D3DQ32; G3V1C6; hsa:91408; Q96K17" "" "" "0" "0" "0.962" "0.939" "1.151" "1.081" "0.912" "0.948" "1.017" "0.947" "0.741" "206.0" "198.1" "193.4" "237.2" "222.7" "187.9" "195.3" "209.4" "195.2" "152.8" "" "" "" "" "" "" "" "" "" "" "186.0" "152.8" "149.6" "159.7" "185.8" "160.4" "165.7" "151.6" "131.6" "152.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4160171774517724011" "False" "High" "IsMasterProtein" "P51452" "Dual specificity protein phosphatase 3 OS=Homo sapiens OX=9606 GN=DUSP3 PE=1 SV=1" "0.000" "False" "7.481" "14" "2" "2" "2" "185" "20.5" "7.80" "5.23" "2" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00782" "1845" "ENSG00000108861" "DUSP3" "D3DX45; hsa:1845; P51452; Q5U0J1; Q8IYJ9" "ERKs are inactivated" "MAPK signaling pathway; Fragile X syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187719389386559931" "False" "High" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "0.000" "False" "7.469" "13" "2" "3" "2" "147" "15.9" "8.21" "11.15" "2" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "0.951" "0.687" "0.816" "0.886" "0.703" "0.868" "0.999" "0.652" "0.669" "756.4" "719.4" "519.4" "617.3" "670.2" "531.6" "656.8" "756.0" "493.1" "506.1" "" "" "" "" "" "" "" "" "" "" "682.8" "554.9" "401.7" "415.7" "559.1" "453.7" "557.1" "547.1" "332.6" "506.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691749111498675631" "False" "High" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "0.000" "False" "7.467" "3" "1" "2" "1" "572" "61.8" "7.09" "7.60" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "CRMPs in Sema3A signaling" "" "1" "0" "1.080" "1.006" "1.002" "1.109" "1.092" "1.076" "1.075" "0.898" "0.832" "142.9" "154.3" "143.7" "143.1" "158.4" "156.1" "153.7" "153.6" "128.2" "118.9" "" "" "" "" "" "" "" "" "" "" "129.0" "119.0" "111.1" "96.4" "132.2" "133.2" "130.4" "111.1" "86.5" "118.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4300221756741418571" "False" "High" "IsMasterProtein" "P59768" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 OS=Homo sapiens OX=9606 GN=GNG2 PE=1 SV=2" "0.000" "False" "7.462" "23" "1" "3" "1" "71" "7.8" "7.99" "8.60" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "54331" "ENSG00000186469" "GNG2" "hsa:54331; P59768; Q5JPE2; Q6P9A9" "G alpha (s) signalling events; G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "36" "0" "0.867" "1.162" "1.173" "0.947" "0.747" "1.389" "1.155" "1.426" "0.897" "20.4" "17.7" "23.7" "23.9" "19.3" "15.2" "28.3" "23.5" "29.0" "18.3" "" "" "" "" "" "" "" "" "" "" "18.4" "13.6" "18.3" "16.1" "16.1" "13.0" "24.0" "17.0" "19.6" "18.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1734934898581359440" "False" "High" "IsMasterProtein" "P61457" "Pterin-4-alpha-carbinolamine dehydratase OS=Homo sapiens OX=9606 GN=PCBD1 PE=1 SV=2" "0.000" "False" "7.436" "24" "3" "4" "2" "104" "12.0" "6.80" "12.80" "3" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01329" "5092" "ENSG00000166228" "PCBD1" "hsa:5092; P61457; P70519; P80095; Q9D930" "Phenylalanine metabolism" "" "1" "0" "0.860" "1.016" "1.139" "0.939" "0.911" "0.950" "1.014" "1.089" "0.707" "86.8" "74.6" "88.2" "98.8" "81.5" "79.1" "82.4" "88.0" "94.5" "61.4" "" "" "" "" "" "" "" "" "" "" "78.3" "57.6" "68.2" "66.5" "68.0" "67.5" "69.9" "63.7" "63.7" "61.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479844659917987073" "False" "High" "IsMasterProtein" "Q9NQ48" "Leucine zipper transcription factor-like protein 1 OS=Homo sapiens OX=9606 GN=LZTFL1 PE=1 SV=1" "0.000" "False" "7.431" "7" "2" "2" "2" "299" "34.6" "5.36" "5.60" "2" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15294" "54585" "ENSG00000163818" "LZTFL1" "B3KSI9; B4E0K7; hsa:54585; Q8TC61; Q9NQ48; Q9NQ56" "BBSome-mediated cargo-targeting to cilium" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "5" "0" "1.153" "1.222" "1.584" "1.531" "1.524" "0.911" "0.822" "1.234" "0.987" "17.5" "20.1" "21.3" "27.7" "26.7" "26.6" "15.9" "14.4" "21.5" "17.2" "" "" "" "" "" "" "" "" "" "" "15.8" "15.5" "16.5" "18.6" "22.3" "22.7" "13.5" "10.4" "14.5" "17.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5558995711693310036" "False" "High" "IsMasterProtein" "Q9BWW4" "Single-stranded DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=SSBP3 PE=1 SV=1" "0.000" "False" "7.423" "5" "2" "3" "1" "388" "40.4" "6.90" "7.87" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04503" "23648" "ENSG00000157216" "SSBP3" "A8K0A9; hsa:23648; Q5T860; Q5T861; Q9BTM0; Q9BWW3; Q9BWW4" "" "" "0" "1" "0.979" "0.871" "1.033" "1.031" "0.840" "1.020" "1.044" "0.819" "0.811" "178.6" "174.8" "155.6" "184.6" "184.2" "150.0" "182.1" "186.5" "146.3" "144.8" "" "" "" "" "" "" "" "" "" "" "161.2" "134.8" "120.3" "124.3" "153.7" "128.1" "154.5" "135.0" "98.7" "144.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6865133109964514058" "False" "High" "IsMasterProtein" "Q9NVS2" "Large ribosomal subunit protein mL66 OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1" "0.000" "False" "7.419" "13" "3" "4" "3" "196" "22.2" "10.33" "12.41" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01084" "55168" "ENSG00000096080" "MRPS18A" "A6XND3; hsa:55168; Q5QPA4; Q9NVS2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.039" "0.873" "0.988" "1.058" "0.843" "0.943" "0.987" "0.958" "0.919" "443.6" "461.0" "387.3" "438.2" "469.3" "374.0" "418.5" "437.6" "424.8" "407.8" "" "" "" "" "" "" "" "" "" "" "400.4" "355.6" "299.6" "295.1" "391.5" "319.2" "355.0" "316.7" "286.5" "407.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140378452823337742" "False" "High" "IsMasterProtein" "Q9HCN4" "GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1" "0.000" "False" "7.411" "3" "1" "1" "1" "374" "41.7" "4.92" "4.44" "1" "" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03029" "11321" "ENSG00000198522" "GPN1" "B4DQJ5; B4DQM4; B4DXU4; B5MBZ5; hsa:11321; O76004; Q9HCN4" "" "" "0" "0" "1.138" "0.948" "1.083" "0.938" "0.996" "1.101" "1.075" "1.017" "0.773" "127.7" "145.4" "121.0" "138.3" "119.8" "127.3" "140.6" "137.3" "129.8" "98.7" "" "" "" "" "" "" "" "" "" "" "115.3" "112.1" "93.6" "93.1" "100.0" "108.6" "119.3" "99.4" "87.6" "98.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8869464350434744721" "False" "High" "IsMasterProtein" "O95372" "Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1" "0.000" "False" "7.404" "10" "3" "5" "3" "231" "24.7" "7.23" "14.38" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "11313" "ENSG00000011009" "LYPLA2" "hsa:11313; O95372; Q7Z4Z2" "L1CAM interactions" "" "1" "0" "1.104" "1.096" "1.054" "0.990" "0.988" "1.050" "1.102" "1.027" "0.884" "140.5" "155.1" "154.0" "148.1" "139.1" "138.8" "147.6" "154.9" "144.3" "124.3" "" "" "" "" "" "" "" "" "" "" "126.9" "119.6" "119.1" "99.7" "116.0" "118.5" "125.2" "112.1" "97.3" "124.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3711449830735196489" "False" "High" "IsMasterProtein" "Q9BZJ0" "Crooked neck-like protein 1 OS=Homo sapiens OX=9606 GN=CRNKL1 PE=1 SV=4" "0.000" "False" "7.404" "1" "1" "1" "1" "848" "100.4" "8.00" "4.07" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf02184" "51340" "ENSG00000101343" "CRNKL1" "A8K9T4; hsa:51340; Q5JY64; Q8WYI5; Q9BZI9; Q9BZJ0; Q9BZJ1; Q9BZJ2; Q9GZW7; Q9H8F8; Q9NQH5; Q9NYD8" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4022376780209334762" "False" "High" "IsMasterProtein" "Q96EM0" "Trans-3-hydroxy-L-proline dehydratase OS=Homo sapiens OX=9606 GN=L3HYPDH PE=1 SV=2" "0.000" "False" "7.396" "7" "2" "2" "2" "354" "38.1" "6.68" "7.06" "2" "" "" "other molecular function" "Pf05544" "112849" "ENSG00000126790" "L3HYPDH" "hsa:112849; Q96EM0; Q96LJ5" "" "" "0" "0" "1.156" "0.688" "1.133" "1.024" "0.984" "0.987" "0.995" "1.082" "0.881" "24.8" "28.7" "17.1" "28.1" "25.4" "24.5" "24.5" "24.7" "26.9" "21.9" "" "" "" "" "" "" "" "" "" "" "22.4" "22.2" "13.2" "18.9" "21.2" "20.9" "20.8" "17.9" "18.1" "21.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7618289525843205014" "False" "High" "IsMasterProtein" "Q7L8W6" "Diphthine--ammonia ligase OS=Homo sapiens OX=9606 GN=DPH6 PE=1 SV=3" "0.000" "False" "7.395" "9" "2" "2" "2" "267" "30.3" "5.40" "7.36" "2" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01902" "89978" "ENSG00000134146" "DPH6" "B3KWG1; hsa:89978; Q7L8W6; Q96HJ6" "Synthesis of diphthamide-EEF2" "" "1" "0" "0.923" "0.830" "1.204" "0.950" "0.727" "1.064" "1.091" "0.853" "1.251" "98.0" "90.5" "81.3" "118.0" "93.0" "71.3" "104.3" "106.9" "83.6" "122.6" "" "" "" "" "" "" "" "" "" "" "88.5" "69.8" "62.9" "79.5" "77.6" "60.8" "88.5" "77.4" "56.4" "122.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7727085808198553563" "False" "High" "IsMasterProtein" "P30291" "Wee1-like protein kinase OS=Homo sapiens OX=9606 GN=WEE1 PE=1 SV=2" "0.000" "False" "7.393" "3" "2" "2" "2" "646" "71.6" "6.77" "6.07" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7465" "ENSG00000166483" "WEE1" "B3KVE1; D3DQV0; hsa:7465; P30291" "Factors involved in megakaryocyte development and platelet production; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Cyclin A/B1/B2 associated events during G2/M transition; Polo-like kinase mediated events; G2/M DNA replication checkpoint; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control" "11" "0" "0.964" "0.794" "1.013" "0.909" "0.749" "0.928" "0.972" "0.865" "1.150" "107.3" "103.4" "85.2" "108.7" "97.5" "80.4" "99.5" "104.3" "92.8" "123.3" "" "" "" "" "" "" "" "" "" "" "96.8" "79.8" "65.9" "73.2" "81.3" "68.6" "84.4" "75.5" "62.6" "123.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2592776449693665757" "False" "High" "IsMasterProtein" "O95455" "dTDP-D-glucose 4,6-dehydratase OS=Homo sapiens OX=9606 GN=TGDS PE=1 SV=1" "0.000" "False" "7.389" "7" "2" "2" "2" "350" "40.2" "6.60" "6.51" "2" "other metabolic processes" "" "other molecular function" "Pf16363" "23483" "ENSG00000088451" "TGDS" "hsa:23483; O95455; Q05DQ3; Q2TU31; Q5T3Z2; Q9H1T9" "" "" "0" "0" "1.062" "0.980" "0.975" "1.035" "0.935" "0.986" "0.973" "0.939" "0.865" "119.9" "127.3" "117.4" "116.9" "124.0" "112.0" "118.2" "116.6" "112.6" "103.7" "" "" "" "" "" "" "" "" "" "" "108.2" "98.2" "90.8" "78.7" "103.4" "95.6" "100.2" "84.4" "75.9" "103.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669899273063133091" "False" "High" "IsMasterProtein" "Q9H3G5" "Probable serine carboxypeptidase CPVL OS=Homo sapiens OX=9606 GN=CPVL PE=1 SV=2" "0.000" "False" "7.376" "4" "2" "2" "2" "476" "54.1" "5.62" "7.09" "2" "protein metabolism" "" "other molecular function" "Pf00450" "54504" "ENSG00000106066" "CPVL" "A4D1A4; hsa:54504; Q6UX20; Q8NBL7; Q96AR7; Q9H3G5; Q9HB41" "" "" "0" "0" "1.147" "1.185" "0.985" "1.164" "1.351" "1.059" "1.079" "1.331" "0.816" "180.6" "207.1" "214.0" "177.8" "210.1" "243.9" "191.1" "194.8" "240.4" "147.3" "" "" "" "" "" "" "" "" "" "" "163.0" "159.7" "165.5" "119.7" "175.3" "208.1" "162.1" "141.0" "162.1" "147.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5711081481514943927" "False" "High" "IsMasterProtein" "P07858" "Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3" "0.000" "False" "7.372" "5" "1" "1" "1" "339" "37.8" "6.30" "4.77" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112, Pf08127" "1508" "ENSG00000164733; ENSG00000285132" "CTSB" "B3KQR5; B3KRR5; hsa:1508; P07858; Q503A6; Q96D87" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR" "Ebola virus infection in host; 8p23.1 copy number variation syndrome" "7" "0" "1.198" "1.167" "1.321" "1.266" "1.038" "1.142" "1.097" "1.382" "1.105" "39.7" "47.5" "46.3" "52.4" "50.3" "41.2" "45.3" "43.5" "54.9" "43.8" "" "" "" "" "" "" "" "" "" "" "35.8" "36.7" "35.8" "35.3" "41.9" "35.2" "38.4" "31.5" "37.0" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8041398226355410347" "False" "High" "IsMasterProtein" "Q9NUL5" "Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2" "0.000" "False" "7.362" "6" "2" "2" "2" "291" "33.1" "7.25" "4.15" "2" "stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf15135" "55337" "ENSG00000130813" "SHFL" "A8MQT9; hsa:55337; Q4G188; Q8IYH6; Q8N8V1; Q9NUL5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6060199477949358472" "False" "High" "IsMasterProtein" "Q9Y6X5" "Bis(5'-adenosyl)-triphosphatase ENPP4 OS=Homo sapiens OX=9606 GN=ENPP4 PE=1 SV=3" "0.000" "False" "7.332" "7" "3" "3" "3" "453" "51.6" "6.15" "7.14" "3" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf01663" "22875" "ENSG00000001561" "ENPP4" "A8K5G1; hsa:22875; Q7L2N1; Q9Y6X5" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1360420814074918380" "False" "High" "IsMasterProtein" "Q5T653" "Large ribosomal subunit protein uL2m OS=Homo sapiens OX=9606 GN=MRPL2 PE=1 SV=2" "0.000" "False" "7.310" "6" "2" "2" "2" "305" "33.3" "11.30" "6.83" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00181, Pf03947" "51069" "ENSG00000112651" "MRPL2" "B2RC56; hsa:51069; Q5T653; Q8WUL1; Q96Q56; Q9Y311" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.062" "0.782" "0.993" "0.987" "0.895" "0.995" "0.949" "0.845" "0.834" "177.0" "187.9" "138.4" "175.8" "174.6" "158.5" "176.1" "168.0" "149.5" "147.7" "" "" "" "" "" "" "" "" "" "" "159.8" "144.9" "107.0" "118.4" "145.7" "135.3" "149.4" "121.6" "100.9" "147.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7101780835120275737" "False" "High" "IsMasterProtein" "Q9Y3Q8" "TSC22 domain family protein 4 OS=Homo sapiens OX=9606 GN=TSC22D4 PE=1 SV=2" "0.000" "False" "7.295" "5" "2" "3" "2" "395" "41.0" "7.21" "5.40" "2" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf01166" "81628" "ENSG00000166925" "TSC22D4" "A4D2C3; A8MWR6; D6W5V9; hsa:81628; Q9Y3Q8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1438891196455375570" "False" "High" "IsMasterProtein" "A9UHW6" "MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1" "0.000" "False" "7.285" "13" "3" "3" "3" "222" "25.4" "5.33" "8.86" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854" "57409" "ENSG00000125457" "MIF4GD" "A9UHW6; B4DUM7; hsa:57409; Q8N4Q5; Q9HBL5" "" "" "0" "0" "0.986" "1.062" "1.049" "1.033" "1.057" "0.945" "0.998" "0.987" "0.835" "368.6" "363.5" "391.6" "386.7" "380.9" "389.5" "348.4" "368.0" "364.0" "307.8" "" "" "" "" "" "" "" "" "" "" "332.8" "280.4" "302.8" "260.4" "317.7" "332.4" "295.5" "266.3" "245.5" "307.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6484824469682462574" "False" "High" "IsMasterProtein" "Q17R31" "Putative deoxyribonuclease TATDN3 OS=Homo sapiens OX=9606 GN=TATDN3 PE=1 SV=1" "0.000" "False" "7.280" "8" "2" "2" "2" "274" "30.3" "7.15" "3.39" "2" "" "nucleus" "other molecular function" "Pf01026" "128387" "ENSG00000203705" "TATDN3" "A6NGS3; B7Z1C1; B7Z978; B7ZLQ6; E9PJE5; E9PNH3; G3V151; hsa:128387; Q17R31; Q4G0L1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627020223265262766" "False" "High" "IsMasterProtein" "Q8N0W3" "L-fucose kinase OS=Homo sapiens OX=9606 GN=FCSK PE=1 SV=2" "0.000" "False" "7.273" "2" "2" "2" "2" "1084" "117.5" "6.25" "6.24" "2" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf07959, Pf08544" "197258" "ENSG00000157353" "FCSK" "hsa:197258; Q5PSM3; Q5XKL6; Q6ZRA0; Q8N0W3; Q96MT9" "GDP-fucose biosynthesis" "" "1" "0" "1.066" "0.866" "1.095" "1.027" "1.009" "1.003" "0.883" "0.983" "0.715" "106.6" "113.7" "92.4" "116.8" "109.5" "107.6" "107.0" "94.2" "104.9" "76.2" "" "" "" "" "" "" "" "" "" "" "96.2" "87.7" "71.4" "78.6" "91.3" "91.8" "90.7" "68.1" "70.7" "76.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4718319405373936898" "False" "High" "IsMasterProtein" "Q5TA45" "Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2" "0.000" "False" "7.266" "3" "2" "2" "2" "600" "67.6" "8.06" "6.21" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07521, Pf10996, Pf16661, Pf21386" "54973" "ENSG00000127054" "INTS11" "A8K5S2; B3KPR3; B4DM87; G3V1S5; hsa:54973; Q5TA45; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "0.919" "0.842" "1.118" "1.120" "0.828" "1.081" "1.041" "0.989" "0.882" "109.0" "100.2" "91.8" "122.0" "122.1" "90.2" "117.9" "113.5" "107.8" "96.2" "" "" "" "" "" "" "" "" "" "" "98.4" "77.3" "71.0" "82.1" "101.9" "77.0" "100.0" "82.2" "72.7" "96.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6888861531159930886" "False" "High" "IsMasterProtein" "Q9H832" "Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2" "0.000" "False" "7.259" "10" "3" "3" "3" "354" "38.2" "5.62" "5.44" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00179" "65264" "ENSG00000159202" "UBE2Z" "A6N8M6; A6NC60; hsa:65264; Q7L354; Q8TCM4; Q9H832; Q9H893" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "" "2" "0" "1.035" "1.058" "0.997" "1.016" "1.008" "0.956" "0.902" "0.882" "0.562" "156.8" "162.3" "165.8" "156.3" "159.3" "158.1" "149.8" "141.4" "138.3" "88.1" "" "" "" "" "" "" "" "" "" "" "141.5" "125.2" "128.3" "105.2" "132.9" "134.9" "127.1" "102.4" "93.3" "88.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1597744866915900932" "False" "High" "IsMasterProtein" "P51114" "RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "0.000" "False" "7.252" "4" "2" "2" "2" "621" "69.7" "6.15" "6.22" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Signaling by BRAF and RAF1 fusions" "Bile acids synthesis and enterohepatic circulation" "2" "0" "1.102" "0.774" "1.087" "0.853" "0.771" "0.934" "0.668" "0.833" "3.969" "13.5" "14.9" "10.4" "14.7" "11.5" "10.4" "12.6" "9.0" "11.2" "53.5" "" "" "" "" "" "" "" "" "" "" "12.2" "11.5" "8.1" "9.9" "9.6" "8.9" "10.7" "6.5" "7.6" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755213045612558311" "False" "High" "IsMasterProtein" "P53367" "Arfaptin-1 OS=Homo sapiens OX=9606 GN=ARFIP1 PE=1 SV=2" "0.000" "False" "7.250" "8" "3" "4" "2" "373" "41.7" "6.70" "8.09" "3" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf06456" "27236" "ENSG00000164144" "ARFIP1" "B4DS69; hsa:27236; P53367; Q2M2X4; Q3SYL4; Q9Y2X6" "" "" "0" "1" "0.986" "1.034" "1.009" "0.797" "0.957" "0.918" "0.801" "1.107" "1.188" "295.9" "291.8" "305.9" "298.5" "235.7" "283.1" "271.6" "236.9" "327.4" "351.4" "" "" "" "" "" "" "" "" "" "" "267.1" "225.1" "236.6" "201.0" "196.6" "241.7" "230.4" "171.4" "220.9" "351.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893746772392115503" "False" "High" "IsMasterProtein" "Q6P1L5" "Protein FAM117B OS=Homo sapiens OX=9606 GN=FAM117B PE=1 SV=2" "0.000" "False" "7.244" "4" "2" "2" "2" "589" "61.9" "9.82" "6.41" "2" "" "" "" "Pf15388" "150864" "ENSG00000138439" "FAM117B" "hsa:150864; Q53QZ5; Q585T9; Q6P1L5; Q8N8W1; Q96Q34" "" "" "0" "0" "0.986" "0.774" "1.065" "0.923" "0.789" "0.938" "0.867" "0.854" "1.014" "219.3" "216.3" "169.8" "233.5" "202.3" "173.0" "205.7" "190.1" "187.3" "222.4" "" "" "" "" "" "" "" "" "" "" "197.9" "166.8" "131.3" "157.2" "168.7" "147.6" "174.5" "137.6" "126.3" "222.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8005883181375695291" "False" "High" "IsMasterProtein" "Q9P260" "RAB11-binding protein RELCH OS=Homo sapiens OX=9606 GN=RELCH PE=1 SV=2" "0.000" "False" "7.244" "1" "1" "2" "1" "1216" "134.5" "5.45" "6.11" "1" "transport" "ER/Golgi;other cytoplasmic organelle" "" "" "57614" "ENSG00000134444" "RELCH" "hsa:57614; Q9P260" "" "" "0" "0" "0.792" "1.329" "1.106" "1.021" "1.312" "0.944" "0.878" "1.314" "1.902" "78.5" "62.2" "104.4" "86.9" "80.2" "103.1" "74.2" "69.0" "103.1" "149.3" "" "" "" "" "" "" "" "" "" "" "70.9" "48.0" "80.7" "58.5" "66.9" "88.0" "62.9" "49.9" "69.6" "149.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4572306403840384650" "False" "High" "IsMasterProtein" "O75208" "Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1" "0.000" "False" "7.229" "5" "2" "3" "2" "318" "35.5" "5.94" "9.45" "2" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08511, Pf21392" "57017" "ENSG00000088682" "COQ9" "A8K3L2; hsa:57017; O75208; Q7L5V7; Q7Z5T6; Q8NBL4; Q9NTJ2; Q9P056" "Ubiquinol biosynthesis" "" "1" "0" "1.173" "1.017" "1.084" "1.146" "0.861" "1.158" "1.002" "1.064" "0.913" "116.3" "136.4" "118.3" "126.0" "133.3" "100.1" "134.6" "116.5" "123.7" "106.2" "" "" "" "" "" "" "" "" "" "" "105.0" "105.2" "91.5" "84.8" "111.2" "85.4" "114.2" "84.3" "83.5" "106.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472433998448837783" "False" "High" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "0.000" "False" "7.223" "8" "3" "4" "3" "286" "33.7" "9.36" "11.76" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "RHOJ GTPase cycle; RHOH GTPase cycle" "" "2" "0" "1.041" "0.921" "0.939" "1.038" "1.023" "1.001" "0.955" "0.996" "0.752" "405.5" "422.2" "373.4" "380.6" "420.7" "414.9" "405.8" "387.3" "403.9" "305.1" "" "" "" "" "" "" "" "" "" "" "366.0" "325.7" "288.8" "256.3" "350.9" "354.1" "344.2" "280.3" "272.4" "305.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8392578490847645683" "False" "High" "IsMasterProtein" "Q9NR33" "DNA polymerase epsilon subunit 4 OS=Homo sapiens OX=9606 GN=POLE4 PE=1 SV=2" "0.000" "False" "7.211" "21" "1" "2" "1" "117" "12.2" "4.92" "7.38" "1" "DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "56655" "ENSG00000115350" "POLE4" "Q53TR2; Q9NR33" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "786541619406263347" "False" "High" "IsMasterProtein" "O95243" "Methyl-CpG-binding domain protein 4 OS=Homo sapiens OX=9606 GN=MBD4 PE=1 SV=1" "0.000" "False" "7.209" "2" "1" "1" "1" "580" "66.0" "8.82" "4.13" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01429" "8930" "ENSG00000129071" "MBD4" "B4DZN2; D3DNC3; D3DNC4; E9PEE4; hsa:8930; O95243; Q2MD36; Q7Z4T3; Q96F09" "Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1" "Base excision repair; DNA repair pathways, full network" "5" "0" "0.926" "0.958" "1.022" "0.949" "0.910" "0.923" "0.993" "0.900" "1.679" "119.1" "110.3" "114.2" "121.7" "113.0" "108.3" "109.9" "118.3" "107.2" "199.9" "" "" "" "" "" "" "" "" "" "" "107.5" "85.1" "88.3" "81.9" "94.3" "92.5" "93.3" "85.6" "72.3" "199.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9152525013652249776" "False" "High" "IsMasterProtein" "Q9H999" "Pantothenate kinase 3 OS=Homo sapiens OX=9606 GN=PANK3 PE=1 SV=1" "0.000" "False" "7.200" "8" "3" "4" "1" "370" "41.1" "6.55" "10.89" "3" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf03630" "79646" "ENSG00000120137" "PANK3" "D3DQL1; hsa:79646; Q53FJ9; Q7RTX4; Q9H999" "Coenzyme A biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8286175184294444153" "False" "High" "IsMasterProtein" "A0AAG2TVC3" "Uncharacterized protein OS=Homo sapiens OX=9606 PE=4 SV=1" "0.000" "False" "7.188" "9" "2" "2" "1" "264" "28.0" "4.67" "4.51" "2" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4149430532130191750" "False" "High" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "0.000" "False" "7.188" "4" "2" "2" "2" "564" "62.3" "6.99" "3.73" "2" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Coenzyme A biosynthesis" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6631585726403495176" "False" "High" "IsMasterProtein" "O14787" "Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2 PE=1 SV=3" "0.000" "False" "7.172" "2" "2" "3" "1" "897" "101.3" "5.01" "5.48" "2" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf03810" "30000" "ENSG00000105576" "TNPO2" "hsa:30000; O14655; O14787; Q6IN77" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8306155883597695001" "False" "High" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "0.000" "False" "7.160" "8" "2" "3" "2" "273" "29.3" "8.18" "8.14" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "Ion transport by P-type ATPases" "" "1" "0" "0.987" "1.190" "0.950" "0.932" "1.055" "1.008" "1.163" "1.133" "0.891" "37.3" "36.8" "44.4" "35.4" "34.8" "39.4" "37.6" "43.4" "42.3" "33.3" "" "" "" "" "" "" "" "" "" "" "33.7" "28.4" "34.3" "23.9" "29.0" "33.6" "31.9" "31.4" "28.5" "33.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6395227692188504005" "False" "High" "IsMasterProtein" "Q7Z3K3" "Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2" "0.000" "False" "7.156" "2" "2" "2" "2" "1410" "155.2" "7.40" "2.75" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03184, Pf03221" "23126" "ENSG00000143442" "POGZ" "B4DTP8; B4DYL9; B7ZBY5; E9PM80; hsa:23126; O75049; Q3LIC4; Q5SZS1; Q5SZS2; Q5SZS3; Q5SZS4; Q7Z3K3; Q8TDZ7; Q9Y4X7" "" "" "0" "0" "1.173" "1.892" "1.006" "1.496" "2.236" "1.486" "0.710" "2.635" "2.030" "12.1" "14.2" "22.9" "12.2" "18.1" "27.1" "18.0" "8.6" "32.0" "24.6" "" "" "" "" "" "" "" "" "" "" "10.9" "11.0" "17.7" "8.2" "15.1" "23.1" "15.3" "6.2" "21.6" "24.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4231086194268643311" "False" "High" "IsMasterProtein" "Q8N6R0" "eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=METTL13 PE=1 SV=1" "0.000" "False" "7.144" "3" "3" "3" "3" "699" "78.7" "6.73" "8.54" "3" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01564, Pf13847" "51603" "ENSG00000010165" "METTL13" "A6NFK0; A8K6S5; hsa:51603; O94940; Q53EZ6; Q5TGP9; Q5TGQ0; Q8N2P8; Q8N6R0; Q96J11; Q96SQ0; Q9Y2Z1; Q9Y3M6" "" "" "0" "0" "0.937" "0.896" "1.151" "1.128" "0.765" "1.111" "0.747" "0.968" "4.274" "410.9" "385.0" "368.1" "473.0" "463.5" "314.4" "456.4" "306.9" "397.5" "1755.9" "" "" "" "" "" "" "" "" "" "" "370.9" "297.0" "284.7" "318.5" "386.6" "268.4" "387.2" "222.1" "268.1" "1755.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-771583783129928248" "False" "High" "IsMasterProtein" "P35869" "Aryl hydrocarbon receptor OS=Homo sapiens OX=9606 GN=AHR PE=1 SV=2" "0.000" "False" "7.141" "2" "2" "2" "2" "848" "96.1" "6.38" "6.55" "2" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf08447" "196" "ENSG00000106546" "AHR" "A4D130; hsa:196; P35869; Q13728; Q13803; Q13804" "PPARA activates gene expression; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling" "Adipogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Cannabinoid receptor signaling; Development and heterogeneity of the ILC family; Male infertility; Prostaglandin signaling; Th17 cell differentiation pathway" "14" "0" "1.263" "1.002" "1.537" "1.604" "1.149" "1.331" "1.049" "1.348" "2.607" "50.0" "63.1" "50.1" "76.8" "80.2" "57.4" "66.5" "52.4" "67.4" "130.2" "" "" "" "" "" "" "" "" "" "" "45.1" "48.7" "38.7" "51.7" "66.9" "49.0" "56.4" "37.9" "45.4" "130.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1239746035430338710" "False" "High" "IsMasterProtein" "Q2T9J0" "Peroxisomal leader peptide-processing protease OS=Homo sapiens OX=9606 GN=TYSND1 PE=1 SV=3" "0.000" "False" "7.136" "2" "1" "1" "1" "566" "59.3" "6.20" "4.09" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf13365" "219743" "ENSG00000156521" "TYSND1" "hsa:219743; Q2T9J0; Q5SQT4; Q5SQU1; Q8N6H2; Q96AR5" "TYSND1 cleaves peroxisomal proteins" "" "2" "0" "1.013" "0.800" "1.061" "1.098" "0.709" "1.128" "0.928" "0.838" "0.696" "77.2" "78.2" "61.8" "81.9" "84.8" "54.7" "87.2" "71.7" "64.7" "53.8" "" "" "" "" "" "" "" "" "" "" "69.7" "60.4" "47.8" "55.2" "70.7" "46.7" "73.9" "51.9" "43.7" "53.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6920554993800994285" "False" "High" "IsMasterProtein" "Q02880" "DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3" "0.000" "False" "7.122" "1" "1" "1" "1" "1626" "183.2" "8.00" "3.68" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7155" "ENSG00000077097" "TOP2B" "hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8" "SUMOylation of DNA replication proteins" "" "1" "0" "1.007" "3.487" "0.856" "1.350" "3.536" "1.415" "0.997" "3.809" "1.741" "10.1" "10.2" "35.3" "8.7" "13.7" "35.8" "14.3" "10.1" "38.5" "17.6" "" "" "" "" "" "" "" "" "" "" "9.1" "7.9" "27.3" "5.8" "11.4" "30.5" "12.1" "7.3" "26.0" "17.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747450166338589829" "False" "High" "IsMasterProtein" "Q8IUE6" "Histone H2A type 2-B OS=Homo sapiens OX=9606 GN=H2AC21 PE=1 SV=3" "0.000" "False" "7.116" "18" "3" "8" "1" "130" "14.0" "10.89" "20.80" "3" "" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "317772" "ENSG00000184270" "H2AC21" "hsa:317772; Q8IUE6" "HCMV Late Events; UCH proteinases; Ub-specific processing proteases; HCMV Early Events; HDACs deacetylate histones; Metalloprotease DUBs; RMTs methylate histone arginines; HATs acetylate histones" "" "8" "0" "1.556" "1.737" "0.481" "1.566" "1.466" "1.384" "1.607" "0.986" "1.265" "17.9" "27.8" "31.1" "8.6" "28.0" "26.2" "24.8" "28.7" "17.6" "22.6" "" "" "" "" "" "" "" "" "" "" "16.2" "21.5" "24.0" "5.8" "23.4" "22.4" "21.0" "20.8" "11.9" "22.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3805240560895531655" "False" "High" "IsMasterProtein" "Q15532" "Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3" "0.000" "False" "7.111" "2" "1" "2" "1" "418" "45.9" "6.46" "6.60" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05030" "6760" "ENSG00000141380" "SS18" "B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6" "" "" "0" "0" "0.859" "0.994" "1.021" "0.885" "0.966" "0.992" "0.890" "1.137" "1.220" "66.8" "57.4" "66.4" "68.2" "59.1" "64.5" "66.3" "59.5" "75.9" "81.5" "" "" "" "" "" "" "" "" "" "" "60.3" "44.3" "51.3" "45.9" "49.3" "55.1" "56.2" "43.0" "51.2" "81.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547321454778217727" "False" "High" "IsMasterProtein" "Q6PID6" "Tetratricopeptide repeat protein 33 OS=Homo sapiens OX=9606 GN=TTC33 PE=1 SV=2" "0.000" "False" "7.103" "4" "1" "2" "1" "262" "29.4" "5.44" "7.14" "1" "" "" "" "" "23548" "ENSG00000113638" "TTC33" "B2R6G0; hsa:23548; O95105; Q6PID6" "" "" "0" "0" "0.923" "0.948" "0.893" "1.022" "0.945" "0.987" "0.885" "1.008" "1.753" "167.4" "154.5" "158.7" "149.6" "171.2" "158.1" "165.3" "148.2" "168.8" "293.4" "" "" "" "" "" "" "" "" "" "" "151.1" "119.2" "122.7" "100.7" "142.8" "135.0" "140.2" "107.3" "113.8" "293.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-319216844392798796" "False" "High" "IsMasterProtein" "Q9Y4R8" "Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2" "0.000" "False" "7.098" "3" "2" "2" "2" "837" "91.7" "5.76" "5.32" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10193" "9894" "ENSG00000100726" "TELO2" "D3DU73; hsa:9894; O75168; Q7LDV4; Q9BR21; Q9Y4R8" "" "Fragile X syndrome; Pleural mesothelioma" "2" "0" "0.888" "0.680" "0.830" "0.696" "0.787" "0.915" "0.705" "0.739" "4.269" "99.5" "88.4" "67.7" "82.6" "69.2" "78.3" "91.1" "70.2" "73.5" "424.9" "" "" "" "" "" "" "" "" "" "" "89.8" "68.2" "52.3" "55.6" "57.8" "66.8" "77.3" "50.8" "49.6" "424.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407060077554528043" "False" "High" "IsMasterProtein" "Q5T3I0" "G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2" "0.000" "False" "7.097" "4" "2" "3" "2" "446" "50.4" "9.63" "8.72" "2" "" "nucleus" "" "Pf01585" "" "ENSG00000292251" "GPATCH4" "Q5T3I0; Q5T3I1; Q6ZUE7; Q8IWG8; Q9NXH4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5405439584537602890" "False" "High" "IsMasterProtein" "Q9BX46" "RNA-binding protein 24 OS=Homo sapiens OX=9606 GN=RBM24 PE=1 SV=1" "0.000" "False" "7.092" "8" "2" "3" "2" "236" "24.8" "8.51" "7.56" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "221662" "ENSG00000112183" "RBM24" "E9PAY4; hsa:221662; Q6QDA4; Q8N9D3; Q96NI3; Q9BX46" "" "" "0" "0" "0.939" "0.878" "1.094" "1.050" "0.982" "1.104" "1.073" "0.869" "0.754" "204.6" "192.2" "179.7" "223.9" "214.9" "201.0" "225.9" "219.6" "177.8" "154.3" "" "" "" "" "" "" "" "" "" "" "184.7" "148.2" "139.0" "150.8" "179.2" "171.5" "191.6" "158.9" "119.9" "154.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "282539810863181563" "False" "High" "IsMasterProtein" "Q9UL40" "Zinc finger protein 346 OS=Homo sapiens OX=9606 GN=ZNF346 PE=1 SV=1" "0.000" "False" "7.078" "4" "1" "3" "1" "294" "32.9" "9.09" "7.80" "1" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "23567" "ENSG00000113761" "ZNF346" "B7Z367; hsa:23567; Q68CV9; Q6ZMW1; Q9UL40" "" "5q35 copy number variation" "1" "0" "1.232" "1.070" "0.998" "0.885" "1.043" "1.185" "0.927" "1.079" "0.897" "17.6" "21.8" "18.9" "17.6" "15.6" "18.4" "20.9" "16.4" "19.0" "15.8" "" "" "" "" "" "" "" "" "" "" "15.9" "16.8" "14.6" "11.9" "13.0" "15.7" "17.7" "11.8" "12.8" "15.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8712581138028706155" "False" "High" "IsMasterProtein" "Cont_P02081" "Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1" "0.000" "True" "7.062" "8" "1" "1" "1" "145" "15.8" "7.03" "4.48" "1" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "104983812; 109569915; 109569938; 511735" "ENSBIXG00000000751; ENSBTAG00000038748" "LOC104983812; LOC109569915; LOC113905586" "A0A4W2CHH0; A0A6P3GXP4; A0A6P5D2L1; bbis:104983812; biu:109569915; biu:109569938; bta:511735; P02081; Q3SX09" "" "" "0" "0" "0.885" "0.933" "1.019" "0.757" "0.991" "0.861" "0.853" "1.093" "0.595" "129.4" "114.5" "120.7" "131.9" "97.9" "128.3" "111.4" "110.5" "141.5" "77.0" "" "" "" "" "" "" "" "" "" "" "116.8" "88.3" "93.4" "88.9" "81.7" "109.5" "94.5" "79.9" "95.4" "77.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787023427386069087" "False" "High" "IsMasterProtein" "P53365" "Arfaptin-2 OS=Homo sapiens OX=9606 GN=ARFIP2 PE=1 SV=1" "0.000" "False" "7.060" "5" "2" "2" "1" "341" "37.8" "6.04" "5.99" "2" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06456" "23647" "ENSG00000132254" "ARFIP2" "B4DX86; B4E306; D3DQT5; hsa:23647; P53365" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.844" "0.679" "0.854" "0.869" "0.674" "0.892" "0.922" "0.688" "0.996" "74.2" "62.7" "50.4" "63.4" "64.5" "50.0" "66.2" "68.4" "51.1" "73.9" "" "" "" "" "" "" "" "" "" "" "67.0" "48.3" "39.0" "42.7" "53.8" "42.7" "56.2" "49.5" "34.5" "73.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2198906581928094734" "False" "High" "IsMasterProtein" "Q9BQC3" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1" "0.000" "False" "7.050" "5" "2" "3" "2" "489" "52.1" "5.53" "9.90" "2" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01866" "1802" "ENSG00000132768" "DPH2" "A8MVC9; B2RDE3; B4DNI8; hsa:1802; O60623; Q9BQC3" "Synthesis of diphthamide-EEF2" "" "1" "0" "1.152" "1.120" "1.281" "1.153" "0.818" "1.008" "0.939" "1.162" "1.109" "27.7" "32.0" "31.1" "35.5" "32.0" "22.7" "28.0" "26.1" "32.2" "30.8" "" "" "" "" "" "" "" "" "" "" "25.0" "24.7" "24.0" "23.9" "26.7" "19.4" "23.7" "18.9" "21.8" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5557556089384344895" "False" "High" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "0.000" "False" "7.044" "4" "2" "3" "2" "482" "54.1" "5.55" "8.56" "2" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032092853006601019" "False" "High" "IsMasterProtein" "Q13303" "Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2" "0.000" "False" "7.029" "4" "2" "3" "2" "367" "41.0" "9.00" "9.50" "2" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf00248" "8514" "ENSG00000069424" "KCNAB2" "A0AVM9; A8K1A4; B0AZR7; hsa:8514; O43659; Q13303; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411" "Neutrophil degranulation; Voltage gated Potassium channels" "Metapathway biotransformation Phase I and II" "3" "0" "0.973" "1.013" "1.143" "1.009" "0.969" "0.942" "0.843" "1.030" "0.721" "70.5" "68.6" "71.4" "80.5" "71.1" "68.3" "66.4" "59.4" "72.6" "50.8" "" "" "" "" "" "" "" "" "" "" "63.6" "52.9" "55.2" "54.2" "59.3" "58.3" "56.3" "43.0" "49.0" "50.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475093268658479309" "False" "High" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "0.000" "False" "7.018" "13" "2" "4" "2" "178" "20.4" "5.03" "11.38" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "" "Metapathway biotransformation Phase I and II" "1" "0" "1.047" "0.886" "1.080" "0.992" "1.019" "0.966" "1.070" "0.954" "0.770" "169.8" "177.8" "150.5" "183.4" "168.4" "173.1" "164.0" "181.7" "162.0" "130.7" "" "" "" "" "" "" "" "" "" "" "153.3" "137.1" "116.4" "123.5" "140.5" "147.7" "139.1" "131.5" "109.2" "130.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449517754761536848" "False" "High" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "0.000" "False" "7.015" "8" "2" "2" "2" "227" "26.5" "8.41" "6.88" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4707319533501773453" "False" "High" "IsMasterProtein" "O95260" "Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2" "0.000" "False" "7.015" "4" "2" "2" "2" "518" "59.1" "7.93" "6.23" "2" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04376, Pf04377" "11101" "ENSG00000107669" "ATE1" "hsa:11101; O95260; O95261; Q5SQQ3; Q8WW04" "" "" "0" "0" "0.941" "0.685" "0.941" "0.921" "0.768" "1.028" "1.082" "0.708" "0.808" "88.3" "83.1" "60.5" "83.1" "81.3" "67.8" "90.8" "95.5" "62.5" "71.3" "" "" "" "" "" "" "" "" "" "" "79.7" "64.1" "46.8" "56.0" "67.8" "57.9" "77.0" "69.1" "42.2" "71.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6070529034068729651" "False" "High" "IsMasterProtein" "Q8TEV9" "Guanine nucleotide exchange protein SMCR8 OS=Homo sapiens OX=9606 GN=SMCR8 PE=1 SV=2" "0.000" "False" "7.001" "2" "2" "3" "2" "937" "105.0" "5.58" "8.76" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11704" "140775" "ENSG00000176994; ENSG00000283741" "SMCR8" "A5PKZ5; hsa:140775; Q3ZCN0; Q6PJL3; Q8TEV9" "" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "1" "0" "1.003" "0.929" "1.122" "1.049" "0.887" "1.030" "1.005" "1.044" "0.947" "223.1" "223.9" "207.3" "250.3" "234.0" "198.0" "229.9" "224.3" "232.9" "211.3" "" "" "" "" "" "" "" "" "" "" "201.4" "172.7" "160.3" "168.5" "195.2" "169.0" "195.0" "162.3" "157.1" "211.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1353658345851562217" "False" "High" "IsMasterProtein" "Q9BR76" "Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1" "0.000" "False" "7.000" "3" "2" "3" "2" "489" "54.2" "5.88" "8.13" "2" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "57175" "ENSG00000172725" "CORO1B" "B2RD45; hsa:57175; Q9BR76" "" "" "0" "0" "0.988" "0.948" "0.884" "1.076" "0.998" "0.925" "0.855" "0.939" "1.125" "96.5" "95.4" "91.4" "85.3" "103.8" "96.3" "89.2" "82.5" "90.6" "108.5" "" "" "" "" "" "" "" "" "" "" "87.1" "73.6" "70.7" "57.4" "86.6" "82.2" "75.7" "59.7" "61.1" "108.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "717271239892975644" "False" "High" "IsMasterProtein" "Q9UK73" "Protein fem-1 homolog B OS=Homo sapiens OX=9606 GN=FEM1B PE=1 SV=1" "0.000" "False" "6.997" "4" "2" "2" "2" "627" "70.2" "6.61" "7.20" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf12796" "10116" "ENSG00000169018" "FEM1B" "hsa:10116; O43146; Q9UK73" "Neddylation" "" "1" "0" "1.007" "0.672" "0.888" "1.095" "0.758" "0.987" "1.040" "0.730" "0.669" "139.5" "140.5" "93.7" "123.9" "152.9" "105.7" "137.7" "145.1" "101.9" "93.3" "" "" "" "" "" "" "" "" "" "" "126.0" "108.4" "72.5" "83.4" "127.5" "90.2" "116.8" "105.0" "68.7" "93.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173280212815183212" "False" "High" "IsMasterProtein" "Q2M385" "Macrophage-expressed gene 1 protein OS=Homo sapiens OX=9606 GN=MPEG1 PE=1 SV=1" "0.000" "False" "6.996" "4" "3" "3" "3" "716" "78.5" "7.65" "7.65" "3" "stress response;transport;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01823" "219972" "ENSG00000197629" "MPEG1" "hsa:219972; Q2M1T6; Q2M385; Q8TEF8" "" "" "0" "0" "1.254" "1.066" "0.772" "1.182" "0.872" "1.147" "1.245" "1.054" "1.116" "44.2" "55.4" "47.1" "34.1" "52.2" "38.5" "50.7" "55.0" "46.6" "49.3" "" "" "" "" "" "" "" "" "" "" "39.9" "42.7" "36.4" "23.0" "43.6" "32.9" "43.0" "39.8" "31.4" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1811232654349558643" "False" "High" "IsMasterProtein" "P18846" "Cyclic AMP-dependent transcription factor ATF-1 OS=Homo sapiens OX=9606 GN=ATF1 PE=1 SV=2" "0.000" "False" "6.978" "9" "3" "5" "1" "271" "29.2" "8.37" "13.50" "3" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "466" "ENSG00000123268" "ATF1" "B4DRF9; hsa:466; P18846; P25168; Q9H4A8" "NGF-stimulated transcription; CREB phosphorylation" "Integrated cancer pathway; Androgen receptor network in prostate cancer; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; GDNF signaling; Serotonin receptor 4/6/7 and NR3C signaling" "9" "0" "1.131" "0.916" "0.907" "1.024" "0.913" "1.154" "1.150" "0.996" "0.747" "148.6" "168.1" "136.2" "134.9" "152.2" "135.8" "171.5" "170.9" "148.1" "111.1" "" "" "" "" "" "" "" "" "" "" "134.2" "129.7" "105.3" "90.8" "127.0" "115.9" "145.5" "123.7" "99.9" "111.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7573385717766537595" "False" "High" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "0.000" "False" "6.976" "3" "1" "1" "1" "426" "46.0" "8.53" "4.29" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "Photodynamic therapy-induced HIF-1 survival signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "5" "0" "0.913" "1.015" "1.190" "0.898" "0.890" "1.256" "0.862" "1.015" "3.132" "40.0" "36.6" "40.6" "47.6" "35.9" "35.6" "50.3" "34.5" "40.6" "125.4" "" "" "" "" "" "" "" "" "" "" "36.1" "28.2" "31.4" "32.1" "30.0" "30.4" "42.6" "25.0" "27.4" "125.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "978357741075337008" "False" "High" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "0.000" "False" "6.963" "2" "1" "1" "1" "594" "66.5" "5.59" "4.04" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "" "6" "0" "1.040" "1.272" "0.837" "0.855" "1.151" "0.772" "0.834" "0.923" "1.583" "51.1" "53.1" "65.0" "42.8" "43.7" "58.8" "39.5" "42.6" "47.2" "80.9" "" "" "" "" "" "" "" "" "" "" "46.1" "41.0" "50.3" "28.8" "36.5" "50.2" "33.5" "30.9" "31.8" "80.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6039342044264890236" "False" "High" "IsMasterProtein" "Q99808" "Equilibrative nucleoside transporter 1 OS=Homo sapiens OX=9606 GN=SLC29A1 PE=1 SV=3" "0.000" "False" "6.959" "5" "2" "2" "2" "456" "50.2" "8.29" "6.98" "2" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf01733" "2030" "ENSG00000112759" "SLC29A1" "B3KQV7; B3KQY5; hsa:2030; Q5T9W9; Q99808; Q9UJY2" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Azathioprine ADME; Ribavirin ADME" "Fluoropyrimidine activity" "4" "0" "0.838" "0.900" "0.995" "0.767" "0.768" "0.933" "0.882" "1.010" "0.935" "66.0" "55.3" "59.4" "65.7" "50.6" "50.7" "61.6" "58.2" "66.6" "61.7" "" "" "" "" "" "" "" "" "" "" "59.6" "42.7" "45.9" "44.2" "42.2" "43.3" "52.3" "42.1" "44.9" "61.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773607396615155691" "False" "High" "IsMasterProtein" "Q16774" "Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2" "0.000" "False" "6.944" "11" "2" "3" "2" "197" "21.7" "6.55" "6.18" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00625" "2987" "ENSG00000143774" "GUK1" "B1ANH1; hsa:2987; Q16774" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME" "" "2" "0" "1.127" "0.834" "1.193" "1.082" "0.863" "1.069" "0.835" "0.947" "3.023" "98.0" "110.4" "81.8" "116.9" "106.1" "84.6" "104.8" "81.8" "92.8" "296.3" "" "" "" "" "" "" "" "" "" "" "88.5" "85.2" "63.2" "78.7" "88.5" "72.2" "88.9" "59.2" "62.6" "296.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6970631393786121187" "False" "High" "IsMasterProtein" "Q8WU79" "Stromal membrane-associated protein 2 OS=Homo sapiens OX=9606 GN=SMAP2 PE=1 SV=1" "0.000" "False" "6.940" "5" "2" "2" "2" "429" "46.8" "8.87" "5.98" "2" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "64744" "ENSG00000084070" "SMAP2" "B2R7T1; B7Z5B5; B7Z8V2; D3DPV2; hsa:64744; Q5QPL2; Q8WU79; Q96C93; Q9NST2; Q9UJL8" "" "" "0" "0" "0.985" "0.883" "1.052" "0.792" "0.935" "0.807" "0.742" "0.965" "2.784" "89.2" "87.9" "78.7" "93.8" "70.6" "83.4" "72.0" "66.2" "86.0" "248.3" "" "" "" "" "" "" "" "" "" "" "80.5" "67.8" "60.9" "63.2" "58.9" "71.2" "61.1" "47.9" "58.0" "248.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557682221437211922" "False" "High" "IsMasterProtein" "Q9Y6Q9" "Nuclear receptor coactivator 3 OS=Homo sapiens OX=9606 GN=NCOA3 PE=1 SV=1" "0.000" "False" "6.938" "1" "1" "1" "1" "1424" "155.2" "7.47" "4.12" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16279, Pf16665" "8202" "ENSG00000124151" "NCOA3" "A4LAZ5; hsa:8202; Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; Q9Y6Q9" "Estrogen-dependent gene expression; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; MAPK6/MAPK4 signaling" "Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway; Rubinstein-Taybi syndrome 1" "11" "0" "1.294" "1.163" "0.898" "1.159" "0.986" "1.044" "0.924" "0.788" "0.867" "36.5" "47.3" "42.5" "32.8" "42.3" "36.0" "38.1" "33.7" "28.8" "31.7" "" "" "" "" "" "" "" "" "" "" "33.0" "36.4" "32.8" "22.1" "35.3" "30.7" "32.3" "24.4" "19.4" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1016656761563188351" "False" "High" "IsMasterProtein" "O15127" "Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2" "0.000" "False" "6.930" "6" "1" "1" "1" "329" "36.6" "6.10" "4.96" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04144" "10066" "ENSG00000140497" "SCAMP2" "B2RDF0; hsa:10066; O15127; Q9BQE8" "" "Serotonin transporter activity; Monoamine transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4353551603118957972" "False" "High" "IsMasterProtein" "P34949" "Mannose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=MPI PE=1 SV=2" "0.000" "False" "6.925" "3" "1" "2" "1" "423" "46.6" "5.95" "6.49" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01238, Pf20511, Pf20512" "4351" "ENSG00000178802" "MPI" "A8K8K9; hsa:4351; P34949; Q96AB0" "Synthesis of GDP-mannose; Defective MPI causes MPI-CDG" "N-glycan biosynthesis" "3" "0" "1.026" "1.109" "0.927" "0.986" "1.119" "0.911" "1.027" "0.908" "1.377" "133.5" "137.0" "148.0" "123.8" "131.7" "149.3" "121.6" "137.1" "121.2" "183.8" "" "" "" "" "" "" "" "" "" "" "120.5" "105.7" "114.5" "83.4" "109.8" "127.4" "103.2" "99.2" "81.7" "183.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2341580766278944773" "False" "High" "IsMasterProtein" "P15056" "Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4" "0.000" "False" "6.913" "3" "3" "3" "1" "766" "84.4" "7.53" "8.22" "3" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "673" "ENSG00000157764" "BRAF" "A4D1T4; B6HY61; B6HY62; B6HY63; B6HY64; B6HY65; B6HY66; hsa:673; P15056; Q13878; Q3MIN6; Q9UDP8; Q9Y6T3" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Spry regulation of FGF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; Signalling to p38 via RIT and RIN; Negative feedback regulation of MAPK pathway" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Polycystic kidney disease pathway; Bladder cancer; Focal adhesion; BDNF-TrkB signaling; MAPK signaling pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Rett syndrome; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; MAPK pathway in congenital thyroid cancer; TCA cycle in senescence; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; ErbB signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "56" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3673508278002205446" "False" "High" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "0.000" "False" "6.902" "4" "1" "1" "1" "298" "33.0" "9.22" "4.59" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria" "4" "0" "0.966" "1.055" "0.897" "0.922" "0.970" "1.069" "0.931" "0.833" "0.959" "123.9" "119.7" "130.6" "111.2" "114.2" "120.1" "132.4" "115.3" "103.2" "118.8" "" "" "" "" "" "" "" "" "" "" "111.8" "92.3" "101.0" "74.9" "95.2" "102.5" "112.3" "83.5" "69.6" "118.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8965718931841673636" "False" "High" "IsMasterProtein" "Q9Y496" "Kinesin-like protein KIF3A OS=Homo sapiens OX=9606 GN=KIF3A PE=1 SV=4" "0.000" "False" "6.889" "4" "2" "3" "1" "699" "80.0" "6.54" "4.85" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "11127" "ENSG00000131437" "KIF3A" "A8MSW9; hsa:11127; Q59EN1; Q86XE9; Q9Y496; Q9Y6V4" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins; Hedgehog 'off' state; Activation of SMO" "Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling" "11" "0" "1.439" "1.027" "1.410" "1.374" "1.157" "1.139" "1.249" "1.282" "1.769" "22.2" "32.0" "22.8" "31.3" "30.5" "25.7" "25.3" "27.8" "28.5" "39.3" "" "" "" "" "" "" "" "" "" "" "20.1" "24.7" "17.7" "21.1" "25.5" "22.0" "21.5" "20.1" "19.2" "39.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6803776007100694472" "False" "High" "IsMasterProtein" "P51580" "Thiopurine S-methyltransferase OS=Homo sapiens OX=9606 GN=TPMT PE=1 SV=1" "0.000" "False" "6.888" "7" "2" "3" "2" "245" "28.2" "6.23" "7.88" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf05724" "7172" "ENSG00000137364" "TPMT" "hsa:7172; O14806; O15423; O15424; O15425; O15426; O15515; O15548; O43213; P51580; Q5VUK6; Q9UBE6; Q9UBT8; Q9UE62" "Azathioprine ADME; Methylation; Defective TPMT causes TPMT deficiency" "Metapathway biotransformation Phase I and II; Methylation pathways" "5" "0" "1.154" "1.081" "1.185" "1.101" "1.111" "1.152" "1.023" "1.048" "0.815" "96.2" "111.0" "103.9" "114.0" "105.9" "106.9" "110.8" "98.4" "100.8" "78.4" "" "" "" "" "" "" "" "" "" "" "86.8" "85.6" "80.4" "76.8" "88.3" "91.2" "94.0" "71.2" "68.0" "78.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476906646827946246" "False" "High" "IsMasterProtein" "Q13315" "Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4" "0.000" "False" "6.885" "1" "3" "3" "3" "3056" "350.5" "6.81" "8.01" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf11640" "472" "ENSG00000149311" "ATM" "B2RNX5; hsa:472; O15429; Q12758; Q13315; Q16551; Q93007; Q9NP02; Q9UCX7" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Resolution of D-loop Structures through Holliday Junction Intermediates; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Degradation; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Sensing of DNA Double Strand Breaks; Pexophagy" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Homologous recombination; Glioblastoma signaling pathways; ATM signaling pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian infertility; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; ATM signaling in development and disease ; DNA IR-double strand breaks and cellular response via ATM; miRNA regulation of p53 pathway in prostate cancer; DNA IR-damage and cellular response via ATR; Breast cancer pathway; G1 to S cell cycle control; Joubert syndrome; Male infertility; DNA repair pathways, full network; Pleural mesothelioma; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome; Primary ovarian insufficiency; DNA damage response; DNA damage response (only ATM dependent)" "54" "0" "1.087" "0.878" "1.152" "1.110" "0.984" "1.064" "1.053" "0.918" "1.040" "73.5" "79.9" "64.6" "84.7" "81.6" "72.3" "78.2" "77.4" "67.5" "76.4" "" "" "" "" "" "" "" "" "" "" "66.4" "61.6" "49.9" "57.0" "68.1" "61.7" "66.4" "56.0" "45.5" "76.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400550207963658767" "False" "High" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "0.000" "False" "6.883" "5" "3" "3" "3" "499" "55.4" "5.78" "7.64" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3661455698439909776" "False" "High" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "0.000" "False" "6.870" "9" "3" "3" "3" "307" "34.9" "9.57" "9.88" "3" "signal transduction" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.896" "0.840" "0.895" "1.089" "0.997" "0.915" "1.015" "0.784" "0.710" "167.0" "149.6" "140.3" "149.6" "181.9" "166.5" "152.8" "169.5" "131.0" "118.6" "" "" "" "" "" "" "" "" "" "" "150.8" "115.4" "108.5" "100.7" "151.7" "142.1" "129.6" "122.7" "88.3" "118.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1075701088619798442" "False" "High" "IsMasterProtein" "Q96BZ8" "Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=2" "0.000" "False" "6.857" "6" "2" "2" "2" "264" "30.5" "9.80" "5.88" "2" "" "nucleus" "" "Pf10197" "79165" "ENSG00000105617; ENSG00000275935; ENSG00000276628; ENSG00000276774; ENSG00000276959; ENSG00000277457; ENSG00000277808; ENSG00000278257; ENSG00000278426; ENSG00000278516" "LENG1" "hsa:79165; Q96BZ8; Q9HCU7" "mRNA Splicing - Major Pathway" "" "1" "0" "1.112" "1.175" "1.147" "1.101" "1.316" "1.081" "1.053" "1.264" "0.784" "141.8" "157.7" "166.6" "162.6" "156.0" "186.5" "153.2" "149.3" "179.2" "111.1" "" "" "" "" "" "" "" "" "" "" "128.0" "121.6" "128.9" "109.5" "130.1" "159.2" "129.9" "108.1" "120.8" "111.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3918971924664803467" "False" "High" "IsMasterProtein" "Q14088" "Ras-related protein Rab-33A OS=Homo sapiens OX=9606 GN=RAB33A PE=1 SV=2" "0.000" "False" "6.857" "8" "2" "3" "2" "237" "26.6" "7.88" "9.57" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00071" "9363" "ENSG00000134594" "RAB33A" "hsa:9363; Q14088; Q5JUZ6; Q92465" "RAB geranylgeranylation; TBC/RABGAPs" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6591516084365101626" "False" "High" "IsMasterProtein" "Q9H5X1" "Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1" "0.000" "False" "6.848" "19" "3" "3" "3" "160" "18.3" "4.88" "8.92" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01883" "84191" "ENSG00000166797" "CIAO2A" "A6NKS1; B2R5F8; B7Z8Z5; hsa:84191; Q9H5X1" "" "2q11.2 copy number variation syndrome" "1" "0" "0.885" "0.963" "1.109" "1.159" "0.951" "0.892" "0.846" "0.974" "0.754" "118.7" "105.1" "114.4" "131.7" "137.7" "112.9" "105.9" "100.5" "115.6" "89.5" "" "" "" "" "" "" "" "" "" "" "107.2" "81.1" "88.5" "88.7" "114.8" "96.4" "89.9" "72.7" "78.0" "89.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4995074517937679177" "False" "High" "IsMasterProtein" "O95628" "CCR4-NOT transcription complex subunit 4 OS=Homo sapiens OX=9606 GN=CNOT4 PE=1 SV=3" "0.000" "False" "6.836" "5" "2" "2" "2" "575" "63.5" "7.03" "4.78" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf14570" "4850" "ENSG00000080802" "CNOT4" "B7Z6I4; E7ET38; F8VQP3; O95339; O95627; O95628; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "1.249" "1.083" "1.246" "1.037" "1.165" "1.247" "1.163" "1.287" "1.085" "41.0" "51.3" "44.5" "51.1" "42.5" "47.8" "51.2" "47.7" "52.8" "44.5" "" "" "" "" "" "" "" "" "" "" "37.0" "39.5" "34.4" "34.4" "35.5" "40.8" "43.4" "34.5" "35.6" "44.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4664768508757263066" "False" "High" "IsMasterProtein" "Q15527" "Surfeit locus protein 2 OS=Homo sapiens OX=9606 GN=SURF2 PE=1 SV=4" "0.000" "False" "6.822" "12" "2" "3" "2" "256" "29.6" "9.22" "5.30" "2" "" "plasma membrane;other membranes;nucleus" "" "Pf05477" "6835" "ENSG00000148291; ENSG00000281024" "SURF2" "hsa:6835; Q15527; Q6IBP9; Q96CD1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7751322844419777287" "False" "High" "IsMasterProtein" "P33121" "Long-chain-fatty-acid--CoA ligase 1 OS=Homo sapiens OX=9606 GN=ACSL1 PE=1 SV=1" "0.000" "False" "6.798" "3" "2" "3" "2" "698" "77.9" "7.15" "8.31" "2" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00501" "2180" "ENSG00000151726" "ACSL1" "B7Z452; D3DP57; hsa:2180; P33121; P41215; Q8N8V7; Q8TA99" "PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders; Fatty acids and lipoproteins transport in hepatocytes; Cholesterol biosynthesis pathway in hepatocytes" "17" "0" "1.207" "0.831" "1.117" "0.996" "0.861" "1.038" "1.021" "0.912" "1.065" "81.0" "97.8" "67.3" "90.5" "80.7" "69.8" "84.1" "82.7" "73.9" "86.3" "" "" "" "" "" "" "" "" "" "" "73.2" "75.5" "52.1" "61.0" "67.3" "59.6" "71.4" "59.9" "49.9" "86.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "175514539462856121" "False" "High" "IsMasterProtein" "Q9BT67" "NEDD4 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=NDFIP1 PE=1 SV=1" "0.000" "False" "6.796" "8" "2" "3" "2" "221" "24.9" "4.68" "5.73" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10176" "80762" "ENSG00000131507" "NDFIP1" "B2RDB8; D3DQF0; hsa:80762; Q658T8; Q8N2E3; Q8N2F9; Q9BT67" "" "" "0" "0" "1.030" "0.953" "1.207" "1.046" "0.877" "0.953" "1.181" "0.876" "0.551" "91.2" "93.9" "86.9" "110.1" "95.4" "80.0" "86.9" "107.7" "79.9" "50.2" "" "" "" "" "" "" "" "" "" "" "82.3" "72.4" "67.2" "74.1" "79.6" "68.3" "73.7" "77.9" "53.9" "50.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4577230366185343110" "False" "High" "IsMasterProtein" "Q96GM8" "Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1" "0.000" "False" "6.793" "6" "3" "3" "3" "510" "56.5" "7.18" "9.34" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04857" "114034" "ENSG00000132773" "TOE1" "B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846" "" "" "0" "0" "0.868" "0.911" "0.904" "0.985" "0.809" "0.826" "0.909" "0.842" "0.790" "122.8" "106.6" "111.9" "111.0" "120.9" "99.3" "101.5" "111.7" "103.5" "97.0" "" "" "" "" "" "" "" "" "" "" "110.9" "82.2" "86.5" "74.7" "100.9" "84.8" "86.1" "80.8" "69.8" "97.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781078747776304120" "False" "High" "IsMasterProtein" "Q9NY12" "H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1" "0.000" "False" "6.789" "8" "2" "2" "2" "217" "22.3" "10.92" "6.14" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf04410" "54433" "ENSG00000109534" "GAR1" "hsa:54433; Q5MJQ2; Q9NY12" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "" "2" "0" "0.698" "1.041" "1.504" "1.186" "1.058" "1.016" "0.799" "1.356" "1.255" "13.6" "9.5" "14.1" "20.4" "16.1" "14.4" "13.8" "10.9" "18.4" "17.1" "" "" "" "" "" "" "" "" "" "" "12.3" "7.3" "10.9" "13.8" "13.5" "12.3" "11.7" "7.9" "12.4" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "433749903708797592" "False" "High" "IsMasterProtein" "Q8NB46" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens OX=9606 GN=ANKRD52 PE=1 SV=3" "0.000" "False" "6.786" "2" "2" "2" "2" "1076" "115.0" "6.48" "6.09" "2" "" "" "" "Pf00023, Pf12796" "283373" "ENSG00000139645" "ANKRD52" "A6NE79; B1Q2K2; hsa:283373; Q8NB46" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2840679928359396214" "False" "High" "IsMasterProtein" "Q6P1N0" "Coiled-coil and C2 domain-containing protein 1A OS=Homo sapiens OX=9606 GN=CC2D1A PE=1 SV=1" "0.000" "False" "6.779" "3" "3" "4" "3" "951" "104.0" "8.09" "9.80" "3" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "54862" "ENSG00000132024; ENSG00000288293" "CC2D1A" "hsa:54862; Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1" "" "Sudden infant death syndrome (SIDS) susceptibility pathways" "1" "0" "1.098" "1.117" "1.344" "1.305" "1.082" "1.072" "1.009" "1.322" "1.278" "42.3" "46.4" "47.2" "56.8" "55.2" "45.7" "45.3" "42.7" "55.9" "54.1" "" "" "" "" "" "" "" "" "" "" "38.2" "35.8" "36.5" "38.3" "46.0" "39.0" "38.4" "30.9" "37.7" "54.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "706443412800658116" "False" "High" "IsMasterProtein" "O14683" "Tumor protein p53-inducible protein 11 OS=Homo sapiens OX=9606 GN=TP53I11 PE=1 SV=2" "0.000" "False" "6.769" "13" "2" "2" "2" "189" "21.0" "9.55" "7.03" "2" "other biological processes" "other membranes" "" "Pf14936" "9537" "ENSG00000175274" "TP53I11" "hsa:9537; O14683; Q3ZCS0" "" "11p11.2 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551300482488071361" "False" "High" "IsMasterProtein" "P78332" "RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5" "0.000" "False" "6.768" "2" "2" "2" "2" "1123" "128.6" "6.32" "5.71" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf17780" "10180" "ENSG00000004534" "RBM6" "B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3" "" "" "0" "0" "1.198" "1.319" "1.389" "1.179" "1.517" "0.996" "0.917" "1.424" "1.910" "55.3" "66.3" "73.0" "76.8" "65.2" "83.9" "55.1" "50.7" "78.8" "105.7" "" "" "" "" "" "" "" "" "" "" "49.9" "51.1" "56.5" "51.7" "54.4" "71.6" "46.8" "36.7" "53.1" "105.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "588939397575272440" "False" "High" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "0.000" "False" "6.765" "3" "1" "1" "1" "689" "74.3" "9.57" "4.78" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2129800861400375686" "False" "High" "IsMasterProtein" "O60220" "Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1" "0.000" "False" "6.751" "11" "1" "1" "1" "97" "11.0" "5.16" "4.36" "1" "cell organization and biogenesis;transport;developmental processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "1678" "ENSG00000126953" "TIMM8A" "B2R5A6; O60220; Q6IRW6" "Mitochondrial protein import" "" "1" "0" "0.970" "0.968" "1.236" "1.148" "1.099" "1.186" "1.287" "0.928" "0.547" "127.6" "123.8" "123.6" "157.7" "146.5" "140.2" "151.3" "164.2" "118.4" "69.8" "" "" "" "" "" "" "" "" "" "" "115.2" "95.5" "95.6" "106.2" "122.2" "119.7" "128.4" "118.8" "79.9" "69.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5145837311521029190" "False" "High" "IsMasterProtein" "Q8N183" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Homo sapiens OX=9606 GN=NDUFAF2 PE=1 SV=1" "0.000" "False" "6.750" "11" "2" "2" "2" "169" "19.8" "8.97" "5.56" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf05071" "91942" "ENSG00000164182" "NDUFAF2" "A8K5I1; hsa:91942; Q8N183" "Complex I biogenesis" "SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "2" "0" "0.997" "1.118" "0.954" "1.002" "1.121" "1.085" "1.146" "1.266" "0.602" "90.0" "89.8" "100.7" "85.9" "90.2" "100.9" "97.6" "103.1" "113.9" "54.2" "" "" "" "" "" "" "" "" "" "" "81.2" "69.2" "77.9" "57.8" "75.2" "86.1" "82.8" "74.6" "76.8" "54.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485362868972298733" "False" "High" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "0.000" "False" "6.735" "8" "1" "8" "1" "115" "12.5" "7.88" "20.14" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "Adipogenesis; Spinal cord injury; HDAC6 interactions in the central nervous system" "6" "0" "0.996" "1.116" "1.197" "1.046" "1.088" "1.178" "1.262" "1.047" "0.681" "309.5" "308.2" "345.4" "370.7" "323.7" "336.9" "364.8" "390.7" "324.1" "210.8" "" "" "" "" "" "" "" "" "" "" "279.4" "237.7" "267.1" "249.6" "270.0" "287.5" "309.4" "282.7" "218.6" "210.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1270194887050037302" "False" "High" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "0.000" "False" "6.734" "9" "3" "4" "3" "275" "30.3" "8.22" "11.94" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "Ciliary landscape" "5" "0" "0.978" "0.969" "0.915" "0.949" "0.989" "0.916" "1.004" "0.995" "0.684" "416.4" "407.4" "403.6" "381.2" "395.0" "411.7" "381.3" "418.2" "414.1" "284.7" "" "" "" "" "" "" "" "" "" "" "375.9" "314.3" "312.2" "256.7" "329.5" "351.4" "323.4" "302.7" "279.3" "284.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "115101743397248701" "False" "High" "IsMasterProtein" "Q15528" "Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2" "0.000" "False" "6.716" "9" "2" "3" "2" "200" "22.2" "4.68" "9.59" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06179" "6837" "ENSG00000148297; ENSG00000281022" "MED22" "B3KW83; B3KWX4; hsa:6837; O76072; Q15528; Q5T8U0" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "0.996" "1.065" "1.090" "0.926" "0.905" "0.874" "0.937" "0.914" "1.214" "60.8" "60.6" "64.7" "66.3" "56.3" "55.0" "53.1" "56.9" "55.5" "73.8" "" "" "" "" "" "" "" "" "" "" "54.9" "46.7" "50.1" "44.6" "46.9" "46.9" "45.1" "41.2" "37.5" "73.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5693736025540312441" "False" "High" "IsMasterProtein" "P0CG12" "Decreased expression in renal and prostate cancer protein OS=Homo sapiens OX=9606 GN=DERPC PE=1 SV=1" "0.000" "False" "6.704" "2" "1" "1" "1" "524" "51.4" "12.41" "4.11" "1" "" "nucleus" "" "" "" "ENSG00000286140" "DERPC" "A8MYX8; P0CG12; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "" "" "0" "0" "0.938" "0.825" "0.996" "1.087" "0.760" "0.966" "1.016" "0.845" "0.803" "178.7" "167.7" "147.3" "177.9" "194.3" "135.8" "172.5" "181.5" "151.0" "143.5" "" "" "" "" "" "" "" "" "" "" "161.3" "129.3" "114.0" "119.8" "162.1" "115.9" "146.4" "131.4" "101.9" "143.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6536357785872288465" "False" "High" "IsMasterProtein" "P48723" "Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1" "0.000" "False" "6.699" "3" "1" "1" "1" "471" "51.9" "5.76" "3.01" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00012" "6782" "ENSG00000155304" "HSPA13" "B2R616; hsa:6782; P48723; Q8NE40" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "1.024" "0.720" "0.947" "0.993" "0.793" "0.978" "1.008" "0.844" "1.092" "33.6" "34.4" "24.2" "31.8" "33.4" "26.7" "32.9" "33.9" "28.4" "36.7" "" "" "" "" "" "" "" "" "" "" "30.3" "26.5" "18.7" "21.4" "27.8" "22.8" "27.9" "24.5" "19.1" "36.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-397251386471415027" "False" "High" "IsMasterProtein" "Q9Y3X0" "Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1" "0.000" "False" "6.699" "3" "2" "3" "2" "531" "59.7" "5.40" "9.57" "2" "" "nucleus" "nucleic acid binding activity" "Pf15266" "26093" "ENSG00000105321" "CCDC9" "hsa:26093; Q9Y3X0" "" "IL-18 signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273003467290879098" "False" "High" "IsMasterProtein" "Q9UNE7" "E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2" "0.000" "False" "6.687" "6" "2" "2" "2" "303" "34.8" "5.87" "5.80" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf04564, Pf12895, Pf18391" "10273" "ENSG00000103266" "STUB1" "A2IDB9; O60526; Q969U2; Q9HBT1; Q9UNE7" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of TNFR1 signaling; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Downregulation of TGF-beta receptor signaling" "Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "11" "0" "0.973" "0.845" "1.077" "0.884" "0.907" "0.953" "0.538" "1.117" "5.631" "88.1" "85.7" "74.4" "94.8" "77.8" "79.9" "84.0" "47.4" "98.4" "496.0" "" "" "" "" "" "" "" "" "" "" "79.5" "66.1" "57.6" "63.9" "64.9" "68.2" "71.2" "34.3" "66.3" "496.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7586099756274293155" "False" "High" "IsMasterProtein" "Q71UM5" "Ribosomal protein eS27-like OS=Homo sapiens OX=9606 GN=RPS27L PE=1 SV=3" "0.000" "False" "6.684" "23" "2" "5" "1" "84" "9.5" "9.45" "12.94" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01667" "51065" "ENSG00000185088" "RPS27L" "hsa:51065; Q71UM5; Q9BTJ1" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "" "18" "0" "1.108" "0.986" "0.981" "1.107" "1.173" "1.073" "1.084" "0.981" "0.702" "136.0" "150.7" "134.1" "133.4" "150.6" "159.6" "145.9" "147.4" "133.4" "95.5" "" "" "" "" "" "" "" "" "" "" "122.8" "116.3" "103.7" "89.8" "125.6" "136.2" "123.7" "106.7" "90.0" "95.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5323796797448371098" "False" "High" "IsMasterProtein" "Q16520" "Basic leucine zipper transcriptional factor ATF-like OS=Homo sapiens OX=9606 GN=BATF PE=1 SV=1" "0.000" "False" "6.678" "16" "2" "2" "2" "125" "14.1" "8.75" "7.75" "2" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "10538" "ENSG00000156127" "BATF" "hsa:10538; Q16520" "Interleukin-4 and Interleukin-13 signaling" "Prion disease pathway; Cancer immunotherapy by PD-1 blockade" "3" "0" "0.891" "0.848" "0.872" "0.982" "0.837" "0.901" "0.801" "0.812" "0.777" "375.3" "334.3" "318.5" "327.4" "368.6" "314.0" "338.2" "300.8" "304.7" "291.4" "" "" "" "" "" "" "" "" "" "" "338.8" "257.9" "246.3" "220.4" "307.5" "268.0" "286.9" "217.7" "205.5" "291.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463882674882175167" "False" "High" "IsMasterProtein" "Q5NDL2" "EGF domain-specific O-linked N-acetylglucosamine transferase OS=Homo sapiens OX=9606 GN=EOGT PE=1 SV=1" "0.000" "False" "6.676" "7" "4" "4" "4" "527" "62.0" "7.05" "10.58" "4" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf04577" "285203" "ENSG00000163378" "EOGT" "A8K2U1; B4DFH5; hsa:285203; L7X1M5; Q5NDL2; Q6MZY0; Q6P985; Q6ZTV0" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "1.013" "0.987" "1.113" "1.078" "0.964" "1.056" "1.065" "1.025" "0.920" "309.6" "313.5" "305.5" "344.8" "333.7" "298.6" "326.9" "329.8" "317.4" "284.9" "" "" "" "" "" "" "" "" "" "" "279.5" "241.8" "236.3" "232.2" "278.3" "254.8" "277.3" "238.7" "214.1" "284.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076185631256904569" "False" "High" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "0.000" "False" "6.662" "8" "2" "2" "2" "225" "25.7" "9.25" "5.45" "2" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518477556068487686" "False" "High" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "0.000" "False" "6.658" "19" "3" "4" "3" "118" "12.7" "7.30" "11.11" "3" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "1.005" "1.077" "0.969" "1.040" "1.090" "0.982" "0.994" "1.155" "0.648" "424.8" "427.0" "457.4" "411.4" "442.0" "463.2" "417.3" "422.5" "490.7" "275.4" "" "" "" "" "" "" "" "" "" "" "383.5" "329.4" "353.8" "277.1" "368.7" "395.3" "354.0" "305.7" "331.0" "275.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6528342238616596443" "False" "High" "IsMasterProtein" "Q92542" "Nicastrin OS=Homo sapiens OX=9606 GN=NCSTN PE=1 SV=2" "0.000" "False" "6.653" "3" "2" "2" "2" "709" "78.4" "5.99" "6.24" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05450, Pf18266" "23385" "ENSG00000162736" "NCSTN" "hsa:23385; Q5T207; Q5T208; Q86VV5; Q92542" "Neutrophil degranulation; Amyloid fiber formation; Degradation of the extracellular matrix; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; Nuclear signaling by ERBB4; EPH-ephrin mediated repulsion of cells; NOTCH4 Activation and Transmission of Signal to the Nucleus; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; Noncanonical activation of NOTCH3" "Alzheimer's disease and miRNA effects; Notch signaling; Inclusion body myositis; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development; Notch signaling pathway" "20" "0" "0.990" "1.015" "1.254" "1.283" "1.127" "1.407" "1.252" "1.061" "0.809" "49.9" "49.4" "50.7" "62.6" "64.0" "56.3" "70.2" "62.5" "53.0" "40.4" "" "" "" "" "" "" "" "" "" "" "45.1" "38.1" "39.2" "42.2" "53.4" "48.0" "59.6" "45.2" "35.7" "40.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "487381900913570393" "False" "High" "IsMasterProtein" "Q9H8Y8" "Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3" "0.000" "False" "6.651" "6" "3" "4" "3" "452" "47.1" "4.82" "9.51" "3" "cell organization and biogenesis;stress response;other biological processes" "other membranes;ER/Golgi" "" "Pf04495" "26003" "ENSG00000115806" "GORASP2" "B4DKT0; hsa:26003; Q53TE3; Q96I74; Q96K84; Q9H8Y8; Q9H946; Q9UFW4" "Golgi Cisternae Pericentriolar Stack Reorganization" "" "1" "0" "1.601" "1.487" "1.762" "1.736" "1.475" "1.773" "0.937" "1.833" "5.192" "25.2" "40.3" "37.5" "44.4" "43.7" "37.1" "44.7" "23.6" "46.2" "130.8" "" "" "" "" "" "" "" "" "" "" "22.7" "31.1" "29.0" "29.9" "36.5" "31.7" "37.9" "17.1" "31.1" "130.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077095867447308247" "False" "High" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "0.000" "False" "6.627" "3" "1" "2" "1" "421" "46.1" "9.99" "5.45" "1" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "" "3" "0" "1.074" "1.022" "1.289" "1.021" "0.971" "1.084" "1.093" "1.167" "0.983" "66.5" "71.4" "67.9" "85.7" "67.9" "64.6" "72.0" "72.7" "77.6" "65.4" "" "" "" "" "" "" "" "" "" "" "60.0" "55.1" "52.5" "57.7" "56.6" "55.1" "61.1" "52.6" "52.3" "65.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8775799832689222428" "False" "High" "IsMasterProtein" "Q8IV38" "Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1" "0.000" "False" "6.623" "2" "1" "1" "1" "441" "49.3" "6.25" "3.51" "1" "" "other cell component" "other molecular function" "Pf01753, Pf12796" "57037" "ENSG00000106524" "ANKMY2" "A4D124; hsa:57037; Q659G1; Q8IV38; Q96BL3" "" "" "0" "0" "0.930" "0.958" "0.933" "1.065" "0.761" "1.078" "0.921" "0.872" "1.479" "117.7" "109.5" "112.8" "109.8" "125.3" "89.6" "126.9" "108.4" "102.5" "174.0" "" "" "" "" "" "" "" "" "" "" "106.2" "84.4" "87.2" "73.9" "104.5" "76.4" "107.6" "78.5" "69.2" "174.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7755566090060093643" "False" "High" "IsMasterProtein" "P35914" "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2" "0.000" "False" "6.619" "6" "2" "2" "2" "325" "34.3" "8.54" "6.50" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00682" "3155" "ENSG00000117305" "HMGCL" "B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8" "Peroxisomal protein import; Synthesis of Ketone Bodies" "Amino acid metabolism" "3" "0" "0.896" "0.998" "0.920" "0.945" "0.937" "1.044" "0.964" "1.001" "0.711" "186.4" "167.0" "186.2" "171.6" "176.1" "174.7" "194.6" "179.7" "186.7" "132.5" "" "" "" "" "" "" "" "" "" "" "168.3" "128.8" "144.0" "115.6" "146.9" "149.1" "165.1" "130.0" "125.9" "132.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1917909410339364485" "False" "High" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "0.000" "False" "6.615" "3" "3" "3" "3" "940" "99.0" "9.17" "8.83" "3" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "1.042" "1.095" "0.953" "1.003" "1.087" "1.007" "0.993" "1.094" "1.190" "430.0" "448.1" "470.9" "409.9" "431.2" "467.2" "433.1" "426.9" "470.6" "511.6" "" "" "" "" "" "" "" "" "" "" "388.1" "345.7" "364.2" "276.0" "359.7" "398.8" "367.4" "308.9" "317.4" "511.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "729714306402912246" "False" "High" "IsMasterProtein" "Q15628" "Tumor necrosis factor receptor type 1-associated DEATH domain protein OS=Homo sapiens OX=9606 GN=TRADD PE=1 SV=2" "0.000" "False" "6.603" "7" "2" "2" "2" "312" "34.2" "6.27" "5.64" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf09034" "8717" "ENSG00000102871" "TRADD" "B2RDS3; B3KQZ9; hsa:8717; Q15628; Q52NZ1" "Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling; Defective RIPK1-mediated regulated necrosis" "TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "20" "0" "0.940" "0.804" "1.494" "1.152" "0.852" "1.056" "0.584" "0.662" "5.040" "34.6" "32.6" "27.9" "51.8" "39.9" "29.5" "36.6" "20.2" "22.9" "174.6" "" "" "" "" "" "" "" "" "" "" "31.3" "25.1" "21.5" "34.8" "33.3" "25.2" "31.0" "14.6" "15.5" "174.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3530209516211162637" "False" "High" "IsMasterProtein" "Q5JRA6" "Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1" "0.000" "False" "6.598" "1" "2" "2" "2" "1907" "213.6" "4.84" "3.08" "2" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07653" "375056" "ENSG00000154305" "MIA3" "A8K2S0; A8MT05; A8MT13; B7Z430; hsa:375056; Q14083; Q3S4X3; Q5JRA5; Q5JRA6; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; Q86Y60; Q8N8M5; Q92580" "Cargo concentration in the ER; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Type I collagen synthesis in the context of osteogenesis imperfecta" "4" "0" "1.035" "1.062" "0.985" "0.900" "1.079" "0.947" "0.845" "1.146" "0.773" "179.8" "186.1" "191.0" "177.1" "161.8" "194.0" "170.3" "151.9" "206.1" "139.1" "" "" "" "" "" "" "" "" "" "" "162.3" "143.6" "147.8" "119.2" "135.0" "165.6" "144.5" "109.9" "139.0" "139.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7666744292030772641" "False" "High" "IsMasterProtein" "Q9BRK5" "45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1" "0.000" "False" "6.598" "6" "2" "2" "2" "362" "41.8" "4.86" "5.98" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "51150" "" "SDF4" "B1AME5; B1AME6; B2RDF1; B4DSM1; hsa:51150; Q53G52; Q53HQ9; Q8NBQ3; Q96AA1; Q9BRK5; Q9NZP7; Q9UN53" "" "" "0" "0" "0.983" "1.003" "1.062" "1.053" "0.906" "0.989" "0.897" "0.998" "1.432" "201.7" "198.3" "202.3" "214.1" "212.3" "182.7" "199.5" "180.9" "201.2" "288.8" "" "" "" "" "" "" "" "" "" "" "182.0" "152.9" "156.4" "144.2" "177.1" "156.0" "169.2" "130.9" "135.7" "288.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8204162643568548731" "False" "High" "IsMasterProtein" "Q9HD47" "Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1" "0.000" "False" "6.589" "7" "1" "1" "1" "186" "20.4" "4.94" "3.94" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04603" "29098" "ENSG00000108961" "RANGRF" "D3DTR6; hsa:29098; Q68DI3; Q9BR68; Q9HD47; Q9HD48; Q9NRU9; Q9P001; Q9P0P2" "Phase 0 - rapid depolarisation" "" "1" "0" "0.985" "0.738" "1.075" "0.871" "0.786" "0.767" "1.061" "0.991" "0.808" "55.5" "54.7" "41.0" "59.7" "48.4" "43.6" "42.6" "58.9" "55.0" "44.8" "" "" "" "" "" "" "" "" "" "" "50.1" "42.2" "31.7" "40.2" "40.4" "37.2" "36.1" "42.6" "37.1" "44.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5444771599092088743" "False" "High" "IsMasterProtein" "Q96EY9" "Probable inactive tRNA-specific adenosine deaminase-like protein 3 OS=Homo sapiens OX=9606 GN=ADAT3 PE=1 SV=1" "0.000" "False" "6.584" "6" "2" "3" "2" "351" "38.0" "7.88" "6.23" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00383" "113179" "" "ADAT3" "hsa:113179; Q96EY9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "1.148" "1.073" "1.357" "0.995" "1.084" "1.133" "1.038" "1.232" "0.958" "70.7" "81.1" "75.9" "96.0" "70.4" "76.6" "80.1" "73.4" "87.1" "67.7" "" "" "" "" "" "" "" "" "" "" "63.8" "62.6" "58.7" "64.6" "58.7" "65.4" "68.0" "53.1" "58.8" "67.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "213953215988823024" "False" "High" "IsMasterProtein" "Q92896" "Golgi apparatus protein 1 OS=Homo sapiens OX=9606 GN=GLG1 PE=1 SV=2" "0.000" "False" "6.579" "1" "1" "1" "1" "1179" "134.5" "6.90" "3.41" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytoskeleton;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00839" "2734" "ENSG00000090863" "GLG1" "B7Z8Y4; D3DUJ7; hsa:2734; Q13221; Q6P9D1; Q92896" "Cell surface interactions at the vascular wall" "" "1" "0" "1.047" "0.830" "0.947" "0.976" "0.845" "1.000" "0.996" "0.770" "0.678" "140.1" "146.6" "116.2" "132.7" "136.7" "118.3" "140.1" "139.5" "107.9" "95.0" "" "" "" "" "" "" "" "" "" "" "126.4" "113.1" "89.9" "89.4" "114.0" "101.0" "118.8" "101.0" "72.8" "95.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1474010075378452952" "False" "High" "IsMasterProtein" "P15924" "Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3" "0.000" "False" "6.574" "1" "2" "2" "2" "2871" "331.6" "6.81" "4.88" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00681, Pf17902, Pf18373, Pf21019" "1832" "ENSG00000096696" "DSP" "B2RTT2; D7RX09; hsa:1832; O75993; P15924; Q14189; Q9UHN4" "Formation of the cornified envelope; Neutrophil degranulation; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer" "9" "0" "0.739" "1.407" "0.870" "0.524" "0.454" "0.381" "0.901" "0.726" "0.534" "106.9" "79.0" "150.4" "93.0" "56.0" "48.5" "40.8" "96.3" "77.6" "57.1" "" "" "" "" "" "" "" "" "" "" "96.5" "60.9" "116.3" "62.6" "46.7" "41.4" "34.6" "69.7" "52.4" "57.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179808201318642480" "False" "High" "IsMasterProtein" "Cont_Q3SZR3" "Alpha-1-acid glycoprotein OS=Bos taurus OX=9913 GN=ORM1 PE=2 SV=1" "0.000" "True" "6.566" "7" "2" "4" "2" "202" "23.2" "5.87" "10.86" "2" "stress response;other biological processes" "non-structural extracellular" "" "Pf00061" "497200" "" "ORM1" "bta:497200; Q3SZR3" "" "" "0" "0" "1.205" "1.049" "0.963" "1.014" "1.372" "0.919" "1.141" "1.642" "0.819" "244.8" "295.0" "256.8" "235.8" "248.3" "335.9" "225.0" "279.2" "402.0" "200.6" "" "" "" "" "" "" "" "" "" "" "221.0" "227.5" "198.6" "158.8" "207.1" "286.7" "190.8" "202.1" "271.1" "200.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6257492621702889989" "False" "High" "IsMasterProtein" "Q10589" "Bone marrow stromal antigen 2 OS=Homo sapiens OX=9606 GN=BST2 PE=1 SV=1" "0.000" "False" "6.553" "6" "1" "1" "1" "180" "19.8" "5.60" "3.95" "1" "stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf16716" "684" "ENSG00000130303" "BST2" "A8K4Y4; hsa:684; Q10589; Q53G07" "Neutrophil degranulation; Interferon alpha/beta signaling; SARS-CoV-1 activates/modulates innate immune responses" "Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling" "5" "0" "1.195" "0.921" "1.145" "1.070" "0.970" "1.172" "1.130" "0.822" "1.010" "138.2" "165.2" "127.3" "158.3" "148.0" "134.1" "162.1" "156.2" "113.6" "139.6" "" "" "" "" "" "" "" "" "" "" "124.8" "127.5" "98.5" "106.6" "123.4" "114.5" "137.5" "113.1" "76.6" "139.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7638543548033193713" "False" "High" "IsMasterProtein" "Q00765" "Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3" "0.000" "False" "6.549" "10" "2" "2" "2" "189" "21.5" "8.10" "5.68" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf03134" "7905" "ENSG00000129625" "REEP5" "B7Z681; D3DT04; hsa:7905; Q00765; Q04198; Q5QGT0; Q9BWH9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1583650821826420104" "False" "High" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "0.000" "False" "6.548" "1" "1" "3" "1" "744" "82.3" "7.78" "9.84" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973; ENSG00000291502" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "M-decay: degradation of maternal mRNAs by maternally stored factors; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "Ciliary landscape" "4" "0" "1.054" "1.205" "0.861" "1.056" "1.024" "1.031" "0.916" "0.945" "1.818" "209.4" "220.7" "252.3" "180.3" "221.3" "214.5" "216.0" "191.9" "197.9" "380.8" "" "" "" "" "" "" "" "" "" "" "189.1" "170.3" "195.1" "121.4" "184.6" "183.1" "183.2" "138.8" "133.5" "380.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338672527715775280" "False" "High" "IsMasterProtein" "Q8IWL3" "Iron-sulfur cluster co-chaperone protein HscB OS=Homo sapiens OX=9606 GN=HSCB PE=1 SV=3" "0.000" "False" "6.546" "8" "1" "1" "1" "235" "27.4" "7.69" "3.44" "1" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf07743, Pf18256" "150274" "ENSG00000100209" "HSCB" "hsa:150274; Q8IWL3; Q9BWS7" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "3" "0" "1.343" "0.773" "1.083" "1.147" "1.238" "1.259" "0.939" "1.026" "1.137" "17.1" "22.9" "13.2" "18.5" "19.6" "21.1" "21.5" "16.0" "17.5" "19.4" "" "" "" "" "" "" "" "" "" "" "15.4" "17.7" "10.2" "12.4" "16.3" "18.0" "18.2" "11.6" "11.8" "19.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5198752139468277763" "False" "High" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "0.000" "False" "6.542" "5" "3" "3" "3" "669" "69.4" "9.67" "6.66" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "RUNX2 regulates bone development" "Ciliary landscape" "2" "0" "1.041" "1.268" "0.890" "1.201" "1.245" "1.151" "0.857" "1.462" "3.333" "79.9" "83.2" "101.4" "71.2" "96.0" "99.5" "92.0" "68.5" "116.9" "266.4" "" "" "" "" "" "" "" "" "" "" "72.2" "64.2" "78.4" "47.9" "80.0" "84.9" "78.0" "49.6" "78.8" "266.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5135100836873347765" "False" "High" "IsMasterProtein" "Q5T200" "Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1" "0.000" "False" "6.538" "1" "2" "2" "2" "1668" "196.5" "9.42" "6.63" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00642" "23091" "ENSG00000123200" "ZC3H13" "A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6" "" "" "0" "0" "1.091" "3.446" "1.106" "0.856" "3.101" "0.818" "1.017" "3.406" "1.743" "76.4" "83.4" "263.2" "84.5" "65.4" "236.9" "62.5" "77.7" "260.2" "133.1" "" "" "" "" "" "" "" "" "" "" "68.9" "64.3" "203.6" "56.9" "54.6" "202.2" "53.0" "56.2" "175.5" "133.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4546155412470536460" "False" "High" "IsMasterProtein" "Q9NQS7" "Inner centromere protein OS=Homo sapiens OX=9606 GN=INCENP PE=1 SV=3" "0.000" "False" "6.536" "1" "1" "1" "1" "918" "105.4" "9.44" "3.34" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03941, Pf12178" "3619" "ENSG00000149503" "INCENP" "A8MQD2; hsa:3619; Q5Y192; Q9NQS7" "SUMOylation of DNA replication proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "1.157" "3.721" "0.992" "0.944" "3.166" "1.022" "1.162" "3.556" "1.773" "38.7" "44.8" "144.1" "38.4" "36.5" "122.5" "39.6" "45.0" "137.7" "68.6" "" "" "" "" "" "" "" "" "" "" "34.9" "34.6" "111.4" "25.9" "30.5" "104.6" "33.6" "32.6" "92.9" "68.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6253369152743795153" "False" "High" "IsMasterProtein" "Q8TD16" "Protein bicaudal D homolog 2 OS=Homo sapiens OX=9606 GN=BICD2 PE=1 SV=1" "0.000" "False" "6.531" "2" "2" "2" "2" "824" "93.5" "5.44" "6.05" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf09730" "23299" "ENSG00000185963" "BICD2" "hsa:23299; O75181; Q5TBQ2; Q5TBQ3; Q8TD16; Q96LH2; Q9BT84; Q9H561" "COPI-independent Golgi-to-ER retrograde traffic" "" "1" "0" "0.973" "0.916" "1.229" "1.175" "0.967" "1.110" "0.795" "1.124" "3.167" "65.1" "63.4" "59.7" "80.0" "76.6" "63.0" "72.3" "51.8" "73.2" "206.3" "" "" "" "" "" "" "" "" "" "" "58.8" "48.9" "46.2" "53.9" "63.9" "53.8" "61.3" "37.5" "49.4" "206.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5138409153076525613" "False" "High" "IsMasterProtein" "Q9HBI1" "Beta-parvin OS=Homo sapiens OX=9606 GN=PARVB PE=1 SV=1" "0.000" "False" "6.508" "3" "1" "1" "1" "364" "41.7" "6.73" "4.08" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00307" "29780" "ENSG00000188677" "PARVB" "B0QYM8; B0QYN1; B2R9X6; hsa:29780; Q5TGJ5; Q86X93; Q96PN1; Q9HBI1; Q9NSP7; Q9UGT3; Q9Y368; Q9Y3L6; Q9Y3L7" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Focal adhesion" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4400189645946568146" "False" "High" "IsMasterProtein" "O00488" "Zinc finger protein 593 OS=Homo sapiens OX=9606 GN=ZNF593 PE=1 SV=2" "0.000" "False" "6.506" "24" "2" "3" "2" "134" "15.2" "9.82" "5.48" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12171" "51042" "ENSG00000142684" "ZNF593" "B2R4S0; hsa:51042; O00488; Q5T2H7" "" "" "0" "0" "1.079" "1.057" "0.919" "1.198" "1.298" "0.734" "0.980" "1.020" "0.656" "22.6" "24.4" "23.9" "20.7" "27.1" "29.3" "16.6" "22.1" "23.0" "14.8" "" "" "" "" "" "" "" "" "" "" "20.4" "18.8" "18.5" "14.0" "22.6" "25.0" "14.1" "16.0" "15.5" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6810289511595074622" "False" "High" "IsMasterProtein" "Q15758" "Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2" "0.000" "False" "6.492" "4" "2" "2" "2" "541" "56.6" "5.48" "6.36" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00375" "6510" "ENSG00000105281" "SLC1A5" "A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01; hsa:6510; O95720; Q15758; Q96RL9; Q9BWQ3; Q9UNP2" "RHOQ GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; RHOH GTPase cycle; RAC3 GTPase cycle; Amino acid transport across the plasma membrane" "TYROBP causal network in microglia; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Metabolic reprogramming in colon cancer; Ferroptosis; Amino acid metabolism in triple-negative breast cancer cells" "11" "0" "1.029" "1.053" "1.106" "1.029" "0.873" "1.027" "1.204" "1.171" "0.562" "267.1" "275.0" "281.4" "295.4" "275.0" "233.2" "274.5" "321.6" "312.7" "150.0" "" "" "" "" "" "" "" "" "" "" "241.1" "212.1" "217.6" "198.9" "229.4" "199.1" "232.8" "232.7" "210.9" "150.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477032751293866758" "False" "High" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "0.000" "False" "6.479" "7" "2" "3" "2" "247" "27.9" "7.74" "3.15" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "SUMOylation of DNA damage response and repair proteins" "" "1" "0" "0.962" "1.034" "1.093" "1.034" "0.886" "1.010" "0.974" "1.090" "0.884" "185.1" "178.0" "191.3" "202.4" "191.4" "163.9" "187.0" "180.3" "201.6" "163.5" "" "" "" "" "" "" "" "" "" "" "167.1" "137.3" "147.9" "136.3" "159.7" "139.9" "158.6" "130.5" "136.0" "163.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3983981062552353097" "False" "High" "IsMasterProtein" "Q92600" "CCR4-NOT transcription complex subunit 9 OS=Homo sapiens OX=9606 GN=CNOT9 PE=1 SV=1" "0.000" "False" "6.468" "7" "2" "2" "2" "299" "33.6" "8.03" "5.89" "2" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04078" "9125" "ENSG00000144580" "CNOT9" "B2RPI0; B5MDQ4; B7Z1E5; hsa:9125; Q92600; Q96IX4" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6180191668945880169" "False" "High" "IsMasterProtein" "Q9H269" "Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2" "0.000" "False" "6.463" "2" "2" "2" "2" "839" "94.6" "6.77" "5.95" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04840, Pf04841" "64601" "ENSG00000215305" "VPS16" "hsa:64601; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5; Q9H269" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141064915599705120" "False" "High" "IsMasterProtein" "Q9P000" "COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2" "0.000" "False" "6.463" "8" "2" "2" "2" "198" "21.8" "5.88" "6.20" "2" "transport;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf07258, Pf20923" "29099" "ENSG00000110442" "COMMD9" "E9PAN2; hsa:29099; Q96FI2; Q9H0R0; Q9P000" "Neutrophil degranulation; Neddylation" "" "2" "0" "1.039" "0.958" "1.087" "1.066" "0.991" "1.095" "1.132" "1.002" "1.280" "118.3" "123.0" "113.4" "128.7" "126.2" "117.3" "129.6" "133.9" "118.5" "151.4" "" "" "" "" "" "" "" "" "" "" "106.8" "94.8" "87.7" "86.6" "105.3" "100.1" "109.9" "96.9" "80.0" "151.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3981569091438122921" "False" "High" "IsMasterProtein" "Q8N4P3" "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3" "0.000" "False" "6.457" "9" "2" "2" "2" "179" "20.3" "6.74" "6.90" "2" "" "" "other molecular function" "Pf13328" "374659" "ENSG00000184508" "HDDC3" "hsa:374659; Q8N4P3" "" "" "0" "0" "0.996" "0.932" "0.964" "0.929" "0.931" "0.892" "1.006" "0.908" "0.712" "259.1" "258.2" "241.6" "249.8" "240.8" "241.4" "231.2" "260.8" "235.3" "184.6" "" "" "" "" "" "" "" "" "" "" "233.9" "199.1" "186.9" "168.2" "200.8" "206.0" "196.1" "188.7" "158.7" "184.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5638474282161267402" "False" "High" "IsMasterProtein" "Q969Z0" "FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1" "0.000" "False" "6.441" "4" "3" "3" "3" "631" "70.7" "7.42" "9.11" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "9238" "ENSG00000136270" "TBRG4" "A4D2L2; A4D2L3; D3DVL5; D3DVL6; hsa:9238; O14710; Q53GI8; Q8NDM4; Q969Z0; Q9BUC6; Q9Y2F6" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "" "1" "0" "1.098" "0.968" "1.065" "0.899" "0.885" "0.956" "0.629" "1.070" "6.798" "99.0" "108.7" "95.9" "105.5" "89.0" "87.6" "94.7" "62.3" "105.9" "673.1" "" "" "" "" "" "" "" "" "" "" "89.4" "83.9" "74.2" "71.0" "74.2" "74.8" "80.3" "45.1" "71.5" "673.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1198198230857353565" "False" "High" "IsMasterProtein" "O43169" "Cytochrome b5 type B OS=Homo sapiens OX=9606 GN=CYB5B PE=1 SV=3" "0.000" "False" "6.436" "8" "1" "1" "1" "150" "16.7" "4.97" "3.73" "1" "other metabolic processes;stress response" "other membranes;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00173" "80777" "ENSG00000103018" "CYB5B" "A8K6B1; hsa:80777; J3KNF8; O43169; Q96CC3; Q9BT35" "Sphingolipid de novo biosynthesis; Phase I - Functionalization of compounds" "Oxidation by cytochrome P450" "3" "0" "0.896" "0.656" "0.690" "0.927" "0.817" "0.736" "0.850" "0.809" "0.996" "69.9" "62.6" "45.8" "48.3" "64.8" "57.1" "51.5" "59.4" "56.6" "69.7" "" "" "" "" "" "" "" "" "" "" "63.1" "48.3" "35.5" "32.5" "54.1" "48.8" "43.7" "43.0" "38.2" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1035023352736906795" "False" "High" "IsMasterProtein" "O00399" "Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1" "0.000" "False" "6.426" "12" "2" "2" "2" "190" "20.7" "6.32" "5.95" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "10671" "ENSG00000104671" "DCTN6" "B2RAC1; hsa:10671; O00399" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "Vasopressin-regulated water reabsorption" "5" "0" "1.031" "0.964" "1.087" "1.106" "0.876" "0.997" "0.886" "1.137" "0.780" "57.8" "59.6" "55.7" "62.8" "63.9" "50.6" "57.6" "51.2" "65.7" "45.1" "" "" "" "" "" "" "" "" "" "" "52.2" "46.0" "43.1" "42.3" "53.3" "43.2" "48.9" "37.1" "44.3" "45.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595092831186639682" "False" "High" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "0.000" "False" "6.411" "5" "2" "2" "2" "368" "41.5" "5.43" "5.27" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "Fragile X syndrome" "6" "0" "1.052" "0.997" "0.870" "1.125" "0.951" "0.850" "0.866" "0.870" "2.289" "25.7" "27.0" "25.6" "22.3" "28.9" "24.4" "21.8" "22.2" "22.3" "58.7" "" "" "" "" "" "" "" "" "" "" "23.2" "20.8" "19.8" "15.0" "24.1" "20.8" "18.5" "16.1" "15.0" "58.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1610110799858015964" "False" "High" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "0.000" "False" "6.411" "11" "2" "4" "2" "150" "16.8" "6.79" "11.39" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Respiratory electron transport; Mitochondrial protein degradation; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase" "9" "0" "1.017" "0.922" "1.132" "0.989" "1.001" "0.951" "1.058" "1.179" "0.945" "223.7" "227.5" "206.2" "253.3" "221.2" "224.0" "212.8" "236.6" "263.8" "211.4" "" "" "" "" "" "" "" "" "" "" "201.9" "175.5" "159.5" "170.5" "184.5" "191.2" "180.5" "171.2" "177.9" "211.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4954031466942572679" "False" "High" "IsMasterProtein" "Q6NW29" "RWD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=RWDD4 PE=1 SV=3" "0.000" "False" "6.406" "5" "1" "1" "1" "188" "21.2" "5.31" "4.32" "1" "" "" "" "Pf05773" "201965" "ENSG00000182552" "RWDD4" "B2RDE9; B4DDP2; hsa:201965; Q6NW29; Q75LA9; Q8WVW2" "" "" "0" "0" "1.116" "0.902" "1.062" "1.042" "0.851" "0.965" "0.796" "0.891" "3.375" "89.1" "99.5" "80.4" "94.6" "92.9" "75.9" "86.0" "70.9" "79.4" "300.8" "" "" "" "" "" "" "" "" "" "" "80.5" "76.7" "62.2" "63.7" "77.5" "64.8" "73.0" "51.3" "53.6" "300.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7421726054682487966" "False" "High" "IsMasterProtein" "Q9NX18" "Succinate dehydrogenase assembly factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF2 PE=1 SV=1" "0.000" "False" "6.399" "10" "2" "4" "2" "166" "19.6" "6.80" "10.91" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf03937" "54949" "ENSG00000167985" "SDHAF2" "hsa:54949; Q9NX18" "" "Mitochondrial complex II assembly" "1" "0" "1.078" "1.082" "1.081" "1.113" "0.952" "1.116" "1.209" "0.970" "0.848" "351.3" "378.8" "380.0" "379.7" "391.0" "334.4" "392.0" "424.6" "340.6" "298.0" "" "" "" "" "" "" "" "" "" "" "317.1" "292.2" "293.9" "255.7" "326.2" "285.4" "332.5" "307.3" "229.8" "298.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2667466145755123608" "False" "High" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "0.000" "False" "6.385" "15" "2" "2" "2" "124" "13.7" "8.28" "6.09" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.950" "1.305" "1.251" "0.910" "1.315" "1.342" "1.041" "1.117" "0.610" "134.1" "127.3" "175.0" "167.7" "122.0" "176.3" "179.9" "139.6" "149.8" "81.8" "" "" "" "" "" "" "" "" "" "" "121.0" "98.2" "135.3" "112.9" "101.8" "150.5" "152.6" "101.0" "101.1" "81.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8109670193418590883" "False" "High" "IsMasterProtein" "O14641" "Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1" "0.000" "False" "6.379" "3" "2" "2" "2" "736" "78.9" "6.02" "5.56" "2" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1856" "ENSG00000004975" "DVL2" "D3DTN3; hsa:1856; O14641; Q53XM0" "RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "29" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7605379253823960098" "False" "High" "IsMasterProtein" "Q96Q83" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 OS=Homo sapiens OX=9606 GN=ALKBH3 PE=1 SV=1" "0.000" "False" "6.369" "6" "2" "2" "2" "286" "33.4" "8.40" "6.22" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf13532" "221120" "ENSG00000166199" "ALKBH3" "A6NDJ1; Q3SYI0; Q6NX57; Q96BU8; Q96Q83" "ALKBH3 mediated reversal of alkylation damage" "Direct reversal repair; 11p11.2 copy number variation syndrome" "3" "0" "1.014" "0.887" "0.965" "0.979" "0.950" "0.959" "1.041" "1.023" "1.093" "284.3" "288.4" "252.1" "274.5" "278.3" "270.0" "272.6" "295.9" "290.7" "310.8" "" "" "" "" "" "" "" "" "" "" "256.7" "222.5" "195.0" "184.8" "232.2" "230.5" "231.3" "214.1" "196.1" "310.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7069915122482910766" "False" "High" "IsMasterProtein" "Q9Y2I7" "1-phosphatidylinositol 3-phosphate 5-kinase OS=Homo sapiens OX=9606 GN=PIKFYVE PE=1 SV=3" "0.000" "False" "6.348" "1" "2" "2" "2" "2098" "237.0" "6.70" "5.22" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00118, Pf00610, Pf01363, Pf01504" "200576" "ENSG00000115020" "PIKFYVE" "hsa:200576; Q08AR7; Q08AR8; Q53ST3; Q53T36; Q8N5H0; Q8NB67; Q9Y2I7" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "" "3" "0" "0.734" "0.846" "0.893" "0.905" "0.959" "0.820" "0.906" "0.867" "1.753" "119.0" "87.3" "100.7" "106.3" "107.8" "114.1" "97.6" "107.8" "103.2" "208.6" "" "" "" "" "" "" "" "" "" "" "107.4" "67.4" "77.9" "71.6" "89.9" "97.4" "82.8" "78.0" "69.6" "208.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1419370867446709471" "False" "High" "IsMasterProtein" "P42677" "Small ribosomal subunit protein eS27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "0.000" "False" "6.345" "23" "2" "7" "1" "84" "9.5" "9.45" "18.85" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "25" "0" "1.026" "1.041" "0.882" "1.030" "0.939" "1.047" "0.892" "1.151" "0.684" "58.4" "59.9" "60.7" "51.5" "60.1" "54.8" "61.1" "52.1" "67.2" "39.9" "" "" "" "" "" "" "" "" "" "" "52.7" "46.2" "47.0" "34.7" "50.2" "46.8" "51.9" "37.7" "45.3" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8271257472643545210" "False" "High" "IsMasterProtein" "Q6PCE3" "Glucose 1,6-bisphosphate synthase OS=Homo sapiens OX=9606 GN=PGM2L1 PE=1 SV=3" "0.000" "False" "6.341" "4" "3" "3" "2" "622" "70.4" "7.15" "5.61" "3" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf02878, Pf02879, Pf02880" "283209" "ENSG00000165434" "PGM2L1" "hsa:283209; Q6PCE3; Q96MQ7; Q9UIK3" "Glycolysis" "" "1" "0" "1.036" "0.906" "1.021" "1.072" "1.013" "0.766" "0.846" "1.154" "0.851" "68.3" "70.8" "61.9" "69.8" "73.3" "69.2" "52.3" "57.8" "78.8" "58.1" "" "" "" "" "" "" "" "" "" "" "61.7" "54.6" "47.9" "47.0" "61.1" "59.1" "44.4" "41.8" "53.2" "58.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4966290939603233061" "False" "High" "IsMasterProtein" "O00461" "Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1" "0.000" "False" "6.334" "3" "2" "2" "2" "696" "81.8" "4.77" "6.37" "2" "" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "27333" "ENSG00000173905" "GOLIM4" "hsa:27333; O00461" "Intra-Golgi traffic" "" "1" "0" "0.989" "0.986" "1.016" "1.182" "1.178" "0.900" "1.057" "1.050" "0.870" "98.9" "97.8" "97.5" "100.4" "116.8" "116.4" "89.0" "104.5" "103.8" "86.0" "" "" "" "" "" "" "" "" "" "" "89.2" "75.4" "75.4" "67.6" "97.4" "99.4" "75.5" "75.6" "70.0" "86.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5432716996293136503" "False" "High" "IsMasterProtein" "P05161" "Ubiquitin-like protein ISG15 OS=Homo sapiens OX=9606 GN=ISG15 PE=1 SV=5" "0.000" "False" "6.320" "12" "2" "2" "2" "165" "17.9" "7.44" "5.78" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00240" "9636" "ENSG00000187608" "ISG15" "hsa:9636; P05161; Q5SVA4; Q7Z2G2; Q96GF0" "RSV-host interactions; PKR-mediated signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "Novel intracellular components of RIG-I-like receptor pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system; Type II interferon signaling" "17" "0" "0.925" "0.807" "0.905" "0.882" "0.943" "0.905" "0.926" "0.852" "2.642" "140.2" "129.7" "113.1" "126.9" "123.7" "132.2" "126.8" "129.8" "119.4" "370.3" "" "" "" "" "" "" "" "" "" "" "126.5" "100.0" "87.5" "85.5" "103.2" "112.8" "107.6" "93.9" "80.6" "370.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4571084566871798353" "False" "High" "IsMasterProtein" "Q9Y2S6" "Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1" "0.000" "False" "6.317" "14" "1" "2" "1" "64" "7.1" "9.99" "5.79" "1" "" "" "" "Pf09072" "51372" "ENSG00000232112" "TMA7" "hsa:51372; Q9P052; Q9Y2S6" "" "" "0" "0" "0.986" "0.921" "0.971" "0.919" "0.968" "1.004" "1.136" "0.887" "0.659" "361.5" "356.4" "333.1" "351.0" "332.3" "350.0" "362.8" "410.7" "320.5" "238.4" "" "" "" "" "" "" "" "" "" "" "326.3" "274.9" "257.6" "236.3" "277.2" "298.7" "307.8" "297.2" "216.2" "238.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335740267375587213" "False" "High" "IsMasterProtein" "P09132" "Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3" "0.000" "False" "6.304" "10" "1" "1" "1" "144" "16.1" "9.85" "4.39" "1" "cell organization and biogenesis;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01922" "6728" "ENSG00000153037" "SRP19" "B2R4E9; D6RCQ5; hsa:6728; P09132; Q05D77; Q96FG6" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1220366376593556815" "False" "High" "IsMasterProtein" "Q9Y5U2" "U5 small nuclear ribonucleoprotein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3" "0.000" "False" "6.291" "3" "1" "2" "1" "329" "34.3" "5.19" "6.21" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15264" "10078" "ENSG00000184281" "TSSC4" "C9JS66; hsa:10078; Q86VL2; Q9BRS6; Q9Y5U2" "" "" "0" "0" "1.072" "0.785" "0.920" "0.946" "0.855" "0.927" "0.913" "0.823" "1.268" "195.0" "209.0" "153.1" "179.4" "184.4" "166.8" "180.8" "178.0" "160.5" "247.2" "" "" "" "" "" "" "" "" "" "" "176.0" "161.2" "118.4" "120.8" "153.8" "142.4" "153.4" "128.8" "108.2" "247.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2098721597077854322" "False" "High" "IsMasterProtein" "Q9NTJ4" "Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1" "0.000" "False" "6.290" "2" "2" "2" "2" "1040" "115.8" "6.57" "6.31" "2" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf17677" "4123" "ENSG00000140400" "MAN2C1" "H3BMX2; H3BQY8; H3BUT6; hsa:4123; Q13358; Q68EM8; Q9NTJ4; Q9UL64" "Lysosomal oligosaccharide catabolism" "" "1" "0" "1.069" "0.921" "0.879" "1.053" "0.981" "0.934" "1.139" "1.022" "0.862" "87.9" "94.0" "81.0" "77.3" "92.6" "86.3" "82.2" "100.1" "89.8" "75.8" "" "" "" "" "" "" "" "" "" "" "79.4" "72.5" "62.6" "52.1" "77.2" "73.7" "69.7" "72.5" "60.6" "75.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4971008711368622204" "False" "High" "IsMasterProtein" "Q9BVW5" "TIMELESS-interacting protein OS=Homo sapiens OX=9606 GN=TIPIN PE=1 SV=2" "0.000" "False" "6.280" "6" "2" "2" "2" "301" "34.5" "4.82" "6.91" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07962" "54962" "ENSG00000075131" "TIPIN" "B2CW64; hsa:54962; Q9BVW5; Q9NWZ6" "Processing of DNA double-strand break ends" "" "1" "0" "0.981" "0.846" "1.040" "0.909" "0.914" "0.999" "0.993" "0.747" "1.571" "112.0" "109.9" "94.8" "116.5" "101.8" "102.4" "112.0" "111.2" "83.7" "175.9" "" "" "" "" "" "" "" "" "" "" "101.1" "84.8" "73.3" "78.5" "84.9" "87.4" "95.0" "80.5" "56.4" "175.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1530625692360911706" "False" "High" "IsMasterProtein" "Q8IWB7" "WD repeat and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDFY1 PE=1 SV=1" "0.000" "False" "6.278" "3" "1" "1" "1" "410" "46.3" "7.33" "3.90" "1" "other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf01363" "57590" "ENSG00000085449" "WDFY1" "hsa:57590; Q53S17; Q8IWB7; Q9H9D5; Q9P2B3" "" "" "0" "0" "1.092" "1.022" "1.158" "0.973" "1.095" "1.109" "1.181" "1.045" "0.799" "84.1" "91.9" "86.0" "97.4" "81.9" "92.1" "93.3" "99.3" "87.9" "67.2" "" "" "" "" "" "" "" "" "" "" "76.0" "70.9" "66.5" "65.6" "68.3" "78.6" "79.2" "71.9" "59.3" "67.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159074218320120217" "False" "High" "IsMasterProtein" "A8MT69" "Centromere protein X OS=Homo sapiens OX=9606 GN=CENPX PE=1 SV=1" "0.000" "False" "6.277" "22" "2" "2" "2" "81" "9.0" "5.90" "3.29" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09415" "201254" "ENSG00000169689" "CENPX" "A8MT69; hsa:201254; O00281; O00282; Q96DD4; Q96F51" "Fanconi Anemia Pathway; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "DNA repair pathways, full network" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7779362395337591117" "False" "High" "IsMasterProtein" "Q96FX7" "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1" "0.000" "False" "6.272" "5" "2" "4" "2" "289" "31.4" "7.36" "10.58" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08704" "115708" "ENSG00000166166" "TRMT61A" "A6NN78; hsa:115708; Q8N7Q9; Q96FX7" "tRNA modification in the nucleus and cytosol" "" "1" "0" "0.964" "0.901" "0.839" "0.950" "0.972" "0.938" "0.993" "0.838" "0.868" "266.6" "257.1" "240.1" "223.8" "253.4" "259.1" "250.2" "264.9" "223.3" "231.4" "" "" "" "" "" "" "" "" "" "" "240.7" "198.3" "185.7" "150.7" "211.4" "221.1" "212.2" "191.7" "150.6" "231.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3357604607996684691" "False" "High" "IsMasterProtein" "Q9NX58" "Cell growth-regulating nucleolar protein OS=Homo sapiens OX=9606 GN=LYAR PE=1 SV=3" "0.000" "False" "6.270" "6" "2" "2" "2" "379" "43.6" "9.57" "5.65" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08790, Pf17848" "55646" "ENSG00000145220" "LYAR" "D3DVS4; hsa:55646; Q6FI78; Q9NX58; Q9NYS1" "" "" "0" "0" "0.755" "0.927" "0.790" "0.886" "0.810" "0.841" "0.828" "0.875" "0.384" "276.3" "208.6" "256.3" "218.3" "244.8" "223.8" "232.5" "228.8" "241.8" "106.0" "" "" "" "" "" "" "" "" "" "" "249.5" "160.9" "198.2" "147.0" "204.2" "191.0" "197.2" "165.6" "163.1" "106.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5575516958920561508" "False" "High" "IsMasterProtein" "Q9H1Y0" "Autophagy protein 5 OS=Homo sapiens OX=9606 GN=ATG5 PE=1 SV=2" "0.000" "False" "6.268" "5" "1" "1" "1" "275" "32.4" "5.77" "4.01" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04106, Pf20637, Pf20638" "9474" "ENSG00000057663" "ATG5" "hsa:9474; O60875; Q5JVR2; Q68DI4; Q9H1Y0; Q9H2B8; Q9HCZ7" "Negative regulators of DDX58/IFIH1 signaling; Macroautophagy; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "Nanoparticle triggered autophagic cell death; Novel intracellular components of RIG-I-like receptor pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Cytosolic DNA-sensing pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "13" "0" "1.081" "0.850" "1.132" "1.006" "0.915" "0.891" "0.716" "0.753" "1.008" "47.9" "51.7" "40.7" "54.2" "48.2" "43.8" "42.7" "34.3" "36.1" "48.3" "" "" "" "" "" "" "" "" "" "" "43.2" "39.9" "31.5" "36.5" "40.2" "37.4" "36.2" "24.8" "24.3" "48.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8708910116115825962" "False" "High" "IsMasterProtein" "Q9HAK2" "Transcription factor COE2 OS=Homo sapiens OX=9606 GN=EBF2 PE=1 SV=4" "0.000" "False" "6.266" "3" "2" "3" "1" "575" "62.6" "9.06" "5.17" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "64641" "ENSG00000221818" "EBF2" "A0PJM4; A6NMF7; F5H645; hsa:64641; Q66VZ3; Q6DK36; Q6IS86; Q6ISA4; Q9HAK2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575991461264525713" "False" "High" "IsMasterProtein" "Q99933" "BAG family molecular chaperone regulator 1 OS=Homo sapiens OX=9606 GN=BAG1 PE=1 SV=4" "0.000" "False" "6.262" "6" "2" "2" "2" "345" "38.8" "7.81" "6.18" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf02179" "573" "ENSG00000107262" "BAG1" "hsa:573; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q99933; Q9Y2V4" "Regulation of HSF1-mediated heat shock response" "Androgen receptor signaling pathway" "2" "0" "1.055" "0.849" "1.028" "0.851" "0.830" "0.969" "0.986" "0.950" "0.795" "164.1" "173.1" "139.4" "168.7" "139.6" "136.2" "158.9" "161.8" "155.9" "130.5" "" "" "" "" "" "" "" "" "" "" "148.1" "133.5" "107.8" "113.6" "116.5" "116.2" "134.8" "117.1" "105.2" "130.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8194889804076803831" "False" "High" "IsMasterProtein" "Q9UBU9" "Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1" "0.000" "False" "6.257" "3" "2" "2" "2" "619" "70.1" "8.51" "3.00" "2" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02136, Pf03943, Pf09162" "10482" "ENSG00000162231" "NXF1" "B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "mRNA processing" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-496325283526098650" "False" "High" "IsMasterProtein" "O75427" "Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LRCH4 PE=1 SV=2" "0.000" "False" "6.242" "3" "1" "1" "1" "683" "73.4" "8.22" "4.50" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "" "Pf00307, Pf13855" "4034" "ENSG00000077454" "LRCH4" "A4D2D5; hsa:4034; O75427; Q8WV85; Q96ID0" "" "" "0" "0" "0.837" "1.841" "1.174" "1.334" "2.051" "1.085" "0.900" "2.389" "2.465" "32.7" "27.4" "60.3" "38.4" "43.7" "67.1" "35.5" "29.5" "78.2" "80.7" "" "" "" "" "" "" "" "" "" "" "29.5" "21.1" "46.6" "25.9" "36.4" "57.3" "30.1" "21.3" "52.7" "80.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6147929922391527183" "False" "High" "IsMasterProtein" "P49116" "Nuclear receptor subfamily 2 group C member 2 OS=Homo sapiens OX=9606 GN=NR2C2 PE=1 SV=1" "0.000" "False" "6.233" "3" "2" "2" "2" "596" "65.4" "6.28" "5.58" "2" "developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7182" "ENSG00000177463" "NR2C2" "A8K3H5; B6ZGT8; hsa:7182; P49116; P55092" "Nuclear Receptor transcription pathway" "Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer" "5" "0" "1.109" "0.910" "1.158" "1.039" "0.859" "0.910" "1.077" "0.975" "1.181" "165.0" "182.9" "150.2" "191.1" "171.3" "141.7" "150.1" "177.8" "160.8" "194.8" "" "" "" "" "" "" "" "" "" "" "148.9" "141.1" "116.2" "128.7" "142.9" "120.9" "127.4" "128.6" "108.5" "194.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9117117300834082613" "False" "High" "IsMasterProtein" "Q9H5N1" "Rab GTPase-binding effector protein 2 OS=Homo sapiens OX=9606 GN=RABEP2 PE=1 SV=2" "0.000" "False" "6.227" "3" "2" "2" "2" "569" "63.5" "4.78" "5.98" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf03528, Pf09311" "79874" "ENSG00000177548" "RABEP2" "hsa:79874; Q9H5N1" "" "Ciliary landscape; 16p11.2 distal deletion syndrome" "2" "0" "1.350" "0.964" "1.431" "0.918" "1.012" "1.091" "1.122" "1.270" "3.328" "26.9" "36.4" "26.0" "38.5" "24.7" "27.3" "29.4" "30.2" "34.2" "89.7" "" "" "" "" "" "" "" "" "" "" "24.3" "28.1" "20.1" "26.0" "20.6" "23.3" "24.9" "21.9" "23.1" "89.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4245870540652335533" "False" "High" "IsMasterProtein" "Q8N8N7" "Prostaglandin reductase 2 OS=Homo sapiens OX=9606 GN=PTGR2 PE=1 SV=1" "0.000" "False" "6.225" "5" "1" "1" "1" "351" "38.5" "5.41" "4.66" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00107, Pf16884" "145482" "ENSG00000140043" "PTGR2" "hsa:145482; Q3L8A4; Q6MZH8; Q8N8N7" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence" "4" "0" "1.214" "0.711" "0.919" "1.147" "0.956" "0.898" "0.907" "1.086" "1.030" "18.7" "22.8" "13.3" "17.2" "21.5" "17.9" "16.8" "17.0" "20.3" "19.3" "" "" "" "" "" "" "" "" "" "" "16.9" "17.6" "10.3" "11.6" "17.9" "15.3" "14.3" "12.3" "13.7" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "784332711560809760" "False" "High" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "0.000" "False" "6.225" "26" "3" "3" "3" "90" "10.3" "6.29" "8.37" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "Mitochondrial protein degradation; Mitochondrial protein import" "" "2" "0" "0.962" "1.016" "0.962" "1.031" "0.872" "1.061" "1.180" "1.035" "0.700" "146.3" "140.8" "148.6" "140.8" "150.8" "127.6" "155.3" "172.6" "151.5" "102.5" "" "" "" "" "" "" "" "" "" "" "132.1" "108.6" "115.0" "94.8" "125.8" "108.9" "131.7" "124.9" "102.2" "102.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-72385411951020745" "False" "High" "IsMasterProtein" "Q5VUM1" "Succinate dehydrogenase assembly factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF4 PE=1 SV=1" "0.000" "False" "6.216" "9" "1" "2" "1" "108" "12.2" "9.36" "5.92" "1" "cell organization and biogenesis;other metabolic processes;stress response" "mitochondrion" "enzyme regulator activity" "Pf07896" "135154" "ENSG00000154079" "SDHAF4" "E1P532; hsa:135154; Q5VUM1" "" "Mitochondrial complex II assembly" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8040183580905194760" "False" "High" "IsMasterProtein" "Q8TC26" "Transmembrane protein 163 OS=Homo sapiens OX=9606 GN=TMEM163 PE=1 SV=1" "0.000" "False" "6.203" "8" "2" "2" "2" "289" "31.4" "7.53" "6.04" "2" "transport;developmental processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "" "81615" "ENSG00000152128" "TMEM163" "hsa:81615; Q53QM3; Q53SV7; Q69YH3; Q8TC26; Q9UFG3" "" "" "0" "0" "1.053" "0.760" "0.960" "0.864" "0.743" "0.798" "0.864" "0.954" "1.126" "34.7" "36.6" "26.4" "33.4" "30.0" "25.8" "27.7" "30.0" "33.2" "39.1" "" "" "" "" "" "" "" "" "" "" "31.4" "28.2" "20.4" "22.5" "25.0" "22.0" "23.5" "21.7" "22.4" "39.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2803114814399122734" "False" "High" "IsMasterProtein" "Q8NFI3" "Cytosolic endo-beta-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=ENGASE PE=1 SV=1" "0.000" "False" "6.202" "2" "2" "2" "2" "743" "83.9" "6.79" "6.20" "2" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf03644" "64772" "ENSG00000167280" "ENGASE" "hsa:64772; Q659F0; Q8NFI3; Q8TB86; Q9H6U4" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "" "1" "0" "1.068" "0.964" "1.115" "1.100" "0.846" "1.051" "1.010" "1.088" "0.810" "83.7" "89.4" "80.7" "93.3" "92.1" "70.8" "88.0" "84.6" "91.0" "67.8" "" "" "" "" "" "" "" "" "" "" "75.5" "69.0" "62.4" "62.8" "76.8" "60.4" "74.6" "61.2" "61.4" "67.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5468986810261152963" "False" "High" "IsMasterProtein" "Q15334" "Lethal(2) giant larvae protein homolog 1 OS=Homo sapiens OX=9606 GN=LLGL1 PE=1 SV=3" "0.000" "False" "6.189" "2" "2" "2" "2" "1064" "115.3" "6.29" "5.90" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf08366" "3996" "ENSG00000131899" "LLGL1" "A7MBM7; hsa:3996; O00188; Q15334; Q58F11; Q86UK6" "" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "1" "0" "1.128" "0.906" "1.138" "1.058" "0.928" "0.951" "0.981" "0.919" "1.262" "122.9" "138.6" "111.4" "139.8" "130.0" "114.1" "116.9" "120.6" "112.9" "155.0" "" "" "" "" "" "" "" "" "" "" "110.9" "106.9" "86.1" "94.2" "108.5" "97.3" "99.2" "87.2" "76.1" "155.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6825792350743248999" "False" "High" "IsMasterProtein" "P07738" "Bisphosphoglycerate mutase OS=Homo sapiens OX=9606 GN=BPGM PE=1 SV=2" "0.000" "False" "6.188" "8" "2" "2" "2" "259" "30.0" "6.54" "5.16" "2" "other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00300" "669" "ENSG00000172331" "BPGM" "A4D1N9; hsa:669; P07738" "Glycolysis" "IL-18 signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5530953877353104582" "False" "High" "IsMasterProtein" "P10721" "Mast/stem cell growth factor receptor Kit OS=Homo sapiens OX=9606 GN=KIT PE=1 SV=1" "0.000" "False" "6.173" "2" "2" "2" "1" "976" "109.8" "6.98" "3.31" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00047, Pf07714" "3815" "ENSG00000157404" "KIT" "B5A956; D5LXN2; D5M931; F5H8F8; hsa:3815; P10721; Q6IQ28; Q99662; Q9UM99" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors; Dasatinib-resistant KIT mutants; Imatinib-resistant KIT mutants; KIT mutants bind TKIs; Masitinib-resistant KIT mutants; Nilotinib-resistant KIT mutants; Regorafenib-resistant KIT mutants; Signaling by kinase domain mutants of KIT; Sunitinib-resistant KIT mutants; Signaling by juxtamembrane domain KIT mutants; Sorafenib-resistant KIT mutants; Signaling by extracellular domain mutants of KIT" "Cardiac progenitor differentiation; Pluripotent stem cell differentiation pathway; Kit receptor signaling pathway; Imatinib and chronic myeloid leukemia; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Breast cancer pathway; Neovascularization processes; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Gastrin signaling pathway; Melanoma; Pleural mesothelioma; Markers of kidney cell lineage; Acute myeloid leukemia; Primary ovarian insufficiency" "36" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4959898328745925415" "False" "High" "IsMasterProtein" "Q6IN84" "rRNA methyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=MRM1 PE=1 SV=1" "0.000" "False" "6.150" "5" "2" "2" "2" "353" "38.6" "7.94" "5.60" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588, Pf08032" "79922" "ENSG00000274853; ENSG00000278619" "MRM1" "A8K8E2; hsa:79922; Q6IN84; Q96GK2; Q9H664" "rRNA modification in the mitochondrion" "17q12 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117262061430317364" "False" "High" "IsMasterProtein" "Q96T88" "E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1" "0.000" "False" "6.138" "2" "1" "1" "1" "793" "89.8" "7.56" "5.28" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "29128" "ENSG00000276043" "UHRF1" "A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7" "Chromatin modifications during the maternal to zygotic transition (MZT); DNA methylation" "Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma" "4" "0" "0.869" "0.986" "1.182" "1.226" "0.966" "0.960" "1.028" "1.199" "2.757" "52.0" "45.2" "51.3" "61.5" "63.8" "50.3" "49.9" "53.5" "62.4" "143.4" "" "" "" "" "" "" "" "" "" "" "46.9" "34.8" "39.7" "41.4" "53.2" "42.9" "42.4" "38.7" "42.1" "143.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-726538263945454181" "False" "High" "IsMasterProtein" "Q01459" "Di-N-acetylchitobiase OS=Homo sapiens OX=9606 GN=CTBS PE=1 SV=1" "0.000" "False" "6.124" "3" "1" "1" "1" "385" "43.7" "6.64" "3.35" "1" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf00704" "1486" "ENSG00000117151" "CTBS" "hsa:1486; Q01459; Q5VX50" "" "" "0" "0" "1.195" "1.210" "1.163" "1.238" "1.211" "1.202" "1.233" "1.285" "0.870" "76.8" "91.8" "92.9" "89.3" "95.0" "93.0" "92.3" "94.7" "98.7" "66.8" "" "" "" "" "" "" "" "" "" "" "69.3" "70.8" "71.9" "60.2" "79.3" "79.4" "78.3" "68.5" "66.5" "66.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008676394331225875" "False" "High" "IsMasterProtein" "Q9ULV3" "Cip1-interacting zinc finger protein OS=Homo sapiens OX=9606 GN=CIZ1 PE=1 SV=2" "0.000" "False" "6.122" "3" "2" "2" "2" "898" "100.0" "6.11" "5.43" "2" "other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "25792" "ENSG00000148337" "CIZ1" "A8K9J8; B4E131; B7ZAS8; hsa:25792; Q5SYW3; Q5SYW5; Q8WU72; Q9H868; Q9NYM8; Q9UHK4; Q9ULV3; Q9Y3F9; Q9Y3G0" "" "" "0" "0" "0.997" "1.117" "1.031" "1.032" "1.040" "0.923" "0.962" "0.848" "1.034" "30.7" "30.6" "34.3" "31.6" "31.7" "31.9" "28.3" "29.5" "26.0" "31.7" "" "" "" "" "" "" "" "" "" "" "27.7" "23.6" "26.5" "21.3" "26.4" "27.2" "24.0" "21.4" "17.6" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5878749091954707236" "False" "High" "IsMasterProtein" "Q9NXA8" "NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT5 PE=1 SV=2" "0.000" "False" "6.122" "5" "1" "1" "1" "310" "33.9" "8.47" "3.72" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf02146" "23408" "ENSG00000124523" "SIRT5" "B4DFM4; B4DYJ5; F5H5Z9; hsa:23408; Q5T294; Q5T295; Q9NXA8; Q9Y6E6" "Transcriptional activation of mitochondrial biogenesis" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "4" "0" "1.326" "1.254" "1.396" "1.227" "1.383" "1.318" "1.139" "1.583" "1.090" "36.4" "48.2" "45.6" "50.8" "44.6" "50.3" "47.9" "41.4" "57.6" "39.7" "" "" "" "" "" "" "" "" "" "" "32.8" "37.2" "35.3" "34.2" "37.2" "42.9" "40.7" "30.0" "38.8" "39.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3899808669823360054" "False" "High" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "0.000" "False" "6.121" "1" "1" "1" "1" "911" "99.9" "7.55" "3.67" "1" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RND2 GTPase cycle; RHOG GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "Envelope proteins and their potential roles in EDMD physiopathology" "12" "0" "0.965" "1.717" "1.133" "0.938" "1.589" "0.654" "0.834" "1.807" "0.986" "28.4" "27.4" "48.7" "32.1" "26.6" "45.1" "18.5" "23.6" "51.3" "28.0" "" "" "" "" "" "" "" "" "" "" "25.6" "21.1" "37.7" "21.6" "22.2" "38.5" "15.7" "17.1" "34.6" "28.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5048841209035306562" "False" "High" "IsMasterProtein" "Q9H845" "Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1" "0.000" "False" "6.108" "3" "2" "2" "2" "621" "68.7" "7.96" "5.57" "2" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "28976" "ENSG00000177646" "ACAD9" "D3DNB8; hsa:28976; Q8WXX3; Q9H845" "Complex I biogenesis" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4637087941136759499" "False" "High" "IsMasterProtein" "O15126" "Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2" "0.000" "False" "6.107" "6" "2" "2" "2" "338" "37.9" "7.42" "3.11" "2" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "9522" "ENSG00000085365" "SCAMP1" "hsa:9522; O15126; O43587; Q6FG23; Q96BX1; Q96QK5" "Neutrophil degranulation" "" "1" "0" "0.918" "0.883" "1.038" "1.004" "0.894" "0.970" "1.055" "0.936" "0.925" "280.8" "257.9" "247.9" "291.4" "281.8" "251.1" "272.4" "296.2" "263.0" "259.9" "" "" "" "" "" "" "" "" "" "" "253.5" "198.9" "191.8" "196.3" "235.1" "214.3" "231.0" "214.4" "177.4" "259.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7465059453910529804" "False" "High" "IsMasterProtein" "Q9NSB8" "Homer protein homolog 2 OS=Homo sapiens OX=9606 GN=HOMER2 PE=1 SV=1" "0.000" "False" "6.102" "6" "2" "2" "2" "354" "40.6" "6.38" "5.00" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00568" "9455" "ENSG00000103942" "HOMER2" "hsa:9455; O95269; O95349; Q9NSB6; Q9NSB7; Q9NSB8; Q9UNT7" "Neurexins and neuroligins" "15q25 copy number variation; Cell lineage map for neuronal differentiation" "3" "0" "1.681" "1.059" "1.401" "1.483" "1.375" "1.262" "1.291" "1.463" "1.523" "34.7" "58.4" "36.8" "48.6" "51.5" "47.7" "43.8" "44.8" "50.8" "52.9" "" "" "" "" "" "" "" "" "" "" "31.3" "45.0" "28.4" "32.7" "42.9" "40.7" "37.1" "32.4" "34.3" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1558588285545917257" "False" "High" "IsMasterProtein" "O75531" "Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1" "0.000" "False" "6.097" "25" "3" "5" "3" "89" "10.1" "6.09" "10.30" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02961" "8815" "ENSG00000175334" "BANF1" "hsa:8815; O60558; O75531; Q6FGG7" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy; Progeria-associated lipodystrophy" "11" "0" "1.219" "0.981" "1.227" "0.959" "0.985" "1.255" "1.042" "1.083" "0.130" "22.8" "27.8" "22.4" "28.0" "21.8" "22.4" "28.6" "23.7" "24.7" "3.0" "" "" "" "" "" "" "" "" "" "" "20.6" "21.4" "17.3" "18.8" "18.2" "19.2" "24.2" "17.2" "16.6" "3.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5380197694992633096" "False" "High" "IsMasterProtein" "Q9BWG4" "Single-stranded DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=SSBP4 PE=1 SV=1" "0.000" "False" "6.087" "5" "2" "3" "1" "385" "39.4" "6.80" "8.01" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04503" "170463" "ENSG00000130511" "SSBP4" "hsa:170463; Q9BWG4; Q9BWW5" "" "" "0" "0" "0.964" "0.850" "0.973" "1.093" "0.819" "1.078" "1.179" "0.890" "0.855" "70.6" "68.0" "60.0" "68.7" "77.1" "57.8" "76.1" "83.2" "62.8" "60.4" "" "" "" "" "" "" "" "" "" "" "63.7" "52.4" "46.4" "46.3" "64.3" "49.3" "64.5" "60.2" "42.4" "60.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2898221823971910502" "False" "High" "IsMasterProtein" "Q96H79" "Zinc finger CCCH-type antiviral protein 1-like OS=Homo sapiens OX=9606 GN=ZC3HAV1L PE=1 SV=2" "0.000" "False" "6.079" "6" "2" "2" "2" "300" "32.9" "8.13" "6.27" "2" "" "cytosol" "" "Pf18606" "92092" "ENSG00000146858" "ZC3HAV1L" "hsa:92092; Q8WUD9; Q96H79" "" "" "0" "0" "1.119" "1.003" "1.382" "1.215" "0.883" "1.148" "0.965" "1.278" "1.366" "54.1" "60.6" "54.3" "74.8" "65.8" "47.8" "62.1" "52.2" "69.2" "74.0" "" "" "" "" "" "" "" "" "" "" "48.9" "46.7" "42.0" "50.4" "54.9" "40.8" "52.7" "37.8" "46.7" "74.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-431742904065760490" "False" "High" "IsMasterProtein" "O75955" "Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3" "0.000" "False" "6.069" "3" "1" "1" "1" "427" "47.3" "7.49" "3.94" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "10211" "ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280" "FLOT1" "B4DVY7; hsa:10211; O75955; Q969J8; Q9UHW1; Q9UNV8" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5897019344324903703" "False" "High" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "0.000" "False" "6.056" "3" "1" "2" "1" "307" "33.9" "6.29" "5.66" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "" "2" "0" "0.956" "0.793" "0.972" "0.990" "0.881" "0.805" "1.095" "0.798" "0.966" "59.8" "57.2" "47.4" "58.2" "59.2" "52.7" "48.1" "65.5" "47.8" "57.8" "" "" "" "" "" "" "" "" "" "" "54.0" "44.1" "36.7" "39.2" "49.4" "45.0" "40.8" "47.4" "32.2" "57.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6548869844035824343" "False" "High" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "0.000" "False" "6.049" "6" "2" "2" "2" "306" "32.4" "9.17" "5.51" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "0.899" "0.848" "1.114" "0.867" "0.844" "1.053" "0.731" "0.977" "3.526" "54.8" "49.3" "46.5" "61.0" "47.5" "46.2" "57.7" "40.1" "53.5" "193.3" "" "" "" "" "" "" "" "" "" "" "49.5" "38.0" "35.9" "41.1" "39.6" "39.5" "48.9" "29.0" "36.1" "193.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1022536969773821467" "False" "High" "IsMasterProtein" "P20702" "Integrin alpha-X OS=Homo sapiens OX=9606 GN=ITGAX PE=1 SV=3" "0.000" "False" "6.047" "2" "2" "2" "2" "1163" "127.7" "6.64" "5.70" "2" "cell adhesion;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00092, Pf00357, Pf01839, Pf08441, Pf20805, Pf21520" "3687" "ENSG00000140678" "ITGAX" "hsa:3687; P20702; Q8IVA6" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; Interleukin-4 and Interleukin-13 signaling" "Integrin-mediated cell adhesion; Complement system; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; TYROBP causal network in microglia; Complement system in neuronal development and plasticity; Extrafollicular and follicular B cell activation by SARS-CoV-2" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6687881647514235914" "False" "High" "IsMasterProtein" "Q147X3" "N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1" "0.000" "False" "6.044" "5" "1" "1" "1" "362" "39.3" "5.52" "3.95" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "122830" "ENSG00000139977" "NAA30" "hsa:122830; Q0IIN2; Q147X3" "Retrograde transport at the Trans-Golgi-Network" "Metapathway biotransformation Phase I and II" "2" "0" "0.685" "0.722" "1.436" "0.735" "0.839" "0.687" "0.775" "0.956" "0.765" "21.5" "14.7" "15.5" "30.8" "15.8" "18.0" "14.7" "16.6" "20.5" "16.4" "" "" "" "" "" "" "" "" "" "" "19.4" "11.3" "12.0" "20.7" "13.2" "15.4" "12.5" "12.0" "13.8" "16.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3856989344168059657" "False" "High" "IsMasterProtein" "P04440" "HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPB1 PE=1 SV=1" "0.000" "False" "6.043" "6" "2" "7" "1" "258" "29.1" "8.57" "22.36" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00969, Pf07654" "3115" "ENSG00000215048; ENSG00000223865; ENSG00000226826; ENSG00000230763; ENSG00000236693; ENSG00000237710" "HLA-DPB1" "A0PFJ7; A5I886; A8YPB3; B5U8B4; B7VF80; B7VF87; B8ZX68; B8ZYT0; B9W5S8; B9W6F7; B9W6F9; C0MPP5; C0MPQ2; C0MPQ3; C0MPQ5; C0MPQ6; C0MPQ7; C4R9J5; C5IZL1; hsa:3115; O00259; O19698; O19700; O19702; O19749; O46884; O77952; O98215; O98216; O98217; O98218; O98219; O98222; O98223; P01916; P04232; P04440; P13763; P79493; P79608; Q0P0L4; Q0ZFN3; Q14279; Q27S71; Q29682; Q29684; Q29698; Q29714; Q29775; Q29776; Q29778; Q29779; Q29781; Q29827; Q29828; Q29879; Q29880; Q29898; Q29977; Q2MGW3; Q30015; Q30031; Q30032; Q30033; Q30034; Q30050; Q30051; Q30052; Q30053; Q30054; Q30055; Q30174; Q4GY31; Q4JHD8; Q5ENE0; Q5ENE1; Q5ENW3; Q5EP46; Q5EP47; Q5EP49; Q5EP51; Q5EP52; Q5EP53; Q5EP56; Q5I4H8; Q5I4H9; Q5ISH4; Q5ISH5; Q5SQ73; Q5STP2; Q5YLA6; Q6IVX1; Q6LBX2; Q6LBX3; Q6LBX4; Q6LBX5; Q6LBX6; Q6LBX7; Q6PWX6; Q6TAS4; Q714U1; Q714U2; Q7YQ10; Q860Z7; Q8HWL7; Q8HWT5; Q8SNC4; Q95HC1; Q95IT7; Q95IT8; Q9BD13; Q9GIM2; Q9GIM4; Q9GIX6; Q9GJ41; Q9MY67; Q9TNT7; Q9TQE2; Q9XS11; Q9XS12" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6653202710982051878" "False" "High" "IsMasterProtein" "Q96RL1" "BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2" "0.000" "False" "6.040" "4" "3" "3" "3" "719" "79.7" "5.45" "7.39" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18282" "51720" "ENSG00000087206" "UIMC1" "A8MSA1; B3KMZ1; B4E3N2; hsa:51720; Q5XKQ1; Q7Z3W7; Q8N5B9; Q96RL1; Q9BZR1; Q9BZR5; Q9UHX7" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "5q35 copy number variation" "6" "0" "0.896" "1.015" "1.142" "1.293" "0.828" "1.212" "0.938" "1.274" "1.087" "16.8" "15.1" "17.1" "19.2" "21.7" "13.9" "20.4" "15.8" "21.4" "18.3" "" "" "" "" "" "" "" "" "" "" "15.2" "11.6" "13.2" "12.9" "18.1" "11.9" "17.3" "11.4" "14.4" "18.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3934808494784224808" "False" "High" "IsMasterProtein" "Q96FJ2" "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" "0.000" "False" "6.032" "20" "2" "2" "1" "89" "10.3" "7.37" "7.56" "2" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01221" "140735" "ENSG00000264364" "DYNLL2" "B2R5B4; hsa:140735; Q96FJ2" "Separation of Sister Chromatids; MHC class II antigen presentation; Aggrephagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Intraflagellar transport; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BMF and translocation to mitochondria" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "19" "1" "0.869" "0.958" "0.971" "0.843" "1.000" "0.974" "0.944" "0.960" "1.142" "97.1" "84.4" "93.1" "94.3" "81.9" "97.2" "94.6" "91.7" "93.3" "110.9" "" "" "" "" "" "" "" "" "" "" "87.7" "65.1" "72.0" "63.5" "68.3" "82.9" "80.3" "66.3" "62.9" "110.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486166187731566186" "False" "High" "IsMasterProtein" "Q9BV57" "Acireductone dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "0.000" "False" "6.025" "11" "2" "2" "2" "179" "21.5" "5.68" "6.07" "2" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine salvage pathway" "Methionine de novo and salvage pathway" "2" "0" "0.977" "1.025" "1.058" "1.017" "1.119" "0.947" "0.947" "1.048" "2.888" "272.9" "266.5" "279.8" "288.7" "277.5" "305.4" "258.4" "258.4" "285.9" "788.1" "" "" "" "" "" "" "" "" "" "" "246.3" "205.6" "216.4" "194.4" "231.5" "260.6" "219.2" "187.0" "192.8" "788.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2081784358139501247" "False" "High" "IsMasterProtein" "Q96ME1" "F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18 PE=1 SV=3" "0.000" "False" "6.020" "4" "2" "2" "2" "718" "78.9" "8.27" "3.03" "2" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937, Pf19729" "80028" "ENSG00000155034" "FBXL18" "A0A024R857; B3KTC9; B4DH63; H0Y6I6; hsa:80028; Q96ME1; Q9BR90; Q9BTC7; Q9HAK7" "Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682819818401791106" "False" "High" "IsMasterProtein" "Q9NZJ0" "Denticleless protein homolog OS=Homo sapiens OX=9606 GN=DTL PE=1 SV=3" "0.000" "False" "6.020" "2" "2" "2" "2" "730" "79.4" "8.87" "6.10" "2" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "51514" "ENSG00000143476" "DTL" "A8K8H8; D3DT98; hsa:51514; Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; Q9NZJ0" "Neddylation; Recognition of DNA damage by PCNA-containing replication complex" "" "2" "0" "0.892" "1.117" "1.019" "0.934" "1.090" "0.981" "1.038" "1.136" "1.273" "140.7" "125.5" "157.2" "143.4" "131.4" "153.4" "138.0" "146.0" "159.8" "179.2" "" "" "" "" "" "" "" "" "" "" "127.0" "96.8" "121.6" "96.6" "109.6" "130.9" "117.1" "105.7" "107.8" "179.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785490494886001566" "False" "High" "IsMasterProtein" "A6NC98" "Coiled-coil domain-containing protein 88B OS=Homo sapiens OX=9606 GN=CCDC88B PE=1 SV=1" "0.000" "False" "6.008" "1" "1" "1" "1" "1476" "164.7" "5.11" "4.05" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf19047" "283234" "ENSG00000168071" "CCDC88B" "A5D8Y5; A6NC98; B5MDM2; hsa:283234; Q05BL2; Q6RUV3; Q8N1Q6; Q8NF44; Q9H0H1" "" "" "0" "0" "1.012" "1.207" "1.123" "0.962" "1.160" "0.985" "0.922" "1.328" "4.287" "89.9" "91.0" "108.6" "101.0" "86.5" "104.3" "88.6" "83.0" "119.5" "385.6" "" "" "" "" "" "" "" "" "" "" "81.2" "70.2" "84.0" "68.0" "72.2" "89.1" "75.1" "60.0" "80.6" "385.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6455184460611174421" "False" "High" "IsMasterProtein" "Q96FN4" "Copine-2 OS=Homo sapiens OX=9606 GN=CPNE2 PE=1 SV=3" "0.000" "False" "5.983" "3" "2" "2" "1" "548" "61.2" "6.07" "6.48" "2" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00168, Pf07002" "221184" "ENSG00000140848" "CPNE2" "hsa:221184; Q68D19; Q719H8; Q86XP9; Q96FN4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-323839447441261697" "False" "High" "IsMasterProtein" "Q9NWK9" "Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1" "0.000" "False" "5.982" "5" "2" "2" "2" "470" "53.9" "5.80" "6.47" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "54680" "ENSG00000117174" "ZNHIT6" "B2RBA1; B4DP13; D3DT20; hsa:54680; Q9H278; Q9H3X3; Q9NWK9; Q9NWN0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4247377094260529852" "False" "High" "IsMasterProtein" "P35408" "Prostaglandin E2 receptor EP4 subtype OS=Homo sapiens OX=9606 GN=PTGER4 PE=1 SV=1" "0.000" "False" "5.969" "6" "1" "1" "1" "488" "53.1" "8.79" "3.50" "1" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00001" "5734" "ENSG00000171522" "PTGER4" "hsa:5734; P35408; Q3MJ87" "G alpha (s) signalling events; Prostanoid ligand receptors" "Small ligand GPCRs; Vitamin D receptor pathway; Relationship between inflammation, COX-2 and EGFR; GPCRs, class A rhodopsin-like; Prostaglandin signaling; Prostaglandin and leukotriene metabolism in senescence ; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence; Prostaglandin synthesis and regulation" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "Not Found" "High" "High" "High" "Not Found" "1" "" "-7104112355135180301" "False" "High" "IsMasterProtein" "Q9UL26" "Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2" "0.000" "False" "5.968" "10" "2" "2" "2" "194" "21.8" "8.15" "5.82" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57403" "ENSG00000124209" "RAB22A" "B3KR86; E1P605; hsa:57403; Q8TF12; Q9H4E6; Q9UL26" "RAB geranylgeranylation" "" "1" "0" "0.824" "1.122" "1.068" "1.001" "1.055" "0.942" "1.149" "1.106" "0.864" "147.2" "121.3" "165.1" "157.2" "147.3" "155.3" "138.6" "169.1" "162.7" "127.1" "" "" "" "" "" "" "" "" "" "" "132.8" "93.6" "127.7" "105.8" "122.8" "132.5" "117.6" "122.4" "109.8" "127.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "756136000491077603" "False" "High" "IsMasterProtein" "P08236" "Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2" "0.000" "False" "5.960" "3" "3" "4" "3" "651" "74.7" "7.02" "7.78" "3" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00703, Pf02836, Pf02837" "2990" "ENSG00000169919" "GUSB" "B4E1F6; E9PCV0; hsa:2990; P08236; Q549U0; Q96CL9" "Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation; MPS VII - Sly syndrome" "Glycosaminoglycan degradation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5875685193594640149" "False" "High" "IsMasterProtein" "Q7Z3U7" "Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3" "0.000" "False" "5.953" "1" "2" "2" "2" "1717" "190.2" "6.06" "3.68" "2" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf09324, Pf12783, Pf16206, Pf16213" "23041" "ENSG00000061987" "MON2" "A5D8U7; A7E2Y0; B9EGP5; F8VWA6; F8W1Z6; hsa:23041; Q7Z3U7; Q86TA2; Q8N3I5; Q8NAI0; Q8NHE2; Q9UPW1" "" "" "0" "0" "1.024" "0.939" "1.107" "0.973" "0.799" "0.988" "0.781" "0.929" "1.381" "137.2" "140.6" "128.8" "151.8" "133.6" "109.7" "135.6" "107.2" "127.5" "189.4" "" "" "" "" "" "" "" "" "" "" "123.9" "108.4" "99.6" "102.2" "111.4" "93.6" "115.0" "77.6" "86.0" "189.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5479152358026622907" "False" "High" "IsMasterProtein" "Q8WV74" "Mitochondrial coenzyme A diphosphatase NUDT8 OS=Homo sapiens OX=9606 GN=NUDT8 PE=1 SV=2" "0.000" "False" "5.948" "7" "2" "2" "2" "236" "25.4" "8.41" "5.59" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00293" "254552" "ENSG00000167799" "NUDT8" "hsa:254552; Q6ZW59; Q8WV74" "Vitamin B5 (pantothenate) metabolism" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1487358643357756863" "False" "High" "IsMasterProtein" "P41214" "Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3" "0.000" "False" "5.946" "4" "2" "2" "2" "584" "64.7" "7.65" "6.77" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01253, Pf17832" "1939" "ENSG00000143486" "EIF2D" "hsa:1939; P41214; Q5SY40; Q8IXV3; Q96DG3; Q96TG7; Q9NR27; Q9NSN0; Q9NV18; Q9NZ21" "" "" "0" "0" "0.948" "1.148" "0.946" "0.959" "0.907" "0.900" "0.563" "1.006" "7.148" "64.1" "60.8" "73.6" "60.6" "61.5" "58.2" "57.7" "36.1" "64.5" "458.3" "" "" "" "" "" "" "" "" "" "" "57.9" "46.9" "56.9" "40.8" "51.3" "49.7" "48.9" "26.1" "43.5" "458.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720179589779934486" "False" "High" "IsMasterProtein" "O96007" "Molybdopterin synthase catalytic subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1" "0.000" "False" "5.944" "9" "1" "2" "1" "188" "20.9" "5.44" "5.79" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02391" "4338" "ENSG00000164172" "MOCS2" "hsa:4338; O96007; Q6IAI3" "Molybdenum cofactor biosynthesis" "Metabolic Epileptic Disorders" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256219212228257535" "False" "High" "IsMasterProtein" "P15104" "Glutamine synthetase OS=Homo sapiens OX=9606 GN=GLUL PE=1 SV=4" "0.000" "False" "5.940" "6" "3" "3" "3" "373" "42.0" "6.89" "8.92" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00120, Pf03951" "2752" "ENSG00000135821" "GLUL" "hsa:2752; P15104; Q499Y9; Q5T9Z1; Q7Z3W4; Q8IZ17" "Glutamate and glutamine metabolism; Astrocytic Glutamate-Glutamine Uptake And Metabolism" "TNF-alpha signaling pathway; Amino acid metabolism; Cell lineage map for neuronal differentiation" "5" "0" "1.067" "0.878" "1.000" "1.003" "0.855" "0.990" "0.976" "0.918" "0.721" "274.0" "292.4" "240.5" "273.9" "274.7" "234.3" "271.2" "267.3" "251.5" "197.6" "" "" "" "" "" "" "" "" "" "" "247.3" "225.6" "186.0" "184.4" "229.2" "200.0" "230.1" "193.5" "169.6" "197.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1753263337049179801" "False" "High" "IsMasterProtein" "O75808" "Calpain-15 OS=Homo sapiens OX=9606 GN=CAPN15 PE=1 SV=1" "0.000" "False" "5.922" "2" "2" "2" "2" "1086" "117.2" "6.71" "3.20" "2" "protein metabolism" "other cell component" "other molecular function" "Pf00641, Pf00648" "6650" "ENSG00000103326" "CAPN15" "B1B1M4; hsa:6650; O75808; Q2KHS2; Q8WTY9; Q9BUW0" "Degradation of the extracellular matrix" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345660777743534482" "False" "High" "IsMasterProtein" "Q9NPJ6" "Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1" "0.000" "False" "5.922" "4" "1" "1" "1" "270" "29.7" "5.10" "3.56" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10018" "29079" "ENSG00000136146" "MED4" "B4DX67; hsa:29079; Q53GB4; Q53H68; Q5T912; Q6FHC4; Q6IA79; Q9BS95; Q9NPJ6; Q9NYR5" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785444937320200778" "False" "High" "IsMasterProtein" "P17544" "Cyclic AMP-dependent transcription factor ATF-7 OS=Homo sapiens OX=9606 GN=ATF7 PE=1 SV=3" "0.000" "False" "5.919" "3" "2" "2" "1" "483" "51.7" "8.00" "6.48" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "11016" "ENSG00000170653" "ATF7" "A5D6Y4; B2RMP1; B4DQL4; hsa:11016; P17544; Q13814; Q8IVR8; Q9UD83" "" "" "0" "0" "0.963" "0.878" "1.041" "1.021" "0.854" "0.958" "0.999" "0.858" "0.910" "128.4" "123.6" "112.8" "133.6" "131.0" "109.7" "123.0" "128.3" "110.2" "116.9" "" "" "" "" "" "" "" "" "" "" "115.9" "95.3" "87.2" "90.0" "109.3" "93.6" "104.3" "92.9" "74.3" "116.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379661527543753299" "False" "High" "IsMasterProtein" "Q6PID8" "Kelch domain-containing protein 10 OS=Homo sapiens OX=9606 GN=KLHDC10 PE=1 SV=1" "0.000" "False" "5.908" "5" "1" "1" "1" "442" "49.1" "9.38" "4.04" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13854" "23008" "ENSG00000128607" "KLHDC10" "hsa:23008; Q6PID8; Q86Y99; Q92554" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "1" "" "2412952300113516382" "False" "High" "IsMasterProtein" "Cont_P28800" "Alpha-2-antiplasmin OS=Bos taurus OX=9913 GN=SERPINF2 PE=1 SV=2" "0.000" "True" "5.890" "4" "2" "2" "2" "492" "54.7" "5.72" "5.76" "2" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00079" "282522" "ENSBIXG00000029361; ENSBTAG00000020859" "SERPINF2" "A0A4W2DRH6; bta:282522; P28800" "Platelet degranulation ; Dissolution of Fibrin Clot" "Complement and coagulation cascades; Blood clotting cascade" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5925761923209875400" "False" "High" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "0.000" "False" "5.890" "6" "2" "2" "2" "385" "44.1" "6.23" "4.91" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855, Pf21459" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "8" "0" "0.904" "0.657" "0.743" "0.755" "0.938" "0.873" "0.338" "0.943" "3.340" "15.9" "14.3" "10.4" "11.8" "12.0" "14.9" "13.8" "5.4" "15.0" "53.0" "" "" "" "" "" "" "" "" "" "" "14.3" "11.1" "8.1" "7.9" "10.0" "12.7" "11.7" "3.9" "10.1" "53.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7173592296681882204" "False" "High" "IsMasterProtein" "Q15651" "High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2" "0.000" "False" "5.881" "17" "2" "5" "2" "99" "10.7" "9.66" "13.99" "2" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "9324" "ENSG00000118418" "HMGN3" "B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7" "" "" "0" "0" "1.192" "1.107" "1.137" "1.143" "1.161" "1.137" "1.202" "1.152" "0.930" "321.9" "383.8" "356.4" "366.0" "368.0" "373.7" "366.1" "386.8" "370.8" "299.4" "" "" "" "" "" "" "" "" "" "" "290.6" "296.0" "275.6" "246.5" "307.0" "319.0" "310.6" "279.9" "250.1" "299.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470194220236547975" "False" "High" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "0.000" "False" "5.881" "8" "2" "2" "2" "312" "35.1" "9.13" "5.17" "2" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "0.923" "1.013" "0.645" "0.826" "0.727" "0.728" "0.780" "0.996" "2.717" "46.0" "42.5" "46.6" "29.7" "38.0" "33.4" "33.5" "35.9" "45.8" "125.0" "" "" "" "" "" "" "" "" "" "" "41.5" "32.8" "36.0" "20.0" "31.7" "28.5" "28.4" "26.0" "30.9" "125.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244987817245821138" "False" "High" "IsMasterProtein" "Q14004" "Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2" "0.000" "False" "5.877" "2" "3" "5" "2" "1512" "164.8" "9.69" "13.53" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8621" "ENSG00000065883" "CDK13" "hsa:8621; Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4" "Neutrophil degranulation; TP53 Regulates Transcription of DNA Repair Genes" "" "2" "0" "1.133" "1.068" "1.034" "1.102" "0.922" "1.080" "0.905" "0.973" "0.948" "152.6" "172.9" "163.1" "157.9" "168.2" "140.6" "164.8" "138.1" "148.5" "144.6" "" "" "" "" "" "" "" "" "" "" "137.8" "133.3" "126.1" "106.3" "140.3" "120.0" "139.8" "99.9" "100.2" "144.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4941414792679987409" "False" "High" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "0.000" "False" "5.876" "5" "2" "2" "2" "316" "34.8" "8.35" "6.19" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "1.097" "1.029" "0.980" "0.949" "1.035" "1.000" "0.792" "1.086" "3.917" "121.7" "133.5" "125.3" "119.3" "115.5" "126.0" "121.7" "96.4" "132.2" "476.8" "" "" "" "" "" "" "" "" "" "" "109.9" "103.0" "96.9" "80.4" "96.4" "107.6" "103.2" "69.7" "89.2" "476.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2082394650260842040" "False" "High" "IsMasterProtein" "Q6P4A8" "Phospholipase B-like 1 OS=Homo sapiens OX=9606 GN=PLBD1 PE=1 SV=2" "0.000" "False" "5.868" "2" "1" "1" "1" "553" "63.2" "9.06" "3.43" "1" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf04916" "79887" "ENSG00000121316" "PLBD1" "A8K4E9; hsa:79887; Q6P4A8; Q9BVV3; Q9H625" "Acyl chain remodelling of PC; Acyl chain remodelling of PE; Acyl chain remodelling of PI; Hydrolysis of LPC" "" "4" "0" "1.018" "0.998" "1.066" "0.970" "1.048" "0.933" "0.971" "1.123" "0.695" "162.9" "165.9" "162.7" "173.6" "158.0" "170.7" "152.1" "158.1" "182.9" "113.3" "" "" "" "" "" "" "" "" "" "" "147.1" "128.0" "125.8" "116.9" "131.8" "145.7" "129.0" "114.4" "123.4" "113.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649705542655534815" "False" "High" "IsMasterProtein" "Q8N573" "Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2" "0.000" "False" "5.866" "2" "1" "1" "1" "874" "97.9" "5.47" "3.40" "1" "stress response;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01476, Pf07534" "55074" "ENSG00000164830" "OXR1" "A6NK11; A8KA34; B3KXL1; B7Z402; B7Z8N5; D3HIS6; hsa:55074; Q3LIB5; Q6ZVK9; Q8N573; Q8N8V0; Q9H266; Q9NWC7" "" "" "0" "0" "1.127" "1.283" "1.428" "1.345" "1.043" "1.295" "0.709" "1.264" "1.042" "15.3" "17.2" "19.6" "21.9" "20.6" "16.0" "19.8" "10.9" "19.3" "16.0" "" "" "" "" "" "" "" "" "" "" "13.8" "13.3" "15.2" "14.7" "17.2" "13.6" "16.8" "7.9" "13.0" "16.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258302069466510735" "False" "High" "IsMasterProtein" "P56279" "T-cell leukemia/lymphoma protein 1A OS=Homo sapiens OX=9606 GN=TCL1A PE=1 SV=1" "0.000" "False" "5.861" "13" "2" "3" "2" "114" "13.5" "5.11" "9.04" "2" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01840" "8115" "ENSG00000100721" "TCL1A" "hsa:8115; P56279; Q6IBK7" "" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "2" "0" "0.798" "0.901" "0.937" "0.841" "0.807" "0.842" "0.889" "0.789" "0.791" "230.6" "184.1" "207.9" "216.2" "194.0" "186.0" "194.1" "205.1" "181.9" "182.3" "" "" "" "" "" "" "" "" "" "" "208.2" "142.0" "160.8" "145.6" "161.9" "158.8" "164.7" "148.4" "122.7" "182.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5259083941231079932" "False" "High" "IsMasterProtein" "Q7Z4G1" "COMM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=COMMD6 PE=1 SV=1" "0.000" "False" "5.859" "24" "2" "2" "2" "85" "9.6" "6.00" "4.83" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07258" "170622" "ENSG00000188243" "COMMD6" "A6NF28; B7ZLN0; hsa:170622; Q5TBK4; Q7Z4G1" "Neddylation" "" "1" "0" "0.969" "1.305" "1.589" "1.276" "1.301" "1.085" "0.977" "0.792" "0.974" "33.9" "32.9" "44.2" "53.9" "43.3" "44.1" "36.8" "33.1" "26.8" "33.0" "" "" "" "" "" "" "" "" "" "" "30.6" "25.3" "34.2" "36.3" "36.1" "37.6" "31.2" "24.0" "18.1" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660276496901993886" "False" "High" "IsMasterProtein" "Q96SY0" "Integrator complex subunit 14 OS=Homo sapiens OX=9606 GN=INTS14 PE=1 SV=2" "0.000" "False" "5.852" "2" "1" "1" "1" "518" "57.4" "5.12" "3.93" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13519, Pf19435, Pf20504" "81556" "ENSG00000138614" "INTS14" "B4DDI6; B4DVD5; hsa:81556; Q49AH8; Q96HX5; Q96SY0; Q9H0S5" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "837370257864581378" "False" "High" "IsMasterProtein" "Q01415" "N-acetylgalactosamine kinase OS=Homo sapiens OX=9606 GN=GALK2 PE=1 SV=1" "0.000" "False" "5.846" "5" "3" "3" "3" "458" "50.3" "6.61" "6.44" "3" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2585" "ENSG00000156958" "GALK2" "hsa:2585; Q01415; Q7Z4Q4" "" "" "0" "0" "0.860" "1.034" "0.695" "1.082" "1.022" "0.984" "1.217" "1.070" "0.787" "14.4" "12.4" "14.9" "10.0" "15.6" "14.7" "14.2" "17.5" "15.4" "11.3" "" "" "" "" "" "" "" "" "" "" "13.0" "9.6" "11.5" "6.7" "13.0" "12.6" "12.0" "12.7" "10.4" "11.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753103137801597372" "False" "High" "IsMasterProtein" "Q99618" "Cell division cycle-associated protein 3 OS=Homo sapiens OX=9606 GN=CDCA3 PE=1 SV=1" "0.000" "False" "5.841" "6" "2" "2" "2" "268" "29.0" "6.43" "5.83" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "" "83461" "ENSG00000111665" "CDCA3" "A8K5V6; D3DUS6; hsa:83461; Q99618" "" "" "0" "0" "0.900" "0.926" "1.218" "1.067" "1.015" "1.088" "1.215" "0.948" "0.671" "108.3" "97.5" "100.3" "131.9" "115.6" "110.0" "117.9" "131.6" "102.7" "72.7" "" "" "" "" "" "" "" "" "" "" "97.8" "75.2" "77.6" "88.8" "96.4" "93.8" "100.0" "95.2" "69.3" "72.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4095542091731415933" "False" "High" "IsMasterProtein" "Q9HA47" "Uridine-cytidine kinase 1 OS=Homo sapiens OX=9606 GN=UCK1 PE=1 SV=1" "0.000" "False" "5.831" "6" "2" "3" "1" "277" "31.4" "7.30" "7.75" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "83549" "ENSG00000130717" "UCK1" "hsa:83549; Q5JT09; Q5JT10; Q5JT12; Q5JT13; Q6IA74; Q96BJ0; Q9HA47" "Pyrimidine salvage" "Fluoropyrimidine activity; Pyrimidine metabolism; IL-18 signaling pathway" "4" "0" "1.042" "0.850" "1.077" "0.929" "0.913" "1.051" "1.008" "0.920" "0.974" "41.6" "43.3" "35.4" "44.8" "38.7" "38.0" "43.7" "42.0" "38.3" "40.5" "" "" "" "" "" "" "" "" "" "" "37.6" "33.4" "27.4" "30.2" "32.2" "32.4" "37.1" "30.4" "25.8" "40.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8286530119888385384" "False" "High" "IsMasterProtein" "P36969" "Phospholipid hydroperoxide glutathione peroxidase GPX4 OS=Homo sapiens OX=9606 GN=GPX4 PE=1 SV=3" "0.000" "False" "5.814" "5" "1" "1" "1" "197" "22.2" "8.37" "3.89" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00255" "2879" "ENSG00000167468" "GPX4" "hsa:2879; O43381; P36969; Q6PJ59; Q9UPK2" "Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "11" "0" "0.987" "0.748" "0.938" "0.966" "0.830" "0.998" "0.815" "0.959" "0.725" "111.9" "110.4" "83.7" "104.9" "108.0" "92.8" "111.6" "91.1" "107.2" "81.1" "" "" "" "" "" "" "" "" "" "" "101.0" "85.2" "64.7" "70.6" "90.1" "79.2" "94.7" "66.0" "72.3" "81.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4293780430971367314" "False" "High" "IsMasterProtein" "Q13371" "Phosducin-like protein OS=Homo sapiens OX=9606 GN=PDCL PE=1 SV=3" "0.000" "False" "5.804" "7" "2" "2" "2" "301" "34.3" "4.73" "6.51" "2" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf02114" "5082" "ENSG00000136940" "PDCL" "hsa:5082; Q13371; Q4VXB6; Q96AF1; Q9UEW7; Q9UFL0; Q9UNX1; Q9UNX2" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" "" "1" "0" "0.801" "0.870" "1.124" "0.765" "0.923" "1.069" "0.790" "0.819" "1.052" "47.9" "38.3" "41.7" "53.8" "36.6" "44.2" "51.2" "37.8" "39.2" "50.4" "" "" "" "" "" "" "" "" "" "" "43.2" "29.6" "32.2" "36.2" "30.6" "37.7" "43.4" "27.4" "26.4" "50.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541335516874274105" "False" "High" "IsMasterProtein" "Q14527" "Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2" "0.000" "False" "5.790" "2" "2" "3" "2" "1009" "113.9" "8.60" "8.33" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf08797, Pf13923" "6596" "ENSG00000071794" "HLTF" "D3DNH3; Q14527; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9" "E3 ubiquitin ligases ubiquitinate target proteins" "Retinoblastoma gene in cancer" "2" "0" "0.986" "0.879" "1.011" "1.114" "0.805" "1.107" "1.023" "0.719" "1.245" "75.3" "74.3" "66.2" "76.2" "83.9" "60.7" "83.4" "77.0" "54.2" "93.8" "" "" "" "" "" "" "" "" "" "" "68.0" "57.3" "51.2" "51.3" "70.0" "51.8" "70.7" "55.8" "36.5" "93.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7170816328475154252" "False" "High" "IsMasterProtein" "Cont_Q2KJF1" "Alpha-1B-glycoprotein OS=Bos taurus OX=9913 GN=A1BG PE=1 SV=1" "0.000" "True" "5.782" "4" "2" "2" "2" "503" "53.5" "5.43" "2.66" "2" "" "non-structural extracellular;plasma membrane;other membranes" "" "Pf00047" "518955" "ENSBTAG00000009735" "A1BG" "bta:518955; Q2KJF1" "Platelet degranulation ; Neutrophil degranulation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758268738613076417" "False" "High" "IsMasterProtein" "Q9HBM0" "Vezatin OS=Homo sapiens OX=9606 GN=VEZT PE=1 SV=3" "0.000" "False" "5.780" "1" "1" "2" "1" "779" "88.6" "5.20" "3.29" "1" "cell adhesion" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity" "Pf12632" "55591" "ENSG00000028203" "VEZT" "hsa:55591; Q6P1Q3; Q9H2F4; Q9H2U5; Q9HBM0; Q9NT70; Q9NVW0; Q9UF91" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4232598259152992278" "False" "High" "IsMasterProtein" "Q86Y56" "Dynein axonemal assembly factor 5 OS=Homo sapiens OX=9606 GN=DNAAF5 PE=1 SV=4" "0.000" "False" "5.779" "1" "1" "1" "1" "855" "93.5" "6.42" "4.84" "1" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf02985" "54919" "ENSG00000164818" "DNAAF5" "hsa:54919; Q69YL1; Q86Y56; Q96FI9; Q9NX75" "" "Ciliopathies" "1" "0" "0.907" "1.010" "1.091" "0.998" "0.924" "0.927" "0.849" "1.019" "3.074" "146.3" "132.7" "147.8" "159.6" "146.0" "135.2" "135.6" "124.3" "149.1" "449.7" "" "" "" "" "" "" "" "" "" "" "132.0" "102.3" "114.3" "107.4" "121.8" "115.4" "115.0" "89.9" "100.6" "449.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8567537084386512250" "False" "High" "IsMasterProtein" "P20933" "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens OX=9606 GN=AGA PE=1 SV=2" "0.000" "False" "5.775" "5" "2" "2" "2" "346" "37.2" "6.28" "5.80" "2" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01112" "175" "ENSG00000038002" "AGA" "B2R7H2; D3DP47; hsa:175; P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8" "Neutrophil degranulation" "" "1" "0" "0.989" "1.098" "0.973" "0.931" "1.019" "0.972" "0.987" "0.937" "0.787" "162.4" "160.6" "178.3" "158.0" "151.2" "165.5" "157.9" "160.3" "152.1" "127.8" "" "" "" "" "" "" "" "" "" "" "146.6" "123.9" "137.9" "106.4" "126.1" "141.2" "133.9" "116.0" "102.6" "127.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7018160903413407228" "False" "High" "IsMasterProtein" "Q9BW85" "Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1" "0.000" "False" "5.773" "6" "2" "2" "1" "323" "37.1" "5.92" "7.08" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf04502" "55702" "ENSG00000105248" "YJU2" "hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16" "mRNA Splicing - Major Pathway" "" "1" "0" "1.061" "1.034" "1.064" "1.030" "0.908" "1.013" "1.087" "0.978" "0.946" "65.7" "69.7" "67.9" "69.9" "67.7" "59.6" "66.6" "71.4" "64.3" "62.1" "" "" "" "" "" "" "" "" "" "" "59.3" "53.8" "52.6" "47.1" "56.5" "50.9" "56.5" "51.7" "43.3" "62.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3000409602916512702" "False" "High" "IsMasterProtein" "O15357" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2" "0.000" "False" "5.758" "1" "2" "2" "1" "1258" "138.5" "6.54" "4.74" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00017, Pf00536" "3636" "ENSG00000165458" "INPPL1" "B2RTX5; hsa:3636; O15357; Q13577; Q13578" "Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells" "EGF/EGFR signaling pathway; Insulin signaling" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-684970281821863116" "False" "High" "IsMasterProtein" "Q9BXW9" "Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2" "0.000" "False" "5.753" "1" "2" "2" "2" "1451" "164.0" "5.88" "5.53" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf14631" "2177" "ENSG00000144554" "FANCD2" "hsa:2177; Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9BXW9; Q9H9T9" "Fanconi Anemia Pathway; TP53 Regulates Transcription of DNA Repair Genes" "miRNA regulation of DNA damage response; 15q13.3 copy number variation syndrome; DNA repair pathways, full network; 15q11q13 copy number variation; DNA damage response" "7" "0" "0.941" "0.797" "1.075" "0.969" "0.780" "0.932" "0.841" "0.783" "2.516" "199.8" "188.0" "159.1" "214.7" "193.7" "155.9" "186.2" "167.9" "156.5" "502.7" "" "" "" "" "" "" "" "" "" "" "180.3" "145.0" "123.1" "144.6" "161.5" "133.1" "158.0" "121.5" "105.5" "502.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385363124040609264" "False" "High" "IsMasterProtein" "Q13217" "DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1" "0.000" "False" "5.750" "2" "1" "1" "1" "504" "57.5" "6.15" "3.20" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00226, Pf00515, Pf13181" "5611" "ENSG00000102580" "DNAJC3" "hsa:5611; Q13217; Q86WT9; Q8N4N2" "Neutrophil degranulation; Viral mRNA Translation; PKR-mediated signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "Photodynamic therapy-induced unfolded protein response" "7" "0" "0.911" "1.470" "0.896" "0.953" "1.351" "1.165" "1.191" "1.027" "2.216" "51.9" "47.3" "76.3" "46.5" "49.4" "70.1" "60.5" "61.8" "53.3" "115.0" "" "" "" "" "" "" "" "" "" "" "46.9" "36.5" "59.0" "31.3" "41.2" "59.8" "51.3" "44.7" "36.0" "115.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5264367170864335030" "False" "High" "IsMasterProtein" "Q96K76" "Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47 PE=1 SV=3" "0.000" "False" "5.741" "2" "2" "2" "2" "1375" "157.2" "5.08" "5.25" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf19718" "55031" "ENSG00000170242" "USP47" "B3KXF5; E9PM46; hsa:55031; Q658U0; Q86Y73; Q8TEP6; Q96K76; Q9BWI0; Q9NWN1" "Ub-specific processing proteases" "" "1" "0" "1.366" "0.905" "0.883" "1.279" "1.131" "1.016" "1.348" "1.164" "7.659" "9.7" "13.3" "8.8" "8.6" "12.4" "11.0" "9.9" "13.1" "11.3" "74.3" "" "" "" "" "" "" "" "" "" "" "8.8" "10.2" "6.8" "5.8" "10.4" "9.4" "8.4" "9.5" "7.6" "74.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7381193083052724868" "False" "High" "IsMasterProtein" "Q9Y6R4" "Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP3K4 PE=1 SV=2" "0.000" "False" "5.737" "1" "2" "2" "2" "1608" "181.6" "6.32" "5.84" "2" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf19431" "4216" "ENSG00000085511" "MAP3K4" "A6H8W0; B7ZLD3; B9EG75; hsa:4216; Q5VTT8; Q5VTT9; Q92612; Q9H408; Q9Y6R4" "" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4258123771778816743" "False" "High" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "0.000" "False" "5.723" "2" "3" "4" "3" "1226" "136.0" "8.65" "6.49" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "Interferon alpha/beta signaling; PKR-mediated signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "Measles virus infection; Cytosolic DNA-sensing pathway" "6" "0" "0.975" "0.709" "1.515" "0.925" "0.566" "1.391" "0.935" "1.133" "0.978" "106.8" "104.2" "75.7" "161.9" "98.8" "60.5" "148.6" "99.8" "121.1" "104.4" "" "" "" "" "" "" "" "" "" "" "96.4" "80.4" "58.5" "109.0" "82.4" "51.6" "126.1" "72.3" "81.6" "104.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1842086300853461210" "False" "High" "IsMasterProtein" "Q9ULL1" "Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens OX=9606 GN=PLEKHG1 PE=1 SV=2" "0.000" "False" "5.721" "1" "1" "2" "1" "1385" "155.3" "6.24" "3.03" "1" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621" "57480" "ENSG00000120278" "PLEKHG1" "hsa:57480; Q5T1F2; Q9ULL1" "CDC42 GTPase cycle; RAC1 GTPase cycle" "Opioid receptor pathways" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2490332894624900384" "False" "High" "IsMasterProtein" "Q92574" "Hamartin OS=Homo sapiens OX=9606 GN=TSC1 PE=1 SV=2" "0.000" "False" "5.714" "1" "1" "1" "1" "1164" "129.7" "6.47" "4.26" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04388" "7248" "ENSG00000165699" "TSC1" "B7Z897; hsa:7248; Q5VVN5; Q92574" "TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "27" "0" "1.082" "0.665" "1.005" "0.945" "0.691" "0.944" "0.897" "0.864" "1.738" "148.3" "160.4" "98.7" "149.0" "140.1" "102.4" "140.0" "133.0" "128.1" "257.8" "" "" "" "" "" "" "" "" "" "" "133.9" "123.7" "76.3" "100.3" "116.9" "87.4" "118.8" "96.2" "86.4" "257.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9085991407022296267" "False" "High" "IsMasterProtein" "P01920" "HLA class II histocompatibility antigen, DQ beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DQB1 PE=1 SV=2" "0.000" "False" "5.713" "5" "1" "1" "1" "261" "30.0" "7.25" "5.38" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3119" "ENSG00000225824; ENSG00000231286; ENSG00000233209" "HLA-DQB1" "A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0; B0S7Y7; B1A0K6; B1GXI3; B3VLT3; B5BLN7; B7VU69; C0MQ34; C0MQ35; C8ZL52; C8ZLJ8; C8ZLJ9; C9DRQ3; hsa:3119; O19708; O19713; O19724; O62861; O78046; O78221; O78223; O98034; O98201; P01917; P01918; P01919; P01920; P03992; P05537; P79482; P79526; P79544; P79551; Q08GC8; Q09035; Q0E4V9; Q1M312; Q29731; Q29877; Q29884; Q29915; Q29966; Q2P9N3; Q2QK85; Q30061; Q30075; Q30076; Q30080; Q30081; Q30082; Q30083; Q30084; Q30089; Q30095; Q31633; Q38I47; Q45UE3; Q4QZB5; Q53I44; Q564J6; Q5G841; Q5ISH1; Q5ISH3; Q5W1E1; Q5Y7G8; Q643R4; Q6B9X1; Q70VH8; Q7YP69; Q8HWH0; Q8MH58; Q8SNB4; Q8SND1; Q8SP70; Q8WMA3; Q9BD17; Q9MYH2; Q9TPA9; Q9XRY6; Q9XRY7; Q9XRZ2" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection" "8" "0" "0.901" "0.696" "0.915" "0.850" "0.849" "0.746" "0.961" "1.021" "0.621" "46.5" "41.9" "32.4" "42.5" "39.5" "39.5" "34.7" "44.6" "47.4" "28.9" "" "" "" "" "" "" "" "" "" "" "41.9" "32.3" "25.0" "28.6" "33.0" "33.7" "29.4" "32.3" "32.0" "28.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7420075580370482485" "False" "High" "IsMasterProtein" "P14209" "CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 PE=1 SV=1" "0.000" "False" "5.710" "5" "1" "1" "1" "185" "18.8" "4.75" "3.92" "1" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf12301" "4267" "ENSG00000002586; ENSG00000292348" "CD99" "A6NIW1; hsa:4267; O00518; P14209; Q6ICV7" "Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "2" "0" "0.984" "0.892" "1.126" "0.901" "0.708" "0.994" "1.067" "0.756" "0.649" "194.3" "191.2" "173.3" "218.7" "175.0" "137.6" "193.1" "207.2" "146.9" "126.1" "" "" "" "" "" "" "" "" "" "" "175.3" "147.5" "134.0" "147.3" "146.0" "117.4" "163.8" "149.9" "99.1" "126.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1136415192925944721" "False" "High" "IsMasterProtein" "Q04864" "Proto-oncogene c-Rel OS=Homo sapiens OX=9606 GN=REL PE=1 SV=1" "0.000" "False" "5.708" "3" "2" "2" "2" "619" "68.5" "5.86" "5.76" "2" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5966" "ENSG00000162924" "REL" "hsa:5966; Q04864; Q17RU2; Q2PNZ7; Q6LDY0" "Activation of NF-kappaB in B cells" "IL-1 signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; miRNA role in immune response in sepsis; Canonical NF-kB pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways; T-cell receptor signaling pathway" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1645614495321622240" "False" "High" "IsMasterProtein" "P57678" "Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2" "0.000" "False" "5.705" "2" "2" "2" "2" "1058" "120.0" "6.04" "6.25" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "50628" "ENSG00000179409" "GEMIN4" "hsa:50628; P57678; Q9NZS7; Q9UG32; Q9Y4Q2" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "" "2" "0" "0.847" "0.942" "0.810" "0.822" "0.877" "0.765" "0.839" "0.767" "3.822" "111.6" "94.6" "105.2" "90.5" "91.8" "97.9" "85.4" "93.7" "85.6" "426.7" "" "" "" "" "" "" "" "" "" "" "100.8" "72.9" "81.3" "60.9" "76.5" "83.5" "72.5" "67.8" "57.8" "426.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3197858597980699967" "False" "High" "IsMasterProtein" "Q9HA64" "Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2" "0.000" "False" "5.704" "7" "2" "3" "2" "309" "34.4" "7.33" "7.93" "2" "protein metabolism;other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf03881" "79672" "ENSG00000141560" "FN3KRP" "hsa:79672; Q969F4; Q9H0U7; Q9HA64" "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8490030146092636123" "False" "High" "IsMasterProtein" "Q7Z422" "SUZ RNA-binding domain-containing OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1" "0.000" "False" "5.701" "11" "2" "3" "2" "152" "17.0" "8.95" "9.54" "2" "" "" "" "Pf12752, Pf12901" "26099" "ENSG00000055070; ENSG00000291379" "SZRD1" "A8MXJ2; C9K0U0; hsa:26099; Q7Z422; Q7Z424; Q8IVM2; Q8TBV3; Q9Y403" "" "" "0" "0" "0.924" "0.975" "0.920" "0.971" "1.116" "0.872" "1.093" "1.069" "0.688" "90.3" "83.4" "88.1" "83.1" "87.7" "100.8" "78.8" "98.8" "96.6" "62.1" "" "" "" "" "" "" "" "" "" "" "81.5" "64.4" "68.1" "56.0" "73.2" "86.1" "66.8" "71.5" "65.2" "62.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2969987479368307007" "False" "High" "IsMasterProtein" "O14657" "Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2" "0.000" "False" "5.700" "3" "1" "1" "1" "336" "38.0" "8.54" "3.27" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;nucleus" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "27348" "ENSG00000136816" "TOR1B" "hsa:27348; O14657" "Cargo recognition for clathrin-mediated endocytosis" "" "1" "0" "1.055" "0.868" "1.212" "1.077" "0.954" "0.872" "1.177" "1.011" "1.033" "76.1" "80.3" "66.1" "92.3" "82.0" "72.6" "66.4" "89.6" "77.0" "78.7" "" "" "" "" "" "" "" "" "" "" "68.7" "62.0" "51.1" "62.2" "68.4" "62.0" "56.3" "64.9" "51.9" "78.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923018383904393967" "False" "High" "IsMasterProtein" "Q8TAP6" "Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1" "0.000" "False" "5.698" "5" "3" "3" "3" "659" "74.4" "6.74" "6.60" "3" "other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15627" "79959" "ENSG00000101624" "CEP76" "B0YJB2; B4DXG5; B4DZW1; hsa:79959; Q658N5; Q8TAP6; Q9H9U7" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Genes related to primary cilium development (based on CRISPR)" "8" "0" "0.971" "1.015" "1.135" "1.063" "0.941" "1.193" "1.160" "0.875" "0.950" "107.6" "104.5" "109.2" "122.2" "114.4" "101.3" "128.4" "124.8" "94.2" "102.2" "" "" "" "" "" "" "" "" "" "" "97.2" "80.6" "84.5" "82.3" "95.4" "86.5" "108.9" "90.3" "63.5" "102.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8206347650273111002" "False" "High" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "0.000" "False" "5.696" "7" "1" "1" "1" "122" "13.3" "8.46" "3.28" "1" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6058304427516802646" "False" "High" "IsMasterProtein" "Q7Z6J9" "tRNA-splicing endonuclease subunit Sen54 OS=Homo sapiens OX=9606 GN=TSEN54 PE=1 SV=3" "0.000" "False" "5.685" "5" "2" "2" "2" "526" "58.8" "7.91" "4.56" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf12928" "283989" "ENSG00000182173" "TSEN54" "hsa:283989; Q7Z6J9; Q86WV3; Q86XE4; Q8N9H2" "tRNA processing in the nucleus" "" "1" "0" "1.027" "1.094" "1.122" "1.122" "1.151" "1.019" "1.024" "1.173" "1.304" "72.2" "74.2" "79.0" "81.1" "81.1" "83.1" "73.6" "74.0" "84.7" "94.2" "" "" "" "" "" "" "" "" "" "" "65.2" "57.2" "61.1" "54.6" "67.6" "71.0" "62.4" "53.5" "57.2" "94.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1824813434461880276" "False" "High" "IsMasterProtein" "P84157" "Matrix-remodeling-associated protein 7 OS=Homo sapiens OX=9606 GN=MXRA7 PE=1 SV=1" "0.000" "False" "5.684" "9" "2" "2" "2" "204" "21.5" "4.26" "6.24" "2" "" "other membranes;ER/Golgi" "" "" "439921" "ENSG00000182534" "MXRA7" "hsa:439921; P84157; Q0P5W3" "" "" "0" "0" "1.063" "0.883" "0.996" "0.976" "0.866" "1.089" "1.003" "0.818" "0.713" "271.5" "288.6" "239.7" "270.4" "264.9" "235.2" "295.7" "272.3" "222.2" "193.5" "" "" "" "" "" "" "" "" "" "" "245.1" "222.6" "185.4" "182.1" "221.0" "200.7" "250.8" "197.1" "149.9" "193.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808375425283248797" "False" "High" "IsMasterProtein" "Q13572" "Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens OX=9606 GN=ITPK1 PE=1 SV=2" "0.000" "False" "5.678" "5" "2" "2" "2" "414" "45.6" "6.16" "5.17" "2" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf05770, Pf17927" "3705" "ENSG00000100605; ENSG00000274958" "ITPK1" "hsa:3705; Q13572; Q9BTL6; Q9H2E7" "Factors involved in megakaryocyte development and platelet production; Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol" "2q37 copy number variation syndrome" "4" "0" "0.803" "0.802" "0.805" "0.903" "0.738" "0.844" "0.777" "0.702" "0.996" "180.5" "144.9" "144.8" "145.3" "162.9" "133.3" "152.3" "140.3" "126.8" "179.9" "" "" "" "" "" "" "" "" "" "" "162.9" "111.8" "112.0" "97.9" "135.9" "113.7" "129.2" "101.5" "85.5" "179.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546161136539191079" "False" "High" "IsMasterProtein" "O60936" "Nucleolar protein 3 OS=Homo sapiens OX=9606 GN=NOL3 PE=1 SV=2" "0.000" "False" "5.665" "9" "1" "1" "1" "208" "22.6" "4.18" "4.02" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00619" "8996" "ENSG00000140939" "NOL3" "B4DFL0; hsa:8996; O60936; O60937" "" "" "0" "0" "1.214" "1.124" "1.253" "1.156" "0.827" "0.893" "0.904" "1.231" "1.003" "12.7" "15.4" "14.2" "15.9" "14.6" "10.5" "11.3" "11.5" "15.6" "12.7" "" "" "" "" "" "" "" "" "" "" "11.4" "11.9" "11.0" "10.7" "12.2" "8.9" "9.6" "8.3" "10.5" "12.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3896694547723499941" "False" "High" "IsMasterProtein" "P19878" "Neutrophil cytosol factor 2 OS=Homo sapiens OX=9606 GN=NCF2 PE=1 SV=2" "0.000" "False" "5.664" "4" "2" "2" "2" "526" "59.7" "6.16" "3.41" "2" "other metabolic processes;stress response;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00564, Pf13181" "4688" "ENSG00000116701" "NCF2" "B2R6Q1; B4DKQ7; B4DQA7; E9PHJ2; E9PHX3; hsa:4688; P19878; Q2PP06; Q8NFC7; Q9BV51" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia; IL-18 signaling pathway; p53 transcriptional gene network; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4950317330528062097" "False" "High" "IsMasterProtein" "Q92466" "DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1" "0.000" "False" "5.655" "4" "2" "2" "2" "427" "47.8" "9.47" "5.33" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "1643" "ENSG00000134574" "DDB2" "B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466" "Ub-specific processing proteases; TP53 Regulates Transcription of DNA Repair Genes; Dual Incision in GG-NER; Neddylation; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623340480838481175" "False" "High" "IsMasterProtein" "Q15287" "RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1" "0.000" "False" "5.655" "5" "1" "1" "1" "305" "34.2" "11.84" "4.79" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10921" "ENSG00000205937" "RNPS1" "A8K1P0; B4DDU8; B4DZU7; B7ZA17; hsa:10921; O75308; Q15287; Q32P25; Q8WY42; Q9NYG3" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "mRNA processing" "7" "0" "0.933" "1.052" "0.771" "0.902" "0.884" "0.933" "1.010" "1.043" "1.056" "141.8" "132.3" "149.1" "109.3" "127.9" "125.3" "132.2" "143.2" "147.9" "149.7" "" "" "" "" "" "" "" "" "" "" "128.0" "102.0" "115.3" "73.6" "106.7" "107.0" "112.2" "103.7" "99.8" "149.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1511141278890819027" "False" "High" "IsMasterProtein" "O14802" "DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2" "0.000" "False" "5.640" "1" "2" "2" "1" "1390" "155.5" "8.48" "4.94" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "11128" "ENSG00000148606" "POLR3A" "hsa:11128; O14802; Q8IW34; Q8TCW5" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway" "9" "0" "1.079" "1.073" "1.044" "0.993" "1.205" "0.971" "0.886" "1.161" "2.905" "32.6" "35.1" "35.0" "34.0" "32.3" "39.2" "31.6" "28.9" "37.8" "94.6" "" "" "" "" "" "" "" "" "" "" "29.4" "27.1" "27.0" "22.9" "27.0" "33.5" "26.8" "20.9" "25.5" "94.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363160010535940059" "False" "High" "IsMasterProtein" "Q9BXI3" "Cytosolic 5'-nucleotidase 1A OS=Homo sapiens OX=9606 GN=NT5C1A PE=1 SV=1" "0.000" "False" "5.640" "4" "1" "1" "1" "368" "41.0" "6.55" "3.13" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf06189" "84618" "ENSG00000116981" "NT5C1A" "hsa:84618; Q3SYB9; Q5TG98; Q9BWT8; Q9BXI3" "Purine catabolism; Pyrimidine catabolism" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6297313033402222307" "False" "High" "IsMasterProtein" "Q8TF01" "Arginine/serine-rich protein PNISR OS=Homo sapiens OX=9606 GN=PNISR PE=1 SV=2" "0.000" "False" "5.623" "1" "1" "1" "1" "805" "92.5" "10.02" "3.50" "1" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15996" "25957" "ENSG00000132424" "PNISR" "A8K540; E1P5D2; hsa:25957; Q5T064; Q5T065; Q6P2B4; Q6P2N4; Q6PJ93; Q6PK36; Q7Z640; Q8N2L1; Q8TF00; Q8TF01; Q96K10; Q96SI3; Q96SM5; Q9P076; Q9P0C0; Q9Y4N3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1871023154594230453" "False" "High" "IsMasterProtein" "Q14241" "Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=3" "0.000" "False" "5.620" "3" "2" "2" "2" "772" "87.2" "9.57" "3.11" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06881, Pf08711" "6924" "ENSG00000011007" "ELOA" "B2R7Q8; hsa:6924; Q14241; Q8IXH1" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; 10q11.21q11.23 copy number variation syndrome" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3678335116251458371" "False" "High" "IsMasterProtein" "P22670" "MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2" "0.000" "False" "5.619" "3" "2" "3" "2" "979" "104.7" "6.29" "4.29" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf04589" "5989" "ENSG00000132005; ENSG00000288283" "RFX1" "hsa:5989; P22670" "" "Alstrom syndrome" "1" "0" "1.530" "1.269" "1.933" "1.151" "1.436" "1.617" "1.015" "0.964" "0.918" "12.8" "19.6" "16.3" "24.8" "14.8" "18.4" "20.7" "13.0" "12.4" "11.8" "" "" "" "" "" "" "" "" "" "" "11.6" "15.1" "12.6" "16.7" "12.3" "15.7" "17.6" "9.4" "8.3" "11.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3252394429536465777" "False" "High" "IsMasterProtein" "Q32P41" "tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=3" "0.000" "False" "5.616" "2" "1" "2" "1" "509" "58.2" "8.62" "6.60" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02475" "57570" "ENSG00000126814" "TRMT5" "B2RN19; hsa:57570; Q32P41; Q9P2F4" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9065508386869284325" "False" "High" "IsMasterProtein" "Q9Y2L5" "Trafficking protein particle complex subunit 8 OS=Homo sapiens OX=9606 GN=TRAPPC8 PE=1 SV=2" "0.000" "False" "5.610" "1" "1" "1" "1" "1435" "160.9" "6.87" "3.63" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf12739" "22878" "ENSG00000153339" "TRAPPC8" "A0JP15; B3KME5; hsa:22878; Q9H0L2; Q9Y2L5" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7072278322173443531" "False" "High" "IsMasterProtein" "Q8N371" "Bifunctional peptidase and arginyl-hydroxylase JMJD5 OS=Homo sapiens OX=9606 GN=KDM8 PE=1 SV=1" "0.000" "False" "5.601" "4" "2" "2" "2" "416" "47.2" "5.80" "2.28" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13621" "79831" "ENSG00000155666" "KDM8" "B4DLU9; hsa:79831; Q6VAK5; Q8N371; Q9H8B1" "Protein hydroxylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4980915021063436064" "False" "High" "IsMasterProtein" "Q9H944" "Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1" "0.000" "False" "5.589" "5" "1" "1" "1" "212" "23.2" "6.87" "3.99" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08612" "9477" "ENSG00000124641" "MED20" "B4DE08; hsa:9477; O95821; Q5T8J4; Q9H944; Q9Y429" "Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions" "" "4" "0" "0.885" "0.688" "0.957" "0.876" "0.878" "0.947" "0.815" "0.887" "1.564" "76.3" "67.5" "52.5" "73.0" "66.8" "67.0" "72.2" "62.2" "67.7" "119.3" "" "" "" "" "" "" "" "" "" "" "68.9" "52.1" "40.6" "49.2" "55.7" "57.2" "61.3" "45.0" "45.6" "119.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1044286030628517247" "False" "High" "IsMasterProtein" "P11532" "Dystrophin OS=Homo sapiens OX=9606 GN=DMD PE=1 SV=3" "0.000" "False" "5.584" "0" "2" "2" "2" "3685" "426.5" "5.88" "6.50" "2" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00397, Pf00435, Pf00569, Pf09068, Pf09069" "1756" "ENSG00000198947" "DMD" "A1L0U9; E7EQR9; E7EQS5; E7ESB2; E9PDN1; E9PDN5; F5GZY3; F8VX32; hsa:1756; P11532; Q02295; Q14169; Q14170; Q5JYU0; Q6NSJ9; Q7KZ48; Q8N754; Q9UCW3; Q9UCW4" "Non-integrin membrane-ECM interactions; Striated Muscle Contraction" "Arrhythmogenic right ventricular cardiomyopathy; Ectoderm differentiation; Striated muscle contraction pathway; Acute viral myocarditis; Affected pathways in Duchenne muscular dystrophy; 13q12.12 copy number variation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1619272264168287387" "False" "High" "IsMasterProtein" "Q8WVT3" "Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3" "0.000" "False" "5.583" "2" "1" "1" "1" "735" "79.3" "4.91" "3.58" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf13174, Pf14559" "51112" "ENSG00000171853" "TRAPPC12" "B3KV01; D6W4Y2; hsa:51112; Q8WVT3; Q8WVW1; Q9Y395" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.904" "1.609" "1.230" "1.259" "1.478" "1.174" "1.015" "1.440" "1.513" "39.7" "35.9" "63.8" "48.8" "49.9" "58.6" "46.6" "40.3" "57.1" "60.0" "" "" "" "" "" "" "" "" "" "" "35.8" "27.7" "49.4" "32.9" "41.7" "50.0" "39.5" "29.1" "38.5" "60.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658645955564383119" "False" "High" "IsMasterProtein" "Q86Y82" "Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1" "0.000" "False" "5.578" "3" "1" "1" "1" "276" "31.6" "5.59" "3.73" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "23673" "ENSG00000117758" "STX12" "B1AJQ7; hsa:23673; O95564; Q86Y82" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274876564336853802" "False" "High" "IsMasterProtein" "Q01804" "OTU domain-containing protein 4 OS=Homo sapiens OX=9606 GN=OTUD4 PE=1 SV=4" "0.000" "False" "5.578" "2" "3" "3" "3" "1114" "124.0" "6.71" "7.45" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02338" "54726" "ENSG00000164164" "OTUD4" "B4DYS4; hsa:54726; Q01804; Q147U2; Q1ZYK1; Q6PG39; Q96MQ5; Q9NT94; Q9UPV6" "" "" "0" "0" "1.317" "1.370" "1.640" "1.046" "1.887" "1.304" "0.894" "1.813" "1.081" "14.2" "18.8" "19.5" "23.4" "14.9" "26.9" "18.6" "12.7" "25.8" "15.4" "" "" "" "" "" "" "" "" "" "" "12.9" "14.5" "15.1" "15.7" "12.4" "22.9" "15.8" "9.2" "17.4" "15.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502285001895834817" "False" "High" "IsMasterProtein" "Q99638" "Cell cycle checkpoint control protein RAD9A OS=Homo sapiens OX=9606 GN=RAD9A PE=1 SV=1" "0.000" "False" "5.573" "3" "1" "1" "1" "391" "42.5" "5.66" "4.68" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04139" "5883" "ENSG00000172613" "RAD9A" "B2RCZ8; hsa:5883; Q6FI29; Q96C41; Q99638" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; NF1 copy number variation syndrome ; DNA damage response" "14" "0" "1.259" "1.354" "0.489" "0.352" "0.995" "0.411" "1.491" "0.365" "0.687" "146.6" "184.5" "198.5" "71.7" "51.5" "145.8" "60.3" "218.5" "53.5" "100.7" "" "" "" "" "" "" "" "" "" "" "132.3" "142.3" "153.5" "48.3" "43.0" "124.5" "51.1" "158.1" "36.1" "100.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8573575756283577734" "False" "High" "IsMasterProtein" "Q8TEH3" "DENN domain-containing protein 1A OS=Homo sapiens OX=9606 GN=DENND1A PE=1 SV=2" "0.000" "False" "5.565" "1" "1" "1" "1" "1009" "110.5" "6.96" "3.27" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf02141, Pf03455, Pf03456" "57706" "ENSG00000119522" "DENND1A" "A8MZA3; B1AM80; B7Z3C8; B7Z669; D3PFD3; hsa:57706; Q05C88; Q5VWF0; Q6PJZ5; Q8IVD6; Q8TEH3; Q9H796" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.154" "1.060" "1.209" "1.102" "1.030" "1.159" "1.129" "1.026" "1.757" "167.4" "193.3" "177.4" "202.4" "184.5" "172.6" "194.0" "189.0" "171.7" "294.3" "" "" "" "" "" "" "" "" "" "" "151.1" "149.1" "137.2" "136.3" "153.9" "147.3" "164.6" "136.8" "115.8" "294.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658757101665122516" "False" "High" "IsMasterProtein" "Q9ULP9" "TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2" "0.000" "False" "5.564" "4" "2" "2" "2" "559" "62.9" "7.36" "5.71" "2" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00566, Pf07534" "57465" "ENSG00000162065" "TBC1D24" "A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9" "TBC/RABGAPs" "" "1" "0" "0.933" "0.743" "0.921" "1.066" "0.814" "0.991" "0.899" "0.818" "0.919" "162.2" "151.4" "120.5" "149.4" "172.9" "132.1" "160.7" "145.8" "132.6" "149.0" "" "" "" "" "" "" "" "" "" "" "146.4" "116.8" "93.2" "100.6" "144.2" "112.7" "136.4" "105.5" "89.5" "149.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8818107332528144144" "False" "High" "IsMasterProtein" "Q9H4E7" "Differentially expressed in FDCP 6 homolog OS=Homo sapiens OX=9606 GN=DEF6 PE=1 SV=1" "0.000" "False" "5.562" "2" "1" "1" "1" "631" "73.9" "6.05" "3.09" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00169" "50619" "ENSG00000023892" "DEF6" "hsa:50619; Q86VF4; Q9H4E7" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8998736333335138172" "False" "High" "IsMasterProtein" "Q08623" "Pseudouridine-5'-phosphatase OS=Homo sapiens OX=9606 GN=PUDP PE=1 SV=3" "0.000" "False" "5.562" "4" "1" "1" "1" "228" "25.2" "5.31" "4.61" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf13419" "8226" "ENSG00000130021" "PUDP" "B2R7X6; B4DV93; B7Z6Q3; E9PAV8; F5GWZ2; hsa:8226; Q08623; Q53F84; Q96EB8" "Pyrimidine salvage" "" "1" "0" "1.121" "1.156" "1.019" "1.022" "1.189" "1.024" "1.027" "1.083" "0.767" "281.1" "315.0" "324.9" "286.3" "287.4" "334.2" "287.9" "288.8" "304.4" "215.7" "" "" "" "" "" "" "" "" "" "" "253.7" "243.0" "251.3" "192.8" "239.7" "285.3" "244.2" "209.0" "205.3" "215.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7719784497129908869" "False" "High" "IsMasterProtein" "O60566" "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3" "0.000" "False" "5.545" "2" "2" "2" "2" "1050" "119.5" "5.27" "5.53" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf08311" "701" "ENSG00000156970" "BUB1B" "B2R6U0; B4DL09; B4DLG3; hsa:701; O60501; O60566; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "12" "0" "1.094" "1.163" "1.035" "1.064" "1.095" "1.021" "0.760" "1.244" "4.585" "114.4" "125.2" "133.0" "118.4" "121.7" "125.2" "116.8" "86.9" "142.3" "524.5" "" "" "" "" "" "" "" "" "" "" "103.3" "96.6" "102.9" "79.8" "101.5" "106.9" "99.1" "62.9" "95.9" "524.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8632982163775733346" "False" "High" "IsMasterProtein" "A6NK58" "Octanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial OS=Homo sapiens OX=9606 GN=LIPT2 PE=1 SV=1" "0.000" "False" "5.542" "10" "3" "3" "3" "231" "25.2" "8.27" "8.99" "3" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "" "387787" "ENSG00000175536" "LIPT2" "A6NK58; hsa:387787" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "1.088" "1.115" "1.139" "1.091" "1.076" "1.076" "1.070" "1.079" "0.996" "248.9" "270.9" "277.6" "283.6" "271.6" "267.8" "267.8" "266.3" "268.5" "248.0" "" "" "" "" "" "" "" "" "" "" "224.7" "209.0" "214.7" "191.0" "226.6" "228.5" "227.2" "192.8" "181.1" "248.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457193127181059495" "False" "High" "IsMasterProtein" "Q8TDR0" "TRAF3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TRAF3IP1 PE=1 SV=1" "0.000" "False" "5.539" "3" "2" "2" "2" "691" "78.6" "7.93" "4.80" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf10243, Pf17749" "26146" "ENSG00000204104" "TRAF3IP1" "hsa:26146; Q6PCT1; Q7L8N9; Q8TDR0; Q9NRD6; Q9Y4Q1" "Intraflagellar transport" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 2q37 copy number variation syndrome; Bardet-Biedl syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-142769344711843061" "False" "High" "IsMasterProtein" "P60468" "Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2" "0.000" "False" "5.535" "11" "1" "2" "1" "96" "10.0" "11.56" "4.90" "1" "protein metabolism;other metabolic processes;stress response;transport" "other membranes;cytosol;ER/Golgi" "translation activity;other molecular function" "Pf03911" "10952" "ENSG00000106803" "SEC61B" "hsa:10952; P38390; P38391; P60468; Q6IBC1" "ER-Phagosome pathway; SRP-dependent cotranslational protein targeting to membrane; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "" "3" "0" "1.019" "0.847" "0.791" "0.862" "0.725" "0.834" "1.018" "0.740" "0.600" "175.4" "178.8" "148.5" "138.8" "151.1" "127.1" "146.2" "178.5" "129.8" "105.2" "" "" "" "" "" "" "" "" "" "" "158.3" "137.9" "114.9" "93.4" "126.0" "108.5" "124.0" "129.2" "87.6" "105.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6666030451106529783" "False" "High" "IsMasterProtein" "Q9NRY2" "SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1" "0.000" "False" "5.533" "9" "1" "1" "1" "104" "11.4" "9.25" "2.60" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf15925" "58493" "ENSG00000148153" "INIP" "hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3508649530452010436" "False" "High" "IsMasterProtein" "P00167" "Cytochrome b5 OS=Homo sapiens OX=9606 GN=CYB5A PE=1 SV=2" "0.000" "False" "5.528" "10" "1" "1" "1" "134" "15.3" "4.96" "3.53" "1" "transport" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00173" "1528" "ENSG00000166347" "CYB5A" "A8MV91; F8WEU4; hsa:1528; P00167; Q6IB14" "Vitamin C (ascorbate) metabolism" "Oxidation by cytochrome P450" "2" "0" "1.259" "1.261" "1.239" "1.071" "1.277" "1.471" "1.076" "1.345" "1.071" "65.6" "82.5" "82.7" "81.3" "70.2" "83.7" "96.4" "70.6" "88.2" "70.2" "" "" "" "" "" "" "" "" "" "" "59.2" "63.7" "64.0" "54.7" "58.6" "71.5" "81.8" "51.1" "59.5" "70.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8083299006508235950" "False" "High" "IsMasterProtein" "O94761" "ATP-dependent DNA helicase Q4 OS=Homo sapiens OX=9606 GN=RECQL4 PE=1 SV=2" "0.000" "False" "5.527" "1" "1" "1" "1" "1208" "133.0" "8.09" "3.80" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf11719" "9401" "ENSG00000160957" "RECQL4" "A0A087WZ30; hsa:9401; O94761; Q3Y424; Q96DW2; Q96F55" "" "Primary ovarian insufficiency" "1" "0" "1.323" "1.145" "1.370" "1.159" "1.184" "0.778" "1.022" "1.339" "1.434" "16.1" "21.3" "18.5" "22.1" "18.7" "19.1" "12.5" "16.5" "21.6" "23.1" "" "" "" "" "" "" "" "" "" "" "14.6" "16.5" "14.3" "14.9" "15.6" "16.3" "10.6" "11.9" "14.6" "23.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8637323044109722120" "False" "High" "IsMasterProtein" "Q2NKX8" "DNA excision repair protein ERCC-6-like OS=Homo sapiens OX=9606 GN=ERCC6L PE=1 SV=1" "0.000" "False" "5.518" "1" "1" "1" "1" "1250" "141.0" "5.31" "4.46" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "54821" "ENSG00000186871" "ERCC6L" "hsa:54821; Q2NKX8; Q8NCI1; Q96H93; Q9NXQ8" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.182" "1.341" "1.353" "1.130" "1.403" "1.153" "0.911" "1.450" "3.574" "38.1" "45.1" "51.1" "51.6" "43.1" "53.5" "44.0" "34.8" "55.3" "136.3" "" "" "" "" "" "" "" "" "" "" "34.4" "34.8" "39.6" "34.7" "35.9" "45.7" "37.3" "25.2" "37.3" "136.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3269351355245221217" "False" "High" "IsMasterProtein" "Q8NF37" "Lysophosphatidylcholine acyltransferase 1 OS=Homo sapiens OX=9606 GN=LPCAT1 PE=1 SV=2" "0.000" "False" "5.508" "2" "1" "1" "1" "534" "59.1" "6.02" "4.10" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01553, Pf13833" "79888" "ENSG00000153395" "LPCAT1" "hsa:79888; Q1HAQ1; Q7Z4G6; Q8N3U7; Q8NF37; Q8WUL8; Q9GZW6" "Neutrophil degranulation; Synthesis of PA; Acyl chain remodelling of PC; Acyl chain remodelling of PG; Synthesis of PC" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122628487347765753" "False" "High" "IsMasterProtein" "P41273" "Tumor necrosis factor ligand superfamily member 9 OS=Homo sapiens OX=9606 GN=TNFSF9 PE=1 SV=1" "0.000" "False" "5.501" "11" "2" "2" "2" "254" "26.6" "7.02" "5.21" "2" "cell-cell signaling;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf00229" "8744" "ENSG00000125657" "TNFSF9" "hsa:8744; P41273; Q2M3S2" "TNFs bind their physiological receptors" "Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling" "2" "0" "1.113" "0.964" "1.151" "1.108" "0.710" "1.001" "1.145" "0.876" "0.667" "125.9" "140.1" "121.3" "144.8" "139.4" "89.3" "126.0" "144.1" "110.2" "84.0" "" "" "" "" "" "" "" "" "" "" "113.6" "108.0" "93.8" "97.5" "116.3" "76.3" "106.8" "104.3" "74.3" "84.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4655855300014543961" "False" "High" "IsMasterProtein" "Q06330" "Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3" "0.000" "False" "5.495" "4" "2" "2" "2" "500" "55.6" "7.18" "5.57" "2" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09270, Pf09271, Pf20144" "3516" "ENSG00000168214" "RBPJ" "B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Formation of paraxial mesoderm; Somitogenesis; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; Notch signaling pathway" "20" "0" "0.972" "0.969" "1.174" "0.972" "0.985" "0.970" "0.840" "1.152" "0.854" "73.5" "71.5" "71.3" "86.3" "71.5" "72.4" "71.3" "61.8" "84.7" "62.8" "" "" "" "" "" "" "" "" "" "" "66.4" "55.1" "55.1" "58.1" "59.6" "61.8" "60.5" "44.7" "57.1" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7379304699154124017" "False" "High" "IsMasterProtein" "Q7Z7C8" "Transcription initiation factor TFIID subunit 8 OS=Homo sapiens OX=9606 GN=TAF8 PE=1 SV=1" "0.000" "False" "5.490" "3" "1" "1" "1" "310" "34.2" "6.46" "3.49" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07524, Pf10406" "129685" "ENSG00000137413" "TAF8" "hsa:129685; Q5T0K1; Q7Z7C8; Q8N4R9; Q96M52" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "1.075" "0.969" "1.147" "1.059" "1.008" "0.983" "1.241" "1.045" "1.086" "132.7" "142.6" "128.6" "152.2" "140.5" "133.8" "130.4" "164.6" "138.6" "144.1" "" "" "" "" "" "" "" "" "" "" "119.7" "110.0" "99.4" "102.5" "117.2" "114.2" "110.6" "119.1" "93.5" "144.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1388353290409054284" "False" "High" "IsMasterProtein" "Q9NNW7" "Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3" "0.000" "False" "5.489" "2" "1" "1" "1" "524" "56.5" "7.50" "4.05" "1" "stress response;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf02852, Pf07992" "10587" "ENSG00000184470" "TXNRD2" "hsa:10587; O95840; Q96IJ2; Q9H2Z5; Q9NNW7; Q9NZV3; Q9NZV4; Q9P2Y0; Q9P2Y1; Q9UQU8" "Detoxification of Reactive Oxygen Species" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Oxidative stress response; 22q11.2 copy number variation syndrome" "7" "0" "1.103" "1.189" "1.079" "1.242" "1.684" "1.177" "1.230" "1.314" "1.086" "64.7" "71.4" "77.0" "69.8" "80.4" "109.1" "76.2" "79.6" "85.1" "70.3" "" "" "" "" "" "" "" "" "" "" "58.4" "55.1" "59.5" "47.0" "67.1" "93.1" "64.6" "57.6" "57.4" "70.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7084160994910384820" "False" "High" "IsMasterProtein" "Q96G04" "Protein-lysine N-methyltransferase EEF2KMT OS=Homo sapiens OX=9606 GN=EEF2KMT PE=1 SV=2" "0.000" "False" "5.487" "3" "1" "1" "1" "330" "36.9" "6.05" "3.26" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf10294, Pf14904" "196483" "ENSG00000118894" "EEF2KMT" "D3DUF0; Q96G04; Q96S85" "Protein methylation" "" "1" "0" "0.988" "0.830" "0.787" "0.886" "0.809" "1.018" "0.923" "0.931" "0.985" "119.9" "118.5" "99.5" "94.4" "106.2" "97.0" "122.1" "110.7" "111.7" "118.2" "" "" "" "" "" "" "" "" "" "" "108.3" "91.4" "76.9" "63.5" "88.6" "82.8" "103.6" "80.1" "75.3" "118.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5248794698895072137" "False" "High" "IsMasterProtein" "Q9NVC6" "Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2" "0.000" "False" "5.484" "3" "2" "3" "2" "651" "72.8" "7.44" "7.86" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10156" "9440" "ENSG00000042429" "MED17" "B3KN07; hsa:9440; Q9HA81; Q9NVC6; Q9UNP7; Q9Y2W0; Q9Y660" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.137" "0.797" "0.908" "1.180" "0.909" "0.946" "0.852" "0.720" "1.827" "41.8" "47.5" "33.3" "37.9" "49.3" "38.0" "39.6" "35.6" "30.1" "76.4" "" "" "" "" "" "" "" "" "" "" "37.7" "36.7" "25.8" "25.6" "41.1" "32.4" "33.6" "25.8" "20.3" "76.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1117159967779804568" "False" "High" "IsMasterProtein" "Q7L4I2" "Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1" "0.000" "False" "5.469" "2" "1" "1" "1" "434" "50.5" "11.33" "3.78" "1" "" "" "" "Pf15477" "65117" "ENSG00000111011" "RSRC2" "hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864" "" "" "0" "0" "1.193" "0.986" "1.195" "1.126" "1.019" "1.017" "1.112" "1.112" "0.805" "74.4" "88.8" "73.4" "88.9" "83.8" "75.9" "75.7" "82.7" "82.8" "59.9" "" "" "" "" "" "" "" "" "" "" "67.2" "68.5" "56.8" "59.9" "69.9" "64.7" "64.2" "59.9" "55.8" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857902194460077614" "False" "High" "IsMasterProtein" "Q13535" "Serine/threonine-protein kinase ATR OS=Homo sapiens OX=9606 GN=ATR PE=1 SV=3" "0.000" "False" "5.463" "1" "2" "2" "2" "2644" "301.2" "7.43" "5.34" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08064" "545" "ENSG00000175054" "ATR" "hsa:545; Q13535; Q59HB2; Q7KYL3; Q93051; Q9BXK4" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic synapsis; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; Cell cycle; ATR signaling; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; NIPBL role in DNA damage - Cornelia de Lange syndrome; DNA damage response" "19" "0" "0.630" "0.942" "0.879" "0.681" "0.718" "0.828" "0.998" "0.787" "0.969" "116.9" "73.7" "110.2" "102.8" "79.6" "84.0" "96.8" "116.7" "92.1" "113.3" "" "" "" "" "" "" "" "" "" "" "105.6" "56.8" "85.2" "69.2" "66.4" "71.7" "82.1" "84.5" "62.1" "113.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8993746763041335004" "False" "High" "IsMasterProtein" "Q69YQ0" "Cytospin-A OS=Homo sapiens OX=9606 GN=SPECC1L PE=1 SV=3" "0.000" "False" "5.461" "2" "3" "3" "2" "1117" "124.5" "5.76" "8.73" "3" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00307" "23384" "ENSG00000100014" "SPECC1L" "B7Z758; F5H1H6; hsa:23384; O15081; Q69YQ0" "" "" "0" "0" "1.164" "1.566" "1.003" "1.169" "1.193" "1.134" "0.936" "1.426" "2.196" "49.7" "57.8" "77.8" "49.8" "58.1" "59.3" "56.3" "46.5" "70.8" "109.1" "" "" "" "" "" "" "" "" "" "" "44.8" "44.6" "60.2" "33.6" "48.4" "50.6" "47.8" "33.7" "47.8" "109.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412599355076663570" "False" "High" "IsMasterProtein" "Q8WV92" "MIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MITD1 PE=1 SV=1" "0.000" "False" "5.458" "4" "1" "2" "1" "249" "29.3" "8.00" "5.48" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04212, Pf16565" "129531" "ENSG00000158411" "MITD1" "hsa:129531; Q69YV0; Q8WV92" "" "TAR syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8438939394960091078" "False" "High" "IsMasterProtein" "O00116" "Alkyldihydroxyacetonephosphate synthase, peroxisomal OS=Homo sapiens OX=9606 GN=AGPS PE=1 SV=1" "0.000" "False" "5.456" "2" "1" "1" "1" "658" "72.9" "7.34" "3.61" "1" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01565, Pf02913" "8540" "ENSG00000018510" "AGPS" "A5D8U9; hsa:8540; O00116; Q2TU35" "Plasmalogen biosynthesis; TYSND1 cleaves peroxisomal proteins" "Triacylglyceride synthesis" "4" "0" "1.233" "0.686" "0.714" "1.105" "0.633" "0.933" "1.134" "0.764" "0.387" "32.1" "39.6" "22.0" "22.9" "35.5" "20.3" "30.0" "36.4" "24.5" "12.4" "" "" "" "" "" "" "" "" "" "" "29.0" "30.5" "17.0" "15.4" "29.6" "17.4" "25.4" "26.4" "16.5" "12.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-123895126992999128" "False" "High" "IsMasterProtein" "Q96BR5" "Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2" "0.000" "False" "5.452" "7" "2" "2" "2" "231" "25.7" "6.02" "6.03" "2" "" "mitochondrion;nucleus" "" "Pf08238" "65260" "ENSG00000162377" "COA7" "hsa:65260; Q0P6I7; Q96BR5; Q9H9Z9" "" "" "0" "0" "0.960" "0.785" "0.883" "0.925" "0.862" "0.768" "1.024" "0.918" "0.969" "54.2" "52.0" "42.5" "47.8" "50.1" "46.7" "41.6" "55.5" "49.7" "52.5" "" "" "" "" "" "" "" "" "" "" "48.9" "40.1" "32.9" "32.2" "41.8" "39.9" "35.3" "40.1" "33.5" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4583007171926660229" "False" "High" "IsMasterProtein" "Q9H1I8" "Activating signal cointegrator 1 complex subunit 2 OS=Homo sapiens OX=9606 GN=ASCC2 PE=1 SV=3" "0.000" "False" "5.451" "2" "1" "1" "1" "757" "86.3" "5.16" "4.62" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf02845" "84164" "ENSG00000100325" "ASCC2" "B7Z8E0; F5H6J9; hsa:84164; Q4TT54; Q8TAZ0; Q9H1I8; Q9H711; Q9H9D6" "ALKBH3 mediated reversal of alkylation damage" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408450596310404748" "False" "High" "IsMasterProtein" "Q9UHA4" "Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1" "0.000" "False" "5.450" "14" "2" "3" "2" "124" "13.6" "7.34" "5.74" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08923" "8649" "ENSG00000109270" "LAMTOR3" "B2R4A1; hsa:8649; J3KMX4; Q9H364; Q9UHA4" "Neutrophil degranulation; Amino acids regulate mTORC1; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; MAP2K and MAPK activation; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590032029601755120" "False" "High" "IsMasterProtein" "O75935" "Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1" "0.000" "False" "5.450" "14" "3" "3" "3" "186" "21.1" "5.47" "8.55" "3" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07426" "11258" "ENSG00000137100" "DCTN3" "A6NII7; B2RBM5; hsa:11258; O75935; Q5T1I5; Q5T1I7; Q5T8G3; Q9BPU8" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "11" "0" "0.851" "0.887" "0.966" "0.892" "0.989" "0.881" "0.858" "0.964" "1.208" "183.4" "156.0" "162.7" "177.2" "163.5" "181.3" "161.6" "157.2" "176.8" "221.5" "" "" "" "" "" "" "" "" "" "" "165.5" "120.3" "125.8" "119.3" "136.4" "154.7" "137.1" "113.8" "119.3" "221.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9179155935409940173" "False" "High" "IsMasterProtein" "Q15750" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens OX=9606 GN=TAB1 PE=1 SV=1" "0.000" "False" "5.447" "4" "2" "2" "2" "504" "54.6" "5.52" "4.91" "2" "developmental processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "10454" "ENSG00000100324" "TAB1" "hsa:10454; Q15750; Q2PP09; Q8IZW2" "NOD1/2 Signaling Pathway; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; TGF-beta signaling pathway; MAPK signaling pathway; TLR4 signaling and tolerance; miRNA role in immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; Toll-like receptor signaling pathway" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677934760849169098" "False" "High" "IsMasterProtein" "Q8IVH4" "Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1" "0.000" "False" "5.447" "4" "2" "2" "2" "418" "46.5" "9.29" "5.79" "2" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03308" "166785" "ENSG00000151611" "MMAA" "B3KX40; hsa:166785; Q495G7; Q8IVH4" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104257487773187704" "False" "High" "IsMasterProtein" "Q0PNE2" "Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1" "0.000" "False" "5.443" "6" "2" "2" "2" "266" "29.8" "6.84" "6.35" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf09807" "54859" "ENSG00000163832" "ELP6" "hsa:54859; Q0PNE2; Q9BW57; Q9NXJ3" "HATs acetylate histones" "" "1" "0" "0.957" "0.834" "1.137" "1.023" "0.937" "1.107" "1.044" "1.093" "1.079" "75.5" "72.3" "63.0" "85.9" "77.3" "70.8" "83.6" "78.9" "82.6" "81.5" "" "" "" "" "" "" "" "" "" "" "68.2" "55.8" "48.7" "57.8" "64.5" "60.4" "70.9" "57.1" "55.7" "81.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8682712823667695648" "False" "High" "IsMasterProtein" "Q7Z2E3" "Aprataxin OS=Homo sapiens OX=9606 GN=APTX PE=1 SV=2" "0.000" "False" "5.443" "5" "2" "2" "2" "356" "40.7" "9.17" "2.55" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11969, Pf16278, Pf17913" "54840" "ENSG00000137074" "APTX" "A8MTN4; D3DRK9; D3DRL0; hsa:54840; Q0P662; Q5T781; Q5T782; Q5T784; Q6JV81; Q6JV82; Q6JV85; Q7Z2E3; Q7Z2F3; Q7Z336; Q7Z5R5; Q7Z6V7; Q7Z6V8; Q9NXM5" "" "" "0" "0" "1.154" "1.156" "1.236" "0.973" "0.926" "0.992" "1.097" "1.239" "3.061" "33.0" "38.0" "38.1" "40.7" "32.1" "30.5" "32.7" "36.1" "40.8" "100.9" "" "" "" "" "" "" "" "" "" "" "29.8" "29.3" "29.5" "27.4" "26.8" "26.0" "27.7" "26.2" "27.5" "100.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3341461915485741514" "False" "High" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "0.000" "False" "5.438" "3" "1" "2" "1" "420" "47.0" "8.73" "6.92" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "rRNA modification in the mitochondrion" "" "1" "0" "1.112" "0.951" "0.929" "1.057" "0.961" "1.011" "0.876" "0.951" "0.692" "81.3" "90.4" "77.3" "75.5" "86.0" "78.2" "82.2" "71.2" "77.3" "56.3" "" "" "" "" "" "" "" "" "" "" "73.4" "69.7" "59.8" "50.8" "71.7" "66.7" "69.7" "51.5" "52.2" "56.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "967030651674579734" "False" "High" "IsMasterProtein" "Q9NV88" "Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2" "0.000" "False" "5.408" "3" "2" "2" "2" "658" "73.8" "6.33" "3.68" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10996, Pf16661, Pf21382" "55756" "ENSG00000104299" "INTS9" "B7Z560; B7Z6M5; hsa:55756; O00224; Q8TB16; Q9NV88" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643630707960143102" "False" "High" "IsMasterProtein" "Q4KWH8" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" "0.000" "False" "5.391" "0" "1" "7" "1" "1693" "189.1" "7.74" "16.84" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23007" "ENSG00000114805" "PLCH1" "hsa:23007; Q29RV9; Q4KWH8; Q4KWH9; Q68CN0; Q86XK4; Q9H9U2; Q9UPT3" "Synthesis of IP3 and IP4 in the cytosol" "Mesodermal commitment pathway; GPR40 pathway" "3" "0" "1.126" "0.911" "0.956" "1.076" "0.941" "1.252" "1.065" "0.769" "0.631" "213.4" "240.4" "194.5" "204.1" "229.7" "200.8" "267.2" "227.2" "164.1" "134.6" "" "" "" "" "" "" "" "" "" "" "192.7" "185.4" "150.4" "137.4" "191.6" "171.3" "226.7" "164.4" "110.7" "134.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5044889676122240904" "False" "High" "IsMasterProtein" "Q9H270" "Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1" "0.000" "False" "5.389" "1" "1" "1" "1" "941" "107.8" "7.05" "3.36" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00637, Pf12451, Pf13923" "55823" "" "VPS11" "hsa:55823; Q8WY89; Q96EP8; Q9H270; Q9H6D9; Q9HCS6" "SARS-CoV-2 modulates autophagy" "Network map of SARS-CoV-2 signaling pathway" "2" "0" "1.040" "0.928" "1.013" "0.851" "0.924" "1.032" "0.814" "0.903" "2.195" "46.8" "48.7" "43.4" "47.4" "39.8" "43.2" "48.3" "38.1" "42.3" "102.7" "" "" "" "" "" "" "" "" "" "" "42.2" "37.6" "33.6" "31.9" "33.2" "36.9" "41.0" "27.6" "28.5" "102.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7958389170144649522" "False" "High" "IsMasterProtein" "P45983" "Mitogen-activated protein kinase 8 OS=Homo sapiens OX=9606 GN=MAPK8 PE=1 SV=2" "0.000" "False" "5.389" "4" "2" "4" "1" "427" "48.3" "6.89" "12.54" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5599" "ENSG00000107643" "MAPK8" "B5BTZ5; B7ZLV4; D3DX88; D3DX92; hsa:5599; P45983; Q15709; Q15712; Q15713; Q308M2" "Signaling by ALK fusions and activated point mutants; FCERI mediated MAPK activation; NRAGE signals death through JNK; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; WNT5:FZD7-mediated leishmania damping; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; DSCAM interactions; Activation of BIM and translocation to mitochondria ; Activation of the AP-1 family of transcription factors; NRIF signals cell death from the nucleus; Activation of BMF and translocation to mitochondria; Interleukin-38 signaling" "Osteoclast signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered regulated necrosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; IL-3 signaling pathway; Nod-like receptor (NLR) signaling pathway; Transcriptional activation by NRF2 in response to phytochemicals; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; PDGFR-beta pathway; Wnt signaling in kidney disease; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; Wnt signaling; miRNA role in immune response in sepsis; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; NRF2-ARE regulation; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Signal transduction through IL1R; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Roles of ceramides in development of insulin resistance; IL-26 signaling pathways; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "99" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1783792033634386114" "False" "High" "IsMasterProtein" "Q8N7H5" "RNA polymerase II-associated factor 1 homolog OS=Homo sapiens OX=9606 GN=PAF1 PE=1 SV=2" "0.000" "False" "5.383" "3" "2" "2" "2" "531" "59.9" "4.63" "6.56" "2" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03985" "54623" "ENSG00000006712" "PAF1" "hsa:54623; M0QX35; O75239; Q8N7H5; Q9H166; Q9NUU9" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins" "Endoderm differentiation" "5" "0" "1.133" "1.231" "1.003" "0.749" "1.002" "0.833" "0.091" "1.336" "11.600" "39.0" "44.1" "48.0" "39.1" "29.2" "39.1" "32.5" "3.5" "52.1" "452.0" "" "" "" "" "" "" "" "" "" "" "35.2" "34.1" "37.1" "26.3" "24.3" "33.3" "27.5" "2.6" "35.1" "452.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7021380242978739287" "False" "High" "IsMasterProtein" "Q92797" "Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2" "0.000" "False" "5.381" "1" "2" "2" "2" "1274" "141.1" "6.13" "5.69" "2" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf11935, Pf12295" "8189" "ENSG00000125755" "SYMPK" "hsa:8189; O00521; O00689; O00733; Q59GT5; Q8N2U5; Q92797" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4503550903694701286" "False" "High" "IsMasterProtein" "O60504" "Vinexin OS=Homo sapiens OX=9606 GN=SORBS3 PE=1 SV=2" "0.000" "False" "5.381" "4" "2" "2" "2" "671" "75.3" "9.45" "5.02" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00018, Pf02208, Pf14604" "10174" "ENSG00000120896" "SORBS3" "hsa:10174; O60504; Q5BJE4; Q6NX54; Q96FY4; Q9UQE4" "Smooth Muscle Contraction" "" "1" "0" "1.054" "0.963" "1.049" "0.794" "0.826" "0.723" "0.716" "0.778" "1.072" "36.8" "38.8" "35.4" "38.6" "29.2" "30.4" "26.6" "26.3" "28.6" "39.4" "" "" "" "" "" "" "" "" "" "" "33.2" "29.9" "27.4" "26.0" "24.4" "25.9" "22.6" "19.0" "19.3" "39.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076863243069163850" "False" "High" "IsMasterProtein" "Q8WX93" "Palladin OS=Homo sapiens OX=9606 GN=PALLD PE=1 SV=3" "0.000" "False" "5.381" "2" "2" "3" "2" "1383" "150.5" "7.09" "2.34" "2" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf07679" "23022" "ENSG00000129116" "PALLD" "B3KTG2; B5MD56; B7ZMM5; hsa:23022; Q7L3E0; Q7Z3W0; Q86WE8; Q8N1M2; Q8WX93; Q9UGA0; Q9UQF5; Q9Y2J6; Q9Y3E9" "" "" "0" "0" "0.827" "0.813" "0.577" "0.770" "0.834" "0.749" "0.978" "0.877" "1.270" "38.3" "31.7" "31.1" "22.1" "29.5" "32.0" "28.7" "37.5" "33.6" "48.7" "" "" "" "" "" "" "" "" "" "" "34.6" "24.5" "24.1" "14.9" "24.6" "27.3" "24.4" "27.1" "22.7" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3917086936507081280" "False" "High" "IsMasterProtein" "Q56P03" "E2F-associated phosphoprotein OS=Homo sapiens OX=9606 GN=EAPP PE=1 SV=4" "0.000" "False" "5.381" "3" "1" "1" "1" "285" "32.7" "5.12" "3.63" "1" "other biological processes" "nucleus;other cell component" "" "Pf10238" "55837" "ENSG00000129518" "EAPP" "hsa:55837; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86" "" "" "0" "0" "0.911" "0.883" "0.867" "0.987" "0.858" "0.986" "0.833" "0.915" "1.174" "164.7" "150.1" "145.4" "142.8" "162.5" "141.3" "162.4" "137.2" "150.7" "193.4" "" "" "" "" "" "" "" "" "" "" "148.7" "115.8" "112.5" "96.1" "135.6" "120.6" "137.7" "99.3" "101.6" "193.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6462118287367883221" "False" "High" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "0.000" "False" "5.376" "11" "3" "3" "3" "219" "24.3" "6.21" "4.83" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6953685933096655099" "False" "High" "IsMasterProtein" "Q8N465" "D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3" "0.000" "False" "5.369" "5" "3" "3" "3" "521" "56.4" "7.99" "8.12" "3" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01565, Pf02913" "728294" "ENSG00000180902" "D2HGDH" "B4E3L6; E7ENP2; hsa:728294; Q6IQ24; Q8N465; Q8N5Q8" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2q37 copy number variation syndrome" "2" "0" "0.883" "1.172" "1.043" "1.118" "1.089" "1.146" "1.076" "1.370" "0.877" "130.7" "115.4" "153.2" "136.3" "146.1" "142.3" "149.7" "140.6" "179.0" "114.5" "" "" "" "" "" "" "" "" "" "" "118.0" "89.0" "118.5" "91.8" "121.9" "121.4" "127.0" "101.7" "120.7" "114.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173769377935829106" "False" "High" "IsMasterProtein" "Cont_P15497" "Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3" "0.000" "True" "5.369" "6" "2" "2" "2" "265" "30.3" "5.97" "6.24" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf01442" "281631" "ENSBIXG00000010441; ENSBIXG00005004093; ENSBTAG00000002258" "APOA1" "A0A4W2DWW2; A5D7M9; bta:281631; P15497; Q3SZD9; V6F9A2" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors" "Statin pathway; Folate metabolism; Vitamin B12 metabolism; Selenium micronutrient network" "15" "0" "0.750" "0.787" "0.917" "0.833" "0.965" "0.794" "0.797" "1.043" "0.620" "187.5" "140.6" "147.5" "171.8" "156.2" "180.9" "148.9" "149.4" "195.5" "116.2" "" "" "" "" "" "" "" "" "" "" "169.2" "108.5" "114.1" "115.7" "130.3" "154.4" "126.3" "108.1" "131.9" "116.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7374659774527651574" "False" "High" "IsMasterProtein" "Q5T5P2" "Sickle tail protein homolog OS=Homo sapiens OX=9606 GN=KIAA1217 PE=1 SV=2" "0.000" "False" "5.356" "1" "1" "1" "1" "1943" "214.0" "7.06" "3.12" "1" "developmental processes" "cytoskeleton;other cell component" "" "Pf03915" "56243" "ENSG00000120549" "KIAA1217" "A5LHW9; A6NLF3; A6PVQ5; A6PVQ6; A6PVQ7; B9EGK4; hsa:56243; Q4KMG4; Q5T5P2; Q5T5P3; Q5T7H3; Q6MZZ6; Q6ZUI4; Q8WV45; Q9NSR2; Q9ULK3" "" "" "0" "0" "0.785" "0.906" "0.966" "0.967" "0.992" "1.092" "1.054" "1.228" "1.582" "27.2" "21.4" "24.7" "26.3" "26.3" "27.0" "29.7" "28.7" "33.4" "43.1" "" "" "" "" "" "" "" "" "" "" "24.6" "16.5" "19.1" "17.7" "22.0" "23.0" "25.2" "20.8" "22.5" "43.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945964816553277045" "False" "High" "IsMasterProtein" "Q9Y2X0" "Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2" "0.000" "False" "5.349" "2" "2" "2" "2" "877" "96.7" "7.37" "5.87" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00400, Pf11635, Pf20718, Pf20719" "10025" "ENSG00000175221" "MED16" "hsa:10025; Q6PJT2; Q96AD4; Q96I35; Q9Y2X0; Q9Y652" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.028" "0.978" "1.081" "0.986" "0.889" "1.058" "1.043" "1.021" "1.040" "312.5" "321.3" "305.6" "337.8" "308.0" "277.8" "330.6" "325.9" "319.2" "325.0" "" "" "" "" "" "" "" "" "" "" "282.1" "247.8" "236.4" "227.4" "257.0" "237.1" "280.5" "235.8" "215.3" "325.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6359108141380896600" "False" "High" "IsMasterProtein" "Q86W50" "RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2" "0.000" "False" "5.346" "2" "1" "1" "1" "562" "63.6" "7.85" "3.51" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05971" "79066" "ENSG00000127804" "METTL16" "D3DTI8; hsa:79066; Q86TE5; Q86W50; Q96T16; Q9BVG7" "" "" "0" "0" "1.006" "0.872" "1.060" "1.132" "0.763" "1.139" "0.972" "0.774" "1.462" "220.7" "222.1" "192.5" "233.9" "249.9" "168.4" "251.5" "214.5" "170.7" "322.6" "" "" "" "" "" "" "" "" "" "" "199.2" "171.3" "148.9" "157.5" "208.5" "143.7" "213.3" "155.2" "115.2" "322.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534068984681137235" "False" "High" "IsMasterProtein" "Q86WQ0" "Nuclear receptor 2C2-associated protein OS=Homo sapiens OX=9606 GN=NR2C2AP PE=1 SV=1" "0.000" "False" "5.343" "17" "1" "1" "1" "139" "15.9" "6.16" "5.39" "1" "" "nucleus" "" "" "126382" "ENSG00000184162" "NR2C2AP" "A6NGP7; B4DW92; hsa:126382; Q86WQ0" "Nuclear Receptor transcription pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396940342238216990" "False" "High" "IsMasterProtein" "Q9H6Y2" "WD repeat-containing protein 55 OS=Homo sapiens OX=9606 GN=WDR55 PE=1 SV=2" "0.000" "False" "5.343" "5" "2" "2" "2" "383" "42.0" "4.92" "6.09" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf12894" "54853" "ENSG00000120314" "WDR55" "hsa:54853; Q9H6Y2; Q9NXK4" "" "" "0" "0" "1.102" "0.816" "0.908" "1.187" "0.933" "0.953" "0.981" "0.808" "0.899" "67.3" "74.2" "54.9" "61.1" "79.9" "62.8" "64.1" "66.0" "54.4" "60.5" "" "" "" "" "" "" "" "" "" "" "60.8" "57.3" "42.5" "41.2" "66.7" "53.6" "54.4" "47.8" "36.7" "60.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7773792101669392702" "False" "High" "IsMasterProtein" "O94880" "PHD finger protein 14 OS=Homo sapiens OX=9606 GN=PHF14 PE=1 SV=3" "0.000" "False" "5.326" "1" "1" "1" "1" "948" "106.9" "5.34" "4.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf13831, Pf13832" "9678" "ENSG00000106443" "PHF14" "A0A0U1RRH6; A7MCZ3; B4DI82; hsa:9678; O94880" "" "" "0" "0" "1.087" "1.849" "1.081" "1.029" "1.995" "0.953" "1.007" "2.071" "2.510" "98.2" "106.7" "181.5" "106.2" "101.0" "195.8" "93.5" "98.9" "203.3" "246.5" "" "" "" "" "" "" "" "" "" "" "88.6" "82.3" "140.4" "71.5" "84.3" "167.1" "79.3" "71.6" "137.1" "246.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1707703891335855171" "False" "High" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "0.000" "False" "5.319" "2" "3" "3" "3" "1369" "155.1" "8.09" "5.07" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "" "VEGFA-VEGFR2 signaling" "1" "0" "0.983" "1.071" "1.035" "0.829" "0.921" "0.945" "1.056" "1.010" "0.920" "76.2" "74.9" "81.5" "78.9" "63.1" "70.2" "72.0" "80.4" "77.0" "70.0" "" "" "" "" "" "" "" "" "" "" "68.7" "57.7" "63.1" "53.1" "52.7" "59.9" "61.1" "58.2" "51.9" "70.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4527223765443096832" "False" "High" "IsMasterProtein" "O95785" "Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ PE=1 SV=2" "0.000" "False" "5.318" "1" "1" "1" "1" "1651" "178.6" "6.86" "3.54" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "58525" "ENSG00000011451" "WIZ" "B3KVH1; B7ZM82; hsa:58525; M0QY21; O95785; Q4G0E0; Q6P6B0; Q6ZN24; Q7LDY6; Q7LDZ1; Q96IG5; Q96SQ6; Q9BUR8; Q9NPT1" "" "" "0" "0" "0.845" "1.111" "1.059" "0.967" "0.974" "0.937" "1.194" "1.107" "0.923" "47.0" "39.7" "52.2" "49.7" "45.4" "45.7" "44.0" "56.1" "52.0" "43.4" "" "" "" "" "" "" "" "" "" "" "42.4" "30.6" "40.4" "33.5" "37.9" "39.0" "37.3" "40.6" "35.1" "43.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7167041566668473319" "False" "High" "IsMasterProtein" "Q96RK0" "Protein capicua homolog OS=Homo sapiens OX=9606 GN=CIC PE=1 SV=3" "0.000" "False" "5.313" "1" "2" "2" "2" "2517" "257.9" "8.10" "5.24" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf16090" "23152" "ENSG00000079432" "CIC" "A0A7P0T9K5" "" "" "0" "0" "1.129" "2.201" "1.114" "1.367" "1.627" "1.192" "1.320" "1.689" "2.300" "38.4" "43.3" "84.5" "42.8" "52.5" "62.4" "45.7" "50.6" "64.8" "88.2" "" "" "" "" "" "" "" "" "" "" "34.6" "33.4" "65.3" "28.8" "43.8" "53.3" "38.8" "36.6" "43.7" "88.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2730791661393038830" "False" "High" "IsMasterProtein" "Q9Y3P8" "Signaling threshold-regulating transmembrane adapter 1 OS=Homo sapiens OX=9606 GN=SIT1 PE=1 SV=1" "0.000" "False" "5.310" "10" "1" "1" "1" "196" "21.1" "6.30" "3.67" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "" "27240" "ENSG00000137078" "SIT1" "B2RBP9; hsa:27240; Q9Y3P8" "" "" "0" "0" "0.892" "0.902" "0.959" "1.011" "0.902" "0.918" "1.002" "0.987" "0.734" "52.7" "47.0" "47.5" "50.5" "53.2" "47.5" "48.3" "52.7" "52.0" "38.6" "" "" "" "" "" "" "" "" "" "" "47.5" "36.2" "36.7" "34.0" "44.4" "40.5" "41.0" "38.2" "35.0" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1759740052719989179" "False" "High" "IsMasterProtein" "O14561" "Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3" "0.000" "False" "5.308" "13" "2" "3" "2" "156" "17.4" "4.93" "8.91" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "translation activity;other molecular function" "Pf00550" "4706" "ENSG00000004779" "NDUFAB1" "B2R4M1; O14561; Q9UNV1" "Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "7" "0" "0.971" "1.519" "1.350" "0.878" "1.607" "1.912" "1.515" "1.470" "0.934" "200.9" "195.1" "305.2" "271.2" "176.3" "323.0" "384.2" "304.4" "295.4" "187.6" "" "" "" "" "" "" "" "" "" "" "181.4" "150.5" "236.0" "182.7" "147.1" "275.7" "325.9" "220.3" "199.2" "187.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2508229497243424265" "False" "High" "IsMasterProtein" "P82673" "Small ribosomal subunit protein mS35 OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" "0.000" "False" "5.307" "9" "3" "3" "3" "323" "36.8" "8.24" "7.13" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10213" "60488" "ENSG00000061794" "MRPS35" "hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.856" "0.791" "0.936" "0.934" "0.818" "0.827" "0.829" "0.808" "1.043" "274.4" "234.7" "216.9" "256.9" "256.2" "224.5" "227.0" "227.5" "221.7" "286.1" "" "" "" "" "" "" "" "" "" "" "247.7" "181.0" "167.8" "173.0" "213.8" "191.6" "192.5" "164.7" "149.5" "286.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549685978582378632" "False" "High" "IsMasterProtein" "Q9Y399" "Small ribosomal subunit protein uS2m OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "0.000" "False" "5.306" "6" "2" "2" "2" "296" "33.2" "9.26" "5.07" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "4" "0" "0.899" "0.897" "0.910" "0.917" "0.690" "0.910" "0.944" "0.698" "1.235" "43.3" "39.0" "38.9" "39.4" "39.7" "29.9" "39.4" "40.9" "30.2" "53.5" "" "" "" "" "" "" "" "" "" "" "39.1" "30.0" "30.1" "26.6" "33.2" "25.5" "33.4" "29.6" "20.4" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7226470696601852520" "False" "High" "IsMasterProtein" "Q9H0A8" "COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1" "0.000" "False" "5.304" "11" "3" "3" "3" "199" "21.8" "7.31" "8.11" "3" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf07258, Pf21672" "54939" "ENSG00000140365" "COMMD4" "B2RBN4; H3BUL2; hsa:54939; Q7L637; Q9H0A8; Q9NX43" "Neddylation" "" "1" "0" "1.010" "0.967" "0.977" "1.115" "0.966" "1.017" "1.081" "0.975" "1.170" "195.4" "197.4" "188.9" "190.8" "217.9" "188.7" "198.6" "211.2" "190.5" "228.5" "" "" "" "" "" "" "" "" "" "" "176.4" "152.2" "146.1" "128.5" "181.8" "161.0" "168.5" "152.8" "128.5" "228.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "662430967221413337" "False" "High" "IsMasterProtein" "Q8N264" "Rho GTPase-activating protein 24 OS=Homo sapiens OX=9606 GN=ARHGAP24 PE=1 SV=2" "0.000" "False" "5.303" "3" "2" "2" "2" "748" "84.2" "6.67" "3.14" "2" "stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity" "Pf00169, Pf00620" "83478" "ENSG00000138639" "ARHGAP24" "hsa:83478; Q4KMG1; Q6ZNV3; Q86TI5; Q86WE4; Q8N264; Q9H0T6" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle" "Nephrotic syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2062699528790100691" "False" "High" "IsMasterProtein" "Q8WYK2" "Jun dimerization protein 2 OS=Homo sapiens OX=9606 GN=JDP2 PE=1 SV=1" "0.000" "False" "5.296" "6" "1" "2" "1" "163" "18.7" "9.23" "6.47" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "122953" "ENSG00000140044" "JDP2" "hsa:122953; J3KN58; O95430; Q8WYK2; Q9UIE4" "" "" "0" "0" "1.031" "0.923" "0.966" "1.246" "0.954" "1.001" "1.090" "0.812" "0.971" "82.4" "85.0" "76.1" "79.6" "102.7" "78.7" "82.5" "89.8" "66.9" "80.0" "" "" "" "" "" "" "" "" "" "" "74.4" "65.5" "58.8" "53.6" "85.7" "67.1" "70.0" "65.0" "45.2" "80.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1428811385271777844" "False" "High" "IsMasterProtein" "Q9H488" "GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1" "0.000" "False" "5.293" "5" "2" "3" "2" "388" "43.9" "8.53" "4.99" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23509" "ENSG00000101346" "POFUT1" "A8K4R8; E1P5M4; hsa:23509; Q14685; Q5W185; Q9BW76; Q9H488" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "" "1" "0" "0.888" "0.953" "1.315" "1.016" "0.907" "0.972" "1.085" "1.163" "0.820" "34.1" "30.3" "32.5" "44.8" "34.6" "30.9" "33.1" "37.0" "39.6" "27.9" "" "" "" "" "" "" "" "" "" "" "30.8" "23.3" "25.1" "30.2" "28.9" "26.4" "28.1" "26.8" "26.7" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023891521044108187" "False" "High" "IsMasterProtein" "Q96BX8" "MOB kinase activator 3A OS=Homo sapiens OX=9606 GN=MOB3A PE=1 SV=1" "0.000" "False" "5.286" "7" "2" "2" "2" "217" "25.4" "8.63" "5.53" "2" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "126308" "ENSG00000172081" "MOB3A" "B3KTF1; hsa:126308; O75249; Q8TF69; Q96BX8" "" "" "0" "0" "0.754" "0.810" "0.913" "0.777" "0.783" "1.015" "0.748" "0.605" "1.282" "96.7" "73.0" "78.3" "88.3" "75.1" "75.8" "98.2" "72.4" "58.5" "124.0" "" "" "" "" "" "" "" "" "" "" "87.3" "56.3" "60.6" "59.5" "62.7" "64.7" "83.3" "52.4" "39.5" "124.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257899417113298170" "False" "High" "IsMasterProtein" "P78316" "Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3" "0.000" "False" "5.276" "2" "2" "3" "2" "857" "97.6" "7.58" "6.88" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04147" "8602" "ENSG00000087269" "NOP14" "D3DVR6; hsa:8602; P78316; Q7LGI5; Q7Z6K0; Q8TBR6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.240" "4.306" "1.119" "0.936" "3.519" "1.014" "1.009" "4.331" "2.803" "68.0" "84.4" "293.0" "76.1" "63.7" "239.5" "69.0" "68.7" "294.7" "190.7" "" "" "" "" "" "" "" "" "" "" "61.4" "65.1" "226.6" "51.3" "53.1" "204.4" "58.5" "49.7" "198.8" "190.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4009101809611603487" "False" "High" "IsMasterProtein" "Q9NUW8" "Tyrosyl-DNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=TDP1 PE=1 SV=2" "0.000" "False" "5.275" "2" "1" "1" "1" "608" "68.4" "7.65" "4.06" "1" "DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06087" "55775" "ENSG00000042088" "TDP1" "hsa:55775; Q2HXX4; Q86TV8; Q96BK7; Q9NUW8; Q9NZM7; Q9NZM8" "Nonhomologous End-Joining (NHEJ)" "" "1" "0" "0.903" "1.186" "0.905" "0.844" "1.108" "1.070" "0.858" "1.203" "4.689" "81.3" "73.5" "96.4" "73.6" "68.6" "90.1" "87.0" "69.8" "97.8" "381.3" "" "" "" "" "" "" "" "" "" "" "73.4" "56.7" "74.6" "49.6" "57.2" "76.9" "73.8" "50.5" "66.0" "381.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6769080269671987288" "False" "High" "IsMasterProtein" "Q9NVP1" "ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2" "0.000" "False" "5.274" "1" "1" "1" "1" "670" "75.4" "9.50" "3.31" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "8886" "ENSG00000088205" "DDX18" "hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1" "" "" "0" "0" "1.204" "0.934" "1.233" "1.097" "0.992" "1.139" "0.861" "1.141" "1.222" "62.2" "74.9" "58.1" "76.7" "68.2" "61.7" "70.8" "53.5" "71.0" "76.0" "" "" "" "" "" "" "" "" "" "" "56.1" "57.7" "44.9" "51.6" "56.9" "52.6" "60.1" "38.7" "47.9" "76.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1962544655148758053" "False" "High" "IsMasterProtein" "P35240" "Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1" "0.000" "False" "5.271" "3" "2" "2" "2" "595" "69.6" "6.47" "6.07" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4771" "ENSG00000186575" "NF2" "hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4" "Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs" "Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma" "10" "0" "1.099" "0.982" "1.231" "1.006" "0.995" "1.059" "0.867" "1.112" "0.791" "136.0" "149.5" "133.5" "167.3" "136.8" "135.2" "144.0" "117.8" "151.2" "107.6" "" "" "" "" "" "" "" "" "" "" "122.7" "115.3" "103.3" "112.7" "114.1" "115.4" "122.1" "85.3" "102.0" "107.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6104701307196402264" "False" "High" "IsMasterProtein" "Q96PE3" "Inositol polyphosphate-4-phosphatase type I A OS=Homo sapiens OX=9606 GN=INPP4A PE=1 SV=1" "0.000" "False" "5.253" "2" "2" "2" "2" "977" "109.9" "6.96" "5.86" "2" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "" "3631" "ENSG00000040933" "INPP4A" "hsa:3631; O15326; Q13187; Q53TD8; Q8TC02; Q96PE3" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "Insulin signaling" "4" "0" "1.135" "0.691" "1.183" "0.942" "0.738" "0.930" "1.231" "0.932" "0.794" "53.2" "60.3" "36.7" "62.9" "50.1" "39.2" "49.4" "65.4" "49.5" "42.2" "" "" "" "" "" "" "" "" "" "" "48.0" "46.5" "28.4" "42.4" "41.8" "33.5" "41.9" "47.4" "33.4" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1688448728000248200" "False" "High" "IsMasterProtein" "Q9BZH6" "WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1" "0.000" "False" "5.250" "2" "3" "6" "3" "1224" "136.6" "6.92" "11.99" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "55717" "ENSG00000120008" "WDR11" "hsa:55717; Q5VWA1; Q9BZH6; Q9P2J6" "RHOH GTPase cycle" "" "1" "0" "1.001" "1.172" "0.973" "0.930" "1.069" "1.060" "1.120" "1.027" "0.733" "402.4" "403.0" "471.5" "391.6" "374.5" "430.1" "426.4" "450.7" "413.2" "295.1" "" "" "" "" "" "" "" "" "" "" "363.3" "310.8" "364.7" "263.7" "312.4" "367.1" "361.7" "326.1" "278.7" "295.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "203506742472389879" "False" "High" "IsMasterProtein" "Q5RL73" "RNA-binding protein 48 OS=Homo sapiens OX=9606 GN=RBM48 PE=1 SV=1" "0.000" "False" "5.244" "3" "1" "1" "1" "367" "41.8" "8.72" "3.92" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "" "84060" "ENSG00000127993" "RBM48" "B7Z2K5; B7ZL51; hsa:84060; Q5H9T2; Q5RL73; Q8IYW7; Q96NS0; Q9H0V7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740288424381142174" "False" "High" "IsMasterProtein" "O43181" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS4 PE=1 SV=1" "0.000" "False" "5.243" "5" "1" "1" "1" "175" "20.1" "10.30" "3.58" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf04800" "4724" "ENSG00000164258" "NDUFS4" "hsa:4724; O43181; Q9BS69" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.969" "1.370" "0.956" "0.972" "1.394" "0.878" "1.126" "1.435" "0.266" "77.0" "74.6" "105.5" "73.6" "74.8" "107.3" "67.6" "86.7" "110.5" "20.5" "" "" "" "" "" "" "" "" "" "" "69.5" "57.6" "81.6" "49.5" "62.4" "91.6" "57.3" "62.7" "74.5" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4874402221689570626" "False" "High" "IsMasterProtein" "Q86W56" "Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1" "0.000" "False" "5.241" "3" "3" "3" "3" "976" "111.0" "6.43" "6.81" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05028, Pf20811" "670; 8505" "ENSG00000227345" "PARG" "A5YBK3; B2RC24; B4DIU5; B4DYR4; hsa:8505; I6RUV3; Q6E4P6; Q6E4P7; Q7Z742; Q86W56; Q9Y4W7" "POLB-Dependent Long Patch Base Excision Repair" "10q11.21q11.23 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5632561991288096733" "False" "High" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "0.000" "False" "5.234" "2" "2" "2" "2" "1135" "128.1" "7.83" "5.99" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "8" "0" "0.939" "1.216" "1.063" "0.931" "1.071" "0.876" "0.867" "1.182" "1.538" "118.8" "111.6" "144.5" "126.2" "110.6" "127.2" "104.1" "103.0" "140.3" "182.7" "" "" "" "" "" "" "" "" "" "" "107.2" "86.1" "111.7" "85.0" "92.3" "108.6" "88.3" "74.5" "94.7" "182.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3326381896502418123" "False" "High" "IsMasterProtein" "P35712" "Transcription factor SOX-6 OS=Homo sapiens OX=9606 GN=SOX6 PE=1 SV=3" "0.000" "False" "5.218" "2" "2" "2" "2" "828" "91.9" "7.78" "4.66" "2" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "55553" "ENSG00000110693" "SOX6" "hsa:55553; P35712; Q86VX7; Q9BXQ3; Q9BXQ4; Q9BXQ5; Q9H0I8" "Deactivation of the beta-catenin transactivating complex" "NOTCH1 regulation of endothelial cell calcification; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "4" "0" "1.010" "1.016" "0.932" "0.870" "1.026" "1.077" "0.815" "1.056" "1.790" "164.0" "165.6" "166.7" "152.8" "142.7" "168.3" "176.6" "133.6" "173.2" "293.7" "" "" "" "" "" "" "" "" "" "" "148.1" "127.7" "128.9" "102.9" "119.1" "143.7" "149.8" "96.7" "116.8" "293.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6964625045538099576" "False" "High" "IsMasterProtein" "Q9H6R7" "WD repeat and coiled-coil-containing protein OS=Homo sapiens OX=9606 GN=WDCP PE=1 SV=1" "0.000" "False" "5.210" "2" "2" "3" "2" "721" "79.1" "6.70" "7.87" "2" "cell organization and biogenesis" "" "other molecular function" "Pf15390" "80304" "ENSG00000163026" "WDCP" "D6W532; hsa:80304; Q8IYK0; Q9H6R7; Q9HBP5" "Signaling by ALK fusions and activated point mutants" "Mesodermal commitment pathway" "2" "0" "1.061" "0.969" "0.929" "1.089" "0.904" "0.974" "0.963" "0.807" "1.375" "54.4" "57.7" "52.7" "50.5" "59.2" "49.1" "52.9" "52.4" "43.9" "74.8" "" "" "" "" "" "" "" "" "" "" "49.1" "44.5" "40.7" "34.0" "49.4" "41.9" "44.9" "37.9" "29.6" "74.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4027474892696141167" "False" "High" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "0.000" "False" "5.202" "4" "2" "2" "2" "483" "57.7" "9.48" "5.00" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "" "6" "0" "1.006" "1.124" "1.048" "0.944" "1.110" "0.996" "1.021" "1.055" "1.749" "183.8" "185.0" "206.6" "192.7" "173.6" "204.1" "183.1" "187.6" "193.9" "321.5" "" "" "" "" "" "" "" "" "" "" "165.9" "142.7" "159.8" "129.8" "144.8" "174.2" "155.3" "135.8" "130.8" "321.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1189012646270467424" "False" "High" "IsMasterProtein" "Q9H5Q4" "Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1" "0.000" "False" "5.194" "4" "2" "2" "2" "396" "45.3" "9.19" "6.25" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00398" "64216" "ENSG00000162851" "TFB2M" "hsa:64216; Q9H5Q4; Q9H626" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "Energy metabolism; Mitochondrial gene expression" "4" "0" "1.102" "0.925" "1.020" "0.979" "0.894" "1.019" "1.000" "0.816" "1.047" "139.9" "154.2" "129.3" "142.6" "136.9" "125.1" "142.6" "139.9" "114.2" "146.4" "" "" "" "" "" "" "" "" "" "" "126.3" "118.9" "100.0" "96.1" "114.2" "106.8" "121.0" "101.3" "77.0" "146.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-466153880284673871" "False" "High" "IsMasterProtein" "Q12873" "Chromodomain-helicase-DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=CHD3 PE=1 SV=3" "0.000" "False" "5.183" "1" "2" "2" "1" "2000" "226.5" "7.30" "2.68" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1107" "ENSG00000170004" "CHD3" "D3DTQ9; E9PG89; hsa:1107; Q12873; Q9Y4I0" "Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "Effect of progerin on genes involved in progeria" "8" "0" "1.165" "1.740" "1.167" "1.117" "1.335" "1.441" "0.806" "1.812" "3.398" "23.0" "26.7" "39.9" "26.8" "25.6" "30.6" "33.1" "18.5" "41.6" "78.0" "" "" "" "" "" "" "" "" "" "" "20.7" "20.6" "30.9" "18.0" "21.4" "26.1" "28.1" "13.4" "28.1" "78.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476586099519423561" "False" "High" "IsMasterProtein" "Q9UI43" "rRNA methyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=MRM2 PE=1 SV=1" "0.000" "False" "5.176" "7" "2" "2" "2" "246" "27.4" "9.50" "5.36" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf01728" "29960" "ENSG00000122687" "MRM2" "hsa:29960; Q24JR8; Q9UI43" "rRNA modification in the mitochondrion" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "984760743341076196" "False" "High" "IsMasterProtein" "Q9Y547" "Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=IFT25 PE=1 SV=1" "0.000" "False" "5.173" "8" "1" "2" "1" "144" "16.3" "5.03" "5.19" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00754" "51668" "ENSG00000081870" "IFT25" "A6NG57; D3DQ45; hsa:51668; Q9Y547; Q9Y684" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis; Alstrom syndrome" "6" "0" "0.868" "1.175" "0.997" "1.039" "0.981" "0.914" "0.895" "0.971" "0.906" "56.0" "48.6" "65.7" "55.8" "58.2" "54.9" "51.2" "50.1" "54.3" "50.7" "" "" "" "" "" "" "" "" "" "" "50.5" "37.5" "50.8" "37.6" "48.5" "46.9" "43.4" "36.2" "36.6" "50.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1246779234316334068" "False" "High" "IsMasterProtein" "P49773" "Adenosine 5'-monophosphoramidase HINT1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "0.000" "False" "5.171" "13" "2" "6" "2" "126" "13.8" "6.95" "17.47" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "1.013" "0.980" "1.027" "1.043" "1.018" "0.979" "1.033" "1.093" "0.762" "356.9" "361.6" "349.8" "366.5" "372.3" "363.4" "349.5" "368.6" "390.2" "271.8" "" "" "" "" "" "" "" "" "" "" "322.1" "278.9" "270.6" "246.8" "310.5" "310.1" "296.5" "266.8" "263.2" "271.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179011071974481602" "False" "High" "IsMasterProtein" "Q9NWS0" "PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1" "0.000" "False" "5.166" "6" "2" "2" "2" "290" "32.3" "5.14" "5.67" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08190, Pf18201" "55011" "ENSG00000104872" "PIH1D1" "B4DGN7; B4E2X7; hsa:55011; Q9BVL0; Q9NWS0" "" "" "0" "0" "0.875" "0.666" "0.762" "0.846" "0.770" "0.702" "0.682" "0.711" "1.665" "52.0" "45.5" "34.7" "39.6" "44.0" "40.1" "36.5" "35.5" "37.0" "86.6" "" "" "" "" "" "" "" "" "" "" "46.9" "35.1" "26.8" "26.7" "36.7" "34.2" "31.0" "25.7" "24.9" "86.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7283076570857654598" "False" "High" "IsMasterProtein" "Q96F44" "E3 ubiquitin-protein ligase TRIM11 OS=Homo sapiens OX=9606 GN=TRIM11 PE=1 SV=2" "0.000" "False" "5.163" "4" "1" "1" "1" "468" "52.7" "5.69" "3.74" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "81559" "ENSG00000154370" "TRIM11" "A6NKE2; B2RB82; B3KUS3; B4DX88; hsa:81559; Q5VSU1; Q8NCA6; Q96F44; Q9C022" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.931" "0.632" "0.936" "0.590" "0.684" "0.916" "0.876" "0.852" "1.419" "18.3" "17.1" "11.6" "17.1" "10.8" "12.5" "16.8" "16.1" "15.6" "26.0" "" "" "" "" "" "" "" "" "" "" "16.5" "13.2" "9.0" "11.5" "9.0" "10.7" "14.2" "11.6" "10.5" "26.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331965257696457103" "False" "High" "IsMasterProtein" "Q9H467" "CUE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CUEDC2 PE=1 SV=1" "0.000" "False" "5.160" "6" "1" "1" "1" "287" "32.0" "4.81" "4.03" "1" "other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02845" "79004" "ENSG00000107874" "CUEDC2" "D3DR88; hsa:79004; Q9BWG8; Q9H467" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4213076317646871579" "False" "High" "IsMasterProtein" "P16219" "Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADS PE=1 SV=1" "0.000" "False" "5.155" "6" "2" "2" "2" "412" "44.3" "7.99" "2.49" "2" "other metabolic processes" "cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "35" "ENSG00000122971" "ACADS" "hsa:35; P16219; P78331" "Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "6" "0" "1.214" "1.116" "1.232" "1.131" "1.267" "0.979" "1.191" "1.436" "0.857" "15.7" "19.0" "17.5" "19.3" "17.7" "19.8" "15.3" "18.6" "22.5" "13.4" "" "" "" "" "" "" "" "" "" "" "14.1" "14.7" "13.5" "13.0" "14.8" "16.9" "13.0" "13.5" "15.2" "13.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1430598846084428850" "False" "High" "IsMasterProtein" "Q3B726" "DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=POLR1F PE=1 SV=1" "0.000" "False" "5.154" "3" "1" "1" "1" "338" "37.4" "6.98" "3.92" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf03876, Pf17875" "221830" "ENSG00000105849" "POLR1F" "A0PJ45; B7Z724; hsa:221830; Q3B726" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "7" "0" "1.192" "1.414" "1.126" "1.209" "1.649" "1.028" "0.918" "1.592" "1.731" "60.9" "72.5" "86.0" "68.5" "73.6" "100.4" "62.6" "55.9" "96.9" "105.4" "" "" "" "" "" "" "" "" "" "" "54.9" "56.0" "66.5" "46.2" "61.4" "85.7" "53.1" "40.4" "65.3" "105.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1879188943006423964" "False" "High" "IsMasterProtein" "A8MSI8" "LYR motif-containing protein 9 OS=Homo sapiens OX=9606 GN=LYRM9 PE=1 SV=2" "0.000" "False" "5.142" "13" "1" "1" "1" "78" "9.4" "9.66" "3.54" "1" "" "" "" "Pf05347" "201229" "ENSG00000232859" "LYRM9" "A6NJT7; A8MSI8; hsa:201229; Q6X7B8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3067082233610559279" "False" "High" "IsMasterProtein" "Q9Y639" "Neuroplastin OS=Homo sapiens OX=9606 GN=NPTN PE=1 SV=2" "0.000" "False" "5.136" "3" "1" "2" "1" "398" "44.4" "7.99" "5.89" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13927" "27020" "ENSG00000156642" "NPTN" "B2RAL7; B7Z4D3; B7ZLL2; hsa:27020; Q17R52; Q59EJ9; Q6NVX7; Q9Y639; Q9Y640" "GABA receptor activation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6587954621125457531" "False" "High" "IsMasterProtein" "Q9NVH6" "Trimethyllysine dioxygenase, mitochondrial OS=Homo sapiens OX=9606 GN=TMLHE PE=1 SV=1" "0.000" "False" "5.129" "4" "2" "2" "2" "421" "49.5" "7.72" "5.36" "2" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf02668, Pf06155" "55217" "ENSG00000185973" "TMLHE" "A8K6M9; B4E3R3; hsa:55217; Q5TZB5; Q6IA90; Q8TBT0; Q9NVH6" "Carnitine synthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6957065747657519198" "False" "High" "IsMasterProtein" "P33552" "Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1" "0.000" "False" "5.129" "20" "2" "2" "1" "79" "9.9" "8.46" "6.35" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1164" "ENSG00000123975" "CKS2" "hsa:1164; P33552; Q6FGI9; Q6LET5" "" "Small cell lung cancer" "1" "1" "0.987" "0.824" "0.849" "0.948" "0.781" "0.943" "0.932" "0.818" "1.449" "181.5" "179.1" "149.6" "154.1" "172.1" "141.7" "171.1" "169.2" "148.4" "263.0" "" "" "" "" "" "" "" "" "" "" "163.8" "138.1" "115.7" "103.8" "143.6" "120.9" "145.1" "122.4" "100.1" "263.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6116188343313863326" "False" "High" "IsMasterProtein" "Q6P1L8" "Large ribosomal subunit protein uL14m OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1" "0.000" "False" "5.128" "10" "1" "1" "1" "145" "15.9" "10.24" "3.80" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00238" "64928" "ENSG00000180992" "MRPL14" "B2R575; hsa:64928; Q6P1L8; Q96Q72" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.930" "0.913" "0.832" "0.760" "0.885" "0.735" "0.797" "0.803" "0.792" "49.2" "45.8" "45.0" "40.9" "37.4" "43.6" "36.2" "39.2" "39.5" "39.0" "" "" "" "" "" "" "" "" "" "" "44.4" "35.3" "34.8" "27.6" "31.2" "37.2" "30.7" "28.4" "26.7" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8811736097892922436" "False" "High" "IsMasterProtein" "Q9BZR8" "Apoptosis facilitator Bcl-2-like protein 14 OS=Homo sapiens OX=9606 GN=BCL2L14 PE=1 SV=1" "0.000" "False" "5.127" "5" "2" "2" "2" "327" "36.6" "6.62" "5.69" "2" "other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "" "79370" "ENSG00000121380; ENSG00000281449" "BCL2L14" "A8KAD0; hsa:79370; Q96QR5; Q9BZR7; Q9BZR8" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "Regulation of apoptosis by parathyroid hormone-related protein" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2487985857359002276" "False" "High" "IsMasterProtein" "Q8IWU2" "Serine/threonine-protein kinase LMTK2 OS=Homo sapiens OX=9606 GN=LMTK2 PE=1 SV=2" "0.000" "False" "5.122" "1" "1" "1" "1" "1503" "164.8" "4.48" "3.40" "1" "protein metabolism;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf07714" "22853" "ENSG00000164715" "LMTK2" "A4D272; hsa:22853; Q75MG7; Q8IWU2; Q9UPS3" "" "" "0" "0" "0.992" "0.821" "0.934" "0.909" "0.732" "0.958" "1.251" "0.981" "1.009" "34.6" "34.4" "28.5" "32.3" "31.5" "25.3" "33.2" "43.3" "34.0" "35.0" "" "" "" "" "" "" "" "" "" "" "31.3" "26.5" "22.0" "21.8" "26.3" "21.6" "28.2" "31.4" "22.9" "35.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-293732230676877255" "False" "High" "IsMasterProtein" "P01909" "HLA class II histocompatibility antigen, DQ alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DQA1 PE=1 SV=1" "0.000" "False" "5.114" "7" "1" "1" "1" "254" "27.8" "5.72" "4.05" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00993, Pf07654" "3117" "ENSG00000196735; ENSG00000206305; ENSG00000232062" "HLA-DQA1" "hsa:3117; O19630; O19706; P01907; P01908; P01909; P04225; P04226; P05536; P79553; Q06751; Q29876; Q29994; Q2Q6Y6; Q2Q6Y7; Q2Q6Y8; Q2WCM3; Q30064; Q30067; Q30068; Q30070; Q30071; Q30072; Q30073; Q30086; Q30101; Q5Y7D5; Q5Y7F5; Q6ICU6; Q6PR46; Q6QDB1; Q860W2; Q860W4; Q9BD37; Q9TPM3; Q9UM31" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host" "10" "0" "1.005" "1.254" "1.252" "1.049" "0.987" "1.125" "1.138" "1.237" "0.965" "21.7" "21.8" "27.2" "27.1" "22.7" "21.4" "24.4" "24.6" "26.8" "20.9" "" "" "" "" "" "" "" "" "" "" "19.6" "16.8" "21.0" "18.3" "18.9" "18.2" "20.7" "17.8" "18.1" "20.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053740260663860944" "False" "High" "IsMasterProtein" "Q9NZN8" "CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1" "0.000" "False" "5.113" "3" "2" "2" "2" "540" "59.7" "7.66" "5.65" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04153" "4848" "ENSG00000111596" "CNOT2" "hsa:4848; Q9H3E0; Q9NSX5; Q9NWR6; Q9NZN8; Q9P028" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914895012756735579" "False" "High" "IsMasterProtein" "P08240" "Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2" "0.000" "False" "5.109" "2" "2" "2" "2" "638" "69.8" "8.95" "5.61" "2" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00448, Pf02881, Pf04086" "6734" "ENSG00000182934" "SRPRA" "A6NIB3; B2R5Z8; B4E0H3; E9PJS4; hsa:6734; P08240; Q9BVJ4" "XBP1(S) activates chaperone genes; SRP-dependent cotranslational protein targeting to membrane" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1831156275587946455" "False" "High" "IsMasterProtein" "Q7Z401" "C-myc promoter-binding protein OS=Homo sapiens OX=9606 GN=DENND4A PE=1 SV=2" "0.000" "False" "5.103" "1" "2" "2" "2" "1863" "209.1" "7.31" "5.50" "2" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf02141, Pf03455, Pf03456" "10260" "ENSG00000174485" "DENND4A" "E7EPL3; hsa:10260; Q14655; Q7Z401; Q86T77; Q8IVX2; Q8NB93" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "1.168" "0.674" "1.002" "1.091" "0.937" "0.944" "0.825" "1.247" "2.092" "50.1" "58.6" "33.8" "50.2" "54.7" "47.0" "47.3" "41.3" "62.5" "104.9" "" "" "" "" "" "" "" "" "" "" "45.3" "45.2" "26.1" "33.8" "45.6" "40.1" "40.1" "29.9" "42.2" "104.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7551679411334968012" "False" "High" "IsMasterProtein" "Q15649" "Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2" "0.000" "False" "5.099" "10" "2" "2" "2" "155" "17.6" "5.67" "5.85" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438, Pf21373" "9326" "ENSG00000273611; ENSG00000278574" "ZNHIT3" "A8K493; hsa:9326; K7EQP1; Q15649; Q8WVJ3" "" "17q12 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2612054938348296953" "False" "High" "IsMasterProtein" "Q16595" "Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2" "0.000" "False" "5.093" "5" "1" "1" "1" "210" "23.1" "8.69" "2.73" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01491" "2395" "ENSG00000165060" "FXN" "A8MXJ6; C9JJ89; hsa:2395; O15545; O95656; Q15294; Q16595; Q5VZ01" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "Iron-sulfur cluster biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3091495107374211726" "False" "High" "IsMasterProtein" "Q9H501" "ESF1 homolog OS=Homo sapiens OX=9606 GN=ESF1 PE=1 SV=1" "0.000" "False" "5.092" "2" "2" "2" "2" "851" "98.7" "5.11" "5.16" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf08159" "51575" "ENSG00000089048" "ESF1" "hsa:51575; Q86X92; Q9H501; Q9H9Q5; Q9HA35; Q9NX93; Q9P1S6" "" "" "0" "0" "1.291" "3.244" "1.424" "1.098" "3.469" "1.096" "1.002" "3.606" "2.714" "46.9" "60.6" "152.2" "66.8" "51.5" "162.8" "51.5" "47.0" "169.2" "127.4" "" "" "" "" "" "" "" "" "" "" "42.4" "46.7" "117.7" "45.0" "43.0" "139.0" "43.6" "34.0" "114.1" "127.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1681183959761710458" "False" "High" "IsMasterProtein" "Q96G28" "Cilia- and flagella-associated protein 36 OS=Homo sapiens OX=9606 GN=CFAP36 PE=1 SV=2" "0.000" "False" "5.091" "3" "1" "1" "1" "342" "39.4" "4.97" "3.60" "1" "" "cytoskeleton;nucleus;other cell component" "" "Pf11527" "112942" "ENSG00000163001" "CFAP36" "hsa:112942; Q53SF0; Q53ST9; Q6UY34; Q96G28" "" "" "0" "0" "1.060" "1.935" "0.951" "0.964" "1.678" "1.156" "0.814" "1.942" "1.712" "49.4" "52.4" "95.7" "47.0" "47.6" "82.9" "57.1" "40.2" "96.0" "84.7" "" "" "" "" "" "" "" "" "" "" "44.6" "40.4" "74.0" "31.6" "39.7" "70.8" "48.5" "29.1" "64.8" "84.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1010665989767425721" "False" "High" "IsMasterProtein" "Q96CS3" "FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2" "0.000" "False" "5.089" "2" "1" "1" "1" "445" "52.6" "5.62" "3.47" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "23197" "ENSG00000113194" "FAF2" "hsa:23197; O94963; Q8IUF2; Q96CS3; Q9BRP2; Q9BVM7" "Neutrophil degranulation; RHOA GTPase cycle" "5q35 copy number variation" "3" "0" "1.159" "1.290" "1.089" "1.270" "1.388" "1.071" "1.123" "1.356" "2.275" "77.8" "90.2" "100.4" "84.7" "98.8" "108.0" "83.3" "87.4" "105.5" "177.0" "" "" "" "" "" "" "" "" "" "" "70.2" "69.5" "77.7" "57.0" "82.4" "92.2" "70.7" "63.3" "71.2" "177.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7703205907594076097" "False" "High" "IsMasterProtein" "Q12982" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=BNIP2 PE=1 SV=1" "0.000" "False" "5.089" "4" "1" "1" "1" "314" "36.0" "4.81" "3.69" "1" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12496, Pf13716" "663" "ENSG00000140299" "BNIP2" "B4DS94; hsa:663; Q12982" "Myogenesis" "Acute viral myocarditis" "2" "0" "1.048" "0.943" "0.946" "1.005" "1.323" "1.052" "0.941" "1.065" "0.941" "32.6" "34.2" "30.7" "30.8" "32.8" "43.1" "34.3" "30.7" "34.7" "30.7" "" "" "" "" "" "" "" "" "" "" "29.4" "26.4" "23.8" "20.8" "27.3" "36.8" "29.1" "22.2" "23.4" "30.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4336688759083416299" "False" "High" "IsMasterProtein" "Q15813" "Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1" "0.000" "False" "5.086" "2" "1" "1" "1" "527" "59.3" "6.76" "3.35" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf14560" "6905" "ENSG00000284770" "TBCE" "A8K8C2; B7Z3P1; Q15813" "Post-chaperonin tubulin folding pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331703410720076251" "False" "High" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "0.000" "False" "5.084" "5" "2" "2" "2" "352" "40.2" "5.47" "5.50" "2" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "Regulation of TNFR1 signaling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "" "2" "0" "1.020" "0.987" "1.023" "0.946" "0.987" "1.002" "1.034" "0.968" "2.027" "111.6" "113.8" "110.1" "114.2" "105.6" "110.2" "111.8" "115.3" "108.0" "226.2" "" "" "" "" "" "" "" "" "" "" "100.7" "87.8" "85.2" "76.9" "88.1" "94.0" "94.9" "83.5" "72.8" "226.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4446297038364687966" "False" "High" "IsMasterProtein" "Q9NPA8" "Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1" "0.000" "False" "5.071" "22" "3" "4" "3" "101" "11.5" "9.33" "10.85" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10163" "56943" "ENSG00000120533" "ENY2" "B2RE52; G3V117; hsa:56943; Q9NPA8" "HATs acetylate histones" "" "1" "0" "1.090" "0.973" "1.003" "1.020" "0.986" "1.117" "1.060" "0.969" "0.853" "194.0" "211.4" "188.8" "194.7" "198.0" "191.3" "216.7" "205.7" "188.0" "165.4" "" "" "" "" "" "" "" "" "" "" "175.1" "163.1" "146.0" "131.1" "165.1" "163.3" "183.8" "148.9" "126.8" "165.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-375580382225270930" "False" "High" "IsMasterProtein" "Q96LI5" "CCR4-NOT transcription complex subunit 6-like OS=Homo sapiens OX=9606 GN=CNOT6L PE=1 SV=2" "0.000" "False" "5.058" "3" "2" "2" "2" "555" "63.0" "6.74" "5.30" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03372, Pf13855" "246175" "ENSG00000138767" "CNOT6L" "hsa:246175; Q96LI5; Q9UF92" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "Ciliary landscape" "4" "0" "1.302" "1.182" "1.381" "1.283" "1.357" "1.194" "1.226" "1.191" "1.747" "59.4" "77.4" "70.2" "82.1" "76.3" "80.7" "71.0" "72.9" "70.8" "103.9" "" "" "" "" "" "" "" "" "" "" "53.7" "59.7" "54.3" "55.3" "63.6" "68.9" "60.2" "52.7" "47.7" "103.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-150019997035989311" "False" "High" "IsMasterProtein" "Q96JK2" "DDB1- and CUL4-associated factor 5 OS=Homo sapiens OX=9606 GN=DCAF5 PE=1 SV=2" "0.000" "False" "5.054" "1" "1" "1" "1" "942" "103.9" "5.76" "3.03" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "8816" "ENSG00000139990" "DCAF5" "B2RN31; G3V4J7; hsa:8816; O60559; Q8N3V3; Q8N3V5; Q96JK2" "Neddylation" "" "1" "0" "0.862" "0.984" "1.018" "0.934" "0.747" "0.942" "0.752" "0.878" "2.764" "40.8" "35.2" "40.2" "41.6" "38.1" "30.5" "38.4" "30.7" "35.8" "112.8" "" "" "" "" "" "" "" "" "" "" "36.8" "27.1" "31.1" "28.0" "31.8" "26.0" "32.6" "22.2" "24.2" "112.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278234146555232268" "False" "High" "IsMasterProtein" "Q96BK5" "PIN2/TERF1-interacting telomerase inhibitor 1 OS=Homo sapiens OX=9606 GN=PINX1 PE=1 SV=2" "0.000" "False" "5.053" "3" "1" "1" "1" "328" "37.0" "9.60" "3.83" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01585" "54984" "ENSG00000254093; ENSG00000284764" "PINX1" "B2R9B1; hsa:54984; Q548A5; Q6QWG9; Q7Z7J8; Q96BK5; Q96QD7; Q9HBU7; Q9NWW2" "" "" "0" "0" "1.110" "1.718" "1.019" "0.978" "1.796" "0.996" "1.041" "2.005" "1.067" "66.3" "73.6" "113.9" "67.5" "64.8" "119.0" "66.0" "69.0" "132.9" "70.7" "" "" "" "" "" "" "" "" "" "" "59.8" "56.8" "88.1" "45.5" "54.1" "101.6" "56.0" "49.9" "89.6" "70.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4045203445570515749" "False" "High" "IsMasterProtein" "Q9BQ49" "Small integral membrane protein 7 OS=Homo sapiens OX=9606 GN=SMIM7 PE=1 SV=2" "0.000" "False" "5.045" "13" "1" "1" "1" "75" "8.6" "8.18" "3.10" "1" "" "other membranes" "" "" "79086" "ENSG00000214046" "SMIM7" "A8MX44; hsa:79086; Q9BQ49" "" "" "0" "0" "1.025" "1.153" "0.892" "1.052" "0.815" "1.112" "1.071" "0.914" "1.105" "63.0" "64.6" "72.6" "56.2" "66.3" "51.4" "70.1" "67.5" "57.6" "69.7" "" "" "" "" "" "" "" "" "" "" "56.9" "49.8" "56.2" "37.9" "55.3" "43.8" "59.5" "48.9" "38.9" "69.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-180619704287479053" "False" "High" "IsMasterProtein" "P01137" "Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=3" "0.000" "False" "5.042" "8" "3" "3" "3" "390" "44.3" "8.53" "7.04" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00019, Pf00688" "7040" "ENSG00000105329" "TGFB1" "A8K792; hsa:7040; P01137; Q9UCG4" "Cell surface interactions at the vascular wall; Transcriptional regulation of white adipocyte differentiation; UCH proteinases; ECM proteoglycans; Platelet degranulation ; Regulation of RUNX3 expression and activity; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; Downregulation of TGF-beta receptor signaling; Molecules associated with elastic fibres; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates p14-ARF; Influenza Virus Induced Apoptosis; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; RUNX3 regulates CDKN1A transcription" "MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell cycle; Allograft rejection; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac progenitor differentiation; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Pluripotent stem cell differentiation pathway; Endoderm differentiation; Dopaminergic neurogenesis; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Lung fibrosis; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Clear cell renal cell carcinoma pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; Nonalcoholic fatty liver disease; Platelet-mediated interactions with vascular and circulating cells; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Signal transduction through IL1R; Envelope proteins and their potential roles in EDMD physiopathology; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; T cell modulation in pancreatic cancer; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Complement system in neuronal development and plasticity; Overview of proinflammatory and profibrotic mediators; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Ulcerative colitis signaling; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Comprehensive IL-17A signaling; Cell interactions of the pancreatic cancer microenvironment; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; 1p36 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; IL-19 signaling pathway; ACE inhibitor pathway; TGF-beta receptor signaling; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "95" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841941710175491915" "False" "High" "IsMasterProtein" "Q5HYK3" "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ5 PE=1 SV=2" "0.000" "False" "5.041" "4" "1" "1" "1" "327" "37.1" "6.95" "3.56" "1" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01209" "84274" "ENSG00000110871" "COQ5" "B2RDU9; B3GK62; B4DEJ4; hsa:84274; Q32Q28; Q53HH0; Q5HYK3; Q96LV1; Q9BSP8" "Ubiquinol biosynthesis" "" "1" "0" "1.278" "0.711" "1.235" "1.168" "0.988" "1.632" "1.242" "1.051" "1.137" "25.9" "33.1" "18.4" "32.0" "30.2" "25.6" "42.3" "32.2" "27.2" "29.4" "" "" "" "" "" "" "" "" "" "" "23.4" "25.5" "14.2" "21.5" "25.2" "21.8" "35.9" "23.3" "18.4" "29.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812205563963537221" "False" "High" "IsMasterProtein" "Q9BSH5" "Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1" "0.000" "False" "5.036" "6" "2" "2" "2" "251" "28.0" "6.71" "5.84" "2" "" "nucleus;other cell component" "" "Pf00702" "81932" "ENSG00000119431" "HDHD3" "B2RD47; hsa:81932; Q9BSH5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327370381573557729" "False" "High" "IsMasterProtein" "Q99611" "Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3" "0.000" "False" "5.035" "6" "2" "2" "2" "448" "47.3" "5.88" "4.64" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22928" "ENSG00000179918" "SEPHS2" "hsa:22928; Q99611; Q9BUQ2" "Selenocysteine synthesis" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "3" "0" "0.621" "0.717" "1.256" "0.753" "0.975" "1.066" "1.190" "0.789" "0.774" "16.0" "9.9" "11.5" "20.1" "12.0" "15.6" "17.1" "19.0" "12.6" "12.4" "" "" "" "" "" "" "" "" "" "" "14.4" "7.7" "8.9" "13.5" "10.1" "13.3" "14.5" "13.8" "8.5" "12.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588774124192242024" "False" "High" "IsMasterProtein" "P54132" "RecQ-like DNA helicase BLM OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1" "0.000" "False" "5.030" "1" "2" "2" "1" "1417" "158.9" "7.49" "5.51" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382, Pf16124, Pf16202, Pf16204" "641" "ENSG00000197299" "BLM" "hsa:641; P54132; Q52M96" "Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Processive synthesis on the C-strand of the telomere" "Primary ovarian insufficiency" "18" "0" "1.902" "3.369" "1.176" "1.371" "3.575" "1.585" "0.904" "3.807" "2.773" "9.1" "17.2" "30.6" "10.7" "12.4" "32.4" "14.4" "8.2" "34.5" "25.1" "" "" "" "" "" "" "" "" "" "" "8.2" "13.3" "23.6" "7.2" "10.4" "27.7" "12.2" "5.9" "23.3" "25.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951655110054191757" "False" "High" "IsMasterProtein" "Q5VW32" "BRO1 domain-containing protein BROX OS=Homo sapiens OX=9606 GN=BROX PE=1 SV=1" "0.000" "False" "5.029" "2" "1" "1" "1" "411" "46.4" "7.65" "4.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;nucleus" "" "Pf03097" "148362" "ENSG00000162819" "BROX" "B7Z9G5; hsa:148362; Q5VW32; Q96MG1" "" "" "0" "0" "0.891" "0.956" "0.877" "0.875" "0.947" "0.959" "0.893" "0.982" "2.290" "125.7" "111.9" "120.2" "110.2" "110.0" "119.0" "120.5" "112.3" "123.4" "287.9" "" "" "" "" "" "" "" "" "" "" "113.5" "86.3" "93.0" "74.2" "91.7" "101.5" "102.2" "81.3" "83.2" "287.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8205566320687520923" "False" "High" "IsMasterProtein" "Q9NSK0" "Kinesin light chain 4 OS=Homo sapiens OX=9606 GN=KLC4 PE=1 SV=3" "0.000" "False" "5.023" "3" "2" "3" "1" "619" "68.6" "6.18" "5.41" "2" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf13374, Pf13424" "89953" "ENSG00000137171" "KLC4" "B3KNY4; B3KPI3; B3KSQ3; B4DME9; hsa:89953; Q66K28; Q96EG6; Q9NSK0" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "6" "0" "0.843" "0.726" "1.002" "0.833" "0.781" "0.883" "1.001" "0.742" "0.967" "90.8" "76.5" "65.9" "90.9" "75.6" "70.9" "80.2" "90.9" "67.4" "87.8" "" "" "" "" "" "" "" "" "" "" "82.0" "59.0" "51.0" "61.2" "63.1" "60.5" "68.0" "65.8" "45.4" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5690407567518484702" "False" "High" "IsMasterProtein" "Q9HCS7" "Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2" "0.000" "False" "5.020" "3" "3" "3" "3" "855" "99.9" "6.23" "7.43" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf13181" "56949" "ENSG00000076924" "XAB2" "hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "Rett syndrome; Nucleotide excision repair in xeroderma pigmentosum" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847329680640326989" "False" "High" "IsMasterProtein" "Q8NDI1" "EH domain-binding protein 1 OS=Homo sapiens OX=9606 GN=EHBP1 PE=1 SV=3" "0.000" "False" "5.014" "1" "1" "1" "1" "1231" "139.9" "5.35" "3.87" "1" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "23301" "ENSG00000115504" "EHBP1" "hsa:23301; O94977; Q53TG7; Q53TV6; Q580X2; Q6NX72; Q6PIT3; Q6QNV2; Q8NDI1; Q9NWI9" "" "Ciliary landscape" "1" "0" "0.919" "1.264" "1.256" "0.966" "1.672" "0.773" "0.942" "1.660" "2.051" "54.4" "50.0" "68.7" "68.3" "52.5" "91.0" "42.0" "51.2" "90.3" "111.5" "" "" "" "" "" "" "" "" "" "" "49.1" "38.5" "53.2" "46.0" "43.8" "77.6" "35.6" "37.1" "60.9" "111.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5378807455886263528" "False" "High" "IsMasterProtein" "Q13740" "CD166 antigen OS=Homo sapiens OX=9606 GN=ALCAM PE=1 SV=2" "0.000" "False" "5.008" "4" "2" "2" "2" "583" "65.1" "6.25" "4.38" "2" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08205, Pf13927" "214" "ENSG00000170017" "ALCAM" "B2RNS3; B4DTU0; hsa:214; O60892; Q13740; Q1HGM8; Q1HGM9; Q6PEY4; Q6ZS95" "L1CAM interactions" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7700866187711353791" "False" "High" "IsMasterProtein" "Q9P0R6" "GSK3B-interacting protein OS=Homo sapiens OX=9606 GN=GSKIP PE=1 SV=2" "0.000" "False" "4.999" "7" "1" "1" "1" "139" "15.6" "4.48" "3.45" "1" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05303" "51527" "ENSG00000100744" "GSKIP" "B3KSZ0; hsa:51527; Q9BST1; Q9NWK0; Q9P0R6" "" "" "0" "0" "1.067" "1.051" "1.097" "1.100" "1.091" "1.031" "0.864" "1.090" "0.885" "107.3" "114.5" "112.8" "117.6" "118.0" "117.0" "110.6" "92.7" "116.9" "94.9" "" "" "" "" "" "" "" "" "" "" "96.8" "88.3" "87.2" "79.2" "98.4" "99.9" "93.8" "67.1" "78.9" "94.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147874032451066507" "False" "High" "IsMasterProtein" "Q15036" "Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1" "0.000" "False" "4.997" "4" "2" "2" "2" "470" "52.9" "7.46" "5.67" "2" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf18116, Pf21271, Pf21273" "9784" "ENSG00000115234" "SNX17" "B4DQM7; hsa:9784; Q15036; Q53HN7; Q6IAS3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658722355380059482" "False" "High" "IsMasterProtein" "Q9UPN4" "Centrosomal protein of 131 kDa OS=Homo sapiens OX=9606 GN=CEP131 PE=1 SV=3" "0.000" "False" "4.997" "1" "1" "1" "1" "1083" "122.1" "8.69" "3.39" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22994" "ENSG00000141577" "CEP131" "A6NHI8; B2RN11; hsa:22994; Q96F50; Q9UPN4" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "1.081" "2.373" "0.938" "0.701" "2.271" "0.905" "0.752" "2.105" "1.681" "21.9" "23.6" "51.9" "20.5" "15.3" "49.7" "19.8" "16.4" "46.0" "36.8" "" "" "" "" "" "" "" "" "" "" "19.7" "18.2" "40.1" "13.8" "12.8" "42.4" "16.8" "11.9" "31.1" "36.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4235790517375748562" "False" "High" "IsMasterProtein" "O43924" "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1" "0.000" "False" "4.994" "13" "1" "1" "1" "150" "17.4" "5.67" "3.21" "1" "other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf05351" "5147" "ENSG00000156973" "PDE6D" "hsa:5147; O43250; O43924" "ARL13B-mediated ciliary trafficking of INPP5E; RAS processing" "Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "4463024331811541084" "False" "High" "IsMasterProtein" "Q15054" "DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2" "0.000" "False" "4.993" "2" "1" "1" "1" "466" "51.4" "9.35" "3.96" "1" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf09507" "10714" "ENSG00000077514" "POLD3" "B7ZAI6; hsa:10714; Q15054; Q32MZ9; Q32N00" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "26" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8876703773954477578" "False" "High" "IsMasterProtein" "O43759" "Synaptogyrin-1 OS=Homo sapiens OX=9606 GN=SYNGR1 PE=1 SV=2" "0.000" "False" "4.990" "5" "1" "1" "1" "233" "25.4" "4.68" "4.56" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01284" "9145" "ENSG00000100321" "SYNGR1" "A6NP69; A8K0E2; hsa:9145; O43757; O43758; O43759; Q53Y02; Q96J56; Q9UGZ4" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3894590141980117731" "False" "High" "IsMasterProtein" "Q9NR55" "Basic leucine zipper transcriptional factor ATF-like 3 OS=Homo sapiens OX=9606 GN=BATF3 PE=1 SV=1" "0.000" "False" "4.986" "18" "1" "1" "1" "127" "14.5" "8.94" "5.38" "1" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "55509" "ENSG00000123685" "BATF3" "hsa:55509; Q9NR55" "" "Pre-implantation embryo; Development of pulmonary dendritic cells and macrophage subsets" "2" "0" "1.205" "0.952" "1.215" "1.294" "0.671" "1.113" "0.905" "1.235" "1.122" "17.3" "20.8" "16.4" "21.0" "22.4" "11.6" "19.2" "15.6" "21.3" "19.4" "" "" "" "" "" "" "" "" "" "" "15.6" "16.1" "12.7" "14.1" "18.6" "9.9" "16.3" "11.3" "14.4" "19.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2014587900474496052" "False" "High" "IsMasterProtein" "Q9P015" "Large ribosomal subunit protein uL15m OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" "0.000" "False" "4.982" "6" "2" "2" "2" "296" "33.4" "10.01" "5.35" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00828" "29088" "ENSG00000137547" "MRPL15" "hsa:29088; Q96Q54; Q9H0Y1; Q9P015" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5661386699023188299" "False" "High" "IsMasterProtein" "Q9Y4B4" "Helicase ARIP4 OS=Homo sapiens OX=9606 GN=RAD54L2 PE=1 SV=4" "0.000" "False" "4.976" "1" "1" "1" "1" "1467" "162.7" "6.09" "2.66" "1" "cell organization and biogenesis" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "23132" "ENSG00000164080" "RAD54L2" "hsa:23132; Q8TB57; Q9BV54; Q9Y4B4" "" "DYRK1A involvement regarding cell proliferation in brain development" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342560622817440014" "False" "High" "IsMasterProtein" "Q96PU8" "KH domain-containing RNA-binding protein QKI OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1" "0.000" "False" "4.974" "3" "1" "1" "1" "341" "37.6" "8.56" "3.66" "1" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16544, Pf16551" "9444" "ENSG00000112531" "QKI" "hsa:9444; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q96PU8; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1" "Signaling by BRAF and RAF1 fusions" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6390113821571435192" "False" "High" "IsMasterProtein" "Q9Y2H1" "Serine/threonine-protein kinase 38-like OS=Homo sapiens OX=9606 GN=STK38L PE=1 SV=3" "0.000" "False" "4.970" "4" "2" "2" "2" "464" "54.0" "6.81" "4.79" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00433" "23012" "ENSG00000211455" "STK38L" "A8K4U0; B4E3J8; hsa:23012; Q8TBX7; Q9Y2H1" "" "Hippo-YAP signaling; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "3" "0" "0.931" "0.708" "0.918" "0.888" "0.905" "0.901" "0.798" "0.942" "4.478" "53.7" "50.0" "38.1" "49.3" "47.7" "48.6" "48.4" "42.9" "50.6" "240.6" "" "" "" "" "" "" "" "" "" "" "48.5" "38.6" "29.4" "33.2" "39.8" "41.5" "41.0" "31.0" "34.1" "240.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990882527068196170" "False" "High" "IsMasterProtein" "Cont_P56652" "Inter-alpha-trypsin inhibitor heavy chain H3 OS=Bos taurus OX=9913 GN=ITIH3 PE=1 SV=2" "0.000" "True" "4.945" "2" "2" "2" "2" "891" "99.5" "5.90" "5.40" "2" "other metabolic processes" "non-structural extracellular" "enzyme regulator activity" "Pf00092, Pf06668, Pf08487" "508355" "ENSBIXG00000030288; ENSBTAG00000007846" "ITIH3" "A0A4W2BJV2; A7MB92; bta:508355; P56652; Q0V8M9" "Platelet degranulation" "" "1" "0" "1.141" "1.409" "0.579" "0.462" "0.920" "0.601" "1.246" "0.705" "0.816" "21.0" "23.9" "29.5" "12.1" "9.7" "19.3" "12.6" "26.1" "14.8" "17.1" "" "" "" "" "" "" "" "" "" "" "18.9" "18.4" "22.8" "8.2" "8.1" "16.5" "10.7" "18.9" "10.0" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699838257049576232" "False" "High" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "0.000" "False" "4.937" "2" "2" "2" "2" "876" "98.4" "9.32" "5.32" "2" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782870004774892945" "False" "High" "IsMasterProtein" "Q15796" "Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1" "0.000" "False" "4.930" "4" "2" "2" "2" "467" "52.3" "6.58" "5.30" "2" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4087" "ENSG00000175387" "SMAD2" "hsa:4087; Q15796" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Ub-specific processing proteases; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; Transcriptional regulation of pluripotent stem cells; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "Cell cycle; AGE/RAGE pathway; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; LDLRAD4 and what we know about it; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; GDNF signaling; Inflammatory bowel disease signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling" "49" "0" "0.876" "0.738" "1.009" "0.953" "0.744" "0.927" "0.883" "0.824" "1.237" "275.0" "240.8" "203.1" "277.6" "262.0" "204.6" "254.9" "242.9" "226.5" "340.0" "" "" "" "" "" "" "" "" "" "" "248.2" "185.7" "157.0" "186.9" "218.5" "174.6" "216.2" "175.8" "152.8" "340.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5402441647647125323" "False" "High" "IsMasterProtein" "O75880" "Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1" "0.000" "False" "4.929" "5" "2" "2" "2" "301" "33.8" "8.88" "5.61" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "6341" "ENSG00000133028" "SCO1" "B2RDM0; hsa:6341; O75880" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis" "5" "0" "0.926" "0.735" "1.071" "1.068" "0.770" "0.901" "0.988" "0.774" "0.611" "205.1" "189.9" "150.8" "219.7" "219.1" "158.0" "184.8" "202.7" "158.8" "125.4" "" "" "" "" "" "" "" "" "" "" "185.2" "146.5" "116.7" "148.0" "182.7" "134.9" "156.8" "146.7" "107.1" "125.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032311727132364318" "False" "High" "IsMasterProtein" "Q8IVV7" "Glucose-induced degradation protein 4 homolog OS=Homo sapiens OX=9606 GN=GID4 PE=1 SV=1" "0.000" "False" "4.920" "3" "1" "1" "1" "300" "33.5" "9.16" "2.97" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf09783" "79018" "ENSG00000141034" "GID4" "hsa:79018; Q8IVV7; Q8TEB5; Q9BW50" "" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8164709769345228762" "False" "High" "IsMasterProtein" "Q9H4Z3" "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase OS=Homo sapiens OX=9606 GN=PCIF1 PE=1 SV=1" "0.000" "False" "4.916" "2" "1" "1" "1" "704" "80.6" "7.42" "3.73" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf12237" "63935" "ENSG00000100982" "PCIF1" "E1P5P1; hsa:63935; Q54AB9; Q9H4Z3; Q9NT85" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7520728591750181120" "False" "High" "IsMasterProtein" "O00625" "Pirin OS=Homo sapiens OX=9606 GN=PIR PE=1 SV=1" "0.000" "False" "4.913" "6" "2" "2" "2" "290" "32.1" "6.92" "4.78" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02678, Pf05726" "8544" "ENSG00000087842" "PIR" "hsa:8544; O00625; Q5U0G0; Q6FHD2" "Digestion" "" "1" "0" "1.265" "1.334" "1.050" "1.163" "1.211" "1.027" "1.195" "1.191" "1.355" "57.8" "73.1" "77.1" "60.7" "67.2" "70.0" "59.4" "69.1" "68.9" "78.3" "" "" "" "" "" "" "" "" "" "" "52.2" "56.4" "59.6" "40.9" "56.1" "59.7" "50.4" "50.0" "46.4" "78.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7754032673472143678" "False" "High" "IsMasterProtein" "Q8TET4" "Neutral alpha-glucosidase C OS=Homo sapiens OX=9606 GN=GANC PE=1 SV=3" "0.000" "False" "4.898" "1" "1" "2" "1" "914" "104.3" "6.23" "6.15" "1" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf01055, Pf13802, Pf21365" "2595" "ENSG00000214013" "GANC" "hsa:2595; Q52LQ4; Q8IWZ0; Q8IZM4; Q8IZM5; Q8TET4" "" "Osteoarthritic chondrocyte hypertrophy" "1" "0" "0.873" "0.958" "0.951" "0.910" "1.116" "0.884" "0.942" "1.104" "0.925" "99.1" "86.5" "95.0" "94.2" "90.2" "110.6" "87.6" "93.3" "109.4" "91.7" "" "" "" "" "" "" "" "" "" "" "89.4" "66.7" "73.4" "63.4" "75.2" "94.4" "74.3" "67.5" "73.8" "91.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7857168411920132290" "False" "High" "IsMasterProtein" "Q9Y5B8" "Nucleoside diphosphate kinase homolog 7 OS=Homo sapiens OX=9606 GN=NME7 PE=1 SV=1" "0.000" "False" "4.886" "6" "2" "3" "2" "376" "42.5" "6.47" "2.94" "2" "other metabolic processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00334" "29922" "ENSG00000143156" "NME7" "A8K3T6; A8MY09; B3KSW9; hsa:29922; Q5TGZ4; Q9Y5B8" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Pyrimidine metabolism; Ciliopathies" "4" "0" "0.972" "1.053" "1.146" "1.036" "0.878" "1.028" "0.864" "1.117" "3.269" "128.8" "125.1" "135.6" "147.6" "133.4" "113.0" "132.3" "111.2" "143.9" "421.0" "" "" "" "" "" "" "" "" "" "" "116.2" "96.5" "104.9" "99.4" "111.3" "96.5" "112.3" "80.5" "97.0" "421.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354305271704446850" "False" "High" "IsMasterProtein" "O95248" "Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4" "0.000" "False" "4.883" "1" "1" "1" "1" "1868" "208.3" "6.90" "3.44" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "6305" "ENSG00000100241" "SBF1" "A0A024R4Z9; A6PVG9; G5E933; hsa:6305; O60228; O95248; Q5JXD8; Q5PPM2; Q96GR9; Q9UGB8" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the ER membrane" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5943857634113699629" "False" "High" "IsMasterProtein" "Q32MK0" "Myosin light chain kinase 3 OS=Homo sapiens OX=9606 GN=MYLK3 PE=1 SV=3" "0.000" "False" "4.881" "3" "2" "4" "1" "819" "88.3" "6.11" "11.14" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf00069" "91807" "ENSG00000140795" "MYLK3" "B5BUL9; B7Z5U8; hsa:91807; Q32MK0; Q32MK1; Q96DV1" "" "MicroRNAs in cardiomyocyte hypertrophy; Cardiac progenitor differentiation; Focal adhesion" "3" "0" "0.983" "0.964" "0.913" "1.021" "1.132" "1.010" "0.950" "1.230" "0.878" "131.3" "129.1" "126.6" "119.9" "134.1" "148.7" "132.6" "124.7" "161.5" "115.3" "" "" "" "" "" "" "" "" "" "" "118.5" "99.6" "97.9" "80.7" "111.9" "126.9" "112.5" "90.2" "109.0" "115.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5611096213630678464" "False" "High" "IsMasterProtein" "P11279" "Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3" "0.000" "False" "4.879" "2" "1" "1" "1" "417" "44.9" "8.75" "4.11" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3916" "ENSG00000185896" "LAMP1" "B4DWL3; hsa:3916; P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4123477520333659496" "False" "High" "IsMasterProtein" "Q7Z4G4" "tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1" "0.000" "False" "4.873" "5" "2" "2" "2" "463" "53.4" "7.78" "5.56" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01170" "60487" "ENSG00000066651" "TRMT11" "E1P570; hsa:60487; Q5JY11; Q6PGQ5; Q7Z4G4; Q9HC13" "tRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974134927255505490" "False" "High" "IsMasterProtein" "Q6VY07" "Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2" "0.000" "False" "4.869" "1" "1" "1" "1" "963" "104.8" "7.74" "3.84" "1" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf10254" "55690" "ENSG00000175115" "PACS1" "hsa:55690; Q6PJY6; Q6PKB6; Q6VY07; Q7Z590; Q7Z5W4; Q8N8K6; Q96MW0; Q9NW92; Q9ULP5" "Nef mediated downregulation of MHC class I complex cell surface expression" "" "1" "0" "0.969" "1.004" "1.186" "0.937" "0.911" "1.051" "1.153" "0.952" "1.162" "40.0" "38.7" "40.2" "47.4" "37.5" "36.4" "42.0" "46.1" "38.1" "46.5" "" "" "" "" "" "" "" "" "" "" "36.1" "29.9" "31.1" "31.9" "31.3" "31.1" "35.7" "33.4" "25.7" "46.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4161818119007266512" "False" "High" "IsMasterProtein" "O43521" "Bcl-2-like protein 11 OS=Homo sapiens OX=9606 GN=BCL2L11 PE=1 SV=1" "0.000" "False" "4.867" "6" "1" "1" "1" "198" "22.2" "8.21" "3.16" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf06773, Pf08945" "10018" "ENSG00000153094" "BCL2L11" "A8K2W2; hsa:10018; O43521; O43522; Q0MSE7; Q0MSE8; Q0MSE9; Q53R28; Q6JTU6; Q6T851; Q6TE14; Q6TE15; Q6TE16; Q6V402; Q8WYL6; Q8WYL7; Q8WYL8; Q8WYL9; Q8WYM0; Q8WYM1" "NRAGE signals death through JNK; Signaling by BRAF and RAF1 fusions; Activation of BIM and translocation to mitochondria ; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes" "Apoptosis modulation and signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced unfolded protein response; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Nonalcoholic fatty liver disease; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Galanin receptor pathway; 2q13 copy number variation syndrome; ErbB signaling pathway; DNA damage response (only ATM dependent)" "24" "0" "1.174" "0.856" "1.098" "1.134" "1.101" "1.120" "1.119" "1.315" "0.684" "52.7" "61.9" "45.2" "57.9" "59.8" "58.1" "59.1" "59.0" "69.3" "36.1" "" "" "" "" "" "" "" "" "" "" "47.6" "47.8" "34.9" "39.0" "49.9" "49.6" "50.1" "42.7" "46.8" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3529380218292263569" "False" "High" "IsMasterProtein" "P05423" "DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2" "0.000" "False" "4.861" "5" "2" "2" "2" "398" "44.4" "6.98" "4.10" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05132" "661" "ENSG00000168495" "POLR3D" "hsa:661; P05423; Q6FI28; Q9BPV7; Q9BPZ1; Q9BXB3" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "0.925" "0.897" "1.178" "1.128" "0.958" "1.212" "1.149" "0.860" "3.468" "31.5" "29.2" "28.3" "37.2" "35.6" "30.2" "38.2" "36.2" "27.1" "109.4" "" "" "" "" "" "" "" "" "" "" "28.5" "22.5" "21.9" "25.0" "29.7" "25.8" "32.4" "26.2" "18.3" "109.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5096502141000675032" "False" "High" "IsMasterProtein" "Q8TBB5" "Kelch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KLHDC4 PE=1 SV=1" "0.000" "False" "4.861" "2" "1" "1" "1" "520" "57.9" "5.72" "2.60" "1" "" "" "" "Pf13415, Pf13418" "54758" "ENSG00000104731" "KLHDC4" "D3DUN3; D3DUN4; D3DUN5; hsa:54758; Q8TBB5; Q96F29; Q9BVN3" "" "" "0" "0" "0.899" "0.940" "1.139" "1.136" "0.858" "1.187" "0.952" "0.941" "2.085" "113.9" "102.4" "107.0" "129.8" "129.4" "97.7" "135.2" "108.4" "107.1" "237.5" "" "" "" "" "" "" "" "" "" "" "102.8" "79.0" "82.8" "87.4" "107.9" "83.4" "114.7" "78.4" "72.3" "237.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2679816748943853066" "False" "High" "IsMasterProtein" "Q9ULH7" "Myocardin-related transcription factor B OS=Homo sapiens OX=9606 GN=MRTFB PE=1 SV=3" "0.000" "False" "4.856" "2" "2" "2" "2" "1088" "118.1" "6.28" "5.67" "2" "other biological processes" "nucleus" "other molecular function" "Pf02037, Pf02755" "57496" "ENSG00000186260" "MRTFB" "A6ND53; B4DGT8; hsa:57496; Q68CT1; Q6UB16; Q86WW2; Q8N226; Q9ULH7" "" "" "0" "0" "1.079" "0.929" "1.098" "1.031" "0.953" "0.950" "1.015" "1.115" "1.030" "95.0" "102.5" "88.3" "104.3" "97.9" "90.5" "90.2" "96.4" "105.9" "97.9" "" "" "" "" "" "" "" "" "" "" "85.7" "79.0" "68.3" "70.2" "81.7" "77.3" "76.5" "69.8" "71.5" "97.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911938199932515837" "False" "High" "IsMasterProtein" "Q9NZQ3" "NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1" "0.000" "False" "4.855" "1" "1" "1" "1" "722" "78.9" "6.38" "3.04" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00018, Pf09431" "51517" "ENSG00000213672" "NCKIPSD" "B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2450286954911087625" "False" "High" "IsMasterProtein" "O43325" "LYR motif-containing protein 1 OS=Homo sapiens OX=9606 GN=LYRM1 PE=1 SV=1" "0.000" "False" "4.855" "7" "1" "1" "1" "122" "14.3" "9.94" "3.97" "1" "" "nucleus;other cell component" "" "Pf05347" "57149" "ENSG00000102897" "LYRM1" "B2R4M5; hsa:57149; O43325" "" "" "0" "0" "0.899" "0.911" "1.127" "0.990" "1.027" "1.025" "0.968" "1.032" "0.685" "167.6" "150.7" "152.8" "188.8" "165.9" "172.1" "171.8" "162.2" "173.1" "114.8" "" "" "" "" "" "" "" "" "" "" "151.3" "116.3" "118.1" "127.2" "138.4" "146.9" "145.7" "117.4" "116.7" "114.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1812058185286656363" "False" "High" "IsMasterProtein" "Q9NWZ8" "Gem-associated protein 8 OS=Homo sapiens OX=9606 GN=GEMIN8 PE=1 SV=1" "0.000" "False" "4.853" "8" "2" "3" "2" "242" "28.6" "6.80" "7.92" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15348" "54960" "ENSG00000046647" "GEMIN8" "C4AMC4; hsa:54960; Q2LJ66; Q6ZV27; Q9NWZ8" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630996109560083637" "False" "High" "IsMasterProtein" "O75909" "Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2" "0.000" "False" "4.852" "3" "2" "2" "2" "580" "64.2" "8.41" "4.34" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf21797" "8812" "ENSG00000090061" "CCNK" "hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "Male infertility" "10" "0" "1.008" "1.104" "1.306" "1.133" "1.038" "1.047" "0.941" "1.126" "0.731" "75.1" "75.7" "82.9" "98.1" "85.1" "78.0" "78.7" "70.7" "84.6" "54.9" "" "" "" "" "" "" "" "" "" "" "67.8" "58.4" "64.1" "66.1" "71.0" "66.6" "66.7" "51.1" "57.1" "54.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479231618500312272" "False" "High" "IsMasterProtein" "Q8NF91" "Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4" "0.000" "False" "4.846" "0" "2" "3" "2" "8797" "1010.5" "5.53" "7.51" "2" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23345" "ENSG00000131018" "SYNE1" "B3W695; E7EQI5; H0Y4C0; O94890; Q3ZCV0; Q5JV19; Q5JV22; Q8N9P7; Q8NF91; Q8TCP1; Q8WWW6; Q8WWW7; Q8WXF6; Q96N17; Q9C0A7; Q9H525; Q9H526; Q9NS36; Q9NU50; Q9UJ06; Q9UJ07; Q9ULF8" "Meiotic synapsis" "Envelope proteins and their potential roles in EDMD physiopathology" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630345377865006626" "False" "High" "IsMasterProtein" "Q9NVS9" "Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1" "0.000" "False" "4.837" "3" "1" "2" "1" "261" "30.0" "7.06" "7.17" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01243, Pf10590" "55163" "ENSG00000108439" "PNPO" "B4E0V0; B4E152; B4E1D7; D3DTT9; hsa:55163; Q9NVS9" "Vitamin B6 activation to pyridoxal phosphate" "Selenium micronutrient network; Vitamin B6-dependent and responsive disorders" "3" "0" "0.888" "0.530" "0.864" "0.757" "0.465" "0.604" "0.494" "0.558" "1.991" "206.6" "183.6" "109.4" "178.6" "156.5" "96.1" "124.8" "102.1" "115.4" "411.5" "" "" "" "" "" "" "" "" "" "" "186.5" "141.6" "84.6" "120.3" "130.6" "82.0" "105.9" "73.9" "77.8" "411.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410624310622087342" "False" "High" "IsMasterProtein" "Q13227" "G protein pathway suppressor 2 OS=Homo sapiens OX=9606 GN=GPS2 PE=1 SV=3" "0.000" "False" "4.834" "3" "1" "1" "1" "327" "36.7" "9.52" "3.26" "1" "stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15991" "2874" "ENSG00000132522; ENSG00000288325" "GPS2" "B4DXA1; hsa:2874; Q13227; Q6FHM8" "HDACs deacetylate histones; PPARA activates gene expression; HCMV Early Events; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "Rett syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741910088829308609" "False" "High" "IsMasterProtein" "Q9NP66" "High mobility group protein 20A OS=Homo sapiens OX=9606 GN=HMG20A PE=1 SV=1" "0.000" "False" "4.830" "5" "2" "2" "2" "347" "40.1" "6.49" "5.80" "2" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505" "10363" "ENSG00000140382" "HMG20A" "A6NHY3; D3DW78; hsa:10363; Q53G31; Q9NP66; Q9NSF6" "" "" "0" "0" "0.840" "0.902" "0.884" "0.793" "1.046" "0.823" "0.687" "1.008" "1.604" "72.0" "60.5" "65.0" "63.7" "57.1" "75.4" "59.3" "49.5" "72.6" "115.6" "" "" "" "" "" "" "" "" "" "" "65.0" "46.6" "50.2" "42.9" "47.7" "64.3" "50.3" "35.8" "49.0" "115.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7004216377696589077" "False" "High" "IsMasterProtein" "Q96DC7" "Transmembrane and coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=TMCO6 PE=1 SV=2" "0.000" "False" "4.821" "2" "1" "1" "1" "493" "54.4" "5.81" "3.91" "1" "transport" "other membranes" "other molecular function" "" "55374" "ENSG00000113119" "TMCO6" "hsa:55374; Q96DC7; Q9BUU0; Q9P198" "" "" "0" "0" "1.021" "1.066" "0.848" "1.095" "1.006" "1.017" "1.496" "1.111" "1.406" "13.7" "14.0" "14.7" "11.7" "15.1" "13.8" "14.0" "20.6" "15.3" "19.3" "" "" "" "" "" "" "" "" "" "" "12.4" "10.8" "11.3" "7.8" "12.6" "11.8" "11.8" "14.9" "10.3" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011686902353610677" "False" "High" "IsMasterProtein" "Q8NBI5" "Equilibrative nucleobase transporter 1 OS=Homo sapiens OX=9606 GN=SLC43A3 PE=1 SV=2" "0.000" "False" "4.820" "2" "1" "1" "1" "491" "54.5" "8.53" "4.03" "1" "transport" "plasma membrane;other membranes" "transporter activity" "" "29015" "ENSG00000134802" "SLC43A3" "B4DNR8; E7EQD2; hsa:29015; Q8NBI5; Q9NSS4" "" "" "0" "0" "1.082" "1.016" "1.036" "1.049" "0.762" "1.162" "1.169" "0.976" "0.646" "244.1" "264.1" "248.0" "252.8" "256.0" "185.9" "283.6" "285.4" "238.3" "157.7" "" "" "" "" "" "" "" "" "" "" "220.4" "203.7" "191.8" "170.2" "213.5" "158.7" "240.6" "206.6" "160.8" "157.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6883226900925947322" "False" "High" "IsMasterProtein" "Q9BW83" "Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1" "0.000" "False" "4.810" "9" "2" "3" "2" "186" "20.5" "5.41" "8.75" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "11020" "ENSG00000100360" "IFT27" "hsa:11020; O60897; Q9BW83" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; GDNF/RET signaling axis; Alstrom syndrome; Bardet-Biedl syndrome" "8" "0" "1.008" "0.997" "1.176" "1.189" "0.914" "1.160" "1.060" "1.240" "0.713" "96.3" "97.1" "96.1" "113.3" "114.5" "88.1" "111.8" "102.1" "119.5" "68.7" "" "" "" "" "" "" "" "" "" "" "87.0" "74.9" "74.3" "76.3" "95.6" "75.2" "94.8" "73.9" "80.6" "68.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5974155710491899055" "False" "High" "IsMasterProtein" "Q9UHD2" "Serine/threonine-protein kinase TBK1 OS=Homo sapiens OX=9606 GN=TBK1 PE=1 SV=1" "0.000" "False" "4.802" "3" "2" "2" "2" "729" "83.6" "6.79" "4.46" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf18394, Pf18396" "29110" "ENSG00000183735" "TBK1" "A8K4S4; hsa:29110; Q8IYV3; Q9NUJ5; Q9UHD2" "IRF3-mediated induction of type I IFN; Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TNFR1-induced proapoptotic signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Interleukin-37 signaling; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN" "TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Toll-like receptor signaling pathway" "35" "0" "1.158" "1.479" "1.057" "1.081" "1.498" "1.085" "1.141" "1.475" "4.462" "12.7" "14.7" "18.8" "13.4" "13.7" "19.0" "13.8" "14.5" "18.7" "56.7" "" "" "" "" "" "" "" "" "" "" "11.5" "11.4" "14.5" "9.1" "11.5" "16.3" "11.7" "10.5" "12.6" "56.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3935713179938084537" "False" "High" "IsMasterProtein" "Q96HP4" "Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1" "0.000" "False" "4.802" "5" "1" "1" "1" "312" "34.8" "8.37" "3.20" "1" "" "" "other molecular function" "Pf00175" "92106" "ENSG00000154814" "OXNAD1" "hsa:92106; Q2HYC7; Q59FA4; Q96HP4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414831155981605711" "False" "High" "IsMasterProtein" "P06703" "Protein S100-A6 OS=Homo sapiens OX=9606 GN=S100A6 PE=1 SV=1" "0.000" "False" "4.794" "17" "2" "3" "2" "90" "10.2" "5.48" "9.62" "2" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf01023" "6277" "ENSG00000197956" "S100A6" "D3DV39; hsa:6277; P06703; Q5RHS4" "" "Gastric cancer network 2; Vitamin D receptor pathway; Prostaglandin synthesis and regulation" "3" "0" "1.016" "1.183" "1.075" "1.019" "1.183" "1.086" "1.087" "1.112" "0.799" "256.2" "260.3" "303.0" "275.5" "261.1" "303.0" "278.2" "278.5" "284.8" "204.7" "" "" "" "" "" "" "" "" "" "" "231.3" "200.8" "234.3" "185.5" "217.8" "258.6" "236.0" "201.6" "192.1" "204.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8315542899134672596" "False" "High" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "0.000" "False" "4.793" "2" "1" "1" "1" "968" "112.1" "6.95" "3.51" "1" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "" "4" "0" "1.132" "3.009" "1.146" "1.381" "2.794" "1.465" "1.191" "3.271" "2.713" "20.7" "23.4" "62.3" "23.7" "28.6" "57.8" "30.3" "24.6" "67.7" "56.1" "" "" "" "" "" "" "" "" "" "" "18.7" "18.1" "48.2" "16.0" "23.8" "49.3" "25.7" "17.8" "45.7" "56.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8030934540585171981" "False" "High" "IsMasterProtein" "Q9UJT0" "Tubulin epsilon chain OS=Homo sapiens OX=9606 GN=TUBE1 PE=1 SV=1" "0.000" "False" "4.786" "2" "1" "1" "1" "475" "52.9" "6.64" "3.54" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "51175" "ENSG00000074935" "TUBE1" "hsa:51175; Q5H8W8; Q8NEG3; Q9UJT0" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "1.073" "0.759" "0.718" "1.190" "0.770" "1.173" "0.915" "0.808" "0.873" "23.6" "25.4" "17.9" "17.0" "28.1" "18.2" "27.7" "21.6" "19.1" "20.6" "" "" "" "" "" "" "" "" "" "" "21.3" "19.6" "13.9" "11.4" "23.5" "15.5" "23.5" "15.7" "12.9" "20.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5224017387005900556" "False" "High" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0.000" "False" "4.785" "0" "2" "2" "2" "3859" "437.3" "8.19" "5.73" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Ub-specific processing proteases; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones" "Rett syndrome" "4" "0" "0.662" "1.109" "1.083" "1.062" "1.004" "0.933" "1.325" "1.361" "1.542" "19.3" "12.8" "21.4" "20.9" "20.5" "19.4" "18.0" "25.6" "26.3" "29.8" "" "" "" "" "" "" "" "" "" "" "17.4" "9.9" "16.6" "14.1" "17.1" "16.5" "15.3" "18.5" "17.7" "29.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631666065222226929" "False" "High" "IsMasterProtein" "P42898" "Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3" "0.000" "False" "4.782" "2" "2" "2" "2" "656" "74.5" "5.34" "6.47" "2" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf02219" "4524" "ENSG00000177000" "MTHFR" "B2R7A6; hsa:4524; P42898; Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2" "Metabolism of folate and pterines" "Glycine metabolism; Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; MTHFR deficiency; Male infertility; Spina bifida" "14" "0" "0.894" "0.975" "1.099" "0.978" "1.046" "1.084" "1.048" "1.069" "1.187" "100.6" "89.9" "98.1" "110.6" "98.4" "105.3" "109.1" "105.4" "107.5" "119.5" "" "" "" "" "" "" "" "" "" "" "90.8" "69.4" "75.9" "74.5" "82.1" "89.8" "92.6" "76.3" "72.5" "119.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4687575668731336676" "False" "High" "IsMasterProtein" "Q6UX04" "Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1" "0.000" "False" "4.765" "5" "2" "2" "2" "472" "53.8" "5.80" "5.07" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00160" "10283" "ENSG00000153015" "CWC27" "hsa:10283; O60529; O60530; Q6UX04; Q96EM3" "mRNA Splicing - Major Pathway" "" "1" "0" "0.899" "1.580" "0.895" "0.985" "1.441" "1.021" "0.977" "1.610" "1.813" "291.9" "262.5" "461.3" "261.3" "287.7" "420.8" "298.1" "285.2" "469.9" "529.3" "" "" "" "" "" "" "" "" "" "" "263.5" "202.5" "356.8" "176.0" "240.0" "359.1" "252.9" "206.4" "317.0" "529.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1466786555444396810" "False" "High" "IsMasterProtein" "Q12933" "TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2" "0.000" "False" "4.747" "3" "2" "3" "2" "501" "55.8" "7.53" "5.34" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf16673, Pf21341, Pf21355" "7186" "ENSG00000127191" "TRAF2" "A8K107; B4DPJ7; hsa:7186; Q12933; Q7Z337; Q96NT2" "Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TRAF6 mediated NF-kB activation; Regulation of NF-kappa B signaling; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; 13q12.12 copy number variation; 8q11.23 (RB1CC1) copy number variation" "37" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405025144750981774" "False" "High" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "0.000" "False" "4.740" "2" "2" "2" "2" "1056" "119.1" "5.64" "5.93" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "" "3" "0" "0.977" "0.953" "1.238" "1.130" "0.916" "1.171" "0.701" "0.868" "6.826" "90.9" "88.9" "86.7" "112.6" "102.8" "83.3" "106.5" "63.7" "79.0" "620.8" "" "" "" "" "" "" "" "" "" "" "82.1" "68.5" "67.0" "75.8" "85.7" "71.1" "90.4" "46.1" "53.3" "620.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317781215487231754" "False" "High" "IsMasterProtein" "P53539" "Protein FosB OS=Homo sapiens OX=9606 GN=FOSB PE=1 SV=1" "0.000" "False" "4.734" "4" "1" "1" "1" "338" "35.9" "4.86" "3.43" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "2354" "ENSG00000125740" "FOSB" "A8K9K5; A8VJE1; A8VJE6; A8VJF0; A8VJF3; A8VJF7; A8VJG1; A8VJG5; A8VJG9; E7EPR6; E9PHJ3; hsa:2354; K7EKC1; K7EMJ6; P53539; Q49AD7" "NGF-stimulated transcription; Estrogen-dependent gene expression" "Corticotropin-releasing hormone signaling pathway; Pre-implantation embryo; TGF-beta signaling pathway; EGF/EGFR signaling pathway; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827521234037792457" "False" "High" "IsMasterProtein" "Q9NUS5" "AP-5 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP5S1 PE=1 SV=1" "0.000" "False" "4.722" "6" "1" "1" "1" "200" "22.5" "6.87" "3.41" "1" "DNA metabolism;stress response;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf15001" "55317" "ENSG00000125843" "AP5S1" "B3KSD0; D3DVY7; hsa:55317; Q9NUS5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-359770206824869393" "False" "High" "IsMasterProtein" "P50747" "Biotin--protein ligase OS=Homo sapiens OX=9606 GN=HLCS PE=1 SV=1" "0.000" "False" "4.717" "3" "2" "2" "2" "726" "80.7" "5.62" "5.33" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02237, Pf03099" "3141" "ENSG00000159267" "HLCS" "B2RAH1; D3DSG6; hsa:3141; P50747; Q99451" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "" "2" "0" "1.197" "1.232" "1.159" "1.060" "1.132" "1.153" "1.105" "0.791" "1.660" "19.9" "23.8" "24.5" "23.1" "21.1" "22.5" "22.9" "22.0" "15.7" "33.0" "" "" "" "" "" "" "" "" "" "" "18.0" "18.4" "19.0" "15.5" "17.6" "19.2" "19.5" "15.9" "10.6" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6054246856873050357" "False" "High" "IsMasterProtein" "Q15118" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1" "0.000" "False" "4.711" "4" "2" "2" "2" "436" "49.2" "8.81" "4.66" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "5163" "ENSG00000152256" "PDK1" "B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "T cell receptor and co-stimulatory signaling; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Hereditary leiomyomatosis and renal cell carcinoma pathway; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; GNAQ pathways in port-wine stain; EPO receptor signaling; DNA damage response (only ATM dependent)" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3555792343261501127" "False" "High" "IsMasterProtein" "P20333" "Tumor necrosis factor receptor superfamily member 1B OS=Homo sapiens OX=9606 GN=TNFRSF1B PE=1 SV=3" "0.000" "False" "4.710" "4" "1" "1" "1" "461" "48.3" "6.28" "3.04" "1" "cell-cell signaling;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf00020" "7133" "ENSG00000028137" "TNFRSF1B" "B1AJZ3; hsa:7133; P20333; Q16042; Q6YI29; Q9UIH1" "Neutrophil degranulation; Interleukin-10 signaling; TNFs bind their physiological receptors; Interleukin-4 and Interleukin-13 signaling" "TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; TYROBP causal network in microglia; Inflammatory response pathway; Neuroinflammation and glutamatergic signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2523415922773781630" "False" "High" "IsMasterProtein" "Q9Y3C1" "Nucleolar protein 16 OS=Homo sapiens OX=9606 GN=NOP16 PE=1 SV=2" "0.000" "False" "4.707" "8" "2" "2" "2" "178" "21.2" "9.94" "5.85" "2" "other biological processes" "nucleus;other cell component" "" "Pf09420" "51491" "ENSG00000048162" "NOP16" "B4DV13; D6RGD3; hsa:51491; Q05D05; Q6IAI6; Q6PIM0; Q8IXL5; Q9Y3C1" "" "5q35 copy number variation" "1" "0" "0.845" "0.764" "0.730" "0.836" "0.640" "0.800" "0.920" "0.688" "0.331" "133.2" "112.6" "101.7" "97.2" "111.4" "85.2" "106.6" "122.5" "91.6" "44.0" "" "" "" "" "" "" "" "" "" "" "120.2" "86.9" "78.7" "65.4" "92.9" "72.7" "90.4" "88.7" "61.8" "44.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5802259196988862678" "False" "High" "IsMasterProtein" "Q9NUY8" "TBC1 domain family member 23 OS=Homo sapiens OX=9606 GN=TBC1D23 PE=1 SV=3" "0.000" "False" "4.705" "3" "2" "2" "2" "699" "78.3" "5.41" "4.69" "2" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cell component" "" "Pf00566, Pf00581, Pf19430" "55773" "ENSG00000036054" "TBC1D23" "B9A6M5; hsa:55773; Q8TCN8; Q8WUB7; Q96D90; Q9NUY8; Q9NV75" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660438545085976361" "False" "High" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "0.000" "False" "4.700" "3" "1" "1" "1" "403" "43.8" "5.78" "4.37" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13831" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "0.966" "0.798" "1.051" "0.991" "0.842" "0.983" "1.029" "1.023" "1.358" "50.2" "48.5" "40.1" "52.8" "49.8" "42.3" "49.4" "51.6" "51.4" "68.2" "" "" "" "" "" "" "" "" "" "" "45.3" "37.4" "31.0" "35.5" "41.5" "36.1" "41.9" "37.4" "34.6" "68.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "151514905296234920" "False" "High" "IsMasterProtein" "Q99759" "Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2" "0.000" "False" "4.669" "3" "2" "2" "1" "626" "70.9" "8.84" "5.26" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00564" "4215" "ENSG00000198909" "MAP3K3" "B2RCW2; D3DU15; hsa:4215; Q5BKZ6; Q8N3I9; Q99759" "Interleukin-1 signaling" "IL-1 signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Pleural mesothelioma; GDNF signaling" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5616367941086101468" "False" "High" "IsMasterProtein" "Q9NRW7" "Vacuolar protein sorting-associated protein 45 OS=Homo sapiens OX=9606 GN=VPS45 PE=1 SV=1" "0.000" "False" "4.665" "3" "2" "2" "2" "570" "65.0" "8.24" "2.62" "2" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf00995" "11311" "ENSG00000136631" "VPS45" "D3DUZ9; F5H8K1; hsa:11311; Q15715; Q53FR8; Q5T4P6; Q9NRW7; Q9Y4Z6" "Factors involved in megakaryocyte development and platelet production; Intra-Golgi traffic; SARS-CoV-2 modulates autophagy" "" "3" "0" "0.896" "1.053" "1.110" "1.062" "1.079" "1.076" "0.885" "1.013" "1.657" "64.2" "57.5" "67.6" "71.2" "68.2" "69.2" "69.0" "56.8" "65.0" "106.3" "" "" "" "" "" "" "" "" "" "" "57.9" "44.4" "52.3" "48.0" "56.8" "59.1" "58.5" "41.1" "43.8" "106.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7198883007019988074" "False" "High" "IsMasterProtein" "Cont_Q8N1N4" "Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2" "0.000" "True" "4.663" "3" "2" "2" "1" "520" "56.8" "6.02" "5.97" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "196374" "ENSG00000170423" "KRT78" "A8K4D6; hsa:196374; Q5HYM7; Q7RTT2; Q8N1N4" "Formation of the cornified envelope" "" "2" "0" "1.013" "1.853" "1.335" "0.876" "0.824" "0.881" "1.408" "1.006" "0.776" "162.7" "164.8" "301.5" "217.2" "142.4" "134.0" "143.3" "229.0" "163.7" "126.2" "" "" "" "" "" "" "" "" "" "" "146.9" "127.1" "233.2" "146.3" "118.8" "114.4" "121.6" "165.7" "110.4" "126.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6678202250508335411" "False" "High" "IsMasterProtein" "Q96CS2" "HAUS augmin-like complex subunit 1 OS=Homo sapiens OX=9606 GN=HAUS1 PE=1 SV=1" "0.000" "False" "4.659" "3" "1" "1" "1" "278" "31.8" "5.53" "4.09" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "" "115106" "ENSG00000152240" "HAUS1" "B2RDM7; hsa:115106; Q8N837; Q96CS2" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "0.973" "0.926" "0.972" "0.825" "0.714" "0.884" "0.709" "0.909" "4.666" "148.7" "144.6" "137.6" "144.5" "122.6" "106.1" "131.4" "105.4" "135.2" "693.6" "" "" "" "" "" "" "" "" "" "" "134.2" "111.5" "106.4" "97.3" "102.3" "90.6" "111.4" "76.3" "91.2" "693.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2339365815424834793" "False" "High" "IsMasterProtein" "Q9Y217" "Myotubularin-related protein 6 OS=Homo sapiens OX=9606 GN=MTMR6 PE=1 SV=3" "0.000" "False" "4.658" "2" "1" "1" "1" "621" "71.9" "7.66" "3.98" "1" "protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06602, Pf21098" "9107" "ENSG00000139505" "MTMR6" "B2RBB5; B3KSB4; hsa:9107; Q5JRG6; Q86TB7; Q86YH4; Q96P80; Q9Y217" "Synthesis of PIPs at the plasma membrane" "8p23.1 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7454062146017555339" "False" "High" "IsMasterProtein" "P32019" "Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4" "0.000" "False" "4.655" "2" "2" "2" "2" "993" "112.8" "5.57" "4.78" "2" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00620, Pf16776, Pf21310" "3633" "ENSG00000204084" "INPP5B" "C9J6U5; hsa:3633; P32019; Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1" "Synthesis of IP2, IP, and Ins in the cytosol; Synthesis of IP3 and IP4 in the cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993572615210098163" "False" "High" "IsMasterProtein" "Q9UJV9" "Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2" "0.000" "False" "4.651" "2" "1" "1" "1" "622" "69.8" "6.84" "2.97" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271" "51428" "ENSG00000183258" "DDX41" "B2RDC8; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9" "mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN" "5q35 copy number variation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021225223718005983" "False" "High" "IsMasterProtein" "P31949" "Protein S100-A11 OS=Homo sapiens OX=9606 GN=S100A11 PE=1 SV=2" "0.000" "False" "4.639" "15" "2" "3" "2" "105" "11.7" "7.12" "9.07" "2" "signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6282" "ENSG00000163191" "S100A11" "hsa:6282; P31949; Q5VTK0" "Neutrophil degranulation" "" "1" "0" "1.011" "1.100" "1.120" "0.898" "1.007" "1.082" "1.018" "1.162" "0.738" "247.7" "250.5" "272.4" "277.4" "222.5" "249.5" "267.9" "252.1" "287.9" "182.9" "" "" "" "" "" "" "" "" "" "" "223.6" "193.2" "210.7" "186.8" "185.6" "213.0" "227.3" "182.4" "194.2" "182.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7261913870359179685" "False" "High" "IsMasterProtein" "O75165" "DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5" "0.000" "False" "4.629" "1" "2" "2" "2" "2243" "254.3" "6.74" "4.87" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00226, Pf14237, Pf19432" "23317" "ENSG00000138246" "DNAJC13" "hsa:23317; O75165; Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887773767884950166" "False" "High" "IsMasterProtein" "Q68DK7" "Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3" "0.000" "False" "4.628" "2" "1" "1" "1" "614" "67.1" "8.92" "3.41" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275, Pf16801" "339287" "ENSG00000188895" "MSL1" "hsa:339287; Q0VF46; Q68DK7; Q69Z03" "HATs acetylate histones" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6680775627371570044" "False" "High" "IsMasterProtein" "Q9Y6V0" "Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5" "0.000" "False" "4.626" "0" "2" "11" "2" "5142" "560.4" "6.47" "31.37" "2" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00168, Pf00595, Pf05715" "27445" "ENSG00000186472" "PCLO" "A4D1A7; A6NNX9; O43373; O60305; Q08E72; Q9BVC8; Q9UIV2; Q9Y6U9; Q9Y6V0" "Sensory processing of sound by inner hair cells of the cochlea" "Cell lineage map for neuronal differentiation" "2" "0" "0.943" "1.024" "0.960" "0.978" "0.928" "1.005" "1.067" "1.049" "0.699" "740.7" "698.6" "758.5" "711.2" "724.3" "687.2" "744.5" "790.4" "777.4" "517.9" "" "" "" "" "" "" "" "" "" "" "668.6" "538.8" "586.6" "478.9" "604.2" "586.6" "631.6" "572.0" "524.3" "517.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8336959389003651340" "False" "High" "IsMasterProtein" "Q9NZJ4" "Sacsin OS=Homo sapiens OX=9606 GN=SACS PE=1 SV=2" "0.000" "False" "4.607" "0" "1" "1" "1" "4579" "520.8" "7.05" "3.68" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00240, Pf05168" "26278" "ENSG00000151835" "SACS" "hsa:26278; O94835; Q5T9J5; Q5T9J7; Q5T9J8; Q68DF5; Q6MZR4; Q8NBF9; Q9NZJ4" "" "13q12.12 copy number variation" "1" "0" "1.041" "1.137" "1.274" "1.488" "1.056" "1.314" "1.081" "1.382" "1.852" "103.1" "107.3" "117.2" "131.4" "153.5" "108.9" "135.5" "111.5" "142.5" "191.0" "" "" "" "" "" "" "" "" "" "" "93.1" "82.8" "90.7" "88.5" "128.0" "92.9" "115.0" "80.7" "96.1" "191.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256308892199755457" "False" "High" "IsMasterProtein" "Q969J3" "BLOC-1-related complex subunit 5 OS=Homo sapiens OX=9606 GN=BORCS5 PE=1 SV=1" "0.000" "False" "4.605" "9" "2" "2" "2" "196" "22.2" "6.35" "5.67" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf10158" "118426" "ENSG00000165714; ENSG00000280689" "BORCS5" "hsa:118426; Q969J3; Q96QS5" "" "" "0" "0" "0.830" "0.917" "0.899" "0.874" "0.989" "0.968" "0.866" "0.898" "0.759" "125.4" "104.1" "115.0" "112.8" "109.6" "124.1" "121.3" "108.6" "112.6" "95.1" "" "" "" "" "" "" "" "" "" "" "113.2" "80.3" "89.0" "75.9" "91.4" "105.9" "102.9" "78.6" "75.9" "95.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "364086976847350379" "False" "High" "IsMasterProtein" "Q7L592" "Protein arginine methyltransferase NDUFAF7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF7 PE=1 SV=1" "0.000" "False" "4.602" "2" "1" "1" "1" "441" "49.2" "8.34" "2.79" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf02636" "55471" "ENSG00000003509" "NDUFAF7" "hsa:55471; Q7L592; Q7Z399; Q9P1G3" "Complex I biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1311899877800093537" "False" "High" "IsMasterProtein" "Q9H0K6" "Pseudouridylate synthase PUS7L OS=Homo sapiens OX=9606 GN=PUS7L PE=1 SV=1" "0.000" "False" "4.599" "1" "1" "1" "1" "701" "80.6" "7.56" "3.43" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01142" "83448" "ENSG00000129317" "PUS7L" "B3KUJ1; hsa:83448; Q05CU0; Q6AHZ3; Q6NUP2; Q9H0K6" "" "" "0" "0" "1.041" "0.999" "1.342" "1.044" "1.094" "1.234" "1.129" "1.113" "1.458" "63.6" "66.3" "63.6" "85.4" "66.5" "69.6" "78.5" "71.9" "70.8" "92.8" "" "" "" "" "" "" "" "" "" "" "57.4" "51.1" "49.2" "57.5" "55.4" "59.4" "66.6" "52.0" "47.8" "92.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4531671785395663771" "False" "High" "IsMasterProtein" "Q5SXM8" "DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1" "0.000" "False" "4.598" "5" "1" "1" "1" "178" "19.2" "9.80" "3.28" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf05180" "728489" "ENSG00000213221" "DNLZ" "B2RUX5; B9EJE1; hsa:728489; Q5SXM8" "" "" "0" "0" "1.361" "1.153" "1.192" "1.079" "1.103" "1.194" "1.181" "1.147" "0.866" "61.4" "83.5" "70.7" "73.1" "66.2" "67.7" "73.2" "72.5" "70.4" "53.1" "" "" "" "" "" "" "" "" "" "" "55.4" "64.4" "54.7" "49.3" "55.2" "57.8" "62.1" "52.5" "47.5" "53.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5295951375825513477" "False" "High" "IsMasterProtein" "Q14186" "Transcription factor Dp-1 OS=Homo sapiens OX=9606 GN=TFDP1 PE=1 SV=1" "0.000" "False" "4.597" "5" "1" "1" "1" "410" "45.0" "6.05" "3.34" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf08781" "7027" "ENSG00000198176" "TFDP1" "B4DLQ9; hsa:7027; Q14186; Q5JSB4; Q8IZL5" "Oxidative Stress Induced Senescence; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional Regulation by E2F6; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; Transcriptional regulation of granulopoiesis; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Activation of NOXA and translocation to mitochondria; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; G1 to S cell cycle control; DYRK1A involvement regarding cell proliferation in brain development" "23" "0" "1.336" "0.948" "1.020" "1.046" "1.090" "1.323" "0.807" "1.116" "1.793" "12.2" "16.3" "11.5" "12.4" "12.7" "13.3" "16.1" "9.8" "13.6" "21.8" "" "" "" "" "" "" "" "" "" "" "11.0" "12.5" "8.9" "8.4" "10.6" "11.3" "13.7" "7.1" "9.2" "21.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850236467978773586" "False" "High" "IsMasterProtein" "P40692" "DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1" "0.000" "False" "4.593" "3" "2" "2" "2" "756" "84.5" "5.72" "4.61" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf13589, Pf16413" "4292" "ENSG00000076242" "MLH1" "B4DI13; B4DQ11; E9PCU2; hsa:4292; P40692" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "Ovarian infertility; Chromosomal and microsatellite instability in colorectal cancer ; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "12" "0" "1.075" "0.889" "1.000" "0.962" "1.084" "0.987" "0.893" "1.072" "2.932" "73.1" "78.5" "64.9" "73.1" "70.3" "79.2" "72.1" "65.2" "78.3" "214.3" "" "" "" "" "" "" "" "" "" "" "66.0" "60.6" "50.2" "49.2" "58.6" "67.6" "61.2" "47.2" "52.8" "214.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2992293195289622245" "False" "High" "IsMasterProtein" "Q15005" "Signal peptidase complex subunit 2 OS=Homo sapiens OX=9606 GN=SPCS2 PE=1 SV=3" "0.000" "False" "4.591" "10" "1" "1" "1" "226" "25.0" "8.47" "3.19" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "" "Pf06703" "9789" "ENSG00000118363" "SPCS2" "hsa:9789; Q15005; Q15507; Q3KQT0; Q641R4; Q6FG65; Q6IRX0; Q6P1P4; Q96HU9" "SRP-dependent cotranslational protein targeting to membrane; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP); Maturation of hRSV A proteins; Synthesis, secretion, and deacylation of Ghrelin" "15q25 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "High" "Not Found" "Not Found" "High" "High" "Not Found" "High" "1" "" "-8764284085983728716" "False" "High" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0.000" "False" "4.583" "0" "1" "1" "1" "2426" "263.7" "5.64" "3.77" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "0.973" "0.838" "1.162" "0.959" "1.064" "0.865" "0.907" "0.935" "2.740" "73.8" "71.9" "61.9" "85.8" "70.8" "78.6" "63.8" "67.0" "69.0" "202.3" "" "" "" "" "" "" "" "" "" "" "66.7" "55.4" "47.8" "57.8" "59.1" "67.1" "54.2" "48.5" "46.6" "202.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-101820050033511890" "False" "High" "IsMasterProtein" "Q14966" "Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2" "0.000" "False" "4.579" "1" "1" "1" "1" "1978" "220.5" "6.38" "2.91" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12171" "27332" "ENSG00000075292" "ZNF638" "A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37" "Transcriptional regulation of white adipocyte differentiation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6429762109324514714" "False" "High" "IsMasterProtein" "O75607" "Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3" "0.000" "False" "4.576" "6" "1" "2" "1" "178" "19.3" "4.63" "6.17" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03066" "10360" "ENSG00000107833" "NPM3" "hsa:10360; O75607; Q9UNY6" "" "" "0" "0" "0.980" "0.922" "1.054" "1.002" "0.827" "0.942" "0.971" "1.043" "0.830" "134.4" "131.7" "123.9" "141.6" "134.7" "111.2" "126.6" "130.5" "140.3" "111.6" "" "" "" "" "" "" "" "" "" "" "121.3" "101.6" "95.8" "95.4" "112.4" "94.9" "107.4" "94.4" "94.6" "111.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4278249940828633973" "False" "High" "IsMasterProtein" "P32321" "Deoxycytidylate deaminase OS=Homo sapiens OX=9606 GN=DCTD PE=1 SV=2" "0.000" "False" "4.569" "6" "1" "3" "1" "178" "20.0" "7.56" "6.65" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00383" "1635" "ENSG00000129187" "DCTD" "B2R836; D3DP49; D3DP50; hsa:1635; P32321; Q5M7Z8; Q9BVD8" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3119089922168410835" "False" "High" "IsMasterProtein" "P10606" "Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2" "0.000" "False" "4.564" "15" "2" "2" "2" "129" "13.7" "8.81" "5.31" "2" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01215" "1329" "ENSG00000135940; ENSG00000291596" "COX5B" "hsa:1329; P10606; Q53YB7; Q96J18; Q99610" "Mitochondrial protein degradation; Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1503815789163397173" "False" "High" "IsMasterProtein" "Q9NRG7" "Epimerase family protein SDR39U1 OS=Homo sapiens OX=9606 GN=SDR39U1 PE=1 SV=3" "0.000" "False" "4.560" "3" "1" "1" "1" "293" "31.1" "9.04" "2.70" "1" "" "" "other molecular function" "Pf01370, Pf08338" "56948" "ENSG00000100445" "SDR39U1" "hsa:56948; Q6ZW71; Q9BVQ3; Q9NRG7" "" "" "0" "0" "1.043" "0.916" "1.322" "1.123" "1.214" "0.961" "1.174" "1.033" "1.312" "37.4" "39.0" "34.3" "49.4" "42.0" "45.4" "35.9" "43.9" "38.6" "49.1" "" "" "" "" "" "" "" "" "" "" "33.8" "30.1" "26.5" "33.3" "35.0" "38.7" "30.5" "31.8" "26.1" "49.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4342326397945372791" "False" "High" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "0.000" "False" "4.560" "3" "3" "3" "2" "1001" "113.6" "6.29" "4.78" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "E3 ubiquitin ligases ubiquitinate target proteins" "ATM signaling in development and disease" "2" "1" "1.168" "1.225" "1.304" "1.051" "1.092" "1.047" "0.664" "1.362" "12.172" "58.6" "68.5" "71.8" "76.4" "61.6" "64.0" "61.4" "38.9" "79.8" "713.6" "" "" "" "" "" "" "" "" "" "" "52.9" "52.8" "55.5" "51.5" "51.4" "54.6" "52.1" "28.2" "53.8" "713.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2136811018986940550" "False" "High" "IsMasterProtein" "Q9NS91" "E3 ubiquitin-protein ligase RAD18 OS=Homo sapiens OX=9606 GN=RAD18 PE=1 SV=2" "0.000" "False" "4.556" "2" "1" "1" "1" "495" "56.2" "7.58" "3.41" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf13923" "56852" "ENSG00000070950" "RAD18" "Q58F55; Q9NRT6; Q9NS91" "Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins" "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "3" "0" "1.085" "1.022" "1.460" "1.118" "0.972" "1.177" "1.154" "1.130" "4.247" "58.8" "63.8" "60.1" "85.9" "65.7" "57.1" "69.2" "67.9" "66.5" "249.8" "" "" "" "" "" "" "" "" "" "" "53.1" "49.2" "46.5" "57.8" "54.8" "48.8" "58.7" "49.1" "44.8" "249.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7530688595643988973" "False" "High" "IsMasterProtein" "Q13510" "Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5" "0.000" "False" "4.550" "5" "2" "2" "2" "395" "44.6" "7.62" "4.86" "2" "other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "427" "ENSG00000104763" "ASAH1" "E9PDS0; hsa:427; Q13510; Q6W898; Q96AS2" "Neutrophil degranulation; Glycosphingolipid catabolism" "Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Synthesis of ceramides and 1-deoxyceramides" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6232139059952850141" "False" "High" "IsMasterProtein" "O94874" "E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2" "0.000" "False" "4.546" "1" "1" "1" "1" "794" "89.5" "6.79" "3.23" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09743" "23376" "ENSG00000014123" "UFL1" "A0PJ53; B4DJ57; C0H5X5; hsa:23376; O94874; Q8N765; Q9NTQ0" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.824" "0.878" "1.068" "1.077" "0.823" "0.973" "1.081" "1.023" "2.808" "87.2" "71.9" "76.6" "93.1" "93.9" "71.8" "84.9" "94.3" "89.2" "244.9" "" "" "" "" "" "" "" "" "" "" "78.7" "55.4" "59.3" "62.7" "78.3" "61.3" "72.0" "68.2" "60.2" "244.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-60388765585118576" "False" "High" "IsMasterProtein" "Q9H875" "PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1" "0.000" "False" "4.540" "5" "1" "2" "1" "184" "21.0" "9.79" "7.12" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06658" "79706" "ENSG00000128563" "PRKRIP1" "B4DGM2; hsa:79706; Q8NDM6; Q96CF8; Q9H875" "mRNA Splicing - Major Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9059271771169400119" "False" "High" "IsMasterProtein" "Q9UBK9" "Protein UXT OS=Homo sapiens OX=9606 GN=UXT PE=1 SV=1" "0.000" "False" "4.535" "11" "2" "2" "2" "157" "18.2" "7.59" "5.60" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "8409" "ENSG00000126756" "UXT" "A0A0C4DFR8; B2R561; hsa:8409; Q5JZG3; Q9UBK9; Q9Y6E5" "Transcriptional Regulation by E2F6" "" "1" "0" "1.094" "1.065" "1.172" "1.088" "1.283" "1.222" "1.081" "1.387" "1.805" "88.1" "96.4" "93.8" "103.3" "95.8" "113.0" "107.6" "95.3" "122.2" "159.0" "" "" "" "" "" "" "" "" "" "" "79.5" "74.4" "72.6" "69.5" "79.9" "96.4" "91.3" "69.0" "82.4" "159.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7161908197236874210" "False" "High" "IsMasterProtein" "Q9BTV5" "Fibronectin type III and SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FSD1 PE=1 SV=1" "0.000" "False" "4.532" "6" "3" "3" "3" "496" "55.8" "6.99" "6.59" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00041, Pf00622" "79187" "ENSG00000105255" "FSD1" "B2RDT0; hsa:79187; Q9BTV5; Q9BXN0; Q9HAG4" "" "" "0" "0" "1.070" "0.773" "1.047" "1.022" "0.831" "0.964" "1.026" "0.821" "0.850" "221.2" "236.5" "170.9" "231.5" "226.1" "183.9" "213.2" "226.9" "181.6" "188.1" "" "" "" "" "" "" "" "" "" "" "199.6" "182.5" "132.2" "155.9" "188.6" "157.0" "180.9" "164.2" "122.5" "188.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2918128559095144433" "False" "High" "IsMasterProtein" "Q9NRA8" "Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2" "0.000" "False" "4.526" "2" "2" "2" "2" "985" "108.1" "8.32" "6.06" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10477" "56478" "ENSG00000184708" "EIF4ENIF1" "B1AKL2; B1AKL3; B2RBF1; hsa:56478; Q8NCF2; Q9H708; Q9NRA8" "" "Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "2" "0" "0.883" "1.211" "0.887" "1.098" "1.264" "0.972" "1.063" "1.284" "1.583" "89.5" "79.0" "108.4" "79.4" "98.2" "113.2" "87.0" "95.2" "114.9" "141.6" "" "" "" "" "" "" "" "" "" "" "80.8" "61.0" "83.8" "53.5" "81.9" "96.6" "73.8" "68.9" "77.5" "141.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4021135707239228724" "False" "High" "IsMasterProtein" "Q92664" "Transcription factor IIIA OS=Homo sapiens OX=9606 GN=GTF3A PE=1 SV=3" "0.000" "False" "4.510" "2" "1" "1" "1" "365" "41.5" "9.14" "3.88" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "2971" "ENSG00000122034" "GTF3A" "B7ZBK5; hsa:2971; Q12963; Q13097; Q92664" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter" "Adipogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1812209145391096347" "False" "High" "IsMasterProtein" "P07919" "Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2" "0.000" "False" "4.503" "37" "2" "2" "2" "91" "10.7" "4.44" "3.85" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02320" "7388" "ENSG00000173660" "UQCRH" "B2R4V9; D3DQ18; hsa:7388; P07919; Q5TDF6; Q6LDB8; Q9BQ91" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "1.113" "1.028" "0.911" "0.966" "1.007" "1.012" "1.128" "0.941" "0.478" "323.1" "359.6" "332.2" "294.2" "312.1" "325.4" "327.0" "364.3" "303.9" "154.4" "" "" "" "" "" "" "" "" "" "" "291.6" "277.3" "256.9" "198.1" "260.4" "277.7" "277.4" "263.7" "205.0" "154.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653073458972591476" "False" "High" "IsMasterProtein" "O75683" "Surfeit locus protein 6 OS=Homo sapiens OX=9606 GN=SURF6 PE=1 SV=3" "0.000" "False" "4.495" "6" "2" "2" "2" "361" "41.4" "10.64" "3.96" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04935" "6838" "ENSG00000148296; ENSG00000281309" "SURF6" "hsa:6838; O75683; Q5T8U1; Q9BRK9; Q9BTZ5; Q9UK24" "" "" "0" "0" "1.073" "0.813" "0.900" "0.957" "1.111" "1.000" "1.296" "1.649" "0.852" "12.3" "13.2" "10.0" "11.1" "11.8" "13.7" "12.3" "16.0" "20.3" "10.5" "" "" "" "" "" "" "" "" "" "" "11.1" "10.2" "7.7" "7.5" "9.8" "11.7" "10.5" "11.6" "13.7" "10.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072940265532369101" "False" "High" "IsMasterProtein" "Q9NY26" "Zinc transporter ZIP1 OS=Homo sapiens OX=9606 GN=SLC39A1 PE=1 SV=1" "0.000" "False" "4.493" "4" "1" "1" "1" "324" "34.2" "5.92" "3.88" "1" "transport;developmental processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;transporter activity" "Pf02535" "27173" "ENSG00000143570" "SLC39A1" "B4DDY7; hsa:27173; Q5T4K1; Q8N2H7; Q9BTV0; Q9NY26; Q9UBI7; Q9Y2Z7; Q9Y380" "Zinc influx into cells by the SLC39 gene family" "Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis" "4" "0" "1.131" "1.022" "0.782" "1.165" "0.858" "1.145" "1.240" "1.038" "0.743" "38.6" "43.6" "39.4" "30.1" "44.9" "33.1" "44.2" "47.8" "40.0" "28.6" "" "" "" "" "" "" "" "" "" "" "34.8" "33.6" "30.5" "20.3" "37.5" "28.2" "37.5" "34.6" "27.0" "28.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6149624510723031081" "False" "High" "IsMasterProtein" "P30043" "Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3" "0.000" "False" "4.487" "10" "2" "3" "2" "206" "22.1" "7.65" "7.75" "2" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13460" "645" "ENSG00000090013" "BLVRB" "A6NKD8; B2R5C6; hsa:645; P30043; P32078; P53005; Q32LZ2" "Cytoprotection by HMOX1; Heme degradation" "Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway" "5" "0" "1.103" "0.724" "0.939" "0.902" "0.707" "0.930" "0.949" "0.852" "0.884" "99.8" "110.1" "72.2" "93.7" "90.0" "70.5" "92.8" "94.7" "85.0" "88.2" "" "" "" "" "" "" "" "" "" "" "90.1" "84.9" "55.9" "63.1" "75.0" "60.2" "78.8" "68.6" "57.4" "88.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758038755542979545" "False" "High" "IsMasterProtein" "P61769" "Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1" "0.000" "False" "4.485" "8" "1" "1" "1" "119" "13.7" "6.52" "3.83" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07654" "567" "ENSG00000166710; ENSG00000273686" "B2M" "hsa:567; P01884; P61769; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4" "ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Amyloid fiber formation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; DAP12 signaling; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "IL-18 signaling pathway" "13" "0" "1.014" "1.046" "0.328" "0.187" "0.906" "0.549" "1.124" "0.568" "0.615" "158.9" "161.1" "166.2" "52.1" "29.7" "144.0" "87.3" "178.6" "90.3" "97.7" "" "" "" "" "" "" "" "" "" "" "143.4" "124.3" "128.5" "35.1" "24.8" "122.9" "74.0" "129.2" "60.9" "97.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157020147431294409" "False" "High" "IsMasterProtein" "P17028" "Zinc finger protein 24 OS=Homo sapiens OX=9606 GN=ZNF24 PE=1 SV=4" "0.000" "False" "4.484" "3" "1" "1" "1" "368" "42.1" "6.21" "2.93" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7572" "ENSG00000172466" "ZNF24" "hsa:7572; O14754; P17028; Q53YE4; Q6ICR5; Q8IZN4" "" "" "0" "0" "1.057" "1.230" "1.241" "0.931" "1.311" "0.810" "1.045" "1.365" "1.358" "47.4" "50.1" "58.4" "58.9" "44.2" "62.2" "38.4" "49.6" "64.8" "64.4" "" "" "" "" "" "" "" "" "" "" "42.8" "38.7" "45.1" "39.6" "36.8" "53.1" "32.6" "35.9" "43.7" "64.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "689463057038776482" "False" "High" "IsMasterProtein" "Q6ZS17" "Rho family-interacting cell polarization regulator 1 OS=Homo sapiens OX=9606 GN=RIPOR1 PE=1 SV=1" "0.000" "False" "4.484" "1" "1" "1" "1" "1223" "132.2" "6.28" "3.05" "1" "stress response;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf15903" "79567" "ENSG00000039523" "RIPOR1" "B4DEQ9; B4DIM2; E9PBS3; hsa:79567; Q4G0A4; Q6ZS17; Q7Z5R7; Q8NDA4; Q96J39; Q96PV8; Q9H8D9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-139215625365560454" "False" "High" "IsMasterProtein" "O00566" "U3 small nucleolar ribonucleoprotein protein MPP10 OS=Homo sapiens OX=9606 GN=MPHOSPH10 PE=1 SV=2" "0.000" "False" "4.478" "1" "1" "1" "1" "681" "78.8" "4.86" "3.60" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf04006" "10199" "ENSG00000124383" "MPHOSPH10" "A0AVJ8; hsa:10199; O00566" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3251475669442544967" "False" "High" "IsMasterProtein" "Q9P270" "SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2" "0.000" "False" "4.477" "3" "2" "2" "2" "581" "62.5" "9.45" "6.07" "2" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15301" "57606" "ENSG00000109171" "SLAIN2" "A8K4P1; hsa:57606; Q8N5R3; Q9P270" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472695818303021401" "False" "High" "IsMasterProtein" "P22087" "rRNA 2'-O-methyltransferase fibrillarin OS=Homo sapiens OX=9606 GN=FBL PE=1 SV=2" "0.000" "False" "4.476" "4" "2" "2" "2" "321" "33.8" "10.18" "5.82" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01269" "2091" "ENSG00000105202; ENSG00000280548" "FBL" "B5BUE8; hsa:2091; O75259; P22087; Q6IAT5; Q9UPI6" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "Rubinstein-Taybi syndrome 1" "3" "0" "1.223" "0.777" "0.972" "1.178" "0.835" "1.122" "1.042" "0.797" "1.005" "94.6" "115.7" "73.5" "91.9" "111.5" "79.0" "106.2" "98.6" "75.4" "95.1" "" "" "" "" "" "" "" "" "" "" "85.4" "89.2" "56.9" "61.9" "93.0" "67.5" "90.1" "71.4" "50.8" "95.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375562830836446683" "False" "High" "IsMasterProtein" "Q15386" "Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3" "0.000" "False" "4.472" "1" "2" "2" "2" "1083" "123.8" "6.71" "4.63" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632" "9690" "ENSG00000009335" "UBE3C" "A4D235; A6NCP3; hsa:9690; Q15386; Q8TC15; Q96CR4; Q9UDU3" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.974" "1.034" "1.113" "1.089" "0.976" "1.076" "1.112" "0.950" "1.514" "137.0" "133.4" "141.7" "152.4" "149.1" "133.8" "147.4" "152.3" "130.2" "207.4" "" "" "" "" "" "" "" "" "" "" "123.7" "102.9" "109.6" "102.6" "124.4" "114.2" "125.0" "110.2" "87.8" "207.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6202573485252222351" "False" "High" "IsMasterProtein" "Q9NZD2" "Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3" "0.000" "False" "4.455" "4" "1" "1" "1" "209" "23.8" "7.39" "3.69" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol" "transporter activity;other molecular function" "Pf08718" "51228" "ENSG00000139433" "GLTP" "hsa:51228; Q53Z13; Q96J68; Q9NZD2" "Glycosphingolipid transport" "" "1" "0" "0.941" "1.106" "0.921" "0.986" "0.961" "0.917" "0.944" "0.997" "0.826" "153.5" "144.4" "169.8" "141.3" "151.4" "147.5" "140.7" "144.9" "153.0" "126.7" "" "" "" "" "" "" "" "" "" "" "138.6" "111.4" "131.4" "95.2" "126.3" "125.9" "119.4" "104.9" "103.2" "126.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4201760533929060036" "False" "High" "IsMasterProtein" "P63313" "Thymosin beta-10 OS=Homo sapiens OX=9606 GN=TMSB10 PE=1 SV=2" "0.000" "False" "4.454" "18" "2" "9" "2" "44" "5.0" "5.36" "20.67" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf01290" "9168" "ENSG00000034510" "TMSB10" "hsa:9168; P13472; P63313; Q596K9" "" "VEGFA-VEGFR2 signaling; Extrafollicular and follicular B cell activation by SARS-CoV-2" "2" "0" "1.046" "1.027" "1.048" "1.007" "0.841" "1.079" "1.190" "1.091" "0.637" "640.6" "669.9" "658.1" "671.5" "645.3" "538.7" "691.0" "762.3" "698.9" "408.2" "" "" "" "" "" "" "" "" "" "" "578.3" "516.7" "509.0" "452.2" "538.3" "459.8" "586.1" "551.7" "471.4" "408.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8347343991909543181" "False" "High" "IsMasterProtein" "P48200" "Iron-responsive element-binding protein 2 OS=Homo sapiens OX=9606 GN=IREB2 PE=1 SV=4" "0.000" "False" "4.450" "1" "1" "1" "1" "963" "105.0" "7.05" "3.60" "1" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "3658" "ENSG00000136381" "IREB2" "A0A0A6YY96; A8KAC7; E1CJT9; H0YKU0; hsa:3658; P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17" "Iron uptake and transport" "Iron metabolism in placenta; Ferroptosis" "3" "0" "0.914" "1.208" "0.905" "0.648" "1.170" "1.124" "0.761" "1.176" "3.714" "53.3" "48.7" "64.4" "48.3" "34.6" "62.4" "60.0" "40.6" "62.7" "198.1" "" "" "" "" "" "" "" "" "" "" "48.1" "37.6" "49.8" "32.5" "28.8" "53.2" "50.9" "29.4" "42.3" "198.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3953719107085229180" "False" "High" "IsMasterProtein" "Q9Y6K9" "NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2" "0.000" "False" "4.432" "5" "2" "2" "2" "419" "48.2" "5.71" "3.58" "2" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf11577, Pf16516, Pf18414" "8517" "ENSG00000269335" "IKBKG" "hsa:8517; Q7LBY6; Q7Z7F1; Q9Y6K9" "PKR-mediated signaling; Downstream TCR signaling; ER-Phagosome pathway; SARS-CoV-2 activates/modulates innate and adaptive immune responses; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; Ub-specific processing proteases; TAK1-dependent IKK and NF-kappa-B activation ; FCERI mediated NF-kB activation; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Ovarian tumor domain proteases; SUMOylation of immune response proteins" "Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "76" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8034699390765478794" "False" "High" "IsMasterProtein" "Q9UID3" "Vacuolar protein sorting-associated protein 51 homolog OS=Homo sapiens OX=9606 GN=VPS51 PE=1 SV=2" "0.000" "False" "4.413" "2" "1" "1" "1" "782" "86.0" "6.47" "2.75" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08700" "738" "ENSG00000149823" "VPS51" "hsa:738; Q6PJV5; Q7L8A6; Q8WZ35; Q96DF4; Q96GR3; Q9UID3" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.853" "1.105" "1.209" "1.163" "0.903" "1.134" "1.086" "1.032" "1.903" "29.5" "25.2" "32.6" "35.7" "34.4" "26.7" "33.5" "32.1" "30.5" "56.2" "" "" "" "" "" "" "" "" "" "" "26.7" "19.4" "25.2" "24.0" "28.7" "22.8" "28.4" "23.2" "20.6" "56.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9164959202025983104" "False" "High" "IsMasterProtein" "Q9BSJ2" "Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2" "0.000" "False" "4.413" "2" "2" "3" "2" "902" "102.5" "6.84" "5.56" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf04130, Pf17681" "10844" "ENSG00000130640" "TUBGCP2" "B4DM18; B7ZKL8; F5H4E0; F5H4L0; hsa:10844; O43632; Q5VWX7; Q9BSJ2" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900413936480429684" "False" "High" "IsMasterProtein" "Q9Y6I4" "Ubiquitin carboxyl-terminal hydrolase 3 OS=Homo sapiens OX=9606 GN=USP3 PE=1 SV=2" "0.000" "False" "4.413" "3" "2" "2" "2" "520" "58.9" "8.18" "5.80" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00443, Pf02148" "9960" "ENSG00000140455" "USP3" "B4DVU5; F5H1A6; hsa:9960; Q8WVD0; Q9Y6I4" "Ub-specific processing proteases" "" "1" "0" "1.192" "1.087" "1.143" "0.931" "0.948" "1.061" "0.917" "0.880" "2.193" "55.2" "65.8" "60.0" "63.1" "51.4" "52.3" "58.6" "50.6" "48.6" "121.1" "" "" "" "" "" "" "" "" "" "" "49.8" "50.8" "46.4" "42.5" "42.9" "44.7" "49.7" "36.6" "32.8" "121.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8524788288681439212" "False" "High" "IsMasterProtein" "O15164" "Transcription intermediary factor 1-alpha OS=Homo sapiens OX=9606 GN=TRIM24 PE=1 SV=3" "0.000" "False" "4.412" "1" "1" "1" "1" "1050" "116.8" "7.11" "2.90" "1" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf00628, Pf00643" "8805" "ENSG00000122779" "TRIM24" "A4D1R7; A4D1R8; hsa:8805; O15164; O95854" "Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "" "3" "0" "1.049" "2.765" "1.269" "0.956" "2.341" "0.845" "0.832" "2.521" "2.882" "35.4" "37.2" "98.0" "45.0" "33.9" "83.0" "29.9" "29.5" "89.4" "102.2" "" "" "" "" "" "" "" "" "" "" "32.0" "28.7" "75.8" "30.3" "28.3" "70.8" "25.4" "21.3" "60.3" "102.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4119933875415276465" "False" "High" "IsMasterProtein" "P07902" "Galactose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=GALT PE=1 SV=3" "0.000" "False" "4.409" "3" "1" "1" "1" "379" "43.3" "6.99" "3.87" "1" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01087, Pf02744" "2592" "ENSG00000213930" "GALT" "B4E097; E7ET32; hsa:2592; P07902; Q14355; Q14356; Q14357; Q14358; Q14359; Q14360; Q14361; Q14363; Q14364; Q14365; Q14369; Q14370; Q14371; Q14372; Q14373; Q14374; Q14375; Q14377; Q14378; Q14380; Q14381; Q14382; Q14383; Q14384; Q14385; Q14386; Q14387; Q14389; Q16766; Q53XK1; Q5VZ81; Q96BY1" "Defective GALT can cause GALCT; Galactose catabolism" "Disorders of galactose metabolism ; Primary ovarian insufficiency" "4" "0" "1.046" "0.997" "1.061" "1.107" "1.183" "1.105" "1.060" "1.078" "0.851" "82.2" "86.0" "82.0" "87.2" "91.1" "97.3" "90.9" "87.1" "88.6" "70.0" "" "" "" "" "" "" "" "" "" "" "74.2" "66.4" "63.5" "58.7" "76.0" "83.0" "77.1" "63.1" "59.8" "70.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2106052778808331693" "False" "High" "IsMasterProtein" "P62910" "Large ribosomal subunit protein eL32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2" "0.000" "False" "4.408" "11" "2" "2" "2" "135" "15.9" "11.33" "5.76" "2" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01655" "6161" "ENSG00000144713" "RPL32" "B2R4Q3; hsa:6161; P02433; P62910" "Major pathway of rRNA processing in the nucleolus and cytosol; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.824" "1.118" "0.887" "0.909" "1.105" "1.109" "0.984" "1.148" "0.380" "143.1" "117.9" "159.9" "127.0" "130.1" "158.1" "158.7" "140.8" "164.3" "54.4" "" "" "" "" "" "" "" "" "" "" "129.2" "91.0" "123.7" "85.5" "108.5" "134.9" "134.6" "101.9" "110.8" "54.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4134532342981628088" "False" "High" "IsMasterProtein" "Q9BSV6" "tRNA-splicing endonuclease subunit Sen34 OS=Homo sapiens OX=9606 GN=TSEN34 PE=1 SV=1" "0.000" "False" "4.399" "4" "1" "1" "1" "310" "33.6" "8.43" "2.97" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01974" "79042" "ENSG00000170892; ENSG00000273896; ENSG00000274078; ENSG00000274129; ENSG00000274672; ENSG00000274796; ENSG00000275165; ENSG00000278605; ENSG00000278622; ENSG00000278712" "TSEN34" "A6NNB1; B0V3J1; hsa:79042; Q9BSV6; Q9BVT1; Q9H6H5" "tRNA processing in the nucleus" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5064589920710455811" "False" "High" "IsMasterProtein" "O00635" "E3 ubiquitin-protein ligase TRIM38 OS=Homo sapiens OX=9606 GN=TRIM38 PE=1 SV=1" "0.000" "False" "4.398" "4" "2" "2" "2" "465" "53.4" "7.02" "4.84" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "10475" "ENSG00000112343" "TRIM38" "B2R862; hsa:10475; O00635" "Interferon gamma signaling" "" "1" "0" "1.103" "0.951" "1.028" "1.126" "0.979" "1.052" "0.692" "1.014" "7.507" "53.1" "58.5" "50.5" "54.5" "59.7" "52.0" "55.8" "36.7" "53.8" "398.3" "" "" "" "" "" "" "" "" "" "" "47.9" "45.1" "39.0" "36.7" "49.8" "44.4" "47.4" "26.6" "36.3" "398.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3522483334195236405" "False" "High" "IsMasterProtein" "Q13542" "Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1" "0.000" "False" "4.398" "11" "1" "1" "1" "120" "12.9" "6.67" "3.10" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05456" "1979" "ENSG00000148730" "EIF4EBP2" "hsa:1979; Q13542" "" "Translation factors; Fragile X syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8612473288009054962" "False" "High" "IsMasterProtein" "Q16626" "Male-enhanced antigen 1 OS=Homo sapiens OX=9606 GN=MEA1 PE=1 SV=2" "0.000" "False" "4.396" "7" "1" "1" "1" "185" "19.9" "4.22" "2.99" "1" "developmental processes;other biological processes" "other cell component" "" "Pf06910" "4201" "ENSG00000124733" "MEA1" "hsa:4201; Q16626; Q5TC36; Q9BV01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1078046361948541096" "False" "High" "IsMasterProtein" "Q6UWP2" "Dehydrogenase/reductase SDR family member 11 OS=Homo sapiens OX=9606 GN=DHRS11 PE=1 SV=1" "0.000" "False" "4.394" "4" "1" "1" "1" "260" "28.3" "6.64" "3.24" "1" "other metabolic processes" "non-structural extracellular" "other molecular function" "Pf00106" "79154" "ENSG00000275397; ENSG00000278535" "DHRS11" "A0A0U5BLD0; B2RDZ3; hsa:79154; Q6UWP2; Q9BUC7; Q9H674" "" "17q12 copy number variation syndrome" "1" "0" "1.020" "0.735" "0.913" "0.939" "0.841" "0.998" "1.015" "0.895" "0.649" "69.9" "71.3" "51.4" "63.8" "65.6" "58.8" "69.8" "70.9" "62.5" "45.3" "" "" "" "" "" "" "" "" "" "" "63.1" "55.0" "39.7" "43.0" "54.7" "50.2" "59.2" "51.3" "42.2" "45.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5511043592146931857" "False" "High" "IsMasterProtein" "Q9BSB4" "Autophagy-related protein 101 OS=Homo sapiens OX=9606 GN=ATG101 PE=1 SV=1" "0.000" "False" "4.393" "5" "1" "1" "1" "218" "25.0" "6.15" "3.79" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf07855" "60673" "ENSG00000123395" "ATG101" "hsa:60673; Q9BSB4; Q9HAE2; Q9HBN1" "Macroautophagy" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "652466818170242457" "False" "High" "IsMasterProtein" "Q9H993" "Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1" "0.000" "False" "4.391" "2" "1" "1" "1" "441" "51.1" "5.76" "3.52" "1" "other metabolic processes;stress response" "" "other molecular function" "Pf01937" "79624" "ENSG00000146476" "ARMT1" "hsa:79624; Q96FC6; Q9H993; Q9UFY5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1010351863231639578" "False" "High" "IsMasterProtein" "Q8IW41" "MAP kinase-activated protein kinase 5 OS=Homo sapiens OX=9606 GN=MAPKAPK5 PE=1 SV=2" "0.000" "False" "4.376" "4" "2" "2" "1" "473" "54.2" "7.78" "3.14" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8550" "ENSG00000089022" "MAPKAPK5" "B3KVA5; hsa:8550; O60491; Q86X46; Q8IW41; Q9BVX9; Q9UG86" "MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation" "MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2068779671623766038" "False" "High" "IsMasterProtein" "A6NJ78" "12S rRNA N4-methylcytidine (m4C) methyltransferase OS=Homo sapiens OX=9606 GN=METTL15 PE=1 SV=1" "0.000" "False" "4.374" "3" "1" "1" "1" "407" "46.1" "8.62" "4.03" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf01795" "196074" "ENSG00000169519" "METTL15" "A6NJ78; A8MRS5; B7WNU2; hsa:196074; Q3MHD3; Q8N601; Q8NBA7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962513167934133051" "False" "High" "IsMasterProtein" "P49643" "DNA primase large subunit OS=Homo sapiens OX=9606 GN=PRIM2 PE=1 SV=2" "0.000" "False" "4.360" "2" "1" "1" "1" "509" "58.8" "7.91" "3.34" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04104" "5558" "ENSG00000146143" "PRIM2" "hsa:5558; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413" "Defective pyroptosis; Polymerase switching on the C-strand of the telomere; Polymerase switching; Activation of the pre-replicative complex; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Telomere C-strand synthesis initiation; DNA replication initiation; Removal of the Flap Intermediate" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "12" "0" "1.097" "1.003" "1.080" "0.892" "1.177" "0.979" "0.941" "1.007" "2.412" "41.6" "45.7" "41.8" "45.0" "37.1" "49.0" "40.7" "39.2" "41.9" "100.4" "" "" "" "" "" "" "" "" "" "" "37.6" "35.2" "32.3" "30.3" "31.0" "41.8" "34.6" "28.3" "28.3" "100.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3605806557374244366" "False" "High" "IsMasterProtein" "Q99766" "ATP synthase subunit s, mitochondrial OS=Homo sapiens OX=9606 GN=DMAC2L PE=1 SV=4" "0.000" "False" "4.356" "9" "2" "2" "2" "200" "23.2" "7.90" "4.61" "2" "other metabolic processes;transport" "other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "" "27109" "ENSG00000125375" "DMAC2L" "A0A2R8YDJ1; A0A5K1VW60; A8K1U3; D9N156; hsa:27109; Q8WWX3; Q96F77; Q99766" "Cristae formation; Formation of ATP by chemiosmotic coupling" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "4" "0" "1.123" "0.976" "1.101" "1.132" "1.067" "1.026" "1.142" "0.993" "0.959" "80.7" "90.6" "78.8" "88.9" "91.4" "86.1" "82.8" "92.2" "80.2" "77.4" "" "" "" "" "" "" "" "" "" "" "72.9" "69.9" "60.9" "59.8" "76.2" "73.5" "70.2" "66.7" "54.1" "77.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "530217312894151981" "False" "High" "IsMasterProtein" "Cont_P00978" "Protein AMBP OS=Bos taurus OX=9913 GN=AMBP PE=1 SV=2" "0.000" "True" "4.352" "6" "2" "2" "2" "352" "39.2" "7.62" "4.80" "2" "" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00014, Pf00061" "280996" "" "AMBP" "bta:280996; P00978; P35420; Q28020; Q3SZZ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3949489536824211546" "False" "High" "IsMasterProtein" "O15162" "Phospholipid scramblase 1 OS=Homo sapiens OX=9606 GN=PLSCR1 PE=1 SV=1" "0.000" "False" "4.343" "4" "1" "1" "1" "318" "35.0" "4.94" "2.87" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;transporter activity;nucleic acid binding activity;other molecular function" "Pf03803" "5359" "ENSG00000188313" "PLSCR1" "B2R8H8; B4DTE8; hsa:5359; O15162" "" "EGF/EGFR signaling pathway; Complement system in neuronal development and plasticity" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594360635056461095" "False" "High" "IsMasterProtein" "O75648" "Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens OX=9606 GN=TRMU PE=1 SV=2" "0.000" "False" "4.341" "3" "1" "1" "1" "421" "47.7" "8.03" "3.23" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf03054, Pf20258, Pf20259" "55687" "ENSG00000100416" "TRMU" "A8K3U7; hsa:55687; O75648; Q05C99; Q5W9C8; Q66K31; Q6ICC3; Q9NWC1" "tRNA modification in the mitochondrion" "" "1" "0" "1.101" "0.926" "1.591" "1.235" "0.984" "1.163" "1.280" "1.391" "1.206" "47.9" "52.7" "44.4" "76.2" "59.2" "47.2" "55.7" "61.3" "66.6" "57.8" "" "" "" "" "" "" "" "" "" "" "43.2" "40.7" "34.3" "51.3" "49.3" "40.2" "47.3" "44.4" "44.9" "57.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2638301692080516805" "False" "High" "IsMasterProtein" "O95817" "BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3" "0.000" "False" "4.335" "2" "1" "2" "1" "575" "61.6" "6.95" "3.27" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf02179" "9531" "ENSG00000151929" "BAG3" "A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120" "Regulation of HSF1-mediated heat shock response" "Cell interactions of the pancreatic cancer microenvironment" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8346227288620115762" "False" "High" "IsMasterProtein" "Q86TN4" "tRNA 2'-phosphotransferase 1 OS=Homo sapiens OX=9606 GN=TRPT1 PE=1 SV=2" "0.000" "False" "4.332" "4" "1" "1" "1" "253" "27.7" "9.98" "3.29" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01885" "83707" "ENSG00000149743" "TRPT1" "A8MU17; A8MYC9; F5H2B2; hsa:83707; Q86TN4; Q9BSB9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6470413876399214347" "False" "High" "IsMasterProtein" "Q9NSK7" "Protein C19orf12 OS=Homo sapiens OX=9606 GN=C19orf12 PE=1 SV=4" "0.000" "False" "4.329" "7" "1" "1" "1" "141" "15.0" "5.90" "2.76" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8914003618785624230" "False" "High" "IsMasterProtein" "O75934" "Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1" "0.000" "False" "4.318" "5" "1" "1" "1" "225" "26.1" "5.66" "3.99" "1" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "" "Pf05700" "10286" "ENSG00000116752" "BCAS2" "hsa:10286; O75934; Q6FGS0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.049" "0.869" "0.987" "0.966" "1.076" "0.964" "0.876" "1.007" "0.979" "31.8" "33.4" "27.7" "31.4" "30.7" "34.2" "30.7" "27.9" "32.0" "31.1" "" "" "" "" "" "" "" "" "" "" "28.7" "25.8" "21.4" "21.2" "25.6" "29.2" "26.0" "20.2" "21.6" "31.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7428234003778738305" "False" "High" "IsMasterProtein" "Q9BRT2" "Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1" "0.000" "False" "4.316" "10" "1" "1" "1" "126" "14.9" "7.37" "2.88" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf20180" "84300" "ENSG00000137288" "UQCC2" "B2R4I0; Q9BRT2" "" "Mitochondrial complex III assembly" "1" "0" "1.149" "1.189" "1.620" "1.724" "1.746" "1.196" "1.559" "1.785" "1.114" "19.0" "21.8" "22.5" "30.7" "32.7" "33.1" "22.7" "29.5" "33.8" "21.1" "" "" "" "" "" "" "" "" "" "" "17.1" "16.8" "17.4" "20.7" "27.3" "28.2" "19.2" "21.4" "22.8" "21.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2648921608470054018" "False" "High" "IsMasterProtein" "Q96L92" "Sorting nexin-27 OS=Homo sapiens OX=9606 GN=SNX27 PE=1 SV=2" "0.000" "False" "4.284" "2" "1" "3" "1" "541" "61.2" "6.49" "6.82" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595, Pf00787, Pf00788" "81609" "ENSG00000143376" "SNX27" "hsa:81609; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q96L92; Q9H3K8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9173522146093415156" "False" "High" "IsMasterProtein" "Q9P0J7" "E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2" "0.000" "False" "4.271" "2" "1" "1" "1" "381" "41.9" "5.66" "3.99" "1" "cell-cell signaling" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00569, Pf05605" "56888" "ENSG00000176407" "KCMF1" "Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9P0J7; Q9UFE8" "Neutrophil degranulation" "" "1" "0" "0.971" "0.781" "1.049" "1.047" "0.811" "1.197" "0.944" "0.843" "1.319" "115.9" "112.5" "90.5" "121.5" "121.3" "94.0" "138.7" "109.4" "97.7" "152.8" "" "" "" "" "" "" "" "" "" "" "104.6" "86.8" "70.0" "81.8" "101.2" "80.2" "117.6" "79.2" "65.9" "152.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7682312476163043373" "False" "High" "IsMasterProtein" "P82914" "Small ribosomal subunit protein uS15m OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1" "0.000" "False" "4.270" "6" "2" "3" "2" "257" "29.8" "10.48" "6.13" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00312" "64960" "ENSG00000116898" "MRPS15" "B2RD82; hsa:64960; P82914; Q9H2K1" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.960" "0.849" "1.056" "0.942" "0.849" "0.818" "0.886" "0.822" "1.261" "148.5" "142.5" "126.1" "156.7" "139.9" "126.0" "121.5" "131.5" "122.1" "187.1" "" "" "" "" "" "" "" "" "" "" "134.0" "109.9" "97.5" "105.5" "116.7" "107.5" "103.0" "95.2" "82.3" "187.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516422207583123109" "False" "High" "IsMasterProtein" "Q9NUD5" "Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2" "0.000" "False" "4.269" "2" "1" "1" "1" "403" "43.5" "8.53" "3.10" "1" "stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "85364" "ENSG00000247315" "ZCCHC3" "hsa:85364; Q3B7J3; Q6NT79; Q9NUD5" "" "" "0" "0" "0.986" "0.920" "1.026" "0.966" "0.904" "0.864" "0.803" "0.939" "0.932" "67.7" "66.8" "62.3" "69.5" "65.4" "61.3" "58.5" "54.4" "63.6" "63.1" "" "" "" "" "" "" "" "" "" "" "61.1" "51.5" "48.2" "46.8" "54.6" "52.3" "49.6" "39.4" "42.9" "63.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4426217636715391666" "False" "High" "IsMasterProtein" "Q9H9F9" "Actin-related protein 5 OS=Homo sapiens OX=9606 GN=ACTR5 PE=1 SV=2" "0.000" "False" "4.255" "2" "1" "1" "1" "607" "68.3" "5.27" "2.95" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00022" "79913" "ENSG00000101442" "ACTR5" "hsa:79913; Q86WF7; Q8IUY5; Q8N724; Q9BRN0; Q9BVB7; Q9H9F9" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "1.457" "1.914" "1.331" "1.556" "1.619" "1.530" "1.352" "1.635" "2.146" "12.4" "18.0" "23.7" "16.5" "19.2" "20.0" "18.9" "16.7" "20.2" "26.5" "" "" "" "" "" "" "" "" "" "" "11.2" "13.9" "18.3" "11.1" "16.0" "17.1" "16.0" "12.1" "13.6" "26.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7917759671781486439" "False" "High" "IsMasterProtein" "Q13627" "Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2" "0.000" "False" "4.254" "1" "1" "1" "1" "763" "85.5" "8.75" "3.51" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1859" "ENSG00000157540" "DYRK1A" "hsa:1859; O60769; Q13627; Q92582; Q92810; Q9UNM5" "G0 and Early G1" "T cell receptor and co-stimulatory signaling; DYRK1A involvement regarding cell proliferation in brain development" "3" "0" "1.332" "1.009" "0.996" "0.905" "0.839" "1.029" "1.102" "0.923" "1.312" "33.5" "44.6" "33.8" "33.4" "30.3" "28.1" "34.5" "36.9" "30.9" "44.0" "" "" "" "" "" "" "" "" "" "" "30.2" "34.4" "26.2" "22.5" "25.3" "24.0" "29.2" "26.7" "20.9" "44.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2740233867527592751" "False" "High" "IsMasterProtein" "Q5M775" "Cytospin-B OS=Homo sapiens OX=9606 GN=SPECC1 PE=1 SV=1" "0.000" "False" "4.239" "1" "2" "2" "1" "1068" "118.5" "6.70" "5.63" "2" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00307" "92521" "ENSG00000128487" "SPECC1" "B4DHH0; B7WNS8; hsa:92521; Q5IBP1; Q5IBP2; Q5IBP3; Q5IBP4; Q5M772; Q5M773; Q5M774; Q5M775; Q86XT8; Q8N4U4; Q8WU84; Q9HCQ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695777178307527150" "False" "High" "IsMasterProtein" "Q9BZL1" "Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1" "0.000" "False" "4.223" "12" "1" "1" "1" "73" "8.5" "8.44" "2.92" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00240" "59286" "ENSG00000198258" "UBL5" "hsa:59286; Q2NL89; Q9BZL1" "mRNA Splicing - Major Pathway" "" "1" "0" "1.008" "0.641" "1.012" "1.014" "0.581" "1.020" "0.880" "0.773" "1.546" "113.7" "114.6" "72.9" "115.0" "115.4" "66.1" "116.0" "100.1" "87.9" "175.8" "" "" "" "" "" "" "" "" "" "" "102.7" "88.4" "56.4" "77.5" "96.2" "56.4" "98.4" "72.5" "59.3" "175.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7925293955382701162" "False" "High" "IsMasterProtein" "Q96JN8" "Neuralized-like protein 4 OS=Homo sapiens OX=9606 GN=NEURL4 PE=1 SV=2" "0.000" "False" "4.223" "1" "1" "1" "1" "1562" "166.8" "5.86" "3.18" "1" "" "cytoskeleton;other cell component" "other molecular function" "Pf07177" "84461" "ENSG00000215041; ENSG00000288301" "NEURL4" "hsa:84461; Q6GPI8; Q96IU9; Q96JN8; Q9H0B0" "" "" "0" "0" "1.182" "1.210" "0.962" "1.089" "1.110" "1.035" "1.286" "1.089" "1.374" "83.8" "99.0" "101.3" "80.6" "91.2" "93.0" "86.7" "107.7" "91.2" "115.1" "" "" "" "" "" "" "" "" "" "" "75.6" "76.3" "78.4" "54.3" "76.1" "79.3" "73.6" "77.9" "61.5" "115.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7832305992449282077" "False" "High" "IsMasterProtein" "Q8NHJ6" "Leukocyte immunoglobulin-like receptor subfamily B member 4 OS=Homo sapiens OX=9606 GN=LILRB4 PE=1 SV=3" "0.000" "False" "4.222" "5" "2" "2" "2" "448" "49.3" "6.67" "2.85" "2" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00047, Pf13895" "11006" "ENSG00000186818; ENSG00000275730" "LILRB4" "A8MVL8; hsa:11006; O15468; O75021; Q6FGQ9; Q8N1C7; Q8NHJ6; Q8NHL5" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782034775898615298" "False" "High" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "0.000" "False" "4.218" "7" "2" "3" "2" "199" "23.6" "9.01" "8.58" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "mRNA Splicing - Major Pathway" "" "1" "0" "1.009" "0.917" "1.006" "0.868" "0.809" "0.869" "1.013" "0.793" "0.513" "319.5" "322.3" "293.2" "321.4" "277.4" "258.4" "277.7" "323.6" "253.4" "163.8" "" "" "" "" "" "" "" "" "" "" "288.4" "248.6" "226.7" "216.5" "231.4" "220.5" "235.6" "234.2" "170.9" "163.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4348390061636338319" "False" "High" "IsMasterProtein" "Q9HAW4" "Claspin OS=Homo sapiens OX=9606 GN=CLSPN PE=1 SV=3" "0.000" "False" "4.216" "1" "1" "1" "1" "1339" "151.0" "4.82" "3.20" "1" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "63967" "ENSG00000092853" "CLSPN" "A6NFL4; hsa:63967; Q1RMC6; Q2KHM3; Q5VYG0; Q6P6H5; Q8IWI1; Q9HAW4" "Activation of ATR in response to replication stress; Ub-specific processing proteases; Processing of DNA double-strand break ends; Apoptotic cleavage of cellular proteins" "" "4" "0" "0.923" "0.742" "0.850" "0.884" "0.830" "0.788" "0.897" "0.866" "1.076" "27.5" "25.4" "20.4" "23.3" "24.3" "22.8" "21.6" "24.6" "23.8" "29.6" "" "" "" "" "" "" "" "" "" "" "24.8" "19.6" "15.8" "15.7" "20.3" "19.5" "18.4" "17.8" "16.1" "29.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5739848343521747817" "False" "High" "IsMasterProtein" "Q5TEU4" "Arginine-hydroxylase NDUFAF5, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF5 PE=1 SV=1" "0.000" "False" "4.211" "6" "2" "2" "2" "345" "38.9" "6.57" "5.28" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf08241" "79133" "ENSG00000101247" "NDUFAF5" "A8K166; hsa:79133; Q5TEU4; Q6GPH3; Q9H6F4" "Complex I biogenesis" "" "1" "0" "0.990" "1.049" "1.071" "0.957" "0.991" "0.897" "1.144" "1.066" "0.544" "80.7" "79.9" "84.7" "86.4" "77.3" "79.9" "72.4" "92.3" "86.0" "43.9" "" "" "" "" "" "" "" "" "" "" "72.9" "61.6" "65.5" "58.2" "64.5" "68.2" "61.4" "66.8" "58.0" "43.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2486972886246464504" "False" "High" "IsMasterProtein" "O00221" "NF-kappa-B inhibitor epsilon OS=Homo sapiens OX=9606 GN=NFKBIE PE=1 SV=3" "0.000" "False" "4.197" "4" "1" "1" "1" "500" "52.8" "6.68" "3.71" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00023" "4794" "ENSG00000146232" "NFKBIE" "hsa:4794; O00221; Q5T9V9" "Activation of NF-kappaB in B cells" "TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19" "7" "0" "1.320" "1.174" "1.456" "1.066" "1.142" "1.048" "1.139" "1.371" "1.723" "18.4" "24.2" "21.6" "26.7" "19.6" "21.0" "19.2" "20.9" "25.2" "31.6" "" "" "" "" "" "" "" "" "" "" "16.6" "18.7" "16.7" "18.0" "16.3" "17.9" "16.3" "15.1" "17.0" "31.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751278663907923034" "False" "High" "IsMasterProtein" "Q9UFG5" "UPF0449 protein C19orf25 OS=Homo sapiens OX=9606 GN=C19orf25 PE=1 SV=2" "0.000" "False" "4.196" "13" "2" "2" "2" "118" "12.9" "5.07" "5.86" "2" "" "" "" "Pf15136" "148223" "ENSG00000119559" "C19orf25" "B3KQN6; hsa:148223; Q8N9R7; Q8WV94; Q9UFG5" "" "" "0" "0" "0.984" "0.964" "1.141" "0.966" "0.924" "0.991" "1.129" "0.957" "0.649" "323.2" "318.1" "311.5" "368.9" "312.4" "298.6" "320.4" "365.0" "309.4" "209.7" "" "" "" "" "" "" "" "" "" "" "291.8" "245.4" "240.9" "248.4" "260.6" "254.8" "271.8" "264.1" "208.7" "209.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651135355279393622" "False" "High" "IsMasterProtein" "Q8N2G8" "GH3 domain-containing protein OS=Homo sapiens OX=9606 GN=GHDC PE=1 SV=2" "0.000" "False" "4.182" "3" "2" "2" "2" "530" "57.5" "7.88" "5.21" "2" "" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03321" "84514" "ENSG00000167925" "GHDC" "B4DQS4; E9PDB5; hsa:84514; Q8N2G8; Q9BXM6" "Neutrophil degranulation" "" "1" "0" "1.107" "0.830" "1.053" "0.833" "1.047" "1.071" "0.817" "0.476" "0.994" "34.8" "38.5" "28.8" "36.6" "28.9" "36.4" "37.2" "28.4" "16.5" "34.6" "" "" "" "" "" "" "" "" "" "" "31.4" "29.7" "22.3" "24.6" "24.1" "31.0" "31.6" "20.5" "11.2" "34.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2393292125676734128" "False" "High" "IsMasterProtein" "Q8IWY9" "Codanin-1 OS=Homo sapiens OX=9606 GN=CDAN1 PE=1 SV=4" "0.000" "False" "4.181" "1" "1" "1" "1" "1227" "134.0" "6.77" "2.87" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15296" "146059" "ENSG00000140326" "CDAN1" "hsa:146059; Q6NYD0; Q7Z7L5; Q8IWY9; Q969N3" "" "" "0" "0" "0.935" "0.693" "0.946" "0.849" "0.704" "0.960" "0.819" "0.719" "1.452" "46.0" "43.0" "31.9" "43.5" "39.0" "32.4" "44.1" "37.7" "33.0" "66.7" "" "" "" "" "" "" "" "" "" "" "41.5" "33.2" "24.6" "29.3" "32.5" "27.6" "37.4" "27.3" "22.3" "66.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8485687817967320227" "False" "High" "IsMasterProtein" "Q96ES7" "SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1" "0.000" "False" "4.172" "4" "1" "1" "1" "293" "33.2" "8.10" "3.27" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07039" "112869" "ENSG00000176476" "SGF29" "hsa:112869; Q96ES7; Q96MF5" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "2" "0" "0.934" "0.953" "1.044" "1.076" "1.147" "1.005" "1.001" "1.315" "1.329" "62.5" "58.4" "59.6" "65.2" "67.3" "71.7" "62.8" "62.6" "82.2" "83.1" "" "" "" "" "" "" "" "" "" "" "56.4" "45.1" "46.1" "43.9" "56.1" "61.2" "53.3" "45.3" "55.4" "83.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5038635126872872861" "False" "High" "IsMasterProtein" "O15015" "Zinc finger protein 646 OS=Homo sapiens OX=9606 GN=ZNF646 PE=1 SV=2" "0.000" "False" "4.168" "1" "2" "2" "2" "1832" "200.7" "7.21" "6.42" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "9726" "ENSG00000167395" "ZNF646" "hsa:9726; O15015; Q8IVD8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7385395348648311511" "False" "High" "IsMasterProtein" "Q9HCP0" "Casein kinase I isoform gamma-1 OS=Homo sapiens OX=9606 GN=CSNK1G1 PE=1 SV=1" "0.001" "False" "4.161" "2" "1" "2" "1" "422" "48.5" "9.01" "7.29" "1" "cell-cell signaling;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00069, Pf12605" "53944" "ENSG00000169118" "CSNK1G1" "hsa:53944; Q5JPH1; Q96AE9; Q9HCP0; Q9HCP1" "" "Wnt signaling pathway; Hedgehog signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6205796797264401430" "False" "High" "IsMasterProtein" "Q96DH6" "RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1" "0.001" "False" "4.156" "7" "2" "2" "2" "328" "35.2" "8.48" "3.04" "2" "developmental processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "124540" "ENSG00000153944" "MSI2" "hsa:124540; Q7Z6M7; Q8N9T4; Q96DH6" "RHOBTB2 GTPase cycle" "" "1" "0" "1.195" "0.866" "1.210" "0.969" "1.035" "1.038" "0.873" "1.215" "1.432" "91.0" "108.7" "78.8" "110.1" "88.2" "94.1" "94.5" "79.4" "110.5" "130.3" "" "" "" "" "" "" "" "" "" "" "82.1" "83.8" "61.0" "74.1" "73.5" "80.3" "80.1" "57.5" "74.6" "130.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3086265819139452668" "False" "High" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "0.001" "False" "4.153" "3" "1" "1" "1" "563" "61.2" "6.48" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "XBP1(S) activates chaperone genes" "VEGFA-VEGFR2 signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "Not Found" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "-1246556582121742605" "False" "High" "IsMasterProtein" "Q9P253" "Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2" "0.001" "False" "4.149" "1" "1" "1" "1" "973" "110.1" "6.07" "3.23" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05131" "57617" "ENSG00000104142" "VPS18" "hsa:57617; Q8TCG0; Q96DI3; Q9H268; Q9P253" "SARS-CoV-2 modulates autophagy" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "3" "0" "0.859" "0.679" "0.876" "0.812" "0.583" "1.120" "0.674" "0.928" "3.411" "22.1" "19.0" "15.0" "19.4" "18.0" "12.9" "24.8" "14.9" "20.5" "75.5" "" "" "" "" "" "" "" "" "" "" "20.0" "14.7" "11.6" "13.1" "15.0" "11.0" "21.0" "10.8" "13.9" "75.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6705073720058711891" "False" "High" "IsMasterProtein" "Q96BP2" "Small ribosomal subunit protein mS37 OS=Homo sapiens OX=9606 GN=CHCHD1 PE=1 SV=1" "0.001" "False" "4.148" "9" "1" "1" "1" "118" "13.5" "10.21" "3.32" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "" "Pf06747" "118487" "ENSG00000172586" "CHCHD1" "hsa:118487; Q96BP2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-984434890743612814" "False" "High" "IsMasterProtein" "Q96A57" "Transmembrane protein 230 OS=Homo sapiens OX=9606 GN=TMEM230 PE=1 SV=1" "0.001" "False" "4.148" "10" "1" "1" "1" "120" "13.2" "9.31" "2.23" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf05915" "29058" "ENSG00000089063" "TMEM230" "B2RDM8; D3DVZ9; hsa:29058; Q0VGC8; Q5TDS5; Q96A57; Q96ES2; Q9P0A7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7880299812085229449" "False" "High" "IsMasterProtein" "P11049" "Leukocyte antigen CD37 OS=Homo sapiens OX=9606 GN=CD37 PE=1 SV=2" "0.001" "False" "4.145" "3" "1" "1" "1" "281" "31.7" "7.94" "4.23" "1" "" "plasma membrane" "" "Pf00335" "951" "ENSG00000104894" "CD37" "B4DVC1; hsa:951; P11049; Q3KPF9" "" "TYROBP causal network in microglia" "1" "0" "1.077" "0.980" "1.007" "0.983" "0.757" "1.065" "1.240" "0.872" "0.483" "324.4" "349.2" "318.0" "326.6" "318.9" "245.6" "345.5" "402.2" "282.8" "156.6" "" "" "" "" "" "" "" "" "" "" "292.8" "269.4" "246.0" "219.9" "266.0" "209.7" "293.1" "291.1" "190.7" "156.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167076474534668157" "False" "High" "IsMasterProtein" "Q15398" "Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2" "0.001" "False" "4.137" "2" "2" "2" "2" "846" "95.1" "9.00" "5.62" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf03359" "9787" "ENSG00000126787" "DLGAP5" "A8MTM6; B4DRM8; hsa:9787; Q15398; Q86T11; Q8NG58" "NOTCH3 Intracellular Domain Regulates Transcription" "Complement system in neuronal development and plasticity" "2" "0" "0.913" "1.571" "1.314" "1.005" "1.386" "1.133" "1.142" "1.624" "2.208" "39.4" "36.0" "62.0" "51.8" "39.6" "54.7" "44.7" "45.0" "64.0" "87.1" "" "" "" "" "" "" "" "" "" "" "35.6" "27.8" "47.9" "34.9" "33.1" "46.7" "37.9" "32.6" "43.2" "87.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2063418146080875135" "False" "High" "IsMasterProtein" "O76094" "Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3" "0.001" "False" "4.133" "1" "1" "1" "1" "671" "74.6" "9.26" "3.02" "1" "other biological processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08492, Pf13181, Pf17004" "6731" "ENSG00000174780" "SRP72" "G5E9Z8; hsa:6731; O76094; Q7Z3C0" "SRP-dependent cotranslational protein targeting to membrane" "" "1" "0" "1.037" "0.677" "0.993" "1.020" "0.748" "0.824" "0.836" "0.683" "2.537" "22.9" "23.8" "15.5" "22.8" "23.4" "17.1" "18.9" "19.2" "15.7" "58.1" "" "" "" "" "" "" "" "" "" "" "20.7" "18.3" "12.0" "15.3" "19.5" "14.6" "16.0" "13.9" "10.6" "58.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684474116770674977" "False" "High" "IsMasterProtein" "Q9NW68" "BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1" "0.001" "False" "4.098" "2" "1" "1" "1" "430" "47.1" "4.49" "3.64" "1" "" "other cell component" "" "Pf03909" "55108" "ENSG00000160058" "BSDC1" "B4DMS7; B4DTI7; B4DTP7; B4E2X8; hsa:55108; Q49AT8; Q68DY6; Q6IAA3; Q6MZK1; Q6UXS1; Q9HAL9; Q9NW68" "" "" "0" "0" "0.860" "1.000" "1.047" "1.051" "1.028" "1.092" "1.157" "1.029" "1.037" "143.9" "123.8" "143.8" "150.6" "151.2" "147.9" "157.2" "166.4" "148.0" "149.2" "" "" "" "" "" "" "" "" "" "" "129.9" "95.5" "111.3" "101.4" "126.1" "126.2" "133.3" "120.5" "99.8" "149.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8151909637929937359" "False" "High" "IsMasterProtein" "Q14554" "Protein disulfide-isomerase A5 OS=Homo sapiens OX=9606 GN=PDIA5 PE=1 SV=1" "0.001" "False" "4.093" "2" "1" "1" "1" "519" "59.6" "7.91" "4.65" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00085" "10954" "ENSG00000065485" "PDIA5" "D3DN95; hsa:10954; Q14554; Q9BV43" "XBP1(S) activates chaperone genes" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7144530855907264984" "False" "High" "IsMasterProtein" "Q9H6R4" "Nucleolar protein 6 OS=Homo sapiens OX=9606 GN=NOL6 PE=1 SV=2" "0.001" "False" "4.087" "1" "1" "1" "1" "1146" "127.5" "7.64" "2.99" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf03813, Pf17403, Pf17404, Pf17405, Pf17406, Pf17407" "65083" "ENSG00000165271" "NOL6" "hsa:65083; Q5T5M3; Q5T5M4; Q7L4G6; Q8N6I0; Q8TEY9; Q8TEZ0; Q8TEZ1; Q9H675; Q9H6R4" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "1.127" "1.107" "1.111" "0.970" "1.048" "0.939" "0.901" "0.966" "1.436" "66.2" "74.6" "73.3" "73.5" "64.2" "69.4" "62.1" "59.6" "63.9" "95.0" "" "" "" "" "" "" "" "" "" "" "59.7" "57.6" "56.7" "49.5" "53.6" "59.2" "52.7" "43.2" "43.1" "95.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142056770574276442" "False" "High" "IsMasterProtein" "Q96T58" "Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1" "0.001" "False" "4.086" "0" "1" "1" "1" "3664" "402.0" "7.64" "2.86" "1" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf07744, Pf20808, Pf20809, Pf20810" "23013" "ENSG00000065526" "SPEN" "hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556" "RHOBTB1 GTPase cycle" "Notch signaling pathway" "2" "0" "0.794" "0.979" "1.007" "0.776" "1.007" "0.857" "0.777" "0.947" "2.407" "64.6" "51.3" "63.3" "65.1" "50.1" "65.1" "55.4" "50.2" "61.2" "155.6" "" "" "" "" "" "" "" "" "" "" "58.3" "39.6" "48.9" "43.8" "41.8" "55.6" "47.0" "36.3" "41.3" "155.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5364683920046459506" "False" "High" "IsMasterProtein" "O75340" "Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1" "0.001" "False" "4.080" "6" "1" "1" "1" "191" "21.9" "5.40" "2.87" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13499" "10016" "ENSG00000249915" "PDCD6" "B2RD16; E7ESR3; hsa:10016; O75340; Q2YDC2; Q5TZS0" "" "Epithelial to mesenchymal transition in colorectal cancer" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1981774019348378929" "False" "High" "IsMasterProtein" "P0DOY2" "Immunoglobulin lambda constant 2 OS=Homo sapiens OX=9606 GN=IGLC2 PE=1 SV=1" "0.001" "False" "4.056" "9" "1" "2" "1" "106" "11.3" "7.24" "4.12" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07654" "" "ENSG00000211677" "IGLC2" "A0A075B6K9; A0M8Q4; P0CG05; P0CG06; P0DOY2; P80423" "FCERI mediated NF-kB activation; Cell surface interactions at the vascular wall; FCGR activation; Role of LAT2/NTAL/LAB on calcium mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; CD22 mediated BCR regulation; Potential therapeutics for SARS; Regulation of Complement cascade" "" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5836561258245124912" "False" "High" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "0.001" "False" "4.040" "6" "2" "2" "2" "394" "44.2" "9.09" "4.85" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Reversal of alkylation damage by DNA dioxygenases" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.180" "1.298" "1.478" "1.230" "1.404" "1.164" "1.123" "1.464" "2.079" "41.0" "48.3" "53.2" "60.5" "50.4" "57.5" "47.7" "46.0" "60.0" "85.2" "" "" "" "" "" "" "" "" "" "" "37.0" "37.3" "41.1" "40.8" "42.0" "49.1" "40.5" "33.3" "40.5" "85.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1804572452754127455" "False" "High" "IsMasterProtein" "Q96AW1" "WW domain binding protein VOPP1 OS=Homo sapiens OX=9606 GN=VOPP1 PE=1 SV=1" "0.001" "False" "4.031" "5" "1" "2" "1" "172" "19.2" "8.40" "5.59" "1" "" "other membranes;other cytoplasmic organelle" "other molecular function" "" "81552" "ENSG00000154978" "VOPP1" "B0AZU1; B2RAT4; B3KS72; C9JWR3; hsa:81552; Q6FIE3; Q8NBN8; Q96AW1; Q96RE5; Q9H0W4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7346476942521402077" "False" "High" "IsMasterProtein" "Q9BUT9" "MAPK regulated corepressor interacting protein 2 OS=Homo sapiens OX=9606 GN=MCRIP2 PE=1 SV=2" "0.001" "False" "4.029" "7" "1" "2" "1" "160" "17.8" "9.41" "6.85" "1" "" "nucleus;other cell component" "" "Pf14799" "84331" "ENSG00000172366" "MCRIP2" "hsa:84331; Q969E9; Q96KV8; Q9BUT9" "" "" "0" "0" "1.014" "0.926" "1.381" "1.093" "1.015" "1.101" "1.156" "1.064" "1.135" "87.1" "88.3" "80.7" "120.3" "95.2" "88.4" "95.9" "100.7" "92.7" "98.8" "" "" "" "" "" "" "" "" "" "" "78.6" "68.1" "62.4" "81.0" "79.4" "75.5" "81.4" "72.9" "62.5" "98.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6246281522193444266" "False" "High" "IsMasterProtein" "O60573" "Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1" "0.001" "False" "4.029" "4" "1" "2" "1" "245" "28.3" "8.88" "6.42" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "9470" "ENSG00000135930" "EIF4E2" "B8ZZJ9; hsa:9470; O60573; O75349" "ISG15 antiviral mechanism" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2026118880241708351" "False" "High" "IsMasterProtein" "A5PLN9" "Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2" "0.001" "False" "4.026" "2" "1" "1" "1" "417" "46.5" "5.60" "3.26" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06159" "80006" "ENSG00000113597" "TRAPPC13" "A5PLN9; hsa:80006; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3" "RAB GEFs exchange GTP for GDP on RABs" "" "1" "0" "0.834" "0.774" "0.807" "0.952" "0.797" "0.965" "0.790" "0.878" "2.851" "99.8" "83.2" "77.3" "80.5" "95.1" "79.5" "96.3" "78.8" "87.6" "284.5" "" "" "" "" "" "" "" "" "" "" "90.1" "64.2" "59.8" "54.2" "79.3" "67.9" "81.7" "57.0" "59.1" "284.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945002004547854697" "False" "High" "IsMasterProtein" "Q8N7B6" "PACRG-like protein OS=Homo sapiens OX=9606 GN=PACRGL PE=1 SV=2" "0.001" "False" "4.023" "5" "1" "1" "1" "248" "27.1" "9.67" "2.80" "1" "" "" "" "Pf10274" "133015" "ENSG00000163138" "PACRGL" "B2RDB9; B4DFF8; B4DMN7; hsa:133015; Q8N7B6; Q8TBA8" "" "" "0" "0" "0.920" "1.105" "1.100" "1.101" "1.013" "0.946" "0.895" "1.097" "0.869" "49.9" "45.9" "55.1" "54.8" "54.9" "50.5" "47.2" "44.6" "54.7" "43.4" "" "" "" "" "" "" "" "" "" "" "45.0" "35.4" "42.6" "36.9" "45.8" "43.1" "40.0" "32.3" "36.9" "43.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4170065577155678868" "False" "High" "IsMasterProtein" "Q5QP82" "DDB1- and CUL4-associated factor 10 OS=Homo sapiens OX=9606 GN=DCAF10 PE=1 SV=1" "0.001" "False" "4.023" "5" "2" "2" "2" "559" "60.5" "7.50" "2.99" "2" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "79269" "ENSG00000122741" "DCAF10" "A4VCJ5; hsa:79269; Q32NE2; Q5QP82; Q8N2Q5; Q96ET5; Q9BTQ5; Q9H5P6" "Neddylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2132288438487461579" "False" "High" "IsMasterProtein" "Q9BV68" "E3 ubiquitin-protein ligase RNF126 OS=Homo sapiens OX=9606 GN=RNF126 PE=1 SV=2" "0.001" "False" "4.021" "3" "1" "2" "1" "311" "33.8" "5.47" "7.01" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13639, Pf14369" "55658" "ENSG00000070423" "RNF126" "hsa:55658; Q9BV68; Q9NWX1" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.879" "0.759" "1.180" "0.931" "0.773" "0.920" "0.801" "0.826" "1.918" "158.5" "139.2" "120.3" "187.1" "147.6" "122.5" "145.8" "126.9" "130.9" "304.0" "" "" "" "" "" "" "" "" "" "" "143.1" "107.4" "93.1" "126.0" "123.1" "104.5" "123.7" "91.8" "88.3" "304.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527678404860705700" "False" "High" "IsMasterProtein" "Q96K21" "Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3" "0.001" "False" "4.010" "4" "2" "2" "2" "471" "51.5" "5.73" "5.67" "2" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf01363" "84936" "ENSG00000166140" "ZFYVE19" "B3KVB2; C9JNF4; H3BUF9; hsa:84936; Q86WC2; Q8WU96; Q96K21" "" "" "0" "0" "1.059" "1.124" "1.266" "1.271" "0.966" "1.186" "1.172" "1.048" "0.942" "66.7" "70.6" "74.9" "84.5" "84.8" "64.4" "79.1" "78.2" "69.9" "62.8" "" "" "" "" "" "" "" "" "" "" "60.2" "54.5" "58.0" "56.9" "70.7" "55.0" "67.1" "56.6" "47.1" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853825877774435955" "False" "High" "IsMasterProtein" "Q96HQ2" "CDKN2AIP N-terminal-like protein OS=Homo sapiens OX=9606 GN=CDKN2AIPNL PE=1 SV=1" "0.001" "False" "4.009" "9" "1" "1" "1" "116" "13.2" "5.00" "3.87" "1" "" "" "" "Pf11952" "91368" "ENSG00000237190" "CDKN2AIPNL" "hsa:91368; Q8WVE3; Q96HQ2" "" "" "0" "0" "1.299" "0.938" "1.216" "1.108" "1.344" "1.169" "0.802" "1.229" "0.913" "52.7" "68.5" "49.5" "64.1" "58.4" "70.9" "61.7" "42.3" "64.8" "48.1" "" "" "" "" "" "" "" "" "" "" "47.6" "52.9" "38.3" "43.2" "48.7" "60.5" "52.3" "30.6" "43.7" "48.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8108900187098047619" "False" "High" "IsMasterProtein" "Q9H6U6" "BCAS3 microtubule associated cell migration factor OS=Homo sapiens OX=9606 GN=BCAS3 PE=1 SV=3" "0.001" "False" "4.002" "1" "1" "1" "1" "928" "101.2" "6.70" "3.60" "1" "cell-cell signaling;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12490, Pf21034" "54828" "ENSG00000141376" "BCAS3" "hsa:54828; Q17RM0; Q6KF21; Q8IXI6; Q8NDR8; Q8TDL9; Q8TDM1; Q8WY55; Q9BVF0; Q9H6U6; Q9H957; Q9H9Y9; Q9NXP4" "" "Ectoderm differentiation" "1" "0" "1.129" "0.992" "1.318" "1.207" "1.108" "1.225" "1.055" "1.082" "1.001" "85.9" "96.9" "85.2" "113.2" "103.7" "95.2" "105.2" "90.6" "92.9" "86.0" "" "" "" "" "" "" "" "" "" "" "77.5" "74.8" "65.9" "76.2" "86.5" "81.3" "89.3" "65.6" "62.7" "86.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585419871706527859" "False" "High" "IsMasterProtein" "Q8TDY2" "RB1-inducible coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=RB1CC1 PE=1 SV=3" "0.001" "False" "4.000" "1" "1" "1" "1" "1594" "183.0" "5.41" "2.94" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10377" "9821" "ENSG00000023287" "RB1CC1" "hsa:9821; Q86YR4; Q8TDY2; Q8WVU9; Q92601" "Macroautophagy" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4234172936871541887" "False" "High" "IsMasterProtein" "Q9HA65" "TBC1 domain family member 17 OS=Homo sapiens OX=9606 GN=TBC1D17 PE=1 SV=3" "0.001" "False" "3.993" "1" "1" "1" "1" "648" "72.6" "5.21" "2.95" "1" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00566, Pf12068" "79735" "ENSG00000104946" "TBC1D17" "B4DT12; B9A6L8; F5H1W7; hsa:79735; Q9HA65" "TBC/RABGAPs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293840026169595064" "False" "High" "IsMasterProtein" "Q6ZVK8" "8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens OX=9606 GN=NUDT18 PE=1 SV=3" "0.001" "False" "3.987" "3" "1" "1" "1" "323" "35.5" "6.23" "3.46" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00293" "79873" "ENSG00000275074" "NUDT18" "hsa:79873; Q6ZVK8; Q8IZ75; Q9H687" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485123881553311665" "False" "High" "IsMasterProtein" "Q8TEB1" "DDB1- and CUL4-associated factor 11 OS=Homo sapiens OX=9606 GN=DCAF11 PE=1 SV=1" "0.001" "False" "3.985" "2" "1" "1" "1" "546" "61.6" "6.40" "3.48" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80344" "ENSG00000100897; ENSG00000284796" "DCAF11" "B3KQ83; D3DS56; hsa:80344; Q5D039; Q86U00; Q86U39; Q8NDN2; Q8TEB1; Q9H2J0; Q9H3A3; Q9H5C9" "Neddylation" "Ciliary landscape" "2" "0" "1.008" "0.953" "1.083" "0.855" "0.953" "0.969" "0.976" "0.965" "0.967" "57.5" "58.0" "54.8" "62.3" "49.2" "54.8" "55.7" "56.1" "55.5" "55.6" "" "" "" "" "" "" "" "" "" "" "51.9" "44.7" "42.4" "42.0" "41.0" "46.8" "47.3" "40.6" "37.4" "55.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3013944943172909164" "False" "High" "IsMasterProtein" "A0MZ66" "Shootin-1 OS=Homo sapiens OX=9606 GN=SHTN1 PE=1 SV=4" "0.001" "False" "3.984" "4" "2" "2" "2" "631" "71.6" "5.33" "2.09" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "57698" "ENSG00000187164" "SHTN1" "A0MZ66; A8MYU7; B3KRD3; B3KRH2; B3KTE0; B3KTJ7; B3KTJ8; B4E3U1; B7Z7Z9; hsa:57698; Q68DG1; Q6PIM5; Q9HCH4; Q9NUV0" "Recycling pathway of L1" "" "1" "0" "0.789" "1.015" "1.229" "0.926" "0.968" "1.116" "0.835" "0.992" "1.991" "43.6" "34.4" "44.2" "53.6" "40.4" "42.2" "48.7" "36.4" "43.3" "86.8" "" "" "" "" "" "" "" "" "" "" "39.4" "26.5" "34.2" "36.1" "33.7" "36.0" "41.3" "26.4" "29.2" "86.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811963604537530771" "False" "High" "IsMasterProtein" "Q96S15" "GATOR2 complex protein WDR24 OS=Homo sapiens OX=9606 GN=WDR24 PE=1 SV=2" "0.001" "False" "3.981" "1" "1" "1" "1" "790" "88.2" "6.52" "3.39" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "84219" "ENSG00000127580" "WDR24" "A2IDB8; D3DU59; hsa:84219; Q96GC7; Q96S15; Q9H0B7" "Amino acids regulate mTORC1" "" "1" "0" "1.128" "1.114" "0.932" "0.955" "0.979" "1.056" "1.095" "1.030" "0.941" "90.8" "102.5" "101.2" "84.7" "86.8" "88.9" "95.9" "99.4" "93.6" "85.5" "" "" "" "" "" "" "" "" "" "" "82.0" "79.1" "78.2" "57.0" "72.4" "75.9" "81.4" "72.0" "63.1" "85.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370234138651289741" "False" "High" "IsMasterProtein" "Q96RS0" "Trimethylguanosine synthase OS=Homo sapiens OX=9606 GN=TGS1 PE=1 SV=3" "0.001" "False" "3.980" "3" "1" "1" "1" "853" "96.6" "4.94" "2.41" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09445" "96764" "ENSG00000137574" "TGS1" "A6NJQ5; hsa:96764; Q5GH23; Q8TDG9; Q96QU3; Q96RS0; Q9H5V3" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly" "" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "-1703927075416448593" "False" "High" "IsMasterProtein" "P07477" "Serine protease 1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1" "0.001" "False" "3.967" "8" "1" "2" "1" "247" "26.5" "6.51" "2.41" "1" "cell organization and biogenesis;protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "5644" "ENSG00000204983; ENSG00000274247" "PRSS1" "A1A509; A6NJ71; B2R5I5; hsa:5644; P07477; Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7" "Uptake of dietary cobalamins into enterocytes; Activation of Matrix Metalloproteinases" "" "2" "0" "0.941" "1.948" "1.110" "1.572" "1.387" "1.470" "1.309" "1.797" "0.756" "87.0" "81.9" "169.6" "96.6" "136.8" "120.7" "128.0" "113.9" "156.4" "65.8" "" "" "" "" "" "" "" "" "" "" "78.6" "63.1" "131.2" "65.0" "114.1" "103.0" "108.6" "82.4" "105.5" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3946386613732823747" "False" "High" "IsMasterProtein" "Q8WXD5" "Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1" "0.001" "False" "3.965" "6" "1" "2" "1" "167" "18.8" "5.12" "6.50" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06372, Pf20417" "79833" "ENSG00000152147" "GEMIN6" "B2RDP8; hsa:79833; Q53SI5; Q8WVB4; Q8WXD5; Q9H5G6" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "" "2" "0" "1.046" "0.872" "1.021" "0.899" "0.963" "0.935" "0.905" "0.927" "0.977" "139.3" "145.7" "121.5" "142.3" "125.2" "134.2" "130.3" "126.1" "129.2" "136.1" "" "" "" "" "" "" "" "" "" "" "125.8" "112.4" "94.0" "95.8" "104.5" "114.5" "110.5" "91.3" "87.1" "136.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739885640391199971" "False" "High" "IsMasterProtein" "Q8IY57" "YY1-associated factor 2 OS=Homo sapiens OX=9606 GN=YAF2 PE=1 SV=3" "0.001" "False" "3.964" "18" "2" "2" "1" "180" "19.9" "9.72" "5.85" "2" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "10138" "ENSG00000015153" "YAF2" "A8K5P0; B4DFU3; G3V465; hsa:10138; Q8IY57; Q99710" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "Not Found" "Not Found" "Not Found" "1" "" "-6620394605716673272" "False" "High" "IsMasterProtein" "Q96GX2" "Ataxin-7-like protein 3B OS=Homo sapiens OX=9606 GN=ATXN7L3B PE=1 SV=2" "0.001" "False" "3.961" "10" "1" "1" "1" "97" "10.8" "4.36" "2.92" "1" "other biological processes" "other cell component" "" "" "552889" "ENSG00000253719" "ATXN7L3B" "hsa:552889; Q96GX2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155365173843636052" "False" "High" "IsMasterProtein" "P48507" "Glutamate--cysteine ligase regulatory subunit OS=Homo sapiens OX=9606 GN=GCLM PE=1 SV=1" "0.001" "False" "3.953" "5" "1" "1" "1" "274" "30.7" "6.02" "2.57" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00248" "2730" "ENSG00000023909" "GCLM" "A8K334; D3DT45; hsa:2730; M5A959; P48507; Q6FHC1; Q9NPX9; Q9NU74" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "Glutathione metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; NRF2-ARE regulation; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311926917854502333" "False" "High" "IsMasterProtein" "O43414" "ERI1 exoribonuclease 3 OS=Homo sapiens OX=9606 GN=ERI3 PE=1 SV=2" "0.001" "False" "3.937" "6" "2" "2" "2" "337" "37.2" "8.07" "4.86" "2" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00929" "79033" "ENSG00000117419" "ERI3" "B1AK98; hsa:79033; O43414; Q5T2T7; Q5T2T9; Q5TG35; Q9BQA0; Q9UEB4" "" "" "0" "0" "1.039" "1.015" "1.316" "1.569" "1.214" "1.454" "0.927" "1.185" "1.025" "13.8" "14.4" "14.0" "18.2" "21.7" "16.8" "20.1" "12.8" "16.4" "14.2" "" "" "" "" "" "" "" "" "" "" "12.5" "11.1" "10.9" "12.3" "18.1" "14.3" "17.1" "9.3" "11.1" "14.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574893947770882391" "False" "High" "IsMasterProtein" "P53701" "Holocytochrome c-type synthase OS=Homo sapiens OX=9606 GN=HCCS PE=1 SV=1" "0.001" "False" "3.927" "4" "1" "1" "1" "268" "30.6" "6.68" "3.61" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf01265" "3052" "ENSG00000004961" "HCCS" "B3KUS1; hsa:3052; P53701; Q502X8" "" "" "0" "0" "0.810" "1.319" "1.271" "1.061" "1.463" "0.984" "1.147" "1.363" "0.741" "40.4" "32.7" "53.3" "51.3" "42.9" "59.1" "39.7" "46.3" "55.0" "29.9" "" "" "" "" "" "" "" "" "" "" "36.4" "25.2" "41.2" "34.5" "35.7" "50.4" "33.7" "33.5" "37.1" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5102394332226681343" "False" "High" "IsMasterProtein" "Q05932" "Folylpolyglutamate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=FPGS PE=1 SV=3" "0.001" "False" "3.927" "3" "2" "2" "2" "587" "64.6" "7.94" "3.70" "2" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "" "2356" "ENSG00000136877" "FPGS" "B3KPW4; B7Z2Z3; F5H0K6; hsa:2356; Q05932; Q5JU19; Q5JU22; Q6P2P6" "" "Fluoropyrimidine activity" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "531745898464633118" "False" "High" "IsMasterProtein" "Q6P3S6" "F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1" "0.001" "False" "3.920" "3" "2" "2" "2" "717" "77.8" "7.43" "5.89" "2" "" "other cell component" "other molecular function" "Pf12937, Pf13415, Pf13854" "54455" "ENSG00000037637; ENSG00000291375" "FBXO42" "B3KP30; hsa:54455; Q5TEU8; Q6P3S6; Q86XI0; Q8N3N4; Q8N5F8; Q9BRM0; Q9P2L4" "" "" "0" "0" "0.874" "0.753" "0.974" "0.868" "0.939" "0.878" "0.883" "0.885" "0.757" "69.6" "60.8" "52.4" "67.8" "60.4" "65.3" "61.1" "61.5" "61.6" "52.7" "" "" "" "" "" "" "" "" "" "" "62.8" "46.9" "40.5" "45.7" "50.4" "55.8" "51.9" "44.5" "41.6" "52.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7392710609967527407" "False" "High" "IsMasterProtein" "Q96BH1" "E3 ubiquitin-protein ligase RNF25 OS=Homo sapiens OX=9606 GN=RNF25 PE=1 SV=1" "0.001" "False" "3.913" "2" "1" "1" "1" "459" "51.2" "6.54" "3.42" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf05773, Pf13639" "64320" "ENSG00000163481" "RNF25" "A8K0D6; hsa:64320; Q53HQ5; Q96BH1; Q9H874" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.900" "0.869" "0.993" "0.850" "0.809" "0.944" "0.984" "0.758" "0.686" "112.9" "101.7" "98.2" "112.1" "96.0" "91.4" "106.6" "111.1" "85.6" "77.5" "" "" "" "" "" "" "" "" "" "" "101.9" "78.4" "75.9" "75.5" "80.1" "78.0" "90.4" "80.4" "57.7" "77.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6182568076537308589" "False" "High" "IsMasterProtein" "P35030" "Trypsin-3 OS=Homo sapiens OX=9606 GN=PRSS3 PE=1 SV=2" "0.001" "False" "3.909" "4" "1" "1" "1" "304" "32.5" "7.49" "2.54" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf00089" "5646" "ENSG00000010438" "PRSS3" "A8CED1; A8CED3; A9Z1Y4; E7ES07; F8W7P3; hsa:5646; P15951; P35030; Q15665; Q5VXV0; Q6ISJ4; Q9UQV3" "Neutrophil degranulation; Uptake of dietary cobalamins into enterocytes; Antimicrobial peptides; Alpha-defensins" "" "4" "0" "0.947" "3.149" "1.643" "1.848" "1.719" "2.993" "4.529" "0.762" "1.760" "7.9" "7.5" "24.9" "13.0" "14.6" "13.6" "23.7" "35.8" "6.0" "13.9" "" "" "" "" "" "" "" "" "" "" "7.1" "5.8" "19.3" "8.7" "12.2" "11.6" "20.1" "25.9" "4.1" "13.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396014057802155010" "False" "High" "IsMasterProtein" "Q15910" "Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens OX=9606 GN=EZH2 PE=1 SV=2" "0.001" "False" "3.904" "2" "2" "2" "2" "746" "85.3" "7.02" "4.88" "2" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf11616, Pf18118, Pf18264, Pf21358" "2146" "ENSG00000106462" "EZH2" "B2RAQ1; B3KS30; B7Z1D6; B7Z7L6; hsa:2146; Q15755; Q15910; Q75MG3; Q92857; Q96FI6" "Defective pyroptosis; HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "Cell differentiation - expanded index; Histone modifications; Endoderm differentiation; Interactome of polycomb repressive complex 2 (PRC2) ; MECP2 and associated Rett syndrome; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-511612548329445483" "False" "High" "IsMasterProtein" "P32970" "CD70 antigen OS=Homo sapiens OX=9606 GN=CD70 PE=1 SV=2" "0.001" "False" "3.902" "6" "1" "1" "1" "193" "21.1" "8.53" "3.52" "1" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf00229" "970" "ENSG00000125726" "CD70" "B4DPR8; hsa:970; P32970; Q53XX4; Q96J57" "TNFs bind their physiological receptors" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1333795596038477477" "False" "High" "IsMasterProtein" "P62877" "E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1" "0.001" "False" "3.883" "7" "1" "2" "1" "108" "12.3" "6.96" "5.72" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9978" "ENSG00000100387" "RBX1" "B2RDY1; hsa:9978; P62877; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Degradation of DVL; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Evasion by RSV of host interferon responses; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Regulation of BACH1 activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of TC-NER Pre-Incision Complex; Prolactin receptor signaling; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "Cell cycle; Dual hijack model of Vif in HIV infection; TGF-beta signaling pathway; Type 2 papillary renal cell carcinoma; NRF2-ARE regulation; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Nucleotide excision repair; Hijack of ubiquitination by SARS-CoV-2; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 1p36 copy number variation syndrome" "48" "0" "0.983" "0.846" "1.038" "0.936" "0.962" "0.876" "0.969" "0.963" "0.684" "143.9" "141.5" "121.8" "149.4" "134.7" "138.4" "126.1" "139.4" "138.6" "98.4" "" "" "" "" "" "" "" "" "" "" "129.9" "109.1" "94.2" "100.6" "112.4" "118.1" "107.0" "100.9" "93.5" "98.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331601319371966852" "False" "High" "IsMasterProtein" "P21964" "Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2" "0.001" "False" "3.883" "6" "2" "2" "2" "271" "30.0" "5.47" "5.12" "2" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01596" "1312" "ENSG00000093010" "COMT" "A8MPV9; hsa:1312; P21964; Q6IB07; Q6ICE6; Q9BWC7" "Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase" "Dopamine metabolism; Flavan-3-ol metabolic pathway; MTHFR deficiency; 22q11.2 copy number variation syndrome; Primary ovarian insufficiency; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974291959383986730" "False" "High" "IsMasterProtein" "Q9UL33" "Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1" "0.001" "False" "3.876" "12" "2" "2" "2" "140" "16.1" "6.77" "6.07" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04628" "51693" "ENSG00000167515" "TRAPPC2L" "B2R4M9; hsa:51693; Q6ZTA7; Q9NZZ4; Q9UL33" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.048" "1.057" "0.954" "1.095" "0.958" "1.020" "0.969" "1.101" "1.460" "173.9" "182.1" "183.8" "165.8" "190.4" "166.6" "177.4" "168.5" "191.3" "253.8" "" "" "" "" "" "" "" "" "" "" "156.9" "140.5" "142.1" "111.7" "158.8" "142.2" "150.5" "121.9" "129.1" "253.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-768881656379736442" "False" "High" "IsMasterProtein" "Q9BT73" "Proteasome assembly chaperone 3 OS=Homo sapiens OX=9606 GN=PSMG3 PE=1 SV=1" "0.001" "False" "3.872" "11" "1" "1" "1" "122" "13.1" "7.88" "2.98" "1" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf10178" "84262" "ENSG00000157778" "PSMG3" "A4D216; A8MPW2; hsa:84262; Q9BT73" "" "" "0" "0" "0.991" "0.824" "1.023" "1.156" "1.469" "1.154" "0.930" "0.618" "0.699" "25.1" "24.8" "20.6" "25.6" "29.0" "36.8" "28.9" "23.3" "15.5" "17.5" "" "" "" "" "" "" "" "" "" "" "22.6" "19.1" "16.0" "17.3" "24.2" "31.4" "24.5" "16.9" "10.4" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8105981666538771075" "False" "High" "IsMasterProtein" "P80297" "Metallothionein-1X OS=Homo sapiens OX=9606 GN=MT1X PE=1 SV=1" "0.001" "False" "3.871" "13" "1" "1" "1" "61" "6.1" "7.96" "3.81" "1" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "4501" "ENSG00000187193" "MT1X" "A8MUC7; hsa:4501; P80297" "Metallothioneins bind metals" "Copper homeostasis; Zinc homeostasis; Oxidative stress response" "4" "0" "0.849" "1.075" "0.996" "0.723" "1.018" "0.843" "0.912" "1.045" "0.628" "182.8" "155.2" "196.4" "182.0" "132.0" "186.1" "154.0" "166.6" "190.9" "114.8" "" "" "" "" "" "" "" "" "" "" "165.0" "119.7" "151.9" "122.5" "110.2" "158.8" "130.7" "120.6" "128.8" "114.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7850572796846009162" "False" "High" "IsMasterProtein" "P52435" "DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1" "0.001" "False" "3.869" "9" "1" "1" "1" "117" "13.3" "5.86" "2.96" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "5439" "ENSG00000005075" "POLR2J" "A5D6V8; hsa:5439; O43375; P52435" "TP53 Regulates Transcription of DNA Repair Genes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation" "43" "0" "1.046" "0.975" "1.258" "1.048" "1.097" "1.016" "1.198" "0.966" "1.088" "37.6" "39.3" "36.6" "47.3" "39.4" "41.2" "38.2" "45.0" "36.3" "40.9" "" "" "" "" "" "" "" "" "" "" "33.9" "30.3" "28.3" "31.8" "32.8" "35.2" "32.4" "32.6" "24.5" "40.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5644554619979627576" "False" "High" "IsMasterProtein" "O75251" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3" "0.001" "False" "3.868" "8" "2" "2" "2" "213" "23.5" "9.99" "5.38" "2" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01058" "374291" "ENSG00000115286" "NDUFS7" "B3KRI2; hsa:374291; O75251; Q2T9H7; Q9BV17" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "0.955" "0.874" "1.046" "0.982" "1.262" "0.815" "0.845" "1.151" "0.695" "202.3" "193.1" "176.8" "211.6" "198.7" "255.2" "164.9" "170.9" "232.8" "140.6" "" "" "" "" "" "" "" "" "" "" "182.6" "149.0" "136.7" "142.5" "165.8" "217.9" "139.9" "123.7" "157.0" "140.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1798322026652807896" "False" "High" "IsMasterProtein" "Q5VTU8" "ATP synthase subunit epsilon-like protein, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1EP2 PE=1 SV=1" "0.001" "False" "3.867" "29" "2" "3" "2" "51" "5.8" "10.14" "8.80" "2" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "" "" "ATP5F1EP2" "Q5VTU8" "" "" "0" "0" "0.942" "1.157" "0.805" "0.986" "1.244" "1.028" "1.201" "1.141" "0.653" "220.7" "207.9" "255.3" "177.7" "217.6" "274.5" "226.9" "265.1" "251.7" "144.1" "" "" "" "" "" "" "" "" "" "" "199.2" "160.4" "197.4" "119.7" "181.5" "234.3" "192.5" "191.9" "169.8" "144.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5516289566189376071" "False" "High" "IsMasterProtein" "Q13084" "Large ribosomal subunit protein bL28m OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4" "0.001" "False" "3.864" "4" "1" "1" "1" "256" "30.1" "8.29" "3.13" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00830" "10573" "ENSG00000086504" "MRPL28" "B2RCM4; D3DU46; hsa:10573; Q13084; Q4TT39; Q96S26; Q9BQD8; Q9BR04" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821127370945399140" "False" "High" "IsMasterProtein" "Q5JVF3" "PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2" "0.001" "False" "3.849" "2" "1" "1" "1" "399" "46.0" "8.53" "3.33" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01399" "55795" "ENSG00000126226" "PCID2" "A6NK09; hsa:55795; Q3ZCX1; Q5JVF3; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3" "" "" "0" "0" "0.953" "1.312" "0.914" "1.072" "1.092" "0.995" "0.858" "1.285" "6.363" "59.6" "56.8" "78.2" "54.5" "63.8" "65.1" "59.3" "51.1" "76.6" "379.0" "" "" "" "" "" "" "" "" "" "" "53.8" "43.8" "60.4" "36.7" "53.3" "55.5" "50.3" "37.0" "51.6" "379.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6709781459489319409" "False" "High" "IsMasterProtein" "Q9UHN1" "DNA polymerase subunit gamma-2 OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1" "0.001" "False" "3.849" "2" "1" "1" "1" "485" "54.9" "8.35" "3.26" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf03129" "11232" "ENSG00000256525" "POLG2" "hsa:11232; O00419; Q0IJ81; Q96GW2; Q9UHN1; Q9UK35; Q9UK94" "Transcriptional activation of mitochondrial biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-296072814185556824" "False" "High" "IsMasterProtein" "Q9BUI4" "DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1" "0.001" "False" "3.846" "3" "2" "2" "2" "534" "60.6" "7.31" "5.32" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05645, Pf08221, Pf20912" "10623" "ENSG00000186141" "POLR3C" "hsa:10623; O15317; Q9BUI4; Q9Y3R6" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "10" "0" "1.080" "1.022" "1.206" "1.140" "1.138" "1.154" "0.967" "0.962" "1.514" "53.6" "57.9" "54.8" "64.7" "61.1" "61.0" "61.9" "51.9" "51.6" "81.2" "" "" "" "" "" "" "" "" "" "" "48.4" "44.7" "42.4" "43.6" "51.0" "52.1" "52.5" "37.5" "34.8" "81.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3294406842495901290" "False" "High" "IsMasterProtein" "Q8NHM5" "Lysine-specific demethylase 2B OS=Homo sapiens OX=9606 GN=KDM2B PE=1 SV=1" "0.001" "False" "3.839" "1" "1" "1" "1" "1336" "152.5" "8.56" "2.59" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02008, Pf12937, Pf13621, Pf16866, Pf17811" "84678" "ENSG00000089094" "KDM2B" "A8MRS1; hsa:84678; Q1RLM7; Q8NCI2; Q8NHM5; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75" "HDMs demethylate histones" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "2" "0" "0.899" "0.830" "1.145" "1.040" "0.848" "1.104" "0.848" "0.928" "4.206" "28.5" "25.6" "23.6" "32.6" "29.6" "24.2" "31.5" "24.2" "26.4" "119.8" "" "" "" "" "" "" "" "" "" "" "25.7" "19.7" "18.3" "22.0" "24.7" "20.6" "26.7" "17.5" "17.8" "119.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494838164348438910" "False" "High" "IsMasterProtein" "Q08117" "TLE family member 5 OS=Homo sapiens OX=9606 GN=TLE5 PE=1 SV=4" "0.001" "False" "3.830" "5" "1" "1" "1" "197" "22.0" "6.37" "3.24" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf03920" "166" "ENSG00000104964" "TLE5" "B2RBL0; hsa:166; Q08117; Q12808; Q14CJ1; Q96TG9; Q9UDY9" "Repression of WNT target genes" "Androgen receptor signaling pathway; Ectoderm differentiation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-398928808883879512" "False" "High" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "0.001" "False" "3.829" "14" "2" "2" "2" "99" "11.3" "9.31" "5.27" "2" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "0.991" "1.034" "0.858" "0.940" "0.984" "1.130" "1.001" "0.930" "0.729" "176.6" "174.9" "182.5" "151.5" "165.9" "173.6" "199.4" "176.7" "164.1" "128.7" "" "" "" "" "" "" "" "" "" "" "159.4" "134.9" "141.2" "102.0" "138.4" "148.2" "169.2" "127.9" "110.7" "128.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952691654267697192" "False" "High" "IsMasterProtein" "Q15067" "Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3" "0.001" "False" "3.823" "1" "1" "1" "1" "660" "74.4" "8.16" "2.83" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770, Pf14749" "51" "ENSG00000161533" "ACOX1" "A8K6X8; A8KAA0; B4DK61; F5GYQ8; hsa:51; Q12863; Q15067; Q15068; Q15101; Q16131; Q7Z3W5; Q9UD31" "TYSND1 cleaves peroxisomal proteins" "Estrogen receptor pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643527966773386320" "False" "High" "IsMasterProtein" "Q8IWZ8" "SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2" "0.001" "False" "3.798" "3" "2" "2" "2" "645" "72.4" "7.61" "5.76" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "57794" "ENSG00000105705" "SUGP1" "hsa:57794; O60378; Q6P3X9; Q8IWZ8; Q8TCQ4; Q8WWT4; Q8WWT5; Q9NTG3" "mRNA Splicing - Major Pathway" "mRNA processing" "2" "0" "1.068" "1.386" "1.223" "0.997" "1.383" "1.100" "1.172" "1.389" "1.941" "140.8" "150.3" "195.2" "172.2" "140.4" "194.8" "154.9" "164.9" "195.5" "273.3" "" "" "" "" "" "" "" "" "" "" "127.1" "116.0" "151.0" "115.9" "117.1" "166.2" "131.4" "119.4" "131.9" "273.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-998134309870178967" "False" "High" "IsMasterProtein" "P47974" "mRNA decay activator protein ZFP36L2 OS=Homo sapiens OX=9606 GN=ZFP36L2 PE=1 SV=3" "0.001" "False" "3.792" "3" "1" "1" "1" "494" "51.0" "8.16" "3.87" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "678" "ENSG00000152518" "ZFP36L2" "hsa:678; P47974; Q53TB4; Q9BSJ3" "M-decay: degradation of maternal mRNAs by maternally stored factors" "Pre-implantation embryo; TYROBP causal network in microglia" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036187621347807091" "False" "High" "IsMasterProtein" "P23469" "Receptor-type tyrosine-protein phosphatase epsilon OS=Homo sapiens OX=9606 GN=PTPRE PE=1 SV=1" "0.001" "False" "3.789" "1" "1" "1" "1" "700" "80.6" "7.02" "3.35" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00102" "5791" "ENSG00000132334" "PTPRE" "hsa:5791; P23469; Q13345; Q5VWH3; Q5VWH4; Q96KQ6" "" "" "0" "0" "1.230" "1.348" "1.586" "1.268" "1.227" "1.311" "1.038" "1.417" "7.611" "26.7" "32.9" "36.0" "42.4" "33.9" "32.8" "35.0" "27.7" "37.9" "203.4" "" "" "" "" "" "" "" "" "" "" "24.1" "25.3" "27.9" "28.5" "28.3" "28.0" "29.7" "20.1" "25.5" "203.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "334815564542611035" "False" "High" "IsMasterProtein" "Q9BTF0" "THUMP domain-containing protein 2 OS=Homo sapiens OX=9606 GN=THUMPD2 PE=1 SV=2" "0.001" "False" "3.785" "4" "2" "2" "2" "503" "56.4" "7.81" "6.02" "2" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "80745" "ENSG00000138050" "THUMPD2" "A8K7I7; hsa:80745; Q53TT8; Q53TV0; Q9BTF0" "" "" "0" "0" "1.273" "1.107" "1.201" "1.295" "1.161" "1.194" "1.103" "1.206" "0.974" "109.2" "139.0" "120.8" "131.1" "141.4" "126.8" "130.4" "120.4" "131.7" "106.3" "" "" "" "" "" "" "" "" "" "" "98.6" "107.2" "93.4" "88.3" "117.9" "108.2" "110.6" "87.2" "88.8" "106.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5046269974375817075" "False" "High" "IsMasterProtein" "Q8TAC2" "Josephin-2 OS=Homo sapiens OX=9606 GN=JOSD2 PE=1 SV=1" "0.001" "False" "3.782" "6" "1" "1" "1" "188" "20.7" "7.42" "3.42" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf02099" "126119" "ENSG00000161677" "JOSD2" "hsa:126119; M0QX25; Q8TAC2" "Josephin domain DUBs" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9192957103143993371" "False" "High" "IsMasterProtein" "Cont_Q9TTE1" "Serpin A3-1 OS=Bos taurus OX=9913 GN=SERPINA3-1 PE=1 SV=3" "0.001" "True" "3.781" "2" "1" "1" "1" "411" "46.2" "5.99" "3.36" "1" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "286804" "" "SERPINA3-1" "bta:286804; Q2KIQ9; Q3ZEJ7; Q9TTE1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3157784244312675539" "False" "High" "IsMasterProtein" "Q9UKD2" "mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2" "0.001" "False" "3.777" "5" "1" "1" "1" "239" "27.5" "8.29" "3.45" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00466, Pf17777" "51154" "ENSG00000053372" "MRTO4" "B3KNB3; hsa:51154; Q5TG55; Q96SS6; Q9BPV9; Q9UKD2" "" "" "0" "0" "0.913" "0.986" "1.183" "1.057" "1.046" "1.078" "1.054" "1.179" "0.567" "82.2" "75.0" "81.0" "97.2" "86.9" "85.9" "88.6" "86.6" "96.9" "46.6" "" "" "" "" "" "" "" "" "" "" "74.2" "57.9" "62.7" "65.5" "72.5" "73.4" "75.2" "62.7" "65.4" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493401864324206702" "False" "High" "IsMasterProtein" "Q53S33" "BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1" "0.001" "False" "3.776" "13" "2" "2" "2" "107" "12.1" "9.64" "5.66" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf01722" "388962" "ENSG00000163170" "BOLA3" "G3XAB0; hsa:388962; Q53S33" "" "" "0" "0" "0.958" "0.984" "0.906" "0.876" "0.876" "1.026" "0.928" "0.991" "0.782" "124.0" "118.8" "122.0" "112.4" "108.6" "108.6" "127.2" "115.0" "122.9" "96.9" "" "" "" "" "" "" "" "" "" "" "111.9" "91.6" "94.4" "75.7" "90.5" "92.7" "107.9" "83.3" "82.9" "96.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213215215106064220" "False" "High" "IsMasterProtein" "Q8WZ82" "Esterase OVCA2 OS=Homo sapiens OX=9606 GN=OVCA2 PE=1 SV=1" "0.001" "False" "3.775" "6" "1" "1" "1" "227" "24.4" "6.89" "2.72" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf03959" "124641" "ENSG00000262664" "OVCA2" "hsa:124641; Q86XN3; Q8IW87; Q8WZ82; Q9UCX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1999120718507000118" "False" "High" "IsMasterProtein" "P17707" "S-adenosylmethionine decarboxylase proenzyme OS=Homo sapiens OX=9606 GN=AMD1 PE=1 SV=2" "0.001" "False" "3.764" "4" "1" "1" "1" "334" "38.3" "6.00" "3.26" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf01536" "262" "ENSG00000123505" "AMD1" "E1P5F7; hsa:262; P17707; Q5VXN4; Q5VXN6; Q9BWK4" "Metabolism of polyamines" "Methionine de novo and salvage pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93736052394886069" "False" "High" "IsMasterProtein" "P50583" "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3" "0.001" "False" "3.762" "10" "2" "2" "2" "147" "16.8" "5.35" "5.41" "2" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00293" "318" "ENSG00000164978" "NUDT2" "D3DRM0; hsa:318; P50583; Q5T589" "Detoxification of Reactive Oxygen Species" "" "1" "0" "0.926" "0.774" "1.133" "1.009" "0.950" "0.908" "0.899" "0.952" "1.016" "160.3" "148.5" "124.1" "181.7" "161.7" "152.4" "145.6" "144.2" "152.6" "162.8" "" "" "" "" "" "" "" "" "" "" "144.7" "114.5" "96.0" "122.4" "134.9" "130.0" "123.5" "104.3" "102.9" "162.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5846443296709188562" "False" "High" "IsMasterProtein" "Q9Y248" "DNA replication complex GINS protein PSF2 OS=Homo sapiens OX=9606 GN=GINS2 PE=1 SV=1" "0.001" "False" "3.758" "8" "1" "1" "1" "185" "21.4" "5.44" "2.59" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus" "" "Pf05916" "51659" "ENSG00000131153" "GINS2" "D3DUM5; hsa:51659; Q6IAG9; Q9Y248" "Unwinding of DNA" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "High" "High" "High" "Not Found" "Not Found" "High" "1" "" "1790933947294059226" "False" "High" "IsMasterProtein" "Q9H477" "Ribokinase OS=Homo sapiens OX=9606 GN=RBKS PE=1 SV=1" "0.001" "False" "3.756" "3" "1" "1" "1" "322" "34.1" "5.05" "2.76" "1" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "64080" "ENSG00000171174" "RBKS" "A9UK04; B4DV96; hsa:64080; Q9H477" "Pentose phosphate pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7883409800749118824" "False" "High" "IsMasterProtein" "Q7KZ85" "Transcription elongation factor SPT6 OS=Homo sapiens OX=9606 GN=SUPT6H PE=1 SV=2" "0.001" "False" "3.750" "1" "2" "2" "2" "1726" "198.9" "4.91" "4.14" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00575, Pf14632, Pf14633, Pf14635, Pf14639, Pf14641, Pf17674" "6830" "ENSG00000109111" "SUPT6H" "A7E2B4; hsa:6830; Q15737; Q6GMQ4; Q7KYW9; Q7KZ85; Q7LDK4; Q8N526; Q92775; Q96AH3; Q9BTH9; Q9BTI2" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283979429673317137" "False" "High" "IsMasterProtein" "A6NIH7" "Protein unc-119 homolog B OS=Homo sapiens OX=9606 GN=UNC119B PE=1 SV=1" "0.001" "False" "3.737" "7" "2" "3" "1" "251" "28.1" "5.68" "6.92" "2" "cell organization and biogenesis;transport;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05351" "84747" "ENSG00000175970" "UNC119B" "A6NIH7; hsa:84747" "Trafficking of myristoylated proteins to the cilium" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-626678755710490294" "False" "High" "IsMasterProtein" "O14593" "DNA-binding protein RFXANK OS=Homo sapiens OX=9606 GN=RFXANK PE=1 SV=2" "0.001" "False" "3.735" "4" "1" "1" "1" "260" "28.1" "4.55" "3.14" "1" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023" "8625" "ENSG00000064490" "RFXANK" "hsa:8625; O14593; O95839; Q24JQ1; Q6FGA8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2639950246168757671" "False" "High" "IsMasterProtein" "P16591" "Tyrosine-protein kinase Fer OS=Homo sapiens OX=9606 GN=FER PE=1 SV=2" "0.001" "False" "3.735" "2" "2" "2" "2" "822" "94.6" "7.14" "3.89" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf00611, Pf07714" "2241" "ENSG00000151422" "FER" "B2RCR4; B4DSQ2; H2FLB8; hsa:2241; P16591" "Signaling by SCF-KIT" "" "1" "0" "1.288" "1.088" "1.315" "1.145" "1.388" "0.888" "1.025" "1.469" "2.871" "22.5" "29.0" "24.5" "29.6" "25.8" "31.2" "20.0" "23.1" "33.1" "64.6" "" "" "" "" "" "" "" "" "" "" "20.3" "22.4" "18.9" "19.9" "21.5" "26.7" "17.0" "16.7" "22.3" "64.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2425076065007408183" "False" "High" "IsMasterProtein" "Q9H7F0" "Polyamine-transporting ATPase 13A3 OS=Homo sapiens OX=9606 GN=ATP13A3 PE=1 SV=4" "0.001" "False" "3.722" "1" "1" "1" "1" "1226" "138.0" "6.64" "2.82" "1" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf00122, Pf00690, Pf12409, Pf13246" "79572" "ENSG00000133657" "ATP13A3" "hsa:79572; Q8NC11; Q96KS1; Q9H7F0" "" "" "0" "0" "1.344" "1.283" "1.195" "1.140" "1.273" "1.285" "1.153" "1.464" "1.221" "42.6" "57.3" "54.7" "50.9" "48.6" "54.2" "54.8" "49.1" "62.4" "52.0" "" "" "" "" "" "" "" "" "" "" "38.5" "44.2" "42.3" "34.3" "40.5" "46.3" "46.5" "35.5" "42.1" "52.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4664258247594329003" "False" "High" "IsMasterProtein" "Q9H9B1" "Histone-lysine N-methyltransferase EHMT1 OS=Homo sapiens OX=9606 GN=EHMT1 PE=1 SV=4" "0.001" "False" "3.718" "2" "2" "2" "2" "1298" "141.4" "5.76" "5.06" "2" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf05033, Pf12796, Pf21533" "79813" "ENSG00000181090" "EHMT1" "B1AQ58; B1AQ59; hsa:79813; Q86X08; Q8TCN7; Q96F53; Q96JF1; Q96KH4; Q9H9B1" "Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by E2F6; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines" "Histone modifications; MTHFR deficiency; Kleefstra syndrome" "8" "0" "1.433" "2.035" "1.709" "1.644" "1.609" "1.358" "1.242" "1.999" "2.117" "24.3" "34.9" "49.5" "41.6" "40.0" "39.2" "33.1" "30.2" "48.6" "51.5" "" "" "" "" "" "" "" "" "" "" "22.0" "26.9" "38.3" "28.0" "33.4" "33.4" "28.0" "21.9" "32.8" "51.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5299456138050834551" "False" "High" "IsMasterProtein" "O00115" "Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2" "0.001" "False" "3.717" "3" "1" "1" "1" "360" "39.6" "8.05" "3.40" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf03265" "1777" "ENSG00000105612" "DNASE2" "B2RD06; B7Z4K6; hsa:1777; O00115; O43910" "Lysosome Vesicle Biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3344145202623347770" "False" "High" "IsMasterProtein" "O60637" "Tetraspanin-3 OS=Homo sapiens OX=9606 GN=TSPAN3 PE=1 SV=1" "0.001" "False" "3.713" "6" "2" "4" "2" "253" "28.0" "5.81" "8.82" "2" "" "other membranes" "" "Pf00335" "10099" "ENSG00000140391" "TSPAN3" "A6NEH4; B3KQQ2; B4DP19; hsa:10099; O60637; Q9BW22; Q9NVX9" "" "" "0" "0" "0.966" "1.095" "1.133" "0.985" "1.079" "1.062" "1.121" "1.116" "0.682" "335.8" "324.4" "367.5" "380.6" "330.6" "362.4" "356.6" "376.3" "374.7" "229.1" "" "" "" "" "" "" "" "" "" "" "303.1" "250.3" "284.3" "256.3" "275.8" "309.3" "302.5" "272.3" "252.7" "229.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3382226448836069029" "False" "High" "IsMasterProtein" "Q69YH5" "Cell division cycle-associated protein 2 OS=Homo sapiens OX=9606 GN=CDCA2 PE=1 SV=2" "0.001" "False" "3.708" "1" "1" "1" "1" "1023" "112.6" "8.40" "2.51" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15276" "157313" "ENSG00000184661" "CDCA2" "hsa:157313; Q3SX74; Q4G0W0; Q5RKN0; Q69YH5; Q69YI4; Q6P464; Q8N7C1" "" "" "0" "0" "0.962" "1.312" "1.137" "1.225" "1.364" "1.122" "1.041" "1.251" "1.653" "73.7" "70.9" "96.7" "83.8" "90.3" "100.5" "82.6" "76.7" "92.2" "121.8" "" "" "" "" "" "" "" "" "" "" "66.5" "54.7" "74.8" "56.4" "75.3" "85.8" "70.1" "55.5" "62.2" "121.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1768337099241243287" "False" "High" "IsMasterProtein" "Q08ET2" "Sialic acid-binding Ig-like lectin 14 OS=Homo sapiens OX=9606 GN=SIGLEC14 PE=1 SV=1" "0.001" "False" "3.708" "7" "2" "2" "2" "396" "43.9" "7.96" "5.62" "2" "cell adhesion" "plasma membrane;other membranes" "other molecular function" "Pf07686, Pf08205, Pf13895" "100049587" "ENSG00000254415" "SIGLEC14" "hsa:100049587; Q08ET2; Q6UXG0" "Neutrophil degranulation; DAP12 interactions" "" "2" "0" "0.928" "0.975" "0.959" "0.990" "1.011" "0.988" "0.961" "1.050" "0.800" "275.4" "255.5" "268.4" "264.1" "272.6" "278.3" "272.1" "264.7" "289.2" "220.3" "" "" "" "" "" "" "" "" "" "" "248.6" "197.1" "207.6" "177.9" "227.4" "237.5" "230.8" "191.5" "195.1" "220.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5083710564544014092" "False" "High" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "0.001" "False" "3.694" "13" "2" "2" "1" "164" "19.3" "11.65" "4.70" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "mRNA processing" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3106213779201821222" "False" "High" "IsMasterProtein" "Q8N357" "Solute carrier family 35 member F6 OS=Homo sapiens OX=9606 GN=SLC35F6 PE=1 SV=1" "0.001" "False" "3.692" "3" "1" "1" "1" "371" "40.2" "6.93" "3.74" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf06027" "54978" "ENSG00000213699" "SLC35F6" "D6W543; hsa:54978; Q53GK2; Q8N357; Q8NBX6; Q9NWX0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6226496010076291767" "False" "High" "IsMasterProtein" "O60669" "Monocarboxylate transporter 2 OS=Homo sapiens OX=9606 GN=SLC16A7 PE=1 SV=2" "0.001" "False" "3.687" "2" "1" "1" "1" "478" "52.2" "9.31" "2.67" "1" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "transporter activity;other molecular function" "" "9194" "ENSG00000118596" "SLC16A7" "hsa:9194; O60669; Q8NEM3; Q9UPB3" "Proton-coupled monocarboxylate transport" "Male infertility" "2" "0" "1.161" "1.406" "0.981" "0.918" "0.938" "0.975" "0.982" "0.849" "0.836" "52.4" "60.8" "73.7" "51.4" "48.1" "49.1" "51.1" "51.5" "44.5" "43.8" "" "" "" "" "" "" "" "" "" "" "47.3" "46.9" "57.0" "34.6" "40.1" "41.9" "43.3" "37.2" "30.0" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5454865549219062540" "False" "High" "IsMasterProtein" "P14859" "POU domain, class 2, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU2F1 PE=1 SV=2" "0.001" "False" "3.682" "3" "1" "1" "1" "743" "76.4" "6.81" "3.34" "1" "other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157, Pf19536" "5451" "ENSG00000143190" "POU2F1" "B1AL91; B1AL93; B4E029; hsa:5451; J3KP77; P14859; Q5TBT7; Q6PK46; Q8NEU9; Q9BPV1" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling" "Integrated cancer pathway" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-829436805144986471" "False" "High" "IsMasterProtein" "P61927" "Large ribosomal subunit protein eL37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2" "0.001" "False" "3.679" "16" "2" "3" "2" "97" "11.1" "11.74" "8.20" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01907" "6167" "ENSG00000145592" "RPL37" "B2R4H2; hsa:6167; P02403; P61927; Q6IBB4; Q99883" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "Cytoplasmic ribosomal proteins" "14" "0" "0.851" "1.164" "0.917" "0.915" "0.843" "0.951" "1.077" "1.023" "0.401" "510.2" "434.2" "594.0" "467.8" "467.0" "430.1" "485.3" "549.3" "521.7" "204.6" "" "" "" "" "" "" "" "" "" "" "460.5" "334.9" "459.4" "315.0" "389.6" "367.1" "411.6" "397.5" "351.9" "204.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635059186967103870" "False" "High" "IsMasterProtein" "Q96PC3" "AP-1 complex subunit sigma-3 OS=Homo sapiens OX=9606 GN=AP1S3 PE=1 SV=1" "0.001" "False" "3.679" "10" "2" "2" "1" "154" "18.3" "6.79" "5.24" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "130340" "ENSG00000152056" "AP1S3" "B4DQZ1; hsa:130340; Q8WTY1; Q96DD1; Q96PC3" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3949732143901396407" "False" "High" "IsMasterProtein" "O43427" "Acidic fibroblast growth factor intracellular-binding protein OS=Homo sapiens OX=9606 GN=FIBP PE=1 SV=3" "0.001" "False" "3.670" "3" "1" "1" "1" "364" "41.9" "6.48" "2.59" "1" "signal transduction" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05427" "9158" "ENSG00000172500" "FIBP" "A8K0J7; hsa:9158; O43427; Q27Q85; Q6IBQ3; Q9HD65" "" "Modulators of TCR signaling and T cell activation" "1" "0" "1.422" "1.462" "1.453" "0.946" "1.293" "1.365" "1.335" "1.336" "1.617" "14.5" "20.6" "21.2" "21.0" "13.7" "18.7" "19.8" "19.3" "19.3" "23.4" "" "" "" "" "" "" "" "" "" "" "13.1" "15.9" "16.4" "14.2" "11.4" "16.0" "16.8" "14.0" "13.0" "23.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6809936595777039335" "False" "High" "IsMasterProtein" "Q69YN4" "Protein virilizer homolog OS=Homo sapiens OX=9606 GN=VIRMA PE=1 SV=2" "0.001" "False" "3.664" "0" "1" "1" "1" "1812" "201.9" "5.01" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15912" "25962" "ENSG00000164944" "VIRMA" "hsa:25962; Q2M1N0; Q69YN4; Q6AHX9; Q6NT78; Q7Z6C7; Q8IXH4; Q9BTH4; Q9H9C9; Q9NWR3; Q9P2B8; Q9UFW1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099504193891774007" "False" "High" "IsMasterProtein" "Q13557" "Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3" "0.001" "False" "3.659" "2" "1" "1" "1" "499" "56.3" "7.25" "3.21" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08332" "817" "ENSG00000145349" "CAMK2D" "A8MVS8; hsa:817; Q13557; Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9" "Signaling by BRAF and RAF1 fusions; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; SRF and miRs in smooth muscle differentiation and proliferation; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; ErbB signaling pathway" "33" "0" "0.869" "0.906" "0.848" "1.094" "0.808" "0.958" "0.869" "0.720" "1.408" "104.2" "90.6" "94.4" "88.3" "114.0" "84.2" "99.8" "90.5" "75.0" "146.7" "" "" "" "" "" "" "" "" "" "" "94.1" "69.9" "73.0" "59.5" "95.1" "71.9" "84.7" "65.5" "50.6" "146.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012915059673315434" "False" "High" "IsMasterProtein" "Q9UBK8" "Methionine synthase reductase OS=Homo sapiens OX=9606 GN=MTRR PE=1 SV=4" "0.001" "False" "3.651" "2" "2" "2" "2" "698" "77.6" "6.49" "5.06" "2" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00175, Pf00258, Pf00667" "4552" "ENSG00000124275" "MTRR" "hsa:4552; O60471; Q32MA9; Q7Z4M8; Q9UBK8" "Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Male infertility; Spina bifida" "10" "0" "0.966" "1.111" "1.168" "1.242" "1.137" "1.002" "1.028" "1.177" "1.709" "144.4" "139.5" "160.4" "168.6" "179.4" "164.2" "144.7" "148.4" "170.0" "246.8" "" "" "" "" "" "" "" "" "" "" "130.4" "107.6" "124.0" "113.5" "149.7" "140.1" "122.7" "107.4" "114.7" "246.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4925362542189153162" "False" "High" "IsMasterProtein" "Q92854" "Semaphorin-4D OS=Homo sapiens OX=9606 GN=SEMA4D PE=1 SV=1" "0.001" "False" "3.649" "1" "1" "1" "1" "862" "96.1" "7.96" "3.63" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00047, Pf01403, Pf01437" "10507" "ENSG00000187764" "SEMA4D" "B2RPM6; hsa:10507; Q7Z5S4; Q8N8B0; Q92854" "Sema4D induced cell migration and growth-cone collapse; Sema4D mediated inhibition of cell attachment and migration; Other semaphorin interactions" "Clock-controlled autophagy in bone metabolism" "4" "0" "1.050" "0.662" "1.143" "1.179" "0.796" "1.099" "1.102" "0.890" "0.600" "41.7" "43.8" "27.6" "47.7" "49.2" "33.2" "45.9" "46.0" "37.1" "25.0" "" "" "" "" "" "" "" "" "" "" "37.7" "33.8" "21.3" "32.1" "41.0" "28.4" "38.9" "33.3" "25.1" "25.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7964397888877464485" "False" "High" "IsMasterProtein" "P50897" "Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1" "0.001" "False" "3.641" "5" "2" "2" "2" "306" "34.2" "6.52" "4.12" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02089" "5538" "ENSG00000131238" "PPT1" "B4DY24; hsa:5538; P50897; Q6FGQ4" "Fatty acyl-CoA biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2039087024744643374" "False" "High" "IsMasterProtein" "Cont_Q5D862" "Filaggrin-2 OS=Homo sapiens OX=9606 GN=FLG2 PE=1 SV=1" "0.001" "True" "3.641" "3" "1" "1" "1" "2391" "247.9" "8.31" "2.68" "1" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other cell component" "other molecular function" "Pf01023" "388698" "ENSG00000143520" "FLG2" "hsa:388698; Q5D862; Q9H4U1" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488452650529328010" "False" "High" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=2" "0.001" "False" "3.639" "1" "1" "1" "1" "832" "94.3" "6.70" "2.75" "1" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04100, Pf16854" "55275" "ENSG00000141252; ENSG00000283883" "VPS53" "A8K2S8; B3FH42; hsa:55275; Q5VIR6; Q8WYW3; Q9BRR2; Q9BY02; Q9NV25" "Retrograde transport at the Trans-Golgi-Network" "" "1" "0" "0.986" "1.218" "1.236" "1.212" "0.909" "1.093" "0.850" "0.785" "3.212" "22.5" "22.2" "27.4" "27.8" "27.2" "20.4" "24.6" "19.1" "17.6" "72.2" "" "" "" "" "" "" "" "" "" "" "20.3" "17.1" "21.2" "18.7" "22.7" "17.4" "20.8" "13.8" "11.9" "72.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853605967738796226" "False" "High" "IsMasterProtein" "Q13137" "Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1" "0.001" "False" "3.631" "2" "1" "1" "1" "446" "52.2" "5.02" "3.32" "1" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17751" "10241" "ENSG00000136436" "CALCOCO2" "B2RBT0; B4DDC4; B4DDT4; B4DP36; B4E0C0; E7ENK0; E7ETP5; E9PBE5; hsa:10241; Q13137; Q53FQ5; Q53HB5; Q6IBN9; Q9BTF7" "" "" "0" "0" "0.976" "0.846" "1.038" "1.033" "0.787" "0.877" "0.851" "0.851" "1.145" "84.1" "82.1" "71.1" "87.2" "86.9" "66.2" "73.7" "71.5" "71.5" "96.2" "" "" "" "" "" "" "" "" "" "" "75.9" "63.3" "55.0" "58.8" "72.5" "56.5" "62.5" "51.8" "48.3" "96.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7938684201688622214" "False" "High" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "0.001" "False" "3.624" "10" "1" "1" "1" "275" "29.7" "6.80" "2.71" "1" "transport" "other membranes;cytosol" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "Cargo recognition for clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "High" "High" "High" "1" "" "5818593354028515611" "False" "High" "IsMasterProtein" "P56524" "Histone deacetylase 4 OS=Homo sapiens OX=9606 GN=HDAC4 PE=1 SV=3" "0.001" "False" "3.623" "2" "2" "2" "2" "1084" "119.0" "6.96" "5.24" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "9759" "ENSG00000068024" "HDAC4" "E9PGB9; F5GX36; hsa:9759; P56524; Q86YH7; Q9UND6" "SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of intracellular receptors; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX3 regulates p14-ARF; RUNX2 regulates chondrocyte maturation" "MicroRNAs in cardiomyocyte hypertrophy; Genes targeted by miRNAs in adipocytes; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; 2q37 copy number variation syndrome" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3032211375385727038" "False" "High" "IsMasterProtein" "Q15388" "Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1" "0.001" "False" "3.620" "9" "1" "1" "1" "145" "16.3" "8.60" "1.92" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf02064" "9804" "ENSG00000173726" "TOMM20" "A8K195; hsa:9804; Q15388; Q498B3; Q6IBT4" "Ub-specific processing proteases; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "513337833647549896" "False" "High" "IsMasterProtein" "P11717" "Cation-independent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3" "0.001" "False" "3.607" "1" "2" "2" "2" "2491" "274.2" "5.94" "4.65" "2" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00040, Pf00878" "3482" "ENSG00000197081" "IGF2R" "hsa:3482; P11717; Q7Z7G9; Q96PT5" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "TROP2 regulatory signaling" "6" "0" "1.192" "1.074" "1.291" "1.215" "1.184" "1.034" "1.143" "1.313" "1.025" "76.1" "90.7" "81.7" "98.2" "92.5" "90.1" "78.7" "86.9" "99.9" "78.0" "" "" "" "" "" "" "" "" "" "" "68.7" "70.0" "63.2" "66.1" "77.1" "76.9" "66.7" "62.9" "67.4" "78.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4925331307854051957" "False" "High" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "0.001" "False" "3.607" "2" "1" "1" "1" "615" "70.7" "9.36" "3.43" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "Gastric cancer network 2; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5010086175827698668" "False" "High" "IsMasterProtein" "P42575" "Caspase-2 OS=Homo sapiens OX=9606 GN=CASP2 PE=1 SV=2" "0.001" "False" "3.607" "2" "1" "1" "1" "452" "50.7" "6.81" "2.66" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00619, Pf00656" "835" "ENSG00000106144" "CASP2" "A8K5F9; D3DXD6; E9PDN0; hsa:835; P42575; P42576; Q59F21; Q7KZL6; Q86UJ3; Q9BUP7; Q9BZK9; Q9BZL0" "TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling" "Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3969710029576412220" "False" "High" "IsMasterProtein" "Q9Y3T6" "R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3" "0.001" "False" "3.606" "3" "1" "1" "1" "440" "49.1" "5.63" "4.64" "1" "" "" "nucleic acid binding activity" "Pf01424" "203069" "ENSG00000104679" "R3HCC1" "B7ZLI1; hsa:203069; Q9Y3T6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-443661170883717287" "False" "High" "IsMasterProtein" "Q9NQ92" "Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3" "0.001" "False" "3.601" "7" "1" "2" "1" "184" "20.1" "4.18" "1.94" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf15340" "55352" "ENSG00000172301" "COPRS" "A6NP14; E1P656; hsa:55352; Q96EF5; Q96P75; Q9NQ92" "RMTs methylate histone arginines" "NF1 copy number variation syndrome" "2" "0" "0.945" "0.906" "1.098" "0.909" "0.860" "1.014" "0.938" "0.932" "0.739" "24.7" "23.4" "22.4" "27.2" "22.5" "21.3" "25.1" "23.2" "23.1" "18.3" "" "" "" "" "" "" "" "" "" "" "22.3" "18.0" "17.3" "18.3" "18.8" "18.2" "21.3" "16.8" "15.5" "18.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7153575726197497326" "False" "High" "IsMasterProtein" "Q7Z6B0" "Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2" "0.001" "False" "3.597" "3" "2" "2" "2" "441" "49.9" "5.07" "4.35" "2" "transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "55297" "ENSG00000123106" "CCDC91" "B3KSA3; C9JR07; hsa:55297; Q68D43; Q6IA78; Q7Z6B0; Q8NEN7; Q9NUW9" "" "" "0" "0" "0.807" "0.826" "0.867" "0.855" "0.888" "0.965" "0.882" "0.780" "0.790" "134.7" "108.7" "111.2" "116.8" "115.2" "119.7" "130.0" "118.9" "105.1" "106.5" "" "" "" "" "" "" "" "" "" "" "121.6" "83.8" "86.0" "78.6" "96.1" "102.2" "110.3" "86.1" "70.9" "106.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2083560476411538397" "False" "High" "IsMasterProtein" "O15047" "Histone-lysine N-methyltransferase SETD1A OS=Homo sapiens OX=9606 GN=SETD1A PE=1 SV=3" "0.001" "False" "3.597" "1" "1" "1" "1" "1707" "185.9" "5.14" "2.72" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00856, Pf11764" "9739" "ENSG00000099381" "SETD1A" "A6NP62; hsa:9739; O15047; Q6PIF3; Q8TAJ6" "Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Histone modifications" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7708170732071910709" "False" "High" "IsMasterProtein" "O96013" "Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1" "0.001" "False" "3.594" "1" "1" "2" "1" "591" "64.0" "9.73" "5.74" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00786" "10298" "ENSG00000130669" "PAK4" "B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle" "Integrin-mediated cell adhesion; Focal adhesion; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway" "25" "0" "1.094" "0.773" "1.087" "1.070" "0.846" "1.004" "0.978" "1.039" "1.218" "61.1" "66.9" "47.2" "66.4" "65.4" "51.7" "61.4" "59.8" "63.5" "74.4" "" "" "" "" "" "" "" "" "" "" "55.2" "51.6" "36.5" "44.7" "54.6" "44.1" "52.1" "43.3" "42.8" "74.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5929165091375925329" "False" "High" "IsMasterProtein" "Q15545" "Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1" "0.001" "False" "3.586" "5" "2" "2" "2" "349" "40.2" "5.20" "6.00" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04658" "6879" "ENSG00000178913" "TAF7" "B2RBV9; hsa:6879; Q13036; Q15545" "RNA Polymerase II Pre-transcription Events; Regulation of TP53 Activity through Phosphorylation; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "Eukaryotic transcription initiation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794813676372242912" "False" "High" "IsMasterProtein" "Q96MW5" "Conserved oligomeric Golgi complex subunit 8 OS=Homo sapiens OX=9606 GN=COG8 PE=1 SV=2" "0.001" "False" "3.580" "1" "1" "1" "1" "612" "68.4" "5.20" "3.49" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf04124" "84342" "ENSG00000213380" "COG8" "hsa:84342; Q0VAK2; Q8WVV6; Q96MW5; Q9H6F8" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "1.115" "0.972" "0.921" "1.024" "0.922" "1.139" "0.105" "1.160" "9.022" "25.3" "28.2" "24.6" "23.3" "25.9" "23.3" "28.8" "2.7" "29.3" "228.3" "" "" "" "" "" "" "" "" "" "" "22.8" "21.8" "19.0" "15.7" "21.6" "19.9" "24.4" "1.9" "19.8" "228.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2750317325017084074" "False" "High" "IsMasterProtein" "Q12962" "Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1" "0.001" "False" "3.572" "4" "1" "1" "1" "218" "21.7" "6.57" "2.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03540" "6881" "ENSG00000166337" "TAF10" "hsa:6881; O00703; Q12962; Q13175; Q6FH13" "Ub-specific processing proteases; HATs acetylate histones; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "11" "0" "0.942" "0.776" "0.998" "1.137" "1.142" "0.954" "0.935" "1.055" "1.139" "33.5" "31.5" "26.0" "33.4" "38.1" "38.2" "31.9" "31.3" "35.3" "38.1" "" "" "" "" "" "" "" "" "" "" "30.2" "24.3" "20.1" "22.5" "31.8" "32.6" "27.1" "22.6" "23.8" "38.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802815428408388451" "False" "High" "IsMasterProtein" "Q9UK99" "F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3" "0.001" "False" "3.566" "2" "1" "1" "1" "471" "54.5" "5.00" "3.12" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00646, Pf04379, Pf09346" "26273" "ENSG00000110429" "FBXO3" "B3KY16; D3DR05; hsa:26273; Q86X90; Q9H0V2; Q9NUX2; Q9UK99" "" "" "0" "0" "1.477" "0.877" "1.531" "1.177" "0.928" "1.050" "1.041" "1.232" "1.135" "47.7" "70.4" "41.8" "73.0" "56.2" "44.2" "50.1" "49.6" "58.8" "54.1" "" "" "" "" "" "" "" "" "" "" "43.1" "54.3" "32.3" "49.2" "46.8" "37.8" "42.5" "35.9" "39.6" "54.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449078799256658420" "False" "High" "IsMasterProtein" "Q53FA7" "Quinone oxidoreductase PIG3 OS=Homo sapiens OX=9606 GN=TP53I3 PE=1 SV=2" "0.001" "False" "3.565" "3" "1" "1" "1" "332" "35.5" "7.17" "3.03" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00107, Pf08240" "9540" "ENSG00000115129" "TP53I3" "D6W533; hsa:9540; O14679; O14685; Q38G78; Q53FA7; Q6JLE7; Q9BWB8" "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "p53 transcriptional gene network; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "3" "0" "1.240" "1.047" "1.051" "1.220" "1.412" "1.165" "1.116" "1.186" "0.823" "60.3" "74.8" "63.1" "63.4" "73.6" "85.2" "70.3" "67.3" "71.6" "49.7" "" "" "" "" "" "" "" "" "" "" "54.4" "57.7" "48.8" "42.7" "61.4" "72.7" "59.6" "48.7" "48.3" "49.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2898803308841595735" "False" "High" "IsMasterProtein" "O00182" "Galectin-9 OS=Homo sapiens OX=9606 GN=LGALS9 PE=1 SV=2" "0.001" "False" "3.554" "4" "1" "3" "1" "355" "39.5" "9.17" "2.10" "1" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00337" "3965" "ENSG00000168961" "LGALS9" "A7VJG6; F8W9W4; hsa:3965; O00182; O14532; O75028; Q3B8N1; Q53FQ0; Q8WYQ7; Q9NQ58" "Interleukin-2 family signaling" "Vitamin D receptor pathway; Pleural mesothelioma; Immune infiltration in pancreatic cancer" "4" "0" "0.921" "1.149" "1.117" "0.670" "1.126" "0.951" "1.000" "1.144" "0.871" "28.2" "26.0" "32.4" "31.5" "18.9" "31.8" "26.8" "28.2" "32.2" "24.5" "" "" "" "" "" "" "" "" "" "" "25.4" "20.0" "25.1" "21.2" "15.7" "27.1" "22.7" "20.4" "21.8" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3184795118132692170" "False" "High" "IsMasterProtein" "P10636" "Microtubule-associated protein tau OS=Homo sapiens OX=9606 GN=MAPT PE=1 SV=5" "0.001" "False" "3.543" "1" "1" "1" "1" "758" "78.9" "6.71" "2.84" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00418" "4137" "ENSG00000186868; ENSG00000276155; ENSG00000277956" "MAPT" "hsa:4137; P10636; P18518; Q14799; Q15549; Q15550; Q15551; Q1RMF6; Q53YB1; Q5CZI7; Q5XWF0; Q6QT54; Q9UDJ3; Q9UMH0; Q9UQ96" "Caspase-mediated cleavage of cytoskeletal proteins" "IL-5 signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Copper homeostasis; MAPK signaling pathway; IL-2 signaling pathway; Inclusion body myositis; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; HDAC6 interactions in the central nervous system" "14" "0" "1.008" "1.074" "1.123" "0.856" "0.972" "1.125" "1.350" "1.075" "0.950" "95.6" "96.3" "102.7" "107.3" "81.8" "93.0" "107.5" "129.1" "102.8" "90.8" "" "" "" "" "" "" "" "" "" "" "86.3" "74.3" "79.4" "72.3" "68.2" "79.3" "91.2" "93.4" "69.3" "90.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8150428688248319822" "False" "High" "IsMasterProtein" "Q9H400" "Lck-interacting transmembrane adapter 1 OS=Homo sapiens OX=9606 GN=LIME1 PE=1 SV=1" "0.001" "False" "3.541" "3" "1" "1" "1" "295" "31.3" "9.58" "4.24" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15332" "54923" "ENSG00000203896" "LIME1" "E1P5K5; E1P5K6; hsa:54923; Q5JWJ2; Q6XYB3; Q9H400; Q9NX69" "" "" "0" "0" "1.111" "1.149" "1.076" "1.144" "0.935" "1.216" "1.084" "1.040" "1.057" "62.9" "69.9" "72.3" "67.7" "72.0" "58.9" "76.5" "68.2" "65.5" "66.5" "" "" "" "" "" "" "" "" "" "" "56.8" "53.9" "55.9" "45.6" "60.1" "50.2" "64.9" "49.4" "44.1" "66.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3066040936717898467" "False" "High" "IsMasterProtein" "Q8NC60" "Nitric oxide-associated protein 1 OS=Homo sapiens OX=9606 GN=NOA1 PE=1 SV=2" "0.001" "False" "3.539" "2" "2" "2" "2" "698" "78.4" "8.66" "5.70" "2" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf01926, Pf21516" "84273" "ENSG00000084092" "NOA1" "hsa:84273; Q8N7L6; Q8NC60; Q9BSQ9" "" "" "0" "0" "0.925" "0.738" "0.707" "0.810" "0.732" "0.842" "0.908" "0.778" "1.094" "211.3" "195.5" "155.9" "149.3" "171.2" "154.6" "178.0" "191.8" "164.4" "231.2" "" "" "" "" "" "" "" "" "" "" "190.7" "150.8" "120.6" "100.6" "142.8" "132.0" "151.0" "138.8" "110.9" "231.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8127220465279111592" "False" "High" "IsMasterProtein" "P17677" "Neuromodulin OS=Homo sapiens OX=9606 GN=GAP43 PE=1 SV=1" "0.001" "False" "3.531" "5" "1" "2" "1" "238" "24.8" "4.72" "2.99" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00612, Pf06614, Pf10580" "2596" "ENSG00000172020" "GAP43" "A8K0Y4; hsa:2596; P17677" "L1CAM interactions" "Glial cell differentiation; Spinal cord injury" "3" "0" "0.905" "1.704" "1.244" "1.020" "1.339" "1.231" "1.381" "1.494" "0.678" "36.6" "33.1" "62.4" "45.5" "37.3" "49.0" "45.1" "50.6" "54.7" "24.8" "" "" "" "" "" "" "" "" "" "" "33.0" "25.6" "48.2" "30.7" "31.1" "41.8" "38.2" "36.6" "36.9" "24.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8388783144784420231" "False" "High" "IsMasterProtein" "P82930" "Small ribosomal subunit protein mS34 OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" "0.001" "False" "3.521" "6" "2" "2" "2" "218" "25.6" "9.98" "4.82" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf16053" "65993" "ENSG00000074071" "MRPS34" "hsa:65993; P82930; Q9BVI7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.997" "0.849" "1.001" "1.070" "1.037" "0.916" "1.039" "0.988" "0.884" "197.7" "197.1" "167.9" "198.0" "211.5" "205.0" "181.1" "205.4" "195.3" "174.7" "" "" "" "" "" "" "" "" "" "" "178.4" "152.0" "129.9" "133.3" "176.5" "175.0" "153.6" "148.7" "131.7" "174.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3672343249527762985" "False" "High" "IsMasterProtein" "Q9H8M7" "Ubiquitin carboxyl-terminal hydrolase MINDY-3 OS=Homo sapiens OX=9606 GN=MINDY3 PE=1 SV=1" "0.001" "False" "3.511" "2" "1" "2" "1" "445" "49.7" "4.77" "6.95" "1" "protein metabolism;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13898" "80013" "ENSG00000148481" "MINDY3" "Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4; Q9H8M7" "" "" "0" "0" "0.937" "1.318" "0.881" "1.003" "1.057" "1.189" "1.157" "1.125" "0.822" "95.7" "89.7" "126.1" "84.3" "96.0" "101.1" "113.8" "110.7" "107.7" "78.7" "" "" "" "" "" "" "" "" "" "" "86.4" "69.2" "97.5" "56.8" "80.1" "86.3" "96.5" "80.1" "72.6" "78.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8411894831205011543" "False" "High" "IsMasterProtein" "Q7L8J4" "SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1" "0.001" "False" "3.508" "2" "1" "1" "1" "393" "43.5" "5.77" "2.96" "1" "signal transduction" "other cell component" "enzyme regulator activity" "Pf05276" "80851" "ENSG00000175137" "SH3BP5L" "B4DQ94; hsa:80851; Q7L8J4; Q96FI5; Q9BQH8; Q9C0E3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8486015732534254879" "False" "High" "IsMasterProtein" "Q7Z5W3" "RNA 5'-monophosphate methyltransferase OS=Homo sapiens OX=9606 GN=BCDIN3D PE=1 SV=1" "0.001" "False" "3.508" "3" "1" "1" "1" "292" "33.2" "6.70" "2.45" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "144233" "ENSG00000186666" "BCDIN3D" "A8K829; hsa:144233; Q7Z5W3" "MicroRNA (miRNA) biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2080335372413913728" "False" "High" "IsMasterProtein" "O60331" "Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma OS=Homo sapiens OX=9606 GN=PIP5K1C PE=1 SV=2" "0.001" "False" "3.507" "3" "2" "2" "1" "668" "73.2" "5.29" "2.68" "2" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "23396" "ENSG00000186111" "PIP5K1C" "B7Z9E7; C6GIJ7; C6GIJ8; hsa:23396; O60331; Q7LE07" "Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" "B cell receptor signaling pathway; Focal adhesion; Regulation of actin cytoskeleton" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8890451219668255439" "False" "High" "IsMasterProtein" "Q9NZC9" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Homo sapiens OX=9606 GN=SMARCAL1 PE=1 SV=1" "0.001" "False" "3.501" "2" "2" "2" "2" "954" "105.9" "9.06" "4.02" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07443" "50485" "ENSG00000138375" "SMARCAL1" "A6NEH0; hsa:50485; Q53R00; Q96AY1; Q9NXQ5; Q9NZC9; Q9UFH3; Q9UI93" "" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "879339039440763847" "False" "High" "IsMasterProtein" "A6NI72" "Putative neutrophil cytosol factor 1B OS=Homo sapiens OX=9606 GN=NCF1B PE=5 SV=2" "0.001" "False" "3.499" "4" "2" "2" "2" "391" "44.8" "9.13" "4.82" "2" "other metabolic processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf08944, Pf16621" "" "" "NCF1B" "A6NI72" "" "" "0" "0" "1.075" "0.887" "0.989" "1.054" "0.961" "0.950" "0.918" "1.164" "3.120" "69.6" "74.9" "61.8" "68.9" "73.4" "66.9" "66.1" "63.9" "81.1" "217.3" "" "" "" "" "" "" "" "" "" "" "62.9" "57.7" "47.8" "46.4" "61.2" "57.1" "56.1" "46.2" "54.7" "217.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4890653308716064100" "False" "High" "IsMasterProtein" "Q9H981" "Actin-related protein 8 OS=Homo sapiens OX=9606 GN=ACTR8 PE=1 SV=2" "0.001" "False" "3.494" "1" "1" "2" "1" "624" "70.4" "7.78" "4.90" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf00022" "93973" "ENSG00000113812" "ACTR8" "B3KSW7; hsa:93973; Q8N566; Q9H663; Q9H981" "UCH proteinases; DNA Damage Recognition in GG-NER" "" "2" "0" "1.091" "0.992" "1.074" "1.120" "0.858" "1.033" "0.718" "1.068" "8.480" "71.5" "78.0" "70.9" "76.7" "80.0" "61.4" "73.8" "51.3" "76.4" "606.1" "" "" "" "" "" "" "" "" "" "" "64.5" "60.2" "54.8" "51.7" "66.7" "52.4" "62.6" "37.1" "51.5" "606.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-781411655815037660" "False" "High" "IsMasterProtein" "P14316" "Interferon regulatory factor 2 OS=Homo sapiens OX=9606 GN=IRF2 PE=1 SV=2" "0.001" "False" "3.491" "2" "1" "1" "1" "349" "39.3" "7.52" "3.81" "1" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605" "3660" "ENSG00000168310" "IRF2" "D6RCK5; H0Y8S3; hsa:3660; P14316; Q6IAS7; Q96B99" "Interferon gamma signaling; Factors involved in megakaryocyte development and platelet production; Interferon alpha/beta signaling; Pyroptosis" "Apoptosis; Rubinstein-Taybi syndrome 1; Type II interferon signaling" "7" "0" "0.926" "0.878" "0.995" "0.937" "0.844" "1.001" "1.017" "0.765" "1.298" "95.2" "88.2" "83.6" "94.7" "89.2" "80.3" "95.3" "96.8" "72.8" "123.5" "" "" "" "" "" "" "" "" "" "" "85.9" "68.0" "64.7" "63.8" "74.4" "68.5" "80.9" "70.1" "49.1" "123.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3125031583536319160" "False" "High" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "0.001" "False" "3.481" "9" "1" "1" "1" "90" "9.4" "9.99" "2.83" "1" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "1.292" "1.754" "1.087" "1.128" "1.479" "1.087" "1.390" "1.727" "0.740" "144.1" "186.1" "252.8" "156.6" "162.5" "213.1" "156.6" "200.3" "248.9" "106.7" "" "" "" "" "" "" "" "" "" "" "130.1" "143.6" "195.5" "105.5" "135.5" "181.9" "132.8" "145.0" "167.9" "106.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110732802669380645" "False" "High" "IsMasterProtein" "P24864" "G1/S-specific cyclin-E1 OS=Homo sapiens OX=9606 GN=CCNE1 PE=1 SV=2" "0.001" "False" "3.475" "3" "1" "1" "1" "410" "47.0" "6.04" "4.82" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf02984" "898" "ENSG00000105173" "CCNE1" "A8K684; hsa:898; P24864; Q14091; Q8NFG1; Q92501; Q9UD21" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G1/S-Specific Transcription; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; Photodynamic therapy-induced AP-1 survival signaling; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; p53 transcriptional gene network; Pleural mesothelioma; GDNF signaling; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; NF1 copy number variation syndrome ; DNA damage response" "38" "0" "1.051" "1.218" "1.115" "1.057" "1.244" "0.933" "1.068" "1.201" "0.830" "80.1" "84.2" "97.5" "89.2" "84.6" "99.6" "74.7" "85.5" "96.1" "66.4" "" "" "" "" "" "" "" "" "" "" "72.3" "64.9" "75.4" "60.1" "70.6" "85.0" "63.4" "61.9" "64.8" "66.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330656270512848682" "False" "High" "IsMasterProtein" "Q8WVR3" "Trafficking protein particle complex subunit 14 OS=Homo sapiens OX=9606 GN=TRAPPC14 PE=1 SV=2" "0.001" "False" "3.471" "3" "1" "1" "1" "580" "62.6" "8.87" "2.86" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf15806" "55262" "ENSG00000146826" "TRAPPC14" "A4D2A9; D6W5U4; hsa:55262; Q8WVR3; Q9BQJ1; Q9BUB6; Q9NV47" "" "" "0" "0" "1.191" "0.992" "1.262" "1.120" "1.055" "1.009" "0.874" "0.705" "1.159" "33.9" "40.4" "33.6" "42.8" "38.0" "35.8" "34.2" "29.6" "23.9" "39.3" "" "" "" "" "" "" "" "" "" "" "30.6" "31.1" "26.0" "28.8" "31.7" "30.5" "29.0" "21.4" "16.1" "39.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4065169870199249389" "False" "High" "IsMasterProtein" "Q86VP1" "Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2" "0.001" "False" "3.469" "1" "1" "1" "1" "789" "90.8" "5.43" "2.80" "1" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07888, Pf17751, Pf18112" "8887" "ENSG00000106052" "TAX1BP1" "A4D196; B4DKU7; E7ENV2; hsa:8887; O60398; O95770; Q13311; Q86VP1; Q9BQG5; Q9UI88" "Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "" "2" "0" "1.083" "1.016" "1.067" "0.936" "0.984" "1.000" "1.051" "0.956" "1.095" "71.1" "77.0" "72.2" "75.9" "66.6" "70.0" "71.1" "74.8" "68.0" "77.9" "" "" "" "" "" "" "" "" "" "" "64.2" "59.4" "55.9" "51.1" "55.5" "59.7" "60.3" "54.1" "45.8" "77.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3115321329155830276" "False" "High" "IsMasterProtein" "Q9P2D0" "Inhibitor of Bruton tyrosine kinase OS=Homo sapiens OX=9606 GN=IBTK PE=1 SV=3" "0.001" "False" "3.463" "1" "1" "1" "1" "1353" "150.4" "7.71" "3.00" "1" "transport;other biological processes" "other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf00651, Pf12796" "25998" "ENSG00000005700; ENSG00000283068" "IBTK" "hsa:25998; Q2QKU2; Q2QKU3; Q2QKU4; Q5TFD7; Q5TFD9; Q8IUQ9; Q8IUY7; Q8TAI4; Q9HBI8; Q9P2D0; Q9Y3T8" "" "Genetic causes of porto-sinusoidal vascular disease" "1" "0" "1.150" "1.167" "1.070" "1.343" "1.183" "1.435" "1.315" "0.823" "1.313" "23.4" "26.9" "27.3" "25.1" "31.5" "27.7" "33.6" "30.8" "19.3" "30.8" "" "" "" "" "" "" "" "" "" "" "21.1" "20.8" "21.1" "16.9" "26.3" "23.7" "28.5" "22.3" "13.0" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "307320246962858459" "False" "High" "IsMasterProtein" "Q6UWZ7" "BRCA1-A complex subunit Abraxas 1 OS=Homo sapiens OX=9606 GN=ABRAXAS1 PE=1 SV=2" "0.001" "False" "3.463" "2" "1" "1" "1" "409" "46.6" "7.05" "3.38" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "cytoskeletal activity;other molecular function" "Pf21125" "84142" "ENSG00000163322" "ABRAXAS1" "A5JJ07; hsa:84142; Q6UWZ7; Q9H8I1; Q9H9N4" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "5q35 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7321680242331923571" "False" "High" "IsMasterProtein" "Q96EI5" "Transcription elongation factor A protein-like 4 OS=Homo sapiens OX=9606 GN=TCEAL4 PE=1 SV=2" "0.001" "False" "3.455" "4" "1" "2" "1" "215" "24.6" "5.20" "7.31" "1" "" "nucleus" "" "Pf04538" "79921" "ENSG00000133142" "TCEAL4" "hsa:79921; Q8WY12; Q96EI5; Q9H2H1; Q9H775" "" "" "0" "0" "0.892" "0.842" "1.239" "0.904" "0.967" "1.013" "1.133" "1.140" "0.858" "37.9" "33.8" "31.9" "47.0" "34.3" "36.7" "38.4" "43.0" "43.2" "32.5" "" "" "" "" "" "" "" "" "" "" "34.2" "26.1" "24.7" "31.6" "28.6" "31.3" "32.6" "31.1" "29.1" "32.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2614245215378921803" "False" "High" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "0.001" "False" "3.449" "2" "1" "1" "1" "362" "41.4" "9.28" "3.61" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "HATs acetylate histones" "Pathways affected in adenoid cystic carcinoma" "2" "0" "0.975" "0.874" "0.863" "0.838" "0.863" "0.945" "0.877" "0.950" "1.809" "106.8" "104.1" "93.3" "92.2" "89.5" "92.1" "100.9" "93.7" "101.4" "193.1" "" "" "" "" "" "" "" "" "" "" "96.4" "80.3" "72.2" "62.1" "74.7" "78.6" "85.6" "67.8" "68.4" "193.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2746729675254705765" "False" "High" "IsMasterProtein" "Q6ZN18" "Zinc finger protein AEBP2 OS=Homo sapiens OX=9606 GN=AEBP2 PE=1 SV=2" "0.001" "False" "3.448" "4" "2" "2" "2" "517" "54.4" "5.21" "2.66" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "121536" "ENSG00000139154" "AEBP2" "hsa:121536; Q59FS5; Q6ZN18; Q6ZN62; Q96BG3" "PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "Histone modifications; Mesodermal commitment pathway; Interactome of polycomb repressive complex 2 (PRC2)" "5" "0" "0.906" "1.631" "0.885" "1.016" "1.551" "0.927" "0.954" "1.587" "2.043" "134.7" "122.0" "219.6" "119.2" "136.9" "208.9" "124.9" "128.5" "213.7" "275.1" "" "" "" "" "" "" "" "" "" "" "121.6" "94.1" "169.9" "80.3" "114.2" "178.3" "105.9" "93.0" "144.1" "275.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6183242122487478565" "False" "High" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "0.001" "False" "3.446" "15" "2" "2" "2" "164" "17.8" "5.03" "4.46" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "1.119" "0.850" "1.078" "1.185" "0.774" "1.139" "0.665" "1.011" "2.368" "32.4" "36.3" "27.6" "35.0" "38.5" "25.1" "37.0" "21.6" "32.8" "76.8" "" "" "" "" "" "" "" "" "" "" "29.3" "28.0" "21.3" "23.6" "32.1" "21.4" "31.4" "15.6" "22.1" "76.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4733081690105890722" "False" "High" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "0.001" "False" "3.443" "1" "1" "2" "1" "822" "91.9" "6.65" "5.30" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327969175985067622" "False" "High" "IsMasterProtein" "Q6I9Y2" "THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3" "0.001" "False" "3.439" "9" "2" "3" "2" "204" "23.7" "5.67" "6.75" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05615" "80145" "ENSG00000163634" "THOC7" "hsa:80145; Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1199984255511246690" "False" "High" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "0.001" "False" "3.438" "5" "2" "2" "2" "733" "75.4" "9.32" "4.97" "2" "other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "UCH proteinases" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8819989402744158112" "False" "High" "IsMasterProtein" "Q96EW2" "HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1" "0.001" "False" "3.424" "3" "2" "2" "2" "488" "55.1" "5.60" "5.79" "2" "" "other cell component" "other molecular function" "Pf13621" "79663" "ENSG00000169087" "HSPBAP1" "hsa:79663; Q6P476; Q8N8J4; Q8NHH6; Q8WWF0; Q96EW2" "" "" "0" "0" "1.094" "1.052" "1.207" "1.133" "1.018" "1.197" "1.123" "1.082" "1.058" "127.6" "139.6" "134.2" "154.0" "144.5" "129.9" "152.7" "143.3" "138.0" "135.0" "" "" "" "" "" "" "" "" "" "" "115.2" "107.7" "103.8" "103.7" "120.6" "110.8" "129.5" "103.7" "93.1" "135.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396121455567897427" "False" "High" "IsMasterProtein" "Q9Y4K1" "Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=4" "0.001" "False" "3.424" "1" "1" "1" "1" "2131" "231.6" "5.81" "2.73" "1" "" "" "other molecular function" "Pf00030, Pf00652" "" "ENSG00000112297" "CRYBG1" "A0A0J9YWL0" "" "" "0" "0" "0.997" "1.820" "1.149" "1.102" "1.529" "1.668" "0.904" "1.390" "1.811" "9.9" "9.9" "18.0" "11.4" "10.9" "15.1" "16.5" "8.9" "13.7" "17.9" "" "" "" "" "" "" "" "" "" "" "8.9" "7.6" "13.9" "7.7" "9.1" "12.9" "14.0" "6.5" "9.3" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8657126207816692356" "False" "High" "IsMasterProtein" "O43422" "52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens OX=9606 GN=THAP12 PE=1 SV=2" "0.001" "False" "3.422" "3" "2" "2" "2" "761" "87.6" "5.86" "4.32" "2" "signal transduction;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf05485, Pf05699, Pf14291" "5612" "ENSG00000137492" "THAP12" "A8K728; hsa:5612; O43422; Q17RY9; Q8WTW1; Q9Y3Z4" "" "" "0" "0" "0.960" "0.922" "1.251" "0.966" "0.698" "1.058" "0.873" "0.990" "1.349" "50.2" "48.2" "46.3" "62.8" "48.5" "35.0" "53.1" "43.8" "49.7" "67.7" "" "" "" "" "" "" "" "" "" "" "45.3" "37.2" "35.8" "42.3" "40.4" "29.9" "45.0" "31.7" "33.5" "67.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8029242028913948624" "False" "High" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "0.001" "False" "3.418" "1" "2" "2" "2" "2054" "233.0" "6.30" "4.33" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00595, Pf01576" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "" "3" "0" "0.815" "1.238" "1.032" "1.016" "0.905" "1.189" "1.134" "1.136" "2.596" "23.7" "19.3" "29.3" "24.5" "24.1" "21.4" "28.2" "26.9" "26.9" "61.5" "" "" "" "" "" "" "" "" "" "" "21.4" "14.9" "22.7" "16.5" "20.1" "18.3" "23.9" "19.4" "18.2" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3580192836813559225" "False" "High" "IsMasterProtein" "O95425" "Supervillin OS=Homo sapiens OX=9606 GN=SVIL PE=1 SV=2" "0.001" "False" "3.412" "1" "2" "2" "2" "2214" "247.6" "6.98" "5.42" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00626, Pf02209" "6840" "ENSG00000197321" "SVIL" "D3DRW9; hsa:6840; M1J557; O60611; O60612; O95425; Q5VZK5; Q5VZK6; Q9H1R7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2556880978610824670" "False" "High" "IsMasterProtein" "P62256" "Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1" "0.001" "False" "3.410" "4" "1" "1" "1" "183" "20.6" "4.67" "3.54" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "7328" "ENSG00000186591" "UBE2H" "A4D1L6; C9JY93; hsa:7328; P37286; P62256; Q7Z6F4" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "Ciliary landscape" "3" "0" "0.955" "0.969" "0.940" "0.966" "1.024" "0.941" "0.865" "1.069" "0.946" "179.5" "171.3" "174.0" "168.7" "173.4" "183.8" "168.9" "155.3" "191.9" "169.8" "" "" "" "" "" "" "" "" "" "" "162.0" "132.2" "134.6" "113.6" "144.7" "156.9" "143.3" "112.4" "129.4" "169.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049271637643204736" "False" "High" "IsMasterProtein" "Q96F63" "Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1" "0.001" "False" "3.403" "7" "1" "1" "1" "343" "38.9" "4.59" "2.27" "1" "" "nucleus" "" "Pf09747" "90324" "ENSG00000142039" "CCDC97" "hsa:90324; Q658N6; Q96F63; Q96IF3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "High" "High" "High" "High" "High" "1" "" "8872418037025781977" "False" "High" "IsMasterProtein" "Q5VTB9" "E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens OX=9606 GN=RNF220 PE=1 SV=1" "0.001" "False" "3.399" "2" "1" "1" "1" "566" "62.7" "6.04" "3.24" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf15926" "55182" "ENSG00000187147" "RNF220" "B3KPJ3; B4DLZ9; E9PCS1; hsa:55182; Q4KMX2; Q5VTB9; Q9NVP6" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "0.865" "0.761" "0.899" "0.793" "0.801" "0.906" "0.838" "0.821" "0.885" "89.2" "77.1" "67.8" "80.2" "70.8" "71.4" "80.8" "74.7" "73.2" "78.9" "" "" "" "" "" "" "" "" "" "" "80.5" "59.5" "52.5" "54.0" "59.0" "61.0" "68.5" "54.1" "49.4" "78.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908958946430001431" "False" "High" "IsMasterProtein" "O60333" "Kinesin-like protein KIF1B OS=Homo sapiens OX=9606 GN=KIF1B PE=1 SV=5" "0.001" "False" "3.396" "0" "1" "1" "1" "1816" "204.3" "5.60" "2.85" "1" "cell-cell signaling;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00225, Pf00498, Pf12423, Pf12473, Pf16183" "23095" "ENSG00000054523" "KIF1B" "A6NFS8; A6NKQ4; hsa:23095; O60333; Q4VXC3; Q4VXC4; Q4VXC5; Q4VXC6; Q96Q94; Q9BV80; Q9P280" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "Intracellular trafficking proteins involved in CMT neuropathy" "3" "0" "0.805" "0.878" "0.859" "0.852" "0.770" "0.805" "0.819" "0.804" "0.890" "127.7" "102.8" "112.1" "109.7" "108.7" "98.3" "102.8" "104.6" "102.6" "113.7" "" "" "" "" "" "" "" "" "" "" "115.2" "79.3" "86.7" "73.9" "90.7" "83.9" "87.2" "75.7" "69.2" "113.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904410846819458044" "False" "High" "IsMasterProtein" "Q92796" "Disks large homolog 3 OS=Homo sapiens OX=9606 GN=DLG3 PE=1 SV=2" "0.001" "False" "3.387" "2" "1" "1" "1" "817" "90.3" "7.03" "3.63" "1" "cell adhesion;cell-cell signaling;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600" "1741" "ENSG00000082458" "DLG3" "B4E0H1; D3DVU5; hsa:1741; Q5JUW6; Q5JUW7; Q92796; Q9ULI8" "RAF/MAP kinase cascade; Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "Cell lineage map for neuronal differentiation" "11" "0" "1.090" "0.908" "1.028" "0.853" "0.822" "1.029" "1.006" "0.826" "0.989" "91.5" "99.7" "83.0" "94.0" "78.0" "75.2" "94.2" "92.0" "75.6" "90.4" "" "" "" "" "" "" "" "" "" "" "82.6" "76.9" "64.2" "63.3" "65.1" "64.2" "79.9" "66.6" "51.0" "90.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871053517443562380" "False" "High" "IsMasterProtein" "P57772" "Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4" "0.001" "False" "3.387" "2" "1" "1" "1" "596" "65.3" "8.35" "2.74" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf21131, Pf21208" "60678" "ENSG00000132394; ENSG00000284869" "EEFSEC" "hsa:60678; P57772; Q96HZ6" "Selenocysteine synthesis" "Selenium metabolism and selenoproteins" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2429714834335380006" "False" "High" "IsMasterProtein" "P40818" "Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1" "0.001" "False" "3.387" "1" "1" "1" "1" "1118" "127.4" "8.51" "3.04" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf00581, Pf08969, Pf20625" "9101" "ENSG00000138592" "USP8" "B4DKA8; hsa:9101; P40818; Q2TB31; Q7Z3U2; Q86VA0; Q8IWI7" "Negative regulation of MET activity; Ub-specific processing proteases; Downregulation of ERBB2:ERBB3 signaling; Regulation of FZD by ubiquitination" "EGF/EGFR signaling pathway; Male infertility" "6" "0" "1.014" "1.066" "1.017" "1.057" "1.255" "0.943" "0.729" "1.087" "5.205" "31.7" "32.2" "33.8" "32.3" "33.5" "39.8" "29.9" "23.1" "34.5" "165.2" "" "" "" "" "" "" "" "" "" "" "28.7" "24.8" "26.2" "21.7" "28.0" "34.0" "25.4" "16.7" "23.3" "165.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7526904377414410620" "False" "High" "IsMasterProtein" "Q6NXR4" "TELO2-interacting protein 2 OS=Homo sapiens OX=9606 GN=TTI2 PE=1 SV=1" "0.001" "False" "3.386" "3" "2" "2" "2" "508" "56.9" "7.09" "2.37" "2" "other biological processes" "nucleus;other cell component" "" "Pf10521" "80185" "ENSG00000129696" "TTI2" "D3DSV7; hsa:80185; Q6NXR4; Q96IM2; Q9H5N4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984281592385059565" "False" "High" "IsMasterProtein" "Q6ZU35" "Capping protein-inhibiting regulator of actin dynamics OS=Homo sapiens OX=9606 GN=CRACD PE=1 SV=3" "0.001" "False" "3.384" "1" "1" "1" "1" "1233" "136.7" "5.60" "3.18" "1" "cell organization and biogenesis;other biological processes" "cytosol" "" "Pf15262" "57482" "ENSG00000109265" "CRACD" "hsa:57482; Q6ZU35; Q9NTE2; Q9NTP8; Q9ULK9" "" "" "0" "0" "0.962" "1.040" "0.988" "0.977" "1.059" "1.187" "1.099" "1.085" "0.816" "37.3" "35.9" "38.8" "36.8" "36.4" "39.5" "44.2" "41.0" "40.5" "30.4" "" "" "" "" "" "" "" "" "" "" "33.6" "27.7" "30.0" "24.8" "30.4" "33.7" "37.5" "29.7" "27.3" "30.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5234927014907967079" "False" "High" "IsMasterProtein" "Q9H0S4" "Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1" "0.001" "False" "3.379" "2" "1" "1" "1" "455" "50.6" "9.10" "2.88" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "nucleus" "other molecular function" "Pf00270, Pf00271" "51202" "ENSG00000213782" "DDX47" "B3KXP4; G5E955; hsa:51202; Q96GM0; Q96NV8; Q9H0S4; Q9UI98" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193140464994973163" "False" "High" "IsMasterProtein" "P49711" "Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1" "0.001" "False" "3.376" "2" "2" "2" "2" "727" "82.7" "6.96" "2.14" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10664" "ENSG00000102974" "CTCF" "B5MC38; hsa:10664; P49711; Q53XI7; Q59EL8" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "MECP2 and associated Rett syndrome; Prion disease pathway; Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "0.794" "0.821" "0.746" "0.851" "0.915" "0.839" "0.928" "0.821" "0.855" "45.6" "36.2" "37.5" "34.1" "38.8" "41.8" "38.3" "42.3" "37.5" "39.0" "" "" "" "" "" "" "" "" "" "" "41.2" "28.0" "29.0" "22.9" "32.4" "35.7" "32.5" "30.6" "25.3" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3766879511259281877" "False" "High" "IsMasterProtein" "Q96CM8" "Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2" "0.001" "False" "3.371" "2" "1" "1" "1" "615" "68.1" "7.55" "3.61" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "80221" "ENSG00000167107" "ACSF2" "B4DFQ6; B4DHT5; B4DUF5; hsa:80221; Q96CM8; Q9H7G2" "Mitochondrial Fatty Acid Beta-Oxidation" "Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "3" "0" "1.100" "0.916" "1.217" "1.158" "1.173" "1.469" "1.267" "1.141" "1.776" "100.5" "110.5" "92.1" "122.3" "116.4" "117.9" "147.7" "127.3" "114.6" "178.4" "" "" "" "" "" "" "" "" "" "" "90.7" "85.3" "71.2" "82.4" "97.1" "100.7" "125.3" "92.1" "77.3" "178.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4410933930265088231" "False" "High" "IsMasterProtein" "P14927" "Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2" "0.001" "False" "3.370" "10" "1" "1" "1" "111" "13.5" "8.78" "1.98" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02271" "7381" "ENSG00000156467" "UQCRB" "E5RJU0; hsa:7381; P14927; Q6FGD1" "Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-930823423680918184" "False" "High" "IsMasterProtein" "Q53H82" "Endoribonuclease LACTB2 OS=Homo sapiens OX=9606 GN=LACTB2 PE=1 SV=2" "0.001" "False" "3.370" "3" "1" "1" "1" "288" "32.8" "6.80" "2.90" "1" "" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00753, Pf17778" "51110" "ENSG00000147592" "LACTB2" "A8K2D6; hsa:51110; Q53H82; Q9Y392" "" "" "0" "0" "0.979" "0.932" "0.895" "0.994" "1.044" "0.946" "1.021" "0.911" "0.725" "129.7" "127.0" "120.9" "116.1" "128.9" "135.5" "122.7" "132.5" "118.1" "94.1" "" "" "" "" "" "" "" "" "" "" "117.1" "98.0" "93.5" "78.1" "107.5" "115.6" "104.1" "95.9" "79.7" "94.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2096625671163089170" "False" "High" "IsMasterProtein" "O95999" "B-cell lymphoma/leukemia 10 OS=Homo sapiens OX=9606 GN=BCL10 PE=1 SV=1" "0.001" "False" "3.368" "4" "1" "2" "1" "233" "26.2" "5.74" "5.04" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00619" "8915" "ENSG00000142867" "BCL10" "hsa:8915; O95999; Q5VUF1" "FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "9" "0" "1.131" "1.160" "1.248" "1.074" "1.226" "1.126" "0.964" "1.211" "2.105" "110.2" "124.7" "127.8" "137.5" "118.4" "135.0" "124.1" "106.3" "133.4" "232.0" "" "" "" "" "" "" "" "" "" "" "99.5" "96.2" "98.8" "92.6" "98.7" "115.3" "105.3" "76.9" "90.0" "232.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8251896987743937176" "False" "High" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "0.001" "False" "3.365" "11" "2" "2" "2" "142" "17.0" "6.18" "6.21" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "MHC class II antigen presentation; Potential therapeutics for SARS; Cargo recognition for clathrin-mediated endocytosis; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1273704181858751884" "False" "High" "IsMasterProtein" "Q8N0X4" "Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2" "0.001" "False" "3.365" "2" "1" "1" "1" "340" "37.3" "8.73" "3.06" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "other molecular function" "Pf03328" "171425" "ENSG00000125246" "CLYBL" "hsa:171425; Q5W0F7; Q8N0X4; Q8TDH8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5100891898626735389" "False" "High" "IsMasterProtein" "Q86WA6" "Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1" "0.001" "False" "3.364" "5" "2" "2" "2" "291" "32.5" "9.14" "5.05" "2" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00561" "670" "ENSG00000137274" "BPHL" "hsa:670; Q00306; Q13855; Q3KP51; Q86WA6" "Phase I - Functionalization of compounds" "" "1" "0" "1.001" "0.921" "1.118" "1.012" "1.052" "0.948" "1.027" "0.947" "0.752" "123.0" "123.0" "113.3" "137.4" "124.4" "129.4" "116.5" "126.2" "116.4" "92.5" "" "" "" "" "" "" "" "" "" "" "111.0" "94.9" "87.6" "92.5" "103.8" "110.4" "98.8" "91.3" "78.5" "92.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958262542107945679" "False" "High" "IsMasterProtein" "Q96C00" "Zinc finger and BTB domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ZBTB9 PE=1 SV=1" "0.001" "False" "3.363" "3" "1" "1" "1" "473" "50.6" "6.76" "3.55" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00651" "221504" "ENSG00000213588; ENSG00000236515" "ZBTB9" "A2AB19; hsa:221504; Q96C00" "" "" "0" "0" "1.055" "0.958" "1.098" "0.961" "0.907" "0.963" "1.106" "1.141" "1.407" "75.1" "79.3" "72.0" "82.5" "72.2" "68.2" "72.4" "83.1" "85.7" "105.7" "" "" "" "" "" "" "" "" "" "" "67.8" "61.2" "55.7" "55.6" "60.2" "58.2" "61.4" "60.1" "57.8" "105.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436639350970849740" "False" "High" "IsMasterProtein" "Q9UHB4" "NADPH-dependent diflavin oxidoreductase 1 OS=Homo sapiens OX=9606 GN=NDOR1 PE=1 SV=1" "0.001" "False" "3.359" "2" "1" "1" "1" "597" "66.7" "6.35" "3.12" "1" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "27158" "ENSG00000188566" "NDOR1" "D3YTG6; D3YTH9; hsa:27158; Q5VSG4; Q86US9; Q96BC6; Q9UHB4" "Cytosolic iron-sulfur cluster assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2748783261369810529" "False" "High" "IsMasterProtein" "P11182" "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4" "0.001" "False" "3.358" "2" "1" "1" "1" "482" "53.5" "8.51" "2.43" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6161986969394420318" "False" "High" "IsMasterProtein" "O95081" "Arf-GAP domain and FG repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=AGFG2 PE=1 SV=2" "0.001" "False" "3.353" "2" "1" "1" "1" "481" "48.9" "9.11" "2.58" "1" "" "other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "3268" "ENSG00000106351" "AGFG2" "hsa:3268; O75429; O95081; Q96AB9; Q96GL4" "" "" "0" "0" "0.787" "0.952" "0.884" "0.871" "0.810" "0.871" "0.472" "0.952" "5.303" "29.2" "23.0" "27.8" "25.9" "25.5" "23.7" "25.5" "13.8" "27.8" "155.1" "" "" "" "" "" "" "" "" "" "" "26.4" "17.7" "21.5" "17.4" "21.2" "20.2" "21.6" "10.0" "18.8" "155.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2329486021897558917" "False" "High" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "0.001" "False" "3.351" "2" "2" "2" "2" "998" "112.3" "6.39" "2.50" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "3" "0" "1.125" "0.708" "1.176" "1.165" "0.672" "1.020" "0.967" "0.724" "0.809" "60.2" "67.8" "42.7" "70.8" "70.2" "40.5" "61.4" "58.3" "43.6" "48.7" "" "" "" "" "" "" "" "" "" "" "54.4" "52.3" "33.0" "47.7" "58.5" "34.5" "52.1" "42.2" "29.4" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413974576400389324" "False" "High" "IsMasterProtein" "Q9NQT5" "Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3" "0.001" "False" "3.351" "5" "2" "4" "2" "275" "29.6" "8.10" "10.36" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf15985, Pf21261, Pf21262" "51010" "ENSG00000107371" "EXOSC3" "A8K0K6; hsa:51010; Q5QP85; Q9NQT5; Q9Y3A8" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "" "6" "0" "0.943" "0.779" "0.983" "0.946" "0.852" "0.929" "0.936" "0.908" "0.792" "321.5" "303.2" "250.4" "316.2" "304.2" "273.9" "298.8" "300.9" "291.9" "254.8" "" "" "" "" "" "" "" "" "" "" "290.2" "233.9" "193.7" "212.9" "253.7" "233.8" "253.5" "217.8" "196.8" "254.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819928772784180698" "False" "High" "IsMasterProtein" "Q03001" "Dystonin OS=Homo sapiens OX=9606 GN=DST PE=1 SV=4" "0.001" "False" "3.349" "0" "2" "2" "1" "7570" "860.1" "5.25" "4.91" "2" "cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "667" "ENSG00000151914" "DST" "B7Z3H1; E7ERU0; hsa:667; O94833; Q03001; Q12825; Q13266; Q13267; Q13775; Q5TBT0; Q5TBT2; Q5TF23; Q5TF24; Q8N1T8; Q8N8J3; Q8WXK8; Q8WXK9; Q96AK9; Q96DQ5; Q96J76; Q96QT5; Q9H555; Q9UGD7; Q9UGD8; Q9UN10" "RND1 GTPase cycle; RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; Type I hemidesmosome assembly" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2600718552513118007" "False" "High" "IsMasterProtein" "Q86VR2" "Reticulophagy regulator 3 OS=Homo sapiens OX=9606 GN=RETREG3 PE=1 SV=1" "0.001" "False" "3.347" "2" "1" "1" "1" "466" "51.4" "4.97" "2.75" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "" "162427" "ENSG00000141699" "RETREG3" "B3KR75; hsa:162427; Q86VR2" "" "" "0" "0" "0.942" "0.911" "1.106" "1.065" "0.978" "0.963" "0.934" "0.944" "0.857" "120.2" "113.2" "109.5" "132.9" "128.0" "117.5" "115.8" "112.3" "113.5" "103.0" "" "" "" "" "" "" "" "" "" "" "108.5" "87.3" "84.7" "89.5" "106.7" "100.3" "98.2" "81.2" "76.5" "103.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "29627463948576905" "False" "High" "IsMasterProtein" "Q9NUQ8" "ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2" "0.001" "False" "3.344" "1" "1" "1" "1" "709" "79.7" "6.34" "3.43" "1" "stress response" "" "other molecular function" "Pf00005, Pf12848" "55324" "ENSG00000161204" "ABCF3" "A8K241; hsa:55324; Q86UA2; Q8NAN1; Q96GS8; Q9H7A8; Q9NUQ8" "" "" "0" "0" "1.258" "1.131" "0.993" "1.091" "1.153" "1.089" "0.674" "1.190" "11.419" "28.4" "35.8" "32.2" "28.2" "31.0" "32.8" "30.9" "19.2" "33.8" "324.6" "" "" "" "" "" "" "" "" "" "" "25.7" "27.6" "24.9" "19.0" "25.9" "28.0" "26.3" "13.9" "22.8" "324.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6311792634323400615" "False" "High" "IsMasterProtein" "Q9NSU2" "Three-prime repair exonuclease 1 OS=Homo sapiens OX=9606 GN=TREX1 PE=1 SV=2" "0.001" "False" "3.341" "3" "1" "1" "1" "314" "33.2" "7.93" "4.32" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "11277" "ENSG00000213689" "TREX1" "B2RCN9; hsa:11277; Q8TEU2; Q9BPW1; Q9NSU2; Q9Y4X2" "IRF3-mediated induction of type I IFN; Regulation by TREX1" "Cytosolic DNA-sensing pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491250249564736583" "False" "High" "IsMasterProtein" "P49902" "Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1" "0.001" "False" "3.339" "2" "1" "1" "1" "561" "64.9" "6.14" "2.97" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf05761" "22978" "ENSG00000076685" "NT5C2" "B7Z382; D3DR91; hsa:22978; P49902; Q5JUV5" "Purine catabolism; Ribavirin ADME; Abacavir metabolism" "" "3" "0" "0.907" "1.078" "0.877" "0.955" "1.117" "0.812" "1.031" "1.174" "0.780" "119.6" "108.5" "129.0" "104.9" "114.2" "133.6" "97.1" "123.3" "140.4" "93.4" "" "" "" "" "" "" "" "" "" "" "108.0" "83.7" "99.8" "70.6" "95.3" "114.0" "82.4" "89.3" "94.7" "93.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6667232000809583596" "False" "High" "IsMasterProtein" "P22105" "Tenascin-X OS=Homo sapiens OX=9606 GN=TNXB PE=1 SV=5" "0.001" "False" "3.327" "0" "1" "1" "1" "4244" "458.1" "5.17" "2.72" "1" "cell adhesion;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "extracellular matrix;other cell component" "signal transduction activity or receptor binding;extracellular structural activity;other molecular function" "Pf00041, Pf00147, Pf07974, Pf18720" "7148" "ENSG00000168477; ENSG00000229353; ENSG00000236236" "TNXB" "hsa:7148; P22105; P78530; P78531; Q08424; Q08AM0; Q08AM1; Q59GU7; Q5SQD3; Q5ST74; Q7L8Q4; Q8N4R1; Q9NPK9; Q9UC10; Q9UC11; Q9UC12; Q9UC13; Q9UMG7" "ECM proteoglycans" "miRNA targets in ECM and membrane receptors; Focal adhesion; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "6" "0" "1.485" "2.210" "1.540" "1.876" "1.853" "1.576" "1.872" "2.495" "1.380" "28.1" "41.7" "62.1" "43.2" "52.7" "52.0" "44.3" "52.5" "70.1" "38.8" "" "" "" "" "" "" "" "" "" "" "25.3" "32.2" "48.0" "29.1" "43.9" "44.4" "37.5" "38.0" "47.3" "38.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699158399968223668" "False" "High" "IsMasterProtein" "Q15311" "RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3" "0.001" "False" "3.314" "1" "1" "2" "1" "655" "76.0" "5.88" "2.48" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus" "transporter activity;enzyme regulator activity;other molecular function" "Pf00620, Pf20924" "10928" "ENSG00000017797" "RALBP1" "D3DUI0; hsa:10928; Q15311" "CDC42 GTPase cycle; RAC1 GTPase cycle" "RalA downstream regulated genes; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8452919191869770403" "False" "High" "IsMasterProtein" "Q8WVV9" "Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1" "0.001" "False" "3.312" "3" "2" "2" "1" "542" "60.0" "7.72" "5.50" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "92906" "ENSG00000143889" "HNRNPLL" "hsa:92906; Q53T80; Q5JB51; Q5JB52; Q659B9; Q8IVH5; Q8IVH6; Q8WVV9; Q96HR5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723203762439641288" "False" "High" "IsMasterProtein" "Q9Y5N5" "Methyltransferase N6AMT1 OS=Homo sapiens OX=9606 GN=N6AMT1 PE=1 SV=4" "0.001" "False" "3.290" "4" "1" "1" "1" "214" "22.9" "5.11" "3.49" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29104" "ENSG00000156239" "N6AMT1" "B2RA97; hsa:29104; Q96F73; Q9Y5N5" "Eukaryotic Translation Termination; Methylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8207864549745438201" "False" "High" "IsMasterProtein" "Q96T76" "MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2" "0.001" "False" "3.275" "2" "2" "2" "2" "1030" "113.2" "6.35" "4.66" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12460, Pf14500" "64210" "ENSG00000155229" "MMS19" "B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2; hsa:64210; Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; Q96DF1; Q96MR1; Q96RK5; Q96SK1; Q96T76; Q9BUE2; Q9BYS9" "Cytosolic iron-sulfur cluster assembly" "2q11.2 copy number variation syndrome" "2" "0" "1.256" "1.018" "1.149" "1.190" "1.012" "1.034" "0.933" "1.229" "5.278" "95.0" "119.4" "96.8" "109.2" "113.1" "96.1" "98.3" "88.7" "116.9" "501.6" "" "" "" "" "" "" "" "" "" "" "85.8" "92.1" "74.8" "73.5" "94.4" "82.1" "83.4" "64.2" "78.8" "501.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887572586952269824" "False" "High" "IsMasterProtein" "Q9HCE1" "Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2" "0.001" "False" "3.273" "1" "1" "1" "1" "1003" "113.6" "8.82" "3.34" "1" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf21632, Pf21633, Pf21634, Pf21635" "4343" "ENSG00000155363" "MOV10" "hsa:4343; Q5JR03; Q8TEF0; Q9BSY3; Q9BUJ9; Q9HCE1" "TP53 Regulates Metabolic Genes; MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ca2+ pathway; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "VEGFA-VEGFR2 signaling" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904247061824975509" "False" "High" "IsMasterProtein" "Q9NP73" "UDP-N-acetylglucosamine transferase subunit ALG13 OS=Homo sapiens OX=9606 GN=ALG13 PE=1 SV=2" "0.001" "False" "3.272" "1" "1" "1" "1" "1137" "126.0" "6.74" "3.22" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02338, Pf04101" "79868" "ENSG00000101901" "ALG13" "B1AKD6; B1AKM1; B2R5L5; B7Z6J0; B7Z804; B7Z847; B7Z9A8; B7ZAJ1; B7ZB57; hsa:79868; Q17RC3; Q5JXY9; Q9H5U8; Q9NP73" "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS" "N-glycan biosynthesis" "3" "0" "0.971" "0.752" "0.822" "1.048" "0.895" "0.992" "1.066" "0.718" "1.114" "134.7" "130.8" "101.3" "110.8" "141.2" "120.6" "133.6" "143.6" "96.7" "150.1" "" "" "" "" "" "" "" "" "" "" "121.6" "100.9" "78.3" "74.6" "117.8" "102.9" "113.3" "103.9" "65.2" "150.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2370626703481031957" "False" "High" "IsMasterProtein" "Q9H7N4" "Splicing factor, arginine/serine-rich 19 OS=Homo sapiens OX=9606 GN=SCAF1 PE=1 SV=3" "0.001" "False" "3.271" "1" "1" "1" "1" "1312" "139.2" "9.25" "2.88" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "58506" "ENSG00000126461" "SCAF1" "hsa:58506; Q7Z5V7; Q8WVA1; Q9H7N4; Q9NR59" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-209810513370909151" "False" "High" "IsMasterProtein" "Q8NBJ4" "Golgi membrane protein 1 OS=Homo sapiens OX=9606 GN=GOLM1 PE=1 SV=1" "0.001" "False" "3.270" "2" "1" "1" "1" "401" "45.3" "4.97" "3.74" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi" "" "" "51280" "ENSG00000135052" "GOLM1" "hsa:51280; Q6IAF4; Q8NBJ4; Q9NRB9" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7145553044462341407" "False" "High" "IsMasterProtein" "Q8NI36" "WD repeat-containing protein 36 OS=Homo sapiens OX=9606 GN=WDR36 PE=1 SV=1" "0.001" "False" "3.261" "1" "1" "1" "1" "951" "105.3" "7.53" "2.55" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf04192, Pf12894" "134430" "" "WDR36" "A2RUS4; hsa:134430; Q68E02; Q8N1Q2; Q8NI36" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4474106479109079676" "False" "High" "IsMasterProtein" "O00422" "Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1" "0.001" "False" "3.261" "9" "2" "2" "2" "153" "17.6" "9.35" "4.33" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06487" "10284" "ENSG00000150459" "SAP18" "B2R494; hsa:10284; O00422; Q2TTR4; Q6IAW9; Q8N606; Q9UF14; X6RAL5" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway" "Hedgehog signaling pathway" "5" "0" "0.985" "0.874" "1.086" "0.949" "0.950" "0.932" "1.010" "0.823" "1.093" "130.3" "128.4" "113.9" "141.6" "123.7" "123.8" "121.4" "131.6" "107.3" "142.5" "" "" "" "" "" "" "" "" "" "" "117.6" "99.1" "88.1" "95.3" "103.2" "105.7" "103.0" "95.2" "72.4" "142.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "941703360025083073" "False" "High" "IsMasterProtein" "Q5JTC6" "APC membrane recruitment protein 1 OS=Homo sapiens OX=9606 GN=AMER1 PE=1 SV=2" "0.001" "False" "3.260" "2" "1" "1" "1" "1135" "124.0" "4.84" "2.43" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf09422" "139285" "ENSG00000184675" "AMER1" "A2IB86; hsa:139285; Q5JTC6; Q8N885" "Neddylation; KEAP1-NFE2L2 pathway; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex" "" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3246576723643333795" "False" "High" "IsMasterProtein" "Q8N668" "COMM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMMD1 PE=1 SV=1" "0.001" "False" "3.257" "4" "1" "1" "1" "190" "21.2" "6.20" "2.62" "1" "DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07258, Pf17221" "150684" "ENSG00000173163" "COMMD1" "B4DFQ4; hsa:150684; Q8N668; Q96GS0" "Neddylation" "Copper homeostasis; 1p36 copy number variation syndrome" "3" "0" "1.046" "0.887" "1.095" "1.099" "0.939" "0.870" "0.985" "0.937" "0.877" "85.4" "89.3" "75.7" "93.5" "93.8" "80.2" "74.2" "84.0" "79.9" "74.8" "" "" "" "" "" "" "" "" "" "" "77.0" "68.9" "58.6" "62.9" "78.2" "68.4" "63.0" "60.8" "53.9" "74.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3069559242831628546" "False" "High" "IsMasterProtein" "Q7Z460" "CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1" "0.001" "False" "3.255" "1" "1" "1" "1" "1538" "169.3" "9.03" "3.61" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21040" "23332" "ENSG00000074054" "CLASP1" "A2RU21; B7ZLX3; F5GWS0; hsa:23332; O75118; Q2KHQ9; Q5H9P0; Q7Z460; Q8N5B8; Q9BQT5" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Role of ABL in ROBO-SLIT signaling" "Microtubule cytoskeleton regulation; Splicing factor NOVA regulated synaptic proteins; 7q11.23 copy number variation syndrome" "17" "0" "1.007" "0.714" "1.155" "0.984" "0.660" "0.922" "0.905" "0.860" "1.824" "43.4" "43.7" "31.0" "50.1" "42.7" "28.6" "40.0" "39.3" "37.3" "79.2" "" "" "" "" "" "" "" "" "" "" "39.2" "33.7" "24.0" "33.8" "35.7" "24.4" "34.0" "28.4" "25.2" "79.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802052166726839277" "False" "High" "IsMasterProtein" "O75884" "Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2" "0.001" "False" "3.242" "4" "1" "2" "1" "186" "21.0" "6.20" "5.05" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf06821" "10741" "ENSG00000089050" "RBBP9" "D3DW31; hsa:10741; O75884; Q5JPH9; Q9H1D8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350486907516670884" "False" "High" "IsMasterProtein" "Q7Z5K2" "Wings apart-like protein homolog OS=Homo sapiens OX=9606 GN=WAPL PE=1 SV=1" "0.001" "False" "3.240" "2" "2" "2" "2" "1190" "132.9" "5.44" "2.97" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07814" "23063" "ENSG00000062650" "WAPL" "A7E2B5; hsa:23063; Q5VSK5; Q7Z5K2; Q8IX10; Q92549" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5049084120360688973" "False" "High" "IsMasterProtein" "Q6PL24" "Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1" "0.001" "False" "3.239" "5" "2" "2" "2" "325" "35.7" "4.74" "5.44" "2" "" "" "" "Pf13897" "283578" "ENSG00000100580" "TMED8" "B3KTI6; hsa:283578; Q3MJB0; Q6PL24; Q9P1V9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7992266646399474025" "False" "High" "IsMasterProtein" "Q9Y605" "MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1" "0.001" "False" "3.237" "6" "1" "1" "1" "127" "14.6" "4.70" "3.17" "1" "" "nucleus;other cell component" "" "Pf15155" "93621" "ENSG00000179010" "MRFAP1" "B3KVT2; D3DVT3; hsa:93621; Q9Y605" "" "" "0" "0" "0.972" "0.599" "0.999" "0.890" "0.652" "0.823" "0.976" "0.623" "1.017" "131.4" "127.7" "78.6" "131.2" "117.0" "85.6" "108.1" "128.2" "81.9" "133.6" "" "" "" "" "" "" "" "" "" "" "118.6" "98.5" "60.8" "88.4" "97.6" "73.1" "91.7" "92.8" "55.2" "133.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1940772277811891477" "False" "High" "IsMasterProtein" "Q96PM5" "RING finger and CHY zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCHY1 PE=1 SV=1" "0.001" "False" "3.237" "5" "1" "1" "1" "261" "30.1" "6.71" "2.32" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05495, Pf13639, Pf14599" "25898" "ENSG00000163743" "RCHY1" "B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PM5; Q96PR5" "Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH" "Measles virus infection" "3" "0" "0.984" "1.374" "0.829" "0.954" "0.980" "0.873" "1.468" "1.180" "1.059" "25.2" "24.8" "34.6" "20.9" "24.0" "24.7" "22.0" "37.0" "29.7" "26.7" "" "" "" "" "" "" "" "" "" "" "22.7" "19.1" "26.8" "14.1" "20.0" "21.1" "18.7" "26.8" "20.0" "26.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8116747825737560157" "False" "High" "IsMasterProtein" "O15235" "Small ribosomal subunit protein uS12m OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" "0.001" "False" "3.229" "6" "1" "1" "1" "138" "15.2" "10.29" "3.60" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00164" "6183" "ENSG00000128626; ENSG00000283018" "MRPS12" "hsa:6183; O15235; Q53X98" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1890779364620067180" "False" "High" "IsMasterProtein" "Q96CD2" "Phosphopantothenoylcysteine decarboxylase OS=Homo sapiens OX=9606 GN=PPCDC PE=1 SV=2" "0.001" "False" "3.229" "5" "1" "1" "1" "204" "22.4" "6.10" "2.85" "1" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02441" "60490" "ENSG00000138621" "PPCDC" "hsa:60490; Q96CD2; Q96SX0; Q9HC17" "Coenzyme A biosynthesis" "" "1" "0" "0.863" "1.095" "1.113" "1.214" "1.038" "0.778" "0.585" "1.093" "0.709" "30.0" "25.9" "32.8" "33.3" "36.4" "31.1" "23.3" "17.5" "32.8" "21.2" "" "" "" "" "" "" "" "" "" "" "27.1" "20.0" "25.4" "22.5" "30.3" "26.5" "19.8" "12.7" "22.1" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480523710602738279" "False" "High" "IsMasterProtein" "Q9BPZ3" "Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1" "0.001" "False" "3.229" "6" "1" "1" "1" "127" "15.0" "4.12" "3.11" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "51247" "ENSG00000120727" "PAIP2" "B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8" "" "" "0" "0" "0.939" "0.911" "0.927" "0.966" "0.776" "1.011" "1.278" "1.069" "1.224" "131.0" "123.0" "119.4" "121.4" "126.6" "101.6" "132.4" "167.4" "140.0" "160.3" "" "" "" "" "" "" "" "" "" "" "118.2" "94.9" "92.3" "81.8" "105.6" "86.7" "112.3" "121.1" "94.4" "160.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3626479859969264661" "False" "High" "IsMasterProtein" "Q96QG7" "Myotubularin-related protein 9 OS=Homo sapiens OX=9606 GN=MTMR9 PE=1 SV=1" "0.001" "False" "3.225" "1" "1" "2" "1" "549" "63.4" "6.39" "5.06" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf06602, Pf21098" "66036" "ENSG00000104643; ENSG00000285032" "MTMR9" "B7Z291; hsa:66036; Q52LU3; Q8WW11; Q96QG6; Q96QG7; Q9NX50" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "8p23.1 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4498463550983935945" "False" "High" "IsMasterProtein" "Q8NFZ8" "Cell adhesion molecule 4 OS=Homo sapiens OX=9606 GN=CADM4 PE=1 SV=1" "0.001" "False" "3.214" "5" "2" "2" "2" "388" "42.8" "6.30" "5.37" "2" "cell adhesion;other biological processes" "other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07686, Pf08205, Pf13927" "199731" "ENSG00000105767" "CADM4" "B2R7L5; hsa:199731; Q8NFZ8; Q9Y4A4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-11749500110992675" "False" "High" "IsMasterProtein" "Q92995" "Ubiquitin carboxyl-terminal hydrolase 13 OS=Homo sapiens OX=9606 GN=USP13 PE=1 SV=2" "0.001" "False" "3.210" "2" "2" "2" "2" "863" "97.3" "5.53" "4.86" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8975" "ENSG00000058056" "USP13" "A8K2S3; B4DYF3; D3DNS2; hsa:8975; Q92995; Q96B25" "Ub-specific processing proteases; Regulation of PTEN stability and activity" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1368746537246451603" "False" "High" "IsMasterProtein" "Q9Y2I8" "WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2" "0.001" "False" "3.208" "2" "1" "1" "1" "494" "54.6" "7.23" "3.60" "1" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "22884" "ENSG00000047056" "WDR37" "A8K976; D3DRQ7; hsa:22884; Q5SW03; Q8WVG2; Q9NTJ6; Q9Y2I8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431440183355440202" "False" "High" "IsMasterProtein" "Q9ULL5" "Proline-rich protein 12 OS=Homo sapiens OX=9606 GN=PRR12 PE=1 SV=3" "0.001" "False" "3.206" "1" "1" "1" "1" "2036" "210.9" "7.87" "3.50" "1" "" "nucleus;other cell component" "" "Pf13926" "57479" "ENSG00000126464" "PRR12" "E9PB06; hsa:57479; Q8N4J6; Q9ULL5" "" "" "0" "0" "0.943" "1.284" "0.918" "1.100" "0.956" "1.147" "1.013" "1.097" "1.644" "47.1" "44.4" "60.5" "43.2" "51.8" "45.0" "54.0" "47.7" "51.6" "77.4" "" "" "" "" "" "" "" "" "" "" "42.5" "34.3" "46.8" "29.1" "43.2" "38.4" "45.8" "34.5" "34.8" "77.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-510169837627830895" "False" "High" "IsMasterProtein" "P49789" "Bis(5'-adenosyl)-triphosphatase OS=Homo sapiens OX=9606 GN=FHIT PE=1 SV=3" "0.001" "False" "3.206" "14" "2" "2" "2" "147" "16.8" "7.08" "3.10" "2" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01230" "2272" "ENSG00000189283" "FHIT" "A2IAS9; A2IAT0; A2IAT6; A8K1A9; hsa:2272; P49789; Q45QG9; Q6IU12" "" "Non-small cell lung cancer; Small cell lung cancer" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302515266357767192" "False" "High" "IsMasterProtein" "Q9NR46" "Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1" "0.001" "False" "3.205" "2" "1" "1" "1" "395" "43.9" "5.99" "3.01" "1" "cell organization and biogenesis" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03114, Pf14604" "56904" "ENSG00000148341" "SH3GLB2" "A6NC47; A8MPS4; hsa:56904; Q8WY61; Q96JH9; Q9NR46" "" "" "0" "0" "0.751" "0.869" "0.820" "0.911" "0.835" "0.894" "0.602" "0.925" "2.533" "64.9" "48.7" "56.4" "53.2" "59.1" "54.2" "58.0" "39.1" "60.0" "164.5" "" "" "" "" "" "" "" "" "" "" "58.6" "37.6" "43.7" "35.8" "49.3" "46.3" "49.2" "28.3" "40.5" "164.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7190222159830229495" "False" "High" "IsMasterProtein" "Q9H0A0" "RNA cytidine acetyltransferase OS=Homo sapiens OX=9606 GN=NAT10 PE=1 SV=2" "0.001" "False" "3.204" "1" "1" "1" "1" "1025" "115.7" "8.27" "3.40" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05127, Pf08351, Pf13718, Pf13725" "55226" "ENSG00000135372" "NAT10" "B4DFD5; E7ESU4; E9PMN9; hsa:55226; Q86WK5; Q9C0F4; Q9H0A0; Q9HA61; Q9NVF2" "rRNA modification in the nucleus and cytosol" "Metapathway biotransformation Phase I and II" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3216762708121930784" "False" "High" "IsMasterProtein" "Q75N03" "E3 ubiquitin-protein ligase Hakai OS=Homo sapiens OX=9606 GN=CBLL1 PE=1 SV=1" "0.001" "False" "3.202" "2" "1" "1" "1" "491" "54.5" "8.29" "3.32" "1" "cell adhesion;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf18408" "79872" "ENSG00000105879" "CBLL1" "B7ZM03; Q75N03; Q8TAJ4; Q9H5S6" "InlA-mediated entry of Listeria monocytogenes into host cells" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867390860608568122" "False" "High" "IsMasterProtein" "Q9BRJ2" "Large ribosomal subunit protein mL45 OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2" "0.001" "False" "3.201" "5" "2" "3" "2" "306" "35.3" "9.03" "6.56" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf04280" "" "ENSG00000277936" "MRPL45" "A1L436; Q6ZMJ5; Q9BRJ2" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7052799449104643410" "False" "High" "IsMasterProtein" "Q9NUI1" "Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] OS=Homo sapiens OX=9606 GN=DECR2 PE=1 SV=1" "0.001" "False" "3.194" "5" "2" "2" "2" "292" "30.8" "9.22" "3.77" "2" "other metabolic processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf13561" "26063" "ENSG00000242612; ENSG00000274296" "DECR2" "hsa:26063; Q6ZRS7; Q96ET0; Q9NUI1" "Peroxisomal protein import; Beta-oxidation of very long chain fatty acids" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819630258189506626" "False" "High" "IsMasterProtein" "P02792" "Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2" "0.001" "False" "3.191" "9" "1" "1" "1" "175" "20.0" "5.78" "3.21" "1" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2512" "ENSG00000087086" "FTL" "B2R4B9; hsa:2512; P02792; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "9" "0" "0.921" "0.980" "1.106" "1.108" "1.267" "0.863" "0.709" "0.938" "0.895" "24.6" "22.6" "24.1" "27.2" "27.2" "31.1" "21.2" "17.4" "23.1" "22.0" "" "" "" "" "" "" "" "" "" "" "22.2" "17.4" "18.6" "18.3" "22.7" "26.6" "18.0" "12.6" "15.6" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2292593222020041360" "False" "High" "IsMasterProtein" "Q92925" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3" "0.001" "False" "3.188" "2" "1" "1" "1" "531" "58.9" "9.64" "2.51" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02201" "6603" "ENSG00000108604" "SMARCD2" "A5PLL5; A6NNQ7; B4DV56; B4E1R6; hsa:6603; Q7L2I6; Q92925; Q9UHZ1" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8015084779346645449" "False" "High" "IsMasterProtein" "Q8IY34" "Solute carrier family 15 member 3 OS=Homo sapiens OX=9606 GN=SLC15A3 PE=1 SV=2" "0.001" "False" "3.182" "1" "1" "1" "1" "581" "63.5" "9.06" "2.53" "1" "stress response;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "transporter activity" "Pf00854" "51296" "ENSG00000110446" "SLC15A3" "hsa:51296; Q8IY34; Q9P2X9" "Proton/oligopeptide cotransporters" "" "1" "0" "1.009" "1.051" "1.170" "0.947" "1.015" "1.180" "1.213" "1.014" "0.606" "31.6" "31.9" "33.2" "37.0" "29.9" "32.1" "37.3" "38.3" "32.1" "19.2" "" "" "" "" "" "" "" "" "" "" "28.5" "24.6" "25.7" "24.9" "25.0" "27.4" "31.7" "27.7" "21.6" "19.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1379432049065423837" "False" "High" "IsMasterProtein" "O75143" "Autophagy-related protein 13 OS=Homo sapiens OX=9606 GN=ATG13 PE=1 SV=1" "0.001" "False" "3.179" "2" "1" "1" "1" "517" "56.5" "5.12" "2.78" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf10033" "9776" "ENSG00000175224" "ATG13" "B4DFI4; D3DQQ1; D3DQQ2; E9PQZ8; hsa:9776; O75143; Q53EN6; Q9BRL3; Q9H8B0" "Macroautophagy" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "12" "0" "1.115" "0.969" "0.924" "0.805" "0.902" "0.927" "0.976" "0.856" "1.094" "52.4" "58.5" "50.8" "48.5" "42.2" "47.3" "48.6" "51.2" "44.9" "57.4" "" "" "" "" "" "" "" "" "" "" "47.3" "45.1" "39.3" "32.6" "35.2" "40.4" "41.3" "37.1" "30.3" "57.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909232235632679983" "False" "High" "IsMasterProtein" "Q13418" "Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2" "0.001" "False" "3.179" "2" "1" "1" "1" "452" "51.4" "8.07" "3.05" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf07714, Pf12796" "3611" "ENSG00000166333" "ILK" "B7Z1I0; B7Z418; D3DQU0; hsa:3611; P57043; Q13418; Q68DZ3" "Localization of the PINCH-ILK-PARVIN complex to focal adhesions" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system; 2q37 copy number variation syndrome" "13" "0" "0.991" "0.785" "1.056" "1.020" "0.670" "0.912" "0.972" "0.757" "1.529" "115.4" "114.3" "90.6" "121.9" "117.8" "77.4" "105.3" "112.2" "87.3" "176.5" "" "" "" "" "" "" "" "" "" "" "104.2" "88.2" "70.0" "82.1" "98.3" "66.0" "89.3" "81.2" "58.9" "176.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014625147701874173" "False" "High" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "0.001" "False" "3.179" "1" "1" "1" "1" "578" "65.5" "8.21" "3.05" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.037" "0.948" "1.059" "1.124" "0.759" "1.356" "1.238" "0.801" "0.839" "86.9" "90.2" "82.4" "92.1" "97.7" "66.0" "117.9" "107.6" "69.6" "73.0" "" "" "" "" "" "" "" "" "" "" "78.5" "69.5" "63.7" "62.0" "81.5" "56.3" "100.0" "77.9" "47.0" "73.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928347610324358029" "False" "High" "IsMasterProtein" "Q9HAP6" "Protein lin-7 homolog B OS=Homo sapiens OX=9606 GN=LIN7B PE=1 SV=1" "0.001" "False" "3.172" "5" "1" "1" "1" "207" "22.9" "8.66" "3.57" "1" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00595, Pf02828" "64130" "ENSG00000104863" "LIN7B" "hsa:64130; Q9HAP6" "Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; RHO GTPases Activate Rhotekin and Rhophilins" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294747431044223143" "False" "High" "IsMasterProtein" "Q9UBN7" "Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2" "0.001" "False" "3.171" "1" "1" "1" "1" "1215" "131.3" "5.30" "2.55" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00850, Pf02148" "10013" "ENSG00000094631" "HDAC6" "hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7" "Cilium Assembly; Aggrephagy; Late endosomal microautophagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Transcriptional regulation by RUNX2; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "17" "0" "0.999" "0.605" "1.039" "0.900" "0.947" "0.905" "0.926" "0.898" "1.117" "33.5" "33.5" "20.3" "34.8" "30.2" "31.7" "30.3" "31.0" "30.1" "37.4" "" "" "" "" "" "" "" "" "" "" "30.2" "25.8" "15.7" "23.4" "25.2" "27.1" "25.7" "22.5" "20.3" "37.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8102518268723220557" "False" "High" "IsMasterProtein" "Q2M2I8" "AP2-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=AAK1 PE=1 SV=3" "0.001" "False" "3.169" "1" "1" "1" "1" "961" "103.8" "6.60" "3.18" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "22848" "ENSG00000115977" "AAK1" "hsa:22848; Q2M2I8; Q4ZFZ3; Q53RX6; Q9UPV4" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "0.918" "0.780" "0.735" "1.128" "1.075" "1.133" "1.037" "0.772" "0.896" "36.3" "33.3" "28.3" "26.7" "40.9" "39.0" "41.1" "37.6" "28.0" "32.5" "" "" "" "" "" "" "" "" "" "" "32.8" "25.7" "21.9" "18.0" "34.1" "33.3" "34.9" "27.2" "18.9" "32.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084351700158867792" "False" "High" "IsMasterProtein" "Q9HD33" "Large ribosomal subunit protein uL29m OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" "0.001" "False" "3.162" "3" "1" "1" "1" "250" "29.4" "10.37" "2.97" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf06984" "57129" "ENSG00000136522" "MRPL47" "hsa:57129; Q6XRG1; Q8N5D1; Q9HD33" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.092" "0.883" "1.093" "0.948" "0.857" "0.956" "0.943" "0.900" "0.912" "92.0" "100.5" "81.2" "100.6" "87.2" "78.8" "88.0" "86.8" "82.8" "83.9" "" "" "" "" "" "" "" "" "" "" "83.1" "77.5" "62.8" "67.7" "72.7" "67.3" "74.6" "62.8" "55.9" "83.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1389983804562693885" "False" "High" "IsMasterProtein" "A2RUC4" "tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1" "0.001" "False" "3.155" "5" "2" "2" "2" "315" "36.5" "7.55" "0.00" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf13621" "129450" "ENSG00000162971" "TYW5" "A2RUC4; B2RNE3; hsa:129450; Q8N1R2" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1687384969150092260" "False" "High" "IsMasterProtein" "Q96B97" "SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2" "0.001" "False" "3.150" "2" "1" "1" "1" "665" "73.1" "6.62" "3.34" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14604" "30011" "ENSG00000147010" "SH3KBP1" "B7Z1D5; hsa:30011; Q5JPT4; Q5JPT5; Q8IWX6; Q8IX98; Q96B97; Q96RN4; Q9NYR0" "Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Reelin signalling pathway" "EGF/EGFR signaling pathway" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2809797377402095157" "False" "High" "IsMasterProtein" "P42785" "Lysosomal Pro-X carboxypeptidase OS=Homo sapiens OX=9606 GN=PRCP PE=1 SV=1" "0.001" "False" "3.146" "2" "1" "1" "1" "496" "55.8" "7.21" "2.81" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "5547" "ENSG00000137509" "PRCP" "A8MU24; B2R7B7; B3KRK5; B5BU34; hsa:5547; P42785" "Neutrophil degranulation; Intrinsic Pathway of Fibrin Clot Formation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5381217781487520932" "False" "High" "IsMasterProtein" "Q99536" "Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2" "0.001" "False" "3.146" "4" "1" "1" "1" "393" "41.9" "6.29" "0.00" "1" "other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf08240, Pf13602" "10493" "ENSG00000108828" "VAT1" "A8K345; B0AZP7; B4DPX4; hsa:10493; Q13035; Q5BKZ7; Q96A39; Q99536; Q9BUT8" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849479475208291816" "False" "High" "IsMasterProtein" "Q9H8Y5" "tRNA endonuclease ANKZF1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1" "0.001" "False" "3.144" "2" "1" "1" "1" "726" "80.9" "8.41" "2.28" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other cell component" "other molecular function" "Pf00023, Pf18716, Pf18826" "55139" "ENSG00000163516" "ANKZF1" "hsa:55139; Q9H8Y5; Q9NVZ4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6553541234872075133" "False" "High" "IsMasterProtein" "Q8N488" "RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2" "0.001" "False" "3.143" "7" "2" "2" "1" "228" "24.8" "9.63" "6.73" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "23429" "ENSG00000163602; ENSG00000281766" "RYBP" "hsa:23429; Q8N488; Q9P2W5; Q9UMW4" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "" "2" "0" "1.003" "0.978" "0.916" "0.935" "1.099" "0.880" "0.882" "1.039" "0.991" "128.8" "129.2" "125.9" "118.1" "120.5" "141.6" "113.3" "113.7" "133.8" "127.7" "" "" "" "" "" "" "" "" "" "" "116.3" "99.6" "97.4" "79.5" "100.5" "120.9" "96.1" "82.2" "90.3" "127.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667791429140774240" "False" "High" "IsMasterProtein" "Q9NUM4" "Transmembrane protein 106B OS=Homo sapiens OX=9606 GN=TMEM106B PE=1 SV=2" "0.001" "False" "3.141" "3" "1" "1" "1" "274" "31.1" "6.99" "2.88" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf07092, Pf21002" "54664" "ENSG00000106460" "TMEM106B" "A4D108; hsa:54664; Q53FL9; Q8N4L0; Q9NUM4" "" "" "0" "0" "0.982" "1.138" "1.015" "0.902" "1.042" "1.025" "1.093" "1.143" "0.675" "156.6" "153.8" "178.2" "159.0" "141.2" "163.1" "160.6" "171.1" "179.0" "105.7" "" "" "" "" "" "" "" "" "" "" "141.3" "118.6" "137.8" "107.1" "117.8" "139.2" "136.2" "123.8" "120.7" "105.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8001945499400243229" "False" "High" "IsMasterProtein" "Q99519" "Sialidase-1 OS=Homo sapiens OX=9606 GN=NEU1 PE=1 SV=1" "0.001" "False" "3.138" "2" "1" "1" "1" "415" "45.4" "5.88" "2.56" "1" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13088" "4758" "ENSG00000184494; ENSG00000204386; ENSG00000223957; ENSG00000227129; ENSG00000227315; ENSG00000228691; ENSG00000234343; ENSG00000234846" "NEU1" "hsa:4758; Q99519" "Neutrophil degranulation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721253402515192355" "False" "High" "IsMasterProtein" "O95544" "NAD kinase OS=Homo sapiens OX=9606 GN=NADK PE=1 SV=1" "0.001" "False" "3.130" "3" "1" "1" "1" "446" "49.2" "6.47" "2.05" "1" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01513, Pf20143" "65220" "ENSG00000008130" "NADK" "A6NNN3; A8K296; B7Z434; F5GXR5; hsa:65220; O95544; Q5QPS4; Q9H2P2; Q9H931" "Nicotinate metabolism" "NAD+ metabolism; 1p36 copy number variation syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1612491288449717862" "False" "High" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "0.001" "False" "3.123" "3" "1" "1" "1" "320" "35.3" "8.22" "2.98" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00043, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2347983332977388865" "False" "High" "IsMasterProtein" "Q9H900" "Protein zwilch homolog OS=Homo sapiens OX=9606 GN=ZWILCH PE=1 SV=2" "0.001" "False" "3.123" "1" "1" "1" "1" "591" "67.2" "6.27" "3.35" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf09817" "55055" "ENSG00000174442" "ZWILCH" "B3KVB8; hsa:55055; Q6N049; Q8N404; Q96SY7; Q9H900; Q9NWG7" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3820767575237366491" "False" "High" "IsMasterProtein" "Q9HAU5" "Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1" "0.001" "False" "3.118" "1" "2" "2" "2" "1272" "147.7" "5.69" "5.46" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02854, Pf04050" "26019" "ENSG00000151461" "UPF2" "A6NLJ5; D3DRS0; hsa:26019; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9HAU5; Q9NWL1; Q9P2D9; Q9Y4M9" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397920079809031089" "False" "High" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "0.001" "False" "3.116" "1" "1" "1" "1" "666" "73.1" "5.59" "3.12" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "TYROBP causal network in microglia" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6857356928160301149" "False" "High" "IsMasterProtein" "Q9C0E8" "Endoplasmic reticulum junction formation protein lunapark OS=Homo sapiens OX=9606 GN=LNPK PE=1 SV=2" "0.001" "False" "3.115" "3" "1" "1" "1" "428" "47.7" "5.11" "3.63" "1" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf10058" "80856" "ENSG00000144320" "LNPK" "B7ZLA8; hsa:80856; Q2M2V8; Q2YD99; Q658W8; Q8N5V9; Q96MS5; Q9C0E8" "" "" "0" "0" "1.009" "0.909" "0.761" "1.068" "1.050" "0.977" "0.958" "0.906" "0.668" "92.4" "93.2" "84.0" "70.4" "98.7" "97.0" "90.2" "88.5" "83.7" "61.7" "" "" "" "" "" "" "" "" "" "" "83.4" "71.9" "64.9" "47.4" "82.3" "82.8" "76.5" "64.0" "56.5" "61.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624029487017367107" "False" "High" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "0.001" "False" "3.109" "9" "1" "1" "1" "99" "11.2" "4.88" "3.43" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "Kleefstra syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625038226073765913" "False" "High" "IsMasterProtein" "P61421" "V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1" "0.001" "False" "3.102" "2" "1" "1" "1" "351" "40.3" "5.00" "3.35" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01992" "9114" "ENSG00000159720" "ATP6V0D1" "hsa:9114; P12953; P61421; Q02547" "Amino acids regulate mTORC1; XBP1(S) activates chaperone genes; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "VEGFA-VEGFR2 signaling" "7" "0" "0.982" "1.110" "1.160" "1.154" "1.011" "1.010" "1.077" "1.238" "1.611" "152.8" "150.0" "169.7" "177.2" "176.4" "154.5" "154.4" "164.5" "189.3" "246.3" "" "" "" "" "" "" "" "" "" "" "138.0" "115.7" "131.2" "119.4" "147.1" "131.9" "131.0" "119.1" "127.7" "246.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5221985020490519737" "False" "High" "IsMasterProtein" "Q6PJI9" "GATOR2 complex protein WDR59 OS=Homo sapiens OX=9606 GN=WDR59 PE=1 SV=2" "0.001" "False" "3.099" "1" "1" "1" "1" "974" "109.7" "7.91" "3.19" "1" "stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf17120" "79726" "ENSG00000103091" "WDR59" "B3KRC3; hsa:79726; Q6PJI9; Q71RE7; Q96PW5; Q9BSW6; Q9HA43" "Amino acids regulate mTORC1" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225180490638560304" "False" "High" "IsMasterProtein" "P51157" "Ras-related protein Rab-28 OS=Homo sapiens OX=9606 GN=RAB28 PE=1 SV=2" "0.001" "False" "3.091" "4" "1" "1" "1" "221" "24.8" "5.97" "3.28" "1" "transport" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00071" "9364" "ENSG00000157869" "RAB28" "G8JLC5; hsa:9364; P51157; Q8IYR8; Q8NI05" "" "Ciliopathies" "1" "0" "1.102" "0.947" "1.262" "1.172" "0.900" "1.190" "1.054" "0.817" "1.203" "94.1" "103.7" "89.1" "118.8" "110.3" "84.7" "111.9" "99.2" "76.8" "113.2" "" "" "" "" "" "" "" "" "" "" "84.9" "80.0" "68.9" "80.0" "92.0" "72.3" "95.0" "71.8" "51.8" "113.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516330367870273472" "False" "High" "IsMasterProtein" "P09086" "POU domain, class 2, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU2F2 PE=1 SV=3" "0.001" "False" "3.085" "2" "1" "2" "1" "479" "51.2" "8.43" "6.44" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "5452" "ENSG00000028277" "POU2F2" "hsa:5452; P09086; Q16648; Q7M4M8; Q9BRS4" "RNA polymerase II transcribes snRNA genes" "Ectoderm differentiation; Prion disease pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "4" "0" "1.103" "1.341" "1.147" "1.133" "1.361" "1.304" "0.699" "1.604" "10.357" "42.4" "46.7" "56.8" "48.6" "48.0" "57.7" "55.3" "29.6" "68.0" "438.9" "" "" "" "" "" "" "" "" "" "" "38.3" "36.0" "44.0" "32.7" "40.1" "49.2" "46.9" "21.5" "45.8" "438.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1961832364316848105" "False" "High" "IsMasterProtein" "Q9NVM4" "Protein arginine N-methyltransferase 7 OS=Homo sapiens OX=9606 GN=PRMT7 PE=1 SV=1" "0.001" "False" "3.073" "2" "2" "2" "2" "692" "78.4" "5.57" "5.03" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf06325" "54496" "ENSG00000132600" "PRMT7" "B3KPR0; B3KUG9; B4E379; hsa:54496; Q96PV5; Q9H9L0; Q9NVM4" "RMTs methylate histone arginines" "Nitric oxide metabolism in cystic fibrosis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3008882847524475916" "False" "High" "IsMasterProtein" "Q15041" "ADP-ribosylation factor-like protein 6-interacting protein 1 OS=Homo sapiens OX=9606 GN=ARL6IP1 PE=1 SV=2" "0.001" "False" "3.073" "4" "1" "1" "1" "203" "23.3" "9.32" "3.40" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "" "23204" "ENSG00000170540" "ARL6IP1" "B7Z6S5; B7Z791; F5GXP4; hsa:23204; Q15041" "" "" "0" "0" "0.897" "0.664" "0.898" "0.851" "0.578" "0.890" "0.946" "0.594" "0.550" "232.6" "208.6" "154.4" "208.8" "197.9" "134.4" "207.1" "220.0" "138.2" "127.9" "" "" "" "" "" "" "" "" "" "" "210.0" "160.9" "119.4" "140.6" "165.1" "114.7" "175.7" "159.2" "93.2" "127.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9088787272925242729" "False" "High" "IsMasterProtein" "Q9C0D3" "Protein zyg-11 homolog B OS=Homo sapiens OX=9606 GN=ZYG11B PE=1 SV=2" "0.001" "False" "3.068" "3" "1" "1" "1" "744" "83.9" "6.86" "2.25" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "79699" "ENSG00000162378" "ZYG11B" "hsa:79699; Q8N2X3; Q9C0D3; Q9H8L8" "" "Ciliary landscape; Hijack of ubiquitination by SARS-CoV-2" "2" "0" "1.253" "1.566" "1.373" "1.444" "1.347" "1.036" "1.064" "1.473" "0.604" "41.4" "51.9" "64.9" "56.9" "59.8" "55.8" "42.9" "44.1" "61.0" "25.0" "" "" "" "" "" "" "" "" "" "" "37.4" "40.1" "50.2" "38.3" "49.9" "47.6" "36.4" "31.9" "41.2" "25.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1707111681236337832" "False" "High" "IsMasterProtein" "Q96BY7" "Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5" "0.001" "False" "3.067" "1" "2" "2" "2" "2078" "232.6" "5.76" "4.26" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624, Pf13329" "55102" "ENSG00000066739" "ATG2B" "hsa:55102; Q6ZRE7; Q96BY7; Q96DQ3; Q9NW80" "" "Alzheimer's disease and miRNA effects; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Alzheimer's disease" "3" "0" "1.088" "1.015" "1.153" "1.213" "0.922" "0.934" "1.147" "0.982" "0.918" "87.2" "94.9" "88.6" "100.6" "105.8" "80.5" "81.4" "100.1" "85.6" "80.1" "" "" "" "" "" "" "" "" "" "" "78.7" "73.2" "68.5" "67.8" "88.3" "68.7" "69.1" "72.4" "57.8" "80.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7152432727454643144" "False" "High" "IsMasterProtein" "Q6PII3" "Coiled-coil domain-containing protein 174 OS=Homo sapiens OX=9606 GN=CCDC174 PE=1 SV=3" "0.001" "False" "3.065" "2" "1" "1" "1" "467" "53.9" "6.33" "2.80" "1" "" "nucleus" "" "Pf13300" "51244" "ENSG00000154781" "CCDC174" "hsa:51244; Q6PII3; Q96CS5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926679715344885449" "False" "High" "IsMasterProtein" "O94913" "Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3" "0.001" "False" "3.056" "1" "2" "2" "2" "1555" "172.9" "8.48" "4.48" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04818, Pf11526, Pf20827, Pf20844, Pf20845" "51585" "ENSG00000165494" "PCF11" "A6H8W7; hsa:51585; O43671; O94913; Q6P0X8" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991107467839093977" "False" "High" "IsMasterProtein" "Q99747" "Gamma-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPG PE=1 SV=1" "0.001" "False" "3.053" "3" "1" "1" "1" "312" "34.7" "5.41" "2.00" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf14938" "8774" "ENSG00000134265" "NAPG" "B4DFC9; hsa:8774; Q99747; Q9BUV1" "COPII-mediated vesicle transport; COPI-mediated anterograde transport; Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; Intra-Golgi traffic" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3693927105284752226" "False" "High" "IsMasterProtein" "Cont_Q3ZBS7" "Vitronectin OS=Bos taurus OX=9913 GN=VTN PE=1 SV=1" "0.001" "True" "3.052" "3" "1" "1" "1" "476" "53.5" "6.28" "2.00" "1" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00045, Pf01033" "507525" "ENSBIXG00000028629; ENSBTAG00000016151" "VTN" "A0A4W2E672; bta:507525; Q3ZBS7" "Integrin cell surface interactions; ECM proteoglycans; Molecules associated with elastic fibres; Syndecan interactions; Regulation of Complement cascade" "Inflammatory response pathway; Focal adhesion; Primary focal segmental glomerulosclerosis (FSGS)" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3191297454369684242" "False" "High" "IsMasterProtein" "Q8WZ42" "Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4" "0.001" "False" "3.051" "0" "2" "2" "2" "34350" "3813.7" "6.35" "4.87" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;kinase activity;other molecular function" "Pf00041, Pf00069, Pf02818, Pf07679, Pf09042, Pf18362" "7273" "ENSG00000155657" "TTN" "A6NKB1; E7EQE6; E7ET18; hsa:7273; K7ENY1; Q10465; Q10466; Q15598; Q2XUS3; Q32Q60; Q4U1Z6; Q4ZG20; Q6NSG0; Q6PDB1; Q6PJP0; Q7KYM2; Q7KYN4; Q7KYN5; Q7LDM3; Q7Z2X3; Q8TCG8; Q8WZ42; Q8WZ51; Q8WZ52; Q8WZ53; Q8WZB3; Q92761; Q92762; Q9UD97; Q9UP84; Q9Y6L9" "Platelet degranulation ; Striated Muscle Contraction" "Striated muscle contraction pathway; Cardiomyocyte signaling pathways converging on titin" "4" "0" "0.533" "0.697" "0.782" "0.574" "0.676" "0.549" "0.639" "0.593" "0.624" "234.6" "125.0" "163.4" "183.4" "134.6" "158.5" "128.8" "149.8" "139.2" "146.4" "" "" "" "" "" "" "" "" "" "" "211.8" "96.4" "126.4" "123.5" "112.3" "135.3" "109.3" "108.4" "93.9" "146.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6322576459719566173" "False" "High" "IsMasterProtein" "Cont_P02754" "Beta-lactoglobulin OS=Bos taurus OX=9913 GN=LGB PE=1 SV=3" "0.001" "True" "3.047" "6" "1" "1" "1" "178" "19.9" "5.02" "2.04" "1" "" "non-structural extracellular" "other molecular function" "Pf00061" "280838" "ENSBIXG00000010604; ENSBIXG00005010722; ENSBTAG00000014678" "LGB; LOC113901792" "A0A4W2BVI6; bta:280838; P02754; Q32P89" "" "" "0" "0" "1.070" "1.499" "1.180" "0.956" "1.087" "0.961" "1.090" "1.184" "0.882" "45.3" "48.5" "67.9" "53.5" "43.3" "49.2" "43.5" "49.4" "53.6" "40.0" "" "" "" "" "" "" "" "" "" "" "40.9" "37.4" "52.5" "36.0" "36.1" "42.0" "36.9" "35.7" "36.2" "40.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3231455898363948540" "False" "High" "IsMasterProtein" "Q15833" "Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2" "0.001" "False" "3.046" "2" "1" "1" "1" "593" "66.4" "6.55" "2.40" "1" "cell-cell signaling;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "6813" "ENSG00000076944" "STXBP2" "B4E175; E7EQD5; hsa:6813; Q15833; Q9BU65" "Platelet degranulation ; Other interleukin signaling" "Splicing factor NOVA regulated synaptic proteins; Insulin signaling" "4" "0" "0.655" "0.915" "0.567" "0.765" "0.777" "0.859" "0.675" "0.624" "1.894" "146.1" "95.6" "133.7" "82.9" "111.8" "113.6" "125.5" "98.6" "91.1" "276.8" "" "" "" "" "" "" "" "" "" "" "131.9" "73.8" "103.4" "55.8" "93.2" "97.0" "106.4" "71.4" "61.5" "276.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5495353831656127209" "False" "High" "IsMasterProtein" "Q8ND04" "Nonsense-mediated mRNA decay factor SMG8 OS=Homo sapiens OX=9606 GN=SMG8 PE=1 SV=1" "0.001" "False" "3.045" "1" "1" "1" "1" "991" "109.6" "7.68" "2.57" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol" "" "Pf10220" "55181" "ENSG00000167447" "SMG8" "hsa:55181; Q8N5U5; Q8ND04; Q8TDN0; Q9H5P5; Q9NVQ1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "" "1" "0" "1.007" "1.276" "1.125" "1.024" "1.035" "0.862" "0.910" "1.064" "5.528" "23.7" "23.8" "30.2" "26.6" "24.2" "24.5" "20.4" "21.5" "25.2" "130.8" "" "" "" "" "" "" "" "" "" "" "21.4" "18.4" "23.3" "17.9" "20.2" "20.9" "17.3" "15.6" "17.0" "130.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5225742282828706661" "False" "High" "IsMasterProtein" "Q8NDH2" "Leucine-rich repeat transmembrane protein CCDC168 OS=Homo sapiens OX=9606 GN=CCDC168 PE=1 SV=3" "0.001" "False" "3.032" "0" "2" "2" "1" "7081" "801.4" "8.79" "2.60" "2" "" "other membranes" "" "Pf15804" "643677" "ENSG00000175820" "CCDC168" "hsa:643677; Q8N800; Q8NDH2" "" "" "0" "0" "0.919" "0.897" "0.663" "0.881" "0.845" "0.789" "1.027" "0.999" "0.796" "131.4" "120.8" "117.9" "87.2" "115.8" "111.1" "103.7" "134.9" "131.3" "104.7" "" "" "" "" "" "" "" "" "" "" "118.6" "93.2" "91.2" "58.7" "96.6" "94.8" "88.0" "97.7" "88.5" "104.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5006155018502035980" "False" "High" "IsMasterProtein" "Q8WXI2" "Connector enhancer of kinase suppressor of ras 2 OS=Homo sapiens OX=9606 GN=CNKSR2 PE=1 SV=1" "0.001" "False" "3.028" "1" "1" "2" "1" "1034" "117.5" "6.79" "2.16" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00169, Pf00536, Pf00595, Pf06663, Pf10534" "22866" "ENSG00000149970" "CNKSR2" "B4DGR4; B7ZLJ1; B9EG83; E7ESA4; hsa:22866; O94976; Q5JPK4; Q5JPN0; Q8WXI1; Q8WXI2" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "" "7" "0" "0.697" "0.928" "0.948" "0.832" "0.944" "0.949" "1.009" "0.838" "0.655" "281.4" "196.2" "261.0" "266.7" "234.2" "265.5" "267.0" "284.0" "235.8" "184.3" "" "" "" "" "" "" "" "" "" "" "254.0" "151.3" "201.9" "179.6" "195.4" "226.6" "226.5" "205.6" "159.0" "184.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3247337186477247949" "False" "High" "IsMasterProtein" "Q9UQR1" "Zinc finger protein 148 OS=Homo sapiens OX=9606 GN=ZNF148 PE=1 SV=2" "0.001" "False" "3.028" "1" "1" "2" "1" "794" "88.9" "6.48" "0.00" "1" "stress response;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7707" "ENSG00000163848" "ZNF148" "D3DN27; O00389; O43591; Q58EY5; Q6PJ98; Q9UQR1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "336772770148819757" "False" "High" "IsMasterProtein" "Q9NVR0" "Kelch-like protein 11 OS=Homo sapiens OX=9606 GN=KLHL11 PE=1 SV=1" "0.001" "False" "3.027" "2" "1" "1" "1" "708" "80.1" "6.16" "2.29" "1" "" "cytosol" "" "Pf00651, Pf01344, Pf07707" "55175" "ENSG00000178502" "KLHL11" "hsa:55175; Q9NVR0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.167" "0.964" "1.169" "0.918" "0.706" "0.951" "0.975" "1.110" "1.037" "47.2" "55.1" "45.5" "55.2" "43.4" "33.4" "44.9" "46.1" "52.4" "49.0" "" "" "" "" "" "" "" "" "" "" "42.6" "42.5" "35.2" "37.2" "36.2" "28.5" "38.1" "33.3" "35.4" "49.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318152306764108447" "False" "High" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "0.001" "False" "3.021" "1" "1" "2" "1" "726" "80.6" "8.78" "6.06" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "17" "0" "0.965" "1.047" "0.986" "1.060" "0.955" "0.931" "0.979" "1.030" "1.373" "118.5" "114.3" "124.0" "116.8" "125.6" "113.2" "110.3" "116.0" "122.0" "162.7" "" "" "" "" "" "" "" "" "" "" "106.9" "88.2" "95.9" "78.6" "104.7" "96.6" "93.6" "83.9" "82.3" "162.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626058579617190840" "False" "High" "IsMasterProtein" "Q5VYS8" "Terminal uridylyltransferase 7 OS=Homo sapiens OX=9606 GN=TUT7 PE=1 SV=1" "0.001" "False" "3.020" "1" "1" "1" "1" "1495" "171.1" "6.83" "3.24" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf03828, Pf16631, Pf19088" "79670" "ENSG00000083223" "TUT7" "hsa:79670; Q5H9T0; Q5VYS5; Q5VYS7; Q5VYS8; Q658Z9; Q659A2; Q6MZJ3; Q8N5F0; Q96N57; Q96NE8; Q9C0F2; Q9H8M6" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "" "3" "0" "0.937" "1.180" "0.834" "1.057" "1.041" "0.905" "1.138" "1.056" "1.919" "57.7" "54.0" "68.0" "48.1" "60.9" "60.0" "52.2" "65.6" "60.9" "110.7" "" "" "" "" "" "" "" "" "" "" "52.0" "41.7" "52.6" "32.4" "50.8" "51.2" "44.3" "47.5" "41.1" "110.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4884544168886034419" "False" "High" "IsMasterProtein" "Q9NV92" "NEDD4 family-interacting protein 2 OS=Homo sapiens OX=9606 GN=NDFIP2 PE=1 SV=2" "0.001" "False" "3.016" "3" "1" "1" "1" "336" "36.4" "5.08" "3.14" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "54602" "ENSG00000102471" "NDFIP2" "hsa:54602; Q7Z2H3; Q7Z428; Q8TAR3; Q9NV92; Q9ULQ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8417235359346522376" "False" "High" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "0.001" "False" "3.015" "2" "1" "1" "1" "457" "49.8" "8.41" "3.01" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "RET signaling" "Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation" "4" "0" "1.054" "0.958" "1.125" "1.032" "0.971" "1.088" "1.139" "1.151" "1.386" "110.9" "116.8" "106.2" "124.7" "114.4" "107.6" "120.6" "126.3" "127.6" "153.6" "" "" "" "" "" "" "" "" "" "" "100.1" "90.1" "82.2" "84.0" "95.4" "91.9" "102.3" "91.4" "86.0" "153.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714801153834532541" "False" "High" "IsMasterProtein" "O14733" "Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2" "0.001" "False" "3.013" "2" "1" "1" "1" "419" "47.5" "9.16" "3.53" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5609" "ENSG00000076984" "MAP2K7" "B2R9S5; D6W659; hsa:5609; O14648; O14733; O14816; O60452; O60453; Q1PG43; Q8IY10" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "28" "0" "0.946" "0.818" "1.240" "1.019" "0.805" "1.129" "1.148" "0.761" "1.124" "75.7" "71.6" "61.9" "93.8" "77.1" "60.9" "85.4" "86.8" "57.6" "85.0" "" "" "" "" "" "" "" "" "" "" "68.3" "55.2" "47.8" "63.2" "64.3" "52.0" "72.5" "62.9" "38.8" "85.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8718473415120973367" "False" "High" "IsMasterProtein" "O00462" "Beta-mannosidase OS=Homo sapiens OX=9606 GN=MANBA PE=1 SV=3" "0.001" "False" "3.007" "2" "2" "3" "1" "879" "100.8" "5.52" "6.56" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf02836, Pf17753, Pf17786" "4126" "ENSG00000109323" "MANBA" "hsa:4126; O00462; Q96BC3; Q9NYX9" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8382975367682905247" "False" "High" "IsMasterProtein" "Q8N819" "Probable protein phosphatase 1N OS=Homo sapiens OX=9606 GN=PPM1N PE=2 SV=2" "0.001" "False" "3.006" "2" "1" "2" "1" "430" "46.1" "6.62" "4.44" "1" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "147699" "ENSG00000213889" "PPM1N" "hsa:147699; Q6P662; Q8N819" "" "" "0" "0" "0.908" "1.016" "1.060" "0.974" "1.104" "1.034" "0.917" "0.905" "0.768" "78.6" "71.3" "79.8" "83.2" "76.5" "86.7" "81.2" "72.0" "71.1" "60.4" "" "" "" "" "" "" "" "" "" "" "70.9" "55.0" "61.7" "56.0" "63.8" "74.0" "68.9" "52.1" "47.9" "60.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054599493317546199" "False" "High" "IsMasterProtein" "Q8TCC3" "Large ribosomal subunit protein uL30m OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1" "0.001" "False" "3.005" "7" "1" "1" "1" "161" "18.5" "9.99" "2.83" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00327" "51263" "ENSG00000185414" "MRPL30" "A6NIC6; D3DVI0; D3DVI3; hsa:51263; Q0D2Q7; Q6ZTP4; Q8TCC3; Q96Q69; Q9P0N0" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7572022130176331113" "False" "High" "IsMasterProtein" "Q9H840" "Gem-associated protein 7 OS=Homo sapiens OX=9606 GN=GEMIN7 PE=1 SV=1" "0.002" "False" "2.998" "11" "2" "2" "2" "131" "14.5" "7.40" "5.36" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf11095" "79760" "ENSG00000142252" "GEMIN7" "hsa:79760; Q6IA34; Q9H840" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "" "2" "0" "0.987" "0.943" "1.187" "1.046" "0.946" "1.071" "0.986" "1.003" "1.025" "156.2" "154.2" "147.3" "185.4" "163.5" "147.8" "167.3" "154.1" "156.8" "160.2" "" "" "" "" "" "" "" "" "" "" "141.0" "118.9" "113.9" "124.9" "136.4" "126.1" "141.9" "111.5" "105.7" "160.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8502957251701712576" "False" "High" "IsMasterProtein" "Q9UHW5" "GPN-loop GTPase 3 OS=Homo sapiens OX=9606 GN=GPN3 PE=1 SV=2" "0.002" "False" "2.996" "5" "1" "1" "1" "284" "32.7" "4.50" "2.28" "1" "" "other cell component" "other molecular function" "Pf03029" "51184" "ENSG00000111231" "GPN3" "B2RC54; D4YWV1; F5H759; hsa:51184; Q53FS3; Q6UVZ6; Q7Z3D3; Q8NEI2; Q96HK9; Q9UHW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "5771455182534441899" "False" "High" "IsMasterProtein" "P11137" "Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4" "0.002" "False" "2.995" "0" "1" "1" "1" "1827" "199.4" "4.91" "2.89" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418, Pf08377" "4133" "ENSG00000078018" "MAP2" "hsa:4133; P11137; Q17S04; Q8IUX2; Q99975; Q99976" "" "Melatonin metabolism and effects; MAPK cascade; Neurogenesis regulation in the olfactory epithelium; Cell lineage map for neuronal differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3817415269467879151" "False" "High" "IsMasterProtein" "P16435" "NADPH--cytochrome P450 reductase OS=Homo sapiens OX=9606 GN=POR PE=1 SV=2" "0.002" "False" "2.993" "1" "1" "1" "1" "677" "76.6" "5.58" "3.02" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "5447" "ENSG00000127948" "POR" "P16435; Q16455; Q197M5; Q8N181; Q9H3M8; Q9UDT3" "Cytochrome P450 - arranged by substrate type" "Oxidation by cytochrome P450; Ferroptosis; 7q11.23 distal copy number variation" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397574204075436679" "False" "High" "IsMasterProtein" "Q15013" "MAD2L1-binding protein OS=Homo sapiens OX=9606 GN=MAD2L1BP PE=1 SV=1" "0.002" "False" "2.984" "3" "1" "1" "1" "274" "31.0" "6.30" "3.18" "1" "other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06581" "9587" "ENSG00000124688" "MAD2L1BP" "B4DLV3; E9PAT7; hsa:9587; Q15013; Q6IBB1" "" "3q29 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3045251361027418727" "False" "High" "IsMasterProtein" "O43237" "Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1" "0.002" "False" "2.979" "2" "1" "1" "1" "492" "54.1" "6.38" "1.89" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "1783" "ENSG00000135720" "DYNC1LI2" "A8K6V1; B4DZP4; hsa:1783; O43237; Q8TAT3" "HCMV Early Events; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660217191297362812" "False" "High" "IsMasterProtein" "P22695" "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3" "0.002" "False" "2.976" "3" "1" "1" "1" "453" "48.4" "8.63" "2.19" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00675, Pf05193" "7385" "ENSG00000140740" "UQCRC2" "B3KSN4; hsa:7385; P22695; Q9BQ05" "Mitochondrial protein degradation; Respiratory electron transport" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1582379708975939504" "False" "High" "IsMasterProtein" "Q6V1P9" "Protocadherin-23 OS=Homo sapiens OX=9606 GN=DCHS2 PE=1 SV=2" "0.002" "False" "2.968" "0" "2" "2" "2" "3371" "370.0" "4.77" "5.39" "2" "cell adhesion;cell cycle OR cell proliferation;developmental processes" "plasma membrane;other membranes" "other molecular function" "Pf00028" "54798" "ENSG00000197410; ENSG00000284227" "DCHS2" "A0A096LNH0; B2RU14; E9PC11; hsa:54798; Q4W5P9; Q6V1P9; Q6ZS61; Q9NXU8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3774842769131475239" "False" "High" "IsMasterProtein" "Q9Y2R5" "Small ribosomal subunit protein uS17m OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1" "0.002" "False" "2.967" "8" "1" "1" "1" "130" "14.5" "9.85" "2.80" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf00366" "51373" "ENSG00000239789" "MRPS17" "hsa:51373; Q86X15; Q9Y2R5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.275" "0.738" "1.291" "1.077" "0.850" "1.108" "0.759" "0.957" "1.490" "21.3" "27.2" "15.7" "27.5" "23.0" "18.1" "23.6" "16.2" "20.4" "31.8" "" "" "" "" "" "" "" "" "" "" "19.2" "21.0" "12.2" "18.5" "19.2" "15.5" "20.0" "11.7" "13.8" "31.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387602003086690885" "False" "High" "IsMasterProtein" "Q9BVC5" "Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1" "0.002" "False" "2.962" "3" "1" "3" "1" "232" "25.8" "9.74" "6.18" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf15323" "79074" "ENSG00000135974" "C2orf49" "B3KXN3; B4E2G9; hsa:79074; Q9BVC5" "tRNA processing in the nucleus" "" "1" "0" "1.026" "0.801" "0.991" "0.908" "0.658" "1.006" "1.022" "0.734" "1.097" "204.3" "209.5" "163.6" "202.5" "185.4" "134.4" "205.6" "208.8" "149.9" "224.1" "" "" "" "" "" "" "" "" "" "" "184.4" "161.6" "126.5" "136.4" "154.7" "114.7" "174.4" "151.1" "101.1" "224.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112026886534242272" "False" "High" "IsMasterProtein" "Q99653" "Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3" "0.002" "False" "2.961" "4" "1" "1" "1" "195" "22.4" "5.10" "2.86" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00036" "11261" "ENSG00000187446" "CHP1" "B2R6H9; hsa:11261; Q6FHZ9; Q99653" "Hyaluronan uptake and degradation" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8320420744586431417" "False" "High" "IsMasterProtein" "Q5JV73" "FERM and PDZ domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FRMPD3 PE=1 SV=3" "0.002" "False" "2.954" "1" "1" "2" "1" "1777" "195.5" "8.25" "2.64" "1" "" "plasma membrane;other membranes;cytoskeleton" "" "Pf00373, Pf00595, Pf21477" "" "ENSG00000147234" "FRMPD3" "A0A804HKI5; hsa:84443; Q5JV73; Q96JK8" "Neutrophil degranulation" "" "1" "0" "0.910" "0.778" "1.114" "0.941" "0.830" "0.956" "0.888" "1.022" "1.489" "133.8" "121.7" "104.1" "149.0" "125.9" "111.0" "127.9" "118.8" "136.7" "199.1" "" "" "" "" "" "" "" "" "" "" "120.7" "93.9" "80.5" "100.3" "105.0" "94.8" "108.5" "86.0" "92.2" "199.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5146194763557846941" "False" "High" "IsMasterProtein" "Q9Y613" "FH1/FH2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FHOD1 PE=1 SV=3" "0.002" "False" "2.944" "3" "2" "2" "2" "1164" "126.5" "6.39" "2.39" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf18382" "29109" "ENSG00000135723" "FHOD1" "hsa:29109; Q59F76; Q6Y1F2; Q76MS8; Q8N521; Q9Y613" "" "VEGFA-VEGFR2 signaling" "1" "0" "1.791" "1.559" "1.355" "1.406" "1.619" "1.541" "1.793" "1.892" "4.091" "10.8" "19.4" "16.9" "14.7" "15.2" "17.5" "16.7" "19.4" "20.5" "44.3" "" "" "" "" "" "" "" "" "" "" "9.8" "15.0" "13.1" "9.9" "12.7" "15.0" "14.2" "14.0" "13.8" "44.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3289873417268458662" "False" "High" "IsMasterProtein" "Q9NX40" "OCIA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OCIAD1 PE=1 SV=1" "0.002" "False" "2.943" "3" "1" "1" "1" "245" "27.6" "7.49" "3.12" "1" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "54940" "ENSG00000109180" "OCIAD1" "C9K030; G8JLN7; hsa:54940; Q9BZE8; Q9NX40" "" "" "0" "0" "0.957" "1.163" "1.044" "0.875" "1.215" "1.010" "1.037" "1.034" "0.964" "70.4" "67.4" "81.9" "73.5" "61.6" "85.5" "71.1" "73.0" "72.8" "67.8" "" "" "" "" "" "" "" "" "" "" "63.5" "52.0" "63.3" "49.5" "51.4" "73.0" "60.3" "52.8" "49.1" "67.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-404480449398085068" "False" "High" "IsMasterProtein" "P51809" "Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3" "0.002" "False" "2.942" "4" "1" "1" "1" "220" "24.9" "8.60" "2.48" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "6845" "ENSG00000124333; ENSG00000292366" "VAMP7" "hsa:6845; P51809; Q53GY7; Q7Z409; Q9H4A7" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Interleukin-12 signaling" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2183625062591563072" "False" "High" "IsMasterProtein" "Q9NZT1" "Calmodulin-like protein 5 OS=Homo sapiens OX=9606 GN=CALML5 PE=1 SV=2" "0.002" "False" "2.932" "5" "1" "1" "1" "146" "15.9" "4.44" "3.02" "1" "signal transduction;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "51806" "ENSG00000178372" "CALML5" "hsa:51806; Q5SQI3; Q8IXU8; Q9NZT1" "Neutrophil degranulation" "Alzheimer's disease and miRNA effects; Ras signaling; Melanoma; Alzheimer's disease" "5" "0" "1.581" "1.863" "1.377" "1.267" "2.916" "1.167" "1.042" "2.869" "0.969" "73.6" "116.3" "137.1" "101.3" "93.2" "214.6" "85.9" "76.6" "211.1" "71.3" "" "" "" "" "" "" "" "" "" "" "66.4" "89.7" "106.0" "68.2" "77.8" "183.1" "72.8" "55.5" "142.4" "71.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8519272839618929439" "False" "High" "IsMasterProtein" "P29017" "T-cell surface glycoprotein CD1c OS=Homo sapiens OX=9606 GN=CD1C PE=1 SV=2" "0.002" "False" "2.919" "3" "1" "1" "1" "333" "37.6" "6.14" "2.29" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07654, Pf16497" "911" "ENSG00000158481" "CD1C" "hsa:911; P29017; Q5TDJ7; Q6IAS4; Q9UMM0; Q9UN96" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "" "1" "0" "0.815" "0.951" "0.957" "0.967" "0.922" "0.834" "0.995" "0.944" "0.799" "47.9" "39.0" "45.5" "45.8" "46.3" "44.2" "39.9" "47.6" "45.2" "38.3" "" "" "" "" "" "" "" "" "" "" "43.2" "30.1" "35.2" "30.8" "38.6" "37.7" "33.9" "34.5" "30.5" "38.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249152470973198342" "False" "High" "IsMasterProtein" "Q9NYZ3" "G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=4" "0.002" "False" "2.914" "1" "1" "1" "1" "739" "78.5" "9.23" "3.20" "1" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15259" "51512" "ENSG00000075218" "GTSE1" "B0QYM3; hsa:51512; Q20WK2; Q53GX5; Q5R3I6; Q6DHX4; Q9BRE0; Q9NYZ3; Q9UGZ9; Q9Y557" "G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint" "" "2" "0" "1.050" "0.842" "1.120" "1.168" "0.683" "1.063" "1.151" "0.738" "1.535" "175.5" "184.2" "147.7" "196.5" "205.0" "119.9" "186.6" "202.1" "129.5" "269.3" "" "" "" "" "" "" "" "" "" "" "158.4" "142.1" "114.3" "132.3" "171.0" "102.4" "158.3" "146.2" "87.3" "269.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5626917880360896955" "False" "High" "IsMasterProtein" "Q8N201" "Integrator complex subunit 1 OS=Homo sapiens OX=9606 GN=INTS1 PE=1 SV=2" "0.002" "False" "2.904" "1" "2" "2" "2" "2190" "244.1" "6.13" "2.19" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus" "" "Pf12432" "26173" "ENSG00000164880" "INTS1" "A6NJ44; hsa:26173; Q6NT70; Q6UX74; Q8N201; Q8WV40; Q96D36; Q9NTD1; Q9P2A8; Q9Y3W8" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2805151388024258847" "False" "High" "IsMasterProtein" "Cont_Q28107" "Coagulation factor V OS=Bos taurus OX=9913 GN=F5 PE=1 SV=1" "0.002" "True" "2.903" "0" "1" "1" "1" "2211" "248.8" "5.83" "3.48" "1" "stress response;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf00754, Pf06049, Pf07732" "280687" "" "F5" "bta:280687; Q28107; Q28108" "" "" "0" "0" "1.184" "1.783" "1.746" "1.258" "1.910" "1.159" "1.289" "1.655" "1.043" "32.5" "38.5" "57.9" "56.7" "40.9" "62.1" "37.7" "41.9" "53.8" "33.9" "" "" "" "" "" "" "" "" "" "" "29.3" "29.7" "44.8" "38.2" "34.1" "53.0" "31.9" "30.3" "36.3" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7069334460136082352" "False" "High" "IsMasterProtein" "Q9Y4P8" "WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens OX=9606 GN=WIPI2 PE=1 SV=1" "0.002" "False" "2.900" "2" "1" "1" "1" "454" "49.4" "6.46" "2.73" "1" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf21032" "26100" "ENSG00000157954" "WIPI2" "B3KNC2; hsa:26100; Q5MNZ8; Q6FI96; Q75L50; Q96IE4; Q9Y364; Q9Y4P8" "Macroautophagy" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8268221381324165575" "False" "High" "IsMasterProtein" "Q96B96" "Lipid droplet assembly factor 1 OS=Homo sapiens OX=9606 GN=LDAF1 PE=1 SV=2" "0.002" "False" "2.900" "5" "1" "1" "1" "161" "17.5" "5.06" "3.30" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf16015" "57146" "ENSG00000011638" "LDAF1" "A6NMA9; B4DEC1; hsa:57146; O00323; Q96B96" "" "" "0" "0" "1.330" "1.081" "1.232" "1.138" "0.979" "1.359" "1.154" "1.122" "1.120" "98.9" "131.6" "106.9" "121.9" "112.5" "96.8" "134.4" "114.2" "111.0" "110.7" "" "" "" "" "" "" "" "" "" "" "89.3" "101.5" "82.7" "82.1" "93.8" "82.6" "114.0" "82.6" "74.8" "110.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2564632356119292656" "False" "High" "IsMasterProtein" "P04843" "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Homo sapiens OX=9606 GN=RPN1 PE=1 SV=1" "0.002" "False" "2.900" "1" "1" "1" "1" "607" "68.5" "6.38" "2.14" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf04597" "6184" "ENSG00000163902" "RPN1" "B2R5Z0; D3DNB6; hsa:6184; P04843; Q68DT1" "SRP-dependent cotranslational protein targeting to membrane; Asparagine N-linked glycosylation; Maturation of spike protein" "Proteasome degradation; N-glycan biosynthesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821659264702231707" "False" "High" "IsMasterProtein" "P13284" "Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens OX=9606 GN=IFI30 PE=1 SV=3" "0.002" "False" "2.898" "4" "1" "1" "1" "250" "27.9" "4.88" "2.70" "1" "other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03227" "10437" "ENSG00000216490" "IFI30" "hsa:10437; P13284; Q76MF9; Q8NEI4; Q8WU77; Q9UL08" "MHC class II antigen presentation; Interferon gamma signaling" "" "2" "0" "0.530" "1.039" "0.355" "0.321" "1.246" "0.271" "0.725" "0.478" "0.286" "43.2" "22.9" "44.9" "15.3" "13.9" "53.9" "11.7" "31.3" "20.7" "12.4" "" "" "" "" "" "" "" "" "" "" "39.0" "17.7" "34.8" "10.3" "11.6" "46.0" "9.9" "22.7" "13.9" "12.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3937524236337839102" "False" "High" "IsMasterProtein" "P32121" "Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2" "0.002" "False" "2.893" "2" "1" "1" "1" "409" "46.1" "7.69" "2.63" "1" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00339, Pf02752" "409" "ENSG00000141480" "ARRB2" "B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688; hsa:409; P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6" "Ub-specific processing proteases; Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; Activation of SMO; G alpha (s) signalling events; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); WNT5A-dependent internalization of FZD4; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "Corticotropin-releasing hormone signaling pathway; Complement system; Myometrial relaxation and contraction pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells" "27" "0" "1.281" "0.900" "1.173" "1.341" "0.943" "0.973" "0.924" "0.909" "1.252" "46.3" "59.4" "41.7" "54.3" "62.1" "43.7" "45.1" "42.8" "42.1" "58.0" "" "" "" "" "" "" "" "" "" "" "41.8" "45.8" "32.3" "36.6" "51.8" "37.3" "38.2" "31.0" "28.4" "58.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851715051474233643" "False" "High" "IsMasterProtein" "Q9P2A4" "ABI gene family member 3 OS=Homo sapiens OX=9606 GN=ABI3 PE=1 SV=2" "0.002" "False" "2.887" "2" "1" "1" "1" "366" "39.0" "5.08" "2.98" "1" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "cytoskeletal activity;other molecular function" "Pf07815, Pf14604" "51225" "ENSG00000108798" "ABI3" "C9IZN8; hsa:51225; Q9H0P6; Q9P2A4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3737855785058777273" "False" "High" "IsMasterProtein" "Q9NSP4" "Centromere protein M OS=Homo sapiens OX=9606 GN=CENPM PE=1 SV=1" "0.002" "False" "2.880" "6" "1" "1" "1" "180" "19.7" "7.20" "2.28" "1" "cell cycle OR cell proliferation" "cytosol;nucleus;other cell component" "" "Pf11111" "79019" "ENSG00000100162" "CENPM" "A7LM22; B1AHQ9; hsa:79019; Q6I9W3; Q9NSP4" "Separation of Sister Chromatids; Deposition of new CENPA-containing nucleosomes at the centromere; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "0.903" "1.039" "0.829" "0.714" "0.774" "1.168" "0.850" "0.998" "2.209" "27.1" "24.5" "28.2" "22.5" "19.3" "21.0" "31.7" "23.1" "27.0" "59.9" "" "" "" "" "" "" "" "" "" "" "24.5" "18.9" "21.8" "15.1" "16.1" "17.9" "26.9" "16.7" "18.2" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415946790012265046" "False" "High" "IsMasterProtein" "O75586" "Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2" "0.002" "False" "2.879" "4" "1" "1" "1" "246" "28.4" "8.62" "1.97" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04934" "10001" "ENSG00000133997" "MED6" "B4DU17; B4E2P0; hsa:10001; O15401; O75586; Q53FE3; Q53HJ3; Q6FHQ4; Q9BTH1; Q9UHL1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5657020156058980872" "False" "High" "IsMasterProtein" "Q9UK22" "F-box only protein 2 OS=Homo sapiens OX=9606 GN=FBXO2 PE=1 SV=2" "0.002" "False" "2.876" "3" "1" "1" "1" "296" "33.3" "4.37" "2.27" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf04300, Pf12937" "26232" "ENSG00000116661" "FBXO2" "B2R7K7; hsa:26232; Q5TGY0; Q6FGJ7; Q8TB29; Q9UK22; Q9UKC6" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "1.601" "1.955" "1.826" "1.442" "1.052" "2.274" "1.835" "1.869" "1.564" "11.7" "18.7" "22.9" "21.4" "16.9" "12.3" "26.6" "21.5" "21.9" "18.3" "" "" "" "" "" "" "" "" "" "" "10.6" "14.5" "17.7" "14.4" "14.1" "10.5" "22.6" "15.5" "14.7" "18.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5269036548224773448" "False" "High" "IsMasterProtein" "Q6UXH1" "Protein disulfide isomerase CRELD2 OS=Homo sapiens OX=9606 GN=CRELD2 PE=1 SV=1" "0.002" "False" "2.875" "2" "1" "1" "1" "353" "38.2" "4.59" "3.19" "1" "" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf07645" "79174" "ENSG00000184164" "CRELD2" "A5GZA2; A5GZA3; A5GZA4; A5GZA5; A5GZA6; hsa:79174; Q4W0V0; Q6UXH1; Q86UC0; Q9BU47" "" "" "0" "0" "0.977" "1.174" "1.038" "1.167" "1.403" "1.011" "1.294" "1.349" "0.961" "111.2" "108.7" "130.6" "115.5" "129.9" "156.1" "112.5" "144.0" "150.1" "106.9" "" "" "" "" "" "" "" "" "" "" "100.4" "83.8" "101.0" "77.8" "108.3" "133.3" "95.4" "104.2" "101.2" "106.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3053469202622973433" "False" "High" "IsMasterProtein" "Q7L591" "Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2" "0.002" "False" "2.870" "3" "1" "1" "1" "496" "53.3" "7.77" "2.22" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf02174" "79930" "ENSG00000146094" "DOK3" "E9PAT0; H7BXS0; hsa:79930; Q7L591; Q8N864; Q9BQB3; Q9H666" "Neutrophil degranulation" "5q35 copy number variation" "2" "0" "0.708" "0.856" "0.907" "0.854" "0.857" "0.949" "0.812" "1.110" "0.517" "18.2" "12.9" "15.6" "16.5" "15.5" "15.6" "17.3" "14.8" "20.2" "9.4" "" "" "" "" "" "" "" "" "" "" "16.4" "9.9" "12.0" "11.1" "13.0" "13.3" "14.6" "10.7" "13.6" "9.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588052474242389854" "False" "High" "IsMasterProtein" "Q92766" "Ras-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=RREB1 PE=1 SV=3" "0.002" "False" "2.863" "1" "1" "1" "1" "1687" "181.3" "6.98" "3.16" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894, Pf13912" "6239" "ENSG00000124782" "RREB1" "A2RRF5; E2GM80; E2GM81; hsa:6239; O75567; O75568; Q5VYB2; Q6BEP5; Q6BEP6; Q6BEP8; Q86SU2; Q92766; Q9Y474" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629743064100226613" "False" "High" "IsMasterProtein" "Q8TAK5" "GA-binding protein subunit beta-2 OS=Homo sapiens OX=9606 GN=GABPB2 PE=1 SV=1" "0.002" "False" "2.862" "2" "1" "1" "1" "448" "48.6" "5.26" "2.94" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12796" "126626" "ENSG00000143458" "GABPB2" "B1AVJ8; D3DV14; hsa:126626; Q8NAR5; Q8TAK5" "" "" "0" "0" "1.295" "1.931" "1.222" "1.311" "2.155" "1.231" "1.191" "2.095" "2.710" "82.0" "106.2" "158.3" "100.2" "107.5" "176.6" "100.9" "97.6" "171.7" "222.1" "" "" "" "" "" "" "" "" "" "" "74.0" "81.9" "122.4" "67.5" "89.6" "150.8" "85.6" "70.6" "115.8" "222.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981490796003058050" "False" "High" "IsMasterProtein" "Q9H4P4" "E3 ubiquitin-protein ligase NRDP1 OS=Homo sapiens OX=9606 GN=RNF41 PE=1 SV=2" "0.002" "False" "2.859" "3" "1" "1" "1" "317" "35.9" "6.14" "2.91" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08941, Pf13923" "10193" "ENSG00000181852" "RNF41" "A6NFW0; B2RBT8; hsa:10193; O75598; Q9H4P4" "Antigen processing: Ubiquitination & Proteasome degradation; Downregulation of ERBB2:ERBB3 signaling" "" "2" "0" "0.992" "1.348" "1.188" "1.153" "0.990" "1.133" "0.941" "0.880" "1.219" "31.2" "31.0" "42.1" "37.0" "36.0" "30.9" "35.4" "29.4" "27.4" "38.0" "" "" "" "" "" "" "" "" "" "" "28.2" "23.9" "32.5" "24.9" "30.0" "26.4" "30.0" "21.2" "18.5" "38.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8950408743700017704" "False" "High" "IsMasterProtein" "O60645" "Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3" "0.002" "False" "2.857" "1" "1" "1" "1" "745" "85.5" "6.29" "3.01" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06046" "11336" "ENSG00000180104" "EXOC3" "hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Ciliary landscape" "4" "0" "1.104" "0.708" "0.832" "1.073" "0.788" "0.827" "0.662" "1.041" "3.132" "20.9" "23.0" "14.8" "17.4" "22.4" "16.5" "17.3" "13.8" "21.7" "65.4" "" "" "" "" "" "" "" "" "" "" "18.8" "17.8" "11.4" "11.7" "18.7" "14.0" "14.6" "10.0" "14.7" "65.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5677827102624180499" "False" "High" "IsMasterProtein" "Q96IQ9" "Zinc finger protein 414 OS=Homo sapiens OX=9606 GN=ZNF414 PE=1 SV=2" "0.002" "False" "2.851" "4" "1" "1" "1" "312" "32.8" "7.81" "2.53" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15909" "84330" "ENSG00000133250" "ZNF414" "A8MY94; hsa:84330; Q96IQ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-815619529761870657" "False" "High" "IsMasterProtein" "Q6P996" "Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2" "0.002" "False" "2.851" "1" "1" "1" "1" "788" "86.7" "5.38" "2.44" "1" "other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00282" "23042" "ENSG00000179889; ENSG00000275498" "PDXDC1" "B4DR55; B4DSL3; E7EMH5; E7EPL4; H3BNZ1; hsa:23042; O00236; Q4F6X7; Q6P996; Q6PID7; Q86YF1; Q8N4Q9; Q8TBS5" "" "" "0" "0" "1.456" "1.327" "1.938" "1.359" "1.695" "1.467" "1.070" "1.680" "4.973" "17.3" "25.2" "23.0" "33.5" "23.5" "29.3" "25.4" "18.5" "29.1" "86.1" "" "" "" "" "" "" "" "" "" "" "15.6" "19.4" "17.8" "22.6" "19.6" "25.0" "21.5" "13.4" "19.6" "86.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5142259406840293622" "False" "High" "IsMasterProtein" "Q14738" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens OX=9606 GN=PPP2R5D PE=1 SV=1" "0.002" "False" "2.846" "2" "1" "1" "1" "602" "69.9" "8.13" "2.50" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5528" "ENSG00000112640" "PPP2R5D" "A8K3I9; B5BUA6; hsa:5528; O00494; O00696; Q14738; Q15171; Q5TC39" "Separation of Sister Chromatids; DARPP-32 events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "33" "0" "1.006" "0.902" "1.411" "1.181" "0.981" "0.884" "0.818" "1.450" "1.708" "18.2" "18.3" "16.4" "25.7" "21.5" "17.9" "16.1" "14.9" "26.4" "31.2" "" "" "" "" "" "" "" "" "" "" "16.5" "14.2" "12.7" "17.3" "18.0" "15.3" "13.7" "10.8" "17.8" "31.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3974339187776743055" "False" "High" "IsMasterProtein" "Q93074" "Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4" "0.002" "False" "2.844" "0" "1" "2" "1" "2177" "242.9" "7.05" "2.32" "1" "cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09497, Pf12144, Pf12145" "9968" "ENSG00000184634" "MED12" "hsa:9968; O15410; O75557; Q93074; Q9UHV6; Q9UND7" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.087" "0.892" "0.769" "0.980" "1.166" "0.972" "0.959" "0.995" "1.130" "62.3" "67.7" "55.6" "47.9" "61.0" "72.6" "60.6" "59.7" "62.0" "70.4" "" "" "" "" "" "" "" "" "" "" "56.2" "52.2" "43.0" "32.2" "50.9" "62.0" "51.4" "43.2" "41.8" "70.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1933221655195887303" "False" "High" "IsMasterProtein" "Q9ULX9" "Transcription factor MafF OS=Homo sapiens OX=9606 GN=MAFF PE=1 SV=2" "0.002" "False" "2.839" "5" "1" "1" "1" "164" "17.7" "9.80" "2.78" "1" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03131" "23764" "ENSG00000185022" "MAFF" "B4DV49; hsa:23764; Q9ULX9; Q9Y525" "Factors involved in megakaryocyte development and platelet production" "Nuclear receptors meta-pathway; NRF2 pathway; Myometrial relaxation and contraction pathways; Ethanol metabolism production of ROS by CYP2E1; Orexin receptor pathway" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "935705506060532462" "False" "High" "IsMasterProtein" "A0A0U1RRE5" "Negative regulator of P-body association OS=Homo sapiens OX=9606 GN=NBDY PE=1 SV=1" "0.002" "False" "2.832" "13" "1" "1" "1" "68" "7.0" "9.42" "3.47" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "" "" "550643" "ENSG00000204272" "NBDY" "A0A0U1RRE5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5936229442522610236" "False" "High" "IsMasterProtein" "Q9H204" "Mediator of RNA polymerase II transcription subunit 28 OS=Homo sapiens OX=9606 GN=MED28 PE=1 SV=1" "0.002" "False" "2.832" "5" "1" "1" "1" "178" "19.5" "5.58" "2.20" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity" "Pf11594" "80306" "ENSG00000118579" "MED28" "hsa:80306; Q9BZJ5; Q9H204" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5727120310183573784" "False" "High" "IsMasterProtein" "Q92560" "Ubiquitin carboxyl-terminal hydrolase BAP1 OS=Homo sapiens OX=9606 GN=BAP1 PE=1 SV=2" "0.002" "False" "2.826" "1" "1" "2" "1" "729" "80.3" "6.84" "1.95" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01088, Pf18031" "8314" "ENSG00000163930" "BAP1" "A8K993; hsa:8314; Q6LEM0; Q7Z5E8; Q92560" "UCH proteinases; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "Clear cell renal cell carcinoma pathways; Pleural mesothelioma; Kleefstra syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1046790815186603662" "False" "High" "IsMasterProtein" "Q8TB22" "Spermatogenesis-associated protein 20 OS=Homo sapiens OX=9606 GN=SPATA20 PE=1 SV=3" "0.002" "False" "2.822" "1" "1" "1" "1" "786" "87.8" "7.43" "2.75" "1" "other metabolic processes;other biological processes" "non-structural extracellular" "" "Pf03190" "64847" "ENSG00000006282" "SPATA20" "hsa:64847; Q2TA99; Q2XUZ6; Q6P0P1; Q8TB22; Q8WVW3; Q9H747" "" "" "0" "0" "0.875" "0.892" "0.909" "0.839" "0.994" "1.058" "0.906" "0.958" "0.959" "97.5" "85.3" "87.0" "88.6" "81.7" "96.9" "103.1" "88.3" "93.4" "93.5" "" "" "" "" "" "" "" "" "" "" "88.0" "65.8" "67.3" "59.7" "68.2" "82.7" "87.5" "63.9" "63.0" "93.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017174203569406372" "False" "High" "IsMasterProtein" "Q86UW6" "NEDD4-binding protein 2 OS=Homo sapiens OX=9606 GN=N4BP2 PE=1 SV=2" "0.002" "False" "2.820" "1" "1" "1" "1" "1770" "198.7" "5.21" "3.00" "1" "DNA metabolism" "cytosol" "kinase activity;other molecular function" "Pf01713, Pf08590, Pf13671" "55728" "ENSG00000078177" "N4BP2" "A0AVR3; hsa:55728; Q86UW6; Q9NVK2; Q9P2D4" "" "" "0" "0" "0.668" "1.833" "1.058" "0.891" "1.715" "0.938" "0.842" "1.590" "1.944" "43.2" "28.9" "79.2" "45.7" "38.5" "74.1" "40.5" "36.4" "68.7" "84.0" "" "" "" "" "" "" "" "" "" "" "39.0" "22.3" "61.3" "30.8" "32.1" "63.2" "34.4" "26.3" "46.3" "84.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1009047956554057166" "False" "High" "IsMasterProtein" "Q12756" "Kinesin-like protein KIF1A OS=Homo sapiens OX=9606 GN=KIF1A PE=1 SV=2" "0.002" "False" "2.810" "1" "2" "2" "2" "1690" "190.9" "6.21" "2.95" "2" "transport;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00225, Pf00498, Pf12423, Pf12473, Pf16183" "547" "ENSG00000130294" "KIF1A" "B0I1S5; F5H045; hsa:547; O95068; Q12756; Q13355; Q14752; Q2NKJ6; Q4LE42; Q53T78; Q59GH1; Q63Z40; Q6P1R9; Q7KZ57" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2q37 copy number variation syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7492712467309811415" "False" "High" "IsMasterProtein" "Q8WU58" "Protein FAM222B OS=Homo sapiens OX=9606 GN=FAM222B PE=1 SV=1" "0.002" "False" "2.810" "1" "1" "1" "1" "562" "59.6" "9.23" "2.85" "1" "" "nucleus" "" "Pf15258" "55731" "ENSG00000173065" "FAM222B" "hsa:55731; Q8WU58; Q9H6F3; Q9NVJ4; Q9NXN6" "" "" "0" "0" "1.044" "1.054" "1.224" "0.971" "0.735" "1.166" "1.133" "1.062" "1.164" "118.2" "123.4" "124.6" "144.7" "114.8" "87.0" "137.9" "134.0" "125.5" "137.6" "" "" "" "" "" "" "" "" "" "" "106.7" "95.2" "96.4" "97.4" "95.7" "74.2" "117.0" "96.9" "84.7" "137.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3627252899551957156" "False" "High" "IsMasterProtein" "Q9NSC5" "Homer protein homolog 3 OS=Homo sapiens OX=9606 GN=HOMER3 PE=1 SV=2" "0.002" "False" "2.807" "3" "1" "2" "1" "361" "39.8" "5.45" "5.01" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9454" "ENSG00000051128" "HOMER3" "B2RA10; E9PCW9; hsa:9454; O14580; O95350; Q9NSB9; Q9NSC0; Q9NSC1; Q9NSC5" "Neurexins and neuroligins" "PKC-gamma calcium signaling pathway in ataxia; Cell lineage map for neuronal differentiation" "3" "0" "0.943" "0.751" "0.939" "0.755" "0.588" "0.862" "0.847" "0.786" "1.050" "60.2" "56.8" "45.2" "56.5" "45.4" "35.4" "51.9" "51.0" "47.3" "63.2" "" "" "" "" "" "" "" "" "" "" "54.3" "43.8" "35.0" "38.1" "37.9" "30.2" "44.0" "36.9" "31.9" "63.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6544422487784178027" "False" "High" "IsMasterProtein" "Q8IVW6" "AT-rich interactive domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ARID3B PE=1 SV=2" "0.002" "False" "2.799" "4" "2" "3" "2" "561" "60.6" "7.52" "6.97" "2" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf01388" "10620" "ENSG00000179361" "ARID3B" "hsa:10620; O95443; Q59HC9; Q6P9C9; Q8IVW6" "" "" "0" "0" "1.278" "0.986" "1.546" "1.306" "1.399" "1.046" "1.311" "1.631" "1.593" "24.4" "31.2" "24.1" "37.8" "31.9" "34.2" "25.6" "32.0" "39.8" "38.9" "" "" "" "" "" "" "" "" "" "" "22.0" "24.1" "18.6" "25.4" "26.6" "29.2" "21.7" "23.2" "26.9" "38.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3163566102457861060" "False" "High" "IsMasterProtein" "Q8IWI9" "MAX gene-associated protein OS=Homo sapiens OX=9606 GN=MGA PE=1 SV=4" "0.002" "False" "2.795" "0" "1" "1" "1" "3065" "336.0" "6.90" "2.46" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00907, Pf16059" "23269" "ENSG00000174197" "MGA" "B9EGR5; E7ENI0; F5H7K2; hsa:23269; Q8IWI9; Q9H8R3; Q9H9N7; Q9UG69; Q9Y4E9" "Transcriptional Regulation by E2F6" "Pathways affected in adenoid cystic carcinoma" "2" "0" "0.936" "1.793" "0.937" "1.161" "1.942" "0.808" "1.019" "1.634" "3.752" "28.4" "26.6" "50.9" "26.6" "32.9" "55.1" "22.9" "28.9" "46.4" "106.4" "" "" "" "" "" "" "" "" "" "" "25.6" "20.5" "39.3" "17.9" "27.5" "47.0" "19.4" "20.9" "31.3" "106.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850217669682801799" "False" "High" "IsMasterProtein" "Q9NZD8" "Maspardin OS=Homo sapiens OX=9606 GN=SPG21 PE=1 SV=1" "0.002" "False" "2.794" "3" "1" "3" "1" "308" "34.9" "6.28" "5.51" "1" "signal transduction" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf00561" "51324" "ENSG00000090487" "SPG21" "B4DW44; Q6ZMB6; Q9NZD8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8360736340109521171" "False" "High" "IsMasterProtein" "P57737" "Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7 PE=1 SV=2" "0.002" "False" "2.787" "2" "2" "2" "2" "925" "100.5" "5.80" "4.76" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity" "Pf00400, Pf08953, Pf16300" "79585" "ENSG00000262246; ENSG00000282725" "CORO7" "B4DFD6; B4DL18; hsa:79585; I3L416; P57737; Q17RK4" "" "" "0" "0" "0.803" "0.855" "1.003" "0.906" "0.891" "0.826" "0.654" "0.959" "3.321" "141.0" "113.2" "120.6" "141.4" "127.7" "125.6" "116.5" "92.2" "135.2" "468.2" "" "" "" "" "" "" "" "" "" "" "127.3" "87.3" "93.3" "95.2" "106.5" "107.2" "98.8" "66.7" "91.2" "468.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2598464737050709238" "False" "High" "IsMasterProtein" "Q96LD8" "Sentrin-specific protease 8 OS=Homo sapiens OX=9606 GN=SENP8 PE=1 SV=1" "0.002" "False" "2.786" "3" "1" "1" "1" "212" "24.1" "5.97" "2.92" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf02902" "123228" "ENSG00000166192" "SENP8" "hsa:123228; Q96LD8; Q96QA4" "Neddylation; UCH proteinases" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2936218477733222076" "False" "High" "IsMasterProtein" "Q8N6T7" "NAD-dependent protein deacylase sirtuin-6 OS=Homo sapiens OX=9606 GN=SIRT6 PE=1 SV=2" "0.002" "False" "2.786" "4" "1" "1" "1" "355" "39.1" "9.19" "2.83" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "51548" "ENSG00000077463" "SIRT6" "B2RCD0; hsa:51548; O75291; Q6IAF5; Q6PK99; Q8N6T7; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1" "Pre-NOTCH Transcription and Translation; Processing of DNA double-strand break ends" "SREBF and miR33 in cholesterol and lipid homeostasis; NAD+ metabolism; NAD+ biosynthetic pathways; Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 10q11.21q11.23 copy number variation syndrome" "9" "0" "1.101" "1.015" "1.395" "1.107" "1.088" "1.201" "0.584" "1.236" "5.921" "9.2" "10.1" "9.3" "12.8" "10.2" "10.0" "11.1" "5.4" "11.4" "54.5" "" "" "" "" "" "" "" "" "" "" "8.3" "7.8" "7.2" "8.6" "8.5" "8.5" "9.4" "3.9" "7.7" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7159036767897580858" "False" "High" "IsMasterProtein" "P20036" "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" "0.002" "False" "2.785" "3" "1" "1" "1" "260" "29.4" "5.21" "2.85" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00993, Pf07654" "3113" "ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177" "HLA-DPA1" "A9YWH7; B9UKH4; O19722; O46883; P01905; P20036; P79554; Q2Q060; Q2Q061; Q5EY03; Q5STP1; Q6DQK4; Q9BCQ1; Q9TPX3; Q9XS10" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "Allograft rejection; Ebola virus infection in host" "9" "0" "0.896" "1.344" "1.040" "0.931" "1.280" "1.143" "1.244" "1.098" "0.638" "92.8" "83.1" "124.7" "96.5" "86.4" "118.7" "106.1" "115.4" "101.9" "59.2" "" "" "" "" "" "" "" "" "" "" "83.7" "64.1" "96.4" "65.0" "72.1" "101.3" "90.0" "83.5" "68.7" "59.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986646952840969808" "False" "High" "IsMasterProtein" "Q9BUE6" "Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA1 PE=1 SV=1" "0.002" "False" "2.778" "9" "1" "1" "1" "129" "14.2" "9.07" "2.46" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01521" "81689" "ENSG00000135070" "ISCA1" "B3KP34; B4DJI5; hsa:81689; Q8ND75; Q9BUE6; Q9BZR2" "Mitochondrial iron-sulfur cluster biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "576551174696518957" "False" "High" "IsMasterProtein" "Q5T447" "E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1" "0.002" "False" "2.771" "2" "1" "1" "1" "861" "97.1" "5.64" "2.34" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632, Pf03256" "79654" "ENSG00000126107" "HECTD3" "B3KPV7; B3KRH4; hsa:79654; Q5T447; Q5T448; Q9H783" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.045" "0.714" "0.869" "0.661" "0.587" "0.937" "0.762" "0.845" "0.822" "49.4" "51.7" "35.3" "43.0" "32.7" "29.0" "46.3" "37.7" "41.8" "40.7" "" "" "" "" "" "" "" "" "" "" "44.6" "39.9" "27.3" "28.9" "27.3" "24.8" "39.3" "27.3" "28.2" "40.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9106014466644302785" "False" "High" "IsMasterProtein" "Q9Y5Q8" "General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2" "0.002" "False" "2.761" "4" "2" "2" "2" "519" "59.5" "6.90" "4.33" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09734, Pf17682" "9328" "ENSG00000148308" "GTF3C5" "A6NI44; A6NJB9; hsa:9328; Q5T7U2; Q5T7U3; Q8N2U7; Q8N857; Q96GD9; Q9H4P2; Q9Y5Q8" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2173979595876030532" "False" "High" "IsMasterProtein" "Q9Y4I1" "Unconventional myosin-Va OS=Homo sapiens OX=9606 GN=MYO5A PE=1 SV=2" "0.002" "False" "2.754" "0" "1" "1" "1" "1855" "215.3" "8.48" "2.76" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf01843" "4644" "ENSG00000197535" "MYO5A" "A8MZC5; hsa:4644; O60653; Q07902; Q16249; Q9UE30; Q9UE31; Q9Y4I1" "Regulation of actin dynamics for phagocytic cup formation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; FCGR3A-mediated phagocytosis" "Joubert syndrome; 2q37 copy number variation syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-621581403936215319" "False" "High" "IsMasterProtein" "Q96B36" "Proline-rich AKT1 substrate 1 OS=Homo sapiens OX=9606 GN=AKT1S1 PE=1 SV=1" "0.002" "False" "2.746" "3" "1" "1" "1" "256" "27.4" "4.75" "2.81" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf15798" "84335" "ENSG00000204673" "AKT1S1" "A8MTQ1; B2RE93; hsa:84335; J3KPM3; Q96B36; Q96BI4; Q96IK7; Q96NG2; Q9BWR5" "HSF1-dependent transactivation; Constitutive Signaling by AKT1 E17K in Cancer; mTORC1-mediated signalling; AKT phosphorylates targets in the cytosol" "Target of rapamycin signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP" "22" "0" "1.171" "1.174" "1.196" "1.286" "1.090" "1.291" "1.260" "1.133" "1.174" "55.4" "64.9" "65.1" "66.3" "71.3" "60.4" "71.6" "69.8" "62.8" "65.1" "" "" "" "" "" "" "" "" "" "" "50.0" "50.1" "50.4" "44.6" "59.5" "51.6" "60.7" "50.5" "42.4" "65.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4054335882506265826" "False" "High" "IsMasterProtein" "Q8TE73" "Dynein axonemal heavy chain 5 OS=Homo sapiens OX=9606 GN=DNAH5 PE=1 SV=3" "0.002" "False" "2.746" "0" "1" "2" "1" "4624" "528.7" "6.10" "2.07" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf17857, Pf18198, Pf18199" "1767" "ENSG00000039139" "DNAH5" "hsa:1767; Q8TE73; Q92860; Q96L74; Q9H5S7; Q9HCG9" "" "" "0" "0" "1.106" "0.838" "1.161" "0.857" "0.778" "1.035" "1.085" "0.918" "0.311" "19.8" "21.9" "16.6" "23.0" "17.0" "15.4" "20.5" "21.5" "18.2" "6.2" "" "" "" "" "" "" "" "" "" "" "17.9" "16.9" "12.8" "15.5" "14.2" "13.1" "17.4" "15.5" "12.3" "6.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9109513475254745228" "False" "High" "IsMasterProtein" "Q9UBD5" "Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1" "0.002" "False" "2.744" "1" "1" "1" "1" "711" "82.2" "7.61" "2.74" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07034, Pf18137, Pf19675" "23595" "ENSG00000135336" "ORC3" "A2A2T5; B4E025; hsa:23595; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UBD5; Q9UG44; Q9UNT6" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "Cell cycle; G1 to S cell cycle control; DNA replication" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7606738261010209794" "False" "High" "IsMasterProtein" "Q7Z569" "BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2" "0.002" "False" "2.744" "2" "1" "2" "1" "592" "67.3" "5.92" "4.43" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02148, Pf07576, Pf13639" "8315" "ENSG00000089234" "BRAP" "B4DRM1; B9EGS8; hsa:8315; O43238; O75341; Q7Z569" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Negative regulation of MAPK pathway" "Ras signaling" "6" "0" "0.635" "1.253" "1.208" "0.744" "0.935" "0.779" "0.927" "0.856" "2.673" "21.0" "13.3" "26.3" "25.4" "15.6" "19.6" "16.3" "19.5" "18.0" "56.1" "" "" "" "" "" "" "" "" "" "" "18.9" "10.3" "20.3" "17.1" "13.0" "16.7" "13.9" "14.1" "12.1" "56.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5985118232380264359" "False" "High" "IsMasterProtein" "Q15363" "Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1" "0.002" "False" "2.736" "4" "1" "1" "1" "201" "22.7" "5.17" "2.43" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "Pf01105" "10959" "ENSG00000086598" "TMED2" "hsa:10959; Q15363" "COPII-mediated vesicle transport; Cargo concentration in the ER; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Pre-NOTCH Processing in Golgi" "5q35 copy number variation" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4762125104752177783" "False" "High" "IsMasterProtein" "A0JNW5" "Bridge-like lipid transfer protein family member 3B OS=Homo sapiens OX=9606 GN=BLTP3B PE=1 SV=2" "0.002" "False" "2.736" "1" "1" "1" "1" "1464" "164.1" "6.32" "3.17" "1" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf12624" "23074" "ENSG00000111647" "BLTP3B" "A0JNW5; A0PJE5; hsa:23074; O75183; Q8NDL1; Q96C30; Q9BTS5; Q9H0F1" "RND2 GTPase cycle" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7726317818688943966" "False" "High" "IsMasterProtein" "Q9NQC3" "Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2" "0.003" "False" "2.729" "1" "1" "1" "1" "1192" "129.9" "4.50" "2.44" "1" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02453" "57142" "ENSG00000115310" "RTN4" "O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9NQC3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6" "Axonal growth inhibition (RHOA activation)" "Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; 13q12.12 copy number variation" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3143696315815793188" "False" "High" "IsMasterProtein" "Q8WXH0" "Nesprin-2 OS=Homo sapiens OX=9606 GN=SYNE2 PE=1 SV=3" "0.003" "False" "2.727" "0" "2" "2" "2" "6885" "795.9" "5.36" "4.99" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23224" "ENSG00000054654" "SYNE2" "B4DND7; B4DPR6; I6XXQ5; Q540G1; Q86YP9; Q8N1S3; Q8NF49; Q8TER7; Q8WWW3; Q8WWW4; Q8WWW5; Q8WXH0; Q8WXH1; Q9NU50; Q9UFQ4; Q9Y2L4; Q9Y4R1" "Meiotic synapsis" "Ovarian infertility; Rett syndrome; Envelope proteins and their potential roles in EDMD physiopathology" "4" "0" "1.157" "0.816" "1.168" "1.171" "0.937" "0.978" "1.064" "0.872" "0.800" "78.8" "91.1" "64.3" "92.0" "92.3" "73.8" "77.1" "83.8" "68.7" "63.0" "" "" "" "" "" "" "" "" "" "" "71.1" "70.3" "49.7" "62.0" "77.0" "63.0" "65.4" "60.7" "46.3" "63.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177131133338512997" "False" "High" "IsMasterProtein" "Q8IXM3" "Large ribosomal subunit protein mL41 OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" "0.003" "False" "2.722" "7" "1" "1" "1" "137" "15.4" "9.57" "2.76" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09809" "64975" "ENSG00000182154" "MRPL41" "hsa:64975; Q8IXM3; Q96Q49" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "0.837" "0.713" "0.766" "0.856" "0.679" "0.898" "1.074" "0.748" "0.995" "74.1" "62.0" "52.8" "56.8" "63.4" "50.3" "66.5" "79.6" "55.4" "73.7" "" "" "" "" "" "" "" "" "" "" "66.9" "47.8" "40.9" "38.2" "52.9" "42.9" "56.4" "57.6" "37.4" "73.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654613729152941586" "False" "High" "IsMasterProtein" "P23786" "Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CPT2 PE=1 SV=2" "0.003" "False" "2.720" "1" "1" "1" "1" "658" "73.7" "8.18" "2.31" "1" "other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00755" "1376" "ENSG00000157184" "CPT2" "B2R6S0; hsa:1376; P23786; Q5SW68; Q9BQ26" "PPARA activates gene expression; Carnitine metabolism" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Thermogenesis; Mitochondrial fatty acid oxidation disorders" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3307740507172488716" "False" "High" "IsMasterProtein" "Q9BRR6" "ADP-dependent glucokinase OS=Homo sapiens OX=9606 GN=ADPGK PE=1 SV=1" "0.003" "False" "2.718" "3" "1" "1" "1" "497" "54.1" "6.20" "1.76" "1" "other metabolic processes" "non-structural extracellular;other membranes;ER/Golgi" "kinase activity;other molecular function" "Pf04587" "83440" "ENSG00000159322" "ADPGK" "hsa:83440; Q49AU7; Q8NBI1; Q8WZ90; Q96NF8; Q9BRR6; Q9H0A7" "Glycolysis" "" "1" "0" "0.970" "0.918" "0.836" "0.650" "0.868" "0.789" "0.947" "1.004" "0.974" "70.8" "68.7" "65.0" "59.2" "46.0" "61.5" "55.8" "67.1" "71.1" "68.9" "" "" "" "" "" "" "" "" "" "" "63.9" "53.0" "50.3" "39.9" "38.4" "52.5" "47.4" "48.5" "47.9" "68.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465431971745530473" "False" "High" "IsMasterProtein" "Q3KRA9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Homo sapiens OX=9606 GN=ALKBH6 PE=1 SV=2" "0.003" "False" "2.711" "3" "1" "1" "1" "238" "26.5" "8.78" "2.49" "1" "" "nucleus;other cell component" "other molecular function" "Pf13532" "84964" "ENSG00000239382" "ALKBH6" "A5LGM8; A6NLP1; A8MU96; hsa:84964; Q3KRA9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286637805257654056" "False" "High" "IsMasterProtein" "Q9BQG0" "Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2" "0.003" "False" "2.711" "1" "1" "1" "1" "1328" "148.8" "9.28" "2.73" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04931" "10514" "ENSG00000132382" "MYBBP1A" "hsa:10514; Q86VM3; Q9BQG0; Q9BW49; Q9P0V5; Q9UF99" "B-WICH complex positively regulates rRNA expression" "Energy metabolism; 10q11.21q11.23 copy number variation syndrome" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214058643654551286" "False" "High" "IsMasterProtein" "Q9Y3Y2" "Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2" "0.003" "False" "2.707" "5" "1" "1" "1" "248" "26.4" "12.23" "3.70" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf13865" "26097" "ENSG00000160679" "CHTOP" "D3DV55; hsa:26097; Q0VAQ8; Q2VPI9; Q5T7Y8; Q5T7Y9; Q5T7Z0; Q6NSM4; Q6PB28; Q8WYT9; Q9BUC5; Q9H034; Q9H2L0; Q9Y3Y2" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "" "3" "0" "1.050" "1.005" "1.308" "1.126" "1.141" "1.232" "1.302" "1.183" "1.261" "48.4" "50.8" "48.6" "63.3" "54.5" "55.2" "59.6" "63.0" "57.3" "61.0" "" "" "" "" "" "" "" "" "" "" "43.7" "39.2" "37.6" "42.6" "45.5" "47.1" "50.6" "45.6" "38.6" "61.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1508959840554036408" "False" "High" "IsMasterProtein" "Q969V6" "Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1" "0.003" "False" "2.703" "1" "1" "1" "1" "931" "98.9" "5.86" "3.55" "1" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02037, Pf02755" "57591" "ENSG00000196588" "MRTFA" "hsa:57591; Q8TCL1; Q969V6; Q96SC5; Q96SC6; Q9P2B0" "RHO GTPases Activate Formins; SUMOylation of transcription cofactors" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1745587393754728304" "False" "High" "IsMasterProtein" "Q9NQZ2" "Something about silencing protein 10 OS=Homo sapiens OX=9606 GN=UTP3 PE=1 SV=1" "0.003" "False" "2.697" "2" "1" "1" "1" "479" "54.5" "5.62" "2.95" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf04000, Pf09368" "57050" "ENSG00000132467" "UTP3" "hsa:57050; Q6FI82; Q9NQZ2" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342427626710048975" "False" "High" "IsMasterProtein" "Q96SW2" "Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1" "0.003" "False" "2.697" "2" "1" "1" "1" "442" "50.5" "5.63" "2.93" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02190, Pf03226" "51185" "ENSG00000113851" "CRBN" "B2R6H4; C9IZA9; C9JAH6; hsa:51185; Q6AI62; Q6NVZ0; Q96SW2; Q9UHW4" "Potential therapeutics for SARS" "" "1" "0" "0.968" "0.883" "0.965" "1.049" "1.149" "0.954" "1.251" "0.917" "0.737" "56.3" "54.5" "49.7" "54.3" "59.0" "64.7" "53.7" "70.4" "51.6" "41.5" "" "" "" "" "" "" "" "" "" "" "50.8" "42.1" "38.4" "36.6" "49.2" "55.2" "45.6" "51.0" "34.8" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6108723454848240584" "False" "High" "IsMasterProtein" "Q7L7X3" "Serine/threonine-protein kinase TAO1 OS=Homo sapiens OX=9606 GN=TAOK1 PE=1 SV=1" "0.003" "False" "2.696" "2" "2" "2" "1" "1001" "116.0" "7.65" "2.15" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "57551" "ENSG00000160551" "TAOK1" "A2RUT8; B7ZLV6; hsa:57551; Q7L7X3; Q96L75; Q9H2K7; Q9H7S5; Q9P2I6" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Microtubule cytoskeleton regulation; MAPK signaling pathway" "8" "0" "0.922" "0.877" "1.090" "1.155" "0.840" "0.794" "1.129" "1.498" "0.797" "13.0" "12.0" "11.4" "14.2" "15.0" "10.9" "10.3" "14.7" "19.4" "10.3" "" "" "" "" "" "" "" "" "" "" "11.7" "9.2" "8.8" "9.5" "12.5" "9.3" "8.7" "10.6" "13.1" "10.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "859606760973151215" "False" "High" "IsMasterProtein" "Q562F6" "Shugoshin 2 OS=Homo sapiens OX=9606 GN=SGO2 PE=1 SV=2" "0.003" "False" "2.691" "1" "1" "1" "1" "1265" "144.7" "7.91" "2.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "" "151246" "ENSG00000163535" "SGO2" "hsa:151246; Q53RR9; Q53T20; Q562F6; Q86XY4; Q8IWK2; Q8IZK1; Q8N1Q5; Q96LQ3" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cohesin complex - Cornelia de Lange syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265591638708801395" "False" "High" "IsMasterProtein" "P62699" "Protein yippee-like 5 OS=Homo sapiens OX=9606 GN=YPEL5 PE=1 SV=1" "0.003" "False" "2.690" "10" "1" "1" "1" "121" "13.8" "7.31" "2.87" "1" "cell cycle OR cell proliferation" "non-structural extracellular;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03226" "51646" "ENSG00000119801" "YPEL5" "D6W568; hsa:51646; P62699; Q65Z97; Q8R174; Q9D6M1; Q9UMX7; Q9Y3C9" "Neutrophil degranulation" "Ciliary landscape" "2" "0" "1.261" "1.021" "1.031" "1.211" "1.144" "1.101" "0.898" "1.240" "1.473" "22.5" "28.3" "23.0" "23.2" "27.2" "25.7" "24.8" "20.2" "27.9" "33.1" "" "" "" "" "" "" "" "" "" "" "20.3" "21.9" "17.8" "15.6" "22.7" "21.9" "21.0" "14.6" "18.8" "33.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3538958500289371582" "False" "High" "IsMasterProtein" "P49336" "Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1" "0.003" "False" "2.682" "4" "2" "2" "2" "464" "53.3" "8.57" "1.69" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1024" "ENSG00000132964" "CDK8" "hsa:1024; P49336; Q5VUF3; Q6ISB5" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription" "Sterol regulatory element-binding proteins (SREBP) signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; lncRNA in canonical Wnt signaling and colorectal cancer" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2848165254260814565" "False" "High" "IsMasterProtein" "Q6ZQQ2" "Spermatogenesis-associated protein 31D1 OS=Homo sapiens OX=9606 GN=SPATA31D1 PE=1 SV=1" "0.003" "False" "2.675" "1" "1" "2" "1" "1576" "175.5" "8.85" "4.31" "1" "other biological processes" "other membranes" "" "Pf14650, Pf15371" "389763" "ENSG00000214929" "SPATA31D1" "hsa:389763; Q6ZQQ2" "" "" "0" "0" "1.162" "1.078" "1.301" "1.040" "1.102" "1.274" "0.963" "1.252" "0.766" "112.3" "130.5" "121.0" "146.1" "116.7" "123.7" "143.1" "108.1" "140.6" "86.0" "" "" "" "" "" "" "" "" "" "" "101.3" "100.7" "93.6" "98.4" "97.4" "105.6" "121.4" "78.2" "94.8" "86.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4333754145708475207" "False" "High" "IsMasterProtein" "Q9UKT8" "F-box/WD repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=FBXW2 PE=1 SV=2" "0.003" "False" "2.673" "2" "1" "1" "1" "454" "51.5" "6.58" "3.84" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00400, Pf00646" "26190" "ENSG00000119402" "FBXW2" "B3KRL8; hsa:26190; Q4VXH2; Q7Z4V6; Q8WV51; Q9HA09; Q9UKA3; Q9UKT8" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "Wnt signaling pathway and pluripotency" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033266282732166818" "False" "High" "IsMasterProtein" "Q9Y663" "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 OS=Homo sapiens OX=9606 GN=HS3ST3A1 PE=1 SV=1" "0.003" "False" "2.670" "2" "1" "2" "1" "406" "44.9" "9.50" "5.12" "1" "protein metabolism;other metabolic processes;developmental processes" "other membranes;ER/Golgi" "other molecular function" "Pf00685" "9955" "ENSG00000153976" "HS3ST3A1" "A8K7N2; hsa:9955; Q9Y663" "HS-GAG biosynthesis" "Glycosaminoglycan synthesis in fibroblasts; Metapathway biotransformation Phase I and II" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5660529774365684631" "False" "High" "IsMasterProtein" "Q6WCQ1" "Myosin phosphatase Rho-interacting protein OS=Homo sapiens OX=9606 GN=MPRIP PE=1 SV=3" "0.003" "False" "2.668" "1" "1" "1" "1" "1025" "116.5" "6.21" "2.61" "1" "" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00169" "23164" "ENSG00000133030" "MPRIP" "hsa:23164; Q3KQZ5; Q5FB94; Q6DHW2; Q6WCQ1; Q7Z5Y2; Q8N390; Q96G40" "Signaling by BRAF and RAF1 fusions" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "2" "0" "1.267" "1.167" "1.255" "1.145" "1.334" "1.114" "1.131" "1.467" "1.143" "46.5" "58.9" "54.3" "58.4" "53.3" "62.0" "51.8" "52.6" "68.2" "53.2" "" "" "" "" "" "" "" "" "" "" "42.0" "45.4" "42.0" "39.3" "44.4" "52.9" "44.0" "38.1" "46.0" "53.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774592991242960215" "False" "High" "IsMasterProtein" "Q9H0H0" "Integrator complex subunit 2 OS=Homo sapiens OX=9606 GN=INTS2 PE=1 SV=2" "0.003" "False" "2.666" "1" "1" "1" "1" "1204" "134.2" "6.05" "2.49" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf14750" "57508" "ENSG00000108506" "INTS2" "hsa:57508; Q9H0H0; Q9ULD3" "RNA polymerase II transcribes snRNA genes" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836769617334137947" "False" "High" "IsMasterProtein" "Q96LA8" "Protein arginine N-methyltransferase 6 OS=Homo sapiens OX=9606 GN=PRMT6 PE=1 SV=1" "0.003" "False" "2.664" "2" "1" "1" "1" "375" "41.9" "5.44" "2.96" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf13649" "55170" "ENSG00000198890" "PRMT6" "A3KME1; B4DID8; hsa:55170; Q5T5Y5; Q6DKI4; Q96LA8; Q9NVR8" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines" "Male infertility; Nitric oxide metabolism in cystic fibrosis" "4" "0" "1.059" "0.980" "0.979" "1.039" "1.063" "0.962" "1.221" "0.811" "0.756" "74.9" "79.3" "73.4" "73.3" "77.8" "79.6" "72.0" "91.4" "60.7" "56.6" "" "" "" "" "" "" "" "" "" "" "67.6" "61.2" "56.8" "49.3" "64.9" "67.9" "61.1" "66.2" "41.0" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-794247632168197847" "False" "High" "IsMasterProtein" "Q8NI37" "Protein phosphatase PTC7 homolog OS=Homo sapiens OX=9606 GN=PPTC7 PE=1 SV=1" "0.003" "False" "2.662" "5" "1" "1" "1" "304" "32.6" "5.19" "2.65" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf07228" "160760" "ENSG00000196850" "PPTC7" "B3KWC5; hsa:160760; Q68DZ7; Q6UY82; Q8NI37" "" "" "0" "0" "1.621" "1.298" "1.444" "1.204" "1.290" "1.107" "1.203" "1.357" "0.987" "17.7" "28.6" "22.9" "25.5" "21.3" "22.8" "19.5" "21.2" "24.0" "17.4" "" "" "" "" "" "" "" "" "" "" "15.9" "22.1" "17.7" "17.2" "17.7" "19.4" "16.6" "15.4" "16.2" "17.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2751742477750142499" "False" "High" "IsMasterProtein" "Q15345" "Leucine-rich repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=LRRC41 PE=1 SV=3" "0.003" "False" "2.660" "1" "1" "1" "1" "812" "88.6" "8.38" "2.98" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "10489" "ENSG00000132128" "LRRC41" "A8K5G8; hsa:10489; Q15345; Q3MJ96; Q5TDF5; Q71RA8; Q9BSM0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; RHOBTB3 ATPase cycle" "" "3" "0" "1.112" "1.145" "1.162" "1.142" "0.992" "1.279" "0.961" "1.352" "5.411" "95.5" "106.1" "109.3" "110.9" "109.0" "94.7" "122.1" "91.8" "129.1" "516.6" "" "" "" "" "" "" "" "" "" "" "86.2" "81.9" "84.6" "74.7" "90.9" "80.9" "103.5" "66.4" "87.0" "516.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2564730176707544032" "False" "High" "IsMasterProtein" "O95479" "GDH/6PGL endoplasmic bifunctional protein OS=Homo sapiens OX=9606 GN=H6PD PE=1 SV=2" "0.003" "False" "2.659" "1" "1" "1" "1" "791" "88.8" "7.30" "2.97" "1" "other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf00479, Pf01182, Pf02781" "9563" "ENSG00000049239" "H6PD" "hsa:9563; O95479; Q4TT33; Q66I35; Q68DT3; R4GMU1" "" "Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism" "1" "0" "1.158" "0.911" "1.190" "1.209" "1.297" "0.997" "0.610" "0.973" "2.106" "25.8" "29.9" "23.5" "30.8" "31.3" "33.5" "25.8" "15.8" "25.1" "54.4" "" "" "" "" "" "" "" "" "" "" "23.3" "23.1" "18.2" "20.7" "26.1" "28.6" "21.9" "11.4" "17.0" "54.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7008442538818735376" "False" "High" "IsMasterProtein" "Q8N4T8" "3-oxoacyl-[acyl-carrier-protein] reductase OS=Homo sapiens OX=9606 GN=CBR4 PE=1 SV=3" "0.003" "False" "2.644" "4" "1" "1" "1" "237" "25.3" "9.33" "3.34" "1" "cell organization and biogenesis;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf13561" "84869" "ENSG00000145439" "CBR4" "hsa:84869; Q8N4T8; Q8WTW8; Q96K93" "Fatty acyl-CoA biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1879771635680972276" "False" "High" "IsMasterProtein" "O95208" "Epsin-2 OS=Homo sapiens OX=9606 GN=EPN2 PE=1 SV=3" "0.003" "False" "2.644" "1" "1" "2" "1" "641" "68.4" "7.52" "4.31" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "22905" "ENSG00000072134" "EPN2" "A8MTV8; B3KRX8; E9PBC2; hsa:22905; O95207; O95208; Q52LD0; Q9H7Z2; Q9UPT7" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8491275537287957660" "False" "High" "IsMasterProtein" "Q8NDD1" "Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1orf131 PE=1 SV=4" "0.003" "False" "2.636" "4" "1" "1" "1" "293" "32.6" "9.88" "2.98" "1" "other biological processes" "nucleus;other cell component" "" "Pf15375" "128061" "ENSG00000143633" "C1orf131" "Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q8NDD1; Q96NM6" "" "" "0" "0" "1.298" "0.980" "1.161" "1.008" "1.288" "1.060" "0.815" "1.377" "0.842" "30.1" "39.0" "29.5" "34.9" "30.3" "38.7" "31.9" "24.5" "41.4" "25.3" "" "" "" "" "" "" "" "" "" "" "27.1" "30.1" "22.8" "23.5" "25.3" "33.1" "27.0" "17.7" "27.9" "25.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "174890582361542950" "False" "High" "IsMasterProtein" "Q03052" "POU domain, class 3, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU3F1 PE=1 SV=3" "0.003" "False" "2.634" "3" "1" "1" "1" "451" "45.5" "7.74" "2.74" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "5453" "ENSG00000185668" "POU3F1" "hsa:5453; Q03052; Q5TAG2" "Formation of the anterior neural plate; Formation of the posterior neural plate; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4589433783542351991" "False" "High" "IsMasterProtein" "Q9NVU0" "DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1" "0.003" "False" "2.633" "1" "1" "1" "1" "708" "79.8" "6.47" "4.71" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "" "Pf04801, Pf19725" "55718" "ENSG00000058600; ENSG00000284282" "POLR3E" "B4DL24; B4DUP6; H3BT11; hsa:55718; Q9BWF7; Q9H8W8; Q9H907; Q9NVU0; Q9P276" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359859415185382416" "False" "High" "IsMasterProtein" "O75575" "DNA-directed RNA polymerase III subunit RPC9 OS=Homo sapiens OX=9606 GN=CRCP PE=1 SV=1" "0.003" "False" "2.632" "5" "1" "1" "1" "148" "16.9" "5.39" "3.40" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03874" "27297" "ENSG00000241258" "CRCP" "A8MUZ4; A8MW23; B2R4H4; B4E198; hsa:27297; O75575; Q3KRA3; Q5HYF1; Q8IXL4" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "Myometrial relaxation and contraction pathways" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8470400305204825802" "False" "High" "IsMasterProtein" "Q9Y485" "DmX-like protein 1 OS=Homo sapiens OX=9606 GN=DMXL1 PE=1 SV=3" "0.003" "False" "2.625" "0" "1" "1" "1" "3027" "337.6" "6.34" "2.63" "1" "other biological processes" "other cell component" "" "Pf00400, Pf12234" "1657" "ENSG00000172869" "DMXL1" "hsa:1657; Q9Y485" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2792434032950857374" "False" "High" "IsMasterProtein" "Q96HR3" "Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1" "0.003" "False" "2.618" "7" "1" "2" "1" "178" "20.3" "8.27" "2.04" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11315" "90390" "ENSG00000164758" "MED30" "C6GKU9; hsa:90390; Q96HR3" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "" "4" "0" "0.984" "0.592" "0.542" "0.893" "0.442" "0.652" "0.551" "0.721" "1.032" "22.4" "22.1" "13.3" "12.2" "20.0" "9.9" "14.6" "12.4" "16.2" "23.2" "" "" "" "" "" "" "" "" "" "" "20.3" "17.0" "10.3" "8.2" "16.7" "8.5" "12.4" "8.9" "10.9" "23.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1674970657433919693" "False" "High" "IsMasterProtein" "P51159" "Ras-related protein Rab-27A OS=Homo sapiens OX=9606 GN=RAB27A PE=1 SV=3" "0.003" "False" "2.616" "5" "1" "1" "1" "221" "24.9" "5.22" "2.82" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5873" "ENSG00000069974" "RAB27A" "hsa:5873; O00195; P51159; Q6FI40; Q9UIR9; Q9Y5U3" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Insulin processing" "Deregulation of Rab and Rab effector genes in bladder cancer; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; 2q37 copy number variation syndrome" "7" "0" "0.948" "0.838" "1.072" "1.061" "0.798" "1.082" "0.960" "0.847" "0.981" "71.9" "68.2" "60.3" "77.1" "76.3" "57.4" "77.8" "69.1" "60.9" "70.5" "" "" "" "" "" "" "" "" "" "" "64.9" "52.6" "46.6" "51.9" "63.6" "49.0" "66.0" "50.0" "41.1" "70.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9099415838211122916" "False" "High" "IsMasterProtein" "P33981" "Dual specificity protein kinase TTK OS=Homo sapiens OX=9606 GN=TTK PE=1 SV=2" "0.003" "False" "2.609" "2" "1" "1" "1" "857" "97.0" "8.16" "3.05" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7272" "ENSG00000112742" "TTK" "A8K8U5; B2RDW2; E1P543; hsa:7272; P33981; Q15272; Q5TCS0; Q9BW51; Q9NTM0" "" "Cell cycle; Retinoblastoma gene in cancer" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697558618654746564" "False" "High" "IsMasterProtein" "Q92546" "RAB6A-GEF complex partner protein 2 OS=Homo sapiens OX=9606 GN=RGP1 PE=1 SV=1" "0.003" "False" "2.609" "3" "1" "1" "1" "391" "42.4" "5.96" "2.19" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf08737" "9827" "ENSG00000107185" "RGP1" "hsa:9827; Q5TCV5; Q92546" "RAB GEFs exchange GTP for GDP on RABs; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8473772251373638669" "False" "High" "IsMasterProtein" "Q12907" "Vesicular integral-membrane protein VIP36 OS=Homo sapiens OX=9606 GN=LMAN2 PE=1 SV=1" "0.003" "False" "2.605" "3" "1" "1" "1" "356" "40.2" "6.95" "1.66" "1" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03388" "10960" "ENSG00000169223" "LMAN2" "hsa:10960; Q12907; Q53HH1" "COPII-mediated vesicle transport; Cargo concentration in the ER" "5q35 copy number variation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2850205802309277585" "False" "High" "IsMasterProtein" "Q96DE0" "U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2" "0.003" "False" "2.605" "4" "1" "2" "1" "195" "21.3" "6.89" "5.51" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "131870" "ENSG00000198585" "NUDT16" "B4E3B4; E9PED4; F5GYJ1; hsa:131870; Q96DE0; Q96N82" "Phosphate bond hydrolysis by NUDT proteins" "" "1" "0" "0.809" "0.970" "0.740" "0.787" "0.623" "0.829" "0.866" "1.010" "0.609" "45.9" "37.2" "44.6" "34.0" "36.2" "28.6" "38.1" "39.8" "46.4" "28.0" "" "" "" "" "" "" "" "" "" "" "41.5" "28.7" "34.5" "22.9" "30.2" "24.4" "32.3" "28.8" "31.3" "28.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5593923735961542225" "False" "High" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "0.003" "False" "2.600" "5" "1" "1" "1" "176" "20.7" "6.34" "2.59" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562361449972294003" "False" "High" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "0.003" "False" "2.598" "2" "1" "1" "1" "579" "63.7" "8.87" "2.50" "1" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "" "1" "0" "1.091" "0.802" "1.082" "0.862" "0.900" "0.837" "0.793" "0.915" "2.650" "87.2" "95.1" "69.9" "94.3" "75.1" "78.4" "73.0" "69.1" "79.8" "231.0" "" "" "" "" "" "" "" "" "" "" "78.7" "73.4" "54.1" "63.5" "62.6" "66.9" "61.9" "50.0" "53.8" "231.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760294074974619673" "False" "High" "IsMasterProtein" "O95319" "CUGBP Elav-like family member 2 OS=Homo sapiens OX=9606 GN=CELF2 PE=1 SV=1" "0.003" "False" "2.596" "3" "1" "1" "1" "508" "54.3" "8.76" "2.38" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10659" "ENSG00000048740" "CELF2" "B7ZAN9; O95319; Q7KYU4; Q8N499; Q92950; Q96NW9; Q96RQ5; Q96RQ6; Q9UL67" "" "mRNA processing; Opioid receptor pathways" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043676364934071043" "False" "High" "IsMasterProtein" "Q14254" "Flotillin-2 OS=Homo sapiens OX=9606 GN=FLOT2 PE=1 SV=2" "0.003" "False" "2.595" "2" "1" "1" "1" "428" "47.0" "5.25" "2.96" "1" "cell adhesion;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "" "Pf01145" "2319" "ENSG00000132589" "FLOT2" "hsa:2319; Q14254" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494300980345175756" "False" "High" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "0.003" "False" "2.592" "4" "2" "2" "2" "325" "37.2" "8.05" "5.16" "2" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "Primary focal segmental glomerulosclerosis (FSGS)" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5978102986579792947" "False" "High" "IsMasterProtein" "Q69YL0" "Protein NCBP2AS2 OS=Homo sapiens OX=9606 GN=NCBP2AS2 PE=1 SV=1" "0.003" "False" "2.592" "8" "1" "1" "1" "99" "10.9" "12.00" "2.00" "1" "" "" "" "" "" "ENSG00000270170" "NCBP2AS2" "Q69YL0" "" "3q29 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5281205603675225167" "False" "High" "IsMasterProtein" "Q9NX76" "CKLF-like MARVEL transmembrane domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CMTM6 PE=1 SV=1" "0.003" "False" "2.588" "5" "1" "1" "1" "183" "20.4" "5.29" "2.77" "1" "transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "" "Pf01284" "54918" "ENSG00000091317" "CMTM6" "hsa:54918; Q6IAC4; Q9NX76" "Neutrophil degranulation" "" "1" "0" "1.250" "1.153" "1.521" "1.303" "1.126" "1.047" "1.127" "1.275" "0.938" "29.9" "37.4" "34.5" "45.5" "39.0" "33.7" "31.3" "33.7" "38.1" "28.1" "" "" "" "" "" "" "" "" "" "" "27.0" "28.8" "26.7" "30.6" "32.5" "28.7" "26.5" "24.4" "25.7" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7553626301853439744" "False" "High" "IsMasterProtein" "P63146" "Ubiquitin-conjugating enzyme E2 B OS=Homo sapiens OX=9606 GN=UBE2B PE=1 SV=1" "0.003" "False" "2.583" "8" "1" "1" "1" "152" "17.3" "5.01" "2.17" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00179" "7320" "ENSG00000119048" "UBE2B" "B2R503; D3DQA2; hsa:7320; P23567; P63146; Q4PJ15; Q9D0J6" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Recognition of DNA damage by PCNA-containing replication complex" "Proteasome degradation; Male infertility" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7931724043651333300" "False" "High" "IsMasterProtein" "Q9H3S4" "Thiamine pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=TPK1 PE=1 SV=1" "0.003" "False" "2.578" "4" "1" "1" "1" "243" "27.2" "5.20" "2.50" "1" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf04263, Pf04265" "27010" "ENSG00000196511" "TPK1" "A8K0T7; D3DWG0; hsa:27010; I6L9B8; Q6NUR5; Q9H3S4; Q9H602" "Vitamin B1 (thiamin) metabolism" "Thiamine metabolic pathways" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291846979308804894" "False" "High" "IsMasterProtein" "O95182" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 OS=Homo sapiens OX=9606 GN=NDUFA7 PE=1 SV=3" "0.003" "False" "2.574" "9" "1" "1" "1" "113" "12.5" "10.18" "2.39" "1" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "transporter activity;other molecular function" "Pf07347" "4701" "ENSG00000267855" "NDUFA7" "hsa:4701; O95182" "Complex I biogenesis" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8722569096218095971" "False" "High" "IsMasterProtein" "Q9NVN3" "Synembryn-B OS=Homo sapiens OX=9606 GN=RIC8B PE=1 SV=2" "0.003" "False" "2.572" "2" "1" "1" "1" "520" "58.8" "5.73" "2.65" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf10165" "55188" "ENSG00000111785" "RIC8B" "A2RTZ0; hsa:55188; Q4G103; Q6ZRN4; Q86WD3; Q9NVN3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "748867624032995252" "False" "High" "IsMasterProtein" "Q9H6S3" "Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Homo sapiens OX=9606 GN=EPS8L2 PE=1 SV=2" "0.003" "False" "2.565" "2" "1" "1" "1" "715" "80.6" "6.84" "2.03" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00018, Pf08416, Pf18016" "64787" "ENSG00000177106" "EPS8L2" "B3KSX1; B7ZKL3; hsa:64787; Q53GM8; Q8WYW7; Q96K06; Q9H6K9; Q9H6S3" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "" "2" "0" "1.349" "1.034" "1.246" "1.095" "1.410" "1.182" "1.007" "1.347" "1.225" "17.3" "23.4" "17.9" "21.6" "19.0" "24.4" "20.5" "17.5" "23.3" "21.2" "" "" "" "" "" "" "" "" "" "" "15.7" "18.0" "13.9" "14.6" "15.8" "20.9" "17.4" "12.6" "15.7" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6242890484097416684" "False" "High" "IsMasterProtein" "Q05707" "Collagen alpha-1(XIV) chain OS=Homo sapiens OX=9606 GN=COL14A1 PE=1 SV=3" "0.004" "False" "2.562" "1" "1" "1" "1" "1796" "193.4" "5.30" "3.07" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "extracellular matrix;ER/Golgi;other cell component" "extracellular structural activity;other molecular function" "Pf00041, Pf00092, Pf01391" "7373" "ENSG00000187955" "COL14A1" "B2RU07; hsa:7373; O00260; O00261; O00262; Q05707; Q05708; Q5XJ18; Q96C67; Q9UDF6" "Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization" "" "4" "0" "0.964" "0.677" "0.933" "0.891" "0.811" "0.852" "0.929" "0.667" "0.841" "240.0" "231.2" "162.3" "224.0" "213.9" "194.6" "204.4" "222.9" "160.0" "201.9" "" "" "" "" "" "" "" "" "" "" "216.6" "178.3" "125.6" "150.8" "178.4" "166.1" "173.4" "161.3" "107.9" "201.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1542485656427922063" "False" "High" "IsMasterProtein" "Q6P1K2" "Polyamine-modulated factor 1 OS=Homo sapiens OX=9606 GN=PMF1 PE=1 SV=2" "0.004" "False" "2.552" "4" "1" "1" "1" "205" "23.3" "5.49" "2.17" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03980" "100527963; 11243" "ENSG00000160783" "PMF1" "A8K0C5; hsa:100527963; hsa:11243; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6P1K2; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394977433117342737" "False" "High" "IsMasterProtein" "Q92859" "Neogenin OS=Homo sapiens OX=9606 GN=NEO1 PE=1 SV=2" "0.004" "False" "2.549" "1" "1" "1" "1" "1461" "159.9" "6.54" "2.36" "1" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf06583, Pf07679, Pf13895, Pf13927" "4756" "ENSG00000067141" "NEO1" "B7ZKM9; B7ZKN0; hsa:4756; O00340; Q17RX1; Q92859" "Myogenesis; Netrin-1 signaling" "Splicing factor NOVA regulated synaptic proteins; Netrin-UNC5B signaling pathway; 10q11.21q11.23 copy number variation syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766745797864106974" "False" "High" "IsMasterProtein" "O75528" "Transcriptional adapter 3 OS=Homo sapiens OX=9606 GN=TADA3 PE=1 SV=1" "0.004" "False" "2.546" "3" "1" "1" "1" "432" "48.9" "6.27" "1.79" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10198" "10474" "ENSG00000171148" "TADA3" "hsa:10474; O75528; Q6FI83; Q9UFS2" "Ub-specific processing proteases; Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537965283186170392" "False" "High" "IsMasterProtein" "Q9UM13" "Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1" "0.004" "False" "2.544" "5" "1" "1" "1" "185" "21.2" "9.06" "3.08" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf03256" "10393" "ENSG00000164162" "ANAPC10" "D3DNZ7; hsa:10393; Q2V500; Q9UG51; Q9UM13; Q9Y5R0" "Senescence-Associated Secretory Phenotype (SASP); Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "Cell cycle" "19" "0" "0.844" "0.958" "0.802" "1.082" "0.975" "1.017" "1.069" "1.024" "1.167" "191.1" "161.3" "183.1" "153.3" "206.8" "186.3" "194.2" "204.2" "195.6" "223.0" "" "" "" "" "" "" "" "" "" "" "172.5" "124.4" "141.6" "103.2" "172.5" "159.0" "164.8" "147.8" "131.9" "223.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "809495191273134722" "False" "High" "IsMasterProtein" "P42356" "Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4" "0.004" "False" "2.537" "0" "1" "1" "1" "2102" "236.7" "7.06" "2.49" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf19274" "5297" "ENSG00000241973" "PI4KA" "hsa:5297; P42356; Q7Z625; Q9UPG2" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane" "Ectoderm differentiation; 22q11.2 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4509780979578999144" "False" "High" "IsMasterProtein" "Q8WUX1" "Sodium-coupled neutral amino acid transporter 5 OS=Homo sapiens OX=9606 GN=SLC38A5 PE=1 SV=1" "0.004" "False" "2.537" "2" "1" "1" "1" "472" "51.4" "8.21" "3.20" "1" "transport" "plasma membrane;other membranes" "transporter activity" "Pf01490" "92745" "ENSG00000017483" "SLC38A5" "B3KT20; B5MDE6; B7WPJ9; hsa:92745; Q6PIW9; Q8WUX1; Q8WYU2; Q96PQ4" "Amino acid transport across the plasma membrane" "Neuroinflammation and glutamatergic signaling" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257292579144491246" "False" "High" "IsMasterProtein" "Q92544" "Transmembrane 9 superfamily member 4 OS=Homo sapiens OX=9606 GN=TM9SF4 PE=1 SV=2" "0.004" "False" "2.534" "1" "1" "1" "1" "642" "74.5" "6.54" "2.71" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9777" "ENSG00000101337" "TM9SF4" "B0QYT7; hsa:9777; Q92544; Q9NUA3" "" "" "0" "0" "0.868" "0.859" "0.941" "1.015" "0.719" "0.876" "0.961" "0.998" "0.937" "49.5" "43.0" "42.6" "46.6" "50.3" "35.6" "43.4" "47.6" "49.4" "46.4" "" "" "" "" "" "" "" "" "" "" "44.7" "33.2" "32.9" "31.4" "41.9" "30.4" "36.8" "34.4" "33.3" "46.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752239950939414056" "False" "High" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "0.004" "False" "2.532" "4" "2" "2" "2" "421" "44.9" "7.52" "4.83" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "22q11.2 copy number variation syndrome" "4" "0" "0.969" "0.802" "0.986" "1.038" "0.958" "1.040" "0.856" "0.892" "2.844" "166.4" "161.2" "133.4" "164.1" "172.7" "159.3" "173.0" "142.4" "148.4" "473.0" "" "" "" "" "" "" "" "" "" "" "150.2" "124.3" "103.2" "110.5" "144.1" "136.0" "146.8" "103.0" "100.1" "473.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5064408970215960207" "False" "High" "IsMasterProtein" "Q9C0H2" "Protein tweety homolog 3 OS=Homo sapiens OX=9606 GN=TTYH3 PE=1 SV=3" "0.004" "False" "2.531" "2" "1" "1" "1" "523" "57.5" "5.39" "2.62" "1" "transport" "plasma membrane;other membranes" "transporter activity" "Pf04906" "80727" "ENSG00000136295" "TTYH3" "A4D201; B7WP98; hsa:80727; Q6L749; Q6ZVG3; Q8TEG6; Q9C0H2" "Stimuli-sensing channels" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8730523960052608716" "False" "High" "IsMasterProtein" "O60879" "Protein diaphanous homolog 2 OS=Homo sapiens OX=9606 GN=DIAPH2 PE=1 SV=1" "0.004" "False" "2.530" "1" "1" "1" "1" "1101" "125.5" "6.58" "2.03" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "1730" "ENSG00000147202" "DIAPH2" "A6NG19; hsa:1730; O60878; O60879; Q8WX06; Q8WX48; Q9UJL2" "RHOF GTPase cycle" "Primary ovarian insufficiency" "2" "0" "0.809" "0.672" "0.830" "0.950" "1.047" "1.053" "0.528" "1.061" "2.495" "38.5" "31.1" "25.9" "32.0" "36.6" "40.3" "40.6" "20.3" "40.9" "96.1" "" "" "" "" "" "" "" "" "" "" "34.8" "24.0" "20.0" "21.5" "30.5" "34.4" "34.4" "14.7" "27.6" "96.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5045228690157758775" "False" "High" "IsMasterProtein" "Q9Y4E6" "WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=WDR7 PE=1 SV=2" "0.004" "False" "2.529" "1" "1" "1" "1" "1490" "163.7" "6.92" "3.03" "1" "other biological processes" "other cell component" "" "Pf00400" "23335" "ENSG00000091157" "WDR7" "A7E2C8; hsa:23335; Q86UX5; Q86VP2; Q96PS7; Q9Y4E6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1880581389425643529" "False" "High" "IsMasterProtein" "P19397" "Leukocyte surface antigen CD53 OS=Homo sapiens OX=9606 GN=CD53 PE=1 SV=1" "0.004" "False" "2.517" "4" "1" "1" "1" "219" "24.3" "7.52" "2.75" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00335" "963" "ENSG00000143119" "CD53" "B2R905; hsa:963; P19397; Q5U0D6" "Neutrophil degranulation" "11p11.2 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2116736278876107348" "False" "High" "IsMasterProtein" "Q8IW45" "ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Homo sapiens OX=9606 GN=NAXD PE=1 SV=1" "0.005" "False" "2.515" "2" "1" "1" "1" "347" "36.6" "8.06" "2.23" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01256" "55739" "ENSG00000213995" "NAXD" "B4DXT4; hsa:55739; Q5T9X3; Q8IW45; Q9H7W1; Q9NVF5" "Nicotinamide salvaging" "" "1" "0" "1.222" "0.906" "0.943" "0.967" "1.239" "0.988" "1.049" "1.146" "0.799" "57.9" "70.7" "52.5" "54.6" "56.0" "71.7" "57.2" "60.7" "66.3" "46.3" "" "" "" "" "" "" "" "" "" "" "52.2" "54.5" "40.6" "36.7" "46.7" "61.2" "48.5" "43.9" "44.7" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7272269523816723745" "False" "High" "IsMasterProtein" "Q13613" "Myotubularin-related protein 1 OS=Homo sapiens OX=9606 GN=MTMR1 PE=1 SV=4" "0.005" "False" "2.514" "2" "1" "1" "1" "665" "74.6" "7.14" "2.41" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf02893, Pf06602" "8776" "ENSG00000063601" "MTMR1" "A0A024RC07; hsa:8776; Q13613; Q9UBX6; Q9UEM0; Q9UQD5" "RHOF GTPase cycle; Synthesis of PIPs at the plasma membrane" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8622361133611111311" "False" "High" "IsMasterProtein" "O14936" "Peripheral plasma membrane protein CASK OS=Homo sapiens OX=9606 GN=CASK PE=1 SV=3" "0.005" "False" "2.509" "1" "1" "1" "1" "926" "105.1" "6.43" "3.23" "1" "cell adhesion;other metabolic processes;transport;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00595, Pf00625, Pf02828, Pf07653" "8573" "ENSG00000147044" "CASK" "A6NES1; B7ZKY0; hsa:8573; O14936; O43215; Q17RI4; Q59HA0; Q5VT16; Q5VT17; Q5VT18; Q5VT19; Q66T42; Q9BYH6; Q9NYB2; Q9NYB3" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions" "Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins; Cell lineage map for neuronal differentiation" "10" "0" "0.835" "0.834" "0.983" "0.869" "0.858" "0.854" "0.796" "0.944" "0.795" "165.2" "137.9" "137.7" "162.4" "143.5" "141.7" "141.1" "131.6" "156.0" "131.4" "" "" "" "" "" "" "" "" "" "" "149.1" "106.4" "106.5" "109.3" "119.7" "120.9" "119.7" "95.2" "105.2" "131.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8926153379063192295" "False" "High" "IsMasterProtein" "C9J202" "Putative glycosyltransferase ALG1L2 OS=Homo sapiens OX=9606 GN=ALG1L2 PE=3 SV=1" "0.005" "False" "2.508" "4" "1" "1" "1" "215" "24.1" "5.76" "2.60" "1" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf00534" "644974" "ENSG00000251287" "ALG1L2" "C9J202; hsa:644974" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178274936049826083" "False" "High" "IsMasterProtein" "Q9Y2S2" "Lambda-crystallin homolog OS=Homo sapiens OX=9606 GN=CRYL1 PE=1 SV=3" "0.005" "False" "2.496" "3" "1" "1" "1" "319" "35.4" "6.18" "2.54" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf00725, Pf02737" "51084" "ENSG00000165475" "CRYL1" "A0PJ43; B3KN92; hsa:51084; Q0VDI1; Q7Z4Z9; Q9P0G7; Q9Y2S2" "Formation of xylulose-5-phosphate" "13q12 or CRYL1 copy number variation" "2" "0" "1.362" "1.088" "1.091" "1.246" "1.104" "1.432" "1.237" "0.888" "0.987" "36.6" "49.8" "39.8" "39.9" "45.6" "40.4" "52.4" "45.3" "32.5" "36.1" "" "" "" "" "" "" "" "" "" "" "33.0" "38.4" "30.8" "26.9" "38.0" "34.5" "44.4" "32.8" "21.9" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994823038495086157" "False" "High" "IsMasterProtein" "Q02040" "A-kinase anchor protein 17A OS=Homo sapiens OX=9606 GN=AKAP17A PE=1 SV=2" "0.005" "False" "2.485" "1" "1" "1" "1" "695" "80.7" "9.73" "3.25" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "8227" "ENSG00000197976; ENSG00000292343" "AKAP17A" "hsa:8227; Q02040; Q02832; Q2TB98; Q5JQ74; Q5JQ76; Q8N6U9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3525120211935772800" "False" "High" "IsMasterProtein" "Q9H892" "Tetratricopeptide repeat protein 12 OS=Homo sapiens OX=9606 GN=TTC12 PE=1 SV=2" "0.005" "False" "2.475" "1" "1" "3" "1" "705" "78.7" "5.66" "7.42" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf00515, Pf13181" "54970" "ENSG00000149292" "TTC12" "hsa:54970; Q8N5H9; Q9H892; Q9NWY3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664937440056635092" "False" "High" "IsMasterProtein" "Q9BQ48" "Large ribosomal subunit protein bL34m OS=Homo sapiens OX=9606 GN=MRPL34 PE=1 SV=1" "0.005" "False" "2.463" "13" "1" "1" "1" "92" "10.2" "12.25" "2.92" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00468" "64981" "ENSG00000130312" "MRPL34" "hsa:64981; Q9BQ48" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.410" "1.069" "1.312" "1.413" "1.458" "1.381" "1.131" "1.198" "1.146" "25.0" "35.3" "26.8" "32.8" "35.4" "36.5" "34.6" "28.3" "30.0" "28.7" "" "" "" "" "" "" "" "" "" "" "22.6" "27.2" "20.7" "22.1" "29.5" "31.1" "29.3" "20.5" "20.2" "28.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7234885358333908901" "False" "High" "IsMasterProtein" "O75915" "PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1" "0.005" "False" "2.452" "4" "1" "1" "1" "188" "21.6" "9.77" "2.95" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "" "Pf03208" "10550" "ENSG00000144746" "ARL6IP5" "B2R6V5; hsa:10550; O75915; Q53ES3; Q5KU08" "Glutamate Neurotransmitter Release Cycle" "" "1" "0" "0.895" "0.691" "0.821" "0.830" "0.780" "0.871" "0.900" "0.735" "0.572" "129.5" "115.9" "89.4" "106.3" "107.4" "101.0" "112.7" "116.5" "95.2" "74.1" "" "" "" "" "" "" "" "" "" "" "116.9" "89.4" "69.2" "71.6" "89.6" "86.2" "95.6" "84.3" "64.2" "74.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1136276274869286846" "False" "High" "IsMasterProtein" "Q9NVR2" "Integrator complex subunit 10 OS=Homo sapiens OX=9606 GN=INTS10 PE=1 SV=2" "0.005" "False" "2.449" "1" "1" "1" "1" "710" "82.2" "7.44" "2.72" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf21045" "55174" "ENSG00000104613" "INTS10" "hsa:55174; Q6IA93; Q7L538; Q7L8C8; Q9H3W8; Q9NVR2" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3427861429656696180" "False" "High" "IsMasterProtein" "O95197" "Reticulon-3 OS=Homo sapiens OX=9606 GN=RTN3 PE=1 SV=2" "0.005" "False" "2.449" "1" "1" "1" "1" "1032" "112.5" "4.96" "2.32" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf02453" "10313" "ENSG00000133318" "RTN3" "B3KQS2; B7Z308; B7Z4M0; F5H774; hsa:10313; O95197; Q147U9; Q496K2; Q53GN3; Q59EP0; Q5UEP2; Q6T930; Q7RTM7; Q7RTM8; Q7RTN3" "Synaptic adhesion-like molecules" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2561010377563702326" "False" "High" "IsMasterProtein" "Q8WX92" "Negative elongation factor B OS=Homo sapiens OX=9606 GN=NELFB PE=1 SV=1" "0.005" "False" "2.448" "2" "1" "1" "1" "580" "65.7" "6.13" "2.71" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06209" "25920" "ENSG00000188986" "NELFB" "A0A0X1KG71; A2BFA3; hsa:25920; Q8WX92; Q96EW5; Q9H9R4; Q9ULN8; Q9Y3W0" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; NTRK3 as a dependence receptor" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation; 5q35 copy number variation" "18" "0" "1.232" "1.283" "1.542" "1.220" "0.961" "1.477" "1.183" "0.955" "3.427" "15.8" "19.4" "20.2" "24.3" "19.3" "15.2" "23.3" "18.7" "15.1" "54.1" "" "" "" "" "" "" "" "" "" "" "14.2" "15.0" "15.7" "16.4" "16.1" "12.9" "19.8" "13.5" "10.2" "54.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559199072785365377" "False" "High" "IsMasterProtein" "Q14493" "Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1" "0.005" "False" "2.438" "3" "1" "1" "1" "270" "31.3" "7.47" "2.54" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15247" "7884" "ENSG00000163950" "SLBP" "B3KRJ5; hsa:7884; Q14493" "RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA" "8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8022290740510184659" "False" "High" "IsMasterProtein" "P49257" "Protein ERGIC-53 OS=Homo sapiens OX=9606 GN=LMAN1 PE=1 SV=2" "0.005" "False" "2.435" "2" "1" "1" "1" "510" "57.5" "6.77" "3.13" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03388" "3998" "ENSG00000074695" "LMAN1" "hsa:3998; P49257; Q12895; Q8N5I7; Q9UQG1; Q9UQG2; Q9UQG3; Q9UQG4; Q9UQG5; Q9UQG6; Q9UQG7; Q9UQG8; Q9UQG9; Q9UQH0; Q9UQH1; Q9UQH2" "RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Complement and coagulation cascades" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5456206388273003181" "False" "High" "IsMasterProtein" "O95985" "DNA topoisomerase 3-beta-1 OS=Homo sapiens OX=9606 GN=TOP3B PE=1 SV=1" "0.005" "False" "2.435" "1" "1" "1" "1" "862" "96.6" "8.12" "3.26" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01131, Pf01751" "8940" "ENSG00000100038" "TOP3B" "A0M8Q3; hsa:8940; O95985; Q9BUP5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550223946587707614" "False" "High" "IsMasterProtein" "Q13232" "Nucleoside diphosphate kinase 3 OS=Homo sapiens OX=9606 GN=NME3 PE=1 SV=2" "0.005" "False" "2.433" "10" "1" "1" "1" "169" "19.0" "7.84" "2.11" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00334" "4832" "ENSG00000103024" "NME3" "hsa:4832; Q13232; Q9BWH4" "Interconversion of nucleotide di- and triphosphates" "Pyrimidine metabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5356528915824417311" "False" "High" "IsMasterProtein" "Q7RTS9" "Dymeclin OS=Homo sapiens OX=9606 GN=DYM PE=1 SV=1" "0.006" "False" "2.431" "1" "1" "1" "1" "669" "75.9" "5.86" "3.13" "1" "cell organization and biogenesis;developmental processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf09742" "54808" "ENSG00000141627" "DYM" "A8K5I8; B2RCF9; B4DKI7; hsa:54808; Q3ZTS8; Q6P2P5; Q7RTS9; Q8N2M0; Q9BVE9; Q9NPU7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945913478307562709" "False" "High" "IsMasterProtein" "Q9Y2Q9" "Small ribosomal subunit protein bS1m OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "0.006" "False" "2.418" "5" "1" "1" "1" "187" "20.8" "9.10" "2.29" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765040120545487283" "False" "High" "IsMasterProtein" "Q8IXQ6" "Protein mono-ADP-ribosyltransferase PARP9 OS=Homo sapiens OX=9606 GN=PARP9 PE=1 SV=2" "0.006" "False" "2.405" "1" "1" "1" "1" "854" "96.3" "7.91" "3.30" "1" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01661" "83666" "ENSG00000138496" "PARP9" "A8KA94; B2R8S9; E9PFM7; hsa:83666; Q8IXQ6; Q8TCP3; Q9BZL8; Q9BZL9" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "" "3" "0" "0.760" "0.757" "0.822" "0.815" "0.678" "0.863" "0.697" "0.809" "1.957" "162.8" "123.7" "123.2" "133.8" "132.7" "110.4" "140.5" "113.4" "131.6" "318.6" "" "" "" "" "" "" "" "" "" "" "147.0" "95.4" "95.3" "90.1" "110.7" "94.2" "119.2" "82.1" "88.8" "318.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3823742586445689125" "False" "High" "IsMasterProtein" "Q9NPQ8" "Synembryn-A OS=Homo sapiens OX=9606 GN=RIC8A PE=1 SV=3" "0.006" "False" "2.405" "2" "1" "2" "1" "531" "59.7" "5.33" "5.17" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf10165" "60626" "ENSG00000177963" "RIC8A" "hsa:60626; Q0P508; Q2T9J1; Q7Z352; Q96EZ1; Q96SZ2; Q9H064; Q9H5H3; Q9H9E7; Q9NPQ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1149947407616018825" "False" "High" "IsMasterProtein" "Q9NTX7" "E3 ubiquitin-protein ligase RNF146 OS=Homo sapiens OX=9606 GN=RNF146 PE=1 SV=1" "0.006" "False" "2.403" "4" "1" "1" "1" "359" "38.9" "5.33" "2.04" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02825, Pf13920" "81847" "ENSG00000118518" "RNF146" "E1P572; hsa:81847; Q6FIB2; Q7L8H4; Q96K03; Q96T06; Q9NTX6; Q9NTX7" "Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "Not Found" "Not Found" "Not Found" "High" "High" "Not Found" "High" "1" "" "1307074189875800146" "False" "High" "IsMasterProtein" "O14732" "Inositol monophosphatase 2 OS=Homo sapiens OX=9606 GN=IMPA2 PE=1 SV=1" "0.006" "False" "2.397" "3" "1" "1" "1" "288" "31.3" "6.61" "3.15" "1" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00459" "3613" "ENSG00000141401" "IMPA2" "B0YJ29; hsa:3613; O14732; Q9UJT3" "Synthesis of IP2, IP, and Ins in the cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6959093533306709871" "False" "High" "IsMasterProtein" "P0DPD7" "EEF1A lysine methyltransferase 4 OS=Homo sapiens OX=9606 GN=EEF1AKMT4 PE=1 SV=1" "0.006" "False" "2.394" "3" "1" "1" "1" "255" "28.3" "6.05" "2.43" "1" "other metabolic processes" "" "other molecular function" "Pf08241" "110599564" "ENSG00000284753" "EEF1AKMT4" "A5PLK8; hsa:110599564; O60344; P0DPD7; Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097092162087690863" "False" "High" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "0.006" "False" "2.387" "1" "1" "1" "1" "1085" "122.3" "6.47" "2.55" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "9" "0" "1.265" "0.992" "1.346" "1.264" "0.905" "1.258" "0.961" "0.918" "4.853" "38.5" "48.6" "38.1" "51.7" "48.6" "34.8" "48.4" "36.9" "35.3" "186.6" "" "" "" "" "" "" "" "" "" "" "34.7" "37.5" "29.5" "34.8" "40.5" "29.7" "41.0" "26.7" "23.8" "186.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2673167889447724756" "False" "High" "IsMasterProtein" "Q8IZD4" "mRNA-decapping enzyme 1B OS=Homo sapiens OX=9606 GN=DCP1B PE=1 SV=2" "0.006" "False" "2.370" "1" "1" "1" "1" "617" "67.7" "8.56" "2.53" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "196513" "ENSG00000151065; ENSG00000284850" "DCP1B" "B4DRD1; hsa:196513; Q86XH9; Q8IZD4; Q96BP8; Q96MZ8" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "418728153778102369" "False" "High" "IsMasterProtein" "Q13029" "PR domain zinc finger protein 2 OS=Homo sapiens OX=9606 GN=PRDM2 PE=1 SV=3" "0.006" "False" "2.363" "0" "1" "1" "1" "1718" "188.8" "7.31" "2.79" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912, Pf21549" "7799" "ENSG00000116731" "PRDM2" "B1AJZ4; B5MC68; hsa:7799; Q13029; Q13149; Q14550; Q5THJ1; Q5VUL9" "" "Histone modifications" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1819125433981479748" "False" "High" "IsMasterProtein" "Q15404" "Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3" "0.006" "False" "2.361" "4" "1" "3" "1" "277" "31.5" "8.65" "6.68" "1" "signal transduction;other biological processes" "cytosol;other cell component" "" "Pf13855" "6251" "ENSG00000148484" "RSU1" "A8KA46; D3DRU3; hsa:6251; Q15404; Q6FI17" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "" "1" "0" "0.894" "0.981" "0.801" "0.892" "0.880" "1.036" "0.936" "0.810" "0.866" "61.8" "55.2" "60.6" "49.5" "55.1" "54.3" "64.0" "57.8" "50.0" "53.5" "" "" "" "" "" "" "" "" "" "" "55.8" "42.6" "46.8" "33.3" "45.9" "46.4" "54.3" "41.8" "33.7" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-355832090730620748" "False" "High" "IsMasterProtein" "Q03169" "Tumor necrosis factor alpha-induced protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP2 PE=1 SV=2" "0.006" "False" "2.360" "1" "1" "1" "1" "654" "72.6" "6.46" "3.18" "1" "transport;developmental processes;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf06046" "7127" "ENSG00000185215" "TNFAIP2" "hsa:7127; Q03169; Q86VI0" "" "IL-18 signaling pathway" "1" "0" "0.941" "0.898" "0.890" "1.010" "0.884" "1.116" "0.996" "0.852" "0.779" "204.6" "192.5" "183.8" "182.1" "206.6" "180.8" "228.3" "203.8" "174.4" "159.4" "" "" "" "" "" "" "" "" "" "" "184.7" "148.5" "142.1" "122.6" "172.3" "154.3" "193.7" "147.5" "117.6" "159.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1411281452547832793" "False" "High" "IsMasterProtein" "Q9UPT9" "Ubiquitin carboxyl-terminal hydrolase 22 OS=Homo sapiens OX=9606 GN=USP22 PE=1 SV=2" "0.006" "False" "2.359" "2" "1" "1" "1" "525" "59.9" "8.05" "2.49" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00443, Pf02148" "23326" "ENSG00000124422" "USP22" "A0JNS3; hsa:23326; Q2NLE2; Q6MZY4; Q8TBS8; Q96IW5; Q9UPT9" "Ub-specific processing proteases; HATs acetylate histones" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601999827614054718" "False" "High" "IsMasterProtein" "O95067" "G2/mitotic-specific cyclin-B2 OS=Homo sapiens OX=9606 GN=CCNB2 PE=1 SV=1" "0.006" "False" "2.358" "2" "1" "1" "1" "398" "45.3" "8.90" "2.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "9133" "ENSG00000157456" "CCNB2" "B3KM93; hsa:9133; O95067; Q6FI99" "Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8048887560610190463" "False" "High" "IsMasterProtein" "Q5JPH6" "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial OS=Homo sapiens OX=9606 GN=EARS2 PE=1 SV=2" "0.006" "False" "2.354" "2" "1" "1" "1" "523" "58.7" "8.76" "3.27" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00749, Pf19269" "124454" "ENSG00000103356" "EARS2" "B3KTT2; D3DWF1; hsa:124454; Q5JPH6; Q86YH3; Q8TF31" "Mitochondrial tRNA aminoacylation" "" "1" "0" "0.890" "1.138" "1.000" "1.025" "1.234" "1.179" "0.965" "1.233" "5.742" "27.1" "24.1" "30.8" "27.1" "27.8" "33.4" "31.9" "26.1" "33.4" "155.5" "" "" "" "" "" "" "" "" "" "" "24.4" "18.6" "23.8" "18.2" "23.2" "28.5" "27.1" "18.9" "22.5" "155.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787657634019778386" "False" "High" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "0.006" "False" "2.353" "3" "1" "1" "1" "248" "27.6" "5.30" "2.28" "1" "other metabolic processes" "" "other molecular function" "Pf00657" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "0.972" "1.085" "0.887" "0.938" "1.219" "0.883" "1.065" "1.018" "0.614" "65.1" "63.3" "70.7" "57.8" "61.1" "79.4" "57.5" "69.3" "66.3" "40.0" "" "" "" "" "" "" "" "" "" "" "58.8" "48.9" "54.7" "38.9" "51.0" "67.8" "48.8" "50.2" "44.7" "40.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1796554414882976290" "False" "High" "IsMasterProtein" "Q8TCG1" "Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2" "0.006" "False" "2.348" "1" "1" "2" "1" "905" "102.1" "6.23" "4.47" "1" "cell organization and biogenesis;stress response" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf21044" "57650" "ENSG00000163507" "CIP2A" "A1L4J7; B9EGC3; hsa:57650; Q6P4G6; Q8TCG1; Q8WVP8; Q96PI2; Q9H9C6; Q9P204" "" "Netrin-UNC5B signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058361017873513588" "False" "High" "IsMasterProtein" "P63173" "Large ribosomal subunit protein eL38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "0.006" "False" "2.339" "10" "1" "3" "1" "70" "8.2" "10.10" "7.50" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "16" "0" "1.002" "1.436" "1.098" "0.900" "1.279" "1.113" "1.162" "1.208" "0.345" "30.4" "30.4" "43.6" "33.4" "27.3" "38.8" "33.8" "35.3" "36.7" "10.5" "" "" "" "" "" "" "" "" "" "" "27.4" "23.5" "33.7" "22.5" "22.8" "33.1" "28.7" "25.5" "24.7" "10.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502838028789951010" "False" "High" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "0.006" "False" "2.328" "8" "1" "1" "1" "102" "11.2" "9.32" "2.63" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209502681101224333" "False" "High" "IsMasterProtein" "Q9NV96" "Cell cycle control protein 50A OS=Homo sapiens OX=9606 GN=TMEM30A PE=1 SV=1" "0.006" "False" "2.321" "2" "1" "1" "1" "361" "40.7" "8.59" "2.53" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03381" "55754" "ENSG00000112697" "TMEM30A" "A8K9V8; E1P539; hsa:55754; Q658Z3; Q96H09; Q9NSL9; Q9NV96" "Neutrophil degranulation" "" "1" "0" "1.094" "1.153" "1.284" "1.202" "0.978" "1.104" "0.985" "1.124" "1.054" "71.0" "77.6" "81.8" "91.1" "85.3" "69.4" "78.4" "69.9" "79.8" "74.8" "" "" "" "" "" "" "" "" "" "" "64.1" "59.9" "63.3" "61.4" "71.2" "59.2" "66.5" "50.6" "53.8" "74.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8182350314247288702" "False" "High" "IsMasterProtein" "Q9NVQ4" "Fas apoptotic inhibitory molecule 1 OS=Homo sapiens OX=9606 GN=FAIM PE=1 SV=1" "0.006" "False" "2.312" "4" "1" "2" "1" "179" "20.2" "5.83" "5.52" "1" "signal transduction;other biological processes" "other cell component" "" "Pf06905" "55179" "ENSG00000158234" "FAIM" "hsa:55179; Q6IAN2; Q9NVQ4" "" "Neurogenesis regulation in the olfactory epithelium" "1" "0" "0.931" "0.993" "1.113" "0.957" "0.801" "1.026" "0.939" "1.029" "2.273" "101.0" "94.1" "100.3" "112.4" "96.6" "81.0" "103.7" "94.8" "103.9" "229.6" "" "" "" "" "" "" "" "" "" "" "91.2" "72.5" "77.6" "75.7" "80.6" "69.1" "87.9" "68.6" "70.1" "229.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4144599890288946510" "False" "High" "IsMasterProtein" "O15480" "Melanoma-associated antigen B3 OS=Homo sapiens OX=9606 GN=MAGEB3 PE=1 SV=2" "0.006" "False" "2.311" "4" "1" "2" "1" "346" "39.2" "10.07" "3.94" "1" "other biological processes" "nucleus" "" "Pf01454, Pf12440" "4114" "ENSG00000198798" "MAGEB3" "A0AVE4; B3KQ52; hsa:4114; O15480; O75861" "" "" "0" "0" "0.970" "0.877" "0.878" "0.936" "1.163" "0.723" "1.033" "1.113" "0.860" "218.7" "212.1" "191.8" "192.1" "204.7" "254.3" "158.2" "225.9" "243.3" "188.0" "" "" "" "" "" "" "" "" "" "" "197.4" "163.6" "148.3" "129.3" "170.7" "217.1" "134.2" "163.5" "164.1" "188.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7253720687934924150" "False" "High" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "0.006" "False" "2.311" "1" "1" "1" "1" "551" "62.1" "8.40" "2.69" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "ISG15 antiviral mechanism; PKR-mediated signaling; Interferon alpha/beta signaling; Evasion by RSV of host interferon responses; Inhibition of PKR; SUMOylation of immune response proteins" "Translation factors; Alzheimer's disease and miRNA effects; PDGFR-beta pathway; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7231922059350436850" "False" "High" "IsMasterProtein" "Q9P1W9" "Serine/threonine-protein kinase pim-2 OS=Homo sapiens OX=9606 GN=PIM2 PE=1 SV=1" "0.006" "False" "2.311" "3" "1" "1" "1" "311" "34.2" "5.92" "3.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069" "11040" "ENSG00000102096; ENSG00000292210" "PIM2" "A8K4G6; hsa:11040; Q99739; Q9P1W9" "" "Imatinib and chronic myeloid leukemia; Translation inhibitors in chronically activated PDGFRA cells; Acute myeloid leukemia" "3" "0" "0.966" "0.863" "1.093" "1.204" "0.857" "1.058" "1.072" "0.802" "2.019" "100.9" "97.5" "87.1" "110.3" "121.4" "86.5" "106.7" "108.1" "80.9" "203.7" "" "" "" "" "" "" "" "" "" "" "91.1" "75.2" "67.4" "74.2" "101.3" "73.8" "90.6" "78.2" "54.5" "203.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-499196435734005468" "False" "High" "IsMasterProtein" "Q96GJ1" "tRNA (uracil-5-)-methyltransferase homolog B OS=Homo sapiens OX=9606 GN=TRMT2B PE=1 SV=1" "0.006" "False" "2.307" "2" "1" "1" "1" "504" "56.4" "8.81" "2.14" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf05958" "79979" "ENSG00000188917" "TRMT2B" "A6NDG5; A6NEI9; A6NMG6; hsa:79979; Q5JPF0; Q5JVY6; Q96GJ1; Q96HU7; Q96IH9; Q9H9K2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776165374606149247" "False" "High" "IsMasterProtein" "Q99547" "M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2" "0.006" "False" "2.301" "5" "1" "1" "1" "160" "19.0" "5.20" "2.63" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf10175" "10200" "ENSG00000135698" "MPHOSPH6" "B2RAF0; hsa:10200; Q99547" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2125908269399926840" "False" "High" "IsMasterProtein" "Q9UKK3" "Protein mono-ADP-ribosyltransferase PARP4 OS=Homo sapiens OX=9606 GN=PARP4 PE=1 SV=3" "0.006" "False" "2.295" "1" "1" "1" "1" "1724" "192.5" "5.66" "3.34" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00092, Pf00533, Pf00644, Pf08487" "143" "ENSG00000102699" "PARP4" "hsa:143; O75903; Q14682; Q5QNZ9; Q9H1M6; Q9UKK3" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3491083928038066110" "False" "High" "IsMasterProtein" "Q9NZM5" "Ribosome biogenesis protein NOP53 OS=Homo sapiens OX=9606 GN=NOP53 PE=1 SV=2" "0.006" "False" "2.291" "2" "1" "1" "1" "478" "54.4" "10.32" "2.55" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07767" "29997" "ENSG00000105373" "NOP53" "hsa:29997; Q9BTC6; Q9HAX6; Q9NPP1; Q9NPR4; Q9NZM5; Q9UFI2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1550245044930584374" "False" "High" "IsMasterProtein" "O60583" "Cyclin-T2 OS=Homo sapiens OX=9606 GN=CCNT2 PE=1 SV=2" "0.006" "False" "2.290" "1" "1" "1" "1" "730" "81.0" "8.92" "2.63" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "905" "ENSG00000082258" "CCNT2" "A8KA48; D3DP73; D3DP74; hsa:905; O60582; O60583; Q29R66; Q53SR4; Q5I1Y0" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "Male infertility" "10" "0" "1.155" "0.926" "1.074" "1.288" "1.055" "1.019" "1.149" "0.999" "1.361" "124.6" "143.9" "115.4" "133.8" "160.5" "131.5" "127.0" "143.1" "124.5" "169.5" "" "" "" "" "" "" "" "" "" "" "112.5" "111.0" "89.2" "90.1" "133.8" "112.2" "107.7" "103.6" "84.0" "169.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3347831162215749093" "False" "High" "IsMasterProtein" "Q9UEW8" "STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3" "0.006" "False" "2.289" "2" "1" "1" "1" "545" "59.4" "6.29" "2.43" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "27347" "ENSG00000198648" "STK39" "O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; Q9UEW8; X5D9C8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527103595491136930" "False" "High" "IsMasterProtein" "Q9H2H9" "Sodium-coupled neutral amino acid symporter 1 OS=Homo sapiens OX=9606 GN=SLC38A1 PE=1 SV=1" "0.006" "False" "2.288" "2" "1" "1" "1" "487" "54.0" "7.02" "2.48" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf01490" "81539" "ENSG00000111371" "SLC38A1" "hsa:81539; Q8NC61; Q8NCF8; Q96JX2; Q9H2H9; Q9H2Q2" "Amino acid transport across the plasma membrane; Astrocytic Glutamate-Glutamine Uptake And Metabolism" "Synaptic vesicle pathway; Ferroptosis; Neuroinflammation and glutamatergic signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8147219015132361751" "False" "High" "IsMasterProtein" "Q96A19" "Coiled-coil domain-containing protein 102A OS=Homo sapiens OX=9606 GN=CCDC102A PE=1 SV=2" "0.006" "False" "2.285" "2" "1" "1" "1" "550" "62.6" "5.58" "2.98" "1" "" "cytoskeleton" "" "Pf01576" "92922" "ENSG00000135736" "CCDC102A" "hsa:92922; Q96A19; Q9BT74" "" "" "0" "0" "0.923" "0.856" "0.987" "0.859" "1.031" "0.982" "0.975" "0.884" "0.783" "73.9" "68.2" "63.3" "72.9" "63.5" "76.2" "72.6" "72.1" "65.3" "57.9" "" "" "" "" "" "" "" "" "" "" "66.7" "52.6" "49.0" "49.1" "53.0" "65.1" "61.6" "52.2" "44.0" "57.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5363989837697164567" "False" "High" "IsMasterProtein" "Q9Y4C2" "TRPM8 channel-associated factor 1 OS=Homo sapiens OX=9606 GN=TCAF1 PE=1 SV=3" "0.006" "False" "2.282" "1" "1" "1" "1" "921" "102.1" "6.54" "0.00" "1" "other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13402, Pf17291" "9747" "ENSG00000198420" "TCAF1" "A8K6E0; hsa:9747; Q75KM8; Q75KM9; Q7L665; Q9BW63; Q9Y4C2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1352490875980109709" "False" "High" "IsMasterProtein" "Q5VVQ6" "Ubiquitin thioesterase OTU1 OS=Homo sapiens OX=9606 GN=YOD1 PE=1 SV=1" "0.006" "False" "2.280" "3" "1" "1" "1" "348" "38.3" "6.11" "2.59" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02338, Pf21403" "55432" "ENSG00000180667" "YOD1" "B2RNX3; hsa:55432; Q5VVQ5; Q5VVQ6; Q6ZRS6; Q86T63; Q9P1L8" "Ovarian tumor domain proteases" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5067244968494119358" "False" "High" "IsMasterProtein" "O75496" "Geminin OS=Homo sapiens OX=9606 GN=GMNN PE=1 SV=1" "0.007" "False" "2.279" "3" "1" "1" "1" "209" "23.6" "4.96" "3.15" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07412" "51053" "ENSG00000112312" "GMNN" "B3KMM8; hsa:51053; O75496; Q9H1Z1" "Assembly of the pre-replicative complex; Activation of the pre-replicative complex; Switching of origins to a post-replicative state" "DNA replication; DYRK1A involvement regarding cell proliferation in brain development" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7065461624018501642" "False" "High" "IsMasterProtein" "Q96JB5" "CDK5 regulatory subunit-associated protein 3 OS=Homo sapiens OX=9606 GN=CDK5RAP3 PE=1 SV=2" "0.007" "False" "2.279" "2" "1" "1" "1" "506" "56.9" "4.75" "2.60" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05600" "80279" "ENSG00000108465" "CDK5RAP3" "B7Z6N4; D3DTU1; D3DTU2; F5H3I5; hsa:80279; Q53FA2; Q96JB5; Q9H3F8; Q9H8G0; Q9HBR9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "262985657933925195" "False" "High" "IsMasterProtein" "Q969H6" "Ribonuclease P/MRP protein subunit POP5 OS=Homo sapiens OX=9606 GN=POP5 PE=1 SV=1" "0.007" "False" "2.277" "7" "1" "2" "1" "163" "18.8" "7.27" "2.28" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "51367" "ENSG00000167272" "POP5" "A6NL80; hsa:51367; Q53FS5; Q969H6; Q9Y2Q6" "tRNA processing in the nucleus" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187595421119904315" "False" "High" "IsMasterProtein" "Q96K31" "Uncharacterized protein C8orf76 OS=Homo sapiens OX=9606 GN=C8orf76 PE=1 SV=1" "0.007" "False" "2.275" "2" "1" "1" "1" "380" "43.2" "5.43" "2.22" "1" "" "" "" "Pf17826" "84933" "ENSG00000189376" "C8orf76" "hsa:84933; Q53HC1; Q96K31" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4927987348987010712" "False" "High" "IsMasterProtein" "P35790" "Choline kinase alpha OS=Homo sapiens OX=9606 GN=CHKA PE=1 SV=3" "0.007" "False" "2.272" "2" "1" "1" "1" "457" "52.2" "6.55" "2.62" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1119" "ENSG00000110721" "CHKA" "hsa:1119; P35790; Q8NE29" "Synthesis of PC; Synthesis of PE" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Acetylcholine synthesis" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1549161421235899806" "False" "High" "IsMasterProtein" "Q96EH3" "Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1" "0.007" "False" "2.270" "3" "1" "2" "1" "234" "26.2" "5.49" "6.28" "1" "other biological processes" "cytosol;mitochondrion" "translation activity" "Pf02410" "115416" "ENSG00000156928" "MALSU1" "A4D154; hsa:115416; Q96EH3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6046703873344704710" "False" "High" "IsMasterProtein" "Q9H1D9" "DNA-directed RNA polymerase III subunit RPC6 OS=Homo sapiens OX=9606 GN=POLR3F PE=1 SV=1" "0.007" "False" "2.266" "3" "1" "1" "1" "316" "35.7" "6.11" "2.12" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05158" "10621" "ENSG00000132664" "POLR3F" "A8K4C7; hsa:10621; O15319; Q9H1D9" "Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "10" "0" "0.966" "0.645" "0.963" "0.861" "1.106" "1.136" "1.010" "0.822" "0.921" "43.3" "41.8" "27.9" "41.6" "37.3" "47.8" "49.1" "43.7" "35.6" "39.8" "" "" "" "" "" "" "" "" "" "" "39.0" "32.2" "21.6" "28.0" "31.1" "40.8" "41.7" "31.6" "24.0" "39.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058846499056220573" "False" "High" "IsMasterProtein" "Q96CP2" "FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1" "0.007" "False" "2.257" "8" "1" "1" "1" "140" "14.6" "8.46" "2.70" "1" "" "" "" "Pf15423" "114984" "ENSG00000162076" "FLYWCH2" "hsa:114984; Q96CP2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5993686438301718268" "False" "High" "IsMasterProtein" "Q96P11" "28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2" "0.007" "False" "2.248" "3" "1" "1" "1" "429" "46.7" "8.62" "2.24" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf21148, Pf21153" "55695" "ENSG00000130305" "NSUN5" "B3KX04; B4DP79; G3V0G9; hsa:55695; Q6ZUI8; Q96HT9; Q96P11; Q9NW70" "" "" "0" "0" "1.101" "1.363" "1.206" "1.243" "1.099" "1.306" "1.334" "1.323" "1.207" "55.8" "61.4" "76.0" "67.3" "69.4" "61.3" "72.9" "74.4" "73.8" "67.3" "" "" "" "" "" "" "" "" "" "" "50.4" "47.4" "58.8" "45.3" "57.9" "52.3" "61.8" "53.8" "49.8" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7080183333196327832" "False" "High" "IsMasterProtein" "Q86X95" "Corepressor interacting with RBPJ 1 OS=Homo sapiens OX=9606 GN=CIR1 PE=1 SV=1" "0.007" "False" "2.246" "2" "1" "1" "1" "450" "52.3" "9.86" "2.65" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10197" "9541" "ENSG00000138433" "CIR1" "A6NFI6; A8K8M4; hsa:9541; O95367; Q12804; Q4G1B9; Q6PJI4; Q86X95; Q8IWI2" "" "Notch signaling pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2492385812914646204" "False" "High" "IsMasterProtein" "O14730" "Serine/threonine-protein kinase RIO3 OS=Homo sapiens OX=9606 GN=RIOK3 PE=1 SV=2" "0.007" "False" "2.243" "2" "1" "1" "1" "519" "59.1" "5.76" "2.61" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01163" "8780" "ENSG00000101782" "RIOK3" "O14730; Q8IXN9" "Major pathway of rRNA processing in the nucleolus and cytosol" "Hematopoietic stem cell differentiation" "2" "0" "0.942" "1.060" "0.911" "1.144" "1.071" "0.881" "1.206" "1.028" "0.784" "56.6" "53.3" "60.0" "51.6" "64.8" "60.6" "49.9" "68.3" "58.2" "44.4" "" "" "" "" "" "" "" "" "" "" "51.1" "41.1" "46.4" "34.7" "54.0" "51.7" "42.3" "49.4" "39.2" "44.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7957513769242835484" "False" "High" "IsMasterProtein" "Q9Y5S1" "Transient receptor potential cation channel subfamily V member 2 OS=Homo sapiens OX=9606 GN=TRPV2 PE=1 SV=1" "0.007" "False" "2.238" "1" "1" "1" "1" "764" "85.9" "5.83" "2.06" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00520, Pf12796" "51393" "ENSG00000187688" "TRPV2" "A6NML2; A8K0Z0; hsa:51393; Q9Y5S1; Q9Y670" "TRP channels" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7473966995224482536" "False" "High" "IsMasterProtein" "Q13233" "Mitogen-activated protein kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP3K1 PE=1 SV=4" "0.007" "False" "2.238" "1" "1" "1" "1" "1512" "164.4" "7.74" "2.50" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf04434, Pf21040" "4214" "ENSG00000095015" "MAP3K1" "hsa:4214; Q13233" "MyD88:MAL(TIRAP) cascade initiated on plasma membrane; FCERI mediated MAPK activation; TRAF6 mediated NF-kB activation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane" "IL-1 signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Oxidative damage response; PDGFR-beta pathway; p38 MAPK signaling pathway; MAPK cascade; EGF/EGFR signaling pathway; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Hepatitis B infection; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "32" "0" "0.878" "1.277" "0.896" "0.939" "1.240" "0.903" "0.894" "1.181" "1.400" "93.5" "82.0" "119.4" "83.7" "87.8" "115.9" "84.4" "83.6" "110.4" "130.9" "" "" "" "" "" "" "" "" "" "" "84.4" "63.3" "92.3" "56.4" "73.2" "98.9" "71.6" "60.5" "74.5" "130.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2935309689569447405" "False" "High" "IsMasterProtein" "Q9BYD6" "Large ribosomal subunit protein uL1m OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2" "0.007" "False" "2.233" "2" "1" "1" "1" "325" "36.9" "8.78" "3.01" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00687" "65008" "ENSG00000169288" "MRPL1" "A6NG03; hsa:65008; Q4W5B8; Q6IAG4; Q96BW3; Q9BYD6; Q9H793; Q9NRL5" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4179257016855703776" "False" "High" "IsMasterProtein" "Q53QV2" "Protein LBH OS=Homo sapiens OX=9606 GN=LBH PE=1 SV=1" "0.007" "False" "2.233" "18" "1" "1" "1" "105" "12.2" "4.41" "2.64" "1" "other biological processes" "nucleus;other cell component" "" "Pf15317" "81606" "ENSG00000213626" "LBH" "B2RBC2; hsa:81606; Q53QV2; Q9H0Q1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2271404358644786379" "False" "High" "IsMasterProtein" "P46778" "Large ribosomal subunit protein eL21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2" "0.007" "False" "2.229" "4" "1" "1" "1" "160" "18.6" "10.49" "2.92" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf01157" "6144" "ENSG00000122026" "RPL21" "hsa:6144; P46778; Q16699" "Major pathway of rRNA processing in the nucleolus and cytosol; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777043105444546084" "False" "High" "IsMasterProtein" "P00387" "NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3" "0.007" "False" "2.227" "3" "1" "1" "1" "301" "34.2" "7.59" "3.60" "1" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00175, Pf00970" "1727" "ENSG00000100243" "CYB5R3" "B1AHF2; B7Z7L3; hsa:1727; O75675; P00387; Q8TDL8; Q8WTS8; Q9UEN4; Q9UEN5; Q9UL55; Q9UL56" "Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism" "Oxidation by cytochrome P450" "4" "0" "0.864" "0.948" "0.994" "0.856" "0.832" "1.072" "0.984" "0.934" "0.809" "133.7" "115.5" "126.7" "132.9" "114.4" "111.3" "143.3" "131.6" "124.9" "108.2" "" "" "" "" "" "" "" "" "" "" "120.7" "89.1" "98.0" "89.5" "95.4" "95.0" "121.6" "95.2" "84.2" "108.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7917199320651257178" "False" "High" "IsMasterProtein" "P53801" "Pituitary tumor-transforming gene 1 protein-interacting protein OS=Homo sapiens OX=9606 GN=PTTG1IP PE=1 SV=1" "0.007" "False" "2.221" "4" "1" "1" "1" "180" "20.3" "8.79" "2.88" "1" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "" "754" "ENSG00000183255" "PTTG1IP" "B2RDP7; D3DSL9; hsa:754; P53801; Q9NS09" "" "" "0" "0" "0.997" "1.130" "0.901" "1.208" "1.183" "1.181" "1.040" "1.128" "0.825" "113.1" "112.7" "127.8" "101.9" "136.6" "133.8" "133.5" "117.6" "127.6" "93.2" "" "" "" "" "" "" "" "" "" "" "102.1" "86.9" "98.8" "68.6" "114.0" "114.2" "113.3" "85.1" "86.1" "93.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "921315881662704994" "False" "High" "IsMasterProtein" "O15040" "Tectonin beta-propeller repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=TECPR2 PE=1 SV=4" "0.007" "False" "2.219" "1" "1" "1" "1" "1411" "153.8" "5.55" "2.34" "1" "other metabolic processes;transport" "other cell component" "" "Pf06462, Pf19193" "9895" "ENSG00000196663" "TECPR2" "A5PKY3; A6NFY9; A7E2X3; H0YMM9; hsa:9895; O15040; Q9UEG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1838412941252019118" "False" "High" "IsMasterProtein" "Q9Y530" "ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2" "0.007" "False" "2.211" "5" "1" "1" "1" "152" "17.0" "8.31" "2.37" "1" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf01661" "221443" "ENSG00000124596" "OARD1" "A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766075774548217970" "False" "High" "IsMasterProtein" "Q8IW19" "Aprataxin and PNK-like factor OS=Homo sapiens OX=9606 GN=APLF PE=1 SV=1" "0.007" "False" "2.211" "2" "1" "1" "1" "511" "56.9" "5.08" "2.55" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10283, Pf17913" "200558" "ENSG00000169621" "APLF" "A8K476; hsa:200558; Q53P47; Q53PB9; Q53QU0; Q8IW19" "" "" "0" "0" "0.996" "0.814" "1.055" "0.858" "0.795" "1.398" "0.851" "1.089" "1.404" "21.3" "21.2" "17.3" "22.5" "18.3" "16.9" "29.8" "18.1" "23.2" "29.9" "" "" "" "" "" "" "" "" "" "" "19.2" "16.4" "13.4" "15.1" "15.2" "14.5" "25.2" "13.1" "15.6" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144980634344963458" "False" "High" "IsMasterProtein" "O14686" "Histone-lysine N-methyltransferase 2D OS=Homo sapiens OX=9606 GN=KMT2D PE=1 SV=2" "0.007" "False" "2.209" "0" "1" "1" "1" "5537" "593.0" "5.58" "2.73" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "8085" "ENSG00000167548" "KMT2D" "hsa:8085; O14686; O14687" "Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "Histone modifications; 16p11.2 proximal deletion syndrome" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1391272447933749932" "False" "High" "IsMasterProtein" "Q9UNI6" "Dual specificity protein phosphatase 12 OS=Homo sapiens OX=9606 GN=DUSP12 PE=1 SV=1" "0.007" "False" "2.208" "3" "1" "1" "1" "340" "37.7" "6.84" "2.86" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00782" "11266" "ENSG00000081721" "DUSP12" "hsa:11266; Q5VXA8; Q9UNI6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1822880503447006764" "False" "High" "IsMasterProtein" "Q9NX04" "AFG2-interacting ribosome maturation factor OS=Homo sapiens OX=9606 GN=AIRIM PE=1 SV=1" "0.007" "False" "2.206" "4" "1" "1" "1" "203" "23.4" "5.67" "2.81" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf15011" "54955" "ENSG00000116922" "AIRIM" "D3DPT1; Q8WVD1; Q9NX04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6450928307981678161" "False" "High" "IsMasterProtein" "A4D2B0" "Metallo-beta-lactamase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MBLAC1 PE=1 SV=1" "0.007" "False" "2.191" "5" "1" "2" "1" "266" "27.2" "4.86" "4.22" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00753" "255374" "ENSG00000214309" "MBLAC1" "A4D2B0; hsa:255374; Q8N5X8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2689807764461259151" "False" "High" "IsMasterProtein" "P22001" "Potassium voltage-gated channel subfamily A member 3 OS=Homo sapiens OX=9606 GN=KCNA3 PE=1 SV=3" "0.008" "False" "2.186" "1" "1" "1" "1" "575" "63.8" "5.87" "3.43" "1" "cell organization and biogenesis;transport;developmental processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00520, Pf02214" "3738" "ENSG00000177272" "KCNA3" "hsa:3738; P22001; Q5VWN2" "Voltage gated Potassium channels" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1632540778200031519" "False" "High" "IsMasterProtein" "Q9BVA0" "Katanin p80 WD40 repeat-containing subunit B1 OS=Homo sapiens OX=9606 GN=KATNB1 PE=1 SV=1" "0.008" "False" "2.186" "2" "1" "1" "1" "655" "72.3" "7.56" "2.23" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf13925" "10300" "ENSG00000140854" "KATNB1" "A6NCG6; hsa:10300; O60620; Q9BVA0" "" "Genes related to primary cilium development (based on CRISPR)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316205606070741097" "False" "High" "IsMasterProtein" "Q5JTD0" "Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1" "0.008" "False" "2.182" "2" "1" "1" "1" "557" "61.8" "5.97" "1.94" "1" "cell organization and biogenesis" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf15453" "93643" "ENSG00000137221" "TJAP1" "hsa:93643; Q05BH9; Q5JTD0; Q5JTD1; Q5JWW1; Q68DB2; Q6P2P3; Q9H7V7" "" "" "0" "0" "0.889" "0.887" "0.996" "0.868" "0.685" "0.766" "0.845" "0.732" "1.173" "25.4" "22.6" "22.6" "25.3" "22.1" "17.4" "19.5" "21.5" "18.6" "29.8" "" "" "" "" "" "" "" "" "" "" "22.9" "17.4" "17.4" "17.0" "18.4" "14.8" "16.5" "15.5" "12.5" "29.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480743538418204073" "False" "High" "IsMasterProtein" "Cont_P02777" "Platelet factor 4 OS=Bos taurus OX=9913 GN=PF4 PE=1 SV=1" "0.008" "True" "2.180" "9" "1" "1" "1" "88" "9.5" "6.52" "2.99" "1" "stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00048" "" "" "PF4" "P02777" "" "" "0" "0" "0.844" "0.776" "0.895" "0.890" "0.721" "0.851" "1.244" "0.699" "0.578" "143.9" "121.5" "111.7" "128.8" "128.0" "103.7" "122.4" "179.1" "100.6" "83.2" "" "" "" "" "" "" "" "" "" "" "129.9" "93.7" "86.4" "86.7" "106.8" "88.5" "103.8" "129.6" "67.9" "83.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7132553212983822246" "False" "High" "IsMasterProtein" "P08174" "Complement decay-accelerating factor OS=Homo sapiens OX=9606 GN=CD55 PE=1 SV=4" "0.008" "False" "2.178" "2" "1" "1" "1" "381" "41.4" "7.59" "2.74" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00084" "1604" "ENSG00000196352" "CD55" "B1AP14; D3DT83; D3DT84; E7ER69; hsa:1604; P08174; P09679; P78361; Q14UF2; Q14UF3; Q14UF4; Q14UF5; Q14UF6" "COPI-mediated anterograde transport; Regulation of Complement cascade; Neutrophil degranulation; Class B/2 (Secretin family receptors)" "Allograft rejection; Complement system; Dengue-2 interactions with complement and coagulation cascades; Acute viral myocarditis; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades" "11" "0" "0.949" "0.958" "1.033" "1.045" "1.101" "0.953" "1.261" "0.997" "1.493" "80.5" "76.4" "77.1" "83.1" "84.1" "88.6" "76.7" "101.5" "80.2" "120.1" "" "" "" "" "" "" "" "" "" "" "72.7" "58.9" "59.7" "56.0" "70.1" "75.6" "65.1" "73.5" "54.1" "120.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826640121646055106" "False" "High" "IsMasterProtein" "P13473" "Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2" "0.008" "False" "2.176" "2" "1" "1" "1" "410" "44.9" "5.63" "2.67" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3920" "ENSG00000005893" "LAMP2" "A8K4X5; D3DTF0; hsa:3920; P13473; Q16641; Q6Q3G8; Q96J30; Q99534; Q9UD93" "Neutrophil degranulation; Platelet degranulation ; Chaperone Mediated Autophagy" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Clock-controlled autophagy in bone metabolism" "5" "0" "0.955" "1.029" "1.046" "0.886" "1.123" "0.960" "0.829" "1.295" "0.718" "47.0" "44.9" "48.4" "49.2" "41.7" "52.8" "45.1" "39.0" "60.9" "33.8" "" "" "" "" "" "" "" "" "" "" "42.5" "34.6" "37.4" "33.1" "34.8" "45.1" "38.3" "28.2" "41.1" "33.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178980302497891247" "False" "High" "IsMasterProtein" "P29597" "Non-receptor tyrosine-protein kinase TYK2 OS=Homo sapiens OX=9606 GN=TYK2 PE=1 SV=3" "0.008" "False" "2.175" "1" "1" "1" "1" "1187" "133.6" "7.15" "2.56" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714, Pf17887, Pf18377, Pf18379" "7297" "ENSG00000105397" "TYK2" "hsa:7297; P29597; Q6QB10; Q96CH0" "Potential therapeutics for SARS; Interleukin-4 and Interleukin-13 signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Interleukin-10 signaling; Interleukin-6 signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; IL-6-type cytokine receptor ligand interactions; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-12 signaling; Interleukin-23 signaling; Interleukin-27 signaling; Evasion by RSV of host interferon responses; Other interleukin signaling" "Type III interferon signaling; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; IL6 signaling pathway; IL-4 signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Th17 cell differentiation pathway; IL-26 signaling pathways; Interferon type I signaling pathways" "36" "0" "1.486" "1.312" "1.151" "1.583" "1.311" "1.425" "1.725" "1.624" "2.896" "17.5" "26.1" "23.0" "20.2" "27.8" "23.0" "25.0" "30.3" "28.5" "50.8" "" "" "" "" "" "" "" "" "" "" "15.8" "20.1" "17.8" "13.6" "23.2" "19.6" "21.2" "21.9" "19.2" "50.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4597879666501405539" "False" "High" "IsMasterProtein" "Q9NX08" "COMM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=COMMD8 PE=1 SV=1" "0.008" "False" "2.173" "4" "1" "1" "1" "183" "21.1" "5.43" "2.92" "1" "" "cytosol;nucleus" "" "Pf07258" "54951" "ENSG00000169019" "COMMD8" "hsa:54951; Q8WUR4; Q9HC15; Q9NX08" "Neddylation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "584714024089658403" "False" "High" "IsMasterProtein" "Q5XPI4" "E3 ubiquitin-protein ligase RNF123 OS=Homo sapiens OX=9606 GN=RNF123 PE=1 SV=1" "0.008" "False" "2.170" "1" "1" "1" "1" "1314" "148.4" "6.74" "0.00" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf13920" "63891" "ENSG00000164068" "RNF123" "A1L4Q3; A6NLS5; hsa:63891; Q5I022; Q5XPI4; Q6PFW4; Q71RH0; Q8IW18; Q9H0M8; Q9H5L8; Q9H9T2" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785524813624673912" "False" "High" "IsMasterProtein" "P19086" "Guanine nucleotide-binding protein G(z) subunit alpha OS=Homo sapiens OX=9606 GN=GNAZ PE=1 SV=3" "0.008" "False" "2.164" "2" "1" "1" "1" "355" "40.9" "7.61" "2.67" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2781" "ENSG00000128266" "GNAZ" "B2R6C1; P19086; Q4QRJ6" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production" "Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells" "10" "0" "0.969" "0.814" "1.021" "0.957" "0.739" "0.891" "0.786" "0.902" "0.708" "85.8" "83.1" "69.8" "87.6" "82.1" "63.4" "76.4" "67.4" "77.4" "60.7" "" "" "" "" "" "" "" "" "" "" "77.4" "64.1" "54.0" "59.0" "68.5" "54.1" "64.8" "48.8" "52.2" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6221912277285666984" "False" "High" "IsMasterProtein" "Q5TC12" "ATP synthase mitochondrial F1 complex assembly factor 1 OS=Homo sapiens OX=9606 GN=ATPAF1 PE=1 SV=1" "0.009" "False" "2.161" "2" "1" "1" "1" "328" "36.4" "7.96" "2.49" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf06644" "64756" "ENSG00000123472" "ATPAF1" "B1AQW7; B7Z7D6; B7Z7I6; hsa:64756; Q5TC12; Q9H6E3" "" "7q11.23 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7866416472238112790" "False" "High" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "0.009" "False" "2.155" "11" "1" "3" "1" "63" "6.9" "7.24" "8.88" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Mitochondrial protein import" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "5" "0" "0.856" "0.879" "0.913" "0.843" "0.743" "0.850" "1.018" "0.804" "0.651" "191.6" "163.9" "168.3" "174.9" "161.4" "142.4" "162.8" "195.0" "154.1" "124.7" "" "" "" "" "" "" "" "" "" "" "172.9" "126.4" "130.2" "117.8" "134.6" "121.5" "138.1" "141.1" "103.9" "124.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256301948778102802" "False" "High" "IsMasterProtein" "Q8NCE0" "tRNA-splicing endonuclease subunit Sen2 OS=Homo sapiens OX=9606 GN=TSEN2 PE=1 SV=2" "0.009" "False" "2.151" "2" "1" "1" "1" "465" "53.2" "7.85" "2.51" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01974, Pf02778" "80746" "ENSG00000154743" "TSEN2" "B7Z6K1; C9IZI7; G5E9Q3; hsa:80746; Q8NCE0; Q8WTW7; Q9BPU7" "tRNA processing in the nucleus" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6685402705848511390" "False" "High" "IsMasterProtein" "Q92820" "Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2" "0.009" "False" "2.149" "3" "1" "1" "1" "318" "35.9" "7.11" "2.82" "1" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00117, Pf07722" "8836" "ENSG00000137563" "GGH" "hsa:8836; Q92820" "Neutrophil degranulation" "Fluoropyrimidine activity" "2" "0" "0.955" "1.225" "1.006" "1.176" "1.249" "1.148" "0.986" "1.270" "0.949" "64.0" "61.2" "78.5" "64.4" "75.3" "80.0" "73.5" "63.1" "81.3" "60.8" "" "" "" "" "" "" "" "" "" "" "57.8" "47.2" "60.7" "43.4" "62.8" "68.3" "62.4" "45.7" "54.9" "60.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5593036104782441701" "False" "High" "IsMasterProtein" "Q8NCF5" "NFATC2-interacting protein OS=Homo sapiens OX=9606 GN=NFATC2IP PE=1 SV=1" "0.009" "False" "2.144" "2" "1" "1" "1" "419" "45.8" "6.60" "2.36" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf11976" "84901" "ENSG00000176953" "NFATC2IP" "B7Z4G5; hsa:84901; Q66K34; Q6NVK1; Q8NCF5; Q8NFR2; Q96ST9" "" "16p11.2 distal deletion syndrome" "1" "0" "0.712" "0.821" "0.861" "0.816" "0.715" "0.766" "0.744" "0.538" "1.599" "27.1" "19.3" "22.3" "23.4" "22.1" "19.4" "20.8" "20.2" "14.6" "43.4" "" "" "" "" "" "" "" "" "" "" "24.5" "14.9" "17.2" "15.7" "18.5" "16.5" "17.6" "14.6" "9.8" "43.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1537630137721928118" "False" "High" "IsMasterProtein" "Q8IU60" "m7GpppN-mRNA hydrolase OS=Homo sapiens OX=9606 GN=DCP2 PE=1 SV=3" "0.009" "False" "2.136" "2" "1" "1" "1" "420" "48.4" "8.00" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293, Pf05026" "167227" "ENSG00000172795" "DCP2" "C9J778; hsa:167227; Q6P2D4; Q7Z5W5; Q8IU60; Q8NBG5" "mRNA decay by 5' to 3' exoribonuclease; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "Not Found" "High" "High" "High" "Not Found" "High" "1" "" "3858679499056122524" "False" "High" "IsMasterProtein" "P53370" "Nucleoside diphosphate-linked moiety X motif 6 OS=Homo sapiens OX=9606 GN=NUDT6 PE=1 SV=2" "0.009" "False" "2.135" "3" "1" "1" "1" "316" "35.7" "8.00" "3.67" "1" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293, Pf18290" "11162" "ENSG00000170917" "NUDT6" "A8K756; hsa:11162; O95097; P53370; Q9UQD9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850539477477938049" "False" "High" "IsMasterProtein" "Q9Y2J8" "Protein-arginine deiminase type-2 OS=Homo sapiens OX=9606 GN=PADI2 PE=1 SV=2" "0.009" "False" "2.126" "2" "1" "1" "1" "665" "75.5" "5.59" "2.35" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03068, Pf08526, Pf08527" "11240" "ENSG00000117115; ENSG00000291387" "PADI2" "hsa:11240; Q96DA7; Q9UPN2; Q9Y2J8" "Neutrophil degranulation; Chromatin modifying enzymes" "" "2" "0" "0.876" "1.088" "1.199" "0.997" "0.901" "1.144" "1.026" "1.088" "0.691" "14.2" "12.5" "15.5" "17.0" "14.2" "12.8" "16.3" "14.6" "15.5" "9.8" "" "" "" "" "" "" "" "" "" "" "12.8" "9.6" "12.0" "11.5" "11.8" "10.9" "13.8" "10.6" "10.4" "9.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8871370198028658557" "False" "High" "IsMasterProtein" "P62995" "Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1" "0.009" "False" "2.115" "2" "1" "1" "1" "288" "33.6" "11.25" "2.64" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6434" "ENSG00000136527" "TRA2B" "B4DVK2; D3DNU3; hsa:6434; O15449; P62995; Q15815; Q64283" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "mRNA processing" "5" "0" "1.054" "1.312" "1.089" "1.194" "1.596" "1.234" "0.966" "1.327" "1.536" "87.6" "92.3" "114.9" "95.4" "104.6" "139.8" "108.1" "84.6" "116.2" "134.6" "" "" "" "" "" "" "" "" "" "" "79.1" "71.2" "88.9" "64.2" "87.2" "119.3" "91.7" "61.2" "78.4" "134.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842093119600263742" "False" "High" "IsMasterProtein" "Q15788" "Nuclear receptor coactivator 1 OS=Homo sapiens OX=9606 GN=NCOA1 PE=1 SV=3" "0.009" "False" "2.108" "1" "1" "1" "1" "1441" "156.7" "6.20" "3.06" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16665" "8648" "ENSG00000084676" "NCOA1" "O00150; O43792; O43793; Q13071; Q13420; Q15788; Q2T9G5; Q53SX3; Q6GVI5; Q7KYV3" "SUMOylation of transcription cofactors; Heme signaling; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; HATs acetylate histones; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Recycling of bile acids and salts; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol" "Androgen receptor signaling pathway; Energy metabolism; Leptin signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; IL6 signaling pathway; Breast cancer pathway" "30" "0" "0.926" "1.022" "0.896" "1.111" "1.068" "0.853" "0.884" "0.938" "2.359" "67.8" "62.8" "69.3" "60.8" "75.4" "72.4" "57.9" "60.0" "63.6" "160.0" "" "" "" "" "" "" "" "" "" "" "61.2" "48.5" "53.6" "40.9" "62.9" "61.8" "49.1" "43.4" "42.9" "160.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3376743551660886452" "False" "High" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "0.009" "False" "2.107" "6" "1" "2" "1" "163" "17.6" "10.30" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5117695276373963239" "False" "High" "IsMasterProtein" "Q9UKL0" "REST corepressor 1 OS=Homo sapiens OX=9606 GN=RCOR1 PE=1 SV=2" "0.009" "False" "2.106" "2" "1" "1" "1" "485" "53.3" "7.03" "2.83" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "23186" "ENSG00000089902" "RCOR1" "hsa:23186; J3KN32; Q15044; Q6P2I9; Q86VG5; Q9UKL0" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; Factors involved in megakaryocyte development and platelet production; HDACs deacetylate histones" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1539754074245543228" "False" "High" "IsMasterProtein" "O94986" "Centrosomal protein of 152 kDa OS=Homo sapiens OX=9606 GN=CEP152 PE=1 SV=4" "0.009" "False" "2.106" "0" "1" "1" "1" "1710" "195.5" "5.60" "2.17" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22995" "ENSG00000103995" "CEP152" "E7ER66; hsa:22995; O94986; Q17RV1; Q6NTA0" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6924656061698190740" "False" "High" "IsMasterProtein" "Cont_Q2UVX4" "Complement C3 OS=Bos taurus OX=9913 GN=C3 PE=1 SV=2" "0.009" "True" "2.104" "1" "1" "1" "1" "1661" "187.1" "6.84" "2.77" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00207, Pf01759, Pf01821, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17790, Pf17791, Pf21308, Pf21406" "280677" "ENSBTAG00000017280" "C3" "bta:280677; Q2KIZ4; Q2UVX4" "Neutrophil degranulation; Peptide ligand-binding receptors; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; G alpha (i) signalling events; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5" "Complement and coagulation cascades; Complement activation, classical pathway" "11" "0" "1.027" "1.319" "1.212" "1.108" "1.591" "1.207" "1.023" "1.582" "1.155" "30.0" "30.8" "39.6" "36.4" "33.3" "47.7" "36.2" "30.7" "47.5" "34.7" "" "" "" "" "" "" "" "" "" "" "27.1" "23.8" "30.6" "24.5" "27.7" "40.8" "30.7" "22.2" "32.0" "34.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9052184028571704461" "False" "High" "IsMasterProtein" "O75865" "Trafficking protein particle complex subunit 6A OS=Homo sapiens OX=9606 GN=TRAPPC6A PE=1 SV=2" "0.009" "False" "2.103" "5" "1" "1" "1" "159" "17.6" "5.26" "2.74" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf04051" "79090" "ENSG00000007255" "TRAPPC6A" "hsa:79090; K7ERB1; K7ERQ4; O75865; Q9BQ45; Q9P092" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "" "2" "0" "1.074" "1.225" "1.065" "1.167" "0.886" "1.178" "1.030" "1.067" "1.173" "54.6" "58.7" "66.9" "58.2" "63.7" "48.4" "64.4" "56.3" "58.3" "64.1" "" "" "" "" "" "" "" "" "" "" "49.3" "45.3" "51.8" "39.2" "53.2" "41.3" "54.6" "40.7" "39.3" "64.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3451981213719268513" "False" "High" "IsMasterProtein" "Q9Y5Y6" "Suppressor of tumorigenicity 14 protein OS=Homo sapiens OX=9606 GN=ST14 PE=1 SV=2" "0.009" "False" "2.102" "1" "1" "1" "1" "855" "94.7" "6.55" "3.36" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00057, Pf00089, Pf00431, Pf01390" "6768" "ENSG00000149418" "ST14" "hsa:6768; Q9BS01; Q9H3S0; Q9HB36; Q9HCA3; Q9Y5Y6" "Formation of the cornified envelope" "" "1" "0" "1.036" "1.025" "1.289" "1.156" "0.836" "1.123" "1.173" "1.074" "0.794" "122.8" "127.2" "125.8" "158.2" "141.8" "102.7" "137.9" "144.0" "131.8" "97.5" "" "" "" "" "" "" "" "" "" "" "110.8" "98.1" "97.3" "106.6" "118.3" "87.6" "117.0" "104.2" "88.9" "97.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2452511729080939995" "False" "High" "IsMasterProtein" "O95159" "Zinc finger protein-like 1 OS=Homo sapiens OX=9606 GN=ZFPL1 PE=1 SV=2" "0.009" "False" "2.102" "3" "1" "1" "1" "310" "34.1" "8.07" "2.70" "1" "transport;other biological processes" "other membranes;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "7542" "ENSG00000162300" "ZFPL1" "A8K7E9; hsa:7542; O14616; O95159; Q9UID0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3242855938982215798" "False" "High" "IsMasterProtein" "Q9BQP7" "Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1" "0.009" "False" "2.096" "2" "1" "1" "1" "344" "39.4" "7.68" "2.83" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf12705" "92667" "ENSG00000125871" "MGME1" "B2RDG5; D3DW29; hsa:92667; Q96SW3; Q9BQP7" "" "Primary ovarian insufficiency" "1" "0" "1.049" "0.997" "1.113" "1.095" "0.968" "1.047" "1.028" "1.077" "0.861" "233.8" "245.2" "233.2" "260.1" "255.9" "226.4" "244.7" "240.4" "251.8" "201.3" "" "" "" "" "" "" "" "" "" "" "211.0" "189.2" "180.4" "175.1" "213.5" "193.2" "207.6" "174.0" "169.8" "201.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "103112105648951971" "False" "High" "IsMasterProtein" "Q8NB16" "Mixed lineage kinase domain-like protein OS=Homo sapiens OX=9606 GN=MLKL PE=1 SV=1" "0.010" "False" "2.095" "1" "1" "1" "1" "471" "54.4" "8.82" "2.22" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf07714" "197259" "ENSG00000168404" "MLKL" "A6NCE4; hsa:197259; Q8N6V0; Q8NB16" "Regulation of necroptotic cell death; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis" "DNA damage response (only ATM dependent)" "5" "0" "1.057" "0.877" "1.332" "1.116" "0.980" "0.933" "1.102" "1.195" "1.075" "67.6" "71.5" "59.3" "90.0" "75.4" "66.2" "63.0" "74.5" "80.8" "72.7" "" "" "" "" "" "" "" "" "" "" "61.0" "55.1" "45.8" "60.6" "62.9" "56.5" "53.5" "53.9" "54.5" "72.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5959854138225624200" "False" "High" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "0.010" "False" "2.088" "0" "1" "1" "1" "1792" "201.4" "9.64" "2.89" "1" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "Antigen processing: Ubiquitination & Proteasome degradation; RHOBTB1 GTPase cycle" "" "2" "0" "0.986" "2.597" "1.186" "0.945" "2.147" "0.997" "0.809" "2.801" "1.114" "81.7" "80.5" "212.0" "96.8" "77.2" "175.3" "81.4" "66.1" "228.8" "91.0" "" "" "" "" "" "" "" "" "" "" "73.7" "62.1" "164.0" "65.2" "64.4" "149.6" "69.1" "47.8" "154.3" "91.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6663996802989080831" "False" "High" "IsMasterProtein" "Q15119" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial OS=Homo sapiens OX=9606 GN=PDK2 PE=1 SV=2" "0.010" "False" "2.087" "2" "1" "1" "1" "407" "46.1" "6.61" "1.80" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5164" "ENSG00000005882" "PDK2" "A8K3A7; B3KNW0; hsa:5164; Q15119; Q6P515; Q9BS05" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6011975362988594492" "False" "High" "IsMasterProtein" "Cont_Q3T052" "Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus OX=9913 GN=ITIH4 PE=1 SV=1" "0.010" "True" "2.086" "1" "1" "1" "1" "916" "101.4" "6.68" "2.55" "1" "other metabolic processes;stress response" "non-structural extracellular" "enzyme regulator activity" "Pf00092, Pf06668, Pf08487" "513700" "" "ITIH4" "bta:513700; Q3T052" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5789222212720460962" "False" "High" "IsMasterProtein" "Q9HBE5" "Interleukin-21 receptor OS=Homo sapiens OX=9606 GN=IL21R PE=1 SV=1" "0.010" "False" "2.078" "2" "1" "1" "1" "538" "59.1" "4.70" "2.86" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "" "50615" "ENSG00000103522" "IL21R" "A8K9E8; D3DWF7; hsa:50615; Q96HZ1; Q9HB91; Q9HBE5" "Interleukin-21 signaling" "Regulatory circuits of the STAT3 signaling pathway; Th17 cell differentiation pathway; Inflammatory bowel disease signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1820154667624248039" "False" "High" "IsMasterProtein" "P54098" "DNA polymerase subunit gamma-1 OS=Homo sapiens OX=9606 GN=POLG PE=1 SV=1" "0.010" "False" "2.077" "1" "1" "1" "1" "1239" "139.5" "6.90" "1.98" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf18136" "5428" "ENSG00000140521" "POLG" "hsa:5428; P54098; Q8NFM2; Q92515" "" "Male infertility; Primary ovarian insufficiency" "2" "0" "0.996" "0.964" "1.001" "1.021" "1.061" "0.925" "0.856" "0.983" "2.167" "142.4" "141.9" "137.2" "142.5" "145.4" "151.1" "131.7" "121.8" "140.0" "308.6" "" "" "" "" "" "" "" "" "" "" "128.5" "109.4" "106.1" "96.0" "121.3" "129.0" "111.7" "88.2" "94.4" "308.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6163151869954126091" "False" "High" "IsMasterProtein" "Q9P2S5" "WD repeat-containing protein WRAP73 OS=Homo sapiens OX=9606 GN=WRAP73 PE=1 SV=1" "0.010" "False" "2.070" "2" "1" "1" "1" "460" "51.6" "6.81" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "49856" "ENSG00000116213" "WRAP73" "hsa:49856; Q5T0D6; Q9BUH7; Q9NTK7; Q9NX56; Q9P2S5" "" "" "0" "0" "1.027" "0.981" "0.828" "0.959" "0.842" "0.905" "0.770" "0.874" "0.719" "40.7" "41.8" "39.9" "33.7" "39.0" "34.3" "36.8" "31.3" "35.5" "29.3" "" "" "" "" "" "" "" "" "" "" "36.7" "32.2" "30.9" "22.7" "32.5" "29.3" "31.2" "22.7" "24.0" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2811678325838740313" "False" "High" "IsMasterProtein" "Q9NXW9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1" "0.010" "False" "2.066" "3" "1" "1" "1" "302" "33.8" "6.67" "3.13" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "54784" "ENSG00000160993" "ALKBH4" "hsa:54784; Q53H92; Q9H6A4; Q9NXW9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8867340794532680383" "False" "Medium" "IsMasterProtein" "O94967" "WD repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=WDR47 PE=1 SV=1" "0.010" "False" "2.063" "1" "1" "1" "1" "919" "101.9" "5.94" "2.02" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400, Pf17814" "22911" "ENSG00000085433" "WDR47" "A8MX09; hsa:22911; O94967; Q5TYV7; Q5TYV8; Q5TYV9; Q8IXT7; Q8IYU9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6648624995345891134" "False" "Medium" "IsMasterProtein" "Q96T23" "Remodeling and spacing factor 1 OS=Homo sapiens OX=9606 GN=RSF1 PE=1 SV=2" "0.010" "False" "2.063" "0" "1" "1" "1" "1441" "163.7" "5.01" "2.89" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628, Pf15612" "51773" "ENSG00000048649" "RSF1" "hsa:51773; Q86X86; Q96T23; Q9H3L8; Q9NVZ8; Q9NYU0" "Deposition of new CENPA-containing nucleosomes at the centromere" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8455796813251333225" "False" "Medium" "IsMasterProtein" "Q92750" "Transcription initiation factor TFIID subunit 4B OS=Homo sapiens OX=9606 GN=TAF4B PE=1 SV=2" "0.010" "False" "2.059" "1" "1" "1" "1" "862" "91.0" "9.54" "2.55" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6875" "ENSG00000141384" "TAF4B" "hsa:6875; Q29YA4; Q29YA5; Q92750" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "" "9" "0" "0.748" "0.865" "0.883" "0.862" "1.023" "0.906" "1.038" "0.806" "0.742" "47.8" "35.8" "41.4" "42.2" "41.2" "48.9" "43.3" "49.6" "38.5" "35.5" "" "" "" "" "" "" "" "" "" "" "43.2" "27.6" "32.0" "28.4" "34.4" "41.8" "36.8" "35.9" "26.0" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739657141075103728" "False" "Medium" "IsMasterProtein" "Q9NRN9" "rRNA N6-adenosine-methyltransferase METTL5 OS=Homo sapiens OX=9606 GN=METTL5 PE=1 SV=1" "0.010" "False" "2.058" "4" "1" "3" "1" "209" "23.7" "6.68" "4.47" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29081" "ENSG00000138382" "METTL5" "D3DPC9; hsa:29081; Q9NRN9; Q9NVX1" "" "" "0" "0" "0.954" "1.005" "1.004" "0.907" "0.766" "1.134" "1.048" "1.002" "0.787" "28.9" "27.6" "29.1" "29.0" "26.2" "22.2" "32.8" "30.3" "29.0" "22.7" "" "" "" "" "" "" "" "" "" "" "26.1" "21.3" "22.5" "19.5" "21.9" "18.9" "27.8" "21.9" "19.5" "22.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6599360429670756188" "False" "Medium" "IsMasterProtein" "Q92902" "BLOC-3 complex member HPS1 OS=Homo sapiens OX=9606 GN=HPS1 PE=1 SV=2" "0.010" "False" "2.055" "1" "1" "1" "1" "700" "79.2" "5.91" "3.27" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf19036, Pf19037, Pf19038" "3257" "ENSG00000107521" "HPS1" "A8MRT2; O15402; O15502; Q5TAA3; Q8WXE5; Q92902" "RAB GEFs exchange GTP for GDP on RABs" "IL-18 signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-531095149826683174" "False" "Medium" "IsMasterProtein" "Q86WX3" "Active regulator of SIRT1 OS=Homo sapiens OX=9606 GN=RPS19BP1 PE=1 SV=1" "0.010" "False" "2.054" "5" "1" "1" "1" "136" "15.4" "10.74" "2.12" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15684" "91582" "ENSG00000187051" "RPS19BP1" "B0QY96; hsa:91582; Q5JZA1; Q86WX3" "Regulation of HSF1-mediated heat shock response" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5570985190498897976" "False" "Medium" "IsMasterProtein" "P28676" "Grancalcin OS=Homo sapiens OX=9606 GN=GCA PE=1 SV=2" "0.010" "False" "2.053" "3" "1" "1" "1" "217" "24.0" "5.21" "2.32" "1" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202" "25801" "ENSG00000115271" "GCA" "B2R5X3; hsa:25801; P28676; Q53TB5; Q59EP3" "Neutrophil degranulation" "" "1" "0" "1.094" "0.998" "0.951" "0.802" "1.279" "0.901" "0.882" "1.130" "1.111" "34.7" "37.9" "34.6" "33.0" "27.8" "44.3" "31.2" "30.6" "39.2" "38.5" "" "" "" "" "" "" "" "" "" "" "31.3" "29.2" "26.8" "22.2" "23.2" "37.8" "26.5" "22.1" "26.4" "38.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "947873724462567429" "False" "Medium" "IsMasterProtein" "Q9UNQ2" "Dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1" "0.010" "False" "2.052" "3" "1" "1" "1" "313" "35.2" "9.99" "3.08" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00398" "27292" "ENSG00000086189" "DIMT1" "O76025; Q9BU77; Q9UES1; Q9UNQ2" "rRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7298475413649471285" "False" "Medium" "IsMasterProtein" "Q9NPG4" "Protocadherin-12 OS=Homo sapiens OX=9606 GN=PCDH12 PE=1 SV=1" "0.010" "False" "2.045" "2" "1" "1" "1" "1184" "128.9" "5.29" "2.21" "1" "cell adhesion;other metabolic processes;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00028, Pf08266" "51294" "ENSG00000113555" "PCDH12" "hsa:51294; Q6UXB6; Q96KB8; Q9H7Y6; Q9H8E0; Q9NPG4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2644612551078172980" "False" "Medium" "IsMasterProtein" "Q9NYQ3" "2-Hydroxyacid oxidase 2 OS=Homo sapiens OX=9606 GN=HAO2 PE=1 SV=1" "0.010" "False" "2.044" "2" "1" "4" "1" "351" "38.8" "7.64" "6.33" "1" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01070" "51179" "ENSG00000116882" "HAO2" "hsa:51179; Q2TU86; Q5QP00; Q9NYQ3; Q9UJS6" "Peroxisomal lipid metabolism; Peroxisomal protein import" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5539226776075582677" "False" "Medium" "IsMasterProtein" "Q5TC82" "Roquin-1 OS=Homo sapiens OX=9606 GN=RC3H1 PE=1 SV=1" "0.010" "False" "2.043" "1" "1" "1" "1" "1133" "125.7" "7.27" "2.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf14634, Pf18386, Pf21206" "149041" "ENSG00000135870" "RC3H1" "B3KVK1; hsa:149041; Q5TC82; Q5W180; Q5W181; Q8IVE6; Q8N9V1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1292677114640833852" "False" "Medium" "IsMasterProtein" "Q5VZL5" "Zinc finger MYM-type protein 4 OS=Homo sapiens OX=9606 GN=ZMYM4 PE=1 SV=1" "0.010" "False" "2.037" "0" "1" "1" "1" "1548" "172.7" "6.84" "2.79" "1" "cell organization and biogenesis;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9202" "ENSG00000146463" "ZMYM4" "A0JP19; A0JP20; hsa:9202; O43308; Q5T5E1; Q5T5E2; Q5VZL5; Q7L3Q4" "" "" "0" "0" "0.948" "1.138" "1.242" "0.970" "0.849" "1.020" "1.021" "1.103" "1.462" "50.1" "47.5" "57.0" "62.2" "48.6" "42.5" "51.1" "51.2" "55.2" "73.3" "" "" "" "" "" "" "" "" "" "" "45.2" "36.6" "44.1" "41.9" "40.5" "36.3" "43.4" "37.0" "37.3" "73.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "795128292940512142" "False" "Medium" "IsMasterProtein" "Q96IU2" "Zinc finger BED domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZBED3 PE=1 SV=1" "0.010" "False" "2.029" "4" "1" "1" "1" "234" "25.1" "8.31" "2.62" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892" "84327" "ENSG00000132846" "ZBED3" "hsa:84327; Q96IU2" "" "" "0" "0" "1.036" "0.921" "1.173" "1.047" "0.964" "1.069" "1.130" "1.094" "0.922" "96.6" "100.0" "89.0" "113.3" "101.1" "93.1" "103.3" "109.2" "105.7" "89.0" "" "" "" "" "" "" "" "" "" "" "87.2" "77.2" "68.8" "76.3" "84.4" "79.5" "87.6" "79.0" "71.3" "89.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-383335111069342987" "False" "Medium" "IsMasterProtein" "Q6PD74" "Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1" "0.010" "False" "2.024" "3" "1" "1" "1" "315" "34.6" "4.64" "2.89" "1" "transport" "cytosol;nucleus;other cell component" "" "Pf10199" "79719" "ENSG00000103591" "AAGAB" "B4DG44; hsa:79719; Q6FI86; Q6PD74; Q7Z5X9; Q9H0P1; Q9HAK0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3888271252204207662" "False" "Medium" "IsMasterProtein" "Q9UM73" "ALK tyrosine kinase receptor OS=Homo sapiens OX=9606 GN=ALK PE=1 SV=3" "0.010" "False" "2.019" "1" "1" "1" "1" "1620" "176.3" "7.08" "2.69" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00629, Pf07714, Pf12810" "238" "ENSG00000171094" "ALK" "A6P4T4; A6P4V4; hsa:238; Q4ZFX9; Q53QQ6; Q53RZ4; Q59FI3; Q9UM73; Q9Y4K6" "Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; Signaling by ALK; MDK and PTN in ALK signaling; ASP-3026-resistant ALK mutants; NVP-TAE684-resistant ALK mutants; alectinib-resistant ALK mutants; brigatinib-resistant ALK mutants; ceritinib-resistant ALK mutants; crizotinib-resistant ALK mutants; lorlatinib-resistant ALK mutants" "Pluripotent stem cell differentiation pathway; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer" "14" "0" "1.030" "1.121" "0.953" "0.841" "0.936" "0.810" "0.870" "1.163" "0.781" "70.1" "72.3" "78.6" "66.9" "59.0" "65.7" "56.8" "61.0" "81.5" "54.7" "" "" "" "" "" "" "" "" "" "" "63.3" "55.7" "60.8" "45.0" "49.2" "56.0" "48.2" "44.2" "55.0" "54.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7789640174005982269" "False" "Medium" "IsMasterProtein" "Q9Y5R2" "Matrix metalloproteinase-24 OS=Homo sapiens OX=9606 GN=MMP24 PE=1 SV=1" "0.011" "False" "2.009" "2" "1" "1" "1" "645" "73.2" "9.23" "1.88" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00045, Pf00413, Pf01471, Pf11857" "10893" "ENSG00000125966" "MMP24" "B7ZBG8; hsa:10893; Q9H440; Q9Y5R2" "Activation of Matrix Metalloproteinases" "Matrix metalloproteinases; Chronic hyperglycemia impairment of neuron function" "3" "0" "0.721" "0.948" "1.346" "1.104" "0.807" "0.770" "0.952" "1.202" "0.685" "17.7" "12.8" "16.8" "23.9" "19.6" "14.3" "13.7" "16.9" "21.3" "12.1" "" "" "" "" "" "" "" "" "" "" "16.0" "9.9" "13.0" "16.1" "16.3" "12.2" "11.6" "12.2" "14.4" "12.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2858962051142088186" "False" "Medium" "IsMasterProtein" "Q8WXE1" "ATR-interacting protein OS=Homo sapiens OX=9606 GN=ATRIP PE=1 SV=1" "0.011" "False" "2.008" "1" "1" "1" "1" "791" "85.8" "6.32" "2.00" "1" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "" "84126" "ENSG00000164053" "ATRIP" "A8K6A3; A8K714; B2RCE7; B4DU92; B5MEB7; hsa:84126; Q69YK9; Q8NHQ2; Q8WUG7; Q8WXE1; Q96CL3; Q9HA30" "Fanconi Anemia Pathway; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "11" "0" "0.795" "0.713" "0.909" "0.846" "0.856" "0.957" "0.865" "0.834" "0.700" "59.2" "47.1" "42.2" "53.8" "50.1" "50.7" "56.7" "51.2" "49.4" "41.4" "" "" "" "" "" "" "" "" "" "" "53.4" "36.3" "32.7" "36.2" "41.8" "43.2" "48.1" "37.1" "33.3" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "948534183126948466" "False" "Medium" "IsMasterProtein" "Q8IWE5" "Pleckstrin homology domain-containing family M member 2 OS=Homo sapiens OX=9606 GN=PLEKHM2 PE=1 SV=2" "0.011" "False" "2.008" "1" "1" "1" "1" "1019" "112.7" "4.93" "3.08" "1" "cell organization and biogenesis;stress response;other biological processes" "other membranes;other cytoplasmic organelle" "cytoskeletal activity" "Pf00169, Pf02759" "23207" "ENSG00000116786" "PLEKHM2" "O94928; Q5VT65; Q5VVD7; Q6NUH9; Q7L8G1; Q8IVT7; Q8IWE5; Q8N2T4; Q96AY0; Q9NTF7" "" "" "0" "0" "1.087" "0.948" "0.894" "1.045" "0.977" "1.040" "1.096" "0.965" "1.050" "134.1" "145.7" "127.1" "119.8" "140.1" "131.0" "139.4" "146.9" "129.4" "140.7" "" "" "" "" "" "" "" "" "" "" "121.0" "112.4" "98.3" "80.7" "116.9" "111.8" "118.3" "106.3" "87.3" "140.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7093450291997999147" "False" "Medium" "IsMasterProtein" "Q7Z5G4" "Golgin subfamily A member 7 OS=Homo sapiens OX=9606 GN=GOLGA7 PE=1 SV=2" "0.011" "False" "2.006" "6" "1" "1" "1" "137" "15.8" "7.05" "2.97" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "" "Pf10256" "51125" "ENSG00000147533" "GOLGA7" "D3DSX9; hsa:51125; J3KQ24; Q7Z5G4; Q96EQ4; Q9P1S0; Q9Y5U7" "Neutrophil degranulation; RAS processing; Maturation of spike protein" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986352754293277242" "False" "Medium" "IsMasterProtein" "P61513" "Large ribosomal subunit protein eL43 OS=Homo sapiens OX=9606 GN=RPL37A PE=1 SV=2" "0.011" "False" "2.004" "9" "1" "1" "1" "92" "10.3" "10.43" "2.79" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01780" "6168" "ENSG00000197756" "RPL37A" "hsa:6168; P12751; P61513; Q6FGF5" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Selenocysteine synthesis; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "0.833" "1.212" "1.157" "1.052" "1.028" "1.223" "0.937" "1.060" "0.428" "156.1" "130.1" "189.2" "180.6" "164.3" "160.5" "190.8" "146.2" "165.5" "66.8" "" "" "" "" "" "" "" "" "" "" "140.9" "100.3" "146.4" "121.6" "137.0" "137.0" "161.9" "105.8" "111.6" "66.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2603490362497748862" "False" "Medium" "IsMasterProtein" "P49961" "Ectonucleoside triphosphate diphosphohydrolase 1 OS=Homo sapiens OX=9606 GN=ENTPD1 PE=1 SV=1" "0.011" "False" "2.003" "1" "1" "1" "1" "510" "57.9" "6.34" "2.80" "1" "cell adhesion;other metabolic processes;stress response" "plasma membrane;other membranes" "other molecular function" "Pf01150" "953" "ENSG00000138185" "ENTPD1" "A9Z1X8; B4DWB9; B4E1X1; B7Z599; G3XAF6; hsa:953; P49961; Q5T561; Q5T562; Q86VV3; Q9UQQ9; Q9Y3Q9" "Purinergic signaling in leishmaniasis infection; Phosphate bond hydrolysis by NTPDase proteins" "Pyrimidine metabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864595288643475005" "False" "Medium" "IsMasterProtein" "P61011" "Signal recognition particle subunit SRP54 OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1" "0.011" "False" "2.000" "2" "1" "1" "1" "504" "55.7" "8.75" "1.67" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00448, Pf02881, Pf02978" "6729" "ENSG00000100883" "SRP54" "B2R759; B4DUW6; hsa:6729; P13624; P61011" "SRP-dependent cotranslational protein targeting to membrane" "VEGFA-VEGFR2 signaling; mRNA processing" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4489642059379383551" "False" "Medium" "IsMasterProtein" "Q6PD62" "RNA polymerase-associated protein CTR9 homolog OS=Homo sapiens OX=9606 GN=CTR9 PE=1 SV=1" "0.011" "False" "2.000" "1" "1" "1" "1" "1173" "133.4" "6.77" "2.41" "1" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13181, Pf13374" "9646" "ENSG00000198730" "CTR9" "D3DQV8; hsa:9646; Q15015; Q6PD62" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "Endoderm differentiation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750059555873910244" "False" "Medium" "IsMasterProtein" "Q96KB5" "Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3" "0.011" "False" "1.997" "2" "1" "1" "1" "322" "36.1" "5.12" "2.78" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "55872" "ENSG00000168078" "PBK" "B4DX68; D3DST2; hsa:55872; Q96KB5; Q9NPD9; Q9NYL7; Q9NZK6" "" "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling" "2" "0" "1.034" "1.225" "1.032" "1.095" "0.940" "1.047" "0.527" "0.972" "8.726" "62.2" "64.3" "76.1" "64.1" "68.1" "58.4" "65.1" "32.8" "60.4" "542.4" "" "" "" "" "" "" "" "" "" "" "56.1" "49.6" "58.9" "43.2" "56.8" "49.9" "55.2" "23.7" "40.7" "542.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6159664741780628895" "False" "Medium" "IsMasterProtein" "Q9P2K3" "REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2" "0.011" "False" "1.997" "2" "1" "1" "1" "495" "55.5" "8.27" "2.57" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "55758" "ENSG00000117625" "RCOR3" "B3KYA2; B4DYY7; hsa:55758; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83; Q9P2K3" "" "" "0" "0" "1.053" "1.285" "0.748" "1.039" "1.135" "1.099" "1.258" "0.958" "2.027" "25.3" "26.6" "32.5" "18.9" "26.3" "28.7" "27.8" "31.8" "24.2" "51.3" "" "" "" "" "" "" "" "" "" "" "22.8" "20.6" "25.1" "12.7" "21.9" "24.5" "23.6" "23.0" "16.3" "51.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262786275028472849" "False" "Medium" "IsMasterProtein" "Q9Y421" "Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2" "0.011" "False" "1.994" "8" "1" "1" "1" "112" "13.2" "9.99" "0.00" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf08555" "26017" "ENSG00000105058" "FAM32A" "hsa:26017; Q9BT02; Q9Y421" "mRNA Splicing - Major Pathway" "" "1" "0" "0.984" "0.887" "0.871" "0.891" "1.039" "0.865" "0.986" "0.952" "0.569" "108.1" "106.4" "95.9" "94.2" "96.3" "112.3" "93.5" "106.5" "102.9" "61.5" "" "" "" "" "" "" "" "" "" "" "97.6" "82.1" "74.2" "63.4" "80.3" "95.9" "79.3" "77.1" "69.4" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3452513591771994158" "False" "Medium" "IsMasterProtein" "Q6ICG6" "Uncharacterized protein KIAA0930 OS=Homo sapiens OX=9606 GN=KIAA0930 PE=1 SV=1" "0.011" "False" "1.994" "2" "1" "1" "1" "404" "45.8" "7.94" "1.78" "1" "" "" "" "Pf09741" "23313" "ENSG00000100364" "KIAA0930" "B0QY17; B0QY19; B3KT48; hsa:23313; Q6ICG6; Q6ZVE5; Q7Z6K9; Q8IZ76; Q9Y2E2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2269954353219987429" "False" "Medium" "IsMasterProtein" "O43927" "C-X-C motif chemokine 13 OS=Homo sapiens OX=9606 GN=CXCL13 PE=1 SV=1" "0.011" "False" "1.993" "13" "1" "1" "1" "109" "12.7" "10.33" "1.67" "1" "cell-cell signaling;stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00048" "10563" "ENSG00000156234" "CXCL13" "hsa:10563; O43927" "G alpha (i) signalling events; Chemokine receptors bind chemokines" "Allograft rejection; Chemokine signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Overview of proinflammatory and profibrotic mediators; 2q13 copy number variation syndrome" "7" "0" "1.119" "1.131" "0.969" "1.034" "1.103" "0.787" "1.117" "0.990" "0.637" "19.2" "21.5" "21.7" "18.6" "19.8" "21.2" "15.1" "21.4" "19.0" "12.2" "" "" "" "" "" "" "" "" "" "" "17.3" "16.6" "16.8" "12.5" "16.6" "18.1" "12.8" "15.5" "12.8" "12.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8330278091767700695" "False" "Medium" "IsMasterProtein" "Q6PCB5" "Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2" "0.011" "False" "1.990" "1" "1" "1" "1" "846" "94.8" "8.78" "3.02" "1" "" "nucleus" "other molecular function" "" "222194" "ENSG00000187257" "RSBN1L" "C9K0P1; hsa:222194; Q6PCB5; Q6ZS58; Q6ZVI9; Q86X48" "" "" "0" "0" "0.998" "0.975" "0.907" "1.070" "0.951" "0.986" "1.047" "1.011" "0.819" "79.7" "79.5" "77.6" "72.3" "85.2" "75.8" "78.5" "83.4" "80.5" "65.2" "" "" "" "" "" "" "" "" "" "" "71.9" "61.3" "60.1" "48.7" "71.1" "64.7" "66.6" "60.4" "54.3" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9115866675213369101" "False" "Medium" "IsMasterProtein" "Q99807" "5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ7 PE=1 SV=3" "0.011" "False" "1.990" "5" "1" "1" "1" "217" "24.3" "8.59" "2.19" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf03232" "10229" "ENSG00000167186" "COQ7" "B2RDA9; hsa:10229; Q99807; Q9BTT7; Q9H0T5; Q9UEW5; Q9UNR5" "Ubiquinol biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8066723703653811047" "False" "Medium" "IsMasterProtein" "P53814" "Smoothelin OS=Homo sapiens OX=9606 GN=SMTN PE=1 SV=7" "0.011" "False" "1.989" "1" "1" "1" "1" "917" "99.0" "9.07" "2.76" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf12510" "6525" "ENSG00000183963" "SMTN" "hsa:6525; O00569; O95769; O95937; P53814; Q8N4H8; Q8WWW1; Q8WWW2; Q9P1S8; Q9UIT1; Q9UIT2" "" "" "0" "0" "1.304" "1.363" "1.118" "1.263" "1.124" "1.292" "1.289" "1.217" "2.195" "54.4" "70.9" "74.1" "60.8" "68.7" "61.1" "70.3" "70.1" "66.2" "119.4" "" "" "" "" "" "" "" "" "" "" "49.1" "54.7" "57.3" "41.0" "57.3" "52.2" "59.6" "50.7" "44.6" "119.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6627286514823912553" "False" "Medium" "IsMasterProtein" "Q8TEA1" "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 OS=Homo sapiens OX=9606 GN=NSUN6 PE=1 SV=1" "0.011" "False" "1.989" "2" "1" "1" "1" "469" "51.7" "7.96" "1.91" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "221078" "ENSG00000241058" "NSUN6" "B0YJ54; hsa:221078; Q8TEA1" "tRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9211390500631637896" "False" "Medium" "IsMasterProtein" "P04156" "Major prion protein OS=Homo sapiens OX=9606 GN=PRNP PE=1 SV=1" "0.011" "False" "1.987" "4" "1" "1" "1" "253" "27.6" "9.00" "3.39" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00377, Pf11587" "5621" "ENSG00000171867" "PRNP" "O60489; P04156; P78446; Q15216; Q15221; Q27H91; Q5QPB4; Q8TBG0; Q96E70; Q9UP19" "NCAM1 interactions; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "Complement system; Copper homeostasis; Prion disease pathway; Ferroptosis" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7763347901800507563" "False" "Medium" "IsMasterProtein" "Q9HB19" "Pleckstrin homology domain-containing family A member 2 OS=Homo sapiens OX=9606 GN=PLEKHA2 PE=1 SV=3" "0.011" "False" "1.985" "3" "1" "1" "1" "425" "47.2" "8.66" "2.12" "1" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00169" "59339" "ENSG00000169499" "PLEKHA2" "A8K727; hsa:59339; Q9HB19" "Synthesis of PIPs at the plasma membrane" "" "1" "0" "0.687" "1.099" "1.008" "1.073" "0.941" "1.104" "1.755" "1.020" "3.332" "36.5" "25.1" "40.1" "36.8" "39.1" "34.3" "40.3" "64.0" "37.2" "121.5" "" "" "" "" "" "" "" "" "" "" "32.9" "19.3" "31.0" "24.8" "32.6" "29.3" "34.2" "46.3" "25.1" "121.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749299575230837699" "False" "Medium" "IsMasterProtein" "Q9HAT2" "Sialate O-acetylesterase OS=Homo sapiens OX=9606 GN=SIAE PE=1 SV=1" "0.011" "False" "1.983" "2" "1" "1" "1" "523" "58.3" "7.33" "2.55" "1" "other metabolic processes;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf03629" "54414" "ENSG00000110013" "SIAE" "B3KPB0; hsa:54414; Q8IUT9; Q9HAT2; Q9HAU7; Q9NT71" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1540404723274759842" "False" "Medium" "IsMasterProtein" "P52333" "Tyrosine-protein kinase JAK3 OS=Homo sapiens OX=9606 GN=JAK3 PE=1 SV=2" "0.011" "False" "1.980" "1" "1" "1" "1" "1124" "125.0" "7.18" "1.91" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714, Pf17887, Pf18377, Pf18379" "3718" "ENSG00000105639" "JAK3" "hsa:3718; P52333; Q13259; Q13260; Q13611; Q8N1E8; Q99699; Q9Y6S2" "Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-7 signaling; Signaling by ALK; Interleukin-4 and Interleukin-13 signaling; Interleukin-20 family signaling; Interleukin-2 signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "IL-7 signaling pathway; IL-9 signaling pathway; Oncostatin M signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway" "24" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2663740038882364516" "False" "Medium" "IsMasterProtein" "Q96S82" "Ubiquitin-like protein 7 OS=Homo sapiens OX=9606 GN=UBL7 PE=1 SV=2" "0.011" "False" "1.978" "3" "1" "1" "1" "380" "40.5" "5.07" "2.17" "1" "protein metabolism;other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00240" "84993" "ENSG00000138629; ENSG00000288408" "UBL7" "D3DW57; hsa:84993; Q96I03; Q96S82" "" "" "0" "0" "1.015" "0.855" "1.186" "0.967" "1.158" "1.007" "0.915" "0.788" "0.896" "61.8" "62.8" "52.8" "73.3" "59.8" "71.6" "62.3" "56.6" "48.7" "55.4" "" "" "" "" "" "" "" "" "" "" "55.8" "48.4" "40.9" "49.4" "49.9" "61.1" "52.8" "40.9" "32.9" "55.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676225974724489617" "False" "Medium" "IsMasterProtein" "P02458" "Collagen alpha-1(II) chain OS=Homo sapiens OX=9606 GN=COL2A1 PE=1 SV=3" "0.011" "False" "1.977" "1" "1" "1" "1" "1487" "141.7" "6.92" "2.54" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00093, Pf01391, Pf01410" "1280" "ENSG00000139219" "COL2A1" "A6NGA0; hsa:1280; P02458; Q12985; Q14009; Q14044; Q14045; Q14046; Q14047; Q14056; Q14058; Q16672; Q1JQ82; Q2V4X7; Q6LBY1; Q6LBY2; Q6LBY3; Q96IT5; Q99227; Q9UE38; Q9UE39; Q9UE40; Q9UE41; Q9UE42; Q9UE43" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling" "Neural crest differentiation; Spinal cord injury; Focal adhesion; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Urotensin-II-mediated signaling pathway; 2q11.2 copy number variation syndrome; Osteoarthritic chondrocyte hypertrophy" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5856391887248193599" "False" "Medium" "IsMasterProtein" "Q9H4H8" "Protein FAM83D OS=Homo sapiens OX=9606 GN=FAM83D PE=1 SV=3" "0.011" "False" "1.974" "1" "1" "1" "1" "585" "64.4" "6.54" "2.11" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07894" "81610" "ENSG00000101447" "FAM83D" "B4E1I7; hsa:81610; Q5THR2; Q68EN1; Q6P457; Q7Z6H0; Q96DF5; Q96N89; Q9BVM8; Q9H4H8" "Signaling by EGFR" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3055099900900343627" "False" "Medium" "IsMasterProtein" "Q9P0M9" "Large ribosomal subunit protein bL27m OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1" "0.012" "False" "1.972" "7" "1" "1" "1" "148" "16.1" "10.42" "0.00" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01016" "51264" "ENSG00000108826" "MRPL27" "B2RE14; hsa:51264; Q9P0M9" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6831775040715791940" "False" "Medium" "IsMasterProtein" "Q15043" "Metal cation symporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3" "0.012" "False" "1.970" "3" "1" "1" "1" "492" "54.2" "5.33" "2.17" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "transporter activity" "Pf02535" "23516" "ENSG00000104635" "SLC39A14" "A6NH98; B4DIW3; B6EU88; D3DSR4; hsa:23516; Q15043; Q6ZME8; Q96BB3" "Zinc influx into cells by the SLC39 gene family" "Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis" "5" "0" "1.162" "0.980" "1.026" "1.150" "1.396" "1.327" "1.300" "1.101" "1.009" "21.9" "25.4" "21.5" "22.5" "25.2" "30.5" "29.0" "28.5" "24.1" "22.1" "" "" "" "" "" "" "" "" "" "" "19.8" "19.6" "16.6" "15.1" "21.0" "26.1" "24.6" "20.6" "16.2" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1908933075179858623" "False" "Medium" "IsMasterProtein" "Cont_A2I7N3" "Serpin A3-7 OS=Bos taurus OX=9913 GN=SERPINA3-7 PE=3 SV=1" "0.012" "True" "1.966" "2" "1" "1" "1" "417" "46.9" "6.34" "2.77" "1" "" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "" "" "SERPINA3-7" "A2I7N3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611257715597886633" "False" "Medium" "IsMasterProtein" "Q15555" "Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1" "0.012" "False" "1.960" "2" "1" "2" "1" "327" "37.0" "5.57" "4.19" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "10982" "ENSG00000166974" "MAPRE2" "B2RE21; B3KR39; B4DJV4; B7Z2L3; E9PHR3; F5H1V8; G5E9I6; hsa:10982; Q15555; Q9UQ33" "" "Ciliary landscape" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3706953300411127023" "False" "Medium" "IsMasterProtein" "Cont_Q1RMN8" "Immunoglobulin light chain, lambda gene cluster OS=Bos taurus OX=9913 GN=IGL PE=2 SV=1" "0.013" "True" "1.958" "3" "1" "1" "1" "234" "24.5" "7.62" "2.43" "1" "" "" "" "Pf07654, Pf07686" "" "" "IGL@" "Q1RMN8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4139945587606400296" "False" "Medium" "IsMasterProtein" "Q07352" "mRNA decay activator protein ZFP36L1 OS=Homo sapiens OX=9606 GN=ZFP36L1 PE=1 SV=1" "0.013" "False" "1.949" "2" "1" "1" "1" "338" "36.3" "7.96" "2.92" "1" "cell adhesion;cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "677" "ENSG00000185650" "ZFP36L1" "hsa:677; Q07352; Q13851" "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "Modulators of TCR signaling and T cell activation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4465081379876381336" "False" "Medium" "IsMasterProtein" "Q86U70" "LIM domain-binding protein 1 OS=Homo sapiens OX=9606 GN=LDB1 PE=1 SV=2" "0.013" "False" "1.947" "2" "1" "1" "1" "411" "46.5" "6.96" "2.91" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01803, Pf17916" "8861" "ENSG00000198728" "LDB1" "B4DUC4; hsa:8861; O75479; O96010; Q1EQX1; Q86U70; Q9UGM4" "Regulation of expression of SLITs and ROBOs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Expression and translocation of olfactory receptors; Cardiogenesis" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4497117085705849008" "False" "Medium" "IsMasterProtein" "Q9UHY1" "Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1" "0.013" "False" "1.943" "2" "1" "1" "1" "535" "59.8" "5.08" "3.09" "1" "transport" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "29959" "ENSG00000115216" "NRBP1" "B3KV40; D6W558; hsa:29959; Q53FZ5; Q96SU3; Q9UHY1" "Nuclear Receptor transcription pathway" "" "1" "0" "1.023" "0.998" "1.025" "0.938" "1.227" "0.933" "0.950" "0.910" "1.174" "54.3" "55.5" "54.2" "55.6" "50.9" "66.6" "50.6" "51.5" "49.4" "63.7" "" "" "" "" "" "" "" "" "" "" "49.0" "42.8" "41.9" "37.4" "42.5" "56.8" "42.9" "37.3" "33.3" "63.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6640745081908687038" "False" "Medium" "IsMasterProtein" "O75521" "Enoyl-CoA delta isomerase 2 OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" "0.013" "False" "1.943" "2" "1" "1" "1" "394" "43.6" "9.00" "2.75" "1" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00378, Pf00887" "10455" "ENSG00000198721" "ECI2" "hsa:10455; O75521; Q5JYK5; Q5JYK7; Q7L124; Q8N0X0; Q9BUE9; Q9H0T9; Q9NQH1; Q9NYH7; Q9UN55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634853001095686771" "False" "Medium" "IsMasterProtein" "Q9UBM7" "7-dehydrocholesterol reductase OS=Homo sapiens OX=9606 GN=DHCR7 PE=1 SV=1" "0.013" "False" "1.943" "2" "1" "1" "1" "475" "54.5" "8.70" "2.47" "1" "other metabolic processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf01222" "1717" "ENSG00000172893" "DHCR7" "B2R6Z2; hsa:1717; O60492; O60717; Q9UBM7" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis via desmosterol; Cholesterol biosynthesis via lathosterol" "Vitamin D metabolism; Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "10" "0" "0.976" "1.162" "1.021" "1.073" "1.002" "0.857" "1.136" "1.158" "0.964" "106.7" "104.1" "124.0" "108.9" "114.4" "106.9" "91.4" "121.2" "123.5" "102.8" "" "" "" "" "" "" "" "" "" "" "96.3" "80.3" "95.9" "73.4" "95.4" "91.2" "77.5" "87.7" "83.3" "102.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2919064090187144388" "False" "Medium" "IsMasterProtein" "Cont_P00760" "Serine protease 1 OS=Bos taurus OX=9913 GN=PRSS1 PE=1 SV=3" "0.014" "True" "1.935" "3" "1" "1" "1" "246" "25.8" "8.07" "2.20" "1" "protein metabolism;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf00089" "615026; 780933" "ENSBIXG00000023431; ENSBIXG00005009443; ENSBTAG00000050323; ENSBTAG00000052726" "LOC113890875; PRSS1" "A0A4W2FD21; A6H6Y3; bta:615026; bta:780933; P00760" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243510255652215024" "False" "Medium" "IsMasterProtein" "Q9Y448" "Small kinetochore-associated protein OS=Homo sapiens OX=9606 GN=KNSTRN PE=1 SV=2" "0.014" "False" "1.934" "4" "1" "1" "1" "316" "35.4" "6.30" "1.68" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "90417" "ENSG00000128944" "KNSTRN" "B4DXA7; hsa:90417; Q147U5; Q32Q57; Q5ISJ0; Q6P2S5; Q6PJM0; Q86XB4; Q9Y448" "" "Leukocyte-intrinsic Hippo pathway functions" "1" "0" "0.940" "0.911" "1.612" "1.175" "1.116" "1.093" "1.195" "1.276" "2.518" "17.4" "16.3" "15.8" "28.0" "20.4" "19.4" "19.0" "20.8" "22.2" "43.7" "" "" "" "" "" "" "" "" "" "" "15.7" "12.6" "12.2" "18.8" "17.0" "16.5" "16.1" "15.0" "14.9" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4068487784358334043" "False" "Medium" "IsMasterProtein" "Q8TDX7" "Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1" "0.014" "False" "1.934" "3" "1" "1" "1" "302" "34.5" "8.25" "2.12" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "140609" "ENSG00000151414" "NEK7" "A6NGT8; hsa:140609; Q8TDX7" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "Ciliary landscape; EPAC1 and PKA reduction of retinal inflammation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005223025872710581" "False" "Medium" "IsMasterProtein" "O60524" "Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "0.014" "False" "1.934" "1" "1" "1" "1" "1076" "122.9" "6.35" "2.26" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629072451512354259" "False" "Medium" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0.014" "False" "1.933" "1" "1" "1" "1" "1360" "152.7" "6.90" "2.85" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "763377976952146126" "False" "Medium" "IsMasterProtein" "Q6PF04" "Zinc finger protein 613 OS=Homo sapiens OX=9606 GN=ZNF613 PE=1 SV=2" "0.014" "False" "1.929" "1" "1" "1" "1" "617" "70.1" "8.92" "3.07" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "79898" "ENSG00000176024" "ZNF613" "hsa:79898; Q6PF04; Q96SS9" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3683679323439236664" "False" "Medium" "IsMasterProtein" "Q6IPR3" "tRNA wybutosine-synthesizing protein 3 homolog OS=Homo sapiens OX=9606 GN=TYW3 PE=1 SV=2" "0.015" "False" "1.927" "5" "1" "1" "1" "259" "29.8" "7.68" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02676" "127253" "ENSG00000162623" "TYW3" "B4DSP9; E9PGR7; hsa:127253; Q5HYJ0; Q6IPR3; Q8N7L1" "Synthesis of wybutosine at G37 of tRNA(Phe)" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2474482111697956733" "False" "Medium" "IsMasterProtein" "Q8N4M1" "Choline transporter-like protein 3 OS=Homo sapiens OX=9606 GN=SLC44A3 PE=1 SV=4" "0.015" "False" "1.925" "1" "1" "1" "1" "653" "73.7" "7.69" "2.22" "1" "other metabolic processes;transport" "plasma membrane;other membranes" "transporter activity" "Pf04515" "126969" "ENSG00000143036" "SLC44A3" "B4DVY4; B4E1M4; B7ZA08; E9PJH2; E9PJY8; hsa:126969; Q6UWT1; Q7Z6C5; Q8N4M1; Q9BWY7" "Synthesis of PC; Transport of bile salts and organic acids, metal ions and amine compounds" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224423870794083930" "False" "Medium" "IsMasterProtein" "P49356" "Protein farnesyltransferase subunit beta OS=Homo sapiens OX=9606 GN=FNTB PE=1 SV=1" "0.015" "False" "1.922" "2" "1" "1" "1" "437" "48.7" "5.82" "2.35" "1" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00432" "100529261; 2342" "ENSG00000257365" "FNTB" "B2RDX6; B4E1A0; hsa:100529261; hsa:2342; P49356" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7548754380540719877" "False" "Medium" "IsMasterProtein" "Q96ET8" "Golgi apparatus membrane protein TVP23 homolog C OS=Homo sapiens OX=9606 GN=TVP23C PE=1 SV=3" "0.015" "False" "1.909" "3" "1" "1" "1" "276" "31.1" "9.29" "2.64" "1" "transport" "other membranes" "" "Pf05832" "100533496; 201158" "ENSG00000175106" "TVP23C" "hsa:100533496; hsa:201158; Q3LIC7; Q96ET8" "" "" "0" "0" "0.876" "0.782" "1.136" "1.037" "0.804" "1.128" "0.967" "0.862" "1.102" "74.2" "65.0" "58.0" "84.3" "76.9" "59.6" "83.7" "71.7" "64.0" "81.7" "" "" "" "" "" "" "" "" "" "" "67.0" "50.2" "44.9" "56.7" "64.2" "50.9" "71.0" "51.9" "43.2" "81.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4955977949004154122" "False" "Medium" "IsMasterProtein" "Q9NRW3" "DNA dC->dU-editing enzyme APOBEC-3C OS=Homo sapiens OX=9606 GN=APOBEC3C PE=1 SV=2" "0.016" "False" "1.906" "7" "1" "1" "1" "190" "22.8" "7.59" "0.00" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf18782" "27350" "ENSG00000244509" "APOBEC3C" "B2R884; hsa:27350; Q5JZ92; Q7Z2N7; Q96F12; Q9NRW3" "Formation of the Editosome" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "High" "High" "1" "" "6981567354116466271" "False" "Medium" "IsMasterProtein" "O43542" "DNA repair protein XRCC3 OS=Homo sapiens OX=9606 GN=XRCC3 PE=1 SV=1" "0.016" "False" "1.904" "3" "1" "1" "1" "346" "37.8" "8.48" "1.74" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7517" "ENSG00000126215" "XRCC3" "hsa:7517; O43542; O43568; Q9BU18" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange" "Fluoropyrimidine activity; Male infertility" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100203530818565223" "False" "Medium" "IsMasterProtein" "O00443" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2" "0.016" "False" "1.901" "0" "1" "1" "1" "1686" "190.6" "8.02" "2.94" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5286" "ENSG00000011405" "PIK3C2A" "B0LPH2; B4E2G4; hsa:5286; O00443; Q14CQ9" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500960934407520232" "False" "Medium" "IsMasterProtein" "O43716" "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1" "0.016" "False" "1.898" "7" "1" "1" "1" "136" "15.1" "5.05" "2.34" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf02686" "283459" "ENSG00000257218" "GATC" "B3KSU7; hsa:283459; O43716; Q3B824; Q3KNR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654723519218057862" "False" "Medium" "IsMasterProtein" "Q9BXB5" "Oxysterol-binding protein-related protein 10 OS=Homo sapiens OX=9606 GN=OSBPL10 PE=1 SV=2" "0.016" "False" "1.885" "2" "1" "1" "1" "764" "83.9" "8.31" "1.72" "1" "other metabolic processes;transport" "other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "114884" "ENSG00000144645" "OSBPL10" "B4E212; hsa:114884; Q9BTU5; Q9BXB5" "Acyl chain remodelling of PS" "" "1" "0" "0.989" "1.834" "1.204" "1.008" "1.502" "0.719" "0.768" "1.582" "7.333" "7.9" "7.8" "14.5" "9.5" "7.9" "11.8" "5.7" "6.1" "12.5" "57.8" "" "" "" "" "" "" "" "" "" "" "7.1" "6.0" "11.2" "6.4" "6.6" "10.1" "4.8" "4.4" "8.4" "57.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5113146668834443448" "False" "Medium" "IsMasterProtein" "Q9NRG4" "N-lysine methyltransferase SMYD2 OS=Homo sapiens OX=9606 GN=SMYD2 PE=1 SV=2" "0.016" "False" "1.881" "3" "1" "2" "1" "433" "49.7" "6.71" "4.40" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00856, Pf01753" "56950" "ENSG00000143499" "SMYD2" "B2R9P9; hsa:56950; I6L9H7; Q4V765; Q5VSH9; Q96AI4; Q9NRG4" "PKMTs methylate histone lysines; Regulation of TP53 Activity through Methylation" "Histone modifications" "3" "0" "1.563" "1.624" "1.242" "1.170" "1.182" "1.440" "0.903" "1.343" "0.865" "20.6" "32.2" "33.4" "25.6" "24.1" "24.4" "29.7" "18.6" "27.7" "17.8" "" "" "" "" "" "" "" "" "" "" "18.6" "24.8" "25.9" "17.2" "20.1" "20.8" "25.2" "13.5" "18.7" "17.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8713380436033100522" "False" "Medium" "IsMasterProtein" "Q71SY5" "Mediator of RNA polymerase II transcription subunit 25 OS=Homo sapiens OX=9606 GN=MED25 PE=1 SV=2" "0.016" "False" "1.880" "1" "1" "1" "1" "747" "78.1" "8.34" "2.98" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11232, Pf11235, Pf11265" "81857" "ENSG00000104973" "MED25" "A8K095; B9TX30; hsa:81857; O95783; Q6P143; Q6QMH5; Q707U4; Q71SY5; Q8TB55; Q9H0L5; Q9HB34" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3567158229513091577" "False" "Medium" "IsMasterProtein" "Q8NDX1" "PH and SEC7 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PSD4 PE=1 SV=2" "0.016" "False" "1.878" "1" "1" "1" "1" "1056" "116.2" "5.48" "2.22" "1" "other biological processes" "plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf01369, Pf15410" "23550" "ENSG00000125637" "PSD4" "A6NEG7; A8K1Y0; hsa:23550; O95621; Q4ZG34; Q6GPH8; Q8IYP4; Q8NDX1" "" "2q13 copy number variation syndrome" "1" "0" "1.055" "0.958" "1.071" "1.000" "0.948" "1.061" "0.910" "1.040" "4.058" "46.3" "48.9" "44.4" "49.6" "46.3" "43.9" "49.2" "42.2" "48.2" "188.0" "" "" "" "" "" "" "" "" "" "" "41.8" "37.7" "34.3" "33.4" "38.6" "37.5" "41.7" "30.5" "32.5" "188.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "813954222595635444" "False" "Medium" "IsMasterProtein" "Q9H668" "CST complex subunit STN1 OS=Homo sapiens OX=9606 GN=STN1 PE=1 SV=2" "0.016" "False" "1.877" "3" "1" "2" "1" "368" "42.1" "6.07" "5.16" "1" "cell organization and biogenesis;DNA metabolism;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf01336, Pf09170" "79991" "ENSG00000107960" "STN1" "D3DR99; hsa:79991; Q5TCZ0; Q9H668" "Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation" "Lung fibrosis" "3" "0" "1.024" "0.962" "0.996" "0.897" "0.996" "0.976" "0.969" "1.117" "0.604" "144.3" "147.8" "138.8" "143.7" "129.4" "143.7" "140.9" "139.8" "161.1" "87.1" "" "" "" "" "" "" "" "" "" "" "130.2" "114.0" "107.4" "96.7" "107.9" "122.6" "119.5" "101.2" "108.7" "87.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1398033593130895886" "False" "Medium" "IsMasterProtein" "O43264" "Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3" "0.016" "False" "1.876" "2" "1" "1" "1" "779" "88.8" "6.27" "1.81" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf06248, Pf20665, Pf20666" "9183" "ENSG00000086827" "ZW10" "A1A528; hsa:9183; O43264" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "7" "0" "1.064" "1.464" "1.190" "1.196" "0.803" "1.020" "1.421" "0.884" "2.023" "13.5" "14.4" "19.8" "16.1" "16.2" "10.9" "13.8" "19.2" "12.0" "27.4" "" "" "" "" "" "" "" "" "" "" "12.2" "11.1" "15.3" "10.8" "13.5" "9.3" "11.7" "13.9" "8.1" "27.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1851911761268984934" "False" "Medium" "IsMasterProtein" "O00418" "Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2" "0.016" "False" "1.876" "1" "1" "1" "1" "725" "82.1" "5.33" "2.79" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf02816" "29904" "ENSG00000103319" "EEF2K" "hsa:29904; O00418; Q8N588" "mTORC1-mediated signalling" "Translation factors; AMP-activated protein kinase signaling; BDNF-TrkB signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634766023329637374" "False" "Medium" "IsMasterProtein" "Q9HAF1" "Chromatin modification-related protein MEAF6 OS=Homo sapiens OX=9606 GN=MEAF6 PE=1 SV=1" "0.016" "False" "1.875" "4" "1" "1" "1" "191" "21.6" "9.32" "2.78" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf09340" "64769" "ENSG00000163875" "MEAF6" "B1AK64; hsa:64769; Q4F967; Q7Z311; Q86WE3; Q9HAF1" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431062919970507924" "False" "Medium" "IsMasterProtein" "P62891" "Large ribosomal subunit protein eL39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2" "0.016" "False" "1.864" "20" "1" "1" "1" "51" "6.4" "12.56" "0.00" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00832" "6170" "ENSG00000198918" "RPL39" "hsa:6170; P02404; P39025; P62891; Q9BYF2" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "Cytoplasmic ribosomal proteins" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3166111857838769824" "False" "Medium" "IsMasterProtein" "P46531" "Neurogenic locus notch homolog protein 1 OS=Homo sapiens OX=9606 GN=NOTCH1 PE=1 SV=4" "0.016" "False" "1.862" "0" "1" "1" "1" "2555" "272.3" "5.12" "2.89" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00008, Pf00066, Pf06816, Pf07645, Pf07684, Pf12661, Pf12796, Pf13637" "4851" "ENSG00000148400" "NOTCH1" "hsa:4851; P46531; Q59ED8; Q5SXM3" "Regulation of NFE2L2 gene expression; NOTCH4 Intracellular Domain Regulates Transcription; Formation of paraxial mesoderm; Somitogenesis; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Pre-NOTCH Processing in Golgi; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating tumorigenic genes; Pre-NOTCH Processing in the Endoplasmic Reticulum; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling; Defective LFNG causes SCDO3; RUNX3 regulates NOTCH signaling" "Heart development; Neural crest differentiation; Gastric cancer network 1; Cardiac progenitor differentiation; Primary focal segmental glomerulosclerosis (FSGS); Notch signaling; Pluripotent stem cell differentiation pathway; Hematopoietic stem cell differentiation; Endoderm differentiation; Gene regulatory network modeling somitogenesis ; NOTCH1 regulation of endothelial cell calcification; Pathways affected in adenoid cystic carcinoma; Amplification and expansion of oncogenic pathways as metastatic traits; Canonical and non-canonical Notch signaling; BMP signaling in eyelid development; OSX and miRNAs in tooth development; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Somitogenesis in the context of spondylocostal dysostosis; Osteoblast differentiation and related diseases; Overlap between signal transduction pathways contributing to LMNA laminopathies; p53 transcriptional gene network; DYRK1A involvement regarding cell proliferation in brain development; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Neurogenesis regulation in the olfactory epithelium; Genetic causes of porto-sinusoidal vascular disease; TROP2 regulatory signaling; Cell lineage map for neuronal differentiation; Notch signaling pathway" "53" "0" "0.946" "1.028" "1.179" "0.966" "0.927" "1.060" "0.966" "1.067" "1.919" "216.7" "205.1" "222.8" "255.5" "209.4" "200.8" "229.6" "209.2" "231.3" "415.8" "" "" "" "" "" "" "" "" "" "" "195.6" "158.2" "172.3" "172.0" "174.6" "171.4" "194.8" "151.4" "156.0" "415.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124474899174263242" "False" "Medium" "IsMasterProtein" "Q08AF3" "Schlafen family member 5 OS=Homo sapiens OX=9606 GN=SLFN5 PE=1 SV=1" "0.016" "False" "1.862" "1" "1" "1" "1" "891" "101.0" "8.22" "2.85" "1" "other biological processes" "nucleus" "other molecular function" "Pf04326, Pf09848, Pf17057, Pf21026" "162394" "ENSG00000166750" "SLFN5" "hsa:162394; Q08AF2; Q08AF3; Q8WU54; Q96A82" "" "17q12 copy number variation syndrome" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1862365170183324257" "False" "Medium" "IsMasterProtein" "P56182" "Ribosomal RNA processing protein 1 homolog A OS=Homo sapiens OX=9606 GN=RRP1 PE=1 SV=1" "0.016" "False" "1.861" "3" "1" "1" "1" "461" "52.8" "9.33" "2.78" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf05997" "8568" "ENSG00000160214" "RRP1" "hsa:8568; P56182; Q9NST5" "Major pathway of rRNA processing in the nucleolus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874142018275296018" "False" "Medium" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "0.016" "False" "1.858" "0" "1" "1" "1" "2005" "226.2" "7.30" "2.32" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4019435844159720202" "False" "Medium" "IsMasterProtein" "P84074" "Neuron-specific calcium-binding protein hippocalcin OS=Homo sapiens OX=9606 GN=HPCA PE=1 SV=2" "0.016" "False" "1.857" "6" "1" "1" "1" "193" "22.4" "4.97" "2.02" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;other molecular function" "Pf00036, Pf13499" "3208" "ENSG00000121905" "HPCA" "B2R9T3; D3DPQ7; hsa:3208; P32076; P41211; P70510; P84074" "" "Opioid receptor pathways" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7612654384258451191" "False" "Medium" "IsMasterProtein" "Q13571" "Lysosomal-associated transmembrane protein 5 OS=Homo sapiens OX=9606 GN=LAPTM5 PE=1 SV=1" "0.016" "False" "1.856" "5" "1" "1" "1" "262" "29.9" "8.68" "2.67" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03821" "7805" "ENSG00000162511" "LAPTM5" "hsa:7805; Q13240; Q13571; Q14698; Q3KP54" "" "" "0" "0" "1.186" "0.969" "1.071" "1.082" "0.983" "0.906" "0.849" "0.952" "0.803" "34.4" "40.8" "33.4" "36.9" "37.3" "33.8" "31.2" "29.2" "32.8" "27.6" "" "" "" "" "" "" "" "" "" "" "31.1" "31.5" "25.8" "24.8" "31.1" "28.9" "26.5" "21.2" "22.1" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "53418054531759760" "False" "Medium" "IsMasterProtein" "Q86Y79" "Peptidyl-tRNA hydrolase OS=Homo sapiens OX=9606 GN=PTRH1 PE=1 SV=1" "0.016" "False" "1.852" "4" "1" "1" "1" "214" "22.9" "10.56" "1.85" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "" "other molecular function" "Pf01195" "138428" "ENSG00000187024" "PTRH1" "hsa:138428; Q86Y79" "" "" "0" "0" "0.895" "0.778" "0.852" "0.942" "1.034" "0.953" "0.694" "0.955" "1.051" "43.7" "39.2" "34.0" "37.3" "41.2" "45.2" "41.7" "30.4" "41.8" "46.0" "" "" "" "" "" "" "" "" "" "" "39.5" "30.2" "26.3" "25.1" "34.4" "38.6" "35.4" "22.0" "28.2" "46.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6043463436452304537" "False" "Medium" "IsMasterProtein" "Q5SSJ5" "Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1" "0.017" "False" "1.847" "2" "1" "1" "1" "553" "61.2" "9.67" "2.55" "1" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "50809" "ENSG00000127483" "HP1BP3" "A6NI71; A8K5D7; B3KMZ8; B4E210; hsa:50809; Q05BI0; Q5SSJ5; Q5SSJ6; Q5SWC6; Q6PIM9; Q8NDF0; Q9UHY0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-663031508343712048" "False" "Medium" "IsMasterProtein" "P06681" "Complement C2 OS=Homo sapiens OX=9606 GN=C2 PE=1 SV=2" "0.017" "False" "1.846" "2" "1" "1" "1" "752" "83.2" "7.42" "2.31" "1" "protein metabolism;stress response;other biological processes" "non-structural extracellular" "other molecular function" "Pf00084, Pf00089, Pf00092" "717" "ENSG00000166278; ENSG00000204364; ENSG00000206372; ENSG00000226560; ENSG00000231543; ENSG00000235017; ENSG00000235696" "C2" "B4DPF3; B4DV20; E9PFN7; hsa:717; O19694; P06681; Q13904" "Initial triggering of complement; Regulation of Complement cascade; Activation of C3 and C5" "Allograft rejection; Complement system; Dengue-2 interactions with complement and coagulation cascades; Oxidative damage response; Complement system in neuronal development and plasticity; Complement activation; Complement and coagulation cascades" "10" "0" "1.075" "1.421" "0.977" "1.016" "1.067" "1.205" "1.638" "1.195" "0.909" "31.2" "33.5" "44.3" "30.5" "31.7" "33.3" "37.6" "51.1" "37.3" "28.4" "" "" "" "" "" "" "" "" "" "" "28.2" "25.9" "34.3" "20.5" "26.4" "28.4" "31.9" "37.0" "25.1" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7436482478148807515" "False" "Medium" "IsMasterProtein" "Q86TB9" "Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2" "0.017" "False" "1.845" "1" "1" "1" "1" "770" "86.8" "6.67" "2.97" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf09770" "219988" "ENSG00000166889" "PATL1" "B3KXT9; hsa:219988; Q2TA86; Q6P166; Q86TB9; Q8N9M6; Q8NI63" "mRNA decay by 5' to 3' exoribonuclease" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5881505149205168473" "False" "Medium" "IsMasterProtein" "Q8WXI3" "Ankyrin repeat and SOCS box protein 10 OS=Homo sapiens OX=9606 GN=ASB10 PE=1 SV=2" "0.017" "False" "1.843" "2" "1" "1" "1" "467" "50.9" "7.01" "2.09" "1" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "" "Pf07525, Pf12796" "136371" "ENSG00000146926" "ASB10" "A0AVH0; hsa:136371; Q6ZUL6; Q8WXI3" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1791941812365696393" "False" "Medium" "IsMasterProtein" "Q8WWF8" "Calcyphosin-like protein OS=Homo sapiens OX=9606 GN=CAPSL PE=1 SV=4" "0.017" "False" "1.842" "4" "1" "1" "1" "208" "24.2" "6.05" "2.47" "1" "" "other cell component" "other molecular function" "Pf13499" "133690" "ENSG00000152611" "CAPSL" "hsa:133690; Q8WWF8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8775009623055408679" "False" "Medium" "IsMasterProtein" "Q5BKY9" "Protein FAM133B OS=Homo sapiens OX=9606 GN=FAM133B PE=1 SV=1" "0.017" "False" "1.840" "4" "1" "1" "1" "247" "28.4" "10.02" "2.80" "1" "" "" "" "" "257415" "ENSG00000234545" "FAM133B" "B2R994; hsa:257415; Q05D67; Q5BKY9; Q6P5S6; Q8N0W8" "" "" "0" "0" "0.929" "1.028" "1.089" "1.069" "1.040" "1.109" "1.086" "1.154" "0.879" "62.0" "57.6" "63.8" "67.5" "66.3" "64.5" "68.8" "67.4" "71.6" "54.5" "" "" "" "" "" "" "" "" "" "" "56.0" "44.5" "49.3" "45.5" "55.3" "55.1" "58.4" "48.8" "48.3" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824788000835968644" "False" "Medium" "IsMasterProtein" "O15182" "Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2" "0.017" "False" "1.839" "7" "1" "1" "1" "167" "19.5" "4.74" "1.65" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1070" "ENSG00000153140" "CETN3" "hsa:1070; O15182; Q53YD2; Q9BS23" "" "Breast cancer pathway" "1" "0" "1.163" "1.515" "1.882" "1.149" "1.130" "1.122" "1.271" "1.572" "1.748" "10.1" "11.8" "15.3" "19.0" "11.6" "11.4" "11.4" "12.9" "15.9" "17.7" "" "" "" "" "" "" "" "" "" "" "9.1" "9.1" "11.9" "12.8" "9.7" "9.8" "9.6" "9.3" "10.7" "17.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4771647564776910413" "False" "Medium" "IsMasterProtein" "Q96JC9" "ELL-associated factor 1 OS=Homo sapiens OX=9606 GN=EAF1 PE=1 SV=1" "0.017" "False" "1.839" "3" "1" "2" "1" "268" "29.0" "5.40" "5.46" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09816" "85403" "ENSG00000144597" "EAF1" "B4E3F5; hsa:85403; Q8IW10; Q96JC9" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8571260626068012330" "False" "Medium" "IsMasterProtein" "Q9NXK8" "F-box/LRR-repeat protein 12 OS=Homo sapiens OX=9606 GN=FBXL12 PE=1 SV=1" "0.017" "False" "1.839" "6" "1" "1" "1" "326" "37.0" "8.79" "2.67" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937" "54850" "ENSG00000127452" "FBXL12" "B3KSJ8; hsa:54850; Q9H5K4; Q9NXK8" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "High" "High" "High" "Not Found" "High" "Not Found" "High" "1" "" "-1892947756111346869" "False" "Medium" "IsMasterProtein" "P42345" "Serine/threonine-protein kinase mTOR OS=Homo sapiens OX=9606 GN=MTOR PE=1 SV=1" "0.017" "False" "1.834" "0" "1" "1" "1" "2549" "288.7" "7.17" "3.09" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08771, Pf11865" "2475" "ENSG00000198793" "MTOR" "hsa:2475; P42345; Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; HSF1-dependent transactivation" "AMP-activated protein kinase signaling; Target of rapamycin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Cardiac hypertrophic response; Extracellular vesicle-mediated signaling in recipient cells; TSLP signaling pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ATM signaling in development and disease ; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; CAMKK2 pathway; Neuroinflammation; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Acute myeloid leukemia; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; Interferon type I signaling pathways; ErbB signaling pathway" "92" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2806673757180566722" "False" "Medium" "IsMasterProtein" "P54709" "Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1" "0.017" "False" "1.834" "3" "1" "1" "1" "279" "31.5" "8.35" "2.76" "1" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00287" "483" "ENSG00000069849" "ATP1B3" "B7Z1N7; hsa:483; P54709" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases; Basigin interactions" "Calcium regulation in cardiac cells" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559430331434459476" "False" "Medium" "IsMasterProtein" "O95630" "STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1" "0.017" "False" "1.833" "2" "1" "1" "1" "424" "48.0" "6.29" "2.16" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "10617" "ENSG00000124356" "STAMBP" "B5M0B6; D6W5H7; hsa:10617; O95630; Q3MJE7" "Metalloprotease DUBs" "EGF/EGFR signaling pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4972524321603701932" "False" "Medium" "IsMasterProtein" "Q8IW35" "Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1" "0.017" "False" "1.822" "1" "1" "1" "1" "865" "96.9" "5.02" "3.19" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14580" "79598" "ENSG00000182504" "CEP97" "B5MDY8; hsa:79598; Q8IW35; Q8NA71; Q9H5T9" "Anchoring of the basal body to the plasma membrane; RHOV GTPase cycle" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8122184501551353547" "False" "Medium" "IsMasterProtein" "Q9NZI8" "Insulin-like growth factor 2 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=IGF2BP1 PE=1 SV=2" "0.017" "False" "1.818" "1" "1" "1" "1" "577" "63.4" "9.20" "2.48" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10642" "ENSG00000159217" "IGF2BP1" "C9JT33; hsa:10642; Q9NZI8" "MAPK6/MAPK4 signaling; Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "Brain-derived neurotrophic factor (BDNF) signaling pathway; eIF5A regulation in response to inhibition of the nuclear export system" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687201697740038391" "False" "Medium" "IsMasterProtein" "Q9NP92" "Large ribosomal subunit protein mL65 OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" "0.017" "False" "1.806" "2" "1" "2" "1" "439" "50.3" "7.97" "5.11" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "10884" "ENSG00000112996" "MRPS30" "hsa:10884; Q96I91; Q96Q19; Q9H0P8; Q9NP92; Q9NSF9; Q9NZ76" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "1.002" "0.846" "0.873" "1.044" "0.872" "0.914" "0.836" "0.896" "0.772" "123.0" "123.2" "104.1" "107.3" "128.4" "107.2" "112.4" "102.8" "110.2" "94.9" "" "" "" "" "" "" "" "" "" "" "111.0" "95.0" "80.5" "72.3" "107.1" "91.5" "95.4" "74.4" "74.3" "94.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5860754846925802701" "False" "Medium" "IsMasterProtein" "O95400" "CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1" "0.017" "False" "1.803" "2" "1" "1" "1" "341" "37.6" "4.61" "2.58" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02213" "10421" "ENSG00000169217" "CD2BP2" "B2RDX2; hsa:10421; O95400; Q9ULP2" "" "mRNA processing; Ciliary landscape" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8487408262660345487" "False" "Medium" "IsMasterProtein" "P11388" "DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3" "0.017" "False" "1.799" "1" "1" "1" "1" "1531" "174.3" "8.72" "1.97" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7153" "ENSG00000131747" "TOP2A" "B2RTS1; hsa:7153; P11388; Q71UN1; Q71UQ5; Q9HB24; Q9HB25; Q9HB26; Q9UP44; Q9UQP9" "SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex" "Gastric cancer network 1; Gastric cancer network 2; Retinoblastoma gene in cancer" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5852345656663566721" "False" "Medium" "IsMasterProtein" "Q5JSL3" "Dedicator of cytokinesis protein 11 OS=Homo sapiens OX=9606 GN=DOCK11 PE=1 SV=2" "0.017" "False" "1.796" "1" "1" "1" "1" "2073" "237.5" "7.74" "2.23" "1" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "139818" "ENSG00000147251" "DOCK11" "A6NMF0; hsa:139818; Q5JSL3; Q66M66; Q6ZUJ5; Q86VU8; Q96MN3" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RAC1 GTPase cycle" "" "3" "0" "0.896" "1.406" "1.052" "1.256" "1.111" "0.991" "0.960" "0.967" "1.449" "48.1" "43.1" "67.7" "50.6" "60.5" "53.5" "47.7" "46.2" "46.6" "69.8" "" "" "" "" "" "" "" "" "" "" "43.5" "33.3" "52.4" "34.1" "50.4" "45.7" "40.5" "33.5" "31.4" "69.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4655798141038654615" "False" "Medium" "IsMasterProtein" "Q8N6N3" "UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1" "0.018" "False" "1.788" "5" "1" "1" "1" "182" "20.6" "5.21" "2.79" "1" "" "nucleus" "" "Pf15559" "148423" "ENSG00000162642" "C1orf52" "B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6" "" "" "0" "0" "1.175" "1.151" "1.405" "1.144" "1.111" "1.013" "1.118" "1.308" "0.898" "69.6" "81.7" "80.1" "97.7" "79.5" "77.3" "70.5" "77.8" "91.0" "62.5" "" "" "" "" "" "" "" "" "" "" "62.8" "63.0" "61.9" "65.8" "66.4" "66.0" "59.8" "56.3" "61.4" "62.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-419593273491942870" "False" "Medium" "IsMasterProtein" "P0C7P3" "Protein SLFN14 OS=Homo sapiens OX=9606 GN=SLFN14 PE=1 SV=2" "0.018" "False" "1.785" "1" "1" "1" "1" "912" "103.8" "8.24" "2.35" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04326, Pf17057, Pf21026" "342618" "ENSG00000236320" "SLFN14" "B2RTW9; hsa:342618; P0C7P3" "" "17q12 copy number variation syndrome" "1" "0" "0.984" "1.027" "1.144" "1.277" "1.061" "1.090" "0.940" "1.104" "0.651" "42.9" "42.2" "44.0" "49.0" "54.7" "45.5" "46.7" "40.3" "47.3" "27.9" "" "" "" "" "" "" "" "" "" "" "38.7" "32.5" "34.1" "33.0" "45.6" "38.8" "39.6" "29.1" "31.9" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8915529179723180777" "False" "Medium" "IsMasterProtein" "P00325" "All-trans-retinol dehydrogenase [NAD(+)] ADH1B OS=Homo sapiens OX=9606 GN=ADH1B PE=1 SV=3" "0.018" "False" "1.784" "2" "1" "2" "1" "375" "39.8" "8.19" "4.83" "1" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00107, Pf08240" "125" "ENSG00000196616" "ADH1B" "A8MYN5; B4DRS9; B4DVC3; hsa:125; P00325; Q13711; Q4ZGI9; Q96KI7" "Ethanol oxidation" "Fatty acid omega-oxidation; Ethanol effects on histone modifications" "3" "0" "1.088" "1.259" "1.255" "1.136" "1.044" "1.237" "1.159" "1.184" "0.895" "218.5" "237.7" "275.1" "274.2" "248.3" "228.1" "270.3" "253.2" "258.7" "195.5" "" "" "" "" "" "" "" "" "" "" "197.2" "183.4" "212.7" "184.6" "207.1" "194.7" "229.3" "183.2" "174.5" "195.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8582055952074288165" "False" "Medium" "IsMasterProtein" "Q96QD8" "Sodium-coupled neutral amino acid symporter 2 OS=Homo sapiens OX=9606 GN=SLC38A2 PE=1 SV=2" "0.018" "False" "1.782" "3" "1" "1" "1" "506" "56.0" "8.00" "2.24" "1" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf01490" "54407" "ENSG00000134294" "SLC38A2" "hsa:54407; Q6IA88; Q6ZMG2; Q96QD8; Q9HAV3; Q9NVA8; Q9P2G5" "Glutamate Neurotransmitter Release Cycle; Amino acid transport across the plasma membrane" "Endochondral ossification; Endochondral ossification with skeletal dysplasias; Neuroinflammation and glutamatergic signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251219974824346079" "False" "Medium" "IsMasterProtein" "Q05D32" "CTD small phosphatase-like protein 2 OS=Homo sapiens OX=9606 GN=CTDSPL2 PE=1 SV=2" "0.018" "False" "1.779" "3" "1" "1" "1" "466" "53.0" "6.40" "2.61" "1" "transport;other biological processes" "nucleus" "other molecular function" "Pf03031" "51496" "ENSG00000137770" "CTDSPL2" "hsa:51496; Q05D32; Q3ZTU1; Q6AI06; Q8IYI9; Q9NVT2; Q9NZX8; Q9P030" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2670793063602377093" "False" "Medium" "IsMasterProtein" "Q8TBZ6" "tRNA methyltransferase 10 homolog A OS=Homo sapiens OX=9606 GN=TRMT10A PE=1 SV=1" "0.018" "False" "1.778" "2" "1" "1" "1" "339" "39.7" "7.65" "2.80" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01746" "93587" "ENSG00000145331" "TRMT10A" "B2R8X7; hsa:93587; Q8TBZ6; Q9Y2T9" "tRNA modification in the nucleus and cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3562387644317083347" "False" "Medium" "IsMasterProtein" "Q8N3C0" "Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3" "0.018" "False" "1.774" "0" "1" "1" "1" "2202" "251.3" "7.09" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf02889" "10973" "ENSG00000112249" "ASCC3" "E7EW23; hsa:10973; O43738; Q4G1A0; Q5VTN2; Q8N3C0; Q9H1I9; Q9H5A2; Q9NTR0" "ALKBH3 mediated reversal of alkylation damage" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952210186294942098" "False" "Medium" "IsMasterProtein" "O15315" "DNA repair protein RAD51 homolog 2 OS=Homo sapiens OX=9606 GN=RAD51B PE=1 SV=2" "0.018" "False" "1.771" "2" "1" "1" "1" "384" "42.2" "5.69" "2.20" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5890" "ENSG00000182185" "RAD51B" "hsa:5890; O15315; O60914; O75210; Q3Y4F8; Q6FHX8; Q86SY3; Q86SY4; Q86TR0; Q86U92; Q86U93; Q86U94; Q8N6H4; Q9UPL5" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5609078604117945067" "False" "Medium" "IsMasterProtein" "Q9H777" "Zinc phosphodiesterase ELAC protein 1 OS=Homo sapiens OX=9606 GN=ELAC1 PE=1 SV=2" "0.018" "False" "1.770" "2" "1" "1" "1" "363" "40.0" "6.79" "3.50" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00753" "55520" "ENSG00000141642" "ELAC1" "hsa:55520; Q9H777; Q9NS99" "" "" "0" "0" "1.012" "1.117" "1.073" "1.079" "0.923" "1.132" "1.129" "1.443" "0.773" "153.6" "155.5" "171.6" "164.9" "165.8" "141.8" "173.9" "173.4" "221.7" "118.8" "" "" "" "" "" "" "" "" "" "" "138.7" "120.0" "132.7" "111.0" "138.3" "121.0" "147.5" "125.5" "149.5" "118.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5201003566343787009" "False" "Medium" "IsMasterProtein" "P62273" "Small ribosomal subunit protein uS14 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2" "0.018" "False" "1.769" "13" "1" "1" "1" "56" "6.7" "10.13" "2.48" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00253" "6235" "ENSG00000213741" "RPS29" "A8MZ73; hsa:6235; P30054; P62273" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "Cytoplasmic ribosomal proteins" "19" "0" "1.041" "1.325" "1.199" "1.522" "1.306" "1.292" "1.132" "1.091" "0.523" "116.9" "121.6" "154.9" "140.2" "177.9" "152.7" "151.1" "132.3" "127.5" "61.2" "" "" "" "" "" "" "" "" "" "" "105.5" "93.8" "119.8" "94.4" "148.4" "130.3" "128.2" "95.8" "86.0" "61.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579603406694116788" "False" "Medium" "IsMasterProtein" "Q9H0C5" "BTB/POZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BTBD1 PE=1 SV=1" "0.018" "False" "1.764" "2" "1" "1" "1" "482" "52.7" "6.10" "1.67" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf07707, Pf08005" "53339" "ENSG00000064726" "BTBD1" "A6NMI8; hsa:53339; Q9BX71; Q9H0C5; Q9NWN4" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "15q25 copy number variation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2325443013124673649" "False" "Medium" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "0.019" "False" "1.759" "1" "1" "1" "1" "501" "54.1" "6.24" "2.70" "1" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "0.894" "0.613" "1.112" "0.940" "0.692" "0.983" "0.392" "0.837" "6.060" "89.5" "80.0" "54.8" "99.4" "84.1" "61.9" "88.0" "35.1" "74.9" "542.2" "" "" "" "" "" "" "" "" "" "" "80.8" "61.7" "42.4" "67.0" "70.1" "52.9" "74.6" "25.4" "50.5" "542.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1754364891435956816" "False" "Medium" "IsMasterProtein" "Q8NG68" "Tubulin--tyrosine ligase OS=Homo sapiens OX=9606 GN=TTL PE=1 SV=2" "0.019" "False" "1.756" "3" "1" "1" "1" "377" "43.2" "6.74" "2.49" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton" "other molecular function" "Pf03133" "150465" "ENSG00000114999" "TTL" "hsa:150465; Q585T3; Q7Z302; Q8N426; Q8NG68" "Carboxyterminal post-translational modifications of tubulin" "2q13 copy number variation syndrome" "2" "0" "0.876" "0.612" "0.796" "1.025" "1.015" "0.986" "1.130" "0.957" "0.725" "27.5" "24.1" "16.8" "21.9" "28.2" "27.9" "27.1" "31.1" "26.3" "19.9" "" "" "" "" "" "" "" "" "" "" "24.8" "18.6" "13.0" "14.7" "23.5" "23.8" "23.0" "22.5" "17.8" "19.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198167910452048535" "False" "Medium" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=3" "0.019" "False" "1.755" "2" "1" "1" "1" "633" "69.5" "6.28" "3.10" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01834" "7515" "ENSG00000073050" "XRCC1" "hsa:7515; P18887; Q6IBS4; Q9HCB1" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1620287855834413498" "False" "Medium" "IsMasterProtein" "Q86XE3" "Calcium uptake protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=MICU3 PE=1 SV=1" "0.019" "False" "1.750" "2" "1" "2" "1" "530" "60.7" "8.21" "5.47" "1" "transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13499" "286097" "ENSG00000155970" "MICU3" "hsa:286097; Q86XE3; Q8IYZ3" "Processing of SMDT1" "" "2" "0" "1.073" "0.996" "1.105" "1.063" "1.000" "1.023" "1.078" "1.080" "0.860" "196.2" "210.5" "195.3" "216.7" "208.6" "196.2" "200.8" "211.4" "211.8" "168.7" "" "" "" "" "" "" "" "" "" "" "177.1" "162.4" "151.1" "146.0" "174.0" "167.5" "170.3" "153.0" "142.9" "168.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4251448213258872513" "False" "Medium" "IsMasterProtein" "Q8WV93" "AFG1-like ATPase OS=Homo sapiens OX=9606 GN=AFG1L PE=1 SV=2" "0.019" "False" "1.750" "2" "1" "1" "1" "481" "54.8" "7.27" "1.97" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf03969" "246269" "ENSG00000135537" "AFG1L" "hsa:246269; Q8N6A3; Q8WV93" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6085162609898003873" "False" "Medium" "IsMasterProtein" "Q9Y6M5" "Proton-coupled zinc antiporter SLC30A1 OS=Homo sapiens OX=9606 GN=SLC30A1 PE=1 SV=3" "0.019" "False" "1.749" "2" "1" "1" "1" "507" "55.3" "6.48" "2.22" "1" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf01545" "7779" "ENSG00000170385" "SLC30A1" "hsa:7779; Q0VAK9; Q9BZF6; Q9Y6M5" "Zinc efflux and compartmentalization by the SLC30 family" "Zinc homeostasis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2990327377986760395" "False" "Medium" "IsMasterProtein" "Q8N9Q2" "Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1" "0.019" "False" "1.749" "5" "1" "1" "1" "155" "18.2" "9.85" "3.14" "1" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf13917" "285672" "ENSG00000153006" "SREK1IP1" "hsa:285672; Q32NC8; Q8N9Q2" "" "" "0" "0" "0.831" "0.917" "0.898" "0.897" "0.934" "0.942" "0.910" "0.945" "0.757" "139.1" "115.6" "127.6" "124.9" "124.7" "129.8" "130.9" "126.5" "131.4" "105.3" "" "" "" "" "" "" "" "" "" "" "125.5" "89.1" "98.7" "84.1" "104.0" "110.8" "111.1" "91.6" "88.6" "105.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139245110499108060" "False" "Medium" "IsMasterProtein" "P32942" "Intercellular adhesion molecule 3 OS=Homo sapiens OX=9606 GN=ICAM3 PE=1 SV=2" "0.019" "False" "1.748" "1" "1" "1" "1" "547" "59.5" "5.43" "3.37" "1" "cell adhesion;transport" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf03921, Pf21146" "3385" "ENSG00000076662" "ICAM3" "hsa:3385; P32942; Q6PD68" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; CD209 (DC-SIGN) signaling" "Ebola virus infection in host" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2282593962912776213" "False" "Medium" "IsMasterProtein" "Q15853" "Upstream stimulatory factor 2 OS=Homo sapiens OX=9606 GN=USF2 PE=1 SV=1" "0.019" "False" "1.744" "2" "1" "1" "1" "346" "36.9" "5.10" "2.93" "1" "transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7392" "ENSG00000105698" "USF2" "hsa:7392; O00671; O00709; Q05750; Q07952; Q15851; Q15852; Q15853; Q6FI33; Q6YI47" "Estrogen-dependent gene expression" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "2" "0" "0.986" "0.884" "1.115" "1.138" "0.846" "0.980" "1.063" "0.870" "0.750" "118.2" "116.5" "104.5" "131.8" "134.6" "100.0" "115.9" "125.6" "102.8" "88.7" "" "" "" "" "" "" "" "" "" "" "106.7" "89.9" "80.8" "88.8" "112.3" "85.4" "98.3" "90.9" "69.4" "88.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414895648230328268" "False" "Medium" "IsMasterProtein" "Q92667" "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" "0.020" "False" "1.740" "2" "1" "1" "1" "903" "97.3" "4.94" "2.98" "1" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00013, Pf00567" "8165" "ENSG00000121057" "AKAP1" "A8K8Q1; D3DTZ0; hsa:8165; Q13320; Q92667; Q9BW14" "Factors involved in megakaryocyte development and platelet production; Mitochondrial calcium ion transport" "G protein signaling pathways" "3" "0" "0.965" "1.424" "1.047" "0.900" "1.346" "0.885" "0.961" "1.429" "2.110" "193.3" "186.5" "275.2" "202.5" "174.0" "260.2" "171.1" "185.8" "276.3" "407.9" "" "" "" "" "" "" "" "" "" "" "174.5" "143.8" "212.8" "136.3" "145.2" "222.0" "145.2" "134.5" "186.3" "407.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5162723049460562380" "False" "Medium" "IsMasterProtein" "Q9BPU6" "Dihydropyrimidinase-related protein 5 OS=Homo sapiens OX=9606 GN=DPYSL5 PE=1 SV=1" "0.020" "False" "1.739" "1" "1" "1" "1" "564" "61.4" "7.20" "2.62" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01979" "56896" "ENSG00000157851" "DPYSL5" "hsa:56896; Q8TCL6; Q9BPU6; Q9NQC4; Q9NRY9" "CRMPs in Sema3A signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719462215085106760" "False" "Medium" "IsMasterProtein" "Q8N983" "Large ribosomal subunit protein mL43 OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" "0.020" "False" "1.735" "3" "1" "1" "1" "215" "23.4" "8.65" "2.50" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "84545" "ENSG00000055950" "MRPL43" "B1AL06; B1AL07; B1AL09; B1AL10; C9J5Q3; D3DR71; hsa:84545; Q5JW06; Q7Z719; Q7Z7H6; Q86XN1; Q8N983; Q9BYC7" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5652350861994780505" "False" "Medium" "IsMasterProtein" "Q13480" "GRB2-associated-binding protein 1 OS=Homo sapiens OX=9606 GN=GAB1 PE=1 SV=2" "0.020" "False" "1.734" "2" "1" "1" "1" "694" "76.6" "5.96" "2.20" "1" "developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00169" "2549" "ENSG00000109458" "GAB1" "A8K152; hsa:2549; Q13480; Q4W5G2; Q6P1W2" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; MET activates RAP1 and RAC1; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); PI3K Cascade; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by FGFR1 in disease; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; MET activates PI3K/AKT signaling; MET activates PTPN11; MET receptor recycling; Activated NTRK2 signals through PI3K" "Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Alpha 6 beta 4 signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; BDNF-TrkB signaling; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway" "46" "0" "0.718" "0.798" "0.506" "0.903" "0.924" "0.880" "0.961" "0.602" "1.132" "19.4" "13.9" "15.5" "9.8" "17.5" "17.9" "17.1" "18.6" "11.7" "21.9" "" "" "" "" "" "" "" "" "" "" "17.5" "10.7" "12.0" "6.6" "14.6" "15.3" "14.5" "13.5" "7.9" "21.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3835661040312072050" "False" "Medium" "IsMasterProtein" "Q9BUA3" "Spindlin interactor and repressor of chromatin-binding protein OS=Homo sapiens OX=9606 GN=SPINDOC PE=1 SV=3" "0.020" "False" "1.731" "2" "1" "1" "1" "381" "41.0" "5.01" "2.62" "1" "stress response;other biological processes" "nucleus;other cell component" "" "Pf18658" "144097" "ENSG00000168005" "SPINDOC" "hsa:144097; Q68CV7; Q6PHS2; Q96IH0; Q9BUA3" "" "" "0" "0" "1.072" "1.081" "1.284" "1.045" "1.040" "1.091" "1.070" "1.193" "1.195" "93.1" "99.8" "100.6" "119.5" "97.3" "96.9" "101.6" "99.6" "111.1" "111.3" "" "" "" "" "" "" "" "" "" "" "84.0" "77.0" "77.8" "80.5" "81.1" "82.7" "86.2" "72.1" "74.9" "111.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7554911446023016001" "False" "Medium" "IsMasterProtein" "P51668" "Ubiquitin-conjugating enzyme E2 D1 OS=Homo sapiens OX=9606 GN=UBE2D1 PE=1 SV=1" "0.020" "False" "1.729" "5" "1" "1" "1" "147" "16.6" "7.42" "2.30" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7321" "ENSG00000072401" "UBE2D1" "A6NLF6; A8K786; hsa:7321; P51668" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Peroxisomal protein import; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CLEC7A (Dectin-1) signaling; CDK-mediated phosphorylation and removal of Cdc6; Neddylation; IKK complex recruitment mediated by RIP1; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Signaling by BMP; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Ovarian tumor domain proteases" "Proteasome degradation" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3570886289104636423" "False" "Medium" "IsMasterProtein" "Q9NYP9" "Protein Mis18-alpha OS=Homo sapiens OX=9606 GN=MIS18A PE=1 SV=1" "0.020" "False" "1.727" "3" "1" "1" "1" "233" "25.8" "5.20" "2.86" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03226" "54069" "ENSG00000159055" "MIS18A" "B2R562; hsa:54069; Q542Z0; Q9NYP9" "Deposition of new CENPA-containing nucleosomes at the centromere" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619472182958520531" "False" "Medium" "IsMasterProtein" "P61960" "Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1" "0.020" "False" "1.725" "8" "1" "1" "1" "85" "9.1" "9.31" "2.49" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf03671" "51569" "ENSG00000120686" "UFM1" "hsa:51569; P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2" "" "" "0" "0" "0.839" "1.055" "0.867" "0.872" "0.939" "0.959" "0.989" "0.877" "0.638" "204.7" "171.8" "216.0" "177.5" "178.4" "192.1" "196.3" "202.4" "179.5" "130.5" "" "" "" "" "" "" "" "" "" "" "184.8" "132.5" "167.1" "119.6" "148.8" "164.0" "166.5" "146.5" "121.1" "130.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6165163621982420395" "False" "Medium" "IsMasterProtein" "P42694" "Probable helicase with zinc finger domain OS=Homo sapiens OX=9606 GN=HELZ PE=1 SV=2" "0.020" "False" "1.721" "1" "1" "1" "1" "1942" "218.8" "7.42" "0.00" "1" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00642, Pf13086, Pf13087" "9931" "ENSG00000198265" "HELZ" "hsa:9931; I6L9H4; P42694" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5442629486260098393" "False" "Medium" "IsMasterProtein" "Q05397" "Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2" "0.020" "False" "1.719" "1" "1" "1" "1" "1052" "119.2" "6.62" "2.26" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "5747" "ENSG00000169398" "PTK2" "B4E2N6; F5H4S4; hsa:5747; J3QT16; Q05397; Q14291; Q8IYN9; Q9UD85" "RAF/MAP kinase cascade; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Signal regulatory protein family interactions; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; MET activates PTK2 signaling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Apoptotic cleavage of cellular proteins" "Androgen receptor signaling pathway; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Corticotropin-releasing hormone signaling pathway; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Overview of nanoparticle effects; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Hippo-Merlin signaling dysregulation; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Small cell lung cancer; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; 2q13 copy number variation syndrome; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; ErbB signaling pathway" "51" "0" "1.028" "0.855" "0.920" "0.962" "1.055" "0.925" "0.989" "0.947" "0.812" "79.2" "81.4" "67.7" "72.8" "76.2" "83.6" "73.3" "78.3" "75.0" "64.3" "" "" "" "" "" "" "" "" "" "" "71.5" "62.8" "52.3" "49.0" "63.5" "71.3" "62.2" "56.7" "50.6" "64.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4568702403893883224" "False" "Medium" "IsMasterProtein" "O43861" "Probable phospholipid-transporting ATPase IIB OS=Homo sapiens OX=9606 GN=ATP9B PE=1 SV=4" "0.020" "False" "1.717" "1" "1" "1" "1" "1147" "129.2" "7.61" "2.66" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00702, Pf13246, Pf16209, Pf16212" "374868" "ENSG00000166377" "ATP9B" "hsa:374868; O43861; O60872; Q08AD8; Q08AD9" "Ion transport by P-type ATPases" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8754734411753965302" "False" "Medium" "IsMasterProtein" "P19823" "Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens OX=9606 GN=ITIH2 PE=1 SV=2" "0.020" "False" "1.716" "1" "1" "1" "1" "946" "106.4" "6.86" "2.40" "1" "other metabolic processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00092, Pf06668, Pf08487" "3698" "ENSG00000151655" "ITIH2" "hsa:3698; P19823; Q14659; Q15484; Q5T986" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2087285006199939008" "False" "Medium" "IsMasterProtein" "P61626" "Lysozyme C OS=Homo sapiens OX=9606 GN=LYZ PE=1 SV=1" "0.020" "False" "1.708" "6" "1" "1" "1" "148" "16.5" "9.16" "2.63" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00062" "4069" "ENSG00000090382" "LYZ" "hsa:4069; P00695; P61626; Q13170; Q9UCF8" "Neutrophil degranulation; Amyloid fiber formation; Antimicrobial peptides" "Macrophage markers; Pancreatic cancer subtypes" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5223570774126061662" "False" "Medium" "IsMasterProtein" "Q9UKA4" "A-kinase anchor protein 11 OS=Homo sapiens OX=9606 GN=AKAP11 PE=1 SV=1" "0.021" "False" "1.701" "1" "1" "1" "1" "1901" "210.4" "5.39" "1.78" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "11215" "ENSG00000023516" "AKAP11" "hsa:11215; O75124; Q9NUK7; Q9UKA4" "" "G protein signaling pathways" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1394982226643909635" "False" "Medium" "IsMasterProtein" "P10114" "Ras-related protein Rap-2a OS=Homo sapiens OX=9606 GN=RAP2A PE=1 SV=1" "0.021" "False" "1.701" "5" "1" "1" "1" "183" "20.6" "4.82" "2.17" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5911" "ENSG00000125249" "RAP2A" "B2RCJ1; hsa:5911; P10114; Q5JSC1; Q5JSC2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1297378894876740813" "False" "Medium" "IsMasterProtein" "Q16854" "Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2" "0.021" "False" "1.701" "3" "1" "1" "1" "277" "32.0" "8.66" "3.45" "1" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01712" "1716" "ENSG00000114956" "DGUOK" "hsa:1716; P78532; Q16759; Q16854; Q4ZG09; Q7L1W9; Q96BC1" "Purine salvage" "Genetic causes of porto-sinusoidal vascular disease" "2" "0" "0.921" "1.034" "0.892" "0.979" "1.134" "0.922" "0.927" "1.145" "0.676" "223.8" "206.2" "231.5" "199.5" "219.0" "253.8" "206.3" "207.5" "256.2" "151.3" "" "" "" "" "" "" "" "" "" "" "202.0" "159.1" "179.0" "134.4" "182.7" "216.6" "175.0" "150.2" "172.8" "151.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971569862806086425" "False" "Medium" "IsMasterProtein" "Q9Y2Z4" "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" "0.021" "False" "1.700" "1" "1" "1" "1" "477" "53.2" "8.98" "2.40" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00579" "51067" "ENSG00000139131" "YARS2" "D3DUW8; hsa:51067; Q9H817; Q9Y2Z4" "Mitochondrial tRNA aminoacylation" "Orexin receptor pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622690060897357887" "False" "Medium" "IsMasterProtein" "Q9UII2" "ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1" "0.021" "False" "1.698" "7" "1" "1" "1" "106" "12.2" "9.35" "3.29" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf04568" "93974" "ENSG00000130770; ENSG00000285390" "ATP5IF1" "hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2" "" "Electron transport chain: OXPHOS system in mitochondria" "1" "0" "1.094" "1.434" "1.016" "1.115" "1.318" "1.133" "1.228" "1.239" "1.068" "228.3" "249.7" "327.3" "232.0" "254.6" "300.8" "258.7" "280.3" "282.8" "243.7" "" "" "" "" "" "" "" "" "" "" "206.0" "192.6" "253.1" "156.2" "212.4" "256.8" "219.4" "202.8" "190.8" "243.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6288019369957084060" "False" "Medium" "IsMasterProtein" "Q99550" "M-phase phosphoprotein 9 OS=Homo sapiens OX=9606 GN=MPHOSPH9 PE=1 SV=7" "0.021" "False" "1.696" "1" "1" "1" "1" "1183" "132.9" "6.24" "2.54" "1" "other biological processes" "other membranes;cytoskeleton;ER/Golgi" "" "" "10198" "ENSG00000051825" "MPHOSPH9" "A0A0A0MTP3; A1L486; A6NEE2; B3KR87; hsa:10198; Q99550; Q9H976; U3KQ28" "" "" "0" "0" "0.709" "0.958" "1.142" "0.690" "0.795" "0.813" "0.889" "0.950" "0.559" "89.8" "63.7" "86.0" "102.5" "62.0" "71.3" "73.0" "79.8" "85.3" "50.2" "" "" "" "" "" "" "" "" "" "" "81.0" "49.1" "66.5" "69.1" "51.7" "60.9" "61.9" "57.7" "57.5" "50.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633988099481439098" "False" "Medium" "IsMasterProtein" "Q9Y5T5" "Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1" "0.021" "False" "1.693" "1" "1" "1" "1" "823" "93.5" "6.93" "2.48" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf00443, Pf02148" "10600" "ENSG00000156256; ENSG00000291527" "USP16" "A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9; hsa:10600; Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; Q9Y5T5" "Ub-specific processing proteases" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6440494837518419053" "False" "Medium" "IsMasterProtein" "Q9Y3B3" "Transmembrane emp24 domain-containing protein 7 OS=Homo sapiens OX=9606 GN=TMED7 PE=1 SV=2" "0.021" "False" "1.689" "3" "1" "1" "1" "224" "25.2" "6.89" "2.26" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01105" "100302736; 51014" "ENSG00000134970" "TMED7" "hsa:100302736; hsa:51014; Q8NBU8; Q8WUU6; Q96K51; Q9Y3B3" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703495334451703375" "False" "Medium" "IsMasterProtein" "O94782" "Ubiquitin carboxyl-terminal hydrolase 1 OS=Homo sapiens OX=9606 GN=USP1 PE=1 SV=1" "0.021" "False" "1.687" "1" "1" "1" "1" "785" "88.2" "5.45" "2.19" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443" "7398" "ENSG00000162607" "USP1" "A0PJ95; D3DQ57; hsa:7398; O94782; Q05BX7; Q59H66; Q9UFR0; Q9UNJ3" "Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex" "miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network" "4" "0" "0.979" "0.987" "1.395" "0.940" "0.959" "1.013" "0.840" "1.114" "1.874" "72.4" "70.9" "71.5" "101.0" "68.1" "69.4" "73.4" "60.9" "80.7" "135.7" "" "" "" "" "" "" "" "" "" "" "65.4" "54.7" "55.3" "68.0" "56.8" "59.3" "62.3" "44.0" "54.4" "135.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5797732752713602243" "False" "Medium" "IsMasterProtein" "Q15050" "Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2" "0.021" "False" "1.687" "2" "1" "1" "1" "365" "41.2" "10.70" "2.07" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf04939" "23212" "ENSG00000179041" "RRS1" "hsa:23212; Q15050; Q9BUX8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749856808040687854" "False" "Medium" "IsMasterProtein" "Q8WTS6" "Histone-lysine N-methyltransferase SETD7 OS=Homo sapiens OX=9606 GN=SETD7 PE=1 SV=1" "0.021" "False" "1.687" "2" "1" "1" "1" "366" "40.7" "4.63" "2.88" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf02493" "80854" "ENSG00000145391" "SETD7" "B5WWL3; hsa:80854; Q0VAH3; Q4W5A9; Q8WTS6; Q9C0E6" "PKMTs methylate histone lysines" "Histone modifications" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3797665255168145849" "False" "Medium" "IsMasterProtein" "P46087" "28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2" "0.021" "False" "1.686" "1" "1" "1" "1" "812" "89.2" "9.23" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf08062, Pf17125" "4839" "ENSG00000111641" "NOP2" "A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30" "rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "Imatinib and chronic myeloid leukemia" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4873150472968897924" "False" "Medium" "IsMasterProtein" "Q68DE3" "Basic helix-loop-helix domain-containing protein USF3 OS=Homo sapiens OX=9606 GN=USF3 PE=1 SV=4" "0.021" "False" "1.685" "0" "1" "2" "1" "2245" "241.5" "7.61" "5.80" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00010" "205717" "ENSG00000176542" "USF3" "hsa:205717; Q68DE3; Q7Z3L9; Q8IVF3; Q9H8T4" "" "" "0" "0" "0.916" "1.082" "0.984" "0.919" "1.126" "0.836" "0.898" "1.172" "0.860" "386.0" "353.6" "417.6" "379.9" "354.8" "434.6" "322.8" "346.8" "452.6" "332.2" "" "" "" "" "" "" "" "" "" "" "348.5" "272.8" "323.0" "255.8" "296.0" "370.9" "273.8" "251.0" "305.2" "332.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4461868117343589472" "False" "Medium" "IsMasterProtein" "Q66K14" "TBC1 domain family member 9B OS=Homo sapiens OX=9606 GN=TBC1D9B PE=1 SV=3" "0.021" "False" "1.682" "1" "1" "1" "1" "1250" "140.4" "5.25" "2.88" "1" "" "other membranes" "enzyme regulator activity;other molecular function" "Pf00566, Pf02893" "23061" "ENSG00000197226; ENSG00000284400" "TBC1D9B" "D3DWQ5; D3DWQ6; hsa:23061; O75163; Q53EY0; Q66K14; Q6MZI2; Q96H49" "" "" "0" "0" "0.980" "0.969" "1.199" "0.942" "0.983" "0.924" "0.867" "0.972" "1.430" "42.1" "41.2" "40.8" "50.4" "39.6" "41.4" "38.9" "36.5" "40.9" "60.1" "" "" "" "" "" "" "" "" "" "" "38.0" "31.8" "31.5" "34.0" "33.0" "35.3" "33.0" "26.4" "27.6" "60.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5583729165405332410" "False" "Medium" "IsMasterProtein" "Q96AB6" "Protein N-terminal asparagine amidohydrolase OS=Homo sapiens OX=9606 GN=NTAN1 PE=1 SV=3" "0.021" "False" "1.679" "2" "1" "1" "1" "310" "34.7" "6.27" "2.27" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf14736" "123803" "ENSG00000157045; ENSG00000275779" "NTAN1" "hsa:123803; Q7Z4Z0; Q96AB6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "456544607600152383" "False" "Medium" "IsMasterProtein" "Q9UJY5" "ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1" "0.021" "False" "1.676" "1" "1" "1" "1" "639" "70.3" "5.29" "2.71" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "26088" "ENSG00000100083" "GGA1" "A8K3D3; B0QYR7; hsa:26088; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; Q9UJY5" "Amyloid fiber formation; TBC/RABGAPs" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "524672605360435536" "False" "Medium" "IsMasterProtein" "O95273" "Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2" "0.021" "False" "1.676" "4" "1" "1" "1" "360" "40.2" "4.82" "1.83" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf13324, Pf20936" "23582" "ENSG00000166946" "CCNDBP1" "A8K3Q0; A8K3U2; hsa:23582; O95273; Q6ZQN9; Q7Z519; Q8NBS7; Q8NBY2; Q9NS19; Q9NYH3; Q9UHX9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6764322891151840328" "False" "Medium" "IsMasterProtein" "P19484" "Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3" "0.021" "False" "1.669" "2" "1" "1" "1" "476" "52.8" "6.29" "3.50" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7942" "ENSG00000112561" "TFEB" "hsa:7942; P19484; Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8" "" "PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Type 2 papillary renal cell carcinoma; Autophagy in pancreatic ductal adenocarcinoma" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2298234370805110889" "False" "Medium" "IsMasterProtein" "Q96DE9" "Protein EOLA2 OS=Homo sapiens OX=9606 GN=EOLA2 PE=2 SV=1" "0.021" "False" "1.665" "5" "1" "1" "1" "158" "17.8" "6.90" "2.13" "1" "" "" "" "" "541578" "ENSG00000197021" "EOLA2" "hsa:541578; Q96DE9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043642977461230788" "False" "Medium" "IsMasterProtein" "Q92575" "UBX domain-containing protein 4 OS=Homo sapiens OX=9606 GN=UBXN4 PE=1 SV=2" "0.021" "False" "1.665" "1" "1" "1" "1" "508" "56.7" "6.38" "2.84" "1" "stress response" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf00789" "23190" "ENSG00000144224" "UBXN4" "A8K9W4; hsa:23190; Q4ZG56; Q8IYM5; Q92575" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5332957940649224496" "False" "Medium" "IsMasterProtein" "Q9Y519" "Transmembrane protein 184B OS=Homo sapiens OX=9606 GN=TMEM184B PE=1 SV=2" "0.021" "False" "1.664" "2" "1" "1" "1" "407" "45.5" "6.89" "1.81" "1" "" "other membranes" "" "Pf03619" "25829" "ENSG00000198792" "TMEM184B" "A8K9D7; hsa:25829; Q63HM8; Q7Z421; Q8NBM5; Q9UGT8; Q9UGT9; Q9UGV5; Q9Y519" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2190048182398586679" "False" "Medium" "IsMasterProtein" "Q9NRX5" "Serine incorporator 1 OS=Homo sapiens OX=9606 GN=SERINC1 PE=1 SV=1" "0.022" "False" "1.659" "2" "1" "2" "1" "453" "50.5" "5.85" "4.21" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf03348" "57515" "ENSG00000111897" "SERINC1" "B3KY69; E1P565; hsa:57515; O75655; Q7Z2F5; Q8TAG1; Q9NRX5; Q9NTH8; Q9ULG7" "Serine biosynthesis" "Sphingolipid pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4718065310323386899" "False" "Medium" "IsMasterProtein" "Q5VSL9" "Striatin-interacting protein 1 OS=Homo sapiens OX=9606 GN=STRIP1 PE=1 SV=1" "0.022" "False" "1.658" "1" "1" "1" "1" "837" "95.5" "6.29" "2.25" "1" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf07923, Pf11882" "85369" "ENSG00000143093" "STRIP1" "hsa:85369; Q0V925; Q5VSL8; Q5VSL9; Q658K2; Q6ZV31; Q8N598; Q96SN2; Q9C0A2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2137226823831967498" "False" "Medium" "IsMasterProtein" "Q0VD83" "Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3" "0.022" "False" "1.657" "1" "1" "2" "1" "1097" "115.6" "4.40" "1.70" "1" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "" "55911" "ENSG00000184730" "APOBR" "H3BU97; hsa:55911; Q0VD81; Q0VD83; Q8NC15; Q9NPJ9" "VLDL clearance" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652692427915398655" "False" "Medium" "IsMasterProtein" "Q9H0H5" "Rac GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RACGAP1 PE=1 SV=1" "0.022" "False" "1.655" "1" "1" "1" "1" "632" "71.0" "8.88" "2.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00130, Pf00620" "29127" "ENSG00000161800" "RACGAP1" "hsa:29127; Q6PJ26; Q9H0H5; Q9NWN2; Q9P250; Q9P2W2" "CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic; RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; Kinesins; MHC class II antigen presentation" "S1P receptor signal transduction; Wnt signaling pathway and pluripotency" "13" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5401388015032906251" "False" "Medium" "IsMasterProtein" "O95402" "Mediator of RNA polymerase II transcription subunit 26 OS=Homo sapiens OX=9606 GN=MED26 PE=1 SV=2" "0.022" "False" "1.652" "2" "1" "1" "1" "600" "65.4" "9.16" "2.64" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08711, Pf15693, Pf15694" "9441" "ENSG00000105085" "MED26" "A1A4S3; hsa:9441; O95402; Q0VGB6" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "" "4" "0" "1.175" "1.097" "1.016" "1.072" "1.250" "0.826" "0.954" "1.419" "1.020" "52.0" "61.1" "57.1" "52.9" "55.8" "65.0" "43.0" "49.6" "73.8" "53.1" "" "" "" "" "" "" "" "" "" "" "46.9" "47.1" "44.1" "35.6" "46.5" "55.5" "36.5" "35.9" "49.8" "53.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3445317151605985554" "False" "Medium" "IsMasterProtein" "Q13356" "RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1" "0.022" "False" "1.646" "4" "1" "1" "1" "520" "58.8" "8.78" "0.00" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "23759" "ENSG00000100023" "PPIL2" "Q13356; Q13357; Q8TAH2; Q9BWR8" "mRNA Splicing - Major Pathway; Basigin interactions" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "7398915680383575894" "False" "Medium" "IsMasterProtein" "Q5BKX5" "Actin maturation protease OS=Homo sapiens OX=9606 GN=ACTMAP PE=1 SV=2" "0.022" "False" "1.646" "3" "1" "1" "1" "351" "37.8" "7.47" "2.24" "1" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf21646" "284325" "ENSG00000188493" "ACTMAP" "A8MSZ5; B4DNU7; hsa:284325; Q5BKX5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4794546056511531982" "False" "Medium" "IsMasterProtein" "Q969Q5" "Ras-related protein Rab-24 OS=Homo sapiens OX=9606 GN=RAB24 PE=1 SV=1" "0.022" "False" "1.645" "8" "1" "1" "1" "203" "23.1" "6.23" "0.00" "1" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53917" "ENSG00000169228" "RAB24" "A0A024R7N9; hsa:53917; Q7Z4Z7; Q969Q5" "Neutrophil degranulation; RAB geranylgeranylation" "5q35 copy number variation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1533138465656150959" "False" "Medium" "IsMasterProtein" "Q5VWQ0" "Lysine-specific demethylase 9 OS=Homo sapiens OX=9606 GN=RSBN1 PE=1 SV=2" "0.022" "False" "1.645" "1" "1" "1" "1" "802" "90.0" "8.60" "2.72" "1" "cell organization and biogenesis" "nucleus" "other molecular function" "" "54665" "ENSG00000081019" "RSBN1" "A8K937; hsa:54665; Q5VWQ0; Q6AI21; Q8TC33; Q9HA80; Q9NUP6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2963381124708492524" "False" "Medium" "IsMasterProtein" "Q5JTH9" "RRP12-like protein OS=Homo sapiens OX=9606 GN=RRP12 PE=1 SV=2" "0.022" "False" "1.645" "1" "1" "1" "1" "1297" "143.6" "8.75" "2.83" "1" "RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf08161" "23223" "ENSG00000052749" "RRP12" "B4DK00; E9PCK7; hsa:23223; Q5JTH8; Q5JTH9; Q69YK4; Q96E87; Q9BUH3; Q9Y4C7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7979244283854796707" "False" "Medium" "IsMasterProtein" "Q96S90" "LysM and putative peptidoglycan-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LYSMD1 PE=1 SV=1" "0.022" "False" "1.645" "5" "1" "1" "1" "227" "25.0" "8.57" "1.74" "1" "" "nucleus" "" "Pf01476" "388695" "ENSG00000163155" "LYSMD1" "B4DQA1; hsa:388695; Q69YX9; Q96S90" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "578251195168397790" "False" "Medium" "IsMasterProtein" "Q8TDX5" "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase OS=Homo sapiens OX=9606 GN=ACMSD PE=1 SV=1" "0.022" "False" "1.642" "2" "1" "1" "1" "336" "38.0" "6.99" "2.35" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf04909" "130013" "ENSG00000153086" "ACMSD" "hsa:130013; Q3B7X3; Q53SR5; Q8TDX5; Q96KY2" "Tryptophan catabolism" "NAD+ biosynthetic pathways; Tryptophan metabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752012878185974074" "False" "Medium" "IsMasterProtein" "P49441" "Inositol polyphosphate 1-phosphatase OS=Homo sapiens OX=9606 GN=INPP1 PE=1 SV=1" "0.022" "False" "1.639" "2" "1" "1" "1" "399" "44.0" "5.26" "2.64" "1" "other metabolic processes;signal transduction" "cytosol" "other molecular function" "Pf00459" "3628" "ENSG00000151689" "INPP1" "hsa:3628; P49441" "Synthesis of IP2, IP, and Ins in the cytosol" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5463770494626313283" "False" "Medium" "IsMasterProtein" "Q9C035" "Tripartite motif-containing protein 5 OS=Homo sapiens OX=9606 GN=TRIM5 PE=1 SV=1" "0.022" "False" "1.635" "2" "1" "1" "1" "493" "56.3" "6.05" "0.00" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "85363" "ENSG00000132256" "TRIM5" "A6NGQ1; A8WFA8; D3DQS8; D3DQS9; G3GJY1; hsa:85363; Q2MLV4; Q2MLV8; Q2MLV9; Q2MLW1; Q2MLW3; Q2MLW4; Q2MLW6; Q2MLW7; Q2MLX1; Q2MLX2; Q2MLX3; Q2MLX5; Q2MLY3; Q2MLY4; Q2V6Q6; Q6GX26; Q8WU46; Q96SR5; Q9C031; Q9C032; Q9C033; Q9C034; Q9C035" "Interferon gamma signaling" "Mesodermal commitment pathway" "2" "0" "0.928" "0.916" "1.175" "1.058" "0.799" "0.797" "0.832" "0.773" "2.705" "26.0" "24.1" "23.8" "30.5" "27.5" "20.8" "20.7" "21.6" "20.1" "70.3" "" "" "" "" "" "" "" "" "" "" "23.4" "18.6" "18.4" "20.6" "22.9" "17.7" "17.6" "15.6" "13.5" "70.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8604308957137322217" "False" "Medium" "IsMasterProtein" "Q8IXQ5" "Kelch-like protein 7 OS=Homo sapiens OX=9606 GN=KLHL7 PE=1 SV=2" "0.023" "False" "1.618" "2" "1" "1" "1" "586" "65.9" "6.48" "2.93" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "55975" "ENSG00000122550" "KLHL7" "A4D144; B7Z5I9; G5E9G3; hsa:55975; Q7Z765; Q8IXQ5; Q96MV2; Q9BQF8; Q9UDQ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7500020878555026308" "False" "Medium" "IsMasterProtein" "Q9BZE4" "GTP-binding protein 4 OS=Homo sapiens OX=9606 GN=GTPBP4 PE=1 SV=3" "0.023" "False" "1.618" "2" "1" "1" "1" "634" "73.9" "9.50" "2.75" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf06858, Pf08155, Pf17835" "23560" "ENSG00000107937" "GTPBP4" "B3KMC5; B4DY13; B7Z7A3; hsa:23560; O95446; Q5T3R8; Q9BZE4; Q9NVJ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1043933861816378704" "False" "Medium" "IsMasterProtein" "O60303" "Katanin-interacting protein OS=Homo sapiens OX=9606 GN=KATNIP PE=1 SV=4" "0.023" "False" "1.617" "1" "1" "2" "1" "1618" "180.8" "5.87" "0.00" "1" "transport" "cytoskeleton;other cell component" "" "Pf14652" "23247" "ENSG00000047578" "KATNIP" "A7E2C2; hsa:23247; O60303" "" "Ciliopathies" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2636434062481616227" "False" "Medium" "IsMasterProtein" "P42858" "Huntingtin OS=Homo sapiens OX=9606 GN=HTT PE=1 SV=2" "0.023" "False" "1.616" "0" "1" "1" "1" "3142" "347.4" "6.20" "2.52" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf20925, Pf20926, Pf20927" "3064" "ENSG00000197386" "HTT" "hsa:3064; P42858; Q9UQB7" "Regulation of MECP2 expression and activity" "Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome; 15q25 copy number variation; HDAC6 interactions in the central nervous system" "7" "0" "0.908" "0.855" "0.939" "0.973" "0.846" "0.966" "0.665" "0.904" "3.848" "89.5" "81.2" "76.5" "84.0" "87.0" "75.7" "86.4" "59.5" "80.9" "344.2" "" "" "" "" "" "" "" "" "" "" "80.8" "62.7" "59.1" "56.6" "72.6" "64.6" "73.3" "43.1" "54.6" "344.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564973388906415615" "False" "Medium" "IsMasterProtein" "Q96DY7" "Mdm2-binding protein OS=Homo sapiens OX=9606 GN=MTBP PE=1 SV=1" "0.023" "False" "1.613" "1" "1" "1" "1" "904" "102.1" "7.77" "2.12" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf14918, Pf14919, Pf14920" "27085" "ENSG00000172167" "MTBP" "B4DUR5; hsa:27085; Q96DY7; Q9HA89" "" "" "0" "0" "1.150" "1.153" "0.955" "1.046" "1.195" "1.119" "0.965" "1.033" "0.887" "79.6" "91.6" "91.8" "76.0" "83.3" "95.2" "89.1" "76.8" "82.3" "70.6" "" "" "" "" "" "" "" "" "" "" "71.9" "70.6" "71.0" "51.2" "69.5" "81.2" "75.6" "55.6" "55.5" "70.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782188447227820628" "False" "Medium" "IsMasterProtein" "Q17RB0" "Retrotransposon Gag-like protein 8B OS=Homo sapiens OX=9606 GN=RTL8B PE=1 SV=1" "0.023" "False" "1.612" "13" "1" "1" "1" "113" "13.2" "5.27" "0.00" "1" "" "" "" "Pf16297" "441518" "ENSG00000212747" "RTL8B" "hsa:441518; Q17RB0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "High" "1" "" "-6300831258650065566" "False" "Medium" "IsMasterProtein" "Q9P281" "BAH and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BAHCC1 PE=1 SV=4" "0.023" "False" "1.610" "0" "1" "2" "1" "2639" "279.8" "8.78" "5.88" "1" "" "" "other molecular function" "Pf01426, Pf21744" "57597" "ENSG00000266074" "BAHCC1" "A0A075B747; hsa:57597; Q5U629; Q9P281" "" "" "0" "0" "1.219" "1.182" "1.184" "1.132" "1.259" "0.977" "1.035" "1.317" "0.953" "109.0" "132.8" "128.8" "129.0" "123.4" "137.2" "106.4" "112.8" "143.5" "103.8" "" "" "" "" "" "" "" "" "" "" "98.4" "102.5" "99.6" "86.9" "102.9" "117.1" "90.3" "81.6" "96.8" "103.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314787517679089989" "False" "Medium" "IsMasterProtein" "Q8WUX9" "Charged multivesicular body protein 7 OS=Homo sapiens OX=9606 GN=CHMP7 PE=1 SV=1" "0.023" "False" "1.605" "2" "1" "1" "1" "453" "50.9" "5.35" "3.11" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "91782" "ENSG00000147457" "CHMP7" "B2RDT3; B4DKJ6; D3DSS1; hsa:91782; Q8NDM1; Q8WUX9; Q9BT50" "Late endosomal microautophagy; Macroautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-210569023749279335" "False" "Medium" "IsMasterProtein" "Q01484" "Ankyrin-2 OS=Homo sapiens OX=9606 GN=ANK2 PE=1 SV=4" "0.023" "False" "1.605" "0" "1" "1" "1" "3957" "433.4" "5.14" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00023, Pf00531, Pf00791, Pf17809" "287" "ENSG00000145362" "ANK2" "hsa:287; Q01484; Q01485; Q08AC7; Q08AC8; Q7Z3L5" "COPI-mediated anterograde transport; Interaction between L1 and Ankyrins" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286277691384661774" "False" "Medium" "IsMasterProtein" "Q6P1X5" "Transcription initiation factor TFIID subunit 2 OS=Homo sapiens OX=9606 GN=TAF2 PE=1 SV=3" "0.023" "False" "1.604" "1" "1" "1" "1" "1199" "136.9" "8.19" "2.56" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "6873" "ENSG00000064313" "TAF2" "B2RE82; hsa:6873; O43487; O43604; O60668; Q6P1X5; Q86WW7; Q8IWK4" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "9" "0" "1.022" "1.028" "0.950" "1.031" "0.880" "1.006" "0.981" "0.952" "1.419" "35.6" "36.4" "36.6" "33.9" "36.7" "31.4" "35.8" "34.9" "33.9" "50.5" "" "" "" "" "" "" "" "" "" "" "32.2" "28.1" "28.3" "22.8" "30.6" "26.8" "30.4" "25.3" "22.9" "50.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801357975470055423" "False" "Medium" "IsMasterProtein" "O14526" "F-BAR domain only protein 1 OS=Homo sapiens OX=9606 GN=FCHO1 PE=1 SV=2" "0.023" "False" "1.603" "1" "1" "1" "1" "889" "96.8" "6.96" "2.36" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00611, Pf10291" "23149" "ENSG00000130475" "FCHO1" "A6NHE6; A8K5U5; B4E120; hsa:23149; O14526; Q05C93; Q8IW22" "Cargo recognition for clathrin-mediated endocytosis" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3499966319797164374" "False" "Medium" "IsMasterProtein" "Q9UKZ1" "CCR4-NOT transcription complex subunit 11 OS=Homo sapiens OX=9606 GN=CNOT11 PE=1 SV=1" "0.023" "False" "1.602" "2" "1" "1" "1" "510" "55.2" "6.40" "1.84" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10155" "55571" "ENSG00000158435" "CNOT11" "hsa:55571; Q6P2M9; Q8N681; Q9UKZ1" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "" "3" "0" "0.962" "0.902" "1.098" "0.996" "0.835" "1.074" "0.655" "0.953" "1.239" "25.4" "24.5" "22.9" "27.9" "25.3" "21.2" "27.3" "16.6" "24.2" "31.5" "" "" "" "" "" "" "" "" "" "" "23.0" "18.9" "17.7" "18.8" "21.1" "18.1" "23.2" "12.0" "16.3" "31.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580971408817382446" "False" "Medium" "IsMasterProtein" "O75956" "Cyclin-dependent kinase 2-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK2AP2 PE=1 SV=1" "0.023" "False" "1.600" "6" "1" "2" "1" "126" "13.1" "9.48" "5.04" "1" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf09806" "10263" "ENSG00000167797" "CDK2AP2" "hsa:10263; O75956" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1079970231348411626" "False" "Medium" "IsMasterProtein" "P02452" "Collagen alpha-1(I) chain OS=Homo sapiens OX=9606 GN=COL1A1 PE=1 SV=6" "0.023" "True" "1.598" "1" "1" "1" "1" "1464" "138.8" "5.80" "2.82" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "other molecular function" "Pf00093, Pf01391, Pf01410" "1277" "ENSG00000108821" "COL1A1" "hsa:1277; O76045; P02452; P78441; Q13896; Q13902; Q13903; Q14037; Q14992; Q15176; Q15201; Q16050; Q59F64; Q7KZ30; Q7KZ34; Q8IVI5; Q8N473; Q9UML6; Q9UMM7" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Collagen degradation; Integrin cell surface interactions; ECM proteoglycans; Collagen chain trimerization; GPVI-mediated activation cascade; Syndecan interactions; MET activates PTK2 signaling; RUNX2 regulates osteoblast differentiation; Anchoring fibril formation; Crosslinking of collagen fibrils; Platelet Adhesion to exposed collagen; Platelet Aggregation (Plug Formation); Scavenging by Class A Receptors; GP1b-IX-V activation signalling; Enhanced cleavage of VWF variant by ADAMTS13; Enhanced binding of GP1BA variant to VWF multimer:collagen ; Defective VWF cleavage by ADAMTS13 variant; Defective VWF binding to collagen type I ; Defective binding of VWF variant to GPIb:IX:V" "Focal adhesion; Osteoblast signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-509-3p alteration of YAP1/ECM axis; PI3K-Akt signaling pathway; Inflammatory response pathway; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta; Angiotensin II receptor type 1 pathway; Burn wound healing; CCL18 signaling pathway; NRP1-triggered signaling pathways in pancreatic cancer ; Urotensin-II-mediated signaling pathway; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway" "41" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6886594892760411930" "False" "Medium" "IsMasterProtein" "Q13946" "High affinity 3',5'-cyclic-AMP phosphodiesterase 7A OS=Homo sapiens OX=9606 GN=PDE7A PE=1 SV=2" "0.024" "False" "1.589" "1" "1" "1" "1" "482" "55.5" "7.50" "2.98" "1" "other metabolic processes;signal transduction" "cytosol" "other molecular function" "Pf00233" "5150" "ENSG00000205268" "PDE7A" "A0AVH6; A8K436; A8K9G5; hsa:5150; O15380; Q13946; Q96T72" "G alpha (s) signalling events" "Ectoderm differentiation; Ectoderm differentiation; G protein signaling pathways; Phosphodiesterases in neuronal function" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5967874803311728941" "False" "Medium" "IsMasterProtein" "Q9UBP0" "Spastin OS=Homo sapiens OX=9606 GN=SPAST PE=1 SV=1" "0.024" "False" "1.588" "1" "1" "1" "1" "616" "67.2" "9.64" "3.06" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862" "6683" "ENSG00000021574" "SPAST" "A7E2A7; hsa:6683; Q9UBP0; Q9UPR9" "Sealing of the nuclear envelope (NE) by ESCRT-III" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1698124095596496194" "False" "Medium" "IsMasterProtein" "Q14147" "Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens OX=9606 GN=DHX34 PE=1 SV=2" "0.025" "False" "1.585" "1" "1" "1" "1" "1143" "128.0" "7.56" "1.95" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9704" "ENSG00000134815" "DHX34" "B4DMY8; hsa:9704; Q14147" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120565565592818035" "False" "Medium" "IsMasterProtein" "P23443" "Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2" "0.025" "False" "1.585" "2" "1" "2" "1" "525" "59.1" "6.65" "2.50" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6198" "ENSG00000108443" "RPS6KB1" "B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1; hsa:6198; P23443; Q7Z721" "mTORC1-mediated signalling" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Kit receptor signaling pathway; IL6 signaling pathway; BDNF-TrkB signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway" "42" "0" "0.892" "0.767" "1.061" "1.089" "0.841" "1.115" "0.933" "0.832" "0.797" "42.2" "37.6" "32.3" "44.7" "45.9" "35.5" "47.0" "39.4" "35.1" "33.6" "" "" "" "" "" "" "" "" "" "" "38.1" "29.0" "25.0" "30.1" "38.3" "30.3" "39.9" "28.5" "23.7" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8244931832406879896" "False" "Medium" "IsMasterProtein" "P78424" "POU domain, class 6, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU6F2 PE=1 SV=3" "0.025" "False" "1.584" "1" "1" "5" "1" "691" "73.2" "7.77" "12.66" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "11281" "ENSG00000106536" "POU6F2" "A4D1W2; C4AMB9; hsa:11281; P78424; P78425; Q75ME8; Q86UM6; Q9UDS7" "" "" "0" "0" "0.887" "0.966" "1.068" "0.940" "0.831" "1.012" "0.971" "0.949" "0.790" "522.7" "463.4" "505.2" "558.1" "491.2" "434.2" "528.8" "507.6" "495.9" "412.8" "" "" "" "" "" "" "" "" "" "" "471.8" "357.4" "390.7" "375.8" "409.7" "370.6" "448.6" "367.4" "334.5" "412.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660513057168003161" "False" "Medium" "IsMasterProtein" "Q99805" "Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1" "0.025" "False" "1.583" "1" "1" "2" "1" "663" "75.7" "7.44" "5.58" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9375" "ENSG00000125304" "TM9SF2" "A8K399; hsa:9375; Q2TAY5; Q99805" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1252831994268086785" "False" "Medium" "IsMasterProtein" "O00268" "Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2" "0.025" "False" "1.580" "1" "1" "1" "1" "1085" "110.0" "9.94" "3.36" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6874" "ENSG00000130699" "TAF4" "A6NGD9; hsa:6874; O00268; Q5TBP6; Q99721; Q9BR40; Q9BX42" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9045329245485250049" "False" "Medium" "IsMasterProtein" "Q9BW66" "Cyclin-dependent kinase 2-interacting protein OS=Homo sapiens OX=9606 GN=CINP PE=1 SV=1" "0.025" "False" "1.579" "4" "1" "1" "1" "212" "24.3" "6.28" "2.78" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "" "51550" "ENSG00000100865" "CINP" "F5H7P3; F5H8A7; hsa:51550; Q9BW66; Q9NPF9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1911741891991956456" "False" "Medium" "IsMasterProtein" "Q9NX14" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB11 PE=1 SV=1" "0.025" "False" "1.575" "5" "1" "1" "1" "153" "17.3" "5.22" "2.07" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion" "" "Pf10183" "54539" "ENSG00000147123" "NDUFB11" "hsa:54539; Q5JRR3; Q5JRR4; Q6IAB6; Q8WZ96; Q9BXX9; Q9NX14" "Complex I biogenesis" "Nonalcoholic fatty liver disease" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3478129203947577365" "False" "Medium" "IsMasterProtein" "Q93075" "Putative deoxyribonuclease TATDN2 OS=Homo sapiens OX=9606 GN=TATDN2 PE=1 SV=2" "0.025" "False" "1.570" "1" "1" "2" "1" "761" "85.0" "7.39" "2.36" "1" "" "nucleus" "other molecular function" "Pf01026" "9797" "ENSG00000157014" "TATDN2" "hsa:9797; Q3MIL9; Q5BKU0; Q93075" "XBP1(S) activates chaperone genes" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6079513439335487390" "False" "Medium" "IsMasterProtein" "Q9UGV2" "Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2" "0.025" "False" "1.570" "2" "1" "2" "1" "375" "41.4" "5.31" "1.74" "1" "signal transduction;other biological processes" "other cell component" "" "Pf03096" "57446" "ENSG00000101079" "NDRG3" "A2A2S8; E1P5U7; E1P5U8; hsa:57446; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7; Q9H411; Q9H8J6; Q9UGV2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2208639490373230766" "False" "Medium" "IsMasterProtein" "Q92882" "Osteoclast-stimulating factor 1 OS=Homo sapiens OX=9606 GN=OSTF1 PE=1 SV=2" "0.025" "False" "1.569" "3" "1" "1" "1" "214" "23.8" "5.68" "2.32" "1" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00018, Pf12796" "26578" "ENSG00000134996" "OSTF1" "hsa:26578; Q5W126; Q92882; Q96IJ4" "Neutrophil degranulation" "" "1" "0" "0.945" "0.760" "1.036" "0.954" "0.824" "0.947" "0.748" "0.933" "2.129" "86.7" "82.0" "65.9" "89.8" "82.7" "71.5" "82.1" "64.9" "80.9" "184.6" "" "" "" "" "" "" "" "" "" "" "78.3" "63.2" "50.9" "60.5" "69.0" "61.0" "69.7" "46.9" "54.6" "184.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225862634974144158" "False" "Medium" "IsMasterProtein" "Q8N392" "Rho GTPase-activating protein 18 OS=Homo sapiens OX=9606 GN=ARHGAP18 PE=1 SV=3" "0.025" "False" "1.566" "2" "1" "1" "1" "663" "74.9" "6.44" "2.19" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "93663" "ENSG00000146376" "ARHGAP18" "E1P575; hsa:93663; Q58EZ3; Q6P679; Q6PJD7; Q8N392; Q96S64" "RHOC GTPase cycle; RHOA GTPase cycle" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5262953241339830264" "False" "Medium" "IsMasterProtein" "Q8WUH6" "Transmembrane protein 263 OS=Homo sapiens OX=9606 GN=TMEM263 PE=1 SV=1" "0.025" "False" "1.566" "10" "1" "1" "1" "116" "11.7" "9.32" "0.00" "1" "" "other membranes" "" "Pf15475" "90488" "ENSG00000151135" "TMEM263" "B3KMN9; hsa:90488; Q8WUH6" "" "" "0" "0" "1.071" "1.153" "0.943" "1.077" "0.897" "0.896" "1.015" "1.092" "1.114" "18.4" "19.7" "21.2" "17.3" "19.8" "16.5" "16.5" "18.6" "20.0" "20.5" "" "" "" "" "" "" "" "" "" "" "16.6" "15.2" "16.4" "11.7" "16.5" "14.1" "14.0" "13.5" "13.5" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7932092047749644365" "False" "Medium" "IsMasterProtein" "Q15831" "Serine/threonine-protein kinase STK11 OS=Homo sapiens OX=9606 GN=STK11 PE=1 SV=1" "0.026" "False" "1.563" "3" "1" "1" "1" "433" "48.6" "7.43" "2.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "6794" "ENSG00000118046" "STK11" "B2RBX7; E7EW76; hsa:6794; Q15831" "Regulation of TP53 Activity through Phosphorylation; Energy dependent regulation of mTOR by LKB1-AMPK; FOXO-mediated transcription of cell death genes; AMPK inhibits chREBP transcriptional activation activity" "AMP-activated protein kinase signaling; Polycystic kidney disease pathway; mir-124 predicted interactions with cell cycle and differentiation ; ATM signaling in development and disease ; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Female steroid hormones in cardiomyocyte energy metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3093573351125982310" "False" "Medium" "IsMasterProtein" "Q86WJ1" "Chromodomain-helicase-DNA-binding protein 1-like OS=Homo sapiens OX=9606 GN=CHD1L PE=1 SV=3" "0.026" "False" "1.561" "1" "1" "1" "1" "897" "100.9" "6.90" "2.61" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00176, Pf00271" "9557" "ENSG00000131778" "CHD1L" "A5YM64; B4DDE1; B5MDZ7; Q53EZ3; Q5VXX7; Q6DD94; Q6PK83; Q86WJ1; Q86XH3; Q96HF7; Q96SP3; Q9BVJ1; Q9NVV8" "Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "1q21.1 copy number variation syndrome; Nucleotide excision repair in xeroderma pigmentosum" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779285951144314922" "False" "Medium" "IsMasterProtein" "Q8IUH3" "RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1" "0.026" "False" "1.560" "2" "1" "1" "1" "476" "53.5" "7.17" "2.17" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "129831" "ENSG00000155636" "RBM45" "hsa:129831; Q6NYL0; Q8IUH3; Q8NFC9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1730131359197889533" "False" "Medium" "IsMasterProtein" "Q8IVU3" "Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2" "0.026" "False" "1.559" "1" "1" "1" "1" "1022" "115.1" "7.96" "2.45" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632, Pf13540" "55008" "ENSG00000138642" "HERC6" "B4DIY5; hsa:55008; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8IVU3; Q8NAN3; Q9NWS4" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.120" "1.109" "0.955" "1.092" "0.862" "0.985" "1.012" "1.112" "0.863" "100.8" "112.9" "111.8" "96.3" "110.1" "86.9" "99.3" "102.0" "112.1" "87.0" "" "" "" "" "" "" "" "" "" "" "91.0" "87.1" "86.5" "64.9" "91.8" "74.2" "84.2" "73.8" "75.6" "87.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6224578452559730793" "False" "Medium" "IsMasterProtein" "Q9H116" "GDNF-inducible zinc finger protein 1 OS=Homo sapiens OX=9606 GN=GZF1 PE=1 SV=1" "0.026" "False" "1.557" "1" "1" "1" "1" "711" "80.4" "7.87" "1.96" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf13912" "64412" "ENSG00000125812" "GZF1" "A8K199; B2RBC3; B3KPL4; B4DF58; D3DW39; hsa:64412; Q54A22; Q96N08; Q9BQK9; Q9H116; Q9H117; Q9H6W6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2514407203909916173" "False" "Medium" "IsMasterProtein" "O95363" "Phenylalanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=FARS2 PE=1 SV=1" "0.026" "False" "1.556" "2" "1" "1" "1" "451" "52.3" "7.46" "2.60" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf03147" "10667" "ENSG00000145982" "FARS2" "B2R664; hsa:10667; O95363; Q53F66; Q5TCS3; Q6FG29; Q9NPY7; Q9P062" "Mitochondrial tRNA aminoacylation" "" "1" "0" "1.149" "1.283" "1.373" "1.504" "1.514" "1.332" "0.921" "1.424" "2.585" "38.4" "44.1" "49.2" "52.7" "57.7" "58.1" "51.1" "35.3" "54.6" "99.2" "" "" "" "" "" "" "" "" "" "" "34.6" "34.0" "38.1" "35.5" "48.1" "49.6" "43.4" "25.6" "36.9" "99.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172225001989641453" "False" "Medium" "IsMasterProtein" "Q9UNW1" "Multiple inositol polyphosphate phosphatase 1 OS=Homo sapiens OX=9606 GN=MINPP1 PE=1 SV=1" "0.026" "False" "1.552" "1" "1" "1" "1" "487" "55.0" "7.81" "2.19" "1" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00328" "9562" "ENSG00000107789" "MINPP1" "F5H683; hsa:9562; O95172; O95286; Q59EJ2; Q9UGA3; Q9UNW1" "Synthesis of IPs in the ER lumen" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2689761144797840992" "False" "Medium" "IsMasterProtein" "Q5T8A7" "Protein phosphatase 1 regulatory subunit 26 OS=Homo sapiens OX=9606 GN=PPP1R26 PE=1 SV=1" "0.026" "False" "1.552" "0" "1" "5" "1" "1209" "127.3" "8.59" "9.79" "1" "" "nucleus" "enzyme regulator activity" "Pf15740" "9858" "ENSG00000196422" "PPP1R26" "hsa:9858; Q5T8A7; Q86WU0; Q8WVV0; Q9Y4D3" "" "" "0" "0" "0.833" "0.985" "1.031" "0.766" "0.888" "0.850" "0.880" "1.045" "0.632" "266.2" "221.7" "262.2" "274.4" "203.9" "236.4" "226.2" "234.2" "278.2" "168.3" "" "" "" "" "" "" "" "" "" "" "240.3" "171.0" "202.8" "184.7" "170.1" "201.8" "191.9" "169.5" "187.6" "168.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5480517122965498200" "False" "Medium" "IsMasterProtein" "P15735" "Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Homo sapiens OX=9606 GN=PHKG2 PE=1 SV=1" "0.026" "False" "1.544" "2" "1" "1" "1" "406" "46.4" "6.38" "1.93" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069" "5261" "ENSG00000156873" "PHKG2" "A8K0C7; B4DEB7; E9PEU3; hsa:5261; P11800; P15735" "Glycogen breakdown (glycogenolysis)" "Ferroptosis; Glycogen synthesis and degradation; 1p36 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406429710445880592" "False" "Medium" "IsMasterProtein" "Q14511" "Enhancer of filamentation 1 OS=Homo sapiens OX=9606 GN=NEDD9 PE=1 SV=1" "0.026" "False" "1.542" "2" "1" "1" "1" "834" "92.8" "6.70" "0.00" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08824, Pf12026, Pf14604" "4739" "ENSG00000111859" "NEDD9" "A8K9G7; A8MSJ9; G5E9Y9; hsa:4739; Q14511; Q5T9R4; Q5XKI0" "" "TGF-beta signaling pathway; HDAC6 interactions in the central nervous system" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790868284272412731" "False" "Medium" "IsMasterProtein" "Q9UDY8" "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 OS=Homo sapiens OX=9606 GN=MALT1 PE=1 SV=1" "0.026" "False" "1.540" "2" "1" "1" "1" "824" "92.2" "5.73" "2.47" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656, Pf13895, Pf13927, Pf18703" "10892" "ENSG00000172175" "MALT1" "hsa:10892; Q9NTB7; Q9UDY8; Q9ULX4" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A/inflammasome pathway" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 22q11.2 copy number variation syndrome; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "10" "0" "1.398" "1.126" "1.582" "0.827" "0.767" "1.138" "1.135" "0.886" "0.954" "18.7" "26.2" "21.1" "29.6" "15.5" "14.4" "21.3" "21.2" "16.6" "17.9" "" "" "" "" "" "" "" "" "" "" "16.9" "20.2" "16.3" "19.9" "12.9" "12.2" "18.1" "15.4" "11.2" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1448578471139674410" "False" "Medium" "IsMasterProtein" "Q6PJ69" "E3 ubiquitin-protein ligase TRIM65 OS=Homo sapiens OX=9606 GN=TRIM65 PE=1 SV=3" "0.026" "False" "1.536" "2" "1" "1" "1" "517" "57.3" "6.70" "1.65" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf00622, Pf00643" "201292" "ENSG00000141569" "TRIM65" "hsa:201292; Q4G0F0; Q6DKJ6; Q6PJ69; Q9BRP6" "" "" "0" "0" "0.859" "0.992" "1.015" "1.170" "1.138" "1.083" "1.134" "1.225" "3.237" "30.1" "25.9" "29.9" "30.6" "35.2" "34.3" "32.6" "34.1" "36.9" "97.5" "" "" "" "" "" "" "" "" "" "" "27.2" "20.0" "23.1" "20.6" "29.4" "29.2" "27.7" "24.7" "24.9" "97.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7274845657669851" "False" "Medium" "IsMasterProtein" "Q9BQE6" "LBH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LBHD1 PE=1 SV=3" "0.026" "False" "1.533" "4" "1" "1" "1" "289" "31.5" "4.60" "2.57" "1" "other biological processes" "nucleus" "" "Pf15317" "79081" "ENSG00000162194" "LBHD1" "hsa:79081; Q96NA4; Q9BQE6" "" "" "0" "0" "0.997" "1.257" "0.982" "0.891" "1.259" "0.972" "0.859" "1.219" "1.179" "58.9" "58.7" "74.0" "57.8" "52.4" "74.1" "57.2" "50.6" "71.7" "69.4" "" "" "" "" "" "" "" "" "" "" "53.1" "45.3" "57.2" "38.9" "43.7" "63.3" "48.5" "36.6" "48.4" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260092317082084293" "False" "Medium" "IsMasterProtein" "Q13362" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP2R5C PE=1 SV=3" "0.026" "False" "1.531" "2" "1" "1" "1" "524" "61.0" "6.87" "0.00" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5527" "ENSG00000078304" "PPP2R5C" "B4DYJ8; B5BUA5; F5GWP3; hsa:5527; Q13362; Q14391; Q15060; Q15174; Q6ZN33" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "29" "0" "0.888" "0.902" "1.189" "0.991" "1.012" "0.911" "1.094" "1.064" "0.715" "57.3" "50.9" "51.7" "68.2" "56.8" "58.1" "52.2" "62.8" "61.0" "41.0" "" "" "" "" "" "" "" "" "" "" "51.8" "39.3" "40.0" "45.9" "47.4" "49.5" "44.3" "45.4" "41.2" "41.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2010666374773995606" "False" "Medium" "IsMasterProtein" "Q06587" "E3 ubiquitin-protein ligase RING1 OS=Homo sapiens OX=9606 GN=RING1 PE=1 SV=2" "0.026" "False" "1.527" "2" "1" "1" "1" "406" "42.4" "5.62" "2.41" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00097, Pf16207" "6015" "ENSG00000204227; ENSG00000206287; ENSG00000226788; ENSG00000228520; ENSG00000231115; ENSG00000235107" "RING1" "A8JZZ0; Q06587; Q5JP96; Q5SQW2; Q86V19" "Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "Pleural mesothelioma; Notch signaling pathway" "11" "0" "0.918" "0.916" "1.075" "1.152" "0.898" "0.961" "0.653" "0.984" "5.841" "42.2" "38.7" "38.6" "45.3" "48.6" "37.9" "40.5" "27.5" "41.5" "246.3" "" "" "" "" "" "" "" "" "" "" "38.1" "29.8" "29.9" "30.5" "40.5" "32.3" "34.4" "19.9" "28.0" "246.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3614438977501336635" "False" "Medium" "IsMasterProtein" "Q92558" "Actin-binding protein WASF1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "0.026" "False" "1.525" "1" "1" "1" "1" "559" "61.6" "6.46" "2.17" "1" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5420555494446778238" "False" "Medium" "IsMasterProtein" "P15907" "Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Homo sapiens OX=9606 GN=ST6GAL1 PE=1 SV=1" "0.026" "False" "1.523" "2" "1" "1" "1" "406" "46.6" "9.01" "2.22" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "other molecular function" "Pf00777" "6480" "ENSG00000073849" "ST6GAL1" "A8KA14; B2R513; D3DNV3; hsa:6480; P15907" "Sialic acid metabolism; N-Glycan antennae elongation; Maturation of spike protein; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis" "N-glycan biosynthesis" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4276327742936350895" "False" "Medium" "IsMasterProtein" "Q9H582" "Zinc finger protein 644 OS=Homo sapiens OX=9606 GN=ZNF644 PE=1 SV=2" "0.026" "False" "1.522" "1" "1" "1" "1" "1327" "149.5" "8.16" "2.54" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "84146" "ENSG00000122482" "ZNF644" "A2RU71; hsa:84146; Q2TAM0; Q5TCC0; Q6BEP7; Q6P446; Q6PI06; Q7LG67; Q9H582; Q9ULJ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7006470883550975428" "False" "Medium" "IsMasterProtein" "Q6B0I6" "Lysine-specific demethylase 4D OS=Homo sapiens OX=9606 GN=KDM4D PE=1 SV=3" "0.026" "False" "1.515" "2" "1" "1" "1" "523" "58.6" "9.16" "2.34" "1" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373, Pf02375" "55693" "ENSG00000186280" "KDM4D" "B3KPC4; hsa:55693; Q0VF39; Q6B0I6; Q9NT41; Q9NW76" "HDMs demethylate histones" "10q11.21q11.23 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4052352701498406510" "False" "Medium" "IsMasterProtein" "Q9Y6J9" "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens OX=9606 GN=TAF6L PE=1 SV=1" "0.026" "False" "1.513" "1" "1" "1" "1" "622" "67.8" "8.97" "1.74" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "10629" "ENSG00000162227" "TAF6L" "B2RAT0; hsa:10629; Q96HA6; Q9Y6J9" "HATs acetylate histones" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833474538863443704" "False" "Medium" "IsMasterProtein" "Q9NXZ2" "Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens OX=9606 GN=DDX43 PE=1 SV=2" "0.027" "False" "1.509" "2" "1" "1" "1" "648" "72.8" "8.75" "2.02" "1" "" "" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00270, Pf00271" "55510" "ENSG00000080007" "DDX43" "B4E0C8; hsa:55510; Q6NXR1; Q9NXZ2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991992927110115551" "False" "Medium" "IsMasterProtein" "Q99504" "Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3" "0.027" "False" "1.505" "2" "1" "1" "1" "573" "62.6" "5.21" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00702" "2140" "ENSG00000158161" "EYA3" "A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6608596923630436512" "False" "Medium" "IsMasterProtein" "Q96CD0" "F-box/LRR-repeat protein 8 OS=Homo sapiens OX=9606 GN=FBXL8 PE=1 SV=1" "0.027" "False" "1.504" "3" "1" "1" "1" "374" "40.5" "7.31" "2.08" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937" "55336" "ENSG00000135722" "FBXL8" "hsa:55336; Q96CD0; Q9NUM0" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5976124044734252657" "False" "Medium" "IsMasterProtein" "Q8WYA0" "Intraflagellar transport protein 81 homolog OS=Homo sapiens OX=9606 GN=IFT81 PE=1 SV=1" "0.027" "False" "1.503" "1" "1" "2" "1" "676" "79.7" "8.82" "3.77" "1" "cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf18383" "28981" "ENSG00000122970" "IFT81" "Q2YDY1; Q8NB51; Q8WYA0; Q9BSV2; Q9UNY8" "Intraflagellar transport" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Alstrom syndrome; Bardet-Biedl syndrome" "7" "0" "1.072" "0.834" "1.162" "1.034" "0.786" "1.197" "0.985" "1.094" "0.713" "95.0" "101.8" "79.2" "110.3" "98.2" "74.7" "113.7" "93.5" "104.0" "67.7" "" "" "" "" "" "" "" "" "" "" "85.7" "78.5" "61.2" "74.3" "81.9" "63.7" "96.4" "67.7" "70.1" "67.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6009114136998479207" "False" "Medium" "IsMasterProtein" "Q9GZR1" "Sentrin-specific protease 6 OS=Homo sapiens OX=9606 GN=SENP6 PE=1 SV=2" "0.027" "False" "1.499" "1" "1" "1" "1" "1112" "126.1" "6.73" "1.87" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02902" "26054" "ENSG00000112701" "SENP6" "A6NNY9; hsa:26054; O94891; Q5VUL3; Q5VUL4; Q8TBY4; Q9GZR1; Q9UJV5" "" "" "0" "0" "1.011" "0.696" "0.811" "0.955" "0.781" "0.804" "0.893" "0.814" "1.000" "51.7" "52.3" "36.0" "41.9" "49.3" "40.4" "41.5" "46.2" "42.1" "51.7" "" "" "" "" "" "" "" "" "" "" "46.7" "40.3" "27.8" "28.2" "41.2" "34.5" "35.2" "33.4" "28.4" "51.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563724113440254403" "False" "Medium" "IsMasterProtein" "Q7Z6J4" "FYVE, RhoGEF and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FGD2 PE=1 SV=1" "0.027" "False" "1.497" "1" "1" "1" "1" "655" "74.8" "6.93" "2.08" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "221472" "ENSG00000146192" "FGD2" "hsa:221472; Q5T8I1; Q6P6A8; Q6ZNL5; Q7Z6J4; Q8IZ32; Q8N868; Q9H7M2" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-303142054863253165" "False" "Medium" "IsMasterProtein" "Q67FW5" "Queuosine-tRNA galactosyltransferase OS=Homo sapiens OX=9606 GN=B3GNTL1 PE=1 SV=3" "0.027" "False" "1.496" "2" "1" "1" "1" "346" "39.4" "7.78" "0.00" "1" "" "" "other molecular function" "Pf00535" "146712" "ENSG00000175711; ENSG00000277033" "B3GNTL1" "hsa:146712; Q67FW5; Q6GV30; Q8WUT3" "O-linked glycosylation of mucins" "" "1" "0" "1.020" "0.987" "0.954" "0.820" "0.943" "0.987" "1.066" "1.032" "0.931" "168.0" "171.4" "165.8" "160.4" "137.8" "158.4" "165.8" "179.2" "173.4" "156.5" "" "" "" "" "" "" "" "" "" "" "151.7" "132.2" "128.3" "108.0" "115.0" "135.2" "140.6" "129.7" "116.9" "156.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3705334322242747100" "False" "Medium" "IsMasterProtein" "Q12788" "Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2" "0.027" "False" "1.496" "1" "1" "1" "1" "808" "89.0" "6.90" "2.66" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf08625" "10607" "ENSG00000183751; ENSG00000291938" "TBL3" "hsa:10607; Q12788; Q59GD6; Q8IVB7; Q96A78" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265371385321756616" "False" "Medium" "IsMasterProtein" "P0C671" "Protein BNIP5 OS=Homo sapiens OX=9606 GN=BNIP5 PE=1 SV=1" "0.027" "False" "1.494" "2" "1" "1" "1" "652" "71.9" "8.47" "2.15" "1" "" "" "" "Pf15661" "389384" "ENSG00000189325" "BNIP5" "B2RTY8; P0C671" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7888281618033681663" "False" "Medium" "IsMasterProtein" "Q9H7M9" "V-type immunoglobulin domain-containing suppressor of T-cell activation OS=Homo sapiens OX=9606 GN=VSIR PE=1 SV=3" "0.027" "False" "1.492" "6" "1" "1" "1" "311" "33.9" "6.95" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf07686" "64115" "ENSG00000107738" "VSIR" "A1L0X9; A4ZYV1; A8MVH5; hsa:64115; Q6UXF3; Q8WUG3; Q8WYZ8; Q9H7M9" "" "" "0" "0" "0.901" "0.785" "1.219" "0.844" "1.079" "0.971" "0.880" "0.988" "0.832" "58.0" "52.3" "45.6" "70.8" "49.0" "62.6" "56.3" "51.1" "57.3" "48.3" "" "" "" "" "" "" "" "" "" "" "52.4" "40.3" "35.3" "47.7" "40.9" "53.4" "47.8" "37.0" "38.7" "48.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5652063056633213151" "False" "Medium" "IsMasterProtein" "Q9Y4C4" "Malignant fibrous histiocytoma-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MFHAS1 PE=1 SV=2" "0.028" "False" "1.492" "1" "1" "2" "1" "1052" "116.9" "7.88" "5.07" "1" "stress response;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13855" "9258" "ENSG00000147324" "MFHAS1" "hsa:9258; Q96CI0; Q9Y4C4" "" "8p23.1 copy number variation syndrome" "1" "0" "1.272" "0.877" "1.005" "1.316" "0.868" "1.231" "0.993" "0.883" "2.569" "86.5" "110.1" "75.8" "86.9" "113.8" "75.1" "106.5" "86.0" "76.4" "222.3" "" "" "" "" "" "" "" "" "" "" "78.1" "84.9" "58.7" "58.6" "95.0" "64.1" "90.3" "62.2" "51.5" "222.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1371524125527115551" "False" "Medium" "IsMasterProtein" "Q9NZM3" "Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3" "0.028" "False" "1.491" "0" "1" "1" "1" "1697" "193.3" "8.12" "2.91" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652" "50618" "ENSG00000198399" "ITSN2" "O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4" "Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186316132273188222" "False" "Medium" "IsMasterProtein" "Q92538" "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=3" "0.028" "False" "1.488" "1" "1" "1" "1" "1860" "206.4" "5.73" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf12783" "8729" "ENSG00000107862" "GBF1" "A0A7P0RGV0; hsa:8729; Q149P0; Q149P1; Q5VXX3; Q92538; Q96CK6; Q96HZ3; Q9H473" "VxPx cargo-targeting to cilium; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; trans-Golgi Network Vesicle Budding" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7777121135160287797" "False" "Medium" "IsMasterProtein" "Q9Y2L6" "FERM domain-containing protein 4B OS=Homo sapiens OX=9606 GN=FRMD4B PE=1 SV=4" "0.028" "False" "1.485" "2" "1" "1" "1" "1034" "118.0" "8.62" "0.00" "1" "other biological processes" "cytoskeleton;other cell component" "" "Pf00373, Pf09379, Pf09380, Pf11819" "23150" "ENSG00000114541" "FRMD4B" "hsa:23150; Q8TAI3; Q9Y2L6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630432664316486602" "False" "Medium" "IsMasterProtein" "Q16563" "Synaptophysin-like protein 1 OS=Homo sapiens OX=9606 GN=SYPL1 PE=1 SV=1" "0.028" "False" "1.485" "3" "1" "1" "1" "259" "28.5" "8.43" "2.27" "1" "cell-cell signaling" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf01284" "6856" "ENSG00000008282" "SYPL1" "A4D0R2; hsa:6856; Q16563; Q96AR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "722049298036069008" "False" "Medium" "IsMasterProtein" "Q9BVK6" "Transmembrane emp24 domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TMED9 PE=1 SV=2" "0.028" "False" "1.482" "3" "1" "1" "1" "235" "27.3" "8.02" "2.36" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01105" "54732" "ENSG00000184840" "TMED9" "hsa:54732; Q14437; Q8WZ61; Q9BVK6" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "5q35 copy number variation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8840476301148053294" "False" "Medium" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "0.029" "False" "1.481" "1" "1" "1" "1" "1328" "149.2" "6.74" "1.96" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "TP53 Regulates Transcription of DNA Repair Genes; Fanconi Anemia Pathway" "Gastric cancer network 2; DNA repair pathways, full network; 15q11q13 copy number variation" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786161686779775583" "False" "Medium" "IsMasterProtein" "B4DXR9" "Zinc finger protein 732 OS=Homo sapiens OX=9606 GN=ZNF732 PE=2 SV=1" "0.029" "False" "1.479" "2" "1" "1" "1" "585" "67.8" "8.98" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13912" "654254" "ENSG00000186777" "ZNF732" "B4DXR9; hsa:654254" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3120847238790465854" "False" "Medium" "IsMasterProtein" "Q9NVA4" "Transmembrane protein 184C OS=Homo sapiens OX=9606 GN=TMEM184C PE=1 SV=2" "0.029" "False" "1.476" "2" "1" "1" "1" "438" "50.1" "6.27" "2.43" "1" "" "other membranes" "" "Pf03619" "55751" "ENSG00000164168" "TMEM184C" "D3DP04; hsa:55751; Q86X84; Q969I7; Q9NVA4; Q9NXM2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6995869173039839710" "False" "Medium" "IsMasterProtein" "P19099" "Cytochrome P450 11B2, mitochondrial OS=Homo sapiens OX=9606 GN=CYP11B2 PE=1 SV=3" "0.029" "False" "1.473" "2" "1" "1" "1" "503" "57.5" "9.39" "0.00" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00067" "1585" "ENSG00000179142" "CYP11B2" "B0ZBE4; hsa:1585; P19099; Q16726" "Endogenous sterols; Glucocorticoid biosynthesis; Mineralocorticoid biosynthesis; Defective CYP11B2 causes CMO-1 deficiency" "Oxidation by cytochrome P450; Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism; Nephrotic syndrome; FGF23 signaling in hypophosphatemic rickets and related disorders; Orexin receptor pathway; ACE inhibitor pathway; Metapathway biotransformation Phase I and II" "11" "0" "0.834" "0.839" "1.021" "0.841" "0.758" "0.903" "0.801" "1.035" "0.837" "91.1" "76.0" "76.4" "93.0" "76.6" "69.1" "82.3" "73.0" "94.3" "76.3" "" "" "" "" "" "" "" "" "" "" "82.3" "58.6" "59.1" "62.6" "63.9" "59.0" "69.8" "52.8" "63.6" "76.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "343969761747531800" "False" "Medium" "IsMasterProtein" "Q9C0G0" "Zinc finger protein 407 OS=Homo sapiens OX=9606 GN=ZNF407 PE=1 SV=2" "0.029" "False" "1.472" "0" "1" "1" "1" "2248" "247.2" "6.49" "2.44" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "55628" "ENSG00000215421" "ZNF407" "B5MD54; hsa:55628; Q96MY0; Q9C0G0; Q9H8A1; Q9NXD4; Q9NXD7" "" "" "0" "0" "1.188" "1.199" "1.285" "1.341" "1.126" "1.322" "1.331" "1.141" "3.611" "39.0" "46.3" "46.7" "50.1" "52.3" "43.9" "51.5" "51.8" "44.5" "140.7" "" "" "" "" "" "" "" "" "" "" "35.2" "35.7" "36.1" "33.7" "43.6" "37.5" "43.7" "37.5" "30.0" "140.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2129488681608896086" "False" "Medium" "IsMasterProtein" "Q567V2" "Mpv17-like protein 2 OS=Homo sapiens OX=9606 GN=MPV17L2 PE=1 SV=2" "0.029" "False" "1.471" "10" "1" "2" "1" "206" "23.2" "9.25" "0.00" "1" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "" "Pf04117" "84769" "ENSG00000254858" "MPV17L2" "hsa:84769; Q567V2; Q96P34; Q96QA0; Q9BSG4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "876115928982754265" "False" "Medium" "IsMasterProtein" "P00519" "Tyrosine-protein kinase ABL1 OS=Homo sapiens OX=9606 GN=ABL1 PE=1 SV=4" "0.029" "False" "1.467" "1" "1" "1" "1" "1130" "122.8" "8.66" "2.16" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714, Pf08919" "25" "ENSG00000097007" "ABL1" "A3KFJ3; hsa:25; P00519; Q13869; Q13870; Q16133; Q17R61; Q45F09" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "30" "0" "0.724" "0.829" "0.860" "0.649" "1.118" "0.843" "1.002" "1.191" "1.155" "24.6" "17.8" "20.4" "21.1" "15.9" "27.5" "20.7" "24.6" "29.3" "28.4" "" "" "" "" "" "" "" "" "" "" "22.2" "13.7" "15.8" "14.2" "13.3" "23.4" "17.6" "17.8" "19.7" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2715206749087144500" "False" "Medium" "IsMasterProtein" "Q8WUR7" "UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2" "0.029" "False" "1.466" "5" "1" "2" "1" "153" "16.3" "9.83" "4.88" "1" "" "other cell component" "" "Pf02594" "123207" "ENSG00000169609" "C15orf40" "A6NIC9; B2R5E7; F5GX92; F8WD31; G5EA00; hsa:123207; Q8WUR7" "" "15q25 copy number variation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855468257255932724" "False" "Medium" "IsMasterProtein" "Q96MI6" "Protein phosphatase 1M OS=Homo sapiens OX=9606 GN=PPM1M PE=1 SV=2" "0.030" "False" "1.464" "3" "1" "1" "1" "459" "51.1" "5.82" "2.22" "1" "protein metabolism;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00481" "132160" "ENSG00000164088" "PPM1M" "B7XGB9; F8W976; hsa:132160; Q8N8J9; Q96DB8; Q96MI6" "" "" "0" "0" "1.010" "1.071" "0.930" "0.949" "0.918" "0.912" "1.249" "1.251" "1.048" "14.6" "14.7" "15.6" "13.5" "13.8" "13.4" "13.3" "18.2" "18.2" "15.3" "" "" "" "" "" "" "" "" "" "" "13.2" "11.4" "12.1" "9.1" "11.5" "11.4" "11.3" "13.2" "12.3" "15.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485483695822680049" "False" "Medium" "IsMasterProtein" "Q9Y5R8" "Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1" "0.030" "False" "1.464" "6" "1" "1" "1" "145" "16.8" "9.16" "2.53" "1" "cell organization and biogenesis;transport" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "58485" "ENSG00000170043" "TRAPPC1" "D3DTR0; hsa:58485; Q9Y5R8" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation" "" "3" "0" "1.212" "1.027" "1.269" "1.328" "1.190" "1.081" "1.082" "1.143" "1.829" "30.6" "37.1" "31.5" "38.9" "40.7" "36.5" "33.1" "33.2" "35.0" "56.0" "" "" "" "" "" "" "" "" "" "" "27.7" "28.7" "24.4" "26.2" "34.0" "31.1" "28.1" "24.0" "23.6" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6164740202733872267" "False" "Medium" "IsMasterProtein" "P05107" "Integrin beta-2 OS=Homo sapiens OX=9606 GN=ITGB2 PE=1 SV=3" "0.030" "False" "1.464" "1" "1" "1" "1" "769" "84.7" "6.98" "2.36" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00362, Pf07965, Pf08725, Pf17205" "3689" "ENSG00000160255" "ITGB2" "B3KTS8; D3DSM1; hsa:3689; P05107; Q16418; Q53HS5; Q9UD72" "Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; Toll Like Receptor 4 (TLR4) Cascade; Interleukin-4 and Interleukin-13 signaling" "Integrin-mediated cell adhesion; Complement system; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia; Fibrin complement receptor 3 signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Pleural mesothelioma; Complement system in neuronal development and plasticity; CCL18 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5403362594162546688" "False" "Medium" "IsMasterProtein" "Q15007" "Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2" "0.030" "False" "1.463" "2" "1" "1" "1" "396" "44.2" "5.19" "2.52" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf17098" "9589" "ENSG00000146457" "WTAP" "hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2" "Processing of Capped Intron-Containing Pre-mRNA" "" "1" "0" "1.055" "1.769" "1.000" "1.344" "2.088" "1.175" "1.090" "2.086" "3.342" "40.5" "42.7" "71.6" "40.5" "54.4" "84.6" "47.6" "44.1" "84.5" "135.3" "" "" "" "" "" "" "" "" "" "" "36.6" "33.0" "55.4" "27.3" "45.4" "72.2" "40.4" "31.9" "57.0" "135.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7008941156676408456" "False" "Medium" "IsMasterProtein" "A6NGG8" "Photoreceptor cilium actin regulator OS=Homo sapiens OX=9606 GN=PCARE PE=1 SV=1" "0.030" "False" "1.460" "1" "1" "1" "1" "1288" "139.6" "8.07" "1.86" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf15449" "388939" "ENSG00000179270" "PCARE" "A6NGG8" "" "Ciliopathies; Bardet-Biedl syndrome" "2" "0" "0.798" "1.038" "1.012" "0.890" "0.885" "1.197" "1.345" "1.116" "0.952" "61.1" "48.7" "63.4" "61.8" "54.3" "54.0" "73.1" "82.1" "68.1" "58.1" "" "" "" "" "" "" "" "" "" "" "55.1" "37.6" "49.0" "41.6" "45.3" "46.1" "62.0" "59.4" "45.9" "58.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6437359822954819408" "False" "Medium" "IsMasterProtein" "O75094" "Slit homolog 3 protein OS=Homo sapiens OX=9606 GN=SLIT3 PE=1 SV=3" "0.030" "False" "1.453" "1" "1" "1" "1" "1523" "167.6" "7.65" "2.30" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf00008, Pf01462, Pf01463, Pf02210, Pf12661, Pf13855" "6586" "ENSG00000184347" "SLIT3" "A6H8U9; hsa:6586; J3KNP3; O75094; O95804; Q9UFH5" "Netrin-1 signaling; Regulation of commissural axon pathfinding by SLIT and ROBO" "Spinal cord injury" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5027796018523870386" "False" "Medium" "IsMasterProtein" "Q8WXQ8" "Carboxypeptidase A5 OS=Homo sapiens OX=9606 GN=CPA5 PE=1 SV=1" "0.030" "False" "1.448" "2" "1" "1" "1" "436" "49.0" "6.73" "2.47" "1" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf00246, Pf02244" "93979" "ENSG00000158525" "CPA5" "G3V0G8; hsa:93979; Q6ZNI6; Q86SE2; Q86XM3; Q8NA08; Q8WXQ8" "" "" "0" "0" "0.895" "0.943" "0.710" "0.981" "0.879" "0.970" "0.922" "0.972" "0.751" "167.3" "149.7" "157.7" "118.7" "164.1" "147.0" "162.2" "154.2" "162.6" "125.6" "" "" "" "" "" "" "" "" "" "" "151.0" "115.5" "122.0" "79.9" "136.9" "125.4" "137.6" "111.6" "109.7" "125.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8769161245985835007" "False" "Medium" "IsMasterProtein" "Q9NYF3" "Protein FAM53C OS=Homo sapiens OX=9606 GN=FAM53C PE=1 SV=1" "0.030" "False" "1.447" "2" "1" "1" "1" "392" "43.1" "8.65" "3.13" "1" "transport" "nucleus" "" "Pf15242" "51307" "ENSG00000120709" "FAM53C" "B2RDJ5; D3DQB9; hsa:51307; Q9NYF3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1316883428224227619" "False" "Medium" "IsMasterProtein" "Q8WYQ5" "Microprocessor complex subunit DGCR8 OS=Homo sapiens OX=9606 GN=DGCR8 PE=1 SV=1" "0.030" "False" "1.444" "1" "1" "1" "1" "773" "86.0" "5.95" "2.04" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "54487" "ENSG00000128191" "DGCR8" "B2R8G1; hsa:54487; Q6DCB2; Q6MZE9; Q6Y2L0; Q8WYQ5; Q96G39; Q96GP8; Q9H6L8; Q9H6T7; Q9NRW2" "Transcriptional Regulation by MECP2; MicroRNA (miRNA) biogenesis" "miRNA biogenesis; exRNA mechanism of action and biogenesis; DDX1 as a regulatory component of the Drosha microprocessor; 22q11.2 copy number variation syndrome" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436526655011241506" "False" "Medium" "IsMasterProtein" "P19793" "Retinoic acid receptor RXR-alpha OS=Homo sapiens OX=9606 GN=RXRA PE=1 SV=1" "0.031" "False" "1.438" "2" "1" "1" "1" "462" "50.8" "7.80" "2.56" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf11825" "6256" "ENSG00000186350" "RXRA" "B3KY83; hsa:6256; P19793; Q2NL52; Q2V504" "Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors; Cytoprotection by HMOX1; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis" "Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Th17 cell differentiation pathway; Kleefstra syndrome; Vitamin A1 and A5/X pathways; Vitamin A and carotenoid metabolism" "59" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "246426290930372994" "False" "Medium" "IsMasterProtein" "A8MYB1" "Transmembrane and coiled-coil domain-containing protein 5B OS=Homo sapiens OX=9606 GN=TMCO5B PE=3 SV=1" "0.031" "False" "1.434" "3" "1" "1" "1" "307" "35.7" "5.03" "3.21" "1" "" "other membranes" "" "Pf14992" "" "" "TMCO5B" "A8MYB1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6944601348442643793" "False" "Medium" "IsMasterProtein" "Q460N5" "Protein mono-ADP-ribosyltransferase PARP14 OS=Homo sapiens OX=9606 GN=PARP14 PE=1 SV=3" "0.031" "False" "1.430" "0" "1" "1" "1" "1801" "202.7" "7.18" "2.55" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf01661, Pf02825" "54625" "ENSG00000173193" "PARP14" "B4E2H0; hsa:54625; Q460N4; Q460N5; Q8J027; Q9H9X9; Q9NV60; Q9ULF2" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "" "3" "0" "0.874" "2.334" "1.057" "0.974" "2.050" "0.984" "0.892" "2.038" "7.444" "16.6" "14.5" "38.8" "17.6" "16.2" "34.1" "16.3" "14.8" "33.9" "123.7" "" "" "" "" "" "" "" "" "" "" "15.0" "11.2" "30.0" "11.8" "13.5" "29.1" "13.9" "10.7" "22.8" "123.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-863979425493659150" "False" "Medium" "IsMasterProtein" "Q8TBH0" "Arrestin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ARRDC2 PE=1 SV=2" "0.031" "False" "1.428" "2" "1" "1" "1" "407" "44.4" "9.20" "2.02" "1" "transport" "plasma membrane;other membranes;other cell component" "" "Pf00339, Pf02752" "27106" "ENSG00000105643" "ARRDC2" "B2RBG9; hsa:27106; O95895; Q6ZRV9; Q8TBH0; Q8WYG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2166697322049180134" "False" "Medium" "IsMasterProtein" "Q9UG01" "Intraflagellar transport protein 172 homolog OS=Homo sapiens OX=9606 GN=IFT172 PE=1 SV=2" "0.031" "False" "1.426" "1" "1" "1" "1" "1749" "197.5" "6.13" "2.40" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "26160" "ENSG00000138002" "IFT172" "A5PKZ0; B2RNU5; hsa:26160; Q86X44; Q96HW4; Q9UFJ9; Q9UG01; Q9ULP1" "Intraflagellar transport; Hedgehog 'off' state" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Alstrom syndrome; Bardet-Biedl syndrome" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7634397569492690707" "False" "Medium" "IsMasterProtein" "Q96HY7" "2-oxoadipate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2" "0.031" "False" "1.423" "1" "1" "1" "1" "919" "103.0" "6.93" "2.37" "1" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00676, Pf02779, Pf16870" "55526" "ENSG00000181192" "DHTKD1" "hsa:55526; Q68CU5; Q96HY7; Q9BUM8; Q9HCE2" "Glyoxylate metabolism and glycine degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "742235004239548424" "False" "Medium" "IsMasterProtein" "Q6ICL3" "Transport and Golgi organization protein 2 homolog OS=Homo sapiens OX=9606 GN=TANGO2 PE=1 SV=1" "0.031" "False" "1.422" "3" "1" "1" "1" "276" "30.9" "5.17" "2.61" "1" "cell organization and biogenesis;transport" "cytosol;mitochondrion;ER/Golgi;other cell component" "" "Pf05742" "128989" "ENSG00000183597" "TANGO2" "A8MUE9; B7WNV6; B7Z583; B7Z730; D3DX23; hsa:128989; Q6ICL3; Q8IW05; Q8NAL0; Q8TCS0; Q96M16" "" "22q11.2 copy number variation syndrome" "1" "0" "0.877" "0.916" "0.973" "0.786" "0.912" "0.863" "0.979" "0.917" "0.704" "92.6" "81.1" "84.8" "90.1" "72.7" "84.4" "79.9" "90.6" "84.9" "65.2" "" "" "" "" "" "" "" "" "" "" "83.6" "62.6" "65.6" "60.6" "60.7" "72.1" "67.8" "65.6" "57.3" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2369521365576804156" "False" "Medium" "IsMasterProtein" "Q13488" "V-type proton ATPase 116 kDa subunit a 3 OS=Homo sapiens OX=9606 GN=TCIRG1 PE=1 SV=3" "0.031" "False" "1.422" "1" "1" "1" "1" "830" "92.9" "7.12" "2.12" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf01496" "10312" "ENSG00000110719" "TCIRG1" "hsa:10312; O75877; Q13488; Q8WVC5" "Neutrophil degranulation; ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "TYROBP causal network in microglia; Autosomal recessive osteopetrosis pathways" "8" "0" "1.024" "1.123" "0.970" "0.880" "0.779" "0.975" "1.043" "0.927" "0.686" "48.9" "50.1" "54.9" "47.5" "43.0" "38.1" "47.7" "51.0" "45.4" "33.6" "" "" "" "" "" "" "" "" "" "" "44.2" "38.7" "42.5" "32.0" "35.9" "32.5" "40.5" "36.9" "30.6" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6360176631635833399" "False" "Medium" "IsMasterProtein" "P25054" "Adenomatous polyposis coli protein OS=Homo sapiens OX=9606 GN=APC PE=1 SV=2" "0.032" "False" "1.420" "0" "1" "1" "1" "2843" "311.5" "7.80" "2.31" "1" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00514, Pf05923, Pf05924, Pf05937, Pf05956, Pf05972, Pf11414, Pf16629, Pf16630, Pf16633, Pf16634, Pf16635, Pf16636, Pf16689, Pf18797" "324" "ENSG00000134982" "APC" "B7Z2B6; D3DT03; hsa:324; P25054; Q15162; Q15163; Q93042" "Deactivation of the beta-catenin transactivating complex; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Ovarian tumor domain proteases; Apoptotic cleavage of cellular proteins; APC truncation mutants are not K63 polyubiquitinated" "Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Gastric cancer network 1; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Copper homeostasis; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Regulation of sister chromatid separation at the metaphase-anaphase transition; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Cohesin complex - Cornelia de Lange syndrome; Alzheimer's disease; 2q21.1 copy number variation syndrome; HDAC6 interactions in the central nervous system; DNA damage response (only ATM dependent)" "45" "0" "0.727" "1.530" "0.756" "1.226" "1.233" "0.848" "0.850" "1.207" "0.910" "17.4" "12.7" "26.6" "13.2" "21.4" "21.5" "14.8" "14.8" "21.0" "15.9" "" "" "" "" "" "" "" "" "" "" "15.7" "9.8" "20.6" "8.9" "17.8" "18.3" "12.5" "10.7" "14.2" "15.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1183828596453702303" "False" "Medium" "IsMasterProtein" "Q13402" "Unconventional myosin-VIIa OS=Homo sapiens OX=9606 GN=MYO7A PE=1 SV=2" "0.032" "False" "1.420" "0" "1" "1" "1" "2215" "254.2" "8.57" "2.15" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00373, Pf00612, Pf00784" "4647" "ENSG00000137474" "MYO7A" "B9A011; F8VUN5; hsa:4647; P78427; Q13321; Q13402; Q14785; Q92821; Q92822" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; The canonical retinoid cycle in rods (twilight vision)" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3310116821494939621" "False" "Medium" "IsMasterProtein" "O00584" "Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2" "0.032" "False" "1.418" "3" "1" "1" "1" "256" "29.5" "7.08" "2.50" "1" "RNA metabolism OR transcription;other metabolic processes;stress response" "non-structural extracellular;mitochondrion;ER/Golgi;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00445" "8635" "ENSG00000026297" "RNASET2" "B2RDA7; E1P5C3; hsa:8635; O00584; Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47" "Neutrophil degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2068403974864903156" "False" "Medium" "IsMasterProtein" "Q13530" "Serine incorporator 3 OS=Homo sapiens OX=9606 GN=SERINC3 PE=1 SV=2" "0.032" "False" "1.418" "1" "1" "1" "1" "473" "52.5" "7.46" "2.13" "1" "other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity" "Pf03348" "10955" "ENSG00000132824" "SERINC3" "B4DUE9; hsa:10955; O43717; Q13530; Q9BR33" "Serine biosynthesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957072707787918933" "False" "Medium" "IsMasterProtein" "Q8IW70" "Transmembrane protein 151B OS=Homo sapiens OX=9606 GN=TMEM151B PE=1 SV=2" "0.032" "False" "1.417" "3" "1" "1" "1" "566" "61.5" "7.14" "2.44" "1" "" "other membranes" "" "Pf14857" "441151" "ENSG00000178233" "TMEM151B" "hsa:441151; Q5T9V7; Q8IW70" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7887492268832663165" "False" "Medium" "IsMasterProtein" "Q8N568" "Serine/threonine-protein kinase DCLK2 OS=Homo sapiens OX=9606 GN=DCLK2 PE=1 SV=4" "0.032" "False" "1.414" "2" "1" "1" "1" "766" "83.6" "8.34" "0.00" "1" "cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf03607" "166614" "ENSG00000170390" "DCLK2" "C9J5Q9; hsa:166614; Q59GC8; Q8N399; Q8N568" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345992876989282157" "False" "Medium" "IsMasterProtein" "Q96D03" "DNA damage-inducible transcript 4-like protein OS=Homo sapiens OX=9606 GN=DDIT4L PE=1 SV=1" "0.032" "False" "1.413" "5" "1" "1" "1" "193" "21.7" "7.53" "1.96" "1" "other biological processes" "other cell component" "" "Pf07809" "115265" "ENSG00000145358" "DDIT4L" "B2R7C3; hsa:115265; Q96D03" "" "Target of rapamycin signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-203379576220599078" "False" "Medium" "IsMasterProtein" "Q13158" "FAS-associated death domain protein OS=Homo sapiens OX=9606 GN=FADD PE=1 SV=1" "0.032" "False" "1.412" "3" "1" "1" "1" "208" "23.3" "5.69" "2.81" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf01335" "8772" "ENSG00000168040" "FADD" "hsa:8772; Q13158; Q14866; Q6IBR4" "TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; Regulation of TNFR1 signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway" "33" "0" "0.898" "0.870" "0.952" "1.004" "1.007" "0.850" "0.950" "0.833" "2.571" "46.8" "42.0" "40.7" "44.5" "47.0" "47.1" "39.8" "44.4" "39.0" "120.2" "" "" "" "" "" "" "" "" "" "" "42.2" "32.4" "31.5" "30.0" "39.2" "40.2" "33.7" "32.1" "26.3" "120.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8429437180713985689" "False" "Medium" "IsMasterProtein" "Q13761" "Runt-related transcription factor 3 OS=Homo sapiens OX=9606 GN=RUNX3 PE=1 SV=2" "0.032" "False" "1.411" "2" "1" "1" "1" "415" "44.3" "9.47" "2.91" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "864" "ENSG00000020633" "RUNX3" "B1AJV5; hsa:864; Q12969; Q13760; Q13761" "Regulation of RUNX3 expression and activity; RUNX3 regulates BCL2L11 (BIM) transcription; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; RUNX3 regulates CDKN1A transcription; RUNX3 Regulates Immune Response and Cell Migration; RUNX3 regulates YAP1-mediated transcription; RUNX3 regulates NOTCH signaling; RUNX3 regulates RUNX1-mediated transcription" "TYROBP causal network in microglia; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "16" "0" "0.961" "1.113" "1.263" "0.966" "0.939" "0.987" "1.144" "1.210" "1.828" "57.7" "55.4" "64.2" "72.9" "55.7" "54.2" "56.9" "66.0" "69.8" "105.5" "" "" "" "" "" "" "" "" "" "" "52.1" "42.8" "49.6" "49.1" "46.5" "46.2" "48.3" "47.8" "47.1" "105.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2134905287649132421" "False" "Medium" "IsMasterProtein" "Q9Y312" "Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2" "0.033" "False" "1.398" "2" "1" "1" "1" "384" "43.4" "5.96" "2.31" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf05282, Pf20981" "25980" "ENSG00000131043" "AAR2" "E1P5S7; hsa:25980; Q9H4F9; Q9P1P3; Q9UFK9; Q9Y312" "" "Ciliary landscape" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535284945647851772" "False" "Medium" "IsMasterProtein" "P28068" "HLA class II histocompatibility antigen, DM beta chain OS=Homo sapiens OX=9606 GN=HLA-DMB PE=1 SV=2" "0.033" "False" "1.393" "3" "1" "1" "1" "263" "28.9" "7.44" "2.70" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00969, Pf07654" "3109" "ENSG00000226264; ENSG00000234154; ENSG00000239329; ENSG00000241296; ENSG00000241674; ENSG00000242092; ENSG00000242386; ENSG00000242574" "HLA-DMB" "hsa:3109; O77936; P28068; Q13012; Q29751; Q58ZE2; Q5SNZ8; Q5STC4; Q9XRX2" "MHC class II antigen presentation" "Allograft rejection; Ebola virus infection in host; 11p11.2 copy number variation syndrome" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5891546535660205639" "False" "Medium" "IsMasterProtein" "Q6P1X6" "UPF0598 protein C8orf82 OS=Homo sapiens OX=9606 GN=C8orf82 PE=1 SV=2" "0.033" "False" "1.391" "4" "1" "1" "1" "216" "23.9" "9.14" "1.88" "1" "" "" "" "Pf14956" "414919" "ENSG00000213563" "C8orf82" "hsa:414919; Q6GMR2; Q6P1X6; Q6P2Q7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1059597510691601" "False" "Medium" "IsMasterProtein" "B2RBV5" "MORF4 family associated protein 1 like 2 OS=Homo sapiens OX=9606 GN=MRFAP1L2 PE=1 SV=1" "0.033" "False" "1.385" "10" "1" "1" "1" "119" "13.4" "8.22" "2.76" "1" "other biological processes" "" "" "Pf15155" "" "" "MRFAP1L2" "B2RBV5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8603846715658809849" "False" "Medium" "IsMasterProtein" "Q14807" "Kinesin-like protein KIF22 OS=Homo sapiens OX=9606 GN=KIF22 PE=1 SV=5" "0.034" "False" "1.382" "1" "1" "1" "1" "665" "73.2" "9.45" "1.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225, Pf12836" "3835" "ENSG00000079616" "KIF22" "B2R5M0; B7Z265; hsa:3835; O60845; O94814; Q14807; Q53F58; Q9BT46" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "16p11.2 proximal deletion syndrome" "4" "0" "0.777" "1.098" "0.984" "0.860" "1.169" "0.892" "0.889" "1.334" "1.036" "59.2" "46.0" "65.0" "58.3" "50.9" "69.2" "52.8" "52.6" "79.0" "61.3" "" "" "" "" "" "" "" "" "" "" "53.5" "35.5" "50.3" "39.3" "42.5" "59.1" "44.8" "38.1" "53.3" "61.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8889272797840220039" "False" "Medium" "IsMasterProtein" "Q9UBZ9" "DNA repair protein REV1 OS=Homo sapiens OX=9606 GN=REV1 PE=1 SV=1" "0.034" "False" "1.380" "1" "1" "1" "1" "1251" "138.2" "8.51" "3.09" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00817, Pf11799, Pf14377, Pf16727, Pf21704" "51455" "ENSG00000135945" "REV1" "hsa:51455; O95941; Q53SI7; Q9C0J4; Q9NUP2; Q9UBZ9" "Termination of translesion DNA synthesis; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI" "DNA repair pathways, full network" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "147053636108274367" "False" "Medium" "IsMasterProtein" "Q08AE8" "Protein spire homolog 1 OS=Homo sapiens OX=9606 GN=SPIRE1 PE=1 SV=3" "0.034" "False" "1.378" "1" "1" "1" "1" "756" "85.5" "8.62" "2.52" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity" "Pf16474" "56907" "ENSG00000134278" "SPIRE1" "A8K2B5; hsa:56907; J3KQ50; J3KQR5; Q08AE8; Q1RMD4; Q8NDP1; Q9NQ71; Q9ULT4" "" "VEGFA-VEGFR2 signaling" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "665460954492338555" "False" "Medium" "IsMasterProtein" "Q9NVR7" "TBCC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TBCCD1 PE=1 SV=1" "0.035" "False" "1.371" "1" "1" "1" "1" "557" "63.5" "8.69" "2.13" "1" "other biological processes" "cytoskeleton;other cell component" "" "Pf07986" "55171" "ENSG00000113838" "TBCCD1" "B3KW69; D3DNU6; G5E9J4; hsa:55171; Q9NVR7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8560465734379748063" "False" "Medium" "IsMasterProtein" "Q9NP77" "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1" "0.035" "False" "1.369" "6" "1" "1" "1" "194" "22.6" "5.33" "1.84" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04722" "29101" "ENSG00000160075" "SSU72" "hsa:29101; Q9BZS6; Q9H933; Q9NP77" "RNA polymerase II transcribes snRNA genes" "1p36 copy number variation syndrome" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2315597211980714734" "False" "Medium" "IsMasterProtein" "Q9BRQ8" "Ferroptosis suppressor protein 1 OS=Homo sapiens OX=9606 GN=AIFM2 PE=1 SV=1" "0.035" "False" "1.364" "2" "1" "1" "1" "373" "40.5" "9.11" "2.38" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07992" "84883" "ENSG00000042286" "AIFM2" "B3KXI0; hsa:84883; Q63Z39; Q9BRQ8" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "Apoptosis modulation and signaling; Ferroptosis; Urotensin-II-mediated signaling pathway" "4" "0" "1.108" "1.399" "0.928" "1.143" "1.387" "1.085" "1.251" "1.339" "0.947" "97.2" "107.7" "136.0" "90.2" "111.1" "134.9" "105.5" "121.7" "130.2" "92.1" "" "" "" "" "" "" "" "" "" "" "87.8" "83.1" "105.2" "60.7" "92.7" "115.1" "89.5" "88.1" "87.8" "92.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9221829543246918026" "False" "Medium" "IsMasterProtein" "P23763" "Vesicle-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=VAMP1 PE=1 SV=1" "0.035" "False" "1.363" "6" "1" "1" "1" "118" "12.9" "6.65" "2.53" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6843" "ENSG00000139190" "VAMP1" "A8MVP3; D3DUR3; hsa:6843; O75468; P23763; Q15857; Q6FG94; Q8IVC9" "Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "" "3" "0" "1.001" "0.976" "0.998" "0.911" "0.931" "0.899" "0.949" "1.116" "1.563" "59.3" "59.3" "57.8" "59.2" "54.0" "55.2" "53.3" "56.2" "66.2" "92.6" "" "" "" "" "" "" "" "" "" "" "53.5" "45.8" "44.7" "39.9" "45.0" "47.1" "45.2" "40.7" "44.6" "92.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4408499482478688157" "False" "Medium" "IsMasterProtein" "Q9Y4X4" "Krueppel-like factor 12 OS=Homo sapiens OX=9606 GN=KLF12 PE=1 SV=2" "0.035" "False" "1.362" "3" "1" "1" "1" "402" "44.2" "9.70" "3.23" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "11278" "ENSG00000118922" "KLF12" "A8K5T2; hsa:11278; L0R3J4; Q5VZM7; Q9UHZ0; Q9Y4X4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7393050746196008976" "False" "Medium" "IsMasterProtein" "Q9P2L0" "WD repeat-containing protein 35 OS=Homo sapiens OX=9606 GN=WDR35 PE=1 SV=3" "0.035" "False" "1.362" "1" "1" "1" "1" "1181" "133.5" "6.38" "1.75" "1" "cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "" "Pf00400, Pf12894" "57539" "ENSG00000118965" "WDR35" "B3KVI5; hsa:57539; Q4ZG01; Q8NE11; Q9P2L0" "Intraflagellar transport; Hedgehog 'off' state" "Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "6" "0" "1.372" "1.149" "1.256" "1.165" "1.098" "0.980" "1.053" "1.084" "0.899" "29.1" "40.0" "33.5" "36.6" "33.9" "32.0" "28.6" "30.7" "31.6" "26.2" "" "" "" "" "" "" "" "" "" "" "26.3" "30.8" "25.9" "24.6" "28.3" "27.3" "24.2" "22.2" "21.3" "26.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5441876211868438473" "False" "Medium" "IsMasterProtein" "Q92585" "Mastermind-like protein 1 OS=Homo sapiens OX=9606 GN=MAML1 PE=1 SV=3" "0.035" "False" "1.360" "1" "1" "1" "1" "1016" "108.0" "8.28" "2.31" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09596, Pf20801, Pf20802" "9794" "ENSG00000161021; ENSG00000283780" "MAML1" "hsa:9794; Q92585; Q9NZ12" "NOTCH3 Intracellular Domain Regulates Transcription; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "Notch signaling; Canonical and non-canonical Notch signaling; Head and neck squamous cell carcinoma; Notch signaling pathway" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1555411494366579736" "False" "Medium" "IsMasterProtein" "Q92932" "Receptor-type tyrosine-protein phosphatase N2 OS=Homo sapiens OX=9606 GN=PTPRN2 PE=1 SV=2" "0.036" "False" "1.352" "1" "1" "1" "1" "1015" "111.2" "5.83" "2.51" "1" "cell-cell signaling;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00102, Pf11548, Pf14948" "5799" "ENSG00000155093" "PTPRN2" "E9PC57; hsa:5799; Q8N4I5; Q92662; Q92932; Q9Y4F8; Q9Y4I6" "Neutrophil degranulation" "5q35 copy number variation" "2" "0" "0.991" "0.449" "0.810" "0.744" "0.596" "0.687" "0.773" "0.538" "0.951" "201.1" "199.3" "90.4" "163.0" "149.7" "119.8" "138.2" "155.4" "108.2" "191.3" "" "" "" "" "" "" "" "" "" "" "181.5" "153.7" "69.9" "109.8" "124.9" "102.3" "117.2" "112.5" "73.0" "191.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-265901885640742242" "False" "Medium" "IsMasterProtein" "Q03164" "Histone-lysine N-methyltransferase 2A OS=Homo sapiens OX=9606 GN=KMT2A PE=1 SV=5" "0.036" "False" "1.350" "0" "1" "2" "1" "3969" "431.5" "9.09" "5.36" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771" "4297" "ENSG00000118058" "KMT2A" "E9PQG7; hsa:4297; Q03164; Q13743; Q13744; Q14845; Q16364; Q59FF2; Q6UBD1; Q9HBJ3; Q9UD94; Q9UMA3" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation of granulopoiesis" "Histone modifications" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4003826422992493976" "False" "Medium" "IsMasterProtein" "Q9Y3D0" "Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1" "0.036" "False" "1.346" "4" "1" "1" "1" "163" "17.7" "5.19" "2.33" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01883" "51647" "ENSG00000166595" "CIAO2B" "hsa:51647; Q9Y3D0" "Cytosolic iron-sulfur cluster assembly" "Iron-sulfur cluster biogenesis; 2q11.2 copy number variation syndrome" "3" "0" "0.939" "0.789" "1.113" "0.935" "0.680" "1.019" "0.840" "0.724" "2.923" "73.4" "68.9" "57.9" "81.6" "68.6" "49.9" "74.8" "61.6" "53.1" "214.4" "" "" "" "" "" "" "" "" "" "" "66.2" "53.1" "44.8" "55.0" "57.2" "42.6" "63.4" "44.6" "35.8" "214.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6870653807471889859" "False" "Medium" "IsMasterProtein" "Cont_P00735" "Prothrombin OS=Bos taurus OX=9913 GN=F2 PE=1 SV=2" "0.036" "True" "1.345" "1" "1" "1" "1" "625" "70.5" "6.33" "2.14" "1" "cell organization and biogenesis;protein metabolism;stress response;other biological processes" "non-structural extracellular;extracellular matrix" "other molecular function" "Pf00051, Pf00089, Pf00594, Pf09396" "280685" "" "F2" "bta:280685; P00735; Q3MHK7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-433862157821093001" "False" "Medium" "IsMasterProtein" "P30825" "High affinity cationic amino acid transporter 1 OS=Homo sapiens OX=9606 GN=SLC7A1 PE=1 SV=1" "0.036" "False" "1.343" "2" "1" "1" "1" "629" "67.6" "5.43" "2.44" "1" "transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf13520, Pf13906" "6541" "ENSG00000139514" "SLC7A1" "hsa:6541; P30825; Q5JR50" "Amino acid transport across the plasma membrane" "VEGFA-VEGFR2 signaling" "2" "0" "0.884" "0.883" "1.196" "1.043" "0.692" "1.130" "1.247" "0.937" "0.706" "33.4" "29.6" "29.5" "40.0" "34.9" "23.1" "37.8" "41.7" "31.3" "23.6" "" "" "" "" "" "" "" "" "" "" "30.2" "22.8" "22.8" "26.9" "29.1" "19.8" "32.1" "30.2" "21.1" "23.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6445951316860718443" "False" "Medium" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0.036" "False" "1.342" "1" "1" "1" "1" "1298" "146.5" "7.01" "2.16" "1" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4384787626060275956" "False" "Medium" "IsMasterProtein" "O43286" "Beta-1,4-galactosyltransferase 5 OS=Homo sapiens OX=9606 GN=B4GALT5 PE=1 SV=1" "0.036" "False" "1.342" "5" "1" "1" "1" "388" "45.1" "8.15" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf02709, Pf13733" "9334" "ENSG00000158470" "B4GALT5" "E1P625; hsa:9334; O43286; Q2M394; Q9UJQ8; U6C5D7" "Glycosphingolipid biosynthesis; N-Glycan antennae elongation; Keratan sulfate biosynthesis; O-linked glycosylation of mucins" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002470481848011023" "False" "Medium" "IsMasterProtein" "Q9P032" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Homo sapiens OX=9606 GN=NDUFAF4 PE=1 SV=1" "0.036" "False" "1.342" "4" "1" "1" "1" "175" "20.3" "8.82" "2.91" "1" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf06784" "29078" "ENSG00000123545" "NDUFAF4" "B2R4J5; hsa:29078; Q9P032" "Complex I biogenesis" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1444375086516268996" "False" "Medium" "IsMasterProtein" "Q70Z35" "Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein OS=Homo sapiens OX=9606 GN=PREX2 PE=1 SV=1" "0.036" "False" "1.341" "1" "1" "1" "1" "1606" "182.5" "7.44" "2.01" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00169, Pf00595, Pf00610, Pf00621" "80243" "ENSG00000046889" "PREX2" "B4DFX0; hsa:80243; Q32KL0; Q32KL1; Q6R7Q3; Q6R7Q4; Q70Z35; Q9H805; Q9H961" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; Regulation of PTEN stability and activity" "Melanoma" "5" "0" "1.169" "0.846" "1.107" "1.125" "0.977" "1.147" "1.011" "1.024" "0.618" "41.8" "48.9" "35.4" "46.3" "47.1" "40.8" "48.0" "42.3" "42.8" "25.9" "" "" "" "" "" "" "" "" "" "" "37.8" "37.7" "27.4" "31.2" "39.3" "34.9" "40.7" "30.6" "28.9" "25.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4635662456929640047" "False" "Medium" "IsMasterProtein" "O15304" "Apoptosis regulatory protein Siva OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=2" "0.036" "False" "1.339" "5" "1" "1" "1" "175" "18.7" "7.61" "2.92" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05458" "10572" "ENSG00000184990" "SIVA1" "hsa:10572; O15304; Q96P98; Q9UPD6" "" "p53 transcriptional gene network" "1" "0" "1.045" "0.872" "1.100" "1.077" "1.120" "1.082" "0.948" "1.110" "2.200" "125.2" "130.9" "109.3" "137.8" "134.8" "140.3" "135.5" "118.7" "139.1" "275.5" "" "" "" "" "" "" "" "" "" "" "113.1" "100.9" "84.5" "92.8" "112.5" "119.8" "114.9" "85.9" "93.8" "275.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "361151404237588937" "False" "Medium" "IsMasterProtein" "Q6UXD7" "Solute carrier family 49 member A3 OS=Homo sapiens OX=9606 GN=SLC49A3 PE=1 SV=1" "0.036" "False" "1.338" "2" "1" "1" "1" "560" "58.4" "6.87" "0.00" "1" "transport" "other membranes" "transporter activity" "" "84179" "ENSG00000169026" "SLC49A3" "A8K7J5; hsa:84179; Q6UXD7; Q6XYD4; Q8N6H1; Q9H6H6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8279005894136172160" "False" "Medium" "IsMasterProtein" "Q86WI1" "Fibrocystin-L OS=Homo sapiens OX=9606 GN=PKHD1L1 PE=1 SV=2" "0.036" "False" "1.337" "0" "1" "1" "1" "4243" "465.4" "6.11" "2.40" "1" "other biological processes" "non-structural extracellular;other membranes;cytosol;other cell component" "other molecular function" "Pf01833, Pf07691, Pf10162" "93035" "ENSG00000205038" "PKHD1L1" "hsa:93035; Q567P2; Q86WI1; Q9UF27" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8568977254648879240" "False" "Medium" "IsMasterProtein" "P56715" "Oxygen-regulated protein 1 OS=Homo sapiens OX=9606 GN=RP1 PE=1 SV=1" "0.036" "False" "1.335" "0" "1" "1" "1" "2156" "240.5" "5.80" "2.07" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf03607" "6101" "ENSG00000104237" "RP1" "hsa:6101; P56715" "" "Ciliopathies" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188504720201466914" "False" "Medium" "IsMasterProtein" "P12036" "Neurofilament heavy polypeptide OS=Homo sapiens OX=9606 GN=NEFH PE=1 SV=5" "0.036" "False" "1.333" "1" "1" "1" "1" "1020" "111.8" "6.11" "0.00" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8548442612232049091" "False" "Medium" "IsMasterProtein" "Q9NY46" "Sodium channel protein type 3 subunit alpha OS=Homo sapiens OX=9606 GN=SCN3A PE=1 SV=2" "0.036" "False" "1.332" "1" "1" "1" "1" "2000" "226.1" "5.80" "2.40" "1" "stress response;transport" "plasma membrane;other membranes;cytosol" "transporter activity" "Pf00520, Pf06512, Pf11933" "6328" "ENSG00000153253" "SCN3A" "hsa:6328; Q16142; Q53SX0; Q9BZB3; Q9C006; Q9NY46; Q9NYK2; Q9P2J1; Q9UPD1; Q9Y6P4" "Sensory perception of sweet, bitter, and umami (glutamate) taste; Interaction between L1 and Ankyrins; Phase 0 - rapid depolarisation" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7573088116227200486" "False" "Medium" "IsMasterProtein" "Q13753" "Laminin subunit gamma-2 OS=Homo sapiens OX=9606 GN=LAMC2 PE=1 SV=2" "0.036" "False" "1.330" "1" "1" "1" "1" "1193" "130.9" "6.19" "2.47" "1" "cell adhesion;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "other molecular function" "Pf00052, Pf00053" "3918" "ENSG00000058085" "LAMC2" "hsa:3918; Q02536; Q02537; Q13752; Q13753; Q14941; Q14DF7; Q2M1N2; Q5VYE8" "Degradation of the extracellular matrix; Non-integrin membrane-ECM interactions; Laminin interactions; MET activates PTK2 signaling; Anchoring fibril formation; Type I hemidesmosome assembly" "Alpha 6 beta 4 signaling pathway; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Pleural mesothelioma" "14" "0" "0.900" "1.018" "0.838" "0.924" "0.822" "0.833" "0.960" "1.041" "0.557" "133.9" "120.5" "136.3" "112.2" "123.7" "110.0" "111.6" "128.5" "139.4" "74.6" "" "" "" "" "" "" "" "" "" "" "120.8" "93.0" "105.4" "75.6" "103.2" "93.9" "94.6" "93.0" "94.0" "74.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441085758956725082" "False" "Medium" "IsMasterProtein" "P02778" "C-X-C motif chemokine 10 OS=Homo sapiens OX=9606 GN=CXCL10 PE=1 SV=2" "0.036" "False" "1.330" "12" "1" "1" "1" "98" "10.9" "9.86" "1.70" "1" "cell-cell signaling;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00048" "3627" "ENSG00000169245" "CXCL10" "hsa:3627; P02778; Q96QJ5" "G alpha (i) signalling events; Chemokine receptors bind chemokines; Interleukin-10 signaling" "Spinal cord injury; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Fibrin complement receptor 3 signaling pathway; Hippo-YAP signaling; Hippo-Merlin signaling dysregulation; Interactions between immune cells and microRNAs in tumor microenvironment; Cytosolic DNA-sensing pathway; COVID-19 adverse outcome pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Prostaglandin signaling; Overview of proinflammatory and profibrotic mediators; Lung pathology of COVID-19; Cell interactions of the pancreatic cancer microenvironment; Type II interferon signaling; Toll-like receptor signaling pathway" "20" "0" "1.182" "0.656" "1.127" "0.979" "0.922" "1.030" "0.870" "0.889" "0.916" "21.1" "25.0" "13.8" "23.8" "20.7" "19.5" "21.7" "18.4" "18.8" "19.3" "" "" "" "" "" "" "" "" "" "" "19.1" "19.2" "10.7" "16.0" "17.2" "16.6" "18.4" "13.3" "12.7" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-295339150231154638" "False" "Medium" "IsMasterProtein" "Q6X4U4" "Sclerostin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SOSTDC1 PE=1 SV=2" "0.036" "False" "1.328" "7" "1" "1" "1" "206" "23.3" "9.74" "1.92" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "non-structural extracellular" "kinase activity;other molecular function" "Pf05463" "25928" "ENSG00000171243" "SOSTDC1" "A8MUA6; hsa:25928; Q6X4U4; Q96HJ7; Q9Y3U3" "" "Vitamin D receptor pathway; EDA signaling in hair follicle development" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8675039753664133426" "False" "Medium" "IsMasterProtein" "Q6ZTR7" "CBY1-interacting BAR domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CIBAR2 PE=1 SV=2" "0.036" "False" "1.327" "2" "1" "1" "1" "304" "34.7" "8.66" "2.66" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf06730" "339145" "" "CIBAR2" "A0A0D9SG36; hsa:339145; Q6ZTR7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6499496084090803269" "False" "Medium" "IsMasterProtein" "Q9H329" "Band 4.1-like protein 4B OS=Homo sapiens OX=9606 GN=EPB41L4B PE=1 SV=2" "0.037" "False" "1.325" "1" "1" "1" "1" "900" "99.7" "9.04" "0.00" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00373, Pf08736, Pf09379, Pf09380" "54566" "ENSG00000095203" "EPB41L4B" "hsa:54566; Q5T4G5; Q5T4G6; Q9H328; Q9H329; Q9P2V3" "" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1053300951170364696" "False" "Medium" "IsMasterProtein" "Q9UIG0" "Tyrosine-protein kinase BAZ1B OS=Homo sapiens OX=9606 GN=BAZ1B PE=1 SV=2" "0.038" "False" "1.318" "0" "1" "1" "1" "1483" "170.8" "8.48" "2.64" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf00628, Pf10537, Pf15612, Pf15613" "9031" "ENSG00000009954" "BAZ1B" "B9EGK3; D3DXE9; hsa:9031; O95039; O95247; O95277; Q6P1K4; Q86UJ6; Q9UIG0" "B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4562553461680680521" "False" "Medium" "IsMasterProtein" "Q9Y2Q5" "Ragulator complex protein LAMTOR2 OS=Homo sapiens OX=9606 GN=LAMTOR2 PE=1 SV=1" "0.038" "False" "1.318" "8" "1" "1" "1" "125" "13.5" "5.40" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf03259" "28956" "ENSG00000116586" "LAMTOR2" "hsa:28956; Q5VY97; Q5VY98; Q5VY99; Q9Y2Q5" "Neutrophil degranulation; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; MAP2K and MAPK activation" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6664152256027705153" "False" "Medium" "IsMasterProtein" "Q16560" "U11/U12 small nuclear ribonucleoprotein 35 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP35 PE=1 SV=1" "0.038" "False" "1.315" "3" "1" "1" "1" "246" "29.4" "9.86" "2.29" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076" "11066" "ENSG00000184209" "SNRNP35" "A8K262; hsa:11066; Q16560; Q5XKN9" "mRNA Splicing - Minor Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3648988752962304061" "False" "Medium" "IsMasterProtein" "Q96DY2" "Dynein regulatory complex protein 10 OS=Homo sapiens OX=9606 GN=IQCD PE=1 SV=2" "0.038" "False" "1.315" "2" "1" "2" "1" "449" "52.3" "9.25" "4.66" "1" "" "cytoskeleton;other cell component" "" "Pf00612" "115811" "ENSG00000166578" "IQCD" "hsa:115811; Q6ZSU0; Q96DY2" "" "" "0" "0" "0.974" "1.021" "0.892" "0.781" "0.842" "0.743" "0.869" "1.016" "0.670" "193.4" "188.5" "197.5" "172.5" "151.0" "162.9" "143.6" "168.0" "196.5" "129.6" "" "" "" "" "" "" "" "" "" "" "174.6" "145.4" "152.7" "116.1" "125.9" "139.0" "121.8" "121.6" "132.5" "129.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369173247715702251" "False" "Medium" "IsMasterProtein" "O14763" "Tumor necrosis factor receptor superfamily member 10B OS=Homo sapiens OX=9606 GN=TNFRSF10B PE=1 SV=2" "0.038" "False" "1.313" "3" "1" "1" "1" "440" "47.8" "5.55" "0.00" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00020, Pf00531" "8795" "ENSG00000120889" "TNFRSF10B" "hsa:8795; O14720; O14763; O15508; O15517; O15531; Q6UXM8; Q7Z360; Q9BVE0" "Cell surface interactions at the vascular wall; Regulation by c-FLIP; RIPK1-mediated regulated necrosis; CASP8 activity is inhibited; TP53 Regulates Transcription of Death Receptors and Ligands; Dimerization of procaspase-8; TRAIL signaling" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; miRNA regulation of p53 pathway in prostate cancer; Unfolded protein response; p53 transcriptional gene network; DNA damage response" "16" "0" "0.997" "1.061" "1.364" "1.016" "1.376" "1.373" "1.359" "1.185" "1.386" "10.8" "10.8" "11.5" "14.8" "11.0" "14.9" "14.9" "14.7" "12.9" "15.0" "" "" "" "" "" "" "" "" "" "" "9.8" "8.3" "8.9" "10.0" "9.2" "12.7" "12.6" "10.7" "8.7" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441989282213060776" "False" "Medium" "IsMasterProtein" "Q16552" "Interleukin-17A OS=Homo sapiens OX=9606 GN=IL17A PE=1 SV=1" "0.038" "False" "1.311" "5" "1" "1" "1" "155" "17.5" "8.50" "2.24" "1" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf06083" "3605" "ENSG00000112115" "IL17A" "hsa:3605; Q16552; Q5T2P0" "Interleukin-4 and Interleukin-13 signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interleukin-17 signaling" "IL-17 signaling pathway; Allograft rejection; Development and heterogeneity of the ILC family; Prostaglandin signaling; Overview of proinflammatory and profibrotic mediators; Th17 cell differentiation pathway; Comprehensive IL-17A signaling; COVID-19 and endothelial cell senescence; Neurogenesis regulation in the olfactory epithelium; Immune infiltration in pancreatic cancer; IL-26 signaling pathways; T-cell receptor signaling pathway" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4770714879888361237" "False" "Medium" "IsMasterProtein" "Q5GLZ8" "Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1" "0.038" "False" "1.308" "1" "1" "2" "1" "1057" "118.5" "6.19" "2.18" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632" "26091" "ENSG00000148634" "HERC4" "hsa:26091; Q5GC98; Q5GC99; Q5GCA0; Q5GLZ8; Q8IXP9; Q9HCH9" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5896962611559729209" "False" "Medium" "IsMasterProtein" "O14734" "Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1" "0.039" "False" "1.305" "3" "1" "1" "1" "319" "35.9" "7.56" "2.35" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf02551, Pf13622" "10005" "ENSG00000101473" "ACOT8" "hsa:10005; O14734; O15261; Q17RX4" "Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1034652218568526066" "False" "Medium" "IsMasterProtein" "Q66GS9" "Centrosomal protein of 135 kDa OS=Homo sapiens OX=9606 GN=CEP135 PE=1 SV=2" "0.039" "False" "1.304" "1" "1" "1" "1" "1140" "133.4" "6.21" "1.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "9662" "ENSG00000174799" "CEP135" "B2RMY0; hsa:9662; O75130; Q58F25; Q66GS9; Q9H8H7" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-143757823348630571" "False" "Medium" "IsMasterProtein" "Q8IV08" "5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1" "0.039" "False" "1.302" "2" "1" "1" "1" "490" "54.7" "6.47" "1.80" "1" "DNA metabolism;stress response;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf13918" "23646" "ENSG00000105223" "PLD3" "hsa:23646; Q8IV08; Q92853; Q9BW87" "Role of phospholipids in phagocytosis; Synthesis of PG" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531669477434534246" "False" "Medium" "IsMasterProtein" "Q9NX01" "Thioredoxin-like protein 4B OS=Homo sapiens OX=9606 GN=TXNL4B PE=1 SV=1" "0.039" "False" "1.301" "5" "1" "2" "1" "149" "17.0" "6.00" "3.33" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf02966" "54957" "ENSG00000140830" "TXNL4B" "D3DWS6; hsa:54957; Q9NX01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "284975731923891311" "False" "Medium" "IsMasterProtein" "Q14644" "Ras GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=RASA3 PE=1 SV=3" "0.038" "False" "1.301" "1" "1" "1" "1" "834" "95.6" "7.15" "0.00" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "transporter activity;enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "22821" "ENSG00000185989; ENSG00000280477" "RASA3" "A6NL15; F8W6X8; hsa:22821; Q14644; Q8IUY2" "Regulation of RAS by GAPs" "MAPK cascade; Ras signaling; IL-18 signaling pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5410140500926118897" "False" "Medium" "IsMasterProtein" "Q96PU4" "E3 ubiquitin-protein ligase UHRF2 OS=Homo sapiens OX=9606 GN=UHRF2 PE=1 SV=1" "0.039" "False" "1.297" "1" "1" "1" "1" "802" "89.9" "8.21" "2.44" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "115426" "ENSG00000147854" "UHRF2" "hsa:115426; Q5VYR1; Q5VYR3; Q659C8; Q8TAG7; Q96PU4" "SUMOylation of transcription cofactors" "" "1" "0" "0.853" "0.992" "1.592" "1.057" "1.326" "1.099" "0.506" "1.417" "7.855" "18.3" "15.6" "18.2" "29.2" "19.4" "24.3" "20.2" "9.3" "26.0" "144.1" "" "" "" "" "" "" "" "" "" "" "16.6" "12.1" "14.1" "19.7" "16.2" "20.8" "17.1" "6.7" "17.5" "144.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6133678444779992417" "False" "Medium" "IsMasterProtein" "Q9UGU0" "Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3" "0.039" "False" "1.296" "1" "1" "1" "1" "1960" "211.6" "9.04" "2.58" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13771" "6942" "ENSG00000100207; ENSG00000262024; ENSG00000276461" "TCF20" "A9JX12; hsa:6942; O14528; Q13078; Q4V353; Q9H4M0; Q9UGU0" "" "Matrix metalloproteinases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5016840321552797541" "False" "Medium" "IsMasterProtein" "Q96KP1" "Exocyst complex component 2 OS=Homo sapiens OX=9606 GN=EXOC2 PE=1 SV=1" "0.039" "False" "1.295" "1" "1" "1" "1" "924" "104.0" "6.90" "1.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01833, Pf15469" "55770" "ENSG00000112685" "EXOC2" "B2RBE6; hsa:55770; Q5JPC8; Q96AN6; Q96KP1; Q9NUZ8; Q9UJM7" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Ciliary landscape" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8760607610450426056" "False" "Medium" "IsMasterProtein" "P35251" "Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4" "0.039" "False" "1.295" "1" "1" "1" "1" "1148" "128.2" "9.36" "2.76" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf00533, Pf08519" "5981" "ENSG00000035928" "RFC1" "A8K6E7; hsa:5981; P35251; Q5XKF5; Q6PKU0; Q86V41; Q86V46" "PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "miRNA regulation of DNA damage response; DNA replication; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "22" "0" "1.034" "1.687" "1.037" "1.141" "1.346" "1.171" "1.215" "1.482" "2.275" "47.7" "49.3" "80.4" "49.4" "54.4" "64.2" "55.8" "57.9" "70.7" "108.4" "" "" "" "" "" "" "" "" "" "" "43.0" "38.0" "62.2" "33.3" "45.4" "54.8" "47.4" "41.9" "47.7" "108.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2215661484008569262" "False" "Medium" "IsMasterProtein" "Q9UBW7" "Zinc finger MYM-type protein 2 OS=Homo sapiens OX=9606 GN=ZMYM2 PE=1 SV=1" "0.040" "False" "1.292" "1" "1" "1" "1" "1377" "154.8" "6.34" "2.78" "1" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf06467, Pf12012" "7750" "ENSG00000121741" "ZMYM2" "A6NDG0; A6NI02; hsa:7750; O43212; O43434; O60898; Q5W0Q4; Q5W0T3; Q63HP0; Q8NE39; Q9H0V5; Q9H538; Q9UBW7; Q9UEU2" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5518628090009250384" "False" "Medium" "IsMasterProtein" "Q3V6T2" "Girdin OS=Homo sapiens OX=9606 GN=CCDC88A PE=1 SV=2" "0.040" "False" "1.291" "0" "1" "1" "1" "1871" "215.9" "6.21" "2.28" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "55704" "ENSG00000115355" "CCDC88A" "A1IGE7; B7ZM78; C9JG83; hsa:55704; Q3V6T2; Q53SF1; Q581G3; Q5HYD0; Q7Z339; Q7Z3C5" "RND3 GTPase cycle; RND1 GTPase cycle" "Mesodermal commitment pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1443049690155721947" "False" "Medium" "IsMasterProtein" "Q9H0E2" "Toll-interacting protein OS=Homo sapiens OX=9606 GN=TOLLIP PE=1 SV=1" "0.040" "False" "1.289" "3" "1" "2" "1" "274" "30.3" "5.97" "5.62" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf02845" "54472" "ENSG00000078902; ENSG00000291426" "TOLLIP" "B3KXC6; hsa:54472; Q9H0E2; Q9H9E6; Q9UJ69" "Neutrophil degranulation; Interleukin-1 signaling" "IL-1 signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling related to MyD88; Signal transduction through IL1R; Toll-like receptor signaling pathway" "7" "0" "1.032" "1.111" "1.136" "1.082" "1.039" "1.004" "1.056" "1.092" "1.071" "230.3" "237.6" "255.8" "261.7" "249.1" "239.3" "231.2" "243.1" "251.5" "246.6" "" "" "" "" "" "" "" "" "" "" "207.9" "183.3" "197.8" "176.2" "207.8" "204.3" "196.1" "175.9" "169.6" "246.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2564395705485537843" "False" "Medium" "IsMasterProtein" "Q9UPU9" "Protein Smaug homolog 1 OS=Homo sapiens OX=9606 GN=SAMD4A PE=1 SV=3" "0.040" "False" "1.288" "1" "1" "2" "1" "718" "79.4" "8.32" "5.46" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00536" "23034" "ENSG00000020577" "SAMD4A" "A8MPZ5; hsa:23034; Q0VA96; Q6PEW4; Q9UPU9" "" "" "0" "0" "0.969" "1.145" "1.152" "1.089" "0.996" "1.036" "1.293" "1.496" "0.860" "155.5" "150.7" "178.1" "179.1" "169.4" "154.8" "161.1" "201.1" "232.7" "133.8" "" "" "" "" "" "" "" "" "" "" "140.4" "116.3" "137.8" "120.6" "141.3" "132.2" "136.7" "145.5" "157.0" "133.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4790562829176069588" "False" "Medium" "IsMasterProtein" "Q9BV19" "Uncharacterized protein C1orf50 OS=Homo sapiens OX=9606 GN=C1orf50 PE=1 SV=2" "0.040" "False" "1.287" "4" "1" "1" "1" "199" "21.9" "5.88" "2.41" "1" "" "" "other molecular function" "Pf10504" "79078" "ENSG00000164008" "C1orf50" "Q9BV19" "" "" "0" "0" "1.030" "0.830" "1.075" "0.923" "0.851" "1.038" "1.107" "0.950" "0.829" "94.0" "96.8" "78.0" "101.0" "86.7" "80.0" "97.6" "104.0" "89.2" "77.9" "" "" "" "" "" "" "" "" "" "" "84.8" "74.7" "60.3" "68.0" "72.3" "68.3" "82.8" "75.3" "60.2" "77.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6053253579863259654" "False" "Medium" "IsMasterProtein" "Q9P2M7" "Cingulin OS=Homo sapiens OX=9606 GN=CGN PE=1 SV=3" "0.040" "False" "1.285" "1" "1" "1" "1" "1203" "137.0" "5.52" "2.29" "1" "cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01576" "57530" "ENSG00000143375" "CGN" "A6H8L3; A7MD22; hsa:57530; Q5T386; Q9NR25; Q9P2M7" "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "15q11q13 copy number variation" "2" "0" "1.374" "1.479" "1.476" "1.422" "1.565" "1.112" "1.701" "1.202" "1.040" "12.8" "17.6" "19.0" "18.9" "18.2" "20.1" "14.3" "21.8" "15.4" "13.3" "" "" "" "" "" "" "" "" "" "" "11.6" "13.6" "14.7" "12.8" "15.2" "17.1" "12.1" "15.8" "10.4" "13.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1451874129385953768" "False" "Medium" "IsMasterProtein" "Q9NRD9" "Dual oxidase 1 OS=Homo sapiens OX=9606 GN=DUOX1 PE=1 SV=1" "0.040" "False" "1.284" "1" "1" "2" "1" "1551" "177.1" "7.90" "0.00" "1" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00036, Pf01794, Pf03098, Pf08022, Pf08030, Pf13499" "53905" "ENSG00000137857" "DUOX1" "A6NH28; hsa:53905; Q14C94; Q6ZMB3; Q6ZR09; Q9NRD9; Q9NZC1" "Thyroxine biosynthesis" "Thyroxine (thyroid hormone) production" "2" "0" "1.946" "2.487" "2.037" "2.244" "1.710" "1.983" "1.448" "3.139" "0.759" "12.4" "24.1" "30.8" "25.3" "27.8" "21.2" "24.6" "18.0" "38.9" "9.4" "" "" "" "" "" "" "" "" "" "" "11.2" "18.6" "23.9" "17.0" "23.2" "18.1" "20.9" "13.0" "26.3" "9.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7251525916932761046" "False" "Medium" "IsMasterProtein" "Q9H799" "Ciliogenesis and planar polarity effector 1 OS=Homo sapiens OX=9606 GN=CPLANE1 PE=1 SV=4" "0.041" "False" "1.280" "0" "1" "1" "1" "3197" "361.5" "6.99" "3.17" "1" "cell organization and biogenesis" "other membranes;other cell component" "" "Pf15392" "65250" "ENSG00000197603" "CPLANE1" "A8MUB7; B7ZLV7; hsa:65250; Q4G174; Q6DK46; Q8N8L4; Q9H5T1; Q9H799; Q9H8T9" "" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies" "3" "0" "0.995" "0.996" "1.035" "0.839" "1.003" "0.830" "0.879" "1.168" "0.893" "147.9" "147.1" "147.3" "153.0" "124.0" "148.3" "122.8" "130.0" "172.7" "132.1" "" "" "" "" "" "" "" "" "" "" "133.5" "113.5" "113.9" "103.1" "103.4" "126.6" "104.1" "94.1" "116.5" "132.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8458810131294421202" "False" "Medium" "IsMasterProtein" "Q96IK1" "Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens OX=9606 GN=BOD1 PE=1 SV=2" "0.041" "False" "1.279" "4" "1" "1" "1" "185" "19.2" "6.33" "1.87" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05205" "91272" "ENSG00000145919" "BOD1" "B4DXH8; hsa:91272; Q96IK1; Q9BTW1" "Formation of WDR5-containing histone-modifying complexes" "" "1" "0" "0.821" "0.834" "1.028" "1.087" "0.833" "0.991" "1.034" "0.915" "1.001" "51.2" "42.0" "42.7" "52.7" "55.7" "42.6" "50.7" "52.9" "46.9" "51.2" "" "" "" "" "" "" "" "" "" "" "46.2" "32.4" "33.0" "35.5" "46.5" "36.4" "43.0" "38.3" "31.6" "51.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4599791411515360791" "False" "Medium" "IsMasterProtein" "P39900" "Macrophage metalloelastase OS=Homo sapiens OX=9606 GN=MMP12 PE=1 SV=1" "0.041" "False" "1.277" "1" "1" "1" "1" "470" "54.0" "8.66" "1.97" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00045, Pf00413, Pf01471" "4321" "ENSG00000262406" "MMP12" "B2R9X8; B7ZLF6; hsa:4321; P39900; Q2M1L9" "Collagen degradation" "Matrix metalloproteinases; Spinal cord injury; TGF-beta signaling pathway; Chronic hyperglycemia impairment of neuron function" "6" "0" "1.111" "1.044" "1.017" "0.863" "0.847" "0.975" "0.940" "1.123" "0.602" "56.0" "62.2" "58.4" "56.9" "48.3" "47.4" "54.6" "52.6" "62.8" "33.7" "" "" "" "" "" "" "" "" "" "" "50.5" "48.0" "45.2" "38.3" "40.3" "40.5" "46.3" "38.1" "42.4" "33.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6890831805190457766" "False" "Medium" "IsMasterProtein" "Q9BV73" "Centrosome-associated protein CEP250 OS=Homo sapiens OX=9606 GN=CEP250 PE=1 SV=2" "0.041" "False" "1.277" "0" "1" "1" "1" "2442" "281.0" "5.02" "1.65" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15035" "11190" "ENSG00000126001" "CEP250" "E1P5Q3; hsa:11190; O14812; O60588; Q9BV73; Q9H450" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "Mesodermal commitment pathway" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2164411391658513183" "False" "Medium" "IsMasterProtein" "O94887" "FERM, ARHGEF and pleckstrin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FARP2 PE=1 SV=3" "0.041" "False" "1.275" "1" "1" "1" "1" "1054" "119.8" "8.79" "2.52" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf00169, Pf00373, Pf00621, Pf08736, Pf09379, Pf09380" "9855" "ENSG00000006607" "FARP2" "B7Z6J8; F5GZ84; hsa:9855; O94887; Q53QM5; Q8WU27; Q9UFE7" "RAC1 GTPase cycle; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" "2q37 copy number variation syndrome; TAR syndrome" "4" "0" "0.953" "1.161" "0.927" "0.677" "0.891" "0.970" "0.839" "1.158" "0.837" "101.5" "96.7" "117.8" "94.1" "68.6" "90.4" "98.4" "85.1" "117.5" "84.9" "" "" "" "" "" "" "" "" "" "" "91.6" "74.6" "91.1" "63.4" "57.3" "77.1" "83.5" "61.6" "79.3" "84.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3396571255610308931" "False" "Medium" "IsMasterProtein" "P22692" "Insulin-like growth factor-binding protein 4 OS=Homo sapiens OX=9606 GN=IGFBP4 PE=1 SV=2" "0.042" "False" "1.273" "5" "1" "1" "1" "258" "27.9" "7.15" "0.00" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "non-structural extracellular;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf00219" "3487" "ENSG00000141753" "IGFBP4" "A0N9W2; B4E351; hsa:3487; P22692; Q5U012; Q9UCL6" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "Myometrial relaxation and contraction pathways" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8924414405991965446" "False" "Medium" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "0.042" "False" "1.272" "4" "1" "1" "1" "157" "17.2" "8.91" "2.63" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6292619784892208068" "False" "Medium" "IsMasterProtein" "Q86X19" "Transmembrane protein 17 OS=Homo sapiens OX=9606 GN=TMEM17 PE=1 SV=2" "0.042" "False" "1.269" "4" "1" "1" "1" "198" "23.0" "6.79" "2.41" "1" "cell organization and biogenesis;signal transduction" "plasma membrane;other membranes;other cell component" "" "Pf09799" "200728" "ENSG00000186889" "TMEM17" "hsa:200728; Q53QP7; Q53R98; Q86X19" "" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies" "3" "0" "0.903" "1.114" "0.858" "1.058" "1.094" "1.026" "1.009" "1.061" "0.675" "97.9" "88.4" "109.1" "84.0" "103.6" "107.1" "100.4" "98.8" "103.9" "66.1" "" "" "" "" "" "" "" "" "" "" "88.4" "68.2" "84.4" "56.6" "86.4" "91.4" "85.2" "71.5" "70.1" "66.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7425401848780502306" "False" "Medium" "IsMasterProtein" "Q8NDW4" "Zinc finger protein 248 OS=Homo sapiens OX=9606 GN=ZNF248 PE=1 SV=1" "0.042" "False" "1.268" "2" "1" "1" "1" "579" "67.0" "8.25" "3.42" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "57209" "ENSG00000198105" "ZNF248" "hsa:57209; Q8NDV8; Q8NDW4; Q9UMP3" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3563159699507819169" "False" "Medium" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "0.042" "False" "1.267" "2" "1" "1" "1" "429" "48.7" "5.60" "2.21" "1" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Neutrophil degranulation; Glycosphingolipid catabolism" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1875589299266399931" "False" "Medium" "IsMasterProtein" "Q14139" "Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2" "0.042" "False" "1.267" "1" "1" "1" "1" "1066" "122.5" "5.24" "0.00" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "9354" "ENSG00000110344" "UBE4A" "B0YJB6; Q14139; Q2M1H0; Q6P5T4; Q7Z639" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "1.028" "0.969" "1.176" "0.931" "0.859" "0.931" "0.993" "1.029" "0.792" "90.2" "92.7" "87.4" "106.1" "84.0" "77.5" "83.9" "89.6" "92.8" "71.4" "" "" "" "" "" "" "" "" "" "" "81.4" "71.5" "67.6" "71.4" "70.1" "66.1" "71.2" "64.8" "62.6" "71.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7159093635266280091" "False" "Medium" "IsMasterProtein" "O95295" "SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1" "0.042" "False" "1.266" "5" "1" "1" "1" "136" "14.9" "9.31" "2.94" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14712" "23557" "ENSG00000143553" "SNAPIN" "D3DV56; hsa:23557; O95295; Q5SXU8" "Golgi Associated Vesicle Biogenesis" "Alstrom syndrome" "2" "0" "0.988" "0.992" "1.086" "1.213" "0.957" "0.992" "1.001" "0.967" "0.972" "97.0" "95.9" "96.2" "105.4" "117.7" "92.8" "96.2" "97.2" "93.9" "94.3" "" "" "" "" "" "" "" "" "" "" "87.6" "74.0" "74.4" "70.9" "98.2" "79.2" "81.6" "70.3" "63.3" "94.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5217250070523188386" "False" "Medium" "IsMasterProtein" "O75712" "Gap junction beta-3 protein OS=Homo sapiens OX=9606 GN=GJB3 PE=1 SV=1" "0.043" "False" "1.263" "6" "1" "1" "1" "270" "30.8" "8.59" "1.84" "1" "cell-cell signaling;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00029" "2707" "ENSG00000188910" "GJB3" "B2R790; hsa:2707; O75712; Q2TAZ8" "Gap junction assembly" "Calcium regulation in cardiac cells" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7792324858940339683" "False" "Medium" "IsMasterProtein" "Q5THJ4" "Intermembrane lipid transfer protein VPS13D OS=Homo sapiens OX=9606 GN=VPS13D PE=1 SV=2" "0.043" "False" "1.263" "0" "1" "1" "1" "4388" "491.6" "6.58" "0.00" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes" "" "Pf00627, Pf06650, Pf12624, Pf16908, Pf16909, Pf16910" "55187" "ENSG00000048707" "VPS13D" "hsa:55187; J3KP14; Q58F10; Q5THJ4; Q6MZK9; Q6ZV12; Q709C4; Q709C5; Q86UB4; Q9NSJ3; Q9UIM0" "" "" "0" "0" "0.993" "1.232" "0.996" "0.951" "1.070" "0.893" "0.957" "1.088" "0.611" "136.1" "135.2" "167.7" "135.6" "129.5" "145.6" "121.6" "130.3" "148.1" "83.2" "" "" "" "" "" "" "" "" "" "" "122.9" "104.3" "129.7" "91.3" "108.0" "124.3" "103.2" "94.3" "99.9" "83.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990155463246362264" "False" "Medium" "IsMasterProtein" "Q8NHB8" "Olfactory receptor 5K2 OS=Homo sapiens OX=9606 GN=OR5K2 PE=1 SV=3" "0.043" "False" "1.262" "2" "1" "2" "1" "316" "35.7" "8.06" "4.96" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "402135" "ENSG00000231861" "OR5K2" "B2RN70; hsa:402135; Q6IF47; Q8NHB8" "Expression and translocation of olfactory receptors" "" "1" "0" "1.020" "1.183" "1.161" "0.991" "1.272" "0.972" "0.927" "1.264" "0.631" "56.1" "57.2" "66.3" "65.1" "55.5" "71.3" "54.5" "51.9" "70.8" "35.4" "" "" "" "" "" "" "" "" "" "" "50.6" "44.1" "51.3" "43.8" "46.3" "60.9" "46.2" "37.6" "47.8" "35.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8892747589052197154" "False" "Medium" "IsMasterProtein" "Q5W0B1" "ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1" "0.043" "False" "1.260" "1" "1" "1" "1" "726" "81.1" "5.72" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13923" "79596" "ENSG00000152193" "OBI1" "B2RN99; hsa:79596; Q5W0B1; Q8TBY2; Q9H0T2; Q9H8M0" "" "" "0" "0" "1.075" "1.088" "1.052" "1.063" "1.129" "1.076" "0.914" "1.241" "1.291" "95.6" "102.7" "104.0" "100.6" "101.6" "107.9" "102.9" "87.4" "118.6" "123.4" "" "" "" "" "" "" "" "" "" "" "86.3" "79.2" "80.4" "67.7" "84.8" "92.1" "87.3" "63.2" "80.0" "123.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991678768207076864" "False" "Medium" "IsMasterProtein" "Q9UNF1" "Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2" "0.042" "False" "1.259" "1" "1" "1" "1" "606" "64.9" "9.32" "2.27" "1" "transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01454" "10916" "ENSG00000102316" "MAGED2" "A6NMX0; hsa:10916; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; Q9UNF1" "Platelet degranulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6552900680666985273" "False" "Medium" "IsMasterProtein" "Q8WV44" "E3 ubiquitin-protein ligase TRIM41 OS=Homo sapiens OX=9606 GN=TRIM41 PE=1 SV=3" "0.043" "False" "1.257" "1" "1" "1" "1" "630" "71.6" "5.06" "2.08" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "90933" "ENSG00000146063" "TRIM41" "B3KNJ6; D3DWR9; hsa:90933; Q5BKT0; Q7L484; Q8WV44; Q96Q10; Q9BSL8" "Antigen processing: Ubiquitination & Proteasome degradation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "43561169089107894" "False" "Medium" "IsMasterProtein" "Q5VWG9" "Transcription initiation factor TFIID subunit 3 OS=Homo sapiens OX=9606 GN=TAF3 PE=1 SV=1" "0.044" "False" "1.252" "1" "1" "1" "1" "929" "103.5" "9.06" "0.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf00628, Pf07524" "83860" "ENSG00000165632" "TAF3" "hsa:83860; Q05DA0; Q5VWG9; Q6GMS5; Q6P6B5; Q86VY6; Q9BQS9; Q9UFI8" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6956424576653365595" "False" "Medium" "IsMasterProtein" "P0CG43" "Putative protein FAM157C OS=Homo sapiens OX=9606 GN=FAM157C PE=3 SV=1" "0.044" "False" "1.250" "2" "1" "1" "1" "387" "43.4" "11.19" "2.73" "1" "" "" "" "" "" "" "FAM157C" "P0CG43" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9074819377594512916" "False" "Medium" "IsMasterProtein" "Q9BQ67" "Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1" "0.044" "False" "1.248" "2" "1" "1" "1" "446" "49.4" "4.92" "2.80" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "83743" "ENSG00000105447" "GRWD1" "A0MNN5; hsa:83743; Q8TF59; Q9BQ67" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-181287195693513573" "False" "Medium" "IsMasterProtein" "Q96EA4" "Protein Spindly OS=Homo sapiens OX=9606 GN=SPDL1 PE=1 SV=2" "0.044" "False" "1.247" "1" "1" "1" "1" "605" "70.1" "5.47" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "54908" "ENSG00000040275" "SPDL1" "B4E393; C9JS47; hsa:54908; Q8TEC8; Q96EA4; Q9HD44; Q9NX97" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "" "6" "0" "1.114" "1.067" "0.951" "1.089" "0.884" "0.987" "1.071" "0.877" "1.877" "29.5" "32.9" "31.5" "28.0" "32.1" "26.1" "29.1" "31.6" "25.9" "55.4" "" "" "" "" "" "" "" "" "" "" "26.6" "25.4" "24.4" "18.9" "26.8" "22.2" "24.7" "22.9" "17.5" "55.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379099822173720066" "False" "Medium" "IsMasterProtein" "Q6N021" "Methylcytosine dioxygenase TET2 OS=Homo sapiens OX=9606 GN=TET2 PE=1 SV=3" "0.045" "False" "1.246" "0" "1" "1" "1" "2002" "223.7" "7.99" "2.22" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12851" "54790" "ENSG00000168769" "TET2" "B5MDU0; hsa:54790; Q2TB88; Q3LIB8; Q6N021; Q96JX5; Q9HCM6; Q9NXW0" "TET1,2,3 and TDG demethylate DNA; Specification of primordial germ cells" "MECP2 and associated Rett syndrome" "3" "0" "1.174" "0.877" "1.069" "1.189" "1.107" "0.945" "1.127" "1.143" "1.027" "42.1" "49.4" "36.9" "45.0" "50.0" "46.6" "39.7" "47.4" "48.1" "43.2" "" "" "" "" "" "" "" "" "" "" "38.0" "38.1" "28.5" "30.3" "41.7" "39.7" "33.7" "34.3" "32.4" "43.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7058356130293402746" "False" "Medium" "IsMasterProtein" "Q6ZRS2" "Helicase SRCAP OS=Homo sapiens OX=9606 GN=SRCAP PE=1 SV=3" "0.045" "False" "1.246" "0" "1" "1" "1" "3230" "343.3" "5.96" "0.00" "1" "cell organization and biogenesis;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529" "10847" "ENSG00000080603" "SRCAP" "B0JZA6; hsa:10847; O15026; Q6ZRS2; Q7Z744; Q9Y5L9" "" "Pathways affected in adenoid cystic carcinoma" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531116507177860716" "False" "Medium" "IsMasterProtein" "Q06609" "DNA repair protein RAD51 homolog 1 OS=Homo sapiens OX=9606 GN=RAD51 PE=1 SV=1" "0.046" "False" "1.244" "2" "1" "1" "1" "339" "36.9" "5.60" "2.71" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423, Pf14520" "5888" "ENSG00000051180" "RAD51" "B0FXP0; B2R8T6; hsa:5888; Q06609; Q6FHX9; Q6ZNA8; Q9BV60" "Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "miRNA regulation of DNA damage response; Homologous recombination; ATM signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; Breast cancer pathway; Pancreatic adenocarcinoma pathway; DNA repair pathways, full network; Primary ovarian insufficiency; DNA damage response" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2950616405929129655" "False" "Medium" "IsMasterProtein" "P54802" "Alpha-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=NAGLU PE=1 SV=2" "0.046" "False" "1.243" "2" "1" "1" "1" "743" "82.2" "6.65" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf05089, Pf12971, Pf12972" "4669" "ENSG00000108784" "NAGLU" "hsa:4669; P54802" "HS-GAG degradation; MPS IIIB - Sanfilippo syndrome B" "Glycosaminoglycan degradation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366471573816439068" "False" "Medium" "IsMasterProtein" "P52179" "Myomesin-1 OS=Homo sapiens OX=9606 GN=MYOM1 PE=1 SV=2" "0.046" "False" "1.243" "1" "1" "2" "1" "1685" "187.5" "6.93" "4.36" "1" "developmental processes;signal transduction;other biological processes" "cytoskeleton" "other molecular function" "Pf00041, Pf07679" "8736" "ENSG00000101605" "MYOM1" "hsa:8736; P52179; Q14BD6; Q6H969; Q6ZUU0" "" "Striated muscle contraction pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-850089972800723912" "False" "Medium" "IsMasterProtein" "Q8N4T0" "Carboxypeptidase A6 OS=Homo sapiens OX=9606 GN=CPA6 PE=1 SV=2" "0.046" "False" "1.238" "3" "1" "1" "1" "437" "51.0" "9.52" "1.91" "1" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf00246, Pf02244" "57094" "ENSG00000165078" "CPA6" "hsa:57094; Q8N4T0; Q8NEX8; Q8TDE8; Q9NRI9" "" "" "0" "0" "0.777" "0.439" "0.849" "1.116" "0.801" "0.571" "0.733" "1.102" "0.736" "19.1" "14.8" "8.4" "16.2" "21.3" "15.3" "10.9" "14.0" "21.0" "14.0" "" "" "" "" "" "" "" "" "" "" "17.2" "11.4" "6.5" "10.9" "17.8" "13.0" "9.2" "10.1" "14.2" "14.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5823057819559300912" "False" "Medium" "IsMasterProtein" "O15230" "Laminin subunit alpha-5 OS=Homo sapiens OX=9606 GN=LAMA5 PE=1 SV=8" "0.046" "False" "1.238" "0" "1" "1" "1" "3695" "399.5" "7.02" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "signal transduction activity or receptor binding" "Pf00052, Pf00053, Pf00054, Pf00055, Pf02210, Pf06008, Pf06009" "3911" "ENSG00000130702" "LAMA5" "hsa:3911; O15230; Q5U4N9; Q8TDF8; Q8WZA7; Q9H1P1" "Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling" "Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Pleural mesothelioma" "15" "0" "1.041" "1.076" "0.771" "0.884" "1.094" "1.017" "0.935" "1.205" "0.747" "83.0" "86.4" "89.4" "64.1" "73.4" "90.8" "84.4" "77.6" "100.1" "62.0" "" "" "" "" "" "" "" "" "" "" "75.0" "66.7" "69.1" "43.1" "61.2" "77.5" "71.6" "56.2" "67.5" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8642503759764886067" "False" "Medium" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0.046" "False" "1.237" "0" "1" "1" "1" "3114" "357.3" "5.10" "2.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Polo-like kinase mediated events" "Gastric cancer network 1; Ciliopathies" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6107104793922959907" "False" "Medium" "IsMasterProtein" "O94832" "Unconventional myosin-Id OS=Homo sapiens OX=9606 GN=MYO1D PE=1 SV=2" "0.046" "False" "1.235" "1" "1" "1" "1" "1006" "116.1" "9.39" "2.22" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4642" "ENSG00000176658" "MYO1D" "A6H8V3; hsa:4642; O94832; Q8NHP9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-767357545140157834" "False" "Medium" "IsMasterProtein" "P51784" "Ubiquitin carboxyl-terminal hydrolase 11 OS=Homo sapiens OX=9606 GN=USP11 PE=1 SV=3" "0.046" "False" "1.232" "1" "1" "1" "1" "963" "109.7" "5.45" "2.39" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "" "ENSG00000102226" "USP11" "B2RTX1; P51784; Q8IUG6; Q9BWE1" "Ub-specific processing proteases; Association of TriC/CCT with target proteins during biosynthesis" "" "2" "0" "1.044" "0.965" "0.919" "0.860" "0.923" "1.196" "0.557" "1.174" "5.799" "20.6" "21.5" "19.8" "18.9" "17.7" "19.0" "24.6" "11.5" "24.1" "119.2" "" "" "" "" "" "" "" "" "" "" "18.6" "16.6" "15.4" "12.7" "14.7" "16.2" "20.9" "8.3" "16.3" "119.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-90342498941342912" "False" "Medium" "IsMasterProtein" "Q8N8R5" "Mitochondrial protein C2orf69 OS=Homo sapiens OX=9606 GN=C2orf69 PE=1 SV=1" "0.046" "False" "1.231" "4" "1" "1" "1" "385" "43.4" "8.09" "0.00" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf10561" "205327" "ENSG00000178074" "C2orf69" "hsa:205327; Q8N8R5; Q8NE30" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5434950316255047491" "False" "Medium" "IsMasterProtein" "P42224" "Signal transducer and activator of transcription 1-alpha/beta OS=Homo sapiens OX=9606 GN=STAT1 PE=1 SV=2" "0.046" "False" "1.230" "1" "1" "1" "1" "750" "87.3" "6.05" "2.33" "1" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12162, Pf21354" "6772" "ENSG00000115415" "STAT1" "A8K989; B2RCA0; D2KFR8; D3DPI7; hsa:6772; P42224; Q53S88; Q53XW4; Q68D00; Q9UDL5" "Signaling by SCF-KIT; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Interleukin-4 and Interleukin-13 signaling; Regulation of RUNX2 expression and activity; PKR-mediated signaling; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants; Downstream signal transduction; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Growth hormone receptor signaling; Interleukin-6 signaling; Interferon alpha/beta signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH3 Intracellular Domain Regulates Transcription; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-27 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Type III interferon signaling; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Allograft rejection; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Kit receptor signaling pathway; IL6 signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Immune response to tuberculosis; Ebola virus infection in host; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Tryptophan metabolism; Hepatitis B infection; Endochondral ossification; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; IL-2 signaling pathway; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; CCL18 signaling pathway; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; 2q13 copy number variation syndrome; TROP2 regulatory signaling; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Type II interferon signaling; Toll-like receptor signaling pathway" "83" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7042305927855089094" "False" "Medium" "IsMasterProtein" "Q96E09" "PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 OS=Homo sapiens OX=9606 GN=PABIR1 PE=1 SV=1" "0.047" "False" "1.228" "3" "1" "1" "1" "287" "30.5" "6.79" "1.76" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "" "116224" "ENSG00000187866" "PABIR1" "hsa:116224; Q96E09" "" "" "0" "0" "1.078" "1.088" "1.197" "1.202" "0.945" "1.070" "0.945" "1.060" "0.702" "107.9" "116.3" "117.4" "129.2" "129.7" "102.0" "115.5" "102.0" "114.4" "75.7" "" "" "" "" "" "" "" "" "" "" "97.4" "89.7" "90.8" "87.0" "108.2" "87.1" "98.0" "73.8" "77.1" "75.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1063370880291225048" "False" "Medium" "IsMasterProtein" "Q9UNN4" "TFIIA-alpha and beta-like factor OS=Homo sapiens OX=9606 GN=GTF2A1L PE=1 SV=2" "0.047" "False" "1.226" "1" "1" "1" "1" "478" "52.4" "4.73" "2.12" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03153" "11036" "ENSG00000242441" "GTF2A1L" "B4DY14; hsa:11036; Q53FD9; Q5D050; Q9UNN4" "" "" "0" "0" "1.007" "1.041" "1.067" "1.134" "0.955" "1.127" "1.105" "0.969" "0.912" "55.8" "56.2" "58.1" "59.6" "63.3" "53.3" "62.9" "61.7" "54.1" "50.9" "" "" "" "" "" "" "" "" "" "" "50.4" "43.4" "44.9" "40.1" "52.8" "45.5" "53.4" "44.6" "36.5" "50.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2115106899080851361" "False" "Medium" "IsMasterProtein" "Q96SQ5" "Zinc finger protein 587 OS=Homo sapiens OX=9606 GN=ZNF587 PE=1 SV=1" "0.047" "False" "1.220" "2" "1" "1" "1" "575" "65.6" "8.92" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "84914" "ENSG00000198466" "ZNF587" "A0AV72; G3V0H5; hsa:84914; Q6ZMK8; Q96SQ5" "Generic Transcription Pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6396845313695786371" "False" "Medium" "IsMasterProtein" "Q8NDX5" "Polyhomeotic-like protein 3 OS=Homo sapiens OX=9606 GN=PHC3 PE=1 SV=1" "0.047" "False" "1.220" "1" "1" "1" "1" "983" "106.1" "6.62" "2.09" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00536, Pf21319" "80012" "ENSG00000173889" "PHC3" "A2RRP9; hsa:80012; Q5HYF0; Q6NSG2; Q8NDX5; Q8NFT7; Q8NFZ1; Q8TBM2; Q9H971; Q9H9I4" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660069339337031106" "False" "Medium" "IsMasterProtein" "Q5T1R4" "Transcription factor HIVEP3 OS=Homo sapiens OX=9606 GN=HIVEP3 PE=1 SV=1" "0.047" "False" "1.219" "0" "1" "1" "1" "2406" "259.3" "7.81" "2.36" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "59269" "ENSG00000127124" "HIVEP3" "A7YY91; hsa:59269; Q5T1R4; Q5T1R5; Q9BZS0; Q9HCL7" "Regulation of RUNX2 expression and activity" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6556358293916075398" "False" "Medium" "IsMasterProtein" "Q9NSQ0" "Putative ribosomal RNA-processing protein 7 homolog B OS=Homo sapiens OX=9606 GN=RRP7BP PE=5 SV=1" "0.048" "False" "1.217" "7" "1" "1" "1" "103" "12.6" "9.73" "2.84" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf12923" "" "" "RRP7BP" "B3KQ98; Q9NSQ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4575175849949223475" "False" "Medium" "IsMasterProtein" "Q16825" "Tyrosine-protein phosphatase non-receptor type 21 OS=Homo sapiens OX=9606 GN=PTPN21 PE=1 SV=2" "0.048" "False" "1.217" "1" "1" "1" "1" "1174" "133.2" "7.90" "2.11" "1" "protein metabolism;other metabolic processes" "cytoskeleton;other cell component" "other molecular function" "Pf00102, Pf00373, Pf09379, Pf09380" "11099" "ENSG00000070778" "PTPN21" "hsa:11099; Q16825" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8483539108042045348" "False" "Medium" "IsMasterProtein" "Q86Y33" "Cell division cycle protein 20 homolog B OS=Homo sapiens OX=9606 GN=CDC20B PE=1 SV=3" "0.048" "False" "1.216" "2" "1" "1" "1" "519" "57.3" "8.47" "2.09" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf12894" "166979" "ENSG00000164287" "CDC20B" "B7WNV8; B9EGL8; C9J6X8; C9JHE9; C9JKL5; hsa:166979; Q86Y31; Q86Y32; Q86Y33; Q8IUZ8; Q8N1S1; Q8NG56" "" "miRNA regulation of DNA damage response" "1" "0" "0.922" "0.732" "0.954" "0.905" "0.729" "0.897" "0.848" "0.981" "0.678" "103.0" "95.0" "75.4" "98.3" "93.3" "75.1" "92.4" "87.4" "101.1" "69.8" "" "" "" "" "" "" "" "" "" "" "93.0" "73.3" "58.3" "66.2" "77.8" "64.1" "78.4" "63.2" "68.2" "69.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079825360121275387" "False" "Medium" "IsMasterProtein" "Q5SNV9" "Uncharacterized protein C1orf167 OS=Homo sapiens OX=9606 GN=C1orf167 PE=2 SV=3" "0.048" "False" "1.215" "1" "1" "1" "1" "1449" "160.4" "10.89" "2.14" "1" "" "" "" "Pf15736" "" "" "C1orf167" "A0A8I5KXP5; hsa:284498" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839291041843081445" "False" "Medium" "IsMasterProtein" "Q9HBK9" "Arsenite methyltransferase OS=Homo sapiens OX=9606 GN=AS3MT PE=1 SV=3" "0.048" "False" "1.215" "2" "1" "1" "1" "375" "41.7" "6.20" "2.60" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf13847" "57412" "ENSG00000214435" "AS3MT" "A6NP79; hsa:57412; Q0VDK3; Q0VDK4; Q5PZ02; Q9HBK9" "Methylation" "Arsenic metabolism and reactive oxygen species generation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3194956700439507601" "False" "Medium" "IsMasterProtein" "Q9UPT5" "Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3" "0.048" "False" "1.215" "1" "1" "1" "1" "735" "83.3" "6.79" "2.35" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03081, Pf20669" "23265" "ENSG00000182473" "EXOC7" "B5MC69; B8XXP2; hsa:23265; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32; Q9UPT5" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "Angiopoietin-like protein 8 regulatory pathway; Ciliary landscape" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8739321920006267002" "False" "Medium" "IsMasterProtein" "Cont_P81187" "Complement factor B OS=Bos taurus OX=9913 GN=CFB PE=1 SV=2" "0.048" "True" "1.214" "1" "1" "1" "1" "761" "85.3" "7.68" "0.00" "1" "protein metabolism;stress response;other biological processes" "non-structural extracellular" "other molecular function" "Pf00084, Pf00089, Pf00092" "109576933; 514076" "ENSBTAG00000046158" "CFB" "A0A6P5DRW8; biu:109576933; bta:514076; P81187; Q2KIU6" "Regulation of Complement cascade; Alternative complement activation; Activation of C3 and C5" "Complement and coagulation cascades" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "121458031031999340" "False" "Medium" "IsMasterProtein" "P35232" "Prohibitin 1 OS=Homo sapiens OX=9606 GN=PHB1 PE=1 SV=1" "0.048" "False" "1.211" "3" "1" "1" "1" "272" "29.8" "5.76" "1.72" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "5245" "ENSG00000167085" "PHB1" "B4DY47; hsa:5245; P35232; Q4VBQ0" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Processing of SMDT1" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589374122047907651" "False" "Medium" "IsMasterProtein" "Q8NEH6" "Meiosis-specific nuclear structural protein 1 OS=Homo sapiens OX=9606 GN=MNS1 PE=1 SV=2" "0.049" "False" "1.208" "2" "1" "1" "1" "495" "60.5" "7.12" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf13868" "55329" "ENSG00000138587" "MNS1" "hsa:55329; Q8IYT6; Q8NEH6; Q9NUP4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7001826016762467306" "False" "Medium" "IsMasterProtein" "Q9NYR9" "NF-kappa-B inhibitor-interacting Ras-like protein 2 OS=Homo sapiens OX=9606 GN=NKIRAS2 PE=1 SV=1" "0.049" "False" "1.206" "4" "1" "1" "1" "191" "21.5" "8.05" "2.59" "1" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00071" "28511" "ENSG00000168256" "NKIRAS2" "A6NCZ5; B3KNN0; B4DNM3; hsa:28511; Q6PK52; Q96KC7; Q9NSX1; Q9NYR9" "RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7121476777469684663" "False" "Medium" "IsMasterProtein" "Q14624" "Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens OX=9606 GN=ITIH4 PE=1 SV=4" "0.049" "False" "1.204" "1" "1" "1" "1" "930" "103.3" "6.98" "1.95" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00092, Pf06668, Pf08487" "3700" "ENSG00000055955" "ITIH4" "B7Z545; E9PGN5; hsa:3700; Q14624; Q15135; Q9P190; Q9UQ54" "Platelet degranulation" "Network map of SARS-CoV-2 signaling pathway; HDAC6 interactions in the central nervous system" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4487199997490175914" "False" "Medium" "IsMasterProtein" "P01034" "Cystatin-C OS=Homo sapiens OX=9606 GN=CST3 PE=1 SV=1" "0.049" "False" "1.204" "11" "1" "1" "1" "146" "15.8" "8.75" "2.17" "1" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1471" "ENSG00000101439" "CST3" "B2R5J9; D3DW42; hsa:1471; P01034; Q6FGW9" "Neutrophil degranulation; Amyloid fiber formation; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5421059181973023880" "False" "Medium" "IsMasterProtein" "Q99743" "Neuronal PAS domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NPAS2 PE=1 SV=3" "0.049" "False" "1.202" "2" "1" "1" "1" "824" "91.7" "6.81" "0.00" "1" "stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf14598" "4862" "ENSG00000170485" "NPAS2" "hsa:4862; Q4ZFV9; Q53SQ3; Q86V96; Q99629; Q99743" "PPARA activates gene expression; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression" "Clock-controlled autophagy in bone metabolism" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-6067622255201761803" "False" "Medium" "IsMasterProtein" "O95059" "Ribonuclease P protein subunit p14 OS=Homo sapiens OX=9606 GN=RPP14 PE=1 SV=3" "0.049" "False" "1.201" "6" "1" "1" "1" "124" "13.7" "7.75" "2.27" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "11102" "ENSG00000163684" "RPP14" "O95059; Q53X97" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "" "2" "0" "1.089" "1.297" "0.985" "1.009" "1.054" "1.304" "1.032" "1.157" "0.747" "42.1" "45.9" "54.7" "41.5" "42.5" "44.4" "54.9" "43.5" "48.8" "31.5" "" "" "" "" "" "" "" "" "" "" "38.0" "35.4" "42.3" "27.9" "35.5" "37.9" "46.6" "31.5" "32.9" "31.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3230319014567467969" "False" "Medium" "IsMasterProtein" "Q5XKL5" "BTB/POZ domain-containing protein 8 OS=Homo sapiens OX=9606 GN=BTBD8 PE=1 SV=3" "0.049" "False" "1.200" "0" "1" "1" "1" "1792" "198.9" "6.15" "2.15" "1" "" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "" "Pf00651, Pf15363" "284697" "ENSG00000189195" "BTBD8" "A0A1B0GUL6; A0A1B0GWG1; hsa:284697; O14767; Q5XKL5; Q6V9S5; Q8N3X7; Q9UPP5" "" "" "0" "0" "1.021" "1.049" "0.923" "0.894" "1.140" "0.938" "0.904" "1.203" "0.498" "45.7" "46.7" "47.9" "42.2" "40.9" "52.1" "42.9" "41.3" "55.0" "22.8" "" "" "" "" "" "" "" "" "" "" "41.3" "36.0" "37.1" "28.4" "34.1" "44.5" "36.4" "29.9" "37.1" "22.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3795332475616993312" "False" "Medium" "IsMasterProtein" "P49746" "Thrombospondin-3 OS=Homo sapiens OX=9606 GN=THBS3 PE=1 SV=1" "0.049" "False" "1.200" "2" "1" "1" "1" "956" "104.1" "4.65" "2.19" "1" "cell adhesion;developmental processes" "non-structural extracellular;other cell component" "other molecular function" "Pf02412, Pf05735, Pf07645, Pf11598" "7059" "ENSG00000169231" "THBS3" "B1AVR8; B4DQ20; hsa:7059; P49746; Q8WV34" "Signaling by PDGF" "Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway" "5" "0" "1.146" "1.109" "1.293" "1.101" "0.953" "1.397" "1.028" "0.708" "0.493" "16.0" "18.3" "17.7" "20.7" "17.6" "15.2" "22.3" "16.4" "11.3" "7.9" "" "" "" "" "" "" "" "" "" "" "14.4" "14.1" "13.7" "13.9" "14.7" "13.0" "19.0" "11.9" "7.6" "7.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2874165042467263127" "False" "Medium" "IsMasterProtein" "Q6PJG6" "BRCA1-associated ATM activator 1 OS=Homo sapiens OX=9606 GN=BRAT1 PE=1 SV=2" "0.049" "False" "1.199" "1" "1" "1" "1" "821" "88.1" "5.27" "0.00" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf02985" "221927" "ENSG00000106009" "BRAT1" "A4D200; C9JY24; hsa:221927; Q6PJG6; Q8IW85; Q8IZ43; Q8WVR8; Q96IV9; Q9H7J8; Q9UFA3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8593755170917475749" "False" "Medium" "IsMasterProtein" "P53803" "DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Homo sapiens OX=9606 GN=POLR2K PE=1 SV=1" "0.049" "False" "1.198" "12" "1" "1" "1" "58" "7.0" "9.06" "1.84" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf03604" "5440" "ENSG00000147669" "POLR2K" "hsa:5440; P53803; Q6IBD4" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; Cytosolic sensors of pathogen-associated DNA ; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "57" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" ""